#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P35555	uniprotkb:Q14766	intact:EBI-2505934|ensembl:ENSP00000325527|uniprotkb:B2RUU0|uniprotkb:Q15972|uniprotkb:Q75N87|uniprotkb:D2JYH6	intact:EBI-947693|uniprotkb:A1L3V1|uniprotkb:P22064|uniprotkb:Q53SD8|uniprotkb:Q53SF3|uniprotkb:Q53SG1|uniprotkb:Q59HF7|uniprotkb:Q8TD95|ensembl:ENSP00000386043	psi-mi:fbn1_human(display_long)|uniprotkb:FBN1(gene name)|psi-mi:FBN1(display_short)|uniprotkb:FBN(gene name synonym)	psi-mi:ltbp1_human(display_long)|uniprotkb:LTBP1(gene name)|psi-mi:LTBP1(display_short)|uniprotkb:Transforming growth factor beta-1-binding protein 1(gene name synonym)	psi-mi:"MI:0663"(confocal microscopy)	Isogai et al. (2003)	pubmed:12429738|imex:IM-25871	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:1335"(HPIDb)	intact:EBI-10960559|imex:IM-25871-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000166147(gene)|ensembl:ENST00000316623(transcript)|go:"GO:0001501"(skeletal system development)|go:"GO:0001527"(microfibril)|go:"GO:0001656"(metanephros development)|go:"GO:0005178"(integrin binding)|go:"GO:0005179"(hormone activity)|go:"GO:0005201"(extracellular matrix structural constituent)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005604"(basement membrane)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0007507"(heart development)|go:"GO:0008201"(heparin binding)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0010737"(protein kinase A signaling)|go:"GO:0030023"(extracellular matrix constituent conferring elasticity)|go:"GO:0031012"(extracellular matrix)|go:"GO:0033627"(cell adhesion mediated by integrin)|go:"GO:0034199"(activation of protein kinase A activity)|go:"GO:0035582"(sequestering of BMP in extracellular matrix)|go:"GO:0035583"(sequestering of TGFbeta in extracellular matrix)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043010"(camera-type eye development)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045671"(negative regulation of osteoclast differentiation)|go:"GO:0048048"(embryonic eye morphogenesis)|go:"GO:0048050"(post-embryonic eye morphogenesis)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:1990314"(cellular response to insulin-like growth factor stimulus)|go:"GO:2001205"(negative regulation of osteoclast development)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR011398(Fibrillin)|interpro:IPR017878|interpro:IPR018097|interpro:IPR026823|interpro:IPR036773|interpro:IPR040872|mint:P35555|rcsb pdb:1APJ|rcsb pdb:1EMN|rcsb pdb:1EMO|rcsb pdb:1LMJ|rcsb pdb:1UZJ|rcsb pdb:1UZK|rcsb pdb:1UZP|rcsb pdb:1UZQ|rcsb pdb:2M74|rcsb pdb:2W86|rcsb pdb:5MS9|reactome:R-HSA-1474228|reactome:R-HSA-1566948|reactome:R-HSA-2129379|reactome:R-HSA-216083|reactome:R-HSA-381426|reactome:R-HSA-8957275|refseq:NP_000129.3|dip:DIP-29985N	refseq:NP_000618.3|refseq:NP_001159736.1|refseq:NP_001159737.1|refseq:NP_001159738.1|refseq:NP_996826.2|refseq:XP_011531155.1|dip:DIP-50011N|ensembl:ENSG00000049323(gene)|ensembl:ENST00000404816(transcript)|go:"GO:0001527"(microfibril)|go:"GO:0005024"(transforming growth factor beta-activated receptor activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0031012"(extracellular matrix)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035583"(sequestering of TGFbeta in extracellular matrix)|go:"GO:0050431"(transforming growth factor beta binding)|go:"GO:0050436"(microfibril binding)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:1901388"(regulation of transforming growth factor beta activation)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR017878|interpro:IPR018097|interpro:IPR026823|interpro:IPR036773|mint:Q14766|rcsb pdb:1KSQ|reactome:R-HSA-2129379|reactome:R-HSA-381426|reactome:R-HSA-8957275	-	-	-	figure legend:4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-tendon)|taxid:9606(fetal human foot tendon)	-	2015/08/12	2019/04/15	rogid:YEO0ZRTezrjEAyTaos1pm2hUDXg9606	rogid:OgHGfOcQWdQuLUT85Xg04lfggcs9606	rigid:jSqGIst23kWccDajDy5ydKV1vXw	false	-	-	-	-	psi-mi:"MI:0422"(immunostaining)	psi-mi:"MI:0422"(immunostaining)
