#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q62925	uniprotkb:P62837	intact:EBI-636664	intact:EBI-347677|uniprotkb:P51669|uniprotkb:Q3MN78|uniprotkb:D3DQC9|uniprotkb:Q96RP6|ensembl:ENSP00000381717|ensembl:ENSP00000381718	psi-mi:m3k1_rat(display_long)|uniprotkb:MAPK/ERK kinase kinase 1(gene name synonym)|uniprotkb:Map3k1(gene name)|psi-mi:Map3k1(display_short)|uniprotkb:Mekk(gene name synonym)|uniprotkb:Mekk1(gene name synonym)	psi-mi:ub2d2_human(display_long)|uniprotkb:UBC5B(gene name synonym)|uniprotkb:UBCH4(gene name synonym)|uniprotkb:UBE2D2(gene name)|psi-mi:UBE2D2(display_short)|uniprotkb:UBC4(gene name synonym)|uniprotkb:UBCH5B(gene name synonym)|uniprotkb:Ubiquitin-protein ligase D2(gene name synonym)|uniprotkb:Ubiquitin carrier protein D2(gene name synonym)|uniprotkb:Ubiquitin-conjugating enzyme E2-17 kDa 2(gene name synonym)|uniprotkb:"Ubiquitin-conjugating enzyme E2(17)KB 2"(gene name synonym)|uniprotkb:PUBC1(gene name synonym)|uniprotkb:p53-regulated ubiquitin-conjugating enzyme 1(gene name synonym)|uniprotkb:"(E3-independent) E2 ubiquitin-conjugating enzyme D2"(gene name synonym)|uniprotkb:E2 ubiquitin-conjugating enzyme D2(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9691342|imex:IM-22822-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0898"(putative self)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:620966|refseq:NP_446339.1|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR007527(Zinc finger, SWIM-type)|go:"GO:0000165"(MAPK cascade)|interpro:IPR016024(Armadillo-type fold)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0002011"(morphogenesis of an epithelial sheet)|go:"GO:0003382"(epithelial cell morphogenesis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004706"(JUN kinase kinase kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007254"(JNK cascade)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008432"(JUN kinase binding)|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0016020"(membrane)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0031434"(mitogen-activated protein kinase kinase binding)|go:"GO:0031941"(filamentous actin)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0042060"(wound healing)|go:"GO:0043010"(camera-type eye development)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046625"(sphingolipid binding)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050434"(positive regulation of viral transcription)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0061029"(eyelid development in camera-type eye)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|reactome:R-RNO-166058|reactome:R-RNO-2871796|reactome:R-RNO-975138|reactome:R-RNO-975871|interpro:IPR011989(Armadillo-like helical)|mint:Q62925	refseq:NP_003330.1|refseq:NP_862821.1|dip:DIP-29267N|ensembl:ENSG00000131508(gene)|ensembl:ENST00000398733(transcript)|ensembl:ENST00000398734(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006464"(cellular protein modification process)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0032991"(protein-containing complex)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0061631"(ubiquitin conjugating enzyme activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070936"(protein K48-linked ubiquitination)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|interpro:IPR023313|mint:P62837|rcsb pdb:1UR6|rcsb pdb:1W4U|rcsb pdb:2CLW|rcsb pdb:2ESK|rcsb pdb:2ESO|rcsb pdb:2ESP|rcsb pdb:2ESQ|rcsb pdb:3A33|rcsb pdb:3JVZ|rcsb pdb:3JW0|rcsb pdb:3L1Y|rcsb pdb:3TGD|rcsb pdb:3ZNI|rcsb pdb:4A49|rcsb pdb:4A4B|rcsb pdb:4A4C|rcsb pdb:4AUQ|rcsb pdb:4DDG|rcsb pdb:4DDI|rcsb pdb:4LDT|rcsb pdb:4V3K|rcsb pdb:4V3L|rcsb pdb:4WZ3|rcsb pdb:5D0K|rcsb pdb:5D0M|rcsb pdb:5D1K|rcsb pdb:5D1L|rcsb pdb:5D1M|rcsb pdb:5EDV|rcsb pdb:5MNJ|rcsb pdb:5ULF|rcsb pdb:5ULH|rcsb pdb:5ULK|rcsb pdb:5VZW|rcsb pdb:5ZBU|rcsb pdb:6HPR|rcsb pdb:6M2C|rcsb pdb:6SQO|rcsb pdb:6SQR|rcsb pdb:6SQS|rcsb pdb:6TTU|rcsb pdb:6W7Z|rcsb pdb:6W9D|rcsb pdb:7AI0|rcsb pdb:7AI1|rcsb