#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
intact:EBI-10952519	uniprotkb:Q14765	-	intact:EBI-1186538|uniprotkb:Q96NZ6|ensembl:ENSP00000351255|ensembl:ENSP00000376134	psi-mi:stat_probe(display_short)|psi-mi:EBI-10952519(display_long)	psi-mi:stat4_human(display_long)|uniprotkb:STAT4(gene name)|psi-mi:STAT4(display_short)	psi-mi:"MI:0412"(electrophoretic mobility supershift assay)	Parham et al. (2002)	imex:IM-24780|pubmed:12023369	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10953216|imex:IM-24780-8	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0319"(deoxyribonucleic acid)	psi-mi:"MI:0326"(protein)	-	refseq:NP_003142.1|refseq:XP_006712782.1|refseq:NP_001230764.1|refseq:XP_011510007.1|ensembl:ENSG00000138378(gene)|ensembl:ENST00000358470(transcript)|ensembl:ENST00000392320(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006952"(defense response)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|interpro:IPR000980(SH2 motif)|interpro:IPR001217(STAT transcription factor, core)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR012345(STAT transcription factor, DNA-binding, subdomain)|interpro:IPR013799(STAT transcription factor, protein interaction)|interpro:IPR013800(STAT transcription factor, all-alpha)|interpro:IPR013801(STAT transcription factor, DNA-binding)|interpro:IPR015988(STAT transcription factor, coiled coil)|interpro:IPR029839|interpro:IPR035856|interpro:IPR036535|interpro:IPR036860|mint:Q14765|reactome:R-HSA-8854691|reactome:R-HSA-8950505|reactome:R-HSA-8984722|reactome:R-HSA-9020591|reactome:R-HSA-9020933|reactome:R-HSA-9020958|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|dip:DIP-39854N	-	-	-	figure legend:Fig. 7A lanes 2 and 3|agonist:"IL-12 (P29460)"|dataset:IBD - Inflammatory bowel disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-kit 225)|taxid:9606(Homo sapiens)	-	2015/07/15	2015/08/04	-	rogid:z6Wvolbix1XQBOsVA/MIxXi56qU9606	-	false	32p radiolabel:?-?	-	-	-	psi-mi:"MI:0866"(tag visualisation)	psi-mi:"MI:0866"(tag visualisation)
uniprotkb:P40763	intact:EBI-10952519	intact:EBI-518675|uniprotkb:O14916|uniprotkb:Q9BW54|ensembl:ENSP00000264657|ensembl:ENSP00000467985|ensembl:ENSP00000503102|ensembl:ENSP00000503181|ensembl:ENSP00000504184|uniprotkb:A8K7B8|uniprotkb:K7ENL3	-	psi-mi:stat3_human(display_long)|uniprotkb:Acute-phase response factor(gene name synonym)|uniprotkb:STAT3(gene name)|psi-mi:STAT3(display_short)|uniprotkb:APRF(gene name synonym)	psi-mi:stat_probe(display_short)|psi-mi:EBI-10952519(display_long)	psi-mi:"MI:0412"(electrophoretic mobility supershift assay)	Parham et al. (2002)	imex:IM-24780|pubmed:12023369	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10953278|imex:IM-24780-9	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0319"(deoxyribonucleic acid)	ensembl:ENSG00000168610(gene)|ensembl:ENST00000264657(transcript)|ensembl:ENST00000588969(transcript)|ensembl:ENST00000678044(transcript)|ensembl:ENST00000678906(transcript)|ensembl:ENST00000678960(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001659"(temperature homeostasis)|go:"GO:0001754"(eye photoreceptor cell differentiation)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0004879"(nuclear receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005829"(cytosol)|go:"GO:0010730"(negative regulation of hydrogen peroxide biosynthetic process)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016310"(phosphorylation)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019953"(sexual reproduction)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030522"(intracellular receptor signaling pathway)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0031730"(CCR5 chemokine receptor binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006952"(defense response)|go:"GO:0006953"(acute-phase response)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0007399"(nervous system development)|go:"GO:0007568"(aging)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0032355"(response to estradiol)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032870"(cellular response to hormone stimulus)|go:"GO:0033210"(leptin-mediated signaling pathway)|go:"GO:0035259"(glucocorticoid receptor binding)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042493"|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042755"(eating behavior)|go:"GO:0042789"(mRNA transcription by RNA polymerase II)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0044320"(cellular response to leptin stimulus)|go:"GO:0044321"(response to leptin)|go:"GO:0045471"(response to ethanol)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045747"(positive regulation of Notch signaling pathway)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046902"(regulation of mitochondrial membrane permeability)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048708"(astrocyte differentiation)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060019"(radial glial cell differentiation)|go:"GO:0060259"(regulation of feeding behavior)|go:"GO:0060396"(growth hormone receptor signaling pathway)|go:"GO:0060397"(growth hormone receptor signaling pathway via JAK-STAT)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070102"(interleukin-6-mediated signaling pathway)|go:"GO:0070878"(primary miRNA binding)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0072538"(T-helper 17 type immune response)|go:"GO:0072540"(T-helper 17 cell lineage commitment)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:0097009"(energy homeostasis)|reactome:R-HSA-8875791|reactome:R-HSA-8983432|reactome:R-HSA-8984722|reactome:R-HSA-8985947|reactome:R-HSA-9008059|reactome:R-HSA-9020933|reactome:R-HSA-9020956|reactome:R-HSA-9020958|reactome:R-HSA-9616222|reactome:R-HSA-9670439|reactome:R-HSA-9673767|reactome:R-HSA-9673770|reactome:R-HSA-9674555|reactome:R-HSA-9705462|reactome:R-HSA-9707564|reactome:R-HSA-982772|mint:P40763|rcsb pdb:5AX3|rcsb pdb:5U5S|rcsb pdb:6NJS|rcsb pdb:6NUQ|rcsb pdb:6QHD|rcsb pdb:6TLC|reactome:R-HSA-1059683|reactome:R-HSA-111453|reactome:R-HSA-1266695|reactome:R-HSA-1433557|reactome:R-HSA-1839117|reactome:R-HSA-186763|reactome:R-HSA-198745|reactome:R-HSA-2559582|reactome:R-HSA-2586552|reactome:R-HSA-2892247|reactome:R-HSA-390471|reactome:R-HSA-452723|reactome:R-HSA-6783783|reactome:R-HSA-6785807|reactome:R-HSA-8849474|reactome:R-HSA-8854691|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099527"(postsynapse to nucleus signaling pathway)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902728"(positive regulation of growth factor dependent skeletal muscle satellite cell proliferation)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1904685"(positive regulation of metalloendopeptidase activity)|go:"GO:1905564"(positive regulation of vascular endothelial cell proliferation)|go:"GO:1905618"(positive regulation of miRNA-mediated gene silencing by inhibition of translation)|go:"GO:2000635"(negative regulation of primary miRNA processing)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2000737"(negative regulation of stem cell differentiation)|go:"GO:2001171"(positive regulation of ATP biosynthetic process)|go:"GO:2001223"(negative regulation of neuron migration)|interpro:IPR000980(SH2 motif)|interpro:IPR001217(STAT transcription factor, core)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR012345(STAT transcription factor, DNA-binding, subdomain)|interpro:IPR013799(STAT transcription factor, protein interaction)|interpro:IPR013800(STAT transcription factor, all-alpha)|interpro:IPR013801(STAT transcription factor, DNA-binding)|interpro:IPR015988(STAT transcription factor, coiled coil)|interpro:IPR035855|interpro:IPR036535|interpro:IPR036860|refseq:NP_003141.2|refseq:NP_644805.1|refseq:NP_998827.1|refseq:XP_011523447.1|refseq:XP_011523448.1|refseq:XP_005257673.2|refseq:XP_005257674.2|refseq:XP_016880461.1|refseq:XP_016880464.1|dip:DIP-33584N	-	-	crc64:6C00632211C8012D	-	figure legend:Fig 7A, lanes 4,6,7,9|agonist:"IL-23 (Q9NPF7)"|dataset:IBD - Inflammatory bowel disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-kit 225)|taxid:9606(Homo sapiens)	-	2015/07/15	2015/08/03	rogid:MEbOYO8fRKMGF0zejkJIzR6jACQ9606	-	-	false	-	32p radiolabel:?-?	-	-	psi-mi:"MI:0866"(tag visualisation)	psi-mi:"MI:0866"(tag visualisation)
intact:EBI-10952519	uniprotkb:P40763	-	intact:EBI-518675|uniprotkb:O14916|uniprotkb:Q9BW54|ensembl:ENSP00000264657|ensembl:ENSP00000467985|ensembl:ENSP00000503102|ensembl:ENSP00000503181|ensembl:ENSP00000504184|uniprotkb:A8K7B8|uniprotkb:K7ENL3	psi-mi:stat_probe(display_short)|psi-mi:EBI-10952519(display_long)	psi-mi:stat3_human(display_long)|uniprotkb:Acute-phase response factor(gene name synonym)|uniprotkb:STAT3(gene name)|psi-mi:STAT3(display_short)|uniprotkb:APRF(gene name synonym)	psi-mi:"MI:0412"(electrophoretic mobility supershift assay)	Parham et al. (2002)	imex:IM-24780|pubmed:12023369	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10953680|imex:IM-24780-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0319"(deoxyribonucleic acid)	psi-mi:"MI:0326"(protein)	-	ensembl:ENSG00000168610(gene)|ensembl:ENST00000264657(transcript)|ensembl:ENST00000588969(transcript)|ensembl:ENST00000678044(transcript)|ensembl:ENST00000678906(transcript)|ensembl:ENST00000678960(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001659"(temperature homeostasis)|go:"GO:0001754"(eye photoreceptor cell differentiation)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0004879"(nuclear receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005829"(cytosol)|go:"GO:0010730"(negative regulation of hydrogen peroxide biosynthetic process)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016310"(phosphorylation)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019953"(sexual reproduction)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030522"(intracellular receptor signaling pathway)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0031730"(CCR5 chemokine receptor binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006952"(defense response)|go:"GO:0006953"(acute-phase response)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0007399"(nervous system development)|go:"GO:0007568"(aging)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0032355"(response to estradiol)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032870"(cellular response to hormone stimulus)|go:"GO:0033210"(leptin-mediated signaling pathway)|go:"GO:0035259"(glucocorticoid receptor binding)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042493"|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042755"(eating behavior)|go:"GO:0042789"(mRNA transcription by RNA polymerase II)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0044320"(cellular response to leptin stimulus)|go:"GO:0044321"(response to leptin)|go:"GO:0045471"(response to ethanol)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045747"(positive regulation of Notch signaling pathway)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046902"(regulation of mitochondrial membrane permeability)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048708"(astrocyte differentiation)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060019"(radial glial cell differentiation)|go:"GO:0060259"(regulation of feeding behavior)|go:"GO:0060396"(growth hormone receptor signaling pathway)|go:"GO:0060397"(growth hormone receptor signaling pathway via JAK-STAT)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070102"(interleukin-6-mediated signaling pathway)|go:"GO:0070878"(primary miRNA binding)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0072538"(T-helper 17 type immune response)|go:"GO:0072540"(T-helper 17 cell lineage commitment)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:0097009"(energy