uniprotkb:P01137	uniprotkb:Q14766	intact:EBI-779636|uniprotkb:Q9UCG4|uniprotkb:A8K792	intact:EBI-947693|uniprotkb:A1L3V1|uniprotkb:P22064|uniprotkb:Q53SD8|uniprotkb:Q53SF3|uniprotkb:Q53SG1|uniprotkb:Q59HF7|uniprotkb:Q8TD95|ensembl:ENSP00000386043	psi-mi:tgfb1_human(display_long)|uniprotkb:TGFB1(gene name)|psi-mi:TGFB1(display_short)|uniprotkb:TGFB(gene name synonym)	psi-mi:ltbp1_human(display_long)|uniprotkb:LTBP1(gene name)|psi-mi:LTBP1(display_short)|uniprotkb:Transforming growth factor beta-1-binding protein 1(gene name synonym)	psi-mi:"MI:0071"(molecular sieving)	Isogai et al. (2003)	pubmed:12429738|imex:IM-25871	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:1335"(HPIDb)	intact:EBI-10960569|imex:IM-25871-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000651.3|mint:P01137|dip:DIP-5934N|go:"GO:0000165"(MAPK cascade)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0001843"(neural tube closure)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002062"(chondrocyte differentiation)|go:"GO:0002244"(hematopoietic progenitor cell differentiation)|go:"GO:0002248"(connective tissue replacement involved in inflammatory response wound healing)|go:"GO:0003179"(heart valve morphogenesis)|go:"GO:0003180"(aortic valve morphogenesis)|go:"GO:0003823"(antigen binding)|go:"GO:0005114"(type II transforming growth factor beta receptor binding)|go:"GO:0005125"(cytokine activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005796"(Golgi lumen)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006611"(protein export from nucleus)|go:"GO:0006754"(ATP biosynthetic process)|go:"GO:0006796"(phosphate-containing compound metabolic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007182"(common-partner SMAD protein phosphorylation)|go:"GO:0007183"(SMAD protein complex assembly)|go:"GO:0007435"(salivary gland morphogenesis)|go:"GO:0007507"(heart development)|go:"GO:0008083"(growth factor activity)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009611"(response to wounding)|go:"GO:0009986"(cell surface)|go:"GO:0010575"(positive regulation of vascular endothelial growth factor production)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010716"(negative regulation of extracellular matrix disassembly)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0010742"(macrophage derived foam cell differentiation)|go:"GO:0010763"(positive regulation of fibroblast migration)|go:"GO:0010800"(positive regulation of peptidyl-threonine phosphorylation)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0010936"(negative regulation of macrophage cytokine production)|go:"GO:0014008"(positive regulation of microglia differentiation)|go:"GO:0016202"(regulation of striated muscle tissue development)|go:"GO:0016477"(cell migration)|go:"GO:0017015"(regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0019899"(enzyme binding)|go:"GO:0021915"(neural tube development)|go:"GO:0022408"(negative regulation of cell-cell adhesion)|go:"GO:0030214"(hyaluronan catabolic process)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0031012"(extracellular matrix)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0031293"(membrane protein intracellular domain proteolysis)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032270"(positive regulation of cellular protein metabolic process)|go:"GO:0032355"(response to estradiol)|go:"GO:0032570"(response to progesterone)|go:"GO:0032740"(positive regulation of interleukin-17 production)|go:"GO:0032801"(receptor catabolic process)|go:"GO:0032930"(positive regulation of superoxide anion generation)|go:"GO:0032967"(positive regulation of collagen biosynthetic process)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034713"(type I transforming growth factor beta receptor binding)|go:"GO:0034714"(type III transforming growth factor beta receptor binding)|go:"GO:0035307"(positive regulation of protein