#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P51682	uniprotkb:P06332	intact:EBI-11170173|uniprotkb:O35313|uniprotkb:O35891|uniprotkb:P97308|uniprotkb:P97405|uniprotkb:Q3ZAZ8|uniprotkb:Q61867|ensembl:ENSMUSP00000107069	intact:EBI-1404|ensembl:ENSMUSP00000024044	psi-mi:ccr5_mouse(display_long)|uniprotkb:MIP-1 alpha receptor(gene name synonym)|uniprotkb:Ccr5(gene name)|psi-mi:Ccr5(display_short)|uniprotkb:Cmkbr5(gene name synonym)	psi-mi:cd4_mouse(display_long)|uniprotkb:Cd4(gene name)|psi-mi:Cd4(display_short)|uniprotkb:T-cell surface antigen T4/Leu-3(gene name synonym)|uniprotkb:T-cell differentiation antigen L3T4(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Xiao et al. (2000)	imex:IM-24493|pubmed:10816381	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-11170215|imex:IM-24493-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_034047.2|ensembl:ENSMUSG00000079227(gene)|ensembl:ENSMUST00000111442(transcript)|go:"GO:0003779"(actin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006952"(defense response)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0014808"(release of sequestered calcium ion into cytosol by sarcoplasmic reticulum)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016493"(C-C chemokine receptor activity)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019957"(C-C chemokine binding)|go:"GO:0022409"(positive regulation of cell-cell adhesion)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030517"(negative regulation of axon extension)|go:"GO:0031622"(positive regulation of fever generation)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0042802"(identical protein binding)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0060139"(positive regulation of apoptotic process by virus)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0070723"(response to cholesterol)|go:"GO:0070997"(neuron death)|go:"GO:0071791"("chemokine (C-C motif) ligand 5 binding")|go:"GO:2000110"(negative regulation of macrophage apoptotic process)|go:"GO:2000178"(negative regulation of neural precursor cell proliferation)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR000355(Chemokine receptor)|interpro:IPR002240(C-C chemokine receptor, type 5)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|reactome:R-MMU-380108|reactome:R-MMU-418594	refseq:NP_038516.1|ensembl:ENSMUSG00000023274(gene)|ensembl:ENSMUST00000024044(transcript)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006948"(induction by virus of host cell-cell fusion)|go:"GO:0007155"(cell adhesion)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010524"(positive regulation of calcium ion transport into cytosol)|go:"GO:0015026"(coreceptor activity)|go:"GO:0019865"(immunoglobulin binding)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0030217"(T cell differentiation)|go:"GO:0030225"(macrophage differentiation)|go:"GO:0032507"(maintenance of protein location in cell)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0035397"(helper T cell enhancement of adaptive immune response)|go:"GO:0035723"(interleukin-15-mediated signaling pathway)|go:"GO:0042011"(interleukin-16 binding)|go:"GO:0042012"(interleukin-16 receptor activity)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042110"(T cell activation)|go:"GO:0042289"(MHC class II protein binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0045058"(T cell selection)|go:"GO:0045121"(membrane raft)|go:"GO:0045657"(positive regulation of