homeostasis)|reactome:R-HSA-8875791|reactome:R-HSA-8983432|reactome:R-HSA-8984722|reactome:R-HSA-8985947|reactome:R-HSA-9008059|reactome:R-HSA-9020933|reactome:R-HSA-9020956|reactome:R-HSA-9020958|reactome:R-HSA-9616222|reactome:R-HSA-9670439|reactome:R-HSA-9673767|reactome:R-HSA-9673770|reactome:R-HSA-9674555|reactome:R-HSA-9705462|reactome:R-HSA-9707564|reactome:R-HSA-982772|mint:P40763|rcsb pdb:5AX3|rcsb pdb:5U5S|rcsb pdb:6NJS|rcsb pdb:6NUQ|rcsb pdb:6QHD|rcsb pdb:6TLC|reactome:R-HSA-1059683|reactome:R-HSA-111453|reactome:R-HSA-1266695|reactome:R-HSA-1433557|reactome:R-HSA-1839117|reactome:R-HSA-186763|reactome:R-HSA-198745|reactome:R-HSA-2559582|reactome:R-HSA-2586552|reactome:R-HSA-2892247|reactome:R-HSA-390471|reactome:R-HSA-452723|reactome:R-HSA-6783783|reactome:R-HSA-6785807|reactome:R-HSA-8849474|reactome:R-HSA-8854691|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099527"(postsynapse to nucleus signaling pathway)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902728"(positive regulation of growth factor dependent skeletal muscle satellite cell proliferation)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1904685"(positive regulation of metalloendopeptidase activity)|go:"GO:1905564"(positive regulation of vascular endothelial cell proliferation)|go:"GO:1905618"(positive regulation of miRNA-mediated gene silencing by inhibition of translation)|go:"GO:2000635"(negative regulation of primary miRNA processing)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2000737"(negative regulation of stem cell differentiation)|go:"GO:2001171"(positive regulation of ATP biosynthetic process)|go:"GO:2001223"(negative regulation of neuron migration)|interpro:IPR000980(SH2 motif)|interpro:IPR001217(STAT transcription factor, core)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR012345(STAT transcription factor, DNA-binding, subdomain)|interpro:IPR013799(STAT transcription factor, protein interaction)|interpro:IPR013800(STAT transcription factor, all-alpha)|interpro:IPR013801(STAT transcription factor, DNA-binding)|interpro:IPR015988(STAT transcription factor, coiled coil)|interpro:IPR035855|interpro:IPR036535|interpro:IPR036860|refseq:NP_003141.2|refseq:NP_644805.1|refseq:NP_998827.1|refseq:XP_011523447.1|refseq:XP_011523448.1|refseq:XP_005257673.2|refseq:XP_005257674.2|refseq:XP_016880461.1|refseq:XP_016880464.1|dip:DIP-33584N	-	-	crc64:6C00632211C8012D	figure legend:Fig. 7A lanes 4,7|agonist:"IL23 (Q9NPF7)"|dataset:IBD - Inflammatory bowel disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-kit 225)|taxid:9606(Homo sapiens)	-	2015/07/15	2015/08/04	-	rogid:MEbOYO8fRKMGF0zejkJIzR6jACQ9606	-	false	32p radiolabel:?-?	-	-	-	psi-mi:"MI:0866"(tag visualisation)	psi-mi:"MI:0866"(tag visualisation)
intact:EBI-10952519	uniprotkb:Q14765	-	intact:EBI-1186538|uniprotkb:Q96NZ6|ensembl:ENSP00000351255|ensembl:ENSP00000376134	psi-mi:stat_probe(display_short)|psi-mi:EBI-10952519(display_long)	psi-mi:stat4_human(display_long)|uniprotkb:STAT4(gene name)|psi-mi:STAT4(display_short)	psi-mi:"MI:0412"(electrophoretic mobility supershift assay)	Parham et al. (2002)	imex:IM-24780|pubmed:12023369	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10953680|imex:IM-24780-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0319"(deoxyribonucleic acid)	psi-mi:"MI:0326"(protein)	-	refseq:NP_003142.1|refseq:XP_006712782.1|refseq:NP_001230764.1|refseq:XP_011510007.1|ensembl:ENSG00000138378(gene)|ensembl:ENST00000358470(transcript)|ensembl:ENST00000392320(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006952"(defense response)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|interpro:IPR000980(SH2 motif)|interpro:IPR001217(STAT transcription factor, core)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR012345(STAT transcription factor, DNA-binding, subdomain)|interpro:IPR013799(STAT transcription factor, protein interaction)|interpro:IPR013800(STAT transcription factor, all-alpha)|interpro:IPR013801(STAT transcription factor, DNA-binding)|interpro:IPR015988(STAT transcription factor, coiled coil)|interpro:IPR029839|interpro:IPR035856|interpro:IPR036535|interpro:IPR036860|mint:Q14765|reactome:R-HSA-8854691|reactome:R-HSA-8950505|reactome:R-HSA-8984722|reactome:R-HSA-9020591|reactome:R-HSA-9020933|reactome:R-HSA-9020958|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|dip:DIP-39854N	-	-	-	figure legend:Fig. 7A lanes 4,7|agonist:"IL23 (Q9NPF7)"|dataset:IBD - Inflammatory bowel disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-kit 225)|taxid:9606(Homo sapiens)	-	2015/07/15	2015/08/04	-	rogid:z6Wvolbix1XQBOsVA/MIxXi56qU9606	-	false	32p radiolabel:?-?	-	-	-	psi-mi:"MI:0866"(tag visualisation)	psi-mi:"MI:0866"(tag visualisation)
intact:EBI-10952519	uniprotkb:P42224	-	intact:EBI-1057697|uniprotkb:Q53S88|uniprotkb:Q53XW4|uniprotkb:B2RCA0|uniprotkb:Q9UDL5|uniprotkb:A8K989|uniprotkb:D2KFR8|uniprotkb:Q68D00|uniprotkb:D3DPI7|ensembl:ENSP00000354394|ensembl:ENSP00000386244|ensembl:ENSP00000388240|ensembl:ENSP00000438703	psi-mi:stat_probe(display_short)|psi-mi:EBI-10952519(display_long)	psi-mi:stat1_human(display_long)|uniprotkb:STAT1(gene name)|psi-mi:STAT1(display_short)|uniprotkb:Transcription factor ISGF-3 components p91/p84(gene name synonym)	psi-mi:"MI:0412"(electrophoretic mobility supershift assay)	Parham et al. (2002)	imex:IM-24780|pubmed:12023369	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10953690|imex:IM-24780-10	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0319"(deoxyribonucleic acid)	psi-mi:"MI:0326"(protein)	-	refseq:NP_009330.1|refseq:NP_644671.1|rcsb pdb:1YVL|rcsb pdb:2KA6|rcsb pdb:3WWT|reactome:R-HSA-1059683|reactome:R-HSA-1169408|reactome:R-HSA-1433557|reactome:R-HSA-1839117|reactome:R-HSA-186763|reactome:R-HSA-6785807|reactome:R-HSA-877300|reactome:R-HSA-877312|reactome:R-HSA-8854691|reactome:R-HSA-8939902|reactome:R-HSA-8984722|reactome:R-HSA-8985947|reactome:R-HSA-9013508|reactome:R-HSA-9020956|reactome:R-HSA-9020958|reactome:R-HSA-909733|rcsb pdb:1BF5|reactome:R-HSA-9670439|reactome:R-HSA-9673767|reactome:R-HSA-9673770|reactome:R-HSA-9674555|reactome:R-HSA-9705462|reactome:R-HSA-982772|reactome:R-HSA-912694|refseq:XP_006712781.1|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006952"(defense response)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0007584"(response to nutrient)|go:"GO:0008015"(blood circulation)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0010742"(macrophage derived foam cell differentiation)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0016922"(nuclear receptor binding)|ensembl:ENSG00000115415(gene)|ensembl:ENST00000361099(transcript)|ensembl:ENST00000409465(transcript)|ensembl:ENST00000415035(transcript)|ensembl:ENST00000540176(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000979"(RNA polymerase II core promoter sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0002053"(positive regulation of mesenchymal cell proliferation)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0003340"(negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0042493"|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0044389"(ubiquitin-like protein ligase binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0072162"(metanephric mesenchymal cell differentiation)|go:"GO:0072308"(negative regulation of metanephric nephron tubule epithelial cell differentiation)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000980(SH2 motif)|interpro:IPR001217(STAT transcription factor, core)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|go:"GO:0046725"(negative regulation by virus of viral protein levels in host cell)|interpro:IPR012345(STAT transcription factor, DNA-binding, subdomain)|interpro:IPR013799(STAT transcription factor, protein interaction)|interpro:IPR013800(STAT transcription factor, all-alpha)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0051591"(response to cAMP)|go:"GO:0051607"(defense response to virus)|go:"GO:0051721"(protein phosphatase 2A binding)|go:"GO:0051770"(positive regulation of nitric-oxide synthase biosynthetic process)|go:"GO:0060333"(interferon-gamma-mediated signaling pathway)|go:"GO:0060337"(type I interferon signaling pathway)|go:"GO:0061326"(renal tubule development)|go:"GO:0070106"(interleukin-27-mediated signaling pathway)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071407"(cellular response to organic cyclic compound)|interpro:IPR013801(STAT transcription factor, DNA-binding)|interpro:IPR015988(STAT transcription factor, coiled coil)|interpro:IPR022752|go:"GO:0072136"(metanephric mesenchymal cell proliferation involved in metanephros development)|interpro:IPR035859|interpro:IPR036535|interpro:IPR036860|interpro:IPR038295|mint:P42224|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019899"(enzyme binding)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031730"(CCR5 chemokine receptor binding)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034097"(response to cytokine)|go:"GO:0035035"(histone acetyltransferase binding)|go:"GO:0035456"(response to interferon-beta)|go:"GO:0035458"(cellular response to interferon-beta)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042393"(histone binding)|dip:DIP-46140N	-	-	-	figure legend:Fig. 7A, lanes 4,8,9,10|agonist:"IL23 (Q9NPF7)"|dataset:IBD - Inflammatory bowel disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-kit 225)|taxid:9606(Homo sapiens)	-	2015/07/15	2015/08/04	-	rogid:a2ZnhdFZkctbjaXLpsYNJ3q5Cv49606	-	false	32p radiolabel:?-?	-	-	-	psi-mi:"MI:0866"(tag visualisation)	psi-mi:"MI:0866"(tag visualisation)
uniprotkb:Q9NPF7	uniprotkb:Q5VWK5	intact:EBI-2481154|ensembl:ENSP00000228534|uniprotkb:Q6NZ80|uniprotkb:Q6NZ82|uniprotkb:Q9H2A5	intact:EBI-10248005|uniprotkb:Q8NFQ9|uniprotkb:Q96AS1|uniprotkb:Q4VGP3|uniprotkb:Q8IW84|uniprotkb:Q4VGP5|uniprotkb:Q4VGP6|uniprotkb:Q4VGP2|uniprotkb:Q5VWK7|uniprotkb:Q4VGP1|uniprotkb:Q4VGP4|uniprotkb:C9JGX4|ensembl:ENSP00000321345	psi-mi:il23a_human(display_long)|uniprotkb:IL23A(gene name)|psi-mi:IL23A(display_short)|uniprotkb:SGRF(gene name synonym)|uniprotkb:Interleukin-23 subunit p19(gene name synonym)|uniprotkb:UNQ2498/PRO5798(orf name)	psi-mi:il23r_human(display_long)|uniprotkb:IL23R(gene name)|psi-mi:IL23R(display_short)	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)	Parham et al. (2002)	imex:IM-24780|pubmed:12023369	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10903444|imex:IM-24780-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000110944(gene)|ensembl:ENST00000228534(transcript)|go:"GO:0001916"(positive regulation of T cell mediated cytotoxicity)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0002827"(positive regulation of T-helper 1 type immune response)|go:"GO:0005125"(cytokine activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0043382"(positive regulation of memory T cell differentiation)|go:"GO:0045087"(innate immune response)|go:"GO:0045672"(positive regulation of osteoclast differentiation)|go:"GO:0048771"(tissue remodeling)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0051135"(positive regulation of NK T cell activation)|go:"GO:0051142"(positive regulation of NK T cell proliferation)|go:"GO:0051607"(defense response to virus)|go:"GO:0070743"(interleukin-23 complex)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:2000318"(positive regulation of T-helper 17 type immune response)|go:"GO:2000330"(positive regulation of T-helper 17 cell lineage commitment)|interpro:IPR009079(Four-helical cytokine-like, core)|interpro:IPR010831(Interleukin 23 alpha subunit p19)|rcsb pdb:3D85|go:"GO:0010536"(positive regulation of activation of Janus kinase activity)|go:"GO:0032693"(negative regulation of interleukin-10 production)|go:"GO:0032725"(positive regulation of granulocyte macrophage colony-stimulating factor production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032740"(positive