dephosphorylation)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042306"(regulation of protein import into nucleus)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042802"(identical protein binding)|go:"GO:0043117"(positive regulation of vascular permeability)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0043537"(negative regulation of blood vessel endothelial cell migration)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0043932"(ossification involved in bone remodeling)|go:"GO:0045216"(cell-cell junction organization)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0045662"(negative regulation of myoblast differentiation)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045918"(negative regulation of cytolysis)|go:"GO:0045930"(negative regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048298"(positive regulation of isotype switching to IgA isotypes)|go:"GO:0048535"(lymph node development)|go:"GO:0048642"(negative regulation of skeletal muscle tissue development)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050921"(positive regulation of chemotaxis)|go:"GO:0051098"(regulation of binding)|go:"GO:0051101"(regulation of DNA binding)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051781"(positive regulation of cell division)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0055010"(ventricular cardiac muscle tissue morphogenesis)|go:"GO:0060312"(regulation of blood vessel remodeling)|go:"GO:0060389"(pathway-restricted SMAD protein phosphorylation)|go:"GO:0060390"(regulation of SMAD protein signal transduction)|go:"GO:0060391"(positive regulation of SMAD protein signal transduction)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0060965"(negative regulation of gene silencing by miRNA)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070168"(negative regulation of biomineral tissue development)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070723"(response to cholesterol)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0072562"(blood microparticle)|go:"GO:0085029"(extracellular matrix assembly)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:1900126"(negative regulation of hyaluronan biosynthetic process)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1901203"(positive regulation of extracellular matrix assembly)|go:"GO:1901666"(positive regulation of NAD+ ADP-ribosyltransferase activity)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1903077"(negative regulation of protein localization to plasma membrane)|go:"GO:1903799"(negative regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1903800"(positive regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1904894"(positive regulation of receptor signaling pathway via STAT)|go:"GO:1905313"(transforming growth factor beta receptor signaling pathway involved in heart development)|go:"GO:1990402"(embryonic liver development)|go:"GO:2000679"(positive regulation of transcription regulatory region DNA binding)|go:"GO:2000727"(positive regulation of cardiac muscle cell differentiation)|interpro:IPR001111("Transforming growth factor beta (TGFb), N-terminal")|interpro:IPR001839(Transforming growth factor beta)|interpro:IPR003939(Transforming growth factor, beta 1)|interpro:IPR015615(Transforming growth factor-beta-related)|interpro:IPR016319(Transforming growth factor-beta)|interpro:IPR017948|interpro:IPR029034|rcsb pdb:1KLA|rcsb pdb:1KLC|rcsb pdb:1KLD|rcsb pdb:3KFD|rcsb pdb:4KV5|rcsb pdb:5FFO|rcsb pdb:5VQP|rcsb pdb:6OM2|rcsb pdb:6P7J|reactome:R-HSA-114608|reactome:R-HSA-168277|reactome:R-HSA-202733|reactome:R-HSA-2129379|reactome:R-HSA-2173788|reactome:R-HSA-2173789|reactome:R-HSA-2173791|reactome:R-HSA-3000170|reactome:R-HSA-3000178|reactome:R-HSA-3304356|reactome:R-HSA-3642279|reactome:R-HSA-3645790|reactome:R-HSA-3656532|reactome:R-HSA-3656535|reactome:R-HSA-381340|reactome:R-HSA-5689603|reactome:R-HSA-6785807|reactome:R-HSA-8941855|reactome:R-HSA-8941858|reactome:R-HSA-8951936	