#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:O75593	uniprotkb:Q15796	intact:EBI-1759806|uniprotkb:D3DWM4|ensembl:ENSP00000366534	intact:EBI-1040141|ensembl:ENSP00000262160|ensembl:ENSP00000384449	psi-mi:foxh1_human(display_long)|uniprotkb:FOXH1(gene name)|psi-mi:FOXH1(display_short)|uniprotkb:FAST1(gene name synonym)|uniprotkb:FAST2(gene name synonym)|uniprotkb:Forkhead activin signal transducer 1(gene name synonym)|uniprotkb:Forkhead activin signal transducer 2(gene name synonym)	psi-mi:smad2_human(display_long)|uniprotkb:SMAD2(gene name)|psi-mi:SMAD2(display_short)|uniprotkb:MADH2(gene name synonym)|uniprotkb:MADR2(gene name synonym)|uniprotkb:Mad-related protein 2(gene name synonym)|uniprotkb:SMAD family member 2(gene name synonym)|uniprotkb:JV18-1(gene name synonym)	psi-mi:"MI:0400"(affinity technology)	Zhou et al. (1998)	pubmed:9702198|imex:IM-23294	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-9844743|imex:IM-23294-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_003914.1|ensembl:ENSG00000160973(gene)|ensembl:ENST00000377317(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001947"(heart looping)|go:"GO:0003139"(secondary heart field specification)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0003215"(cardiac right ventricle morphogenesis)|go:"GO:0003222"(ventricular trabecula myocardium morphogenesis)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0032444"(activin responsive factor complex)|go:"GO:0033147"(negative regulation of intracellular estrogen receptor signaling pathway)|go:"GO:0035054"(embryonic heart tube anterior/posterior pattern specification)|go:"GO:0035909"(aorta morphogenesis)|go:"GO:0043425"(bHLH transcription factor binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046332"(SMAD binding)|go:"GO:0048318"(axial mesoderm development)|go:"GO:0050681"(androgen receptor binding)|go:"GO:0060766"(negative regulation of androgen receptor signaling pathway)|go:"GO:0070410"(co-SMAD binding)|go:"GO:0070412"(R-SMAD binding)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:1900164"(nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry)|interpro:IPR001766(Fork head transcription factor)|interpro:IPR030456|interpro:IPR036388|interpro:IPR036390|rcsb pdb:5XOC|reactome:R-HSA-1181150|reactome:R-HSA-1502540	refseq:NP_001003652.1|refseq:NP_005892.1|refseq:XP_006722514.1|ensembl:ENSG00000175387(gene)|ensembl:ENST00000262160(transcript)|ensembl:ENST00000402690(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001657"(ureteric bud development)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001706"(endoderm formation)|go:"GO:0001707"(mesoderm formation)|go:"GO:0003682"(chromatin binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005160"(transforming growth factor beta receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007182"(common-partner SMAD protein phosphorylation)|go:"GO:0007183"(SMAD protein complex assembly)|go:"GO:0007352"(zygotic specification of dorsal/ventral axis)|go:"GO:0007369"(gastrulation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0009749"(response to glucose)|go:"GO:0009791"(post-embryonic development)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0017015"(regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0019902"(phosphatase binding)|go:"GO:0023019"(signal transduction involved in regulation of gene expression)|go:"GO:0030073"(insulin secretion)|go:"GO:0030154"(cell differentiation)|go:"GO:0030324"(lung development)|go:"GO:0030325"(adrenal gland development)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0030513"(positive regulation of BMP signaling pathway)|go:"GO:0031016"(pancreas development)|go:"GO:0031053"(primary miRNA