regulation of interleukin-17 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032816"(positive regulation of natural killer cell activation)|go:"GO:0032819"(positive regulation of natural killer cell proliferation)|go:"GO:0034105"(positive regulation of tissue remodeling)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042104"(positive regulation of activated T cell proliferation)|go:"GO:0042509"(regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0006954"(inflammatory response)|rcsb pdb:3DUH|rcsb pdb:3QWR|rcsb pdb:4GRW|rcsb pdb:5MJ3|rcsb pdb:5MJ4|rcsb pdb:5MXA|rcsb pdb:5MZV|rcsb pdb:5NJD|rcsb pdb:6UIB|rcsb pdb:6WDQ|reactome:R-HSA-6785807|reactome:R-HSA-9020933|rcsb pdb:3D87|refseq:XP_011536779.1|refseq:NP_057668.1	refseq:NP_653302.2|refseq:XP_005270573.1|refseq:XP_011539092.1|refseq:XP_011539093.1|ensembl:ENSG00000162594(gene)|ensembl:ENST00000347310(transcript)|go:"GO:0001916"(positive regulation of T cell mediated cytotoxicity)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0002827"(positive regulation of T-helper 1 type immune response)|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010536"(positive regulation of activation of Janus kinase activity)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019955"(cytokine binding)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032693"(negative regulation of interleukin-10 production)|go:"GO:0032725"(positive regulation of granulocyte macrophage colony-stimulating factor production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032740"(positive regulation of interleukin-17 production)|go:"GO:0032819"(positive regulation of natural killer cell proliferation)|go:"GO:0034341"(response to interferon-gamma)|go:"GO:0038155"(interleukin-23-mediated signaling pathway)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042104"(positive regulation of activated T cell proliferation)|go:"GO:0042509"(regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0043235"(receptor complex)|go:"GO:0043382"(positive regulation of memory T cell differentiation)|go:"GO:0045672"(positive regulation of osteoclast differentiation)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0051135"(positive regulation of NK T cell activation)|go:"GO:0072536"(interleukin-23 receptor complex)|go:"GO:2000318"(positive regulation of T-helper 17 type immune response)|go:"GO:2000330"(positive regulation of T-helper 17 cell lineage commitment)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036116|rcsb pdb:5MZV|rcsb pdb:6WDQ|reactome:R-HSA-6785807|reactome:R-HSA-9020933	-	-	-	figure legend:Fig 4B|causality statement:Q9NPF7 activates Q5VWK5|dataset:IBD - Inflammatory bowel disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2015/07/15	2020/02/14	rogid:cGuBTF6IoaUFDF7jhyLoNrfYvXg9606	rogid:j3Kjewnfoxv3Dvie81Sh0xkasn89606	rigid:UDbc1IgASv2eGPnTIlTM0hmkAAA	false	flag tag:n-n	fc-igg tag:?-?|sufficient binding region:24..24-355..355	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:P29460	uniprotkb:Q9NPF7	intact:EBI-1029614|ensembl:ENSP00000231228	intact:EBI-2481154|ensembl:ENSP00000228534|uniprotkb:Q6NZ80|uniprotkb:Q6NZ82|uniprotkb:Q9H2A5	psi-mi:il12b_human(display_long)|uniprotkb:IL12B(gene name)|psi-mi:IL12B(display_short)|uniprotkb:NKSF2(gene name synonym)|uniprotkb:IL-12 subunit p40(gene name synonym)|uniprotkb:Cytotoxic lymphocyte maturation factor 40 kDa subunit(gene name synonym)|uniprotkb:NK cell stimulatory factor chain 2(gene name synonym)	psi-mi:il23a_human(display_long)|uniprotkb:IL23A(gene name)|psi-mi:IL23A(display_short)|uniprotkb:SGRF(gene name synonym)|uniprotkb:Interleukin-23 subunit p19(gene name synonym)|uniprotkb:UNQ2498/PRO5798(orf name)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Parham et al. (2002)	imex:IM-24780|pubmed:12023369	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10904098|imex:IM-24780-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002178.2|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042104"(positive regulation of activated T cell proliferation)|go:"GO:0042164"(interleukin-12 alpha subunit binding)|go:"GO:0042509"(regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042802"(identical protein binding)|go:"GO:0042832"(defense response to protozoan)|go:"GO:0043235"(receptor complex)|go:"GO:0043382"(positive regulation of memory T cell differentiation)|go:"GO:0043514"(interleukin-12 complex)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045672"(positive regulation of osteoclast differentiation)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:0050671"(positive regulation of lymphocyte proliferation)|ensembl:ENSG00000113302(gene)|ensembl:ENST00000231228(transcript)|go:"GO:0001817"(regulation of cytokine production)|go:"GO:0001916"(positive regulation of T cell mediated cytotoxicity)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0002827"(positive regulation of T-helper 1 type immune response)|go:"GO:0002860"(positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target)|go:"GO:0002862"(negative regulation of inflammatory response to antigenic stimulus)|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0005125"(cytokine activity)|go:"GO:0005143"(interleukin-12 receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0002323"(natural killer cell activation involved in immune response)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005829"(cytosol)|go:"GO:0008283"(cell population proliferation)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010224"(response to UV-B)|go:"GO:0010536"(positive regulation of activation of Janus kinase activity)|go:"GO:0016477"(cell migration)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019953"(sexual reproduction)|go:"GO:0019955"(cytokine binding)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0030101"(natural killer cell activation)|go:"GO:0031906"(late endosome lumen)|go:"GO:0032693"(negative regulation of interleukin-10 production)|go:"GO:0032700"(negative regulation of interleukin-17 production)|go:"GO:0032725"(positive regulation of granulocyte macrophage colony-stimulating factor production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032740"(positive regulation of interleukin-17 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032816"(positive regulation of natural killer cell activation)|go:"GO:0032819"(positive regulation of natural killer cell proliferation)|go:"GO:0032946"(positive regulation of mononuclear cell proliferation)|go:"GO:0034105"(positive regulation of tissue remodeling)|go:"GO:0034393"(positive regulation of smooth muscle cell apoptotic process)|go:"GO:0042088"(T-helper 1 type immune response)|go:"GO:0042093"(T-helper cell differentiation)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0051135"(positive regulation of NK T cell activation)|go:"GO:0051142"(positive regulation of NK T cell proliferation)|go:"GO:0051607"(defense response to virus)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070743"(interleukin-23 complex)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:1900747"(negative regulation of vascular endothelial growth factor signaling pathway)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1903588"(negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis)|go:"GO:2000318"(positive regulation of T-helper 17 type immune response)|go:"GO:0050709"(negative regulation of protein secretion)|go:"GO:2000330"(positive regulation of T-helper 17 cell lineage commitment)|interpro:IPR003530(Long hematopoietin receptor, soluble alpha chain, conserved site)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR015528(Interleukin-12 beta chain)|interpro:IPR019482|interpro:IPR036116|interpro:IPR036179|rcsb pdb:1F42|rcsb pdb:1F45|rcsb pdb:3D85|rcsb pdb:3D87|interpro:IPR013783(Immunoglobulin-like fold)|rcsb pdb:3DUH|rcsb pdb:3HMX|rcsb pdb:3QWR|rcsb pdb:4GRW|rcsb pdb:5MJ3|rcsb pdb:5MJ4|rcsb pdb:5MXA|rcsb pdb:5MZV|rcsb pdb:5NJD|rcsb pdb:6UIB|rcsb pdb:6WDQ|reactome:R-HSA-6783783|reactome:R-HSA-6785807|reactome:R-HSA-9020591|reactome:R-HSA-9020933|dip:DIP-3774N	ensembl:ENSG00000110944(gene)|ensembl:ENST00000228534(transcript)|go:"GO:0001916"(positive regulation of T cell mediated cytotoxicity)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0002827"(positive regulation of T-helper 1 type immune response)|go:"GO:0005125"(cytokine activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0043382"(positive regulation of memory T cell differentiation)|go:"GO:0045087"(innate immune response)|go:"GO:0045672"(positive regulation of osteoclast differentiation)|go:"GO:0048771"(tissue remodeling)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0051135"(positive regulation of NK T cell activation)|go:"GO:0051142"(positive regulation of NK T cell proliferation)|go:"GO:0051607"(defense response to virus)|go:"GO:0070743"(interleukin-23 complex)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:2000318"(positive regulation of T-helper 17 type immune response)|go:"GO:2000330"(positive regulation of T-helper 17 cell lineage commitment)|interpro:IPR009079(Four-helical cytokine-like, core)|interpro:IPR010831(Interleukin 23 alpha subunit p19)|rcsb pdb:3D85|go:"GO:0010536"(positive regulation of activation of Janus kinase activity)|go:"GO:0032693"(negative regulation of interleukin-10 production)|go:"GO:0032725"(positive regulation of granulocyte macrophage colony-stimulating factor production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032740"(positive regulation of interleukin-17 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032816"(positive regulation of natural killer cell activation)|go:"GO:0032819"(positive regulation of natural killer cell proliferation)|go:"GO:0034105"(positive regulation of tissue remodeling)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042104"(positive regulation of activated T cell proliferation)|go:"GO:0042509"(regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0006954"(inflammatory response)|rcsb pdb:3DUH|rcsb pdb:3QWR|rcsb pdb:4GRW|rcsb pdb:5MJ3|rcsb pdb:5MJ4|rcsb pdb:5MXA|rcsb pdb:5MZV|rcsb pdb:5NJD|rcsb pdb:6UIB|rcsb pdb:6WDQ|reactome:R-HSA-6785807|reactome:R-HSA-9020933|rcsb pdb:3D87|refseq:XP_011536779.1|refseq:NP_057668.1	-	-	-	figure legend:Fig. 4C|dataset:IBD - Inflammatory bowel disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-ba_f3)|taxid:10090(Mouse pro B cells IL-3 dependent)	-	2015/07/15	2015/11/26	rogid:090ptpS0BAD5BZT079b8oOTHmCg9606	rogid:cGuBTF6IoaUFDF7jhyLoNrfYvXg9606	rigid:jJIVwLBI7jn7ZCvFiLOhjYJMa8k	false	flag tag:n-n	flag tag:n-n	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P29460	uniprotkb:Q5VWK5	intact:EBI-1029614|ensembl:ENSP00000231228	intact:EBI-10248005|uniprotkb:Q8NFQ9|uniprotkb:Q96AS1|uniprotkb:Q4VGP3|uniprotkb:Q8IW84|uniprotkb:Q4VGP5|uniprotkb:Q4VGP6|uniprotkb:Q4VGP2|uniprotkb:Q5VWK7|uniprotkb:Q4VGP1|uniprotkb:Q4VGP4|uniprotkb:C9JGX4|ensembl:ENSP00000321345	psi-mi:il12b_human(display_long)|uniprotkb:IL12B(gene name)|psi-mi:IL12B(display_short)|uniprotkb:NKSF2(gene name synonym)|uniprotkb:IL-12 subunit p40(gene name synonym)|uniprotkb:Cytotoxic lymphocyte maturation factor 40 kDa subunit(gene name synonym)|uniprotkb:NK cell stimulatory factor chain 2(gene name synonym)	psi-mi:il23r_human(display_long)|uniprotkb:IL23R(gene name)|psi-mi:IL23R(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Parham et al. (2002)	imex:IM-24780|pubmed:12023369	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10904098|imex:IM-24780-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002178.2|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042104"(positive regulation of activated T cell proliferation)|go:"GO:0042164"(interleukin-12 alpha subunit binding)|go:"GO:0042509"(regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042802"(identical protein binding)|go:"GO:0042832"(defense response to