#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P22301	uniprotkb:Q13651	intact:EBI-1031632|ensembl:ENSP00000412237	intact:EBI-1031656|uniprotkb:B0YJ27|uniprotkb:A8K6I0|ensembl:ENSP00000227752	psi-mi:il10_human(display_long)|uniprotkb:IL10(gene name)|psi-mi:IL10(display_short)|uniprotkb:Cytokine synthesis inhibitory factor(gene name synonym)	psi-mi:i10r1_human(display_long)|uniprotkb:IL10RA(gene name)|psi-mi:IL10RA(display_short)|uniprotkb:IL10R(gene name synonym)|uniprotkb:Interleukin-10 receptor subunit 1(gene name synonym)|uniprotkb:CDw210a(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Logsdon et al. (2002)	pubmed:12513909|imex:IM-24852	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-11302227|imex:IM-24852-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000563.1|go:"GO:0042742"(defense response to bacterium)|go:"GO:0042832"(defense response to protozoan)|ensembl:ENSG00000136634(gene)|ensembl:ENST00000423557(transcript)|go:"GO:0001818"(negative regulation of cytokine production)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0002237"(response to molecule of bacterial origin)|go:"GO:0002639"(positive regulation of immunoglobulin production)|go:"GO:0002719"(negative regulation of cytokine production involved in immune response)|go:"GO:0002875"(negative regulation of chronic inflammatory response to antigenic stimulus)|go:"GO:0002904"(positive regulation of B cell apoptotic process)|go:"GO:0005125"(cytokine activity)|go:"GO:0005141"(interleukin-10 receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0007253"(cytoplasmic sequestering of NF-kappaB)|go:"GO:0007568"(aging)|go:"GO:0008083"(growth factor activity)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0014823"(response to activity)|go:"GO:0014854"(response to inactivity)|go:"GO:0030097"(hemopoiesis)|go:"GO:0030183"(B cell differentiation)|go:"GO:0030595"(leukocyte chemotaxis)|go:"GO:0030886"(negative regulation of myeloid dendritic cell activation)|go:"GO:0030889"(negative regulation of B cell proliferation)|go:"GO:0032687"(negative regulation of interferon-alpha production)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032692"(negative regulation of interleukin-1 production)|go:"GO:0032695"(negative regulation of interleukin-12 production)|go:"GO:0032701"(negative regulation of interleukin-18 production)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032717"(negative regulation of interleukin-8 production)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032868"(response to insulin)|go:"GO:0034115"(negative regulation of heterotypic cell-cell adhesion)|go:"GO:0034116"(positive regulation of heterotypic cell-cell adhesion)|go:"GO:0034465"(response to carbon monoxide)|go:"GO:0035729"(cellular response to hepatocyte growth factor stimulus)|go:"GO:0042092"(type 2 immune response)|go:"GO:0042100"(B cell proliferation)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0042493"|go:"GO:0043032"(positive regulation of macrophage activation)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0045019"(negative regulation of nitric oxide biosynthetic process)|go:"GO:0045191"(regulation of isotype switching)|go:"GO:0045347"(negative regulation of MHC class II biosynthetic process)|go:"GO:0045348"(positive regulation of MHC class II biosynthetic process)|go:"GO:0045787"(positive regulation of cell cycle)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045930"(negative regulation of mitotic cell cycle)|go:"GO:0046427"(positive regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0051045"(negative regulation of membrane protein ectodomain proteolysis)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0060302"(negative regulation of cytokine activity)|go:"GO:0060670"(branching involved in labyrinthine layer morphogenesis)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071392"(cellular response to estradiol stimulus)|go:"GO:0071650"("negative regulation of chemokine (C-C motif) ligand 5 production")|go:"GO:0072577"(endothelial cell apoptotic process)|go:"GO:0097421"(liver regeneration)|go:"GO:1900100"(positive regulation of plasma cell differentiation)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1903034"(regulation of response to wounding)|go:"GO:1903208"(negative regulation of hydrogen peroxide-induced neuron death)|go:"GO:1903672"(positive regulation of sprouting angiogenesis)|go:"GO:1904057"(negative regulation of sensory perception of pain)|go:"GO:1904706"(negative regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:2000273"(positive regulation of signaling receptor activity)|interpro:IPR000098(Interleukin-10)|interpro:IPR009079(Four-helical cytokine-like, core)|interpro:IPR020423|interpro:IPR020443|rcsb pdb:1ILK|rcsb pdb:1INR|rcsb pdb:1J7V|rcsb pdb:1LK3|rcsb pdb:1Y6K|rcsb pdb:2H24|rcsb pdb:2ILK|rcsb pdb:6X93|reactome:R-HSA-6783783|reactome:R-HSA-6785807|reactome:R-HSA-8950505|reactome:R-HSA-9662834|reactome:R-HSA-9664323|dip:DIP-3511N	refseq:NP_001549.2|go:"GO:0004920"(interleukin-10 receptor activity)|ensembl:ENSG00000110324(gene)|ensembl:ENST00000227752(transcript)|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019969"(interleukin-10 binding)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0046427"(positive regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0070086"(ubiquitin-dependent endocytosis)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036116|rcsb pdb:1J7V|rcsb pdb:1LQS|rcsb pdb:1Y6K|rcsb pdb:1Y6M|rcsb pdb:1Y6N|rcsb pdb:5IXI|rcsb pdb:6X93|reactome:R-HSA-6783783|dip:DIP-3512N	-	-	-	figure legend:Table. 1, Fig. 5.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:0.7x10^-9(molar)	2015/10/02	2015/10/12	rogid:wsgbqbimYzkkLA5s2YrEyi1BClQ9606	rogid:sMAPIcNDOtzRHrmx79PMcP9jDRA9606	rigid:M8K/sxp5hA9AfPReKGbiDg8xUKo	false	mutation:134-134	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9GZX6	uniprotkb:Q8N6P7	intact:EBI-8040250|intact:MINT-6693924|ensembl:ENSP00000329384|ensembl:ENSP00000442424	intact:EBI-3940749|uniprotkb:Q9HB22|uniprotkb:A8K839|uniprotkb:B2R9Y9|intact:EBI-28982117|ensembl:ENSP00000270800	psi-mi:il22_human(display_long)|uniprotkb:IL22(gene name)|psi-mi:IL22(display_short)|uniprotkb:ILTIF(gene name synonym)|uniprotkb:UNQ3099/PRO10096(orf name)|uniprotkb:ZCYTO18(gene name synonym)|uniprotkb:IL-10-related T-cell-derived-inducible factor(gene name synonym)|uniprotkb:Cytokine Zcyto18(gene name synonym)	psi-mi:i22r1_human(display_long)|uniprotkb:IL22RA1(gene name)|psi-mi:IL22RA1(display_short)|uniprotkb:IL22R(gene name synonym)|uniprotkb:Cytokine receptor class-II member 9(gene name synonym)|uniprotkb:Cytokine receptor family 2 member 9(gene name synonym)|uniprotkb:ZcytoR11(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Logsdon et al. (2002)	pubmed:12513909|imex:IM-24852	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-11302555|imex:IM-24852-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_065386.1|dip:DIP-46035N|ensembl:ENSG00000127318(gene)|ensembl:ENST00000328087(transcript)|ensembl:ENST00000538666(transcript)|go:"GO:0005125"(cytokine activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006953"(acute-phase response)|go:"GO:0006954"(inflammatory response)|go:"GO:0045518"(interleukin-22 receptor binding)|go:"GO:0051384"(response to glucocorticoid)|interpro:IPR009079(Four-helical cytokine-like, core)|interpro:IPR020423|interpro:IPR020453|mint:Q9GZX6|rcsb pdb:1M4R|rcsb pdb:1YKB|rcsb pdb:3DGC|rcsb pdb:3DLQ|rcsb pdb:3G9V|rcsb pdb:3Q1S|reactome:R-HSA-8854691	ensembl:ENSP00000270800|go:"GO:0042015"(interleukin-20 binding)|go:"GO:0050829"(defense