#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:O43586	uniprotkb:Q05209	intact:EBI-1050964|uniprotkb:O43585|uniprotkb:O95657|uniprotkb:B5BUK4|uniprotkb:B5BU74|ensembl:ENSP00000452746	intact:EBI-2266035|uniprotkb:Q16130|uniprotkb:Q59FD6|uniprotkb:Q75MN8|uniprotkb:Q86XU4|uniprotkb:A4D1C5|uniprotkb:E9PBR5|uniprotkb:B4DKY2|uniprotkb:E9PEH9|intact:EBI-28974655|ensembl:ENSP00000248594	psi-mi:ppip1_human(display_long)|uniprotkb:CD2-binding protein 1(gene name synonym)|uniprotkb:H-PIP(gene name synonym)|uniprotkb:PSTPIP1(gene name)|psi-mi:PSTPIP1(display_short)|uniprotkb:CD2BP1(gene name synonym)	psi-mi:ptn12_human(display_long)|uniprotkb:PTPN12(gene name)|psi-mi:PTPN12(display_short)|uniprotkb:Protein-tyrosine phosphatase G1(gene name synonym)|uniprotkb:PTP-PEST(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Wise et al. (2002)	pubmed:11971877|imex:IM-23965	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-10683839|imex:IM-23965-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_003969.2|refseq:NP_001308064.1|refseq:NP_001308066.1|ensembl:ENSG00000140368(gene)|ensembl:ENST00000558012(transcript)|go:"GO:0001931"(uropod)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0006897"(endocytosis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007155"(cell adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0016020"(membrane)|go:"GO:0030027"(lamellipodium)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0032154"(cleavage furrow)|go:"GO:0042802"(identical protein binding)|go:"GO:0045087"(innate immune response)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051015"(actin filament binding)|interpro:IPR001060(Cdc15/Fes/CIP4)|interpro:IPR001452(Src homology-3)|interpro:IPR027267|interpro:IPR030777|interpro:IPR031160|interpro:IPR036028|mint:O43586|rcsb pdb:2DIL|reactome:R-HSA-844456|reactome:R-HSA-9660826	ensembl:ENSP00000248594|ensembl:ENST00000415482|ensembl:ENSP00000392429|ensembl:ENST00000435495|ensembl:ENSP00000397991|refseq:NP_001124480.1|refseq:NP_001124481.1|refseq:NP_002826.3|ensembl:ENSG00000127947(gene)|ensembl:ENST00000248594(transcript)|go:"GO:0002102"(podosome)|go:"GO:0004721"(phosphoprotein phosphatase activity)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0004726"(non-membrane spanning protein tyrosine phosphatase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005925"(focal adhesion)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0035335"(peptidyl-tyrosine dephosphorylation)|go:"GO:0042058"(regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0042246"(tissue regeneration)|go:"GO:0042995"(cell projection)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:1901185"(negative regulation of ERBB signaling pathway)|go:"GO:2000587"(negative regulation of platelet-derived growth factor receptor-beta signaling pathway)|interpro:IPR000242(Protein-tyrosine phosphatase, receptor/non-receptor type)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR003595(Protein-tyrosine phosphatase, catalytic)|interpro:IPR012266(Protein-tyrosine phosphatase, non-receptor type-12)|interpro:IPR016130(Protein-tyrosine phosphatase, active site)|interpro:IPR029021|mint:Q05209|rcsb pdb:5HDE|rcsb pdb:5J8R|rcsb pdb:5O2P|reactome:R-HSA-1250196|reactome:R-HSA-182971|reactome:R-HSA-186797|reactome:R-HSA-8863795|reactome:R-HSA-9008059|reactome:R-HSA-9634285	-	-	-	figure legend:no fig|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2015/02/24	2015/02/24	rogid:JWK4dCYdcVF6mKwe+hoOri1wwps9606	rogid:0oOB8y5Czi6hL7BStYgqSiVv1Bo9606	