#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P37090	uniprotkb:P37089	intact:EBI-11422032|uniprotkb:O09183	intact:EBI-11422003|uniprotkb:Q64593|uniprotkb:Q9QUI4	psi-mi:scnnb_rat(display_long)|uniprotkb:Scnn1b(gene name)|psi-mi:Scnn1b(display_short)|uniprotkb:Beta-NaCH(gene name synonym)|uniprotkb:"Epithelial Na(+) channel subunit beta"(gene name synonym)|uniprotkb:Nonvoltage-gated sodium channel 1 subunit beta(gene name synonym)|uniprotkb:SCNEB(gene name synonym)	psi-mi:scnna_rat(display_long)|uniprotkb:Scnn1a(gene name)|psi-mi:Scnn1a(display_short)|uniprotkb:Renac(gene name synonym)|uniprotkb:Alpha-NaCH(gene name synonym)|uniprotkb:"Epithelial Na(+) channel subunit alpha"(gene name synonym)|uniprotkb:Nonvoltage-gated sodium channel 1 subunit alpha(gene name synonym)|uniprotkb:SCNEA(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Dijkink et al. (2002)	pubmed:12136275|imex:IM-24733	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-11422057|imex:IM-24733-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_036780.1|rcsb pdb:1I5H|interpro:IPR004724(Epithelial sodium channel)|interpro:IPR001873(Na+ channel, amiloride-sensitive)|interpro:IPR020903|rgd:3640|reactome:R-RNO-2672351|go:"GO:0001666"(response to hypoxia)|go:"GO:0002028"(regulation of sodium ion transport)|go:"GO:0002269"(leukocyte activation involved in inflammatory response)|go:"GO:0002283"(neutrophil activation involved in immune response)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006814"(sodium ion transport)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010467"(gene expression)|go:"GO:0014824"(artery smooth muscle contraction)|go:"GO:0015280"(ligand-gated sodium channel activity)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0032094"(response to food)|go:"GO:0032341"(aldosterone metabolic process)|go:"GO:0034101"(erythrocyte homeostasis)|go:"GO:0034706"(sodium channel complex)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0035313"(wound healing, spreading of epidermal cells)|go:"GO:0035725"(sodium ion transmembrane transport)|go:"GO:0042045"(epithelial fluid transport)|go:"GO:0042493"|go:"GO:0050699"(WW domain binding)|go:"GO:0050891"(multicellular organismal water homeostasis)|go:"GO:0050909"(sensory perception of taste)|go:"GO:0055075"(potassium ion homeostasis)|go:"GO:0055078"(sodium ion homeostasis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070254"(mucus secretion)|go:"GO:0070944"(neutrophil-mediated killing of bacterium)|go:"GO:0097274"(urea homeostasis)|go:"GO:0098797"(plasma membrane protein complex)|go:"GO:1904045"(cellular response to aldosterone)|go:"GO:0016324"(apical plasma membrane)	rgd:3639|refseq:NP_113736.1|reactome:R-RNO-2672351|go:"GO:0055078"(sodium ion homeostasis)|go:"GO:0060170"(ciliary membrane)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097228"(sperm principal piece)|go:"GO:0098797"(plasma membrane protein complex)|go:"GO:1904045"(cellular response to aldosterone)|interpro:IPR001873(Na+ channel, amiloride-sensitive)|interpro:IPR004724(Epithelial sodium channel)|interpro:IPR020903|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006814"(sodium ion transport)|go:"GO:0008217"(regulation of blood pressure)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0015280"(ligand-gated sodium channel activity)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030864"(cortical actin cytoskeleton)|go:"GO:0031514"(motile cilium)|go:"GO:0034706"(sodium channel complex)|go:"GO:0035725"(sodium ion transmembrane transport)|go:"GO:0050699"(WW domain binding)|go:"GO:0003779"(actin binding)|go:"GO:0050878"(regulation of body fluid levels)|go:"GO:0050891"(multicellular organismal water homeostasis)|go:"GO:0050909"(sensory perception of taste)|dip:DIP-61308N	-	-	-	figure legend:Fig. 6|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:8355(xenla-oocyte)|taxid:8355(Xenopus