protozoan)|go:"GO:0043235"(receptor complex)|go:"GO:0043382"(positive regulation of memory T cell differentiation)|go:"GO:0043514"(interleukin-12 complex)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045672"(positive regulation of osteoclast differentiation)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:0050671"(positive regulation of lymphocyte proliferation)|ensembl:ENSG00000113302(gene)|ensembl:ENST00000231228(transcript)|go:"GO:0001817"(regulation of cytokine production)|go:"GO:0001916"(positive regulation of T cell mediated cytotoxicity)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0002827"(positive regulation of T-helper 1 type immune response)|go:"GO:0002860"(positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target)|go:"GO:0002862"(negative regulation of inflammatory response to antigenic stimulus)|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0005125"(cytokine activity)|go:"GO:0005143"(interleukin-12 receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0002323"(natural killer cell activation involved in immune response)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005829"(cytosol)|go:"GO:0008283"(cell population proliferation)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010224"(response to UV-B)|go:"GO:0010536"(positive regulation of activation of Janus kinase activity)|go:"GO:0016477"(cell migration)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019953"(sexual reproduction)|go:"GO:0019955"(cytokine binding)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0030101"(natural killer cell activation)|go:"GO:0031906"(late endosome lumen)|go:"GO:0032693"(negative regulation of interleukin-10 production)|go:"GO:0032700"(negative regulation of interleukin-17 production)|go:"GO:0032725"(positive regulation of granulocyte macrophage colony-stimulating factor production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032740"(positive regulation of interleukin-17 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032816"(positive regulation of natural killer cell activation)|go:"GO:0032819"(positive regulation of natural killer cell proliferation)|go:"GO:0032946"(positive regulation of mononuclear cell proliferation)|go:"GO:0034105"(positive regulation of tissue remodeling)|go:"GO:0034393"(positive regulation of smooth muscle cell apoptotic process)|go:"GO:0042088"(T-helper 1 type immune response)|go:"GO:0042093"(T-helper cell differentiation)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0051135"(positive regulation of NK T cell activation)|go:"GO:0051142"(positive regulation of NK T cell proliferation)|go:"GO:0051607"(defense response to virus)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070743"(interleukin-23 complex)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:1900747"(negative regulation of vascular endothelial growth factor signaling pathway)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1903588"(negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis)|go:"GO:2000318"(positive regulation of T-helper 17 type immune response)|go:"GO:0050709"(negative regulation of protein secretion)|go:"GO:2000330"(positive regulation of T-helper 17 cell lineage commitment)|interpro:IPR003530(Long hematopoietin receptor, soluble alpha chain, conserved site)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR015528(Interleukin-12 beta chain)|interpro:IPR019482|interpro:IPR036116|interpro:IPR036179|rcsb pdb:1F42|rcsb pdb:1F45|rcsb pdb:3D85|rcsb pdb:3D87|interpro:IPR013783(Immunoglobulin-like fold)|rcsb pdb:3DUH|rcsb pdb:3HMX|rcsb pdb:3QWR|rcsb pdb:4GRW|rcsb pdb:5MJ3|rcsb pdb:5MJ4|rcsb pdb:5MXA|rcsb pdb:5MZV|rcsb pdb:5NJD|rcsb pdb:6UIB|rcsb pdb:6WDQ|reactome:R-HSA-6783783|reactome:R-HSA-6785807|reactome:R-HSA-9020591|reactome:R-HSA-9020933|dip:DIP-3774N	refseq:NP_653302.2|refseq:XP_005270573.1|refseq:XP_011539092.1|refseq:XP_011539093.1|ensembl:ENSG00000162594(gene)|ensembl:ENST00000347310(transcript)|go:"GO:0001916"(positive regulation of T cell mediated cytotoxicity)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0002827"(positive regulation of T-helper 1 type immune response)|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010536"(positive regulation of activation of Janus kinase activity)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019955"(cytokine binding)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032693"(negative regulation of interleukin-10 production)|go:"GO:0032725"(positive regulation of granulocyte macrophage colony-stimulating factor production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032740"(positive regulation of interleukin-17 production)|go:"GO:0032819"(positive regulation of natural killer cell proliferation)|go:"GO:0034341"(response to interferon-gamma)|go:"GO:0038155"(interleukin-23-mediated signaling pathway)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042104"(positive regulation of activated T cell proliferation)|go:"GO:0042509"(regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0043235"(receptor complex)|go:"GO:0043382"(positive regulation of memory T cell differentiation)|go:"GO:0045672"(positive regulation of osteoclast differentiation)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0051135"(positive regulation of NK T cell activation)|go:"GO:0072536"(interleukin-23 receptor complex)|go:"GO:2000318"(positive regulation of T-helper 17 type immune response)|go:"GO:2000330"(positive regulation of T-helper 17 cell lineage commitment)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036116|rcsb pdb:5MZV|rcsb pdb:6WDQ|reactome:R-HSA-6785807|reactome:R-HSA-9020933	-	-	-	figure legend:Fig. 4C|dataset:IBD - Inflammatory bowel disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-ba_f3)|taxid:10090(Mouse pro B cells IL-3 dependent)	-	2015/07/15	2015/11/26	rogid:090ptpS0BAD5BZT079b8oOTHmCg9606	rogid:j3Kjewnfoxv3Dvie81Sh0xkasn89606	rigid:jJIVwLBI7jn7ZCvFiLOhjYJMa8k	false	flag tag:n-n	his tag:c-c|sufficient binding region:24..24-355..355|v5 tag:c-c	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
intact:EBI-10952519	uniprotkb:P40763	-	intact:EBI-518675|uniprotkb:O14916|uniprotkb:Q9BW54|ensembl:ENSP00000264657|ensembl:ENSP00000467985|ensembl:ENSP00000503102|ensembl:ENSP00000503181|ensembl:ENSP00000504184|uniprotkb:A8K7B8|uniprotkb:K7ENL3	psi-mi:stat_probe(display_short)|psi-mi:EBI-10952519(display_long)	psi-mi:stat3_human(display_long)|uniprotkb:Acute-phase response factor(gene name synonym)|uniprotkb:STAT3(gene name)|psi-mi:STAT3(display_short)|uniprotkb:APRF(gene name synonym)	psi-mi:"MI:0412"(electrophoretic mobility supershift assay)	Parham et al. (2002)	imex:IM-24780|pubmed:12023369	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10953986|imex:IM-24780-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0319"(deoxyribonucleic acid)	psi-mi:"MI:0326"(protein)	-	ensembl:ENSG00000168610(gene)|ensembl:ENST00000264657(transcript)|ensembl:ENST00000588969(transcript)|ensembl:ENST00000678044(transcript)|ensembl:ENST00000678906(transcript)|ensembl:ENST00000678960(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001659"(temperature homeostasis)|go:"GO:0001754"(eye photoreceptor cell differentiation)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0004879"(nuclear receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005829"(cytosol)|go:"GO:0010730"(negative regulation of hydrogen peroxide biosynthetic process)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016310"(phosphorylation)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019953"(sexual reproduction)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030522"(intracellular receptor signaling pathway)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0031730"(CCR5 chemokine receptor binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006952"(defense response)|go:"GO:0006953"(acute-phase response)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0007399"(nervous system development)|go:"GO:0007568"(aging)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0032355"(response to estradiol)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032870"(cellular response to hormone stimulus)|go:"GO:0033210"(leptin-mediated signaling pathway)|go:"GO:0035259"(glucocorticoid receptor binding)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042493"|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042755"(eating behavior)|go:"GO:0042789"(mRNA transcription by RNA polymerase II)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0044320"(cellular response to leptin stimulus)|go:"GO:0044321"(response to leptin)|go:"GO:0045471"(response to ethanol)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045747"(positive regulation of Notch signaling pathway)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046902"(regulation of mitochondrial membrane permeability)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048708"(astrocyte differentiation)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060019"(radial glial cell differentiation)|go:"GO:0060259"(regulation of feeding behavior)|go:"GO:0060396"(growth hormone receptor signaling pathway)|go:"GO:0060397"(growth hormone receptor signaling pathway via JAK-STAT)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070102"(interleukin-6-mediated signaling pathway)|go:"GO:0070878"(primary miRNA binding)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0072538"(T-helper 17 type immune response)|go:"GO:0072540"(T-helper 17 cell lineage commitment)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:0097009"(energy homeostasis)|reactome:R-HSA-8875791|reactome:R-HSA-8983432|reactome:R-HSA-8984722|reactome:R-HSA-8985947|reactome:R-HSA-9008059|reactome:R-HSA-9020933|reactome:R-HSA-9020956|reactome:R-HSA-9020958|reactome:R-HSA-9616222|reactome:R-HSA-9670439|reactome:R-HSA-9673767|reactome:R-HSA-9673770|reactome:R-HSA-9674555|reactome:R-HSA-9705462|reactome:R-HSA-9707564|reactome:R-HSA-982772|mint:P40763|rcsb pdb:5AX3|rcsb pdb:5U5S|rcsb pdb:6NJS|rcsb pdb:6NUQ|rcsb pdb:6QHD|rcsb pdb:6TLC|reactome:R-HSA-1059683|reactome:R-HSA-111453|reactome:R-HSA-1266695|reactome:R-HSA-1433557|reactome:R-HSA-1839117|reactome:R-HSA-186763|reactome:R-HSA-198745|reactome:R-HSA-2559582|reactome:R-HSA-2586552|reactome:R-HSA-2892247|reactome:R-HSA-390471|reactome:R-HSA-452723|reactome:R-HSA-6783783|reactome:R-HSA-6785807|reactome:R-HSA-8849474|reactome:R-HSA-8854691|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099527"(postsynapse to nucleus signaling pathway)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902728"(positive regulation of growth factor dependent skeletal muscle satellite cell proliferation)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1904685"(positive regulation of metalloendopeptidase activity)|go:"GO:1905564"(positive regulation of vascular endothelial cell proliferation)|go:"GO:1905618"(positive regulation of miRNA-mediated gene silencing by inhibition of translation)|go:"GO:2000635"(negative regulation of primary miRNA processing)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2000737"(negative regulation of stem cell differentiation)|go:"GO:2001171"(positive regulation of ATP biosynthetic process)|go:"GO:2001223"(negative regulation of neuron migration)|interpro:IPR000980(SH2 motif)|interpro:IPR001217(STAT transcription factor, core)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR012345(STAT transcription factor, DNA-binding, subdomain)|interpro:IPR013799(STAT transcription factor, protein interaction)|interpro:IPR013800(STAT transcription factor, all-alpha)|interpro:IPR013801(STAT transcription factor, DNA-binding)|interpro:IPR015988(STAT transcription factor, coiled coil)|interpro:IPR035855|interpro:IPR036535|interpro:IPR036860|refseq:NP_003141.2|refseq:NP_644805.1|refseq:NP_998827.1|refseq:XP_011523447.1|refseq:XP_011523448.1|refseq:XP_005257673.2|refseq:XP_005257674.2|refseq:XP_016880461.1|refseq:XP_016880464.1|dip:DIP-33584N	-	-	crc64:6C00632211C8012D	figure legend:Fig. 7B lanes 4,8|agonist:"IL23 (Q9NPF7) is an agonist"|dataset:IBD - Inflammatory bowel disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-t-cell)|taxid:9606(Homo sapiens)	-	2015/07/15	2015/08/04	-	rogid:MEbOYO8fRKMGF0zejkJIzR6jACQ9606	-	false	32p radiolabel:?-?	-	-	-	psi-mi:"MI:0866"(tag visualisation)	psi-mi:"MI:0866"(tag visualisation)