refseq:NP_000618.3|refseq:NP_001159736.1|refseq:NP_001159737.1|refseq:NP_001159738.1|refseq:NP_996826.2|refseq:XP_011531155.1|dip:DIP-50011N|ensembl:ENSG00000049323(gene)|ensembl:ENST00000404816(transcript)|go:"GO:0001527"(microfibril)|go:"GO:0005024"(transforming growth factor beta-activated receptor activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0031012"(extracellular matrix)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035583"(sequestering of TGFbeta in extracellular matrix)|go:"GO:0050431"(transforming growth factor beta binding)|go:"GO:0050436"(microfibril binding)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:1901388"(regulation of transforming growth factor beta activation)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR017878|interpro:IPR018097|interpro:IPR026823|interpro:IPR036773|mint:Q14766|rcsb pdb:1KSQ|reactome:R-HSA-2129379|reactome:R-HSA-381426|reactome:R-HSA-8957275	-	-	-	figure legend:7B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-skin)|taxid:9606(Homo sapiens skin)	-	2015/08/12	2015/08/17	rogid:WjHm8ysG9Ab1pFfdtG9QbJeCdCw9606	rogid:OgHGfOcQWdQuLUT85Xg04lfggcs9606	rigid:lDLvvM0GF8L+qjMcen0blZTTwlQ	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P35555	uniprotkb:Q14766-2	intact:EBI-2505934|ensembl:ENSP00000325527|uniprotkb:B2RUU0|uniprotkb:Q15972|uniprotkb:Q75N87|uniprotkb:D2JYH6	intact:EBI-11173832|uniprotkb:P22064-1|ensembl:ENSP00000384091	psi-mi:fbn1_human(display_long)|uniprotkb:FBN1(gene name)|psi-mi:FBN1(display_short)|uniprotkb:FBN(gene name synonym)	psi-mi:q14766-2(display_long)|uniprotkb:LTBP1(gene name)|psi-mi:LTBP1(display_short)|uniprotkb:Transforming growth factor beta-1-binding protein 1(gene name synonym)|uniprotkb:LTBP-1S(isoform synonym)	psi-mi:"MI:0047"(far western blotting)	Isogai et al. (2003)	pubmed:12429738|imex:IM-25871	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:1335"(HPIDb)	intact:EBI-10960581|imex:IM-25871-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000166147(gene)|ensembl:ENST00000316623(transcript)|go:"GO:0001501"(skeletal system development)|go:"GO:0001527"(microfibril)|go:"GO:0001656"(metanephros development)|go:"GO:0005178"(integrin binding)|go:"GO:0005179"(hormone activity)|go:"GO:0005201"(extracellular matrix structural constituent)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005604"(basement membrane)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0007507"(heart development)|go:"GO:0008201"(heparin binding)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0010737"(protein kinase A signaling)|go:"GO:0030023"(extracellular matrix constituent conferring elasticity)|go:"GO:0031012"(extracellular matrix)|go:"GO:0033627"(cell adhesion mediated by integrin)|go:"GO:0034199"(activation of protein kinase A activity)|go:"GO:0035582"(sequestering of BMP in extracellular matrix)|go:"GO:0035583"(sequestering of TGFbeta in extracellular matrix)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043010"(camera-type eye development)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045671"(negative regulation of osteoclast differentiation)|go:"GO:0048048"(embryonic eye morphogenesis)|go:"GO:0048050"(post-embryonic eye morphogenesis)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:1990314"(cellular response to insulin-like growth factor stimulus)|go:"GO:2001205"(negative regulation of osteoclast development)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR011398(Fibrillin)|interpro:IPR017878|interpro:IPR018097|interpro:IPR026823|interpro:IPR036773|interpro:IPR040872|mint:P35555|rcsb pdb:1APJ|rcsb pdb:1EMN|rcsb pdb:1EMO|rcsb pdb:1LMJ|rcsb pdb:1UZJ|rcsb pdb:1UZK|rcsb pdb:1UZP|rcsb pdb:1UZQ|rcsb pdb:2M74|rcsb pdb:2W86|rcsb pdb:5MS9|reactome:R-HSA-1474228|reactome:R-HSA-1566948|reactome:R-HSA-2129379|reactome:R-HSA-216083|reactome:R-HSA-381426|reactome:R-HSA-8957275|refseq:NP_000129.3|dip:DIP-29985N	intact:EBI-947693(isoform-parent)|ensembl:ENSG00000049323(gene)|ensembl:ENST00000407925(transcript)	