pdb:7BOL|reactome:R-HSA-1234176|reactome:R-HSA-168927|reactome:R-HSA-202424|reactome:R-HSA-2871837|reactome:R-HSA-5607764|reactome:R-HSA-8866652|reactome:R-HSA-8866654|reactome:R-HSA-8951664|reactome:R-HSA-9033241|reactome:R-HSA-936440|reactome:R-HSA-937041|reactome:R-HSA-9705462|reactome:R-HSA-983168	go:"GO:0051865"(protein autoubiquitination)|go:"GO:0004842"(ubiquitin-protein transferase activity)	-	-	figure legend:S1b, S1c|resulting-ptm:Q62925 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/12/09	rogid:EwhjYjowkZIAt4UyPcZBUtf9uak10116	rogid:vVGrEi0osU/WG0Y9qRCFMT4lgvg9606	intact-crc:80B14AF26B26AEF9|rigid:NQCDFk+DN7QZgoUYfTJgcRDT3RI	false	sufficient binding region:433-481(IPR013083)	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q62925	uniprotkb:P22314	intact:EBI-636664	intact:EBI-709688|uniprotkb:Q96E13|uniprotkb:Q5JRR8|ensembl:ENSP00000338413|ensembl:ENSP00000366568	psi-mi:m3k1_rat(display_long)|uniprotkb:MAPK/ERK kinase kinase 1(gene name synonym)|uniprotkb:Map3k1(gene name)|psi-mi:Map3k1(display_short)|uniprotkb:Mekk(gene name synonym)|uniprotkb:Mekk1(gene name synonym)	psi-mi:uba1_human(display_long)|uniprotkb:Ubiquitin-activating enzyme E1(gene name synonym)|uniprotkb:Protein A1S9(gene name synonym)|uniprotkb:UBA1(gene name)|psi-mi:UBA1(display_short)|uniprotkb:A1S9T(gene name synonym)|uniprotkb:UBE1(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9691342|imex:IM-22822-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0898"(putative self)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:620966|refseq:NP_446339.1|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR007527(Zinc finger, SWIM-type)|go:"GO:0000165"(MAPK cascade)|interpro:IPR016024(Armadillo-type fold)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0002011"(morphogenesis of an epithelial sheet)|go:"GO:0003382"(epithelial cell morphogenesis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004706"(JUN kinase kinase kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007254"(JNK cascade)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008432"(JUN kinase binding)|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0016020"(membrane)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0031434"(mitogen-activated protein kinase kinase binding)|go:"GO:0031941"(filamentous actin)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0042060"(wound healing)|go:"GO:0043010"(camera-type eye development)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046625"(sphingolipid binding)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050434"(positive regulation of viral transcription)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0061029"(eyelid development in camera-type eye)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|reactome:R-RNO-166058|reactome:R-RNO-2871796|reactome:R-RNO-975138|reactome:R-RNO-975871|interpro:IPR011989(Armadillo-like helical)|mint:Q62925	refseq:NP_003325.2|refseq:NP_695012.1|refseq:XP_016885269.1|refseq:XP_016885270.1|dip:DIP-33686N|ensembl:ENSG00000130985(gene)|ensembl:ENST00000335972(transcript)|ensembl:ENST00000377351(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0004839"(ubiquitin activating enzyme activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0032446"(protein modification by small protein conjugation)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000011(Ubiquitin-activating enzyme, E1)|interpro:IPR000594(UBA/THIF-type NAD/FAD binding fold)|interpro:IPR018074|interpro:IPR018075|interpro:IPR018965|interpro:IPR019572|interpro:IPR032418|interpro:IPR032420|interpro:IPR033127|interpro:IPR035985|interpro:IPR038252|interpro:IPR042063|interpro:IPR042302|interpro:IPR042449|mint:P22314|rcsb pdb:4P22|rcsb pdb:6DC6|reactome:R-HSA-8866652|reactome:R-HSA-983168	go:"GO:0051865"(protein autoubiquitination)|go:"GO:0004842"(ubiquitin-protein transferase activity)	-	-	figure legend:S1b, S1c|resulting-ptm:Q62925 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/12/09	rogid:EwhjYjowkZIAt4UyPcZBUtf9uak10116	rogid:q+vEeA0XLST0Zz173bmEt0dNbDE9606	intact-crc:80B14AF26B26AEF9|rigid:NQCDFk+DN7QZgoUYfTJgcRDT3RI	false	sufficient binding region:433-481(IPR013083)	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q62925	uniprotkb:Q9Y385	