response to Gram-negative bacterium)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036116|mint:Q8N6P7|rcsb pdb:3DGC|rcsb pdb:3DLQ|ensembl:ENSG00000142677(gene)|ensembl:ENST00000270800(transcript)|go:"GO:0004896"(cytokine receptor activity)|rcsb pdb:6DF3|reactome:R-HSA-8854691|go:"GO:0004904"(interferon receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019221"(cytokine-mediated signaling pathway)|refseq:NP_067081.2|dip:DIP-42031N	-	function:Cytokine that contributes to the inflammatory response in vivo|comment:mint	-	figure legend:Fig. 6 C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2015/10/02	2015/10/12	rogid:yeLvTpHRMJWT0niv9ttASw0PkZU9606	rogid:mM7lurDGnIyLP+XnqXH5UcuqEuw9606	rigid:hx2W4qi0OQ2XZRWjyu/ZDlGfAnQ	false	-	sufficient binding region:16-228|his tag:c-c	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9GZX6	uniprotkb:Q8N6P7	intact:EBI-8040250|intact:MINT-6693924|ensembl:ENSP00000329384|ensembl:ENSP00000442424	intact:EBI-3940749|uniprotkb:Q9HB22|uniprotkb:A8K839|uniprotkb:B2R9Y9|intact:EBI-28982117|ensembl:ENSP00000270800	psi-mi:il22_human(display_long)|uniprotkb:IL22(gene name)|psi-mi:IL22(display_short)|uniprotkb:ILTIF(gene name synonym)|uniprotkb:UNQ3099/PRO10096(orf name)|uniprotkb:ZCYTO18(gene name synonym)|uniprotkb:IL-10-related T-cell-derived-inducible factor(gene name synonym)|uniprotkb:Cytokine Zcyto18(gene name synonym)	psi-mi:i22r1_human(display_long)|uniprotkb:IL22RA1(gene name)|psi-mi:IL22RA1(display_short)|uniprotkb:IL22R(gene name synonym)|uniprotkb:Cytokine receptor class-II member 9(gene name synonym)|uniprotkb:Cytokine receptor family 2 member 9(gene name synonym)|uniprotkb:ZcytoR11(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Logsdon et al. (2002)	pubmed:12513909|imex:IM-24852	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-11302637|imex:IM-24852-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_065386.1|dip:DIP-46035N|ensembl:ENSG00000127318(gene)|ensembl:ENST00000328087(transcript)|ensembl:ENST00000538666(transcript)|go:"GO:0005125"(cytokine activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006953"(acute-phase response)|go:"GO:0006954"(inflammatory response)|go:"GO:0045518"(interleukin-22 receptor binding)|go:"GO:0051384"(response to glucocorticoid)|interpro:IPR009079(Four-helical cytokine-like, core)|interpro:IPR020423|interpro:IPR020453|mint:Q9GZX6|rcsb pdb:1M4R|rcsb pdb:1YKB|rcsb pdb:3DGC|rcsb pdb:3DLQ|rcsb pdb:3G9V|rcsb pdb:3Q1S|reactome:R-HSA-8854691	ensembl:ENSP00000270800|go:"GO:0042015"(interleukin-20 binding)|go:"GO:0050829"(defense response to Gram-negative bacterium)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036116|mint:Q8N6P7|rcsb pdb:3DGC|rcsb pdb:3DLQ|ensembl:ENSG00000142677(gene)|ensembl:ENST00000270800(transcript)|go:"GO:0004896"(cytokine receptor activity)|rcsb pdb:6DF3|reactome:R-HSA-8854691|go:"GO:0004904"(interferon receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019221"(cytokine-mediated signaling pathway)|refseq:NP_067081.2|dip:DIP-42031N	-	function:Cytokine that contributes to the inflammatory response in vivo|comment:mint	-	figure legend:Fig. 7 C and D|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2015/10/02	2015/10/12	rogid:yeLvTpHRMJWT0niv9ttASw0PkZU9606	rogid:mM7lurDGnIyLP+XnqXH5UcuqEuw9606	rigid:kKKRhUKuHxtrEfI5r4jD8lNbXGM	false	-	his tag:c-c|sufficient binding region:16-228	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9GZX6	uniprotkb:Q08334	intact:EBI-8040250|intact:MINT-6693924|ensembl:ENSP00000329384|ensembl:ENSP00000442424	intact:EBI-11175900|uniprotkb:Q9BUU4|intact:EBI-28985523|ensembl:ENSP00000290200	psi-mi:il22_human(display_long)|uniprotkb:IL22(gene name)|psi-mi:IL22(display_short)|uniprotkb:ILTIF(gene name synonym)|uniprotkb:UNQ3099/PRO10096(orf name)|uniprotkb:ZCYTO18(gene name synonym)|uniprotkb:IL-10-related T-cell-derived-inducible factor(gene name synonym)|uniprotkb:Cytokine Zcyto18(gene name synonym)	psi-mi:i10r2_human(display_long)|uniprotkb:IL10RB(gene name)|psi-mi:IL10RB(display_short)|uniprotkb:CRFB4(gene name synonym)|uniprotkb:D21S58(gene name synonym)|uniprotkb:D21S66(gene name synonym)|uniprotkb:Cytokine receptor class-II member 4(gene name synonym)|uniprotkb:Cytokine receptor family 2 member 4(gene name synonym)|uniprotkb:Interleukin-10 receptor subunit 2(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Logsdon et al. (2002)	pubmed:12513909|imex:IM-24852	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-11302637|imex:IM-24852-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_065386.1|dip:DIP-46035N|ensembl:ENSG00000127318(gene)|ensembl:ENST00000328087(transcript)|ensembl:ENST00000538666(transcript)|go:"GO:0005125"(cytokine activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006953"(acute-phase response)|go:"GO:0006954"(inflammatory response)|go:"GO:0045518"(interleukin-22 receptor binding)|go:"GO:0051384"(response to glucocorticoid)|interpro:IPR009079(Four-helical cytokine-like, core)|interpro:IPR020423|interpro:IPR020453|mint:Q9GZX6|rcsb pdb:1M4R|rcsb pdb:1YKB|rcsb pdb:3DGC|rcsb pdb:3DLQ|rcsb pdb:3G9V|rcsb pdb:3Q1S|reactome:R-HSA-8854691	refseq:NP_000619.3|ensembl:ENSP00000290200|ensembl:ENSG00000243646(gene)|ensembl:ENST00000290200(transcript)|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0004920"(interleukin-10 receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007165"(signal transduction)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0032002"(interleukin-28 receptor complex)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0046427"(positive regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0051607"(defense response to virus)|go:"GO:1901857"(positive regulation of cellular respiration)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015373(Interferon-alpha/beta receptor, fibronectin type III)|interpro:IPR036116|rcsb pdb:3LQM|rcsb pdb:5T5W|rcsb pdb:6X93|reactome:R-HSA-449836|reactome:R-HSA-6783783|reactome:R-HSA-8854691|dip:DIP-6016N	-	function:Cytokine that contributes to the inflammatory response in vivo|comment:mint	-	figure legend:Fig. 7 C and D|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2015/10/02	2015/10/12	rogid:yeLvTpHRMJWT0niv9ttASw0PkZU9606	rogid:wT7f/hpi5gDfMYRRLXrO5VC5Qlg9606	rigid:kKKRhUKuHxtrEfI5r4jD8lNbXGM	false	-	sufficient binding region:20-220|his tag:n-n	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P22301	uniprotkb:Q13651	intact:EBI-1031632|ensembl:ENSP00000412237	intact:EBI-1031656|uniprotkb:B0YJ27|uniprotkb:A8K6I0|ensembl:ENSP00000227752	psi-mi:il10_human(display_long)|uniprotkb:IL10(gene name)|psi-mi:IL10(display_short)|uniprotkb:Cytokine synthesis inhibitory factor(gene name synonym)	psi-mi:i10r1_human(display_long)|uniprotkb:IL10RA(gene name)|psi-mi:IL10RA(display_short)|uniprotkb:IL10R(gene name synonym)|uniprotkb:Interleukin-10 receptor subunit 1(gene name synonym)|uniprotkb:CDw210a(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Logsdon et al. (2002)	pubmed:12513909|imex:IM-24852	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-11302656|imex:IM-24852-6	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000563.1|go:"GO:0042742"(defense response to bacterium)|go:"GO:0042832"(defense response to protozoan)|ensembl:ENSG00000136634(gene)|ensembl:ENST00000423557(transcript)|go:"GO:0001818"(negative regulation of cytokine production)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0002237"(response to molecule of bacterial origin)|go:"GO:0002639"(positive regulation of immunoglobulin production)|go:"GO:0002719"(negative regulation of cytokine production