-	-	-	figure legend:8A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2015/08/12	2019/04/15	rogid:YEO0ZRTezrjEAyTaos1pm2hUDXg9606	rogid:XPmLHb6R3/xxqjPuAjuarIjhM009606	rigid:f9XO+sHJ2XPeJuAetN5b331DYoQ	false	sufficient binding region:45-550..550	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P35556-1	uniprotkb:Q14766-2	intact:EBI-11178547|ensembl:ENSP00000262464|ensembl:ENSP00000424571	intact:EBI-11173832|uniprotkb:P22064-1|ensembl:ENSP00000384091	psi-mi:p35556-1(display_long)|uniprotkb:FBN2(gene name)|psi-mi:FBN2(display_short)	psi-mi:q14766-2(display_long)|uniprotkb:LTBP1(gene name)|psi-mi:LTBP1(display_short)|uniprotkb:Transforming growth factor beta-1-binding protein 1(gene name synonym)|uniprotkb:LTBP-1S(isoform synonym)	psi-mi:"MI:0047"(far western blotting)	Isogai et al. (2003)	pubmed:12429738|imex:IM-25871	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:1335"(HPIDb)	intact:EBI-10960587|imex:IM-25871-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000138829(gene)|ensembl:ENST00000262464(transcript)|ensembl:ENST00000508053(transcript)|intact:EBI-6164392(isoform-parent)	intact:EBI-947693(isoform-parent)|ensembl:ENSG00000049323(gene)|ensembl:ENST00000407925(transcript)	-	-	-	figure legend:8B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2015/08/12	2015/09/17	rogid:iqBnjHuy9kU3serIc5tPWGIDzUc9606	rogid:XPmLHb6R3/xxqjPuAjuarIjhM009606	rigid:Djf0tzwiRf1TfkIgai5yOpV2VKk	false	sufficient binding region:145-359	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P35555	uniprotkb:Q14766-2	intact:EBI-2505934|ensembl:ENSP00000325527|uniprotkb:B2RUU0|uniprotkb:Q15972|uniprotkb:Q75N87|uniprotkb:D2JYH6	intact:EBI-11173832|uniprotkb:P22064-1|ensembl:ENSP00000384091	psi-mi:fbn1_human(display_long)|uniprotkb:FBN1(gene name)|psi-mi:FBN1(display_short)|uniprotkb:FBN(gene name synonym)	psi-mi:q14766-2(display_long)|uniprotkb:LTBP1(gene name)|psi-mi:LTBP1(display_short)|uniprotkb:Transforming growth factor beta-1-binding protein 1(gene name synonym)|uniprotkb:LTBP-1S(isoform synonym)	psi-mi:"MI:0047"(far western blotting)	Isogai et al. (2003)	pubmed:12429738|imex:IM-25871	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:1335"(HPIDb)	intact:EBI-11173845|imex:IM-25871-15	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000166147(gene)|ensembl:ENST00000316623(transcript)|go:"GO:0001501"(skeletal system development)|go:"GO:0001527"(microfibril)|go:"GO:0001656"(metanephros development)|go:"GO:0005178"(integrin binding)|go:"GO:0005179"(hormone activity)|go:"GO:0005201"(extracellular matrix structural constituent)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005604"(basement membrane)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0007507"(heart development)|go:"GO:0008201"(heparin binding)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0010737"(protein kinase A signaling)|go:"GO:0030023"(extracellular matrix constituent conferring elasticity)|go:"GO:0031012"(extracellular matrix)|go:"GO:0033627"(cell adhesion mediated by integrin)|go:"GO:0034199"(activation of protein kinase A activity)|go:"GO:0035582"(sequestering of BMP in extracellular matrix)|go:"GO:0035583"(sequestering of TGFbeta in extracellular matrix)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043010"(camera-type eye development)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045671"(negative regulation of osteoclast differentiation)|go:"GO:0048048"(embryonic eye morphogenesis)|go:"GO:0048050"(post-embryonic eye morphogenesis)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:1990314"(cellular response to insulin-like growth factor stimulus)|go:"GO:2001205"(negative regulation of osteoclast development)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR011398(Fibrillin)|interpro:IPR017878|interpro:IPR018097|interpro:IPR026823|interpro:IPR036773|interpro:IPR040872|mint:P35555|rcsb pdb:1APJ|rcsb pdb:1EMN|rcsb pdb:1EMO|rcsb pdb:1LMJ|rcsb pdb:1UZJ|rcsb pdb:1UZK|rcsb pdb:1UZP|rcsb