intact:EBI-636664	intact:EBI-988826|uniprotkb:Q5W0N4|uniprotkb:Q9BZ32|uniprotkb:Q9NQL3|uniprotkb:Q9NY66|uniprotkb:Q9P011|uniprotkb:Q9P0S0|uniprotkb:Q9UF10|ensembl:ENSP00000451261|uniprotkb:A8K3F9|uniprotkb:Q53F25	psi-mi:m3k1_rat(display_long)|uniprotkb:MAPK/ERK kinase kinase 1(gene name synonym)|uniprotkb:Map3k1(gene name)|psi-mi:Map3k1(display_short)|uniprotkb:Mekk(gene name synonym)|uniprotkb:Mekk1(gene name synonym)	psi-mi:ub2j1_human(display_long)|uniprotkb:Non-canonical ubiquitin-conjugating enzyme 1(gene name synonym)|uniprotkb:Yeast ubiquitin-conjugating enzyme UBC6 homolog E(gene name synonym)|uniprotkb:UBE2J1(gene name)|psi-mi:UBE2J1(display_short)|uniprotkb:NCUBE1(gene name synonym)|uniprotkb:CGI-76(orf name)|uniprotkb:HSPC153(orf name)|uniprotkb:HSPC205(orf name)|uniprotkb:E2 ubiquitin-conjugating enzyme J1(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9691320|imex:IM-22822-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0898"(putative self)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:620966|refseq:NP_446339.1|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR007527(Zinc finger, SWIM-type)|go:"GO:0000165"(MAPK cascade)|interpro:IPR016024(Armadillo-type fold)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0002011"(morphogenesis of an epithelial sheet)|go:"GO:0003382"(epithelial cell morphogenesis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004706"(JUN kinase kinase kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007254"(JNK cascade)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008432"(JUN kinase binding)|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0016020"(membrane)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0031434"(mitogen-activated protein kinase kinase binding)|go:"GO:0031941"(filamentous actin)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0042060"(wound healing)|go:"GO:0043010"(camera-type eye development)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046625"(sphingolipid binding)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050434"(positive regulation of viral transcription)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0061029"(eyelid development in camera-type eye)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|reactome:R-RNO-166058|reactome:R-RNO-2871796|reactome:R-RNO-975138|reactome:R-RNO-975871|interpro:IPR011989(Armadillo-like helical)|mint:Q62925	go:"GO:0032680"(regulation of tumor necrosis factor production)|go:"GO:0061631"(ubiquitin conjugating enzyme activity)|go:"GO:1904153"(negative regulation of retrograde protein transport, ER to cytosol)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|reactome:R-HSA-983168|ensembl:ENSG00000198833(gene)|ensembl:ENST00000435041(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0007286"(spermatid development)|go:"GO:0016021"(integral component of membrane)|go:"GO:0018279"(protein N-linked glycosylation via asparagine)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0031625"(ubiquitin protein ligase binding)|refseq:NP_057105.2|dip:DIP-45598N	go:"GO:0051865"(protein autoubiquitination)|go:"GO:0004842"(ubiquitin-protein transferase activity)	-	-	figure legend:S1b|resulting-ptm:Q62925 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/12/09	rogid:EwhjYjowkZIAt4UyPcZBUtf9uak10116	rogid:nc3+V3Qxy1ZDhTWgTPLakJukxPM9606	intact-crc:4BBD53AE3E110CE0|rigid:INzFyOFjajS+ByiUQHW2SzA4uQo	false	sufficient binding region:433-481(IPR013083)	sufficient binding region:2-282|his tag:n-n	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q62925	uniprotkb:P22314	intact:EBI-636664	intact:EBI-709688|uniprotkb:Q96E13|uniprotkb:Q5JRR8|ensembl:ENSP00000338413|ensembl:ENSP00000366568	psi-mi:m3k1_rat(display_long)|uniprotkb:MAPK/ERK kinase kinase 1(gene name synonym)|uniprotkb:Map3k1(gene name)|psi-mi:Map3k1(display_short)|uniprotkb:Mekk(gene name synonym)|uniprotkb:Mekk1(gene name synonym)	psi-mi:uba1_human(display_long)|uniprotkb:Ubiquitin-activating enzyme E1(gene name synonym)|uniprotkb:Protein A1S9(gene name synonym)|uniprotkb:UBA1(gene name)|psi-mi:UBA1(display_short)|uniprotkb:A1S9T(gene name