monocyte differentiation)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046598"(positive regulation of viral entry into host cell)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0050850"(positive regulation of calcium-mediated signaling)|go:"GO:0050863"(regulation of T cell activation)|go:"GO:0050870"(positive regulation of T cell activation)|go:"GO:0051924"(regulation of calcium ion transport)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0097011"(cellular response to granulocyte macrophage colony-stimulating factor stimulus)|go:"GO:1990782"(protein tyrosine kinase binding)|interpro:IPR000973(T-cell surface antigen CD4)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015274(CD4, extracellular)|interpro:IPR021963|interpro:IPR036179|mint:P06332|reactome:R-MMU-1462054|reactome:R-MMU-202424|reactome:R-MMU-202427|reactome:R-MMU-202430|reactome:R-MMU-202433|reactome:R-MMU-389948|reactome:R-MMU-449836|reactome:R-MMU-8856825|reactome:R-MMU-8856828	-	-	-	figure legend:4|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-nih_3t3)|taxid:10090(Mus musculus Swiss NIH 3t3 embryo fibroblast cells)	-	2015/08/24	2015/08/24	rogid:MXaZLnGKM2iQrHa9iMKPyEjep0g10090	rogid:80TDw5kSJXFKGKJpjZ7Rdb9gD1g10090	rigid:wDMyU8tf37poM+jQtxgTRArOFHU	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P01730	uniprotkb:P51681	intact:EBI-353826|uniprotkb:Q4ZGK2|uniprotkb:Q5U066|uniprotkb:Q9UDE5|uniprotkb:B2R737|uniprotkb:D3DUS5|ensembl:ENSP00000011653	intact:EBI-489374|uniprotkb:O14692|uniprotkb:O14693|uniprotkb:O14695|uniprotkb:O14696|uniprotkb:O14697|uniprotkb:O14698|uniprotkb:O14699|uniprotkb:O14700|uniprotkb:O14701|uniprotkb:O14702|uniprotkb:O14703|uniprotkb:O14704|uniprotkb:O14705|uniprotkb:O14706|uniprotkb:O14707|uniprotkb:O14708|uniprotkb:O15538|uniprotkb:Q9UPA4|ensembl:ENSP00000292303|ensembl:ENSP00000404881	psi-mi:cd4_human(display_long)|uniprotkb:CD4(gene name)|psi-mi:CD4(display_short)|uniprotkb:T-cell surface antigen T4/Leu-3(gene name synonym)	psi-mi:ccr5_human(display_long)|uniprotkb:HIV-1 fusion coreceptor(gene name synonym)|uniprotkb:CHEMR13(gene name synonym)|uniprotkb:CCR5(gene name)|psi-mi:CCR5(display_short)|uniprotkb:CMKBR5(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Xiao et al. (2000)	imex:IM-24493|pubmed:10816381	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-11170226|imex:IM-24493-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000607.1|rcsb pdb:1CDI|rcsb pdb:1CDJ|rcsb pdb:1CDU|rcsb pdb:1CDY|rcsb pdb:1G9M|rcsb pdb:1G9N|rcsb pdb:1GC1|rcsb pdb:1JL4|rcsb pdb:1OPN|rcsb pdb:1OPT|rcsb pdb:1OPW|rcsb pdb:1Q68|rcsb pdb:1RZJ|rcsb pdb:1RZK|rcsb pdb:1WBR|rcsb pdb:1WIO|rcsb pdb:1WIP|rcsb pdb:1WIQ|rcsb pdb:2B4C|rcsb pdb:1CDH|rcsb pdb:2JKR|rcsb pdb:2JKT|reactome:R-HSA-202430|reactome:R-HSA-202433|reactome:R-HSA-202427|reactome:R-HSA-389948|reactome:R-HSA-449836|reactome:R-HSA-8856825|reactome:R-HSA-8856828|ensembl:ENST00000011653(transcript)|go:"GO:0045657"(positive regulation of monocyte differentiation)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046598"(positive regulation of viral entry into host cell)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0050850"(positive regulation of calcium-mediated signaling)|go:"GO:0050863"(regulation of T cell activation)|go:"GO:0050870"(positive regulation of T cell activation)|go:"GO:0051924"(regulation of calcium ion transport)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0097011"(cellular response to granulocyte macrophage