pdb:1UZQ|rcsb pdb:2M74|rcsb pdb:2W86|rcsb pdb:5MS9|reactome:R-HSA-1474228|reactome:R-HSA-1566948|reactome:R-HSA-2129379|reactome:R-HSA-216083|reactome:R-HSA-381426|reactome:R-HSA-8957275|refseq:NP_000129.3|dip:DIP-29985N	intact:EBI-947693(isoform-parent)|ensembl:ENSG00000049323(gene)|ensembl:ENST00000407925(transcript)	-	-	-	figure legend:8A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2015/08/12	2019/04/15	rogid:YEO0ZRTezrjEAyTaos1pm2hUDXg9606	rogid:XPmLHb6R3/xxqjPuAjuarIjhM009606	rigid:f9XO+sHJ2XPeJuAetN5b331DYoQ	false	his tag:c-c|sufficient binding region:115-287	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P35556-1	uniprotkb:Q14766-1	intact:EBI-11178547|ensembl:ENSP00000262464|ensembl:ENSP00000424571	intact:EBI-11173861|ensembl:ENSP00000386043	psi-mi:p35556-1(display_long)|uniprotkb:FBN2(gene name)|psi-mi:FBN2(display_short)	psi-mi:q14766-1(display_long)|uniprotkb:LTBP1(gene name)|psi-mi:LTBP1(display_short)|uniprotkb:Transforming growth factor beta-1-binding protein 1(gene name synonym)|uniprotkb:LTBP-1L(isoform synonym)	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)	Isogai et al. (2003)	pubmed:12429738|imex:IM-25871	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1335"(HPIDb)	intact:EBI-10960605|imex:IM-25871-11	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000138829(gene)|ensembl:ENST00000262464(transcript)|ensembl:ENST00000508053(transcript)|intact:EBI-6164392(isoform-parent)	intact:EBI-947693(isoform-parent)|ensembl:ENSG00000049323(gene)|ensembl:ENST00000404816(transcript)	-	-	-	figure legend:9A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2015/08/12	2015/09/16	rogid:iqBnjHuy9kU3serIc5tPWGIDzUc9606	rogid:OgHGfOcQWdQuLUT85Xg04lfggcs9606	rigid:YY1SlmNG+29si8CVkFSi3VPBCDk	false	sufficient binding region:145-996..1135	sufficient binding region:915-1466	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:P35555	uniprotkb:Q14766-1	intact:EBI-2505934|ensembl:ENSP00000325527|uniprotkb:B2RUU0|uniprotkb:Q15972|uniprotkb:Q75N87|uniprotkb:D2JYH6	intact:EBI-11173861|ensembl:ENSP00000386043	psi-mi:fbn1_human(display_long)|uniprotkb:FBN1(gene name)|psi-mi:FBN1(display_short)|uniprotkb:FBN(gene name synonym)	psi-mi:q14766-1(display_long)|uniprotkb:LTBP1(gene name)|psi-mi:LTBP1(display_short)|uniprotkb:Transforming growth factor beta-1-binding protein 1(gene name synonym)|uniprotkb:LTBP-1L(isoform synonym)	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)	Isogai et al. (2003)	pubmed:12429738|imex:IM-25871	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1335"(HPIDb)	intact:EBI-10960599|imex:IM-25871-9	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000166147(gene)|ensembl:ENST00000316623(transcript)|go:"GO:0001501"(skeletal system development)|go:"GO:0001527"(microfibril)|go:"GO:0001656"(metanephros development)|go:"GO:0005178"(integrin binding)|go:"GO:0005179"(hormone activity)|go:"GO:0005201"(extracellular matrix structural constituent)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005604"(basement membrane)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0007507"(heart development)|go:"GO:0008201"(heparin binding)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0010737"(protein kinase A signaling)|go:"GO:0030023"(extracellular matrix constituent conferring elasticity)|go:"GO:0031012"(extracellular matrix)|go:"GO:0033627"(cell adhesion mediated by integrin)|go:"GO:0034199"(activation of protein kinase A activity)|go:"GO:0035582"(sequestering of BMP in extracellular matrix)|go:"GO:0035583"(sequestering of TGFbeta in extracellular matrix)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043010"(camera-type eye development)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045671"(negative regulation of osteoclast differentiation)|go:"GO:0048048"(embryonic eye morphogenesis)|go:"GO:0048050"(post-embryonic eye morphogenesis)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:1990314"(cellular response to insulin-like growth