intact:EBI-10952519	uniprotkb:Q14765	-	intact:EBI-1186538|uniprotkb:Q96NZ6|ensembl:ENSP00000351255|ensembl:ENSP00000376134	psi-mi:stat_probe(display_short)|psi-mi:EBI-10952519(display_long)	psi-mi:stat4_human(display_long)|uniprotkb:STAT4(gene name)|psi-mi:STAT4(display_short)	psi-mi:"MI:0412"(electrophoretic mobility supershift assay)	Parham et al. (2002)	imex:IM-24780|pubmed:12023369	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10953986|imex:IM-24780-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0319"(deoxyribonucleic acid)	psi-mi:"MI:0326"(protein)	-	refseq:NP_003142.1|refseq:XP_006712782.1|refseq:NP_001230764.1|refseq:XP_011510007.1|ensembl:ENSG00000138378(gene)|ensembl:ENST00000358470(transcript)|ensembl:ENST00000392320(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006952"(defense response)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|interpro:IPR000980(SH2 motif)|interpro:IPR001217(STAT transcription factor, core)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR012345(STAT transcription factor, DNA-binding, subdomain)|interpro:IPR013799(STAT transcription factor, protein interaction)|interpro:IPR013800(STAT transcription factor, all-alpha)|interpro:IPR013801(STAT transcription factor, DNA-binding)|interpro:IPR015988(STAT transcription factor, coiled coil)|interpro:IPR029839|interpro:IPR035856|interpro:IPR036535|interpro:IPR036860|mint:Q14765|reactome:R-HSA-8854691|reactome:R-HSA-8950505|reactome:R-HSA-8984722|reactome:R-HSA-9020591|reactome:R-HSA-9020933|reactome:R-HSA-9020958|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|dip:DIP-39854N	-	-	-	figure legend:Fig. 7B lanes 4,8|agonist:"IL23 (Q9NPF7) is an agonist"|dataset:IBD - Inflammatory bowel disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-t-cell)|taxid:9606(Homo sapiens)	-	2015/07/15	2015/08/04	-	rogid:z6Wvolbix1XQBOsVA/MIxXi56qU9606	-	false	32p radiolabel:?-?	-	-	-	psi-mi:"MI:0866"(tag visualisation)	psi-mi:"MI:0866"(tag visualisation)
uniprotkb:P40763	intact:EBI-10952519	intact:EBI-518675|uniprotkb:O14916|uniprotkb:Q9BW54|ensembl:ENSP00000264657|ensembl:ENSP00000467985|ensembl:ENSP00000503102|ensembl:ENSP00000503181|ensembl:ENSP00000504184|uniprotkb:A8K7B8|uniprotkb:K7ENL3	-	psi-mi:stat3_human(display_long)|uniprotkb:Acute-phase response factor(gene name synonym)|uniprotkb:STAT3(gene name)|psi-mi:STAT3(display_short)|uniprotkb:APRF(gene name synonym)	psi-mi:stat_probe(display_short)|psi-mi:EBI-10952519(display_long)	psi-mi:"MI:0412"(electrophoretic mobility supershift assay)	Parham et al. (2002)	imex:IM-24780|pubmed:12023369	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10953980|imex:IM-24780-11	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0319"(deoxyribonucleic acid)	ensembl:ENSG00000168610(gene)|ensembl:ENST00000264657(transcript)|ensembl:ENST00000588969(transcript)|ensembl:ENST00000678044(transcript)|ensembl:ENST00000678906(transcript)|ensembl:ENST00000678960(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001659"(temperature homeostasis)|go:"GO:0001754"(eye photoreceptor cell differentiation)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0004879"(nuclear receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005829"(cytosol)|go:"GO:0010730"(negative regulation of hydrogen peroxide biosynthetic process)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016310"(phosphorylation)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019953"(sexual reproduction)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030522"(intracellular receptor signaling pathway)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0031730"(CCR5 chemokine receptor binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006952"(defense response)|go:"GO:0006953"(acute-phase response)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0007399"(nervous system development)|go:"GO:0007568"(aging)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0032355"(response to estradiol)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032870"(cellular response to hormone stimulus)|go:"GO:0033210"(leptin-mediated signaling pathway)|go:"GO:0035259"(glucocorticoid receptor binding)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042493"|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042755"(eating behavior)|go:"GO:0042789"(mRNA transcription by RNA polymerase II)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0044320"(cellular response to leptin stimulus)|go:"GO:0044321"(response to leptin)|go:"GO:0045471"(response to ethanol)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045747"(positive regulation of Notch signaling pathway)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046902"(regulation of mitochondrial membrane permeability)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048708"(astrocyte differentiation)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060019"(radial glial cell differentiation)|go:"GO:0060259"(regulation of feeding behavior)|go:"GO:0060396"(growth hormone receptor signaling pathway)|go:"GO:0060397"(growth hormone receptor signaling pathway via JAK-STAT)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070102"(interleukin-6-mediated signaling pathway)|go:"GO:0070878"(primary miRNA binding)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0072538"(T-helper 17 type immune response)|go:"GO:0072540"(T-helper 17 cell lineage commitment)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:0097009"(energy homeostasis)|reactome:R-HSA-8875791|reactome:R-HSA-8983432|reactome:R-HSA-8984722|reactome:R-HSA-8985947|reactome:R-HSA-9008059|reactome:R-HSA-9020933|reactome:R-HSA-9020956|reactome:R-HSA-9020958|reactome:R-HSA-9616222|reactome:R-HSA-9670439|reactome:R-HSA-9673767|reactome:R-HSA-9673770|reactome:R-HSA-9674555|reactome:R-HSA-9705462|reactome:R-HSA-9707564|reactome:R-HSA-982772|mint:P40763|rcsb pdb:5AX3|rcsb pdb:5U5S|rcsb pdb:6NJS|rcsb pdb:6NUQ|rcsb pdb:6QHD|rcsb pdb:6TLC|reactome:R-HSA-1059683|reactome:R-HSA-111453|reactome:R-HSA-1266695|reactome:R-HSA-1433557|reactome:R-HSA-1839117|reactome:R-HSA-186763|reactome:R-HSA-198745|reactome:R-HSA-2559582|reactome:R-HSA-2586552|reactome:R-HSA-2892247|reactome:R-HSA-390471|reactome:R-HSA-452723|reactome:R-HSA-6783783|reactome:R-HSA-6785807|reactome:R-HSA-8849474|reactome:R-HSA-8854691|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099527"(postsynapse to nucleus signaling pathway)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902728"(positive regulation of growth factor dependent skeletal muscle satellite cell proliferation)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1904685"(positive regulation of metalloendopeptidase activity)|go:"GO:1905564"(positive regulation of vascular endothelial cell proliferation)|go:"GO:1905618"(positive regulation of miRNA-mediated gene silencing by inhibition of translation)|go:"GO:2000635"(negative regulation of primary miRNA processing)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2000737"(negative regulation of stem cell differentiation)|go:"GO:2001171"(positive regulation of ATP biosynthetic process)|go:"GO:2001223"(negative regulation of neuron migration)|interpro:IPR000980(SH2 motif)|interpro:IPR001217(STAT transcription factor, core)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR012345(STAT transcription factor, DNA-binding, subdomain)|interpro:IPR013799(STAT transcription factor, protein interaction)|interpro:IPR013800(STAT transcription factor, all-alpha)|interpro:IPR013801(STAT transcription factor, DNA-binding)|interpro:IPR015988(STAT transcription factor, coiled coil)|interpro:IPR035855|interpro:IPR036535|interpro:IPR036860|refseq:NP_003141.2|refseq:NP_644805.1|refseq:NP_998827.1|refseq:XP_011523447.1|refseq:XP_011523448.1|refseq:XP_005257673.2|refseq:XP_005257674.2|refseq:XP_016880461.1|refseq:XP_016880464.1|dip:DIP-33584N	-	-	crc64:6C00632211C8012D	-	figure legend:Fig 7B, lanes 4,6,8|agonist:"IL23 (Q9NPF7) is an agonist for STAT3 activation."|dataset:IBD - Inflammatory bowel disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-t-cell)|taxid:9606(Homo sapiens)	-	2015/07/15	2015/08/04	rogid:MEbOYO8fRKMGF0zejkJIzR6jACQ9606	-	-	false	-	32p radiolabel:?-?	-	-	psi-mi:"MI:0866"(tag visualisation)	psi-mi:"MI:0866"(tag visualisation)
intact:EBI-10952519	uniprotkb:Q14765	-	intact:EBI-1186538|uniprotkb:Q96NZ6|ensembl:ENSP00000351255|ensembl:ENSP00000376134	psi-mi:stat_probe(display_short)|psi-mi:EBI-10952519(display_long)	psi-mi:stat4_human(display_long)|uniprotkb:STAT4(gene name)|psi-mi:STAT4(display_short)	psi-mi:"MI:0412"(electrophoretic mobility supershift assay)	Parham et al. (2002)	imex:IM-24780|pubmed:12023369	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10953993|imex:IM-24780-12	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0319"(deoxyribonucleic acid)	psi-mi:"MI:0326"(protein)	-	refseq:NP_003142.1|refseq:XP_006712782.1|refseq:NP_001230764.1|refseq:XP_011510007.1|ensembl:ENSG00000138378(gene)|ensembl:ENST00000358470(transcript)|ensembl:ENST00000392320(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006952"(defense response)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|interpro:IPR000980(SH2 motif)|interpro:IPR001217(STAT transcription factor, core)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR012345(STAT transcription factor, DNA-binding, subdomain)|interpro:IPR013799(STAT transcription factor, protein interaction)|interpro:IPR013800(STAT transcription factor, all-alpha)|interpro:IPR013801(STAT transcription factor, DNA-binding)|interpro:IPR015988(STAT transcription factor, coiled coil)|interpro:IPR029839|interpro:IPR035856|interpro:IPR036535|interpro:IPR036860|mint:Q14765|reactome:R-HSA-8854691|reactome:R-HSA-8950505|reactome:R-HSA-8984722|reactome:R-HSA-9020591|reactome:R-HSA-9020933|reactome:R-HSA-9020958|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|dip:DIP-39854N	-	-	-	figure legend:Fig. 7B lanes 2,3|agonist:IL12 is agonist for STAT4 activation.|dataset:IBD - Inflammatory bowel disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-t-cell)|taxid:9606(Homo sapiens)	-	2015/07/15	2015/11/09	-	rogid:z6Wvolbix1XQBOsVA/MIxXi56qU9606	-	false	32p radiolabel:?-?	-	-	-	psi-mi:"MI:0866"(tag visualisation)	psi-mi:"MI:0866"(tag visualisation)
intact:EBI-10952519	uniprotkb:Q14765	-	intact:EBI-1186538|uniprotkb:Q96NZ6|ensembl:ENSP00000351255|ensembl:ENSP00000376134	psi-mi:stat_probe(display_short)|psi-mi:EBI-10952519(display_long)	psi-mi:stat4_human(display_long)|uniprotkb:STAT4(gene name)|psi-mi:STAT4(display_short)	psi-mi:"MI:0412"(electrophoretic mobility supershift assay)	Parham et al. (2002)	imex:IM-24780|pubmed:12023369	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10954006|imex:IM-24780-13	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0319"(deoxyribonucleic acid)	psi-mi:"MI:0326"(protein)	-	refseq:NP_003142.1|refseq:XP_006712782.1|refseq:NP_001230764.1|refseq:XP_011510007.1|ensembl:ENSG00000138378(gene)|ensembl:ENST00000358470(transcript)|ensembl:ENST00000392320(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006952"(defense response)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|interpro:IPR000980(SH2 motif)|interpro:IPR001217(STAT transcription factor, core)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR012345(STAT transcription factor, DNA-binding, subdomain)|interpro:IPR013799(STAT transcription factor, protein interaction)|interpro:IPR013800(STAT transcription factor, all-alpha)|interpro:IPR013801(STAT transcription factor, DNA-binding)|interpro:IPR015988(STAT transcription factor, coiled coil)|interpro:IPR029839|interpro:IPR035856|interpro:IPR036535|interpro:IPR036860|mint:Q14765|reactome:R-HSA-8854691|reactome:R-HSA-8950505|reactome:R-HSA-8984722|reactome:R-HSA-9020591|reactome:R-HSA-9020933|reactome:R-HSA-9020958|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|dip:DIP-39854N	-	-	-	figure legend:Fig. 7B lanes 4,7,8|agonist:"IL23 (Q9NPF7) is an agonist"|dataset:IBD - Inflammatory bowel disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-t-cell)|taxid:9606(Homo sapiens)	-	2015/07/15	2015/08/04	-	rogid:z6Wvolbix1XQBOsVA/MIxXi56qU9606	-	false	32p radiolabel:?-?	-	-	-	psi-mi:"MI:0866"(tag visualisation)	psi-mi:"MI:0866"(tag visualisation)