colony-stimulating factor stimulus)|go:"GO:1990782"(protein tyrosine kinase binding)|interpro:IPR000973(T-cell surface antigen CD4)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015274(CD4, extracellular)|interpro:IPR021963|interpro:IPR036179|mint:P01730|go:"GO:0001618"(virus receptor activity)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002250"(adaptive immune response)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005201"(extracellular matrix structural constituent)|go:"GO:0005769"(early endosome)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006948"(induction by virus of host cell-cell fusion)|go:"GO:0006955"(immune response)|go:"GO:0007155"(cell adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007167"(enzyme linked receptor protein signaling pathway)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0015026"(coreceptor activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0030217"(T cell differentiation)|go:"GO:0030225"(macrophage differentiation)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0032507"(maintenance of protein location in cell)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0035397"(helper T cell enhancement of adaptive immune response)|go:"GO:0035723"(interleukin-15-mediated signaling pathway)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042011"(interleukin-16 binding)|go:"GO:0042012"(interleukin-16 receptor activity)|go:"GO:0042101"(T cell receptor complex)|go:"GO:0042110"(T cell activation)|go:"GO:0042289"(MHC class II protein binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0045058"(T cell selection)|go:"GO:0045121"(membrane raft)|rcsb pdb:2KLU|rcsb pdb:2NXY|rcsb pdb:2NXZ|rcsb pdb:2NY0|rcsb pdb:2NY1|rcsb pdb:2NY2|rcsb pdb:2NY3|rcsb pdb:2NY4|rcsb pdb:2NY5|rcsb pdb:2NY6|rcsb pdb:2QAD|rcsb pdb:3B71|rcsb pdb:3CD4|rcsb pdb:3J70|rcsb pdb:3JCB|rcsb pdb:3JCC|rcsb pdb:3JWD|rcsb pdb:3JWO|rcsb pdb:3LQA|rcsb pdb:3O2D|rcsb pdb:3S4S|rcsb pdb:3S5L|rcsb pdb:3T0E|rcsb pdb:4H8W|rcsb pdb:4JM2|rcsb pdb:4P9H|rcsb pdb:4Q6I|rcsb pdb:4R2G|rcsb pdb:4R4H|rcsb pdb:4RQS|rcsb pdb:5A7X|rcsb pdb:5A8H|rcsb pdb:5CAY|rcsb pdb:5THR|rcsb pdb:5U1F|rcsb pdb:5VN3|rcsb pdb:6CM3|rcsb pdb:6EDU|rcsb pdb:6L1Y|rcsb pdb:6MEO|rcsb pdb:6MET|rcsb pdb:6OPN|rcsb pdb:6OPO|rcsb pdb:6OPP|rcsb pdb:6OPQ|rcsb pdb:6QH6|rcsb pdb:6QH7|rcsb pdb:6U0L|rcsb pdb:6U0N|rcsb pdb:6URI|rcsb pdb:6X5B|rcsb pdb:6X5C|reactome:R-HSA-1462054|reactome:R-HSA-167590|reactome:R-HSA-173107|reactome:R-HSA-180534|reactome:R-HSA-202424|ensembl:ENSG00000010610(gene)|dip:DIP-617N	go:"GO:0019722"(calcium-mediated signaling)|refseq:NP_000570.1|refseq:NP_001093638.1|ensembl:ENSG00000160791(gene)|ensembl:ENST00000292303(transcript)|ensembl:ENST00000445772(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001618"(virus receptor activity)|go:"GO:0002407"(dendritic cell chemotaxis)|go:"GO:0003779"(actin binding)|go:"GO:0004435"(phosphatidylinositol phospholipase C activity)|go:"GO:0004950"(chemokine receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0006968"(cellular defense response)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0014808"(release of sequestered calcium ion into cytosol by sarcoplasmic reticulum)|go:"GO:0015026"(coreceptor activity)|go:"GO:0016493"(C-C chemokine receptor activity)|rcsb pdb:4MBS|rcsb pdb:5UIW|rcsb pdb:5YD3|rcsb pdb:5YD4|rcsb pdb:5YD5|rcsb pdb:5YY4|rcsb pdb:6FGP|rcsb pdb:6MEO|rcsb pdb:6MET|rcsb pdb:7O7F|reactome:R-HSA-173107|reactome:R-HSA-380108|reactome:R-HSA-418594|reactome:R-HSA-6783783|rcsb