factor stimulus)|go:"GO:2001205"(negative regulation of osteoclast development)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR011398(Fibrillin)|interpro:IPR017878|interpro:IPR018097|interpro:IPR026823|interpro:IPR036773|interpro:IPR040872|mint:P35555|rcsb pdb:1APJ|rcsb pdb:1EMN|rcsb pdb:1EMO|rcsb pdb:1LMJ|rcsb pdb:1UZJ|rcsb pdb:1UZK|rcsb pdb:1UZP|rcsb pdb:1UZQ|rcsb pdb:2M74|rcsb pdb:2W86|rcsb pdb:5MS9|reactome:R-HSA-1474228|reactome:R-HSA-1566948|reactome:R-HSA-2129379|reactome:R-HSA-216083|reactome:R-HSA-381426|reactome:R-HSA-8957275|refseq:NP_000129.3|dip:DIP-29985N	intact:EBI-947693(isoform-parent)|ensembl:ENSG00000049323(gene)|ensembl:ENST00000404816(transcript)	-	-	-	figure legend:9|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2015/08/12	2019/04/15	rogid:YEO0ZRTezrjEAyTaos1pm2hUDXg9606	rogid:OgHGfOcQWdQuLUT85Xg04lfggcs9606	rigid:jSqGIst23kWccDajDy5ydKV1vXw	false	his tag:c-c|sufficient binding region:19-489	sufficient binding region:1508-1721	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:Q8N2S1-3	uniprotkb:P35555	intact:EBI-11178559	intact:EBI-2505934|ensembl:ENSP00000325527|uniprotkb:B2RUU0|uniprotkb:Q15972|uniprotkb:Q75N87|uniprotkb:D2JYH6	psi-mi:q8n2s1-3(display_long)|uniprotkb:LTBP4(gene name)|psi-mi:LTBP4(display_short)	psi-mi:fbn1_human(display_long)|uniprotkb:FBN1(gene name)|psi-mi:FBN1(display_short)|uniprotkb:FBN(gene name synonym)	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)	Isogai et al. (2003)	pubmed:12429738|imex:IM-25871	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1335"(HPIDb)	intact:EBI-10961119|imex:IM-25871-13	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-947718(isoform-parent)|uniprotkb:Q8N2S1-3(isoform-parent)	ensembl:ENSG00000166147(gene)|ensembl:ENST00000316623(transcript)|go:"GO:0001501"(skeletal system development)|go:"GO:0001527"(microfibril)|go:"GO:0001656"(metanephros development)|go:"GO:0005178"(integrin binding)|go:"GO:0005179"(hormone activity)|go:"GO:0005201"(extracellular matrix structural constituent)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005604"(basement membrane)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0007507"(heart development)|go:"GO:0008201"(heparin binding)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0010737"(protein kinase A signaling)|go:"GO:0030023"(extracellular matrix constituent conferring elasticity)|go:"GO:0031012"(extracellular matrix)|go:"GO:0033627"(cell adhesion mediated by integrin)|go:"GO:0034199"(activation of protein kinase A activity)|go:"GO:0035582"(sequestering of BMP in extracellular matrix)|go:"GO:0035583"(sequestering of TGFbeta in extracellular matrix)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043010"(camera-type eye development)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045671"(negative regulation of osteoclast differentiation)|go:"GO:0048048"(embryonic eye morphogenesis)|go:"GO:0048050"(post-embryonic eye morphogenesis)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:1990314"(cellular response to insulin-like growth factor stimulus)|go:"GO:2001205"(negative regulation of osteoclast development)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR011398(Fibrillin)|interpro:IPR017878|interpro:IPR018097|interpro:IPR026823|interpro:IPR036773|interpro:IPR040872|mint:P35555|rcsb pdb:1APJ|rcsb pdb:1EMN|rcsb pdb:1EMO|rcsb pdb:1LMJ|rcsb pdb:1UZJ|rcsb pdb:1UZK|rcsb pdb:1UZP|rcsb pdb:1UZQ|rcsb pdb:2M74|rcsb pdb:2W86|rcsb pdb:5MS9|reactome:R-HSA-1474228|reactome:R-HSA-1566948|reactome:R-HSA-2129379|reactome:R-HSA-216083|reactome:R-HSA-381426|reactome:R-HSA-8957275|refseq:NP_000129.3|dip:DIP-29985N	-	-	-	figure legend:9B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2015/08/12	2019/04/15	rogid:xCF8r6BytL1OXrThvAjTFUM2C9E9606	rogid:YEO0ZRTezrjEAyTaos1pm2hUDXg9606	rigid:lS6Tig+TFlaafK4uuyxdHXqNAIE	false	his tag:c-c|sufficient binding region:1301-1587	sufficient binding region:1-489	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)