intact-crc:E3AC7E8448EE971D|rigid:U7D6qpY1ATfE97qvs2CmrXMIEyQ	false	-	sufficient binding region:749-780	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q05209	uniprotkb:O43586	intact:EBI-2266035|uniprotkb:Q16130|uniprotkb:Q59FD6|uniprotkb:Q75MN8|uniprotkb:Q86XU4|uniprotkb:A4D1C5|uniprotkb:E9PBR5|uniprotkb:B4DKY2|uniprotkb:E9PEH9|intact:EBI-28974655|ensembl:ENSP00000248594	intact:EBI-1050964|uniprotkb:O43585|uniprotkb:O95657|uniprotkb:B5BUK4|uniprotkb:B5BU74|ensembl:ENSP00000452746	psi-mi:ptn12_human(display_long)|uniprotkb:PTPN12(gene name)|psi-mi:PTPN12(display_short)|uniprotkb:Protein-tyrosine phosphatase G1(gene name synonym)|uniprotkb:PTP-PEST(gene name synonym)	psi-mi:ppip1_human(display_long)|uniprotkb:CD2-binding protein 1(gene name synonym)|uniprotkb:H-PIP(gene name synonym)|uniprotkb:PSTPIP1(gene name)|psi-mi:PSTPIP1(display_short)|uniprotkb:CD2BP1(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Wise et al. (2002)	pubmed:11971877|imex:IM-23965	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-10683813|imex:IM-23965-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSP00000248594|ensembl:ENST00000415482|ensembl:ENSP00000392429|ensembl:ENST00000435495|ensembl:ENSP00000397991|refseq:NP_001124480.1|refseq:NP_001124481.1|refseq:NP_002826.3|ensembl:ENSG00000127947(gene)|ensembl:ENST00000248594(transcript)|go:"GO:0002102"(podosome)|go:"GO:0004721"(phosphoprotein phosphatase activity)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0004726"(non-membrane spanning protein tyrosine phosphatase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005925"(focal adhesion)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0035335"(peptidyl-tyrosine dephosphorylation)|go:"GO:0042058"(regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0042246"(tissue regeneration)|go:"GO:0042995"(cell projection)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:1901185"(negative regulation of ERBB signaling pathway)|go:"GO:2000587"(negative regulation of platelet-derived growth factor receptor-beta signaling pathway)|interpro:IPR000242(Protein-tyrosine phosphatase, receptor/non-receptor type)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR003595(Protein-tyrosine phosphatase, catalytic)|interpro:IPR012266(Protein-tyrosine phosphatase, non-receptor type-12)|interpro:IPR016130(Protein-tyrosine phosphatase, active site)|interpro:IPR029021|mint:Q05209|rcsb pdb:5HDE|rcsb pdb:5J8R|rcsb pdb:5O2P|reactome:R-HSA-1250196|reactome:R-HSA-182971|reactome:R-HSA-186797|reactome:R-HSA-8863795|reactome:R-HSA-9008059|reactome:R-HSA-9634285	refseq:NP_003969.2|refseq:NP_001308064.1|refseq:NP_001308066.1|ensembl:ENSG00000140368(gene)|ensembl:ENST00000558012(transcript)|go:"GO:0001931"(uropod)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0006897"(endocytosis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007155"(cell adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0016020"(membrane)|go:"GO:0030027"(lamellipodium)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0032154"(cleavage furrow)|go:"GO:0042802"(identical protein binding)|go:"GO:0045087"(innate immune response)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051015"(actin filament binding)|interpro:IPR001060(Cdc15/Fes/CIP4)|interpro:IPR001452(Src homology-3)|interpro:IPR027267|interpro:IPR030777|interpro:IPR031160|interpro:IPR036028|mint:O43586|rcsb pdb:2DIL|reactome:R-HSA-844456|reactome:R-HSA-9660826	omim:604416(see-also)	-	-	figure legend:no fig|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2015/02/24	