processing)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032444"(activin responsive factor complex)|go:"GO:0032924"(activin receptor signaling pathway)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034713"(type I transforming growth factor beta receptor binding)|go:"GO:0035265"(organ growth)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0038092"(nodal signaling pathway)|go:"GO:0042060"(wound healing)|go:"GO:0042802"(identical protein binding)|go:"GO:0045165"(cell fate commitment)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046332"(SMAD binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0048156"(tau protein binding)|go:"GO:0048340"(paraxial mesoderm morphogenesis)|go:"GO:0048617"(embryonic foregut morphogenesis)|go:"GO:0048701"(embryonic cranial skeleton morphogenesis)|go:"GO:0051098"(regulation of binding)|go:"GO:0060039"(pericardium development)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0062009"(secondary palate development)|go:"GO:0070410"(co-SMAD binding)|go:"GO:0070411"(I-SMAD binding)|go:"GO:0070412"(R-SMAD binding)|go:"GO:0070723"(response to cholesterol)|go:"GO:0071141"(SMAD protein complex)|go:"GO:0071144"(heteromeric SMAD protein complex)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1900224"(positive regulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry)|interpro:IPR001132(SMAD domain, Dwarfin-type)|interpro:IPR003619(MAD homology 1, Dwarfin-type)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR013019(MAD homology, MH1)|interpro:IPR013790(Dwarfin)|interpro:IPR017855(SMAD domain-like)|interpro:IPR036578|mint:Q15796|rcsb pdb:1DEV|rcsb pdb:1KHX|rcsb pdb:1U7V|rcsb pdb:2LB3|rcsb pdb:5XOD|rcsb pdb:5ZOJ|rcsb pdb:6M64|rcsb pdb:6ZVQ|rcsb pdb:7CO1|reactome:R-HSA-1181150|reactome:R-HSA-1502540|reactome:R-HSA-2173788|reactome:R-HSA-2173789|reactome:R-HSA-2173795|reactome:R-HSA-2173796|reactome:R-HSA-3304356|reactome:R-HSA-3311021|reactome:R-HSA-3315487|reactome:R-HSA-3656532|reactome:R-HSA-452723|reactome:R-HSA-5689880|reactome:R-HSA-9615017|reactome:R-HSA-9617828|refseq:XP_016881234.1|refseq:XP_016881235.1|refseq:XP_005258316.1|dip:DIP-29716N	-	-	-	figure legend:Fig. 2B|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/10/13	2014/11/17	rogid:uZzViiPJyxYi9PHrgIEN/ZBW5tI9606	rogid:B+vgtzdbCnUXt22sbXtPwuudTNs9606	intact-crc:06A4F41B58986B17|rigid:VQ0JWoSohHrhUDdBo8JWyMn6W4c	false	35s radiolabel:?-?|sufficient binding region:221-365	glutathione s tranferase tag:n-n|sufficient binding region:183-467(PS51076)	-	-	psi-mi:"MI:0833"(autoradiography)	psi-mi:"MI:0833"(autoradiography)
uniprotkb:O75593	intact:EBI-9844942	intact:EBI-1759806|uniprotkb:D3DWM4|ensembl:ENSP00000366534	-	psi-mi:foxh1_human(display_long)|uniprotkb:FOXH1(gene name)|psi-mi:FOXH1(display_short)|uniprotkb:FAST1(gene name synonym)|uniprotkb:FAST2(gene name synonym)|uniprotkb:Forkhead activin signal transducer 1(gene name synonym)|uniprotkb:Forkhead activin signal transducer 2(gene name synonym)	psi-mi:fbe(display_short)|psi-mi:EBI-9844942(display_long)	psi-mi:"MI:0413"(electrophoretic mobility shift assay)	Zhou et al. (1998)	pubmed:9702198|imex:IM-23294	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:-1(in vitro)|taxid:-1(In vitro)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-9844975|imex:IM-23294-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0680"(single stranded deoxyribonucleic acid)	refseq:NP_003914.1|ensembl:ENSG00000160973(gene)|ensembl:ENST00000377317(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001947"(heart looping)|go:"GO:0003139"(secondary heart field specification)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0003215"(cardiac right ventricle morphogenesis)|go:"GO:0003222"(ventricular trabecula myocardium