involved in immune response)|go:"GO:0002875"(negative regulation of chronic inflammatory response to antigenic stimulus)|go:"GO:0002904"(positive regulation of B cell apoptotic process)|go:"GO:0005125"(cytokine activity)|go:"GO:0005141"(interleukin-10 receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0007253"(cytoplasmic sequestering of NF-kappaB)|go:"GO:0007568"(aging)|go:"GO:0008083"(growth factor activity)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0014823"(response to activity)|go:"GO:0014854"(response to inactivity)|go:"GO:0030097"(hemopoiesis)|go:"GO:0030183"(B cell differentiation)|go:"GO:0030595"(leukocyte chemotaxis)|go:"GO:0030886"(negative regulation of myeloid dendritic cell activation)|go:"GO:0030889"(negative regulation of B cell proliferation)|go:"GO:0032687"(negative regulation of interferon-alpha production)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032692"(negative regulation of interleukin-1 production)|go:"GO:0032695"(negative regulation of interleukin-12 production)|go:"GO:0032701"(negative regulation of interleukin-18 production)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032717"(negative regulation of interleukin-8 production)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032868"(response to insulin)|go:"GO:0034115"(negative regulation of heterotypic cell-cell adhesion)|go:"GO:0034116"(positive regulation of heterotypic cell-cell adhesion)|go:"GO:0034465"(response to carbon monoxide)|go:"GO:0035729"(cellular response to hepatocyte growth factor stimulus)|go:"GO:0042092"(type 2 immune response)|go:"GO:0042100"(B cell proliferation)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0042493"|go:"GO:0043032"(positive regulation of macrophage activation)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0045019"(negative regulation of nitric oxide biosynthetic process)|go:"GO:0045191"(regulation of isotype switching)|go:"GO:0045347"(negative regulation of MHC class II biosynthetic process)|go:"GO:0045348"(positive regulation of MHC class II biosynthetic process)|go:"GO:0045787"(positive regulation of cell cycle)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045930"(negative regulation of mitotic cell cycle)|go:"GO:0046427"(positive regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0051045"(negative regulation of membrane protein ectodomain proteolysis)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0060302"(negative regulation of cytokine activity)|go:"GO:0060670"(branching involved in labyrinthine layer morphogenesis)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071392"(cellular response to estradiol stimulus)|go:"GO:0071650"("negative regulation of chemokine (C-C motif) ligand 5 production")|go:"GO:0072577"(endothelial cell apoptotic process)|go:"GO:0097421"(liver regeneration)|go:"GO:1900100"(positive regulation of plasma cell differentiation)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1903034"(regulation of response to wounding)|go:"GO:1903208"(negative regulation of hydrogen peroxide-induced neuron death)|go:"GO:1903672"(positive regulation of sprouting angiogenesis)|go:"GO:1904057"(negative regulation of sensory perception of pain)|go:"GO:1904706"(negative regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:2000273"(positive regulation of signaling receptor activity)|interpro:IPR000098(Interleukin-10)|interpro:IPR009079(Four-helical cytokine-like, core)|interpro:IPR020423|interpro:IPR020443|rcsb pdb:1ILK|rcsb pdb:1INR|rcsb pdb:1J7V|rcsb pdb:1LK3|rcsb pdb:1Y6K|rcsb pdb:2H24|rcsb pdb:2ILK|rcsb pdb:6X93|reactome:R-HSA-6783783|reactome:R-HSA-6785807|reactome:R-HSA-8950505|reactome:R-HSA-9662834|reactome:R-HSA-9664323|dip:DIP-3511N	refseq:NP_001549.2|go:"GO:0004920"(interleukin-10 receptor activity)|ensembl:ENSG00000110324(gene)|ensembl:ENST00000227752(transcript)|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019969"(interleukin-10 binding)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0046427"(positive regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0070086"(ubiquitin-dependent endocytosis)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036116|rcsb pdb:1J7V|rcsb pdb:1LQS|rcsb pdb:1Y6K|rcsb pdb:1Y6M|rcsb pdb:1Y6N|rcsb pdb:5IXI|rcsb pdb:6X93|reactome:R-HSA-6783783|dip:DIP-3512N	-	-	-	figure legend:Fig. 7 A and B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2015/10/02	2015/10/12	rogid:wsgbqbimYzkkLA5s2YrEyi1BClQ9606	rogid:sMAPIcNDOtzRHrmx79PMcP9jDRA9606	rigid:uEN4jRDcgTdMpbgnKTQnhEpEb+8	false	mutation:134-135	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P22301	uniprotkb:Q08334	intact:EBI-1031632|ensembl:ENSP00000412237	intact:EBI-11175900|uniprotkb:Q9BUU4|intact:EBI-28985523|ensembl:ENSP00000290200	psi-mi:il10_human(display_long)|uniprotkb:IL10(gene name)|psi-mi:IL10(display_short)|uniprotkb:Cytokine synthesis inhibitory factor(gene name synonym)	psi-mi:i10r2_human(display_long)|uniprotkb:IL10RB(gene name)|psi-mi:IL10RB(display_short)|uniprotkb:CRFB4(gene name synonym)|uniprotkb:D21S58(gene name synonym)|uniprotkb:D21S66(gene name synonym)|uniprotkb:Cytokine receptor class-II member 4(gene name synonym)|uniprotkb:Cytokine receptor family 2 member 4(gene name synonym)|uniprotkb:Interleukin-10 receptor subunit 2(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Logsdon et al. (2002)	pubmed:12513909|imex:IM-24852	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-11302656|imex:IM-24852-6	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000563.1|go:"GO:0042742"(defense response to bacterium)|go:"GO:0042832"(defense response to protozoan)|ensembl:ENSG00000136634(gene)|ensembl:ENST00000423557(transcript)|go:"GO:0001818"(negative regulation of cytokine production)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0002237"(response to molecule of bacterial origin)|go:"GO:0002639"(positive regulation of immunoglobulin production)|go:"GO:0002719"(negative regulation of cytokine production involved in immune response)|go:"GO:0002875"(negative regulation of chronic inflammatory response to antigenic stimulus)|go:"GO:0002904"(positive regulation of B cell apoptotic process)|go:"GO:0005125"(cytokine activity)|go:"GO:0005141"(interleukin-10 receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0007253"(cytoplasmic sequestering of NF-kappaB)|go:"GO:0007568"(aging)|go:"GO:0008083"(growth factor activity)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0014823"(response to activity)|go:"GO:0014854"(response to inactivity)|go:"GO:0030097"(hemopoiesis)|go:"GO:0030183"(B cell differentiation)|go:"GO:0030595"(leukocyte chemotaxis)|go:"GO:0030886"(negative regulation of myeloid dendritic cell activation)|go:"GO:0030889"(negative regulation of B cell proliferation)|go:"GO:0032687"(negative regulation of interferon-alpha production)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032692"(negative regulation of interleukin-1 production)|go:"GO:0032695"(negative regulation of interleukin-12 production)|go:"GO:0032701"(negative regulation of interleukin-18 production)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032717"(negative regulation of interleukin-8 production)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032868"(response to insulin)|go:"GO:0034115"(negative regulation of heterotypic cell-cell adhesion)|go:"GO:0034116"(positive regulation of heterotypic cell-cell adhesion)|go:"GO:0034465"(response to carbon monoxide)|go:"GO:0035729"(cellular response to hepatocyte growth factor stimulus)|go:"GO:0042092"(type 2 immune response)|go:"GO:0042100"(B cell