laevis)	-	2015/11/23	2015/11/23	rogid:A1/XuCa48PaklR0agTX87dVmyTE10116	rogid:aOr+GNSM52kchmieeS16ZnQT5MM10116	rigid:YpTGnbqGBKL1AjKay3G1o9lBgTo	false	-	flag tag:194-201	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P37090	uniprotkb:P37091	intact:EBI-11422032|uniprotkb:O09183	intact:EBI-11422068	psi-mi:scnnb_rat(display_long)|uniprotkb:Scnn1b(gene name)|psi-mi:Scnn1b(display_short)|uniprotkb:Beta-NaCH(gene name synonym)|uniprotkb:"Epithelial Na(+) channel subunit beta"(gene name synonym)|uniprotkb:Nonvoltage-gated sodium channel 1 subunit beta(gene name synonym)|uniprotkb:SCNEB(gene name synonym)	psi-mi:scnng_rat(display_long)|uniprotkb:Scnn1g(gene name)|psi-mi:Scnn1g(display_short)|uniprotkb:"Epithelial Na(+) channel subunit gamma"(gene name synonym)|uniprotkb:Gamma-NaCH(gene name synonym)|uniprotkb:Nonvoltage-gated sodium channel 1 subunit gamma(gene name synonym)|uniprotkb:SCNEG(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Dijkink et al. (2002)	pubmed:12136275|imex:IM-24733	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-11422064|imex:IM-24733-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_036780.1|rcsb pdb:1I5H|interpro:IPR004724(Epithelial sodium channel)|interpro:IPR001873(Na+ channel, amiloride-sensitive)|interpro:IPR020903|rgd:3640|reactome:R-RNO-2672351|go:"GO:0001666"(response to hypoxia)|go:"GO:0002028"(regulation of sodium ion transport)|go:"GO:0002269"(leukocyte activation involved in inflammatory response)|go:"GO:0002283"(neutrophil activation involved in immune response)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006814"(sodium ion transport)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010467"(gene expression)|go:"GO:0014824"(artery smooth muscle contraction)|go:"GO:0015280"(ligand-gated sodium channel activity)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0032094"(response to food)|go:"GO:0032341"(aldosterone metabolic process)|go:"GO:0034101"(erythrocyte homeostasis)|go:"GO:0034706"(sodium channel complex)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0035313"(wound healing, spreading of epidermal cells)|go:"GO:0035725"(sodium ion transmembrane transport)|go:"GO:0042045"(epithelial fluid transport)|go:"GO:0042493"|go:"GO:0050699"(WW domain binding)|go:"GO:0050891"(multicellular organismal water homeostasis)|go:"GO:0050909"(sensory perception of taste)|go:"GO:0055075"(potassium ion homeostasis)|go:"GO:0055078"(sodium ion homeostasis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070254"(mucus secretion)|go:"GO:0070944"(neutrophil-mediated killing of bacterium)|go:"GO:0097274"(urea homeostasis)|go:"GO:0098797"(plasma membrane protein complex)|go:"GO:1904045"(cellular response to aldosterone)|go:"GO:0016324"(apical plasma membrane)	refseq:NP_058742.1|rgd:3641|reactome:R-RNO-2672351|go:"GO:0005216"(ion channel activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006814"(sodium ion transport)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0015280"(ligand-gated sodium channel activity)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0034706"(sodium channel complex)|go:"GO:0035313"(wound healing, spreading of epidermal cells)|go:"GO:0035725"(sodium ion transmembrane transport)|go:"GO:0050699"(WW domain binding)|go:"GO:0050891"(multicellular organismal water homeostasis)|go:"GO:0050909"(sensory perception of taste)|go:"GO:0055078"(sodium ion homeostasis)|go:"GO:0001666"(response to hypoxia)|go:"GO:0098797"(plasma membrane protein complex)|go:"GO:0070062"(extracellular exosome)|go:"GO:1904045"(cellular response to aldosterone)|interpro:IPR001873(Na+ channel, amiloride-sensitive)|interpro:IPR004724(Epithelial sodium channel)|interpro:IPR020903|dip:DIP-61327N	-	-	-	figure legend:Fig. 6|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:8355(xenla-oocyte)|taxid:8355(Xenopus