pdb:2RRS|go:"GO:0023052"(signaling)|go:"GO:0042802"(identical protein binding)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0070723"(response to cholesterol)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071791"("chemokine (C-C motif) ligand 5 binding")|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR000355(Chemokine receptor)|interpro:IPR002240(C-C chemokine receptor, type 5)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|mint:P51681|rcsb pdb:1ND8|rcsb pdb:1NE0|rcsb pdb:1OPN|rcsb pdb:1OPT|rcsb pdb:1OPW|rcsb pdb:2L87|go:"GO:0019957"(C-C chemokine binding)|rcsb pdb:2MZX|rcsb pdb:2RLL|dip:DIP-5866N	-	-	-	figure legend:4|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-mddc)|taxid:9606(Human Monocyte-derived dendritic cell)	-	2015/08/24	2015/08/24	rogid:twRRh+v4xPOIlmeD9jl+Jpqjle09606	rogid:qpXGapPDi9co6c1kf2NgfM1qkA89606	rigid:X7+DZ/ACwaMG6M2JUUFWTl8gP1c	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P61073	uniprotkb:P03377-PRO_0000038388	intact:EBI-489411|uniprotkb:Q53S69|uniprotkb:O60835|uniprotkb:P30991|uniprotkb:P56438|uniprotkb:Q9UKN2|uniprotkb:B2R5N0|uniprotkb:Q9BXA0|ensembl:ENSP00000241393	intact:EBI-11172999	psi-mi:cxcr4_human(display_long)|uniprotkb:Stromal cell-derived factor 1 receptor(gene name synonym)|uniprotkb:Fusin(gene name synonym)|uniprotkb:Leukocyte-derived seven transmembrane domain receptor(gene name synonym)|uniprotkb:LCR1(gene name synonym)|uniprotkb:FB22(gene name synonym)|uniprotkb:NPYRL(gene name synonym)|uniprotkb:HM89(gene name synonym)|uniprotkb:CXCR4(gene name)|psi-mi:CXCR4(display_short)|uniprotkb:Lipopolysaccharide-associated protein 3(gene name synonym)	psi-mi:p03377-pro_0000038388(display_long)|uniprotkb:env(gene name)|psi-mi:env(display_short)|uniprotkb:Env polyprotein(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Xiao et al. (2000)	imex:IM-24493|pubmed:10816381	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:11686(hv1br)|taxid:11686("Human immunodeficiency virus type 1 group M subtype B (isolate BRU/LAI)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-11170240|imex:IM-24493-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001008540.1|refseq:NP_003458.1|refseq:NP_001334985.1|refseq:NP_001334988.1|refseq:NP_001334989.1|dip:DIP-34773N|dip:DIP-46290N|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007420"(brain development)|go:"GO:0008038"(neuron recognition)|go:"GO:0009615"(response to virus)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0014823"(response to activity)|go:"GO:0015026"(coreceptor activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016493"(C-C chemokine receptor activity)|go:"GO:0016494"(C-X-C chemokine receptor activity)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019957"(C-C chemokine binding)|go:"GO:0022008"(neurogenesis)|go:"GO:0022029"(telencephalon cell migration)|go:"GO:0030054"(cell junction)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0031252"(cell leading edge)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032027"(myosin light chain binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035470"(positive regulation of vascular wound healing)|go:"GO:0035690"|go:"GO:0038147"(C-X-C motif chemokine 12 receptor activity)|go:"GO:0038160"(CXCL12-activated CXCR4 signaling pathway)|go:"GO:0043067"(regulation of programmed cell death)|go:"GO:0043130"(ubiquitin binding)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|interpro:IPR022726|mint:P61073|rcsb