synonym)|uniprotkb:UBE1(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9691320|imex:IM-22822-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0898"(putative self)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:620966|refseq:NP_446339.1|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR007527(Zinc finger, SWIM-type)|go:"GO:0000165"(MAPK cascade)|interpro:IPR016024(Armadillo-type fold)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0002011"(morphogenesis of an epithelial sheet)|go:"GO:0003382"(epithelial cell morphogenesis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004706"(JUN kinase kinase kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007254"(JNK cascade)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008432"(JUN kinase binding)|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0016020"(membrane)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0031434"(mitogen-activated protein kinase kinase binding)|go:"GO:0031941"(filamentous actin)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0042060"(wound healing)|go:"GO:0043010"(camera-type eye development)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046625"(sphingolipid binding)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050434"(positive regulation of viral transcription)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0061029"(eyelid development in camera-type eye)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|reactome:R-RNO-166058|reactome:R-RNO-2871796|reactome:R-RNO-975138|reactome:R-RNO-975871|interpro:IPR011989(Armadillo-like helical)|mint:Q62925	refseq:NP_003325.2|refseq:NP_695012.1|refseq:XP_016885269.1|refseq:XP_016885270.1|dip:DIP-33686N|ensembl:ENSG00000130985(gene)|ensembl:ENST00000335972(transcript)|ensembl:ENST00000377351(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0004839"(ubiquitin activating enzyme activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0032446"(protein modification by small protein conjugation)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000011(Ubiquitin-activating enzyme, E1)|interpro:IPR000594(UBA/THIF-type NAD/FAD binding fold)|interpro:IPR018074|interpro:IPR018075|interpro:IPR018965|interpro:IPR019572|interpro:IPR032418|interpro:IPR032420|interpro:IPR033127|interpro:IPR035985|interpro:IPR038252|interpro:IPR042063|interpro:IPR042302|interpro:IPR042449|mint:P22314|rcsb pdb:4P22|rcsb pdb:6DC6|reactome:R-HSA-8866652|reactome:R-HSA-983168	go:"GO:0051865"(protein autoubiquitination)|go:"GO:0004842"(ubiquitin-protein transferase activity)	-	-	figure legend:S1b|resulting-ptm:Q62925 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/12/09	rogid:EwhjYjowkZIAt4UyPcZBUtf9uak10116	rogid:q+vEeA0XLST0Zz173bmEt0dNbDE9606	intact-crc:4BBD53AE3E110CE0|rigid:INzFyOFjajS+ByiUQHW2SzA4uQo	false	sufficient binding region:433-481(IPR013083)	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q62925	uniprotkb:P61077	intact:EBI-636664	intact:EBI-348268|ensembl:ENSP00000318494|ensembl:ENSP00000337208|ensembl:ENSP00000378283|ensembl:ENSP00000396901|ensembl:ENSP00000344069|ensembl:ENSP00000378280|ensembl:ENSP00000378282|uniprotkb:A6NM99|intact:EBI-2809412|uniprotkb:P47986|uniprotkb:Q6IB88|uniprotkb:Q6NXS4|uniprotkb:Q8N924|uniprotkb:A6NJ93|uniprotkb:A6NJB1	psi-mi:m3k1_rat(display_long)|uniprotkb:MAPK/ERK kinase kinase 1(gene name synonym)|uniprotkb:Map3k1(gene name)|psi-mi:Map3k1(display_short)|uniprotkb:Mekk(gene name synonym)|uniprotkb:Mekk1(gene name synonym)	psi-mi:ub2d3_human(display_long)|uniprotkb:UBC5C(gene name synonym)|uniprotkb:Ubiquitin-protein ligase D3(gene name synonym)|uniprotkb:Ubiquitin carrier protein D3(gene name synonym)|uniprotkb:Ubiquitin-conjugating enzyme E2-17 kDa 3(gene name synonym)|uniprotkb:"Ubiquitin-conjugating enzyme E2(17)KB 3"(gene name synonym)|uniprotkb:UBE2D3(gene name)|psi-mi:UBE2D3(display_short)|uniprotkb:UBCH5C(gene name synonym)|uniprotkb:"(E3-independent) E2 ubiquitin-conjugating enzyme D3"(gene name synonym)|uniprotkb:E2 ubiquitin-conjugating enzyme D3(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9691308|imex:IM-22822-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0898"(putative