laevis)	-	2015/11/23	2015/11/23	rogid:A1/XuCa48PaklR0agTX87dVmyTE10116	rogid:wb7e4GCC3aQvSwp9ZhesBaMo4ak10116	rigid:thqe+VFU/0cINnkZWsjj3V1R+9g	false	-	flag tag:142-149	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P37089	uniprotkb:P37090	intact:EBI-11422003|uniprotkb:Q64593|uniprotkb:Q9QUI4	intact:EBI-11422032|uniprotkb:O09183	psi-mi:scnna_rat(display_long)|uniprotkb:Scnn1a(gene name)|psi-mi:Scnn1a(display_short)|uniprotkb:Renac(gene name synonym)|uniprotkb:Alpha-NaCH(gene name synonym)|uniprotkb:"Epithelial Na(+) channel subunit alpha"(gene name synonym)|uniprotkb:Nonvoltage-gated sodium channel 1 subunit alpha(gene name synonym)|uniprotkb:SCNEA(gene name synonym)	psi-mi:scnnb_rat(display_long)|uniprotkb:Scnn1b(gene name)|psi-mi:Scnn1b(display_short)|uniprotkb:Beta-NaCH(gene name synonym)|uniprotkb:"Epithelial Na(+) channel subunit beta"(gene name synonym)|uniprotkb:Nonvoltage-gated sodium channel 1 subunit beta(gene name synonym)|uniprotkb:SCNEB(gene name synonym)	psi-mi:"MI:0071"(molecular sieving)	Dijkink et al. (2002)	pubmed:12136275|imex:IM-24733	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0469"(IntAct)	intact:EBI-11422098|imex:IM-24733-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:3639|refseq:NP_113736.1|reactome:R-RNO-2672351|go:"GO:0055078"(sodium ion homeostasis)|go:"GO:0060170"(ciliary membrane)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097228"(sperm principal piece)|go:"GO:0098797"(plasma membrane protein complex)|go:"GO:1904045"(cellular response to aldosterone)|interpro:IPR001873(Na+ channel, amiloride-sensitive)|interpro:IPR004724(Epithelial sodium channel)|interpro:IPR020903|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006814"(sodium ion transport)|go:"GO:0008217"(regulation of blood pressure)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0015280"(ligand-gated sodium channel activity)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030864"(cortical actin cytoskeleton)|go:"GO:0031514"(motile cilium)|go:"GO:0034706"(sodium channel complex)|go:"GO:0035725"(sodium ion transmembrane transport)|go:"GO:0050699"(WW domain binding)|go:"GO:0003779"(actin binding)|go:"GO:0050878"(regulation of body fluid levels)|go:"GO:0050891"(multicellular organismal water homeostasis)|go:"GO:0050909"(sensory perception of taste)|dip:DIP-61308N	refseq:NP_036780.1|rcsb pdb:1I5H|interpro:IPR004724(Epithelial sodium channel)|interpro:IPR001873(Na+ channel, amiloride-sensitive)|interpro:IPR020903|rgd:3640|reactome:R-RNO-2672351|go:"GO:0001666"(response to hypoxia)|go:"GO:0002028"(regulation of sodium ion transport)|go:"GO:0002269"(leukocyte activation involved in inflammatory response)|go:"GO:0002283"(neutrophil activation involved in immune response)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006814"(sodium ion transport)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010467"(gene expression)|go:"GO:0014824"(artery smooth muscle contraction)|go:"GO:0015280"(ligand-gated sodium channel activity)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0032094"(response to food)|go:"GO:0032341"(aldosterone metabolic process)|go:"GO:0034101"(erythrocyte homeostasis)|go:"GO:0034706"(sodium channel complex)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0035313"(wound healing, spreading of epidermal cells)|go:"GO:0035725"(sodium ion transmembrane transport)|go:"GO:0042045"(epithelial fluid transport)|go:"GO:0042493"|go:"GO:0050699"(WW domain binding)|go:"GO:0050891"(multicellular organismal water homeostasis)|go:"GO:0050909"(sensory perception of taste)|go:"GO:0055075"(potassium ion homeostasis)|go:"GO:0055078"(sodium ion homeostasis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070254"(mucus secretion)|go:"GO:0070944"(neutrophil-mediated killing of bacterium)|go:"GO:0097274"(urea