pdb:2K03|rcsb pdb:2K04|rcsb pdb:2K05|rcsb pdb:2N55|rcsb pdb:3ODU|rcsb pdb:3OE0|rcsb pdb:3OE6|rcsb pdb:3OE8|rcsb pdb:3OE9|rcsb pdb:4RWS|reactome:R-HSA-173107|reactome:R-HSA-376176|reactome:R-HSA-380108|reactome:R-HSA-418594|go:"GO:0043217"(myelin maintenance)|go:"GO:0043278"(response to morphine)|go:"GO:0045446"(endothelial cell differentiation)|go:"GO:0048714"(positive regulation of oligodendrocyte differentiation)|go:"GO:0050792"(regulation of viral process)|go:"GO:0050920"(regulation of chemotaxis)|go:"GO:0050921"(positive regulation of chemotaxis)|go:"GO:0050965"(detection of temperature stimulus involved in sensory perception of pain)|go:"GO:0050966"(detection of mechanical stimulus involved in sensory perception of pain)|go:"GO:0051924"(regulation of calcium ion transport)|go:"GO:0060048"(cardiac muscle contraction)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0061154"(endothelial tube morphogenesis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1903861"(positive regulation of dendrite extension)|go:"GO:1905322"(positive regulation of mesenchymal stem cell migration)|go:"GO:1990478"(response to ultrasound)|go:"GO:2000448"(positive regulation of macrophage migration inhibitory factor signaling pathway)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR000355(Chemokine receptor)|interpro:IPR001277(C-X-C chemokine receptor, type 4)|ensembl:ENSG00000121966(gene)|ensembl:ENST00000241393(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001618"(virus receptor activity)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001764"(neuron migration)|go:"GO:0002064"(epithelial cell development)|go:"GO:0002407"(dendritic cell chemotaxis)|go:"GO:0003779"(actin binding)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)	intact:EBI-11172964(chain-parent)	-	-	chain-seq-start:33|chain-seq-end:516	figure legend:4|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-mddc)|taxid:9606(Human Monocyte-derived dendritic cell)	-	2015/08/24	2015/09/01	rogid:/DC0/+M1YsFLLfsDimppXSS/vpQ9606	rogid:V7yL80YqKK4uw/oVVTieeUxqCII11686	rigid:8xa9J3fO7GoDxeBUOGVUDGM5Wmk	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P61073	uniprotkb:P01730	intact:EBI-489411|uniprotkb:Q53S69|uniprotkb:O60835|uniprotkb:P30991|uniprotkb:P56438|uniprotkb:Q9UKN2|uniprotkb:B2R5N0|uniprotkb:Q9BXA0|ensembl:ENSP00000241393	intact:EBI-353826|uniprotkb:Q4ZGK2|uniprotkb:Q5U066|uniprotkb:Q9UDE5|uniprotkb:B2R737|uniprotkb:D3DUS5|ensembl:ENSP00000011653	psi-mi:cxcr4_human(display_long)|uniprotkb:Stromal cell-derived factor 1 receptor(gene name synonym)|uniprotkb:Fusin(gene name synonym)|uniprotkb:Leukocyte-derived seven transmembrane domain receptor(gene name synonym)|uniprotkb:LCR1(gene name synonym)|uniprotkb:FB22(gene name synonym)|uniprotkb:NPYRL(gene name synonym)|uniprotkb:HM89(gene name synonym)|uniprotkb:CXCR4(gene name)|psi-mi:CXCR4(display_short)|uniprotkb:Lipopolysaccharide-associated protein 3(gene name synonym)	psi-mi:cd4_human(display_long)|uniprotkb:CD4(gene name)|psi-mi:CD4(display_short)|uniprotkb:T-cell surface antigen T4/Leu-3(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Xiao et al. (2000)	imex:IM-24493|pubmed:10816381	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-11170240|imex:IM-24493-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001008540.1|refseq:NP_003458.1|refseq:NP_001334985.1|refseq:NP_001334988.1|refseq:NP_001334989.1|dip:DIP-34773N|dip:DIP-46290N|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007420"(brain