proliferation)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0042493"|go:"GO:0043032"(positive regulation of macrophage activation)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0045019"(negative regulation of nitric oxide biosynthetic process)|go:"GO:0045191"(regulation of isotype switching)|go:"GO:0045347"(negative regulation of MHC class II biosynthetic process)|go:"GO:0045348"(positive regulation of MHC class II biosynthetic process)|go:"GO:0045787"(positive regulation of cell cycle)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045930"(negative regulation of mitotic cell cycle)|go:"GO:0046427"(positive regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0051045"(negative regulation of membrane protein ectodomain proteolysis)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0060302"(negative regulation of cytokine activity)|go:"GO:0060670"(branching involved in labyrinthine layer morphogenesis)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071392"(cellular response to estradiol stimulus)|go:"GO:0071650"("negative regulation of chemokine (C-C motif) ligand 5 production")|go:"GO:0072577"(endothelial cell apoptotic process)|go:"GO:0097421"(liver regeneration)|go:"GO:1900100"(positive regulation of plasma cell differentiation)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1903034"(regulation of response to wounding)|go:"GO:1903208"(negative regulation of hydrogen peroxide-induced neuron death)|go:"GO:1903672"(positive regulation of sprouting angiogenesis)|go:"GO:1904057"(negative regulation of sensory perception of pain)|go:"GO:1904706"(negative regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:2000273"(positive regulation of signaling receptor activity)|interpro:IPR000098(Interleukin-10)|interpro:IPR009079(Four-helical cytokine-like, core)|interpro:IPR020423|interpro:IPR020443|rcsb pdb:1ILK|rcsb pdb:1INR|rcsb pdb:1J7V|rcsb pdb:1LK3|rcsb pdb:1Y6K|rcsb pdb:2H24|rcsb pdb:2ILK|rcsb pdb:6X93|reactome:R-HSA-6783783|reactome:R-HSA-6785807|reactome:R-HSA-8950505|reactome:R-HSA-9662834|reactome:R-HSA-9664323|dip:DIP-3511N	refseq:NP_000619.3|ensembl:ENSP00000290200|ensembl:ENSG00000243646(gene)|ensembl:ENST00000290200(transcript)|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0004920"(interleukin-10 receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007165"(signal transduction)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0032002"(interleukin-28 receptor complex)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0046427"(positive regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0051607"(defense response to virus)|go:"GO:1901857"(positive regulation of cellular respiration)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015373(Interferon-alpha/beta receptor, fibronectin type III)|interpro:IPR036116|rcsb pdb:3LQM|rcsb pdb:5T5W|rcsb pdb:6X93|reactome:R-HSA-449836|reactome:R-HSA-6783783|reactome:R-HSA-8854691|dip:DIP-6016N	-	-	-	figure legend:Fig. 7 A and B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2015/10/02	2015/10/12	rogid:wsgbqbimYzkkLA5s2YrEyi1BClQ9606	rogid:wT7f/hpi5gDfMYRRLXrO5VC5Qlg9606	rigid:uEN4jRDcgTdMpbgnKTQnhEpEb+8	false	mutation:134-135	his tag:n-n|sufficient binding region:20-220	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9GZX6	uniprotkb:Q8N6P7	intact:EBI-8040250|intact:MINT-6693924|ensembl:ENSP00000329384|ensembl:ENSP00000442424	intact:EBI-3940749|uniprotkb:Q9HB22|uniprotkb:A8K839|uniprotkb:B2R9Y9|intact:EBI-28982117|ensembl:ENSP00000270800	psi-mi:il22_human(display_long)|uniprotkb:IL22(gene name)|psi-mi:IL22(display_short)|uniprotkb:ILTIF(gene name synonym)|uniprotkb:UNQ3099/PRO10096(orf name)|uniprotkb:ZCYTO18(gene name synonym)|uniprotkb:IL-10-related T-cell-derived-inducible factor(gene name synonym)|uniprotkb:Cytokine Zcyto18(gene name synonym)	psi-mi:i22r1_human(display_long)|uniprotkb:IL22RA1(gene name)|psi-mi:IL22RA1(display_short)|uniprotkb:IL22R(gene name synonym)|uniprotkb:Cytokine receptor class-II member 9(gene name synonym)|uniprotkb:Cytokine receptor family 2 member 9(gene name synonym)|uniprotkb:ZcytoR11(gene name synonym)	psi-mi:"MI:0071"(molecular sieving)	Logsdon et al. (2002)	pubmed:12513909|imex:IM-24852	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-11302035|imex:IM-24852-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_065386.1|dip:DIP-46035N|ensembl:ENSG00000127318(gene)|ensembl:ENST00000328087(transcript)|ensembl:ENST00000538666(transcript)|go:"GO:0005125"(cytokine activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006953"(acute-phase response)|go:"GO:0006954"(inflammatory response)|go:"GO:0045518"(interleukin-22 receptor binding)|go:"GO:0051384"(response to glucocorticoid)|interpro:IPR009079(Four-helical cytokine-like, core)|interpro:IPR020423|interpro:IPR020453|mint:Q9GZX6|rcsb pdb:1M4R|rcsb pdb:1YKB|rcsb pdb:3DGC|rcsb pdb:3DLQ|rcsb pdb:3G9V|rcsb pdb:3Q1S|reactome:R-HSA-8854691	ensembl:ENSP00000270800|go:"GO:0042015"(interleukin-20 binding)|go:"GO:0050829"(defense response to Gram-negative bacterium)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036116|mint:Q8N6P7|rcsb pdb:3DGC|rcsb pdb:3DLQ|ensembl:ENSG00000142677(gene)|ensembl:ENST00000270800(transcript)|go:"GO:0004896"(cytokine receptor activity)|rcsb pdb:6DF3|reactome:R-HSA-8854691|go:"GO:0004904"(interferon receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019221"(cytokine-mediated signaling pathway)|refseq:NP_067081.2|dip:DIP-42031N	-	function:Cytokine that contributes to the inflammatory response in vivo|comment:mint	-	figure legend:Fig4. B|comment:"Il-22 and IL-22r1 interact at 1:1 molar ratio."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2015/10/02	2015/12/01	rogid:yeLvTpHRMJWT0niv9ttASw0PkZU9606	rogid:mM7lurDGnIyLP+XnqXH5UcuqEuw9606	rigid:hx2W4qi0OQ2XZRWjyu/ZDlGfAnQ	false	-	his tag:c-c|sufficient binding region:16-228	1	1	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q13651	uniprotkb:P22301	intact:EBI-1031656|uniprotkb:B0YJ27|uniprotkb:A8K6I0|ensembl:ENSP00000227752	intact:EBI-1031632|ensembl:ENSP00000412237	psi-mi:i10r1_human(display_long)|uniprotkb:IL10RA(gene name)|psi-mi:IL10RA(display_short)|uniprotkb:IL10R(gene name synonym)|uniprotkb:Interleukin-10 receptor subunit 1(gene name synonym)|uniprotkb:CDw210a(gene name synonym)	psi-mi:il10_human(display_long)|uniprotkb:IL10(gene name)|psi-mi:IL10(display_short)|uniprotkb:Cytokine synthesis inhibitory factor(gene name synonym)	psi-mi:"MI:0071"(molecular sieving)	Logsdon et al. (2002)	pubmed:12513909|imex:IM-24852	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-11302731|imex:IM-24852-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001549.2|go:"GO:0004920"(interleukin-10 receptor activity)|ensembl:ENSG00000110324(gene)|ensembl:ENST00000227752(transcript)|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019969"(interleukin-10 binding)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0046427"(positive regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0070086"(ubiquitin-dependent endocytosis)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036116|rcsb pdb:1J7V|rcsb pdb:1LQS|rcsb pdb:1Y6K|rcsb pdb:1Y6M|rcsb pdb:1Y6N|rcsb pdb:5IXI|rcsb pdb:6X93|reactome:R-HSA-6783783|dip:DIP-3512N	refseq:NP_000563.1|go:"GO:0042742"(defense response to bacterium)|go:"GO:0042832"(defense response to protozoan)|ensembl:ENSG00000136634(gene)|ensembl:ENST00000423557(transcript)|go:"GO:0001818"(negative regulation of cytokine production)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0002237"(response to molecule of bacterial origin)|go:"GO:0002639"(positive