homeostasis)|go:"GO:0098797"(plasma membrane protein complex)|go:"GO:1904045"(cellular response to aldosterone)|go:"GO:0016324"(apical plasma membrane)	-	-	-	figure legend:Fig.s 1 & 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:8355(xenla-oocyte)|taxid:8355(Xenopus laevis)	-	2015/11/23	2015/11/23	rogid:aOr+GNSM52kchmieeS16ZnQT5MM10116	rogid:A1/XuCa48PaklR0agTX87dVmyTE10116	rigid:fa8vIMiSrbsqlsb845KMWPHO7e0	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P37089	uniprotkb:P37091	intact:EBI-11422003|uniprotkb:Q64593|uniprotkb:Q9QUI4	intact:EBI-11422068	psi-mi:scnna_rat(display_long)|uniprotkb:Scnn1a(gene name)|psi-mi:Scnn1a(display_short)|uniprotkb:Renac(gene name synonym)|uniprotkb:Alpha-NaCH(gene name synonym)|uniprotkb:"Epithelial Na(+) channel subunit alpha"(gene name synonym)|uniprotkb:Nonvoltage-gated sodium channel 1 subunit alpha(gene name synonym)|uniprotkb:SCNEA(gene name synonym)	psi-mi:scnng_rat(display_long)|uniprotkb:Scnn1g(gene name)|psi-mi:Scnn1g(display_short)|uniprotkb:"Epithelial Na(+) channel subunit gamma"(gene name synonym)|uniprotkb:Gamma-NaCH(gene name synonym)|uniprotkb:Nonvoltage-gated sodium channel 1 subunit gamma(gene name synonym)|uniprotkb:SCNEG(gene name synonym)	psi-mi:"MI:0071"(molecular sieving)	Dijkink et al. (2002)	pubmed:12136275|imex:IM-24733	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0469"(IntAct)	intact:EBI-11422098|imex:IM-24733-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:3639|refseq:NP_113736.1|reactome:R-RNO-2672351|go:"GO:0055078"(sodium ion homeostasis)|go:"GO:0060170"(ciliary membrane)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097228"(sperm principal piece)|go:"GO:0098797"(plasma membrane protein complex)|go:"GO:1904045"(cellular response to aldosterone)|interpro:IPR001873(Na+ channel, amiloride-sensitive)|interpro:IPR004724(Epithelial sodium channel)|interpro:IPR020903|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006814"(sodium ion transport)|go:"GO:0008217"(regulation of blood pressure)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0015280"(ligand-gated sodium channel activity)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030864"(cortical actin cytoskeleton)|go:"GO:0031514"(motile cilium)|go:"GO:0034706"(sodium channel complex)|go:"GO:0035725"(sodium ion transmembrane transport)|go:"GO:0050699"(WW domain binding)|go:"GO:0003779"(actin binding)|go:"GO:0050878"(regulation of body fluid levels)|go:"GO:0050891"(multicellular organismal water homeostasis)|go:"GO:0050909"(sensory perception of taste)|dip:DIP-61308N	refseq:NP_058742.1|rgd:3641|reactome:R-RNO-2672351|go:"GO:0005216"(ion channel activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006814"(sodium ion transport)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0015280"(ligand-gated sodium channel activity)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0034706"(sodium channel complex)|go:"GO:0035313"(wound healing, spreading of epidermal cells)|go:"GO:0035725"(sodium ion transmembrane transport)|go:"GO:0050699"(WW domain binding)|go:"GO:0050891"(multicellular organismal water homeostasis)|go:"GO:0050909"(sensory perception of taste)|go:"GO:0055078"(sodium ion homeostasis)|go:"GO:0001666"(response to hypoxia)|go:"GO:0098797"(plasma membrane protein complex)|go:"GO:0070062"(extracellular exosome)|go:"GO:1904045"(cellular response to aldosterone)|interpro:IPR001873(Na+ channel, amiloride-sensitive)|interpro:IPR004724(Epithelial sodium channel)|interpro:IPR020903|dip:DIP-61327N	-	-	-	figure legend:Fig.s 1 & 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:8355(xenla-oocyte)|taxid:8355(Xenopus laevis)	-	2015/11/23	2015/11/23	rogid:aOr+GNSM52kchmieeS16ZnQT5MM10116	rogid:wb7e4GCC3aQvSwp9ZhesBaMo4ak10116	rigid:fa8vIMiSrbsqlsb845KMWPHO7e0	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)