2015/02/24	rogid:0oOB8y5Czi6hL7BStYgqSiVv1Bo9606	rogid:JWK4dCYdcVF6mKwe+hoOri1wwps9606	intact-crc:326BDF3DEE367373|rigid:U7D6qpY1ATfE97qvs2CmrXMIEyQ	false	sufficient binding region:749-780	mutation decreasing interaction:250-250|mutation decreasing interaction:230-230	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P06729	uniprotkb:O43586	intact:EBI-3912464|uniprotkb:Q96TE5|ensembl:ENSP00000358490	intact:EBI-1050964|uniprotkb:O43585|uniprotkb:O95657|uniprotkb:B5BUK4|uniprotkb:B5BU74|ensembl:ENSP00000452746	psi-mi:cd2_human(display_long)|uniprotkb:CD2(gene name)|psi-mi:CD2(display_short)|uniprotkb:SRBC(gene name synonym)|uniprotkb:Erythrocyte receptor(gene name synonym)|uniprotkb:LFA-2(gene name synonym)|uniprotkb:LFA-3 receptor(gene name synonym)|uniprotkb:Rosette receptor(gene name synonym)|uniprotkb:T-cell surface antigen T11/Leu-5(gene name synonym)	psi-mi:ppip1_human(display_long)|uniprotkb:CD2-binding protein 1(gene name synonym)|uniprotkb:H-PIP(gene name synonym)|uniprotkb:PSTPIP1(gene name)|psi-mi:PSTPIP1(display_short)|uniprotkb:CD2BP1(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Wise et al. (2002)	pubmed:11971877|imex:IM-23965	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-10683876|imex:IM-23965-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001758.2|ensembl:ENST00000369478(transcript)|go:"GO:0001766"(membrane raft polarization)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006915"(apoptotic process)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0030101"(natural killer cell activation)|go:"GO:0030887"(positive regulation of myeloid dendritic cell activation)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042110"(T cell activation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043621"(protein self-association)|go:"GO:0045121"(membrane raft)|go:"GO:0045580"(regulation of T cell differentiation)|go:"GO:0046658"(anchored component of plasma membrane)|go:"GO:0098609"(cell-cell adhesion)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015632(CD2)|interpro:IPR036179|mint:P06729|rcsb pdb:1CDB|rcsb pdb:1GYA|rcsb pdb:1HNF|rcsb pdb:1L2Z|rcsb pdb:1QA9|rcsb pdb:2J6O|rcsb pdb:2J7I|reactome:R-HSA-202733|ensembl:ENSG00000116824(gene)|refseq:NP_001315538.1	refseq:NP_003969.2|refseq:NP_001308064.1|refseq:NP_001308066.1|ensembl:ENSG00000140368(gene)|ensembl:ENST00000558012(transcript)|go:"GO:0001931"(uropod)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0006897"(endocytosis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007155"(cell adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0016020"(membrane)|go:"GO:0030027"(lamellipodium)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0032154"(cleavage furrow)|go:"GO:0042802"(identical protein binding)|go:"GO:0045087"(innate immune response)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051015"(actin filament binding)|interpro:IPR001060(Cdc15/Fes/CIP4)|interpro:IPR001452(Src homology-3)|interpro:IPR027267|interpro:IPR030777|interpro:IPR031160|interpro:IPR036028|mint:O43586|rcsb pdb:2DIL|reactome:R-HSA-844456|reactome:R-HSA-9660826	-	-	comment:PAPA variants glu250gln and asp230thr interact.	figure legend:no fig|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2015/02/24	2015/02/24	rogid:GN7E4kazkOZr2RuMuSMu5WGrbsE9606	rogid:JWK4dCYdcVF6mKwe+hoOri1wwps9606	intact-crc:FEDED04BDA67F090|rigid:bxBX9vFrL94Uy5Sg56zMUYvM4mY	false	sufficient binding region:251-351	necessary binding region:359..359-416("IPR001452)")	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)