regulation of immunoglobulin production)|go:"GO:0002719"(negative regulation of cytokine production involved in immune response)|go:"GO:0002875"(negative regulation of chronic inflammatory response to antigenic stimulus)|go:"GO:0002904"(positive regulation of B cell apoptotic process)|go:"GO:0005125"(cytokine activity)|go:"GO:0005141"(interleukin-10 receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0007253"(cytoplasmic sequestering of NF-kappaB)|go:"GO:0007568"(aging)|go:"GO:0008083"(growth factor activity)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0014823"(response to activity)|go:"GO:0014854"(response to inactivity)|go:"GO:0030097"(hemopoiesis)|go:"GO:0030183"(B cell differentiation)|go:"GO:0030595"(leukocyte chemotaxis)|go:"GO:0030886"(negative regulation of myeloid dendritic cell activation)|go:"GO:0030889"(negative regulation of B cell proliferation)|go:"GO:0032687"(negative regulation of interferon-alpha production)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032692"(negative regulation of interleukin-1 production)|go:"GO:0032695"(negative regulation of interleukin-12 production)|go:"GO:0032701"(negative regulation of interleukin-18 production)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032717"(negative regulation of interleukin-8 production)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032868"(response to insulin)|go:"GO:0034115"(negative regulation of heterotypic cell-cell adhesion)|go:"GO:0034116"(positive regulation of heterotypic cell-cell adhesion)|go:"GO:0034465"(response to carbon monoxide)|go:"GO:0035729"(cellular response to hepatocyte growth factor stimulus)|go:"GO:0042092"(type 2 immune response)|go:"GO:0042100"(B cell proliferation)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0042493"|go:"GO:0043032"(positive regulation of macrophage activation)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0045019"(negative regulation of nitric oxide biosynthetic process)|go:"GO:0045191"(regulation of isotype switching)|go:"GO:0045347"(negative regulation of MHC class II biosynthetic process)|go:"GO:0045348"(positive regulation of MHC class II biosynthetic process)|go:"GO:0045787"(positive regulation of cell cycle)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045930"(negative regulation of mitotic cell cycle)|go:"GO:0046427"(positive regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0051045"(negative regulation of membrane protein ectodomain proteolysis)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0060302"(negative regulation of cytokine activity)|go:"GO:0060670"(branching involved in labyrinthine layer morphogenesis)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071392"(cellular response to estradiol stimulus)|go:"GO:0071650"("negative regulation of chemokine (C-C motif) ligand 5 production")|go:"GO:0072577"(endothelial cell apoptotic process)|go:"GO:0097421"(liver regeneration)|go:"GO:1900100"(positive regulation of plasma cell differentiation)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1903034"(regulation of response to wounding)|go:"GO:1903208"(negative regulation of hydrogen peroxide-induced neuron death)|go:"GO:1903672"(positive regulation of sprouting angiogenesis)|go:"GO:1904057"(negative regulation of sensory perception of pain)|go:"GO:1904706"(negative regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:2000273"(positive regulation of signaling receptor activity)|interpro:IPR000098(Interleukin-10)|interpro:IPR009079(Four-helical cytokine-like, core)|interpro:IPR020423|interpro:IPR020443|rcsb pdb:1ILK|rcsb pdb:1INR|rcsb pdb:1J7V|rcsb pdb:1LK3|rcsb pdb:1Y6K|rcsb pdb:2H24|rcsb pdb:2ILK|rcsb pdb:6X93|reactome:R-HSA-6783783|reactome:R-HSA-6785807|reactome:R-HSA-8950505|reactome:R-HSA-9662834|reactome:R-HSA-9664323|dip:DIP-3511N	-	-	-	figure legend:Fig. 4B, Fig 6B|comment:"A complex was observed at 1:2 molar ratio ( 2  IL-10:4 sIL-10R1)."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2015/10/02	2015/12/01	rogid:sMAPIcNDOtzRHrmx79PMcP9jDRA9606	rogid:wsgbqbimYzkkLA5s2YrEyi1BClQ9606	rigid:M8K/sxp5hA9AfPReKGbiDg8xUKo	false	-	-	4	2	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P22301	uniprotkb:P22301	intact:EBI-1031632|ensembl:ENSP00000412237	intact:EBI-1031632|ensembl:ENSP00000412237	psi-mi:il10_human(display_long)|uniprotkb:IL10(gene name)|psi-mi:IL10(display_short)|uniprotkb:Cytokine synthesis inhibitory factor(gene name synonym)	psi-mi:il10_human(display_long)|uniprotkb:IL10(gene name)|psi-mi:IL10(display_short)|uniprotkb:Cytokine synthesis inhibitory factor(gene name synonym)	psi-mi:"MI:0071"(molecular sieving)	Logsdon et al. (2002)	pubmed:12513909|imex:IM-24852	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-11427809|imex:IM-24852-11	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000563.1|go:"GO:0042742"(defense response to bacterium)|go:"GO:0042832"(defense response to protozoan)|ensembl:ENSG00000136634(gene)|ensembl:ENST00000423557(transcript)|go:"GO:0001818"(negative regulation of cytokine production)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0002237"(response to molecule of bacterial origin)|go:"GO:0002639"(positive regulation of immunoglobulin production)|go:"GO:0002719"(negative regulation of cytokine production involved in immune response)|go:"GO:0002875"(negative regulation of chronic inflammatory response to antigenic stimulus)|go:"GO:0002904"(positive regulation of B cell apoptotic process)|go:"GO:0005125"(cytokine activity)|go:"GO:0005141"(interleukin-10 receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0007253"(cytoplasmic sequestering of NF-kappaB)|go:"GO:0007568"(aging)|go:"GO:0008083"(growth factor activity)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0014823"(response to activity)|go:"GO:0014854"(response to inactivity)|go:"GO:0030097"(hemopoiesis)|go:"GO:0030183"(B cell differentiation)|go:"GO:0030595"(leukocyte chemotaxis)|go:"GO:0030886"(negative regulation of myeloid dendritic cell activation)|go:"GO:0030889"(negative regulation of B cell proliferation)|go:"GO:0032687"(negative regulation of interferon-alpha production)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032692"(negative regulation of interleukin-1 production)|go:"GO:0032695"(negative regulation of interleukin-12 production)|go:"GO:0032701"(negative regulation of interleukin-18 production)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032717"(negative regulation of interleukin-8 production)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032868"(response to insulin)|go:"GO:0034115"(negative regulation of heterotypic cell-cell adhesion)|go:"GO:0034116"(positive regulation of heterotypic cell-cell adhesion)|go:"GO:0034465"(response to carbon monoxide)|go:"GO:0035729"(cellular response to hepatocyte growth factor stimulus)|go:"GO:0042092"(type 2 immune response)|go:"GO:0042100"(B cell proliferation)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0042493"|go:"GO:0043032"(positive regulation of macrophage activation)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0045019"(negative regulation of nitric oxide biosynthetic process)|go:"GO:0045191"(regulation of isotype switching)|go:"GO:0045347"(negative regulation of MHC class II biosynthetic process)|go:"GO:0045348"(positive regulation of MHC class II biosynthetic process)|go:"GO:0045787"(positive regulation of cell cycle)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045930"(negative regulation of mitotic cell cycle)|go:"GO:0046427"(positive regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0051045"(negative