development)|go:"GO:0008038"(neuron recognition)|go:"GO:0009615"(response to virus)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0014823"(response to activity)|go:"GO:0015026"(coreceptor activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016493"(C-C chemokine receptor activity)|go:"GO:0016494"(C-X-C chemokine receptor activity)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019957"(C-C chemokine binding)|go:"GO:0022008"(neurogenesis)|go:"GO:0022029"(telencephalon cell migration)|go:"GO:0030054"(cell junction)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0031252"(cell leading edge)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032027"(myosin light chain binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035470"(positive regulation of vascular wound healing)|go:"GO:0035690"|go:"GO:0038147"(C-X-C motif chemokine 12 receptor activity)|go:"GO:0038160"(CXCL12-activated CXCR4 signaling pathway)|go:"GO:0043067"(regulation of programmed cell death)|go:"GO:0043130"(ubiquitin binding)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|interpro:IPR022726|mint:P61073|rcsb pdb:2K03|rcsb pdb:2K04|rcsb pdb:2K05|rcsb pdb:2N55|rcsb pdb:3ODU|rcsb pdb:3OE0|rcsb pdb:3OE6|rcsb pdb:3OE8|rcsb pdb:3OE9|rcsb pdb:4RWS|reactome:R-HSA-173107|reactome:R-HSA-376176|reactome:R-HSA-380108|reactome:R-HSA-418594|go:"GO:0043217"(myelin maintenance)|go:"GO:0043278"(response to morphine)|go:"GO:0045446"(endothelial cell differentiation)|go:"GO:0048714"(positive regulation of oligodendrocyte differentiation)|go:"GO:0050792"(regulation of viral process)|go:"GO:0050920"(regulation of chemotaxis)|go:"GO:0050921"(positive regulation of chemotaxis)|go:"GO:0050965"(detection of temperature stimulus involved in sensory perception of pain)|go:"GO:0050966"(detection of mechanical stimulus involved in sensory perception of pain)|go:"GO:0051924"(regulation of calcium ion transport)|go:"GO:0060048"(cardiac muscle contraction)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0061154"(endothelial tube morphogenesis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1903861"(positive regulation of dendrite extension)|go:"GO:1905322"(positive regulation of mesenchymal stem cell migration)|go:"GO:1990478"(response to ultrasound)|go:"GO:2000448"(positive regulation of macrophage migration inhibitory factor signaling pathway)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR000355(Chemokine receptor)|interpro:IPR001277(C-X-C chemokine receptor, type 4)|ensembl:ENSG00000121966(gene)|ensembl:ENST00000241393(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001618"(virus receptor activity)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001764"(neuron migration)|go:"GO:0002064"(epithelial cell development)|go:"GO:0002407"(dendritic cell chemotaxis)|go:"GO:0003779"(actin binding)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)	refseq:NP_000607.1|rcsb pdb:1CDI|rcsb pdb:1CDJ|rcsb pdb:1CDU|rcsb pdb:1CDY|rcsb pdb:1G9M|rcsb pdb:1G9N|rcsb pdb:1GC1|rcsb pdb:1JL4|rcsb pdb:1OPN|rcsb pdb:1OPT|rcsb pdb:1OPW|rcsb pdb:1Q68|rcsb pdb:1RZJ|rcsb pdb:1RZK|rcsb pdb:1WBR|rcsb pdb:1WIO|rcsb pdb:1WIP|rcsb pdb:1WIQ|rcsb pdb:2B4C|rcsb pdb:1CDH|rcsb pdb:2JKR|rcsb pdb:2JKT|reactome:R-HSA-202430|reactome:R-HSA-202433|reactome:R-HSA-202427|reactome:R-HSA-389948|reactome:R-HSA-449836|reactome:R-HSA-8856825|reactome:R-HSA-8856828|ensembl:ENST00000011653(transcript)|go:"GO:0045657"(positive