morphogenesis)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0032444"(activin responsive factor complex)|go:"GO:0033147"(negative regulation of intracellular estrogen receptor signaling pathway)|go:"GO:0035054"(embryonic heart tube anterior/posterior pattern specification)|go:"GO:0035909"(aorta morphogenesis)|go:"GO:0043425"(bHLH transcription factor binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046332"(SMAD binding)|go:"GO:0048318"(axial mesoderm development)|go:"GO:0050681"(androgen receptor binding)|go:"GO:0060766"(negative regulation of androgen receptor signaling pathway)|go:"GO:0070410"(co-SMAD binding)|go:"GO:0070412"(R-SMAD binding)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:1900164"(nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry)|interpro:IPR001766(Fork head transcription factor)|interpro:IPR030456|interpro:IPR036388|interpro:IPR036390|rcsb pdb:5XOC|reactome:R-HSA-1181150|reactome:R-HSA-1502540	pubmed:9702198(primary-reference)	-	-	-	figure legend:FIG. 4C|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/10/13	2014/11/17	rogid:uZzViiPJyxYi9PHrgIEN/ZBW5tI9606	-	intact-crc:7ABE04BCE0B1F517	false	glutathione s tranferase tag:n-n|sufficient binding region:32..32-128..128	32p radiolabel:?-?	-	-	psi-mi:"MI:0833"(autoradiography)	psi-mi:"MI:0833"(autoradiography)
uniprotkb:O75593	intact:EBI-9844957	intact:EBI-1759806|uniprotkb:D3DWM4|ensembl:ENSP00000366534	-	psi-mi:foxh1_human(display_long)|uniprotkb:FOXH1(gene name)|psi-mi:FOXH1(display_short)|uniprotkb:FAST1(gene name synonym)|uniprotkb:FAST2(gene name synonym)|uniprotkb:Forkhead activin signal transducer 1(gene name synonym)|uniprotkb:Forkhead activin signal transducer 2(gene name synonym)	psi-mi:are(display_short)|psi-mi:EBI-9844957(display_long)	psi-mi:"MI:0413"(electrophoretic mobility shift assay)	Zhou et al. (1998)	pubmed:9702198|imex:IM-23294	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:-1(in vitro)|taxid:-1(In vitro)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-9845001|imex:IM-23294-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0680"(single stranded deoxyribonucleic acid)	refseq:NP_003914.1|ensembl:ENSG00000160973(gene)|ensembl:ENST00000377317(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001947"(heart looping)|go:"GO:0003139"(secondary heart field specification)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0003215"(cardiac right ventricle morphogenesis)|go:"GO:0003222"(ventricular trabecula myocardium morphogenesis)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0032444"(activin responsive factor complex)|go:"GO:0033147"(negative regulation of intracellular estrogen receptor signaling pathway)|go:"GO:0035054"(embryonic heart tube anterior/posterior pattern specification)|go:"GO:0035909"(aorta morphogenesis)|go:"GO:0043425"(bHLH transcription factor binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046332"(SMAD binding)|go:"GO:0048318"(axial mesoderm development)|go:"GO:0050681"(androgen receptor binding)|go:"GO:0060766"(negative regulation of androgen receptor signaling pathway)|go:"GO:0070410"(co-SMAD binding)|go:"GO:0070412"(R-SMAD binding)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:1900164"(nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry)|interpro:IPR001766(Fork head transcription factor)|interpro:IPR030456|interpro:IPR036388|interpro:IPR036390|rcsb pdb:5XOC|reactome:R-HSA-1181150|reactome:R-HSA-1502540	pubmed:9702198(primary-reference)	-	-	-	figure legend:Fig. 4D|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/10/13	2014/11/17	rogid:uZzViiPJyxYi9PHrgIEN/ZBW5tI9606	-	intact-crc:E3AB1A033DBE3AE5	false	glutathione s tranferase tag:n-n	32p radiolabel:?-?	-	-	psi-mi:"MI:0833"(autoradiography)	psi-mi:"MI:0833"(autoradiography)