regulation of membrane protein ectodomain proteolysis)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0060302"(negative regulation of cytokine activity)|go:"GO:0060670"(branching involved in labyrinthine layer morphogenesis)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071392"(cellular response to estradiol stimulus)|go:"GO:0071650"("negative regulation of chemokine (C-C motif) ligand 5 production")|go:"GO:0072577"(endothelial cell apoptotic process)|go:"GO:0097421"(liver regeneration)|go:"GO:1900100"(positive regulation of plasma cell differentiation)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1903034"(regulation of response to wounding)|go:"GO:1903208"(negative regulation of hydrogen peroxide-induced neuron death)|go:"GO:1903672"(positive regulation of sprouting angiogenesis)|go:"GO:1904057"(negative regulation of sensory perception of pain)|go:"GO:1904706"(negative regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:2000273"(positive regulation of signaling receptor activity)|interpro:IPR000098(Interleukin-10)|interpro:IPR009079(Four-helical cytokine-like, core)|interpro:IPR020423|interpro:IPR020443|rcsb pdb:1ILK|rcsb pdb:1INR|rcsb pdb:1J7V|rcsb pdb:1LK3|rcsb pdb:1Y6K|rcsb pdb:2H24|rcsb pdb:2ILK|rcsb pdb:6X93|reactome:R-HSA-6783783|reactome:R-HSA-6785807|reactome:R-HSA-8950505|reactome:R-HSA-9662834|reactome:R-HSA-9664323|dip:DIP-3511N	refseq:NP_000563.1|go:"GO:0042742"(defense response to bacterium)|go:"GO:0042832"(defense response to protozoan)|ensembl:ENSG00000136634(gene)|ensembl:ENST00000423557(transcript)|go:"GO:0001818"(negative regulation of cytokine production)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0002237"(response to molecule of bacterial origin)|go:"GO:0002639"(positive regulation of immunoglobulin production)|go:"GO:0002719"(negative regulation of cytokine production involved in immune response)|go:"GO:0002875"(negative regulation of chronic inflammatory response to antigenic stimulus)|go:"GO:0002904"(positive regulation of B cell apoptotic process)|go:"GO:0005125"(cytokine activity)|go:"GO:0005141"(interleukin-10 receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0007253"(cytoplasmic sequestering of NF-kappaB)|go:"GO:0007568"(aging)|go:"GO:0008083"(growth factor activity)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0014823"(response to activity)|go:"GO:0014854"(response to inactivity)|go:"GO:0030097"(hemopoiesis)|go:"GO:0030183"(B cell differentiation)|go:"GO:0030595"(leukocyte chemotaxis)|go:"GO:0030886"(negative regulation of myeloid dendritic cell activation)|go:"GO:0030889"(negative regulation of B cell proliferation)|go:"GO:0032687"(negative regulation of interferon-alpha production)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032692"(negative regulation of interleukin-1 production)|go:"GO:0032695"(negative regulation of interleukin-12 production)|go:"GO:0032701"(negative regulation of interleukin-18 production)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032717"(negative regulation of interleukin-8 production)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032868"(response to insulin)|go:"GO:0034115"(negative regulation of heterotypic cell-cell adhesion)|go:"GO:0034116"(positive regulation of heterotypic cell-cell adhesion)|go:"GO:0034465"(response to carbon monoxide)|go:"GO:0035729"(cellular response to hepatocyte growth factor stimulus)|go:"GO:0042092"(type 2 immune response)|go:"GO:0042100"(B cell proliferation)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0042493"|go:"GO:0043032"(positive regulation of macrophage activation)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0045019"(negative regulation of nitric oxide biosynthetic process)|go:"GO:0045191"(regulation of isotype switching)|go:"GO:0045347"(negative regulation of MHC class II biosynthetic process)|go:"GO:0045348"(positive regulation of MHC class II biosynthetic process)|go:"GO:0045787"(positive regulation of cell cycle)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045930"(negative regulation of mitotic cell cycle)|go:"GO:0046427"(positive regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0051045"(negative regulation of membrane protein ectodomain proteolysis)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0060302"(negative regulation of cytokine activity)|go:"GO:0060670"(branching involved in labyrinthine layer morphogenesis)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071392"(cellular response to estradiol stimulus)|go:"GO:0071650"("negative regulation of chemokine (C-C motif) ligand 5 production")|go:"GO:0072577"(endothelial cell apoptotic process)|go:"GO:0097421"(liver regeneration)|go:"GO:1900100"(positive regulation of plasma cell differentiation)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1903034"(regulation of response to wounding)|go:"GO:1903208"(negative regulation of hydrogen peroxide-induced neuron death)|go:"GO:1903672"(positive regulation of sprouting angiogenesis)|go:"GO:1904057"(negative regulation of sensory perception of pain)|go:"GO:1904706"(negative regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:2000273"(positive regulation of signaling receptor activity)|interpro:IPR000098(Interleukin-10)|interpro:IPR009079(Four-helical cytokine-like, core)|interpro:IPR020423|interpro:IPR020443|rcsb pdb:1ILK|rcsb pdb:1INR|rcsb pdb:1J7V|rcsb pdb:1LK3|rcsb pdb:1Y6K|rcsb pdb:2H24|rcsb pdb:2ILK|rcsb pdb:6X93|reactome:R-HSA-6783783|reactome:R-HSA-6785807|reactome:R-HSA-8950505|reactome:R-HSA-9662834|reactome:R-HSA-9664323|dip:DIP-3511N	-	-	-	figure legend:Fig. 2A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2015/10/02	2015/12/01	rogid:wsgbqbimYzkkLA5s2YrEyi1BClQ9606	rogid:wsgbqbimYzkkLA5s2YrEyi1BClQ9606	rigid:8s0+piQbzE+iSd5PDHMpVyD9eCU	false	-	-	2	0	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9GZX6	uniprotkb:Q8N6P7	intact:EBI-8040250|intact:MINT-6693924|ensembl:ENSP00000329384|ensembl:ENSP00000442424	intact:EBI-3940749|uniprotkb:Q9HB22|uniprotkb:A8K839|uniprotkb:B2R9Y9|intact:EBI-28982117|ensembl:ENSP00000270800	psi-mi:il22_human(display_long)|uniprotkb:IL22(gene name)|psi-mi:IL22(display_short)|uniprotkb:ILTIF(gene name synonym)|uniprotkb:UNQ3099/PRO10096(orf name)|uniprotkb:ZCYTO18(gene name synonym)|uniprotkb:IL-10-related T-cell-derived-inducible factor(gene name synonym)|uniprotkb:Cytokine Zcyto18(gene name synonym)	psi-mi:i22r1_human(display_long)|uniprotkb:IL22RA1(gene name)|psi-mi:IL22RA1(display_short)|uniprotkb:IL22R(gene name synonym)|uniprotkb:Cytokine receptor class-II member 9(gene name synonym)|uniprotkb:Cytokine receptor family 2 member 9(gene name synonym)|uniprotkb:ZcytoR11(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Logsdon et al. (2002)	pubmed:12513909|imex:IM-24852	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-11302122|imex:IM-24852-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_065386.1|dip:DIP-46035N|ensembl:ENSG00000127318(gene)|ensembl:ENST00000328087(transcript)|ensembl:ENST00000538666(transcript)|go:"GO:0005125"(cytokine activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006953"(acute-phase response)|go:"GO:0006954"(inflammatory response)|go:"GO:0045518"(interleukin-22 receptor binding)|go:"GO:0051384"(response to glucocorticoid)|interpro:IPR009079(Four-helical cytokine-like, core)|interpro:IPR020423|interpro:IPR020453|mint:Q9GZX6|rcsb pdb:1M4R|rcsb pdb:1YKB|rcsb pdb:3DGC|rcsb pdb:3DLQ|rcsb pdb:3G9V|rcsb pdb:3Q1S|reactome:R-HSA-8854691	ensembl:ENSP00000270800|go:"GO:0042015"(interleukin-20 binding)|go:"GO:0050829"(defense