uniprotkb:P42701	uniprotkb:Q9NPF7	intact:EBI-2481251|ensembl:ENSP00000470788|ensembl:ENSP00000472165|uniprotkb:A8K308|uniprotkb:B2RPF1|uniprotkb:B7ZKK3|uniprotkb:Q8N6Q7	intact:EBI-2481154|ensembl:ENSP00000228534|uniprotkb:Q6NZ80|uniprotkb:Q6NZ82|uniprotkb:Q9H2A5	psi-mi:i12r1_human(display_long)|uniprotkb:IL12RB1(gene name)|psi-mi:IL12RB1(display_short)|uniprotkb:IL12R(gene name synonym)|uniprotkb:IL12RB(gene name synonym)|uniprotkb:IL-12 receptor beta component(gene name synonym)	psi-mi:il23a_human(display_long)|uniprotkb:IL23A(gene name)|psi-mi:IL23A(display_short)|uniprotkb:SGRF(gene name synonym)|uniprotkb:Interleukin-23 subunit p19(gene name synonym)|uniprotkb:UNQ2498/PRO5798(orf name)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Parham et al. (2002)	imex:IM-24780|pubmed:12023369	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10954020|imex:IM-24780-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000096996(gene)|ensembl:ENST00000593993(transcript)|ensembl:ENST00000600835(transcript)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0002827"(positive regulation of T-helper 1 type immune response)|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019955"(cytokine binding)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0035722"(interleukin-12-mediated signaling pathway)|go:"GO:0038155"(interleukin-23-mediated signaling pathway)|go:"GO:0042022"(interleukin-12 receptor complex)|go:"GO:0042104"(positive regulation of activated T cell proliferation)|go:"GO:0043235"(receptor complex)|go:"GO:0043382"(positive regulation of memory T cell differentiation)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0001916"(positive regulation of T cell mediated cytotoxicity)|go:"GO:2000318"(positive regulation of T-helper 17 type immune response)|go:"GO:2000330"(positive regulation of T-helper 17 cell lineage commitment)|interpro:IPR003529(Long hematopoietin receptor, gp130 family 2, conserved site)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036116|rcsb pdb:6WDP|rcsb pdb:6WDQ|reactome:R-HSA-9020591|reactome:R-HSA-9020933|go:"GO:0072536"(interleukin-23 receptor complex)|refseq:NP_005526.1|refseq:NP_714912.1|refseq:NP_001276952.1|dip:DIP-3773N	ensembl:ENSG00000110944(gene)|ensembl:ENST00000228534(transcript)|go:"GO:0001916"(positive regulation of T cell mediated cytotoxicity)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0002827"(positive regulation of T-helper 1 type immune response)|go:"GO:0005125"(cytokine activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0043382"(positive regulation of memory T cell differentiation)|go:"GO:0045087"(innate immune response)|go:"GO:0045672"(positive regulation of osteoclast differentiation)|go:"GO:0048771"(tissue remodeling)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0051135"(positive regulation of NK T cell activation)|go:"GO:0051142"(positive regulation of NK T cell proliferation)|go:"GO:0051607"(defense response to virus)|go:"GO:0070743"(interleukin-23 complex)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:2000318"(positive regulation of T-helper 17 type immune response)|go:"GO:2000330"(positive regulation of T-helper 17 cell lineage commitment)|interpro:IPR009079(Four-helical cytokine-like, core)|interpro:IPR010831(Interleukin 23 alpha subunit p19)|rcsb pdb:3D85|go:"GO:0010536"(positive regulation of activation of Janus kinase activity)|go:"GO:0032693"(negative regulation of interleukin-10 production)|go:"GO:0032725"(positive regulation of granulocyte macrophage colony-stimulating factor production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032740"(positive regulation of interleukin-17 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032816"(positive regulation of natural killer cell activation)|go:"GO:0032819"(positive regulation of natural killer cell proliferation)|go:"GO:0034105"(positive regulation of tissue remodeling)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042104"(positive regulation of activated T cell proliferation)|go:"GO:0042509"(regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0006954"(inflammatory response)|rcsb pdb:3DUH|rcsb pdb:3QWR|rcsb pdb:4GRW|rcsb pdb:5MJ3|rcsb pdb:5MJ4|rcsb pdb:5MXA|rcsb pdb:5MZV|rcsb pdb:5NJD|rcsb pdb:6UIB|rcsb pdb:6WDQ|reactome:R-HSA-6785807|reactome:R-HSA-9020933|rcsb pdb:3D87|refseq:XP_011536779.1|refseq:NP_057668.1	-	-	comment:agonist	figure legend:Fig. 7C lane 6|agonist:"IL-23 (Q9NPF7)  is agonist of IL12B (P29460) activation"|dataset:IBD - Inflammatory bowel disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-kit 225)|taxid:9606(Homo sapiens)	-	2015/07/15	2015/11/08	rogid:i+z7ptusYAIgGyvLrRce6Dmp5q89606	rogid:cGuBTF6IoaUFDF7jhyLoNrfYvXg9606	rigid:hkk3PexiRdVm5mPyA3xVmDGbQjA	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P42701	uniprotkb:Q5VWK5	intact:EBI-2481251|ensembl:ENSP00000470788|ensembl:ENSP00000472165|uniprotkb:A8K308|uniprotkb:B2RPF1|uniprotkb:B7ZKK3|uniprotkb:Q8N6Q7	intact:EBI-10248005|uniprotkb:Q8NFQ9|uniprotkb:Q96AS1|uniprotkb:Q4VGP3|uniprotkb:Q8IW84|uniprotkb:Q4VGP5|uniprotkb:Q4VGP6|uniprotkb:Q4VGP2|uniprotkb:Q5VWK7|uniprotkb:Q4VGP1|uniprotkb:Q4VGP4|uniprotkb:C9JGX4|ensembl:ENSP00000321345	psi-mi:i12r1_human(display_long)|uniprotkb:IL12RB1(gene name)|psi-mi:IL12RB1(display_short)|uniprotkb:IL12R(gene name synonym)|uniprotkb:IL12RB(gene name synonym)|uniprotkb:IL-12 receptor beta component(gene name synonym)	psi-mi:il23r_human(display_long)|uniprotkb:IL23R(gene name)|psi-mi:IL23R(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Parham et al. (2002)	imex:IM-24780|pubmed:12023369	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10954020|imex:IM-24780-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000096996(gene)|ensembl:ENST00000593993(transcript)|ensembl:ENST00000600835(transcript)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0002827"(positive regulation of T-helper 1 type immune response)|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019955"(cytokine binding)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0035722"(interleukin-12-mediated signaling pathway)|go:"GO:0038155"(interleukin-23-mediated signaling pathway)|go:"GO:0042022"(interleukin-12 receptor complex)|go:"GO:0042104"(positive regulation of activated T cell proliferation)|go:"GO:0043235"(receptor complex)|go:"GO:0043382"(positive regulation of memory T cell differentiation)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0001916"(positive regulation of T cell mediated cytotoxicity)|go:"GO:2000318"(positive regulation of T-helper 17 type immune response)|go:"GO:2000330"(positive regulation of T-helper 17 cell lineage commitment)|interpro:IPR003529(Long hematopoietin receptor, gp130 family 2, conserved site)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036116|rcsb pdb:6WDP|rcsb pdb:6WDQ|reactome:R-HSA-9020591|reactome:R-HSA-9020933|go:"GO:0072536"(interleukin-23 receptor complex)|refseq:NP_005526.1|refseq:NP_714912.1|refseq:NP_001276952.1|dip:DIP-3773N	refseq:NP_653302.2|refseq:XP_005270573.1|refseq:XP_011539092.1|refseq:XP_011539093.1|ensembl:ENSG00000162594(gene)|ensembl:ENST00000347310(transcript)|go:"GO:0001916"(positive regulation of T cell mediated cytotoxicity)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0002827"(positive regulation of T-helper 1 type immune response)|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010536"(positive regulation of activation of Janus kinase activity)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019955"(cytokine binding)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032693"(negative regulation of interleukin-10 production)|go:"GO:0032725"(positive regulation of granulocyte macrophage colony-stimulating factor production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032740"(positive regulation of interleukin-17 production)|go:"GO:0032819"(positive regulation of natural killer cell proliferation)|go:"GO:0034341"(response to interferon-gamma)|go:"GO:0038155"(interleukin-23-mediated signaling pathway)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042104"(positive regulation of activated T cell proliferation)|go:"GO:0042509"(regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0043235"(receptor complex)|go:"GO:0043382"(positive regulation of memory T cell differentiation)|go:"GO:0045672"(positive regulation of osteoclast differentiation)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0051135"(positive regulation of NK T cell activation)|go:"GO:0072536"(interleukin-23 receptor complex)|go:"GO:2000318"(positive regulation of T-helper 17 type immune response)|go:"GO:2000330"(positive regulation of T-helper 17 cell lineage commitment)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036116|rcsb pdb:5MZV|rcsb pdb:6WDQ|reactome:R-HSA-6785807|reactome:R-HSA-9020933	-	-	-	figure legend:Fig. 7C lane 6|agonist:"IL-23 (Q9NPF7)  is agonist of IL12B (P29460) activation"|dataset:IBD - Inflammatory bowel disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-kit 225)|taxid:9606(Homo sapiens)	-	2015/07/15	2015/11/08	rogid:i+z7ptusYAIgGyvLrRce6Dmp5q89606	rogid:j3Kjewnfoxv3Dvie81Sh0xkasn89606	rigid:hkk3PexiRdVm5mPyA3xVmDGbQjA	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q5VWK5	uniprotkb:Q62120	intact:EBI-10248005|uniprotkb:Q8NFQ9|uniprotkb:Q96AS1|uniprotkb:Q4VGP3|uniprotkb:Q8IW84|uniprotkb:Q4VGP5|uniprotkb:Q4VGP6|uniprotkb:Q4VGP2|uniprotkb:Q5VWK7|uniprotkb:Q4VGP1|uniprotkb:Q4VGP4|uniprotkb:C9JGX4|ensembl:ENSP00000321345	intact:EBI-646604|uniprotkb:Q7TQD0|uniprotkb:Q62124|intact:EBI-16039126|ensembl:ENSMUSP00000025705|ensembl:ENSMUSP00000064394|ensembl:ENSMUSP00000158242|uniprotkb:G5E852	psi-mi:il23r_human(display_long)|uniprotkb:IL23R(gene name)|psi-mi:IL23R(display_short)	psi-mi:jak2_mouse(display_long)|uniprotkb:Janus kinase 2(gene name synonym)|uniprotkb:Jak2(gene name)|psi-mi:Jak2(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Parham et al. (2002)	imex:IM-24780|pubmed:12023369	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10954038|imex:IM-24780-6	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_653302.2|refseq:XP_005270573.1|refseq:XP_011539092.1|refseq:XP_011539093.1|ensembl:ENSG00000162594(gene)|ensembl:ENST00000347310(transcript)|go:"GO:0001916"(positive regulation of T cell mediated cytotoxicity)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0002827"(positive regulation of T-helper 1 type immune response)|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010536"(positive regulation of activation of Janus kinase activity)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019955"(cytokine binding)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032693"(negative regulation of interleukin-10 production)|go:"GO:0032725"(positive regulation of granulocyte macrophage colony-stimulating factor production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032740"(positive regulation of interleukin-17 production)|go:"GO:0032819"(positive