regulation of monocyte differentiation)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046598"(positive regulation of viral entry into host cell)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0050850"(positive regulation of calcium-mediated signaling)|go:"GO:0050863"(regulation of T cell activation)|go:"GO:0050870"(positive regulation of T cell activation)|go:"GO:0051924"(regulation of calcium ion transport)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0097011"(cellular response to granulocyte macrophage colony-stimulating factor stimulus)|go:"GO:1990782"(protein tyrosine kinase binding)|interpro:IPR000973(T-cell surface antigen CD4)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR008424(Immunoglobulin C2-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015274(CD4, extracellular)|interpro:IPR021963|interpro:IPR036179|mint:P01730|go:"GO:0001618"(virus receptor activity)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002250"(adaptive immune response)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005201"(extracellular matrix structural constituent)|go:"GO:0005769"(early endosome)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006948"(induction by virus of host cell-cell fusion)|go:"GO:0006955"(immune response)|go:"GO:0007155"(cell adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007167"(enzyme linked receptor protein signaling pathway)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0015026"(coreceptor activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0030217"(T cell differentiation)|go:"GO:0030225"(macrophage differentiation)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0032507"(maintenance of protein location in cell)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0035397"(helper T cell enhancement of adaptive immune response)|go:"GO:0035723"(interleukin-15-mediated signaling pathway)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042011"(interleukin-16 binding)|go:"GO:0042012"(interleukin-16 receptor activity)|go:"GO:0042101"(T cell receptor complex)|go:"GO:0042110"(T cell activation)|go:"GO:0042289"(MHC class II protein binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0045058"(T cell selection)|go:"GO:0045121"(membrane raft)|rcsb pdb:2KLU|rcsb pdb:2NXY|rcsb pdb:2NXZ|rcsb pdb:2NY0|rcsb pdb:2NY1|rcsb pdb:2NY2|rcsb pdb:2NY3|rcsb pdb:2NY4|rcsb pdb:2NY5|rcsb pdb:2NY6|rcsb pdb:2QAD|rcsb pdb:3B71|rcsb pdb:3CD4|rcsb pdb:3J70|rcsb pdb:3JCB|rcsb pdb:3JCC|rcsb pdb:3JWD|rcsb pdb:3JWO|rcsb pdb:3LQA|rcsb pdb:3O2D|rcsb pdb:3S4S|rcsb pdb:3S5L|rcsb pdb:3T0E|rcsb pdb:4H8W|rcsb pdb:4JM2|rcsb pdb:4P9H|rcsb pdb:4Q6I|rcsb pdb:4R2G|rcsb pdb:4R4H|rcsb pdb:4RQS|rcsb pdb:5A7X|rcsb pdb:5A8H|rcsb pdb:5CAY|rcsb pdb:5THR|rcsb pdb:5U1F|rcsb pdb:5VN3|rcsb pdb:6CM3|rcsb pdb:6EDU|rcsb pdb:6L1Y|rcsb pdb:6MEO|rcsb pdb:6MET|rcsb pdb:6OPN|rcsb pdb:6OPO|rcsb pdb:6OPP|rcsb pdb:6OPQ|rcsb pdb:6QH6|rcsb pdb:6QH7|rcsb pdb:6U0L|rcsb pdb:6U0N|rcsb pdb:6URI|rcsb pdb:6X5B|rcsb pdb:6X5C|reactome:R-HSA-1462054|reactome:R-HSA-167590|reactome:R-HSA-173107|reactome:R-HSA-180534|reactome:R-HSA-202424|ensembl:ENSG00000010610(gene)|dip:DIP-617N	-	-	-	figure legend:4|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-mddc)|taxid:9606(Human Monocyte-derived dendritic cell)	-	2015/08/24	2015/09/01	rogid:/DC0/+M1YsFLLfsDimppXSS/vpQ9606	rogid:twRRh+v4xPOIlmeD9jl+Jpqjle09606	rigid:8xa9J3fO7GoDxeBUOGVUDGM5Wmk	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)