response to Gram-negative bacterium)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036116|mint:Q8N6P7|rcsb pdb:3DGC|rcsb pdb:3DLQ|ensembl:ENSG00000142677(gene)|ensembl:ENST00000270800(transcript)|go:"GO:0004896"(cytokine receptor activity)|rcsb pdb:6DF3|reactome:R-HSA-8854691|go:"GO:0004904"(interferon receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019221"(cytokine-mediated signaling pathway)|refseq:NP_067081.2|dip:DIP-42031N	-	function:Cytokine that contributes to the inflammatory response in vivo|comment:mint	-	figure legend:Table 1, Fig.5|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:13.4x10^-9	2015/10/02	2015/10/12	rogid:yeLvTpHRMJWT0niv9ttASw0PkZU9606	rogid:mM7lurDGnIyLP+XnqXH5UcuqEuw9606	rigid:hx2W4qi0OQ2XZRWjyu/ZDlGfAnQ	false	-	sufficient binding region:16-228|his tag:c-c	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9GZX6	uniprotkb:Q8N6P7	intact:EBI-8040250|intact:MINT-6693924|ensembl:ENSP00000329384|ensembl:ENSP00000442424	intact:EBI-3940749|uniprotkb:Q9HB22|uniprotkb:A8K839|uniprotkb:B2R9Y9|intact:EBI-28982117|ensembl:ENSP00000270800	psi-mi:il22_human(display_long)|uniprotkb:IL22(gene name)|psi-mi:IL22(display_short)|uniprotkb:ILTIF(gene name synonym)|uniprotkb:UNQ3099/PRO10096(orf name)|uniprotkb:ZCYTO18(gene name synonym)|uniprotkb:IL-10-related T-cell-derived-inducible factor(gene name synonym)|uniprotkb:Cytokine Zcyto18(gene name synonym)	psi-mi:i22r1_human(display_long)|uniprotkb:IL22RA1(gene name)|psi-mi:IL22RA1(display_short)|uniprotkb:IL22R(gene name synonym)|uniprotkb:Cytokine receptor class-II member 9(gene name synonym)|uniprotkb:Cytokine receptor family 2 member 9(gene name synonym)|uniprotkb:ZcytoR11(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Logsdon et al. (2002)	pubmed:12513909|imex:IM-24852	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-11364281|imex:IM-24852-8	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_065386.1|dip:DIP-46035N|ensembl:ENSG00000127318(gene)|ensembl:ENST00000328087(transcript)|ensembl:ENST00000538666(transcript)|go:"GO:0005125"(cytokine activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006953"(acute-phase response)|go:"GO:0006954"(inflammatory response)|go:"GO:0045518"(interleukin-22 receptor binding)|go:"GO:0051384"(response to glucocorticoid)|interpro:IPR009079(Four-helical cytokine-like, core)|interpro:IPR020423|interpro:IPR020453|mint:Q9GZX6|rcsb pdb:1M4R|rcsb pdb:1YKB|rcsb pdb:3DGC|rcsb pdb:3DLQ|rcsb pdb:3G9V|rcsb pdb:3Q1S|reactome:R-HSA-8854691	ensembl:ENSP00000270800|go:"GO:0042015"(interleukin-20 binding)|go:"GO:0050829"(defense response to Gram-negative bacterium)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036116|mint:Q8N6P7|rcsb pdb:3DGC|rcsb pdb:3DLQ|ensembl:ENSG00000142677(gene)|ensembl:ENST00000270800(transcript)|go:"GO:0004896"(cytokine receptor activity)|rcsb pdb:6DF3|reactome:R-HSA-8854691|go:"GO:0004904"(interferon receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019221"(cytokine-mediated signaling pathway)|refseq:NP_067081.2|dip:DIP-42031N	-	function:Cytokine that contributes to the inflammatory response in vivo|comment:mint	-	figure legend:Table 1, Fig.6.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:14.9x10^-9(molar)	2015/10/02	2015/11/09	rogid:yeLvTpHRMJWT0niv9ttASw0PkZU9606	rogid:mM7lurDGnIyLP+XnqXH5UcuqEuw9606	rigid:hx2W4qi0OQ2XZRWjyu/ZDlGfAnQ	false	-	sufficient binding region:16-228|his tag:c-c	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P22301	uniprotkb:Q13651	intact:EBI-1031632|ensembl:ENSP00000412237	intact:EBI-1031656|uniprotkb:B0YJ27|uniprotkb:A8K6I0|ensembl:ENSP00000227752	psi-mi:il10_human(display_long)|uniprotkb:IL10(gene name)|psi-mi:IL10(display_short)|uniprotkb:Cytokine synthesis inhibitory factor(gene name synonym)	psi-mi:i10r1_human(display_long)|uniprotkb:IL10RA(gene name)|psi-mi:IL10RA(display_short)|uniprotkb:IL10R(gene name synonym)|uniprotkb:Interleukin-10 receptor subunit 1(gene name synonym)|uniprotkb:CDw210a(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Logsdon et al. (2002)	pubmed:12513909|imex:IM-24852	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-11364290|imex:IM-24852-9	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000563.1|go:"GO:0042742"(defense response to bacterium)|go:"GO:0042832"(defense response to protozoan)|ensembl:ENSG00000136634(gene)|ensembl:ENST00000423557(transcript)|go:"GO:0001818"(negative regulation of cytokine production)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0002237"(response to molecule of bacterial origin)|go:"GO:0002639"(positive regulation of immunoglobulin production)|go:"GO:0002719"(negative regulation of cytokine production involved in immune response)|go:"GO:0002875"(negative regulation of chronic inflammatory response to antigenic stimulus)|go:"GO:0002904"(positive regulation of B cell apoptotic process)|go:"GO:0005125"(cytokine activity)|go:"GO:0005141"(interleukin-10 receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0007253"(cytoplasmic sequestering of NF-kappaB)|go:"GO:0007568"(aging)|go:"GO:0008083"(growth factor activity)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0014823"(response to activity)|go:"GO:0014854"(response to inactivity)|go:"GO:0030097"(hemopoiesis)|go:"GO:0030183"(B cell differentiation)|go:"GO:0030595"(leukocyte chemotaxis)|go:"GO:0030886"(negative regulation of myeloid dendritic cell activation)|go:"GO:0030889"(negative regulation of B cell proliferation)|go:"GO:0032687"(negative regulation of interferon-alpha production)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032692"(negative regulation of interleukin-1 production)|go:"GO:0032695"(negative regulation of interleukin-12 production)|go:"GO:0032701"(negative regulation of interleukin-18 production)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032717"(negative regulation of interleukin-8 production)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032868"(response to insulin)|go:"GO:0034115"(negative regulation of heterotypic cell-cell adhesion)|go:"GO:0034116"(positive regulation of heterotypic cell-cell adhesion)|go:"GO:0034465"(response to carbon monoxide)|go:"GO:0035729"(cellular response to hepatocyte growth factor stimulus)|go:"GO:0042092"(type 2 immune response)|go:"GO:0042100"(B cell proliferation)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0042493"|go:"GO:0043032"(positive regulation of macrophage activation)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0045019"(negative regulation of nitric oxide biosynthetic process)|go:"GO:0045191"(regulation of isotype switching)|go:"GO:0045347"(negative regulation of MHC class II biosynthetic process)|go:"GO:0045348"(positive regulation of MHC class II biosynthetic process)|go:"GO:0045787"(positive regulation of cell cycle)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045930"(negative regulation of mitotic cell cycle)|go:"GO:0046427"(positive regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0051045"(negative regulation of membrane protein ectodomain proteolysis)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0060302"(negative regulation of cytokine activity)|go:"GO:0060670"(branching involved in labyrinthine layer morphogenesis)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071392"(cellular response to estradiol stimulus)|go:"GO:0071650"("negative regulation of chemokine (C-C motif) ligand 5 production")|go:"GO:0072577"(endothelial cell apoptotic process)|go:"GO:0097421"(liver regeneration)|go:"GO:1900100"(positive regulation of plasma cell