regulation of natural killer cell proliferation)|go:"GO:0034341"(response to interferon-gamma)|go:"GO:0038155"(interleukin-23-mediated signaling pathway)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042104"(positive regulation of activated T cell proliferation)|go:"GO:0042509"(regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0043235"(receptor complex)|go:"GO:0043382"(positive regulation of memory T cell differentiation)|go:"GO:0045672"(positive regulation of osteoclast differentiation)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0051135"(positive regulation of NK T cell activation)|go:"GO:0072536"(interleukin-23 receptor complex)|go:"GO:2000318"(positive regulation of T-helper 17 type immune response)|go:"GO:2000330"(positive regulation of T-helper 17 cell lineage commitment)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036116|rcsb pdb:5MZV|rcsb pdb:6WDQ|reactome:R-HSA-6785807|reactome:R-HSA-9020933	refseq:NP_001041642.1|refseq:NP_032439.2|dip:DIP-320N|ensembl:ENSMUSG00000024789(gene)|ensembl:ENSMUST00000025705(transcript)|ensembl:ENSMUST00000065796(transcript)|ensembl:ENSMUST00000238009(transcript)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0000791"(euchromatin)|go:"GO:0001774"(microglial cell activation)|go:"GO:0002250"(adaptive immune response)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0050867"(positive regulation of cell activation)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051428"(peptide hormone receptor binding)|go:"GO:0051770"(positive regulation of nitric-oxide synthase biosynthetic process)|go:"GO:0060333"(interferon-gamma-mediated signaling pathway)|go:"GO:0060391"(positive regulation of SMAD protein signal transduction)|go:"GO:0060396"(growth hormone receptor signaling pathway)|go:"GO:0060397"(growth hormone receptor signaling pathway via JAK-STAT)|go:"GO:0060399"(positive regulation of growth hormone receptor signaling pathway)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0061180"(mammary gland epithelium development)|go:"GO:0070671"(response to interleukin-12)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071549"(cellular response to dexamethasone stimulus)|go:"GO:0097012"(response to granulocyte macrophage colony-stimulating factor)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097296"(activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099527"(postsynapse to nucleus signaling pathway)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1902728"(positive regulation of growth factor dependent skeletal muscle satellite cell proliferation)|go:"GO:1904037"(positive regulation of epithelial cell apoptotic process)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:2000273"(positive regulation of signaling receptor activity)|go:"GO:2001235"(positive regulation of apoptotic signaling pathway)|interpro:IPR000299(Band 4.1, N-terminal)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR016251(Tyrosine-protein kinase, Jak/Tyk2)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|go:"GO:0098794"(postsynapse)|interpro:IPR019749|go:"GO:0022408"(negative regulation of cell-cell adhesion)|go:"GO:0030099"(myeloid cell differentiation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031103"(axon regeneration)|go:"GO:0031702"(type 1 angiotensin receptor binding)|go:"GO:0031959"(mineralocorticoid receptor signaling pathway)|go:"GO:0032024"(positive regulation of insulin secretion)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032516"(positive regulation of phosphoprotein phosphatase activity)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0033130"(acetylcholine receptor binding)|go:"GO:0033194"(response to hydroperoxide)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0020037"(heme binding)|interpro:IPR020693|interpro:IPR035588|interpro:IPR035589|interpro:IPR035860|interpro:IPR035963|interpro:IPR036860|interpro:IPR037838|interpro:IPR041046|interpro:IPR041155|interpro:IPR041381|mint:Q62120|rcsb pdb:2HDX|rcsb pdb:4GL9|reactome:R-MMU-1059683|reactome:R-MMU-110056|interpro:IPR020635|reactome:R-MMU-112411|reactome:R-MMU-1170546|go:"GO:0034612"(response to tumor necrosis factor)|go:"GO:0035166"(post-embryonic hemopoiesis)|go:"GO:0035401"("histone kinase activity (H3-Y41 specific)")|go:"GO:0035409"(histone H3-Y41 phosphorylation)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035722"(interleukin-12-mediated signaling pathway)|go:"GO:0036016"(cellular response to interleukin-3)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042393"(histone binding)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042802"(identical protein binding)|go:"GO:0042976"(activation of Janus kinase activity)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0034050"(programmed cell death induced by symbiont)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005131"(growth hormone receptor binding)|go:"GO:0005143"(interleukin-12 receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0007167"(enzyme linked receptor protein signaling pathway)|go:"GO:0005901"(caveola)|go:"GO:0005925"(focal adhesion)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007165"(signal transduction)|reactome:R-MMU-512988|reactome:R-MMU-5673000|reactome:R-MMU-5673001|reactome:R-MMU-6785807|reactome:R-MMU-6788467|reactome:R-MMU-69231|reactome:R-MMU-877300|reactome:R-MMU-877312|reactome:R-MMU-8854691|reactome:R-MMU-8984722|reactome:R-MMU-9020591|reactome:R-MMU-9020933|reactome:R-MMU-9020956|reactome:R-MMU-9027276|reactome:R-MMU-9027284|reactome:R-MMU-912526|reactome:R-MMU-9674555|reactome:R-MMU-9705462|reactome:R-MMU-982772|reactome:R-MMU-983231|reactome:R-MMU-1433557|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0007260"(tyrosine phosphorylation of STAT protein)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008631"(intrinsic apoptotic signaling pathway in response to oxidative stress)|go:"GO:0009755"(hormone-mediated signaling pathway)|go:"GO:0010667"(negative regulation of cardiac muscle cell apoptotic process)|go:"GO:0010811"(positive regulation of cell-substrate adhesion)|go:"GO:0012505"(endomembrane system)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019901"(protein kinase binding)|go:"GO:0043392"(negative regulation of DNA binding)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045348"(positive regulation of MHC class II biosynthetic process)|go:"GO:0045428"(regulation of nitric oxide biosynthetic process)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0045597"(positive regulation of cell differentiation)|go:"GO:0045822"(negative regulation of heart contraction)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046677"(response to antibiotic)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0048008"(platelet-derived growth factor receptor signaling pathway)|go:"GO:0043388"(positive regulation of DNA binding)|dip:DIP-60238N|refseq:XP_011245457.1	-	-	-	figure legend:Fig. 7D lanes 3 and 4|dataset:IBD - Inflammatory bowel disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-ba_f3)|taxid:10090(Mouse pro B cells IL-3 dependent)	-	2015/07/15	2021/02/11	rogid:j3Kjewnfoxv3Dvie81Sh0xkasn89606	rogid:pdjCNCHmNTiJ1gGtJyiWoGgtq4I10090	rigid:GJhsLJA5c5bFnZn+3GTZ/K3VrxU	false	myc tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q5VWK5	uniprotkb:Q62120	intact:EBI-10248005|uniprotkb:Q8NFQ9|uniprotkb:Q96AS1|uniprotkb:Q4VGP3|uniprotkb:Q8IW84|uniprotkb:Q4VGP5|uniprotkb:Q4VGP6|uniprotkb:Q4VGP2|uniprotkb:Q5VWK7|uniprotkb:Q4VGP1|uniprotkb:Q4VGP4|uniprotkb:C9JGX4|ensembl:ENSP00000321345	intact:EBI-646604|uniprotkb:Q7TQD0|uniprotkb:Q62124|intact:EBI-16039126|ensembl:ENSMUSP00000025705|ensembl:ENSMUSP00000064394|ensembl:ENSMUSP00000158242|uniprotkb:G5E852	psi-mi:il23r_human(display_long)|uniprotkb:IL23R(gene name)|psi-mi:IL23R(display_short)	psi-mi:jak2_mouse(display_long)|uniprotkb:Janus kinase 2(gene name synonym)|uniprotkb:Jak2(gene name)|psi-mi:Jak2(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Parham et al. (2002)	imex:IM-24780|pubmed:12023369	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10954052|imex:IM-24780-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_653302.2|refseq:XP_005270573.1|refseq:XP_011539092.1|refseq:XP_011539093.1|ensembl:ENSG00000162594(gene)|ensembl:ENST00000347310(transcript)|go:"GO:0001916"(positive regulation of T cell mediated cytotoxicity)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0002827"(positive regulation of T-helper 1 type immune response)|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010536"(positive regulation of activation of Janus kinase activity)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019955"(cytokine binding)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032693"(negative regulation of interleukin-10 production)|go:"GO:0032725"(positive regulation of granulocyte macrophage colony-stimulating factor production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032740"(positive regulation of interleukin-17 production)|go:"GO:0032819"(positive regulation of natural killer cell proliferation)|go:"GO:0034341"(response to interferon-gamma)|go:"GO:0038155"(interleukin-23-mediated signaling pathway)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042104"(positive regulation of activated T cell proliferation)|go:"GO:0042509"(regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0043235"(receptor complex)|go:"GO:0043382"(positive regulation of memory T cell differentiation)|go:"GO:0045672"(positive regulation of osteoclast differentiation)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0051135"(positive regulation of NK T cell activation)|go:"GO:0072536"(interleukin-23 receptor complex)|go:"GO:2000318"(positive regulation of T-helper 17 type immune response)|go:"GO:2000330"(positive regulation of T-helper 17 cell lineage commitment)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036116|rcsb pdb:5MZV|rcsb pdb:6WDQ|reactome:R-HSA-6785807|reactome:R-HSA-9020933	refseq:NP_001041642.1|refseq:NP_032439.2|dip:DIP-320N|ensembl:ENSMUSG00000024789(gene)|ensembl:ENSMUST00000025705(transcript)|ensembl:ENSMUST00000065796(transcript)|ensembl:ENSMUST00000238009(transcript)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0000791"(euchromatin)|go:"GO:0001774"(microglial cell activation)|go:"GO:0002250"(adaptive immune response)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0050867"(positive regulation of cell activation)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051428"(peptide hormone receptor binding)|go:"GO:0051770"(positive regulation of nitric-oxide synthase biosynthetic process)|go:"GO:0060333"(interferon-gamma-mediated signaling pathway)|go:"GO:0060391"(positive regulation of SMAD protein signal transduction)|go:"GO:0060396"(growth hormone receptor signaling pathway)|go:"GO:0060397"(growth hormone receptor signaling pathway via JAK-STAT)|go:"GO:0060399"(positive regulation of growth hormone receptor signaling pathway)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0061180"(mammary gland epithelium development)|go:"GO:0070671"(response to interleukin-12)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071549"(cellular response to dexamethasone stimulus)|go:"GO:0097012"(response to granulocyte macrophage colony-stimulating factor)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097296"(activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099527"(postsynapse to nucleus signaling pathway)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1902728"(positive regulation of growth factor dependent skeletal muscle satellite cell proliferation)|go:"GO:1904037"(positive regulation of epithelial cell apoptotic process)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:2000273"(positive regulation of signaling receptor activity)|go:"GO:2001235"(positive regulation of apoptotic signaling pathway)|interpro:IPR000299(Band 