self)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:620966|refseq:NP_446339.1|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR007527(Zinc finger, SWIM-type)|go:"GO:0000165"(MAPK cascade)|interpro:IPR016024(Armadillo-type fold)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0002011"(morphogenesis of an epithelial sheet)|go:"GO:0003382"(epithelial cell morphogenesis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004706"(JUN kinase kinase kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007254"(JNK cascade)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008432"(JUN kinase binding)|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0016020"(membrane)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0031434"(mitogen-activated protein kinase kinase binding)|go:"GO:0031941"(filamentous actin)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0042060"(wound healing)|go:"GO:0043010"(camera-type eye development)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046625"(sphingolipid binding)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050434"(positive regulation of viral transcription)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0061029"(eyelid development in camera-type eye)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|reactome:R-RNO-166058|reactome:R-RNO-2871796|reactome:R-RNO-975138|reactome:R-RNO-975871|interpro:IPR011989(Armadillo-like helical)|mint:Q62925	ensembl:ENSG00000109332(gene)|ensembl:ENST00000321805(transcript)|ensembl:ENST00000338145(transcript)|ensembl:ENST00000349311(transcript)|ensembl:ENST00000394801(transcript)|ensembl:ENST00000394803(transcript)|ensembl:ENST00000394804(transcript)|ensembl:ENST00000453744(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006281"(DNA repair)|go:"GO:0006513"(protein monoubiquitination)|go:"GO:0006915"(apoptotic process)|go:"GO:0010008"(endosome membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0006464"(cellular protein modification process)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0061631"(ubiquitin conjugating enzyme activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070936"(protein K48-linked ubiquitination)|go:"GO:0070979"(protein K11-linked ubiquitination)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0071288"(cellular response to mercury ion)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|interpro:IPR023313|rcsb pdb:2FUH|rcsb pdb:3L1Z|rcsb pdb:3RPG|rcsb pdb:3UGB|rcsb pdb:4BVU|rcsb pdb:4R8P|rcsb pdb:4S3O|rcsb pdb:5EGG|rcsb pdb:5IFR|rcsb pdb:6CP0|rcsb pdb:6T7F|rcsb pdb:7JZV|reactome:R-HSA-1234176|reactome:R-HSA-168927|reactome:R-HSA-201451|reactome:R-HSA-2173795|reactome:R-HSA-8866654|reactome:R-HSA-8951664|reactome:R-HSA-9033241|reactome:R-HSA-936440|reactome:R-HSA-937041|reactome:R-HSA-9705462|reactome:R-HSA-983168|rcsb pdb:1X23|refseq:NP_003331.1|refseq:NP_871615.1|refseq:NP_871616.1|refseq:NP_871617.1|refseq:NP_871618.1|refseq:NP_871619.1|refseq:NP_871620.1|refseq:NP_871621.1|refseq:NP_871622.1|dip:DIP-29062N	go:"GO:0051865"(protein autoubiquitination)|go:"GO:0004842"(ubiquitin-protein transferase activity)	-	-	figure legend:S1b, S1c|resulting-ptm:Q62925 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/12/09	rogid:EwhjYjowkZIAt4UyPcZBUtf9uak10116	rogid:jSQ4I+Cgli7HaN5S0OLUP+J5YXs9606	intact-crc:3BC33F2256311355|rigid:2T0+b9tVbQODl5SQZ2aBV6ceZ8I	false	sufficient binding region:433-481(IPR013083)	glutathione s tranferase tag:n-n	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q62925	uniprotkb:P22314	intact:EBI-636664	intact:EBI-709688|uniprotkb:Q96E13|uniprotkb:Q5JRR8|ensembl:ENSP00000338413|ensembl:ENSP00000366568	psi-mi:m3k1_rat(display_long)|uniprotkb:MAPK/ERK kinase kinase 1(gene name synonym)|uniprotkb:Map3k1(gene name)|psi-mi:Map3k1(display_short)|uniprotkb:Mekk(gene name synonym)|uniprotkb:Mekk1(gene name synonym)	psi-mi:uba1_human(display_long)|uniprotkb:Ubiquitin-activating enzyme E1(gene name synonym)|uniprotkb:Protein A1S9(gene name synonym)|uniprotkb:UBA1(gene name)|psi-mi:UBA1(display_short)|uniprotkb:A1S9T(gene name