differentiation)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1903034"(regulation of response to wounding)|go:"GO:1903208"(negative regulation of hydrogen peroxide-induced neuron death)|go:"GO:1903672"(positive regulation of sprouting angiogenesis)|go:"GO:1904057"(negative regulation of sensory perception of pain)|go:"GO:1904706"(negative regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:2000273"(positive regulation of signaling receptor activity)|interpro:IPR000098(Interleukin-10)|interpro:IPR009079(Four-helical cytokine-like, core)|interpro:IPR020423|interpro:IPR020443|rcsb pdb:1ILK|rcsb pdb:1INR|rcsb pdb:1J7V|rcsb pdb:1LK3|rcsb pdb:1Y6K|rcsb pdb:2H24|rcsb pdb:2ILK|rcsb pdb:6X93|reactome:R-HSA-6783783|reactome:R-HSA-6785807|reactome:R-HSA-8950505|reactome:R-HSA-9662834|reactome:R-HSA-9664323|dip:DIP-3511N	refseq:NP_001549.2|go:"GO:0004920"(interleukin-10 receptor activity)|ensembl:ENSG00000110324(gene)|ensembl:ENST00000227752(transcript)|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019969"(interleukin-10 binding)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0046427"(positive regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0070086"(ubiquitin-dependent endocytosis)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036116|rcsb pdb:1J7V|rcsb pdb:1LQS|rcsb pdb:1Y6K|rcsb pdb:1Y6M|rcsb pdb:1Y6N|rcsb pdb:5IXI|rcsb pdb:6X93|reactome:R-HSA-6783783|dip:DIP-3512N	-	-	-	figure legend:Table. 1, Fig. 6.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:7.2x10^-9(molar)	2015/10/02	2015/11/09	rogid:wsgbqbimYzkkLA5s2YrEyi1BClQ9606	rogid:sMAPIcNDOtzRHrmx79PMcP9jDRA9606	rigid:M8K/sxp5hA9AfPReKGbiDg8xUKo	false	mutation:134-134	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q13651	uniprotkb:P22301	intact:EBI-1031656|uniprotkb:B0YJ27|uniprotkb:A8K6I0|ensembl:ENSP00000227752	intact:EBI-1031632|ensembl:ENSP00000412237	psi-mi:i10r1_human(display_long)|uniprotkb:IL10RA(gene name)|psi-mi:IL10RA(display_short)|uniprotkb:IL10R(gene name synonym)|uniprotkb:Interleukin-10 receptor subunit 1(gene name synonym)|uniprotkb:CDw210a(gene name synonym)	psi-mi:il10_human(display_long)|uniprotkb:IL10(gene name)|psi-mi:IL10(display_short)|uniprotkb:Cytokine synthesis inhibitory factor(gene name synonym)	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)	Logsdon et al. (2002)	pubmed:12513909|imex:IM-24852	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0414"(enzymatic reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-11364398|imex:IM-24852-10	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001549.2|go:"GO:0004920"(interleukin-10 receptor activity)|ensembl:ENSG00000110324(gene)|ensembl:ENST00000227752(transcript)|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019969"(interleukin-10 binding)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0046427"(positive regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0070086"(ubiquitin-dependent endocytosis)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036116|rcsb pdb:1J7V|rcsb pdb:1LQS|rcsb pdb:1Y6K|rcsb pdb:1Y6M|rcsb pdb:1Y6N|rcsb pdb:5IXI|rcsb pdb:6X93|reactome:R-HSA-6783783|dip:DIP-3512N	refseq:NP_000563.1|go:"GO:0042742"(defense response to bacterium)|go:"GO:0042832"(defense response to protozoan)|ensembl:ENSG00000136634(gene)|ensembl:ENST00000423557(transcript)|go:"GO:0001818"(negative regulation of cytokine production)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0002237"(response to molecule of bacterial origin)|go:"GO:0002639"(positive regulation of immunoglobulin production)|go:"GO:0002719"(negative regulation of cytokine production involved in immune response)|go:"GO:0002875"(negative regulation of chronic inflammatory response to antigenic stimulus)|go:"GO:0002904"(positive regulation of B cell apoptotic process)|go:"GO:0005125"(cytokine activity)|go:"GO:0005141"(interleukin-10 receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0007253"(cytoplasmic sequestering of NF-kappaB)|go:"GO:0007568"(aging)|go:"GO:0008083"(growth factor activity)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0014823"(response to activity)|go:"GO:0014854"(response to inactivity)|go:"GO:0030097"(hemopoiesis)|go:"GO:0030183"(B cell differentiation)|go:"GO:0030595"(leukocyte chemotaxis)|go:"GO:0030886"(negative regulation of myeloid dendritic cell activation)|go:"GO:0030889"(negative regulation of B cell proliferation)|go:"GO:0032687"(negative regulation of interferon-alpha production)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032692"(negative regulation of interleukin-1 production)|go:"GO:0032695"(negative regulation of interleukin-12 production)|go:"GO:0032701"(negative regulation of interleukin-18 production)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032717"(negative regulation of interleukin-8 production)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032868"(response to insulin)|go:"GO:0034115"(negative regulation of heterotypic cell-cell adhesion)|go:"GO:0034116"(positive regulation of heterotypic cell-cell adhesion)|go:"GO:0034465"(response to carbon monoxide)|go:"GO:0035729"(cellular response to hepatocyte growth factor stimulus)|go:"GO:0042092"(type 2 immune response)|go:"GO:0042100"(B cell proliferation)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0042493"|go:"GO:0043032"(positive regulation of macrophage activation)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0045019"(negative regulation of nitric oxide biosynthetic process)|go:"GO:0045191"(regulation of isotype switching)|go:"GO:0045347"(negative regulation of MHC class II biosynthetic process)|go:"GO:0045348"(positive regulation of MHC class II biosynthetic process)|go:"GO:0045787"(positive regulation of cell cycle)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045930"(negative regulation of mitotic cell cycle)|go:"GO:0046427"(positive regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0051045"(negative regulation of membrane protein ectodomain proteolysis)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0060302"(negative regulation of cytokine activity)|go:"GO:0060670"(branching involved in labyrinthine layer morphogenesis)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071392"(cellular response to estradiol stimulus)|go:"GO:0071650"("negative regulation of chemokine (C-C motif) ligand 5 production")|go:"GO:0072577"(endothelial cell apoptotic process)|go:"GO:0097421"(liver regeneration)|go:"GO:1900100"(positive regulation of plasma cell differentiation)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1903034"(regulation of response to wounding)|go:"GO:1903208"(negative regulation of hydrogen peroxide-induced neuron death)|go:"GO:1903672"(positive regulation of sprouting angiogenesis)|go:"GO:1904057"(negative regulation of sensory perception of pain)|go:"GO:1904706"(negative regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:2000273"(positive regulation of signaling receptor activity)|interpro:IPR000098(Interleukin-10)|interpro:IPR009079(Four-helical cytokine-like, core)|interpro:IPR020423|interpro:IPR020443|rcsb pdb:1ILK|rcsb pdb:1INR|rcsb pdb:1J7V|rcsb pdb:1LK3|rcsb pdb:1Y6K|rcsb pdb:2H24|rcsb pdb:2ILK|rcsb pdb:6X93|reactome:R-HSA-6783783|reactome:R-HSA-6785807|reactome:R-HSA-8950505|reactome:R-HSA-9662834|reactome:R-HSA-9664323|dip:DIP-3511N	-	-	-	figure legend:Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:1.0x10^-9(molar)	2015/10/02	2015/11/09	rogid:sMAPIcNDOtzRHrmx79PMcP9jDRA9606	rogid:wsgbqbimYzkkLA5s2YrEyi1BClQ9606	rigid:M8K/sxp5hA9AfPReKGbiDg8xUKo	false	-	biotin tag:?-?	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)