4.1, N-terminal)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR016251(Tyrosine-protein kinase, Jak/Tyk2)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|go:"GO:0098794"(postsynapse)|interpro:IPR019749|go:"GO:0022408"(negative regulation of cell-cell adhesion)|go:"GO:0030099"(myeloid cell differentiation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031103"(axon regeneration)|go:"GO:0031702"(type 1 angiotensin receptor binding)|go:"GO:0031959"(mineralocorticoid receptor signaling pathway)|go:"GO:0032024"(positive regulation of insulin secretion)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032516"(positive regulation of phosphoprotein phosphatase activity)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0033130"(acetylcholine receptor binding)|go:"GO:0033194"(response to hydroperoxide)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0020037"(heme binding)|interpro:IPR020693|interpro:IPR035588|interpro:IPR035589|interpro:IPR035860|interpro:IPR035963|interpro:IPR036860|interpro:IPR037838|interpro:IPR041046|interpro:IPR041155|interpro:IPR041381|mint:Q62120|rcsb pdb:2HDX|rcsb pdb:4GL9|reactome:R-MMU-1059683|reactome:R-MMU-110056|interpro:IPR020635|reactome:R-MMU-112411|reactome:R-MMU-1170546|go:"GO:0034612"(response to tumor necrosis factor)|go:"GO:0035166"(post-embryonic hemopoiesis)|go:"GO:0035401"("histone kinase activity (H3-Y41 specific)")|go:"GO:0035409"(histone H3-Y41 phosphorylation)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035722"(interleukin-12-mediated signaling pathway)|go:"GO:0036016"(cellular response to interleukin-3)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042393"(histone binding)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042802"(identical protein binding)|go:"GO:0042976"(activation of Janus kinase activity)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0034050"(programmed cell death induced by symbiont)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005131"(growth hormone receptor binding)|go:"GO:0005143"(interleukin-12 receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0007167"(enzyme linked receptor protein signaling pathway)|go:"GO:0005901"(caveola)|go:"GO:0005925"(focal adhesion)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007165"(signal transduction)|reactome:R-MMU-512988|reactome:R-MMU-5673000|reactome:R-MMU-5673001|reactome:R-MMU-6785807|reactome:R-MMU-6788467|reactome:R-MMU-69231|reactome:R-MMU-877300|reactome:R-MMU-877312|reactome:R-MMU-8854691|reactome:R-MMU-8984722|reactome:R-MMU-9020591|reactome:R-MMU-9020933|reactome:R-MMU-9020956|reactome:R-MMU-9027276|reactome:R-MMU-9027284|reactome:R-MMU-912526|reactome:R-MMU-9674555|reactome:R-MMU-9705462|reactome:R-MMU-982772|reactome:R-MMU-983231|reactome:R-MMU-1433557|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0007260"(tyrosine phosphorylation of STAT protein)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008631"(intrinsic apoptotic signaling pathway in response to oxidative stress)|go:"GO:0009755"(hormone-mediated signaling pathway)|go:"GO:0010667"(negative regulation of cardiac muscle cell apoptotic process)|go:"GO:0010811"(positive regulation of cell-substrate adhesion)|go:"GO:0012505"(endomembrane system)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019901"(protein kinase binding)|go:"GO:0043392"(negative regulation of DNA binding)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045348"(positive regulation of MHC class II biosynthetic process)|go:"GO:0045428"(regulation of nitric oxide biosynthetic process)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0045597"(positive regulation of cell differentiation)|go:"GO:0045822"(negative regulation of heart contraction)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046677"(response to antibiotic)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0048008"(platelet-derived growth factor receptor signaling pathway)|go:"GO:0043388"(positive regulation of DNA binding)|dip:DIP-60238N|refseq:XP_011245457.1	-	-	-	figure legend:Fig. 7D lane 4|agonist:IL-23|dataset:IBD - Inflammatory bowel disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-ba_f3)|taxid:10090(Mouse pro B cells IL-3 dependent)	-	2015/07/15	2021/02/11	rogid:j3Kjewnfoxv3Dvie81Sh0xkasn89606	rogid:pdjCNCHmNTiJ1gGtJyiWoGgtq4I10090	rigid:IrlPjrAfJnF0lmWVw8hDAF/GNUo	false	myc tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q5VWK5	uniprotkb:P42227	intact:EBI-10248005|uniprotkb:Q8NFQ9|uniprotkb:Q96AS1|uniprotkb:Q4VGP3|uniprotkb:Q8IW84|uniprotkb:Q4VGP5|uniprotkb:Q4VGP6|uniprotkb:Q4VGP2|uniprotkb:Q5VWK7|uniprotkb:Q4VGP1|uniprotkb:Q4VGP4|uniprotkb:C9JGX4|ensembl:ENSP00000321345	intact:EBI-602878|uniprotkb:A2A5D1|uniprotkb:B7ZC17|ensembl:ENSMUSP00000120152	psi-mi:il23r_human(display_long)|uniprotkb:IL23R(gene name)|psi-mi:IL23R(display_short)	psi-mi:stat3_mouse(display_long)|uniprotkb:Acute-phase response factor(gene name synonym)|uniprotkb:Stat3(gene name)|psi-mi:Stat3(display_short)|uniprotkb:Aprf(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Parham et al. (2002)	imex:IM-24780|pubmed:12023369	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10954052|imex:IM-24780-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_653302.2|refseq:XP_005270573.1|refseq:XP_011539092.1|refseq:XP_011539093.1|ensembl:ENSG00000162594(gene)|ensembl:ENST00000347310(transcript)|go:"GO:0001916"(positive regulation of T cell mediated cytotoxicity)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0002827"(positive regulation of T-helper 1 type immune response)|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010536"(positive regulation of activation of Janus kinase activity)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019955"(cytokine binding)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032693"(negative regulation of interleukin-10 production)|go:"GO:0032725"(positive regulation of granulocyte macrophage colony-stimulating factor production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032740"(positive regulation of interleukin-17 production)|go:"GO:0032819"(positive regulation of natural killer cell proliferation)|go:"GO:0034341"(response to interferon-gamma)|go:"GO:0038155"(interleukin-23-mediated signaling pathway)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042104"(positive regulation of activated T cell proliferation)|go:"GO:0042509"(regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0043235"(receptor complex)|go:"GO:0043382"(positive regulation of memory T cell differentiation)|go:"GO:0045672"(positive regulation of osteoclast differentiation)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0051135"(positive regulation of NK T cell activation)|go:"GO:0072536"(interleukin-23 receptor complex)|go:"GO:2000318"(positive regulation of T-helper 17 type immune response)|go:"GO:2000330"(positive regulation of T-helper 17 cell lineage commitment)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036116|rcsb pdb:5MZV|rcsb pdb:6WDQ|reactome:R-HSA-6785807|reactome:R-HSA-9020933	refseq:NP_998824.1|refseq:NP_998825.1|dip:DIP-442N|ensembl:ENSMUSG00000004040(gene)|ensembl:ENSMUST00000127638(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001659"(temperature homeostasis)|go:"GO:0001754"(eye photoreceptor cell differentiation)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0004879"(nuclear receptor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006952"(defense response)|go:"GO:0006953"(acute-phase response)|go:"GO:0006954"(inflammatory response)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0007568"(aging)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010730"(negative regulation of hydrogen peroxide biosynthetic process)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016310"(phosphorylation)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019953"(sexual reproduction)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030522"(intracellular receptor signaling pathway)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0031730"(CCR5 chemokine receptor binding)|go:"GO:0032355"(response to estradiol)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032870"(cellular response to hormone stimulus)|go:"GO:0033210"(leptin-mediated signaling pathway)|go:"GO:0034097"(response to cytokine)|go:"GO:0035259"(glucocorticoid receptor binding)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042493"|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042755"(eating behavior)|go:"GO:0042789"(mRNA transcription by RNA polymerase II)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0044320"(cellular response to leptin stimulus)|go:"GO:0044321"(response to leptin)|go:"GO:0045471"(response to ethanol)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045747"(positive regulation of Notch signaling pathway)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046902"(regulation of mitochondrial membrane permeability)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048708"(astrocyte differentiation)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060019"(radial glial cell differentiation)|go:"GO:0060259"(regulation of feeding behavior)|go:"GO:0060396"(growth hormone receptor signaling pathway)|go:"GO:0060397"(growth hormone receptor signaling pathway via JAK-STAT)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070102"(interleukin-6-mediated signaling pathway)|go:"GO:0070878"(primary miRNA binding)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0072538"(T-helper 17 type immune response)|go:"GO:0072540"(T-helper 17 cell lineage commitment)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:0097009"(energy homeostasis)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099527"(postsynapse to nucleus signaling pathway)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902728"(positive regulation of growth factor dependent skeletal muscle satellite cell proliferation)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1904685"(positive regulation of metalloendopeptidase activity)|go:"GO:1905564"(positive regulation of vascular endothelial cell proliferation)|go:"GO:1905618"(positive regulation of miRNA-mediated gene silencing by inhibition of translation)|go:"GO:2000635"(negative regulation of primary miRNA processing)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2000737"(negative regulation of stem cell differentiation)|go:"GO:2001171"(positive regulation of ATP biosynthetic process)|go:"GO:2001223"(negative regulation of neuron migration)|interpro:IPR000980(SH2 motif)|interpro:IPR001217(STAT transcription factor, core)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR012345(STAT transcription factor, DNA-binding, subdomain)|interpro:IPR013799(STAT transcription factor, protein interaction)|interpro:IPR013800(STAT transcription factor, all-alpha)|interpro:IPR013801(STAT transcription factor, DNA-binding)|interpro:IPR015988(STAT transcription factor, coiled coil)|interpro:IPR035855|interpro:IPR036535|interpro:IPR036860|mint:P42227|rcsb pdb:1BG1|rcsb pdb:3CWG|rcsb pdb:4E68|rcsb pdb:4ZIA|reactome:R-MMU-1059683|reactome:R-MMU-1266695|reactome:R-MMU-1433557|reactome:R-MMU-186763|reactome:R-MMU-6783783|reactome:R-MMU-6785807|reactome:R-MMU-8849474|reactome:R-MMU-8854691|reactome:R-MMU-8875791|reactome:R-MMU-8984722|reactome:R-MMU-8985947|reactome:R-MMU-9008059|reactome:R-MMU-9020933|reactome:R-MMU-9020956|reactome:R-MMU-9020958|reactome:R-MMU-8983432	-	-	-	figure legend:Fig. 7D lane 4|agonist:IL-23|dataset:IBD - Inflammatory bowel disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-ba_f3)|taxid:10090(Mouse pro B cells IL-3 dependent)	-	2015/07/15	2021/02/11	rogid:j3Kjewnfoxv3Dvie81Sh0xkasn89606	rogid:jWu9RTbZkTUtGrXQlg1K79zHowM10090	rigid:IrlPjrAfJnF0lmWVw8hDAF/GNUo	false	myc tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)