synonym)|uniprotkb:UBE1(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9691308|imex:IM-22822-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0898"(putative self)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:620966|refseq:NP_446339.1|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR007527(Zinc finger, SWIM-type)|go:"GO:0000165"(MAPK cascade)|interpro:IPR016024(Armadillo-type fold)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0002011"(morphogenesis of an epithelial sheet)|go:"GO:0003382"(epithelial cell morphogenesis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004706"(JUN kinase kinase kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007254"(JNK cascade)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008432"(JUN kinase binding)|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0016020"(membrane)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0031434"(mitogen-activated protein kinase kinase binding)|go:"GO:0031941"(filamentous actin)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0042060"(wound healing)|go:"GO:0043010"(camera-type eye development)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046625"(sphingolipid binding)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050434"(positive regulation of viral transcription)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0061029"(eyelid development in camera-type eye)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|reactome:R-RNO-166058|reactome:R-RNO-2871796|reactome:R-RNO-975138|reactome:R-RNO-975871|interpro:IPR011989(Armadillo-like helical)|mint:Q62925	refseq:NP_003325.2|refseq:NP_695012.1|refseq:XP_016885269.1|refseq:XP_016885270.1|dip:DIP-33686N|ensembl:ENSG00000130985(gene)|ensembl:ENST00000335972(transcript)|ensembl:ENST00000377351(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0004839"(ubiquitin activating enzyme activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0032446"(protein modification by small protein conjugation)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000011(Ubiquitin-activating enzyme, E1)|interpro:IPR000594(UBA/THIF-type NAD/FAD binding fold)|interpro:IPR018074|interpro:IPR018075|interpro:IPR018965|interpro:IPR019572|interpro:IPR032418|interpro:IPR032420|interpro:IPR033127|interpro:IPR035985|interpro:IPR038252|interpro:IPR042063|interpro:IPR042302|interpro:IPR042449|mint:P22314|rcsb pdb:4P22|rcsb pdb:6DC6|reactome:R-HSA-8866652|reactome:R-HSA-983168	go:"GO:0051865"(protein autoubiquitination)|go:"GO:0004842"(ubiquitin-protein transferase activity)	-	-	figure legend:S1b, S1c|resulting-ptm:Q62925 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/12/09	rogid:EwhjYjowkZIAt4UyPcZBUtf9uak10116	rogid:q+vEeA0XLST0Zz173bmEt0dNbDE9606	intact-crc:3BC33F2256311355|rigid:2T0+b9tVbQODl5SQZ2aBV6ceZ8I	false	sufficient binding region:433-481(IPR013083)	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q62925	uniprotkb:Q13404	intact:EBI-636664	intact:EBI-1050671|uniprotkb:Q13403|uniprotkb:Q13532|uniprotkb:Q96H34|uniprotkb:Q9GZT0|uniprotkb:Q9GZW1|uniprotkb:Q9H4J3|uniprotkb:Q9H4J4|uniprotkb:Q9UKL1|uniprotkb:Q9UM48|uniprotkb:Q9UM49|uniprotkb:Q9UM50|uniprotkb:Q5TGE3|uniprotkb:E1P629|uniprotkb:Q5TGE0|ensembl:ENSP00000360739	psi-mi:m3k1_rat(display_long)|uniprotkb:MAPK/ERK kinase kinase 1(gene name synonym)|uniprotkb:Map3k1(gene name)|psi-mi:Map3k1(display_short)|uniprotkb:Mekk(gene name synonym)|uniprotkb:Mekk1(gene name synonym)	psi-mi:ub2v1_human(display_long)|uniprotkb:CROC-1(gene name synonym)|uniprotkb:TRAF6-regulated IKK activator 1 beta Uev1A(gene name synonym)|uniprotkb:P/OKcl.19(orf name)|uniprotkb:UBE2V1(gene name)|psi-mi:UBE2V1(display_short)|uniprotkb:CROC1(gene name synonym)|uniprotkb:UBE2V(gene name synonym)|uniprotkb:UEV1(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9691331|imex:IM-22822-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0898"(putative self)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:620966|refseq:NP_446339.1|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR007527(Zinc finger, SWIM-type)|go:"GO:0000165"(MAPK cascade)|interpro:IPR016024(Armadillo-type fold)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0002011"(morphogenesis of an epithelial sheet)|go:"GO:0003382"(epithelial cell morphogenesis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004706"(JUN kinase kinase kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007254"(JNK cascade)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008432"(JUN kinase binding)|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0016020"(membrane)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0031434"(mitogen-activated protein kinase kinase binding)|go:"GO:0031941"(filamentous actin)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0042060"(wound healing)|go:"GO:0043010"(camera-type eye development)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046625"(sphingolipid binding)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050434"(positive regulation of viral transcription)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0061029"(eyelid development in camera-type eye)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|reactome:R-RNO-166058|reactome:R-RNO-2871796|reactome:R-RNO-975138|reactome:R-RNO-975871|interpro:IPR011989(Armadillo-like helical)|mint:Q62925	refseq:NP_001027459.1|refseq:NP_068823.2|refseq:NP_071887.1|refseq:NP_954595.1|refseq:NP_954673.1|refseq:NP_001244322.1|refseq:NP_001244323.1|refseq:NP_001244325.1|ensembl:ENSG00000244687(gene)|ensembl:ENST00000371674(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006282"(regulation of DNA repair)|go:"GO:0006301"(postreplication repair)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0030154"(cell differentiation)|go:"GO:0031371"(ubiquitin conjugating enzyme complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035370"(UBC13-UEV1A complex)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070534"(protein K63-linked ubiquitination)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|rcsb pdb:2A4D|rcsb pdb:2C2V|rcsb pdb:2HLW|rcsb pdb:6D6I|reactome:R-HSA-168638|reactome:R-HSA-168927|reactome:R-HSA-202424|reactome:R-HSA-2871837|reactome:R-HSA-445989|reactome:R-HSA-450302|reactome:R-HSA-450321|reactome:R-HSA-5607764|reactome:R-HSA-9020702|reactome:R-HSA-937039|reactome:R-HSA-937041|reactome:R-HSA-9646399|reactome:R-HSA-975110|reactome:R-HSA-975144|reactome:R-HSA-983168|dip:DIP-41911N	go:"GO:0051865"(protein autoubiquitination)|go:"GO:0004842"(ubiquitin-protein transferase activity)	-	-	figure legend:S1b, S1c, S3b, S3c, S3d, S3e, S3f|agonist:TAB1, TNIP1, TNIP2, TRAF2, STAM1.|resulting-ptm:Q62925 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/12/09	rogid:EwhjYjowkZIAt4UyPcZBUtf9uak10116	rogid:x95N7Dj2KIqu5gySX59xLmfthUg9606	intact-crc:330BDA031DD31606|rigid:7NavsnSZbqlAXRAYtUFEf3bdsII	false	mutation disrupting interaction:438-438,440-440|sufficient binding region:433-481(IPR013083)	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q62925	uniprotkb:P22314	intact:EBI-636664	intact:EBI-709688|uniprotkb:Q96E13|uniprotkb:Q5JRR8|ensembl:ENSP00000338413|ensembl:ENSP00000366568	psi-mi:m3k1_rat(display_long)|uniprotkb:MAPK/ERK kinase kinase 1(gene name synonym)|uniprotkb:Map3k1(gene name)|psi-mi:Map3k1(display_short)|uniprotkb:Mekk(gene name synonym)|uniprotkb:Mekk1(gene name synonym)	psi-mi:uba1_human(display_long)|uniprotkb:Ubiquitin-activating enzyme E1(gene name synonym)|uniprotkb:Protein A1S9(gene name synonym)|uniprotkb:UBA1(gene name)|psi-mi:UBA1(display_short)|uniprotkb:A1S9T(gene name synonym)|uniprotkb:UBE1(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9691331|imex:IM-22822-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0898"(putative self)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:620966|refseq:NP_446339.1|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR007527(Zinc finger, SWIM-type)|go:"GO:0000165"(MAPK cascade)|interpro:IPR016024(Armadillo-type fold)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0002011"(morphogenesis of an epithelial sheet)|go:"GO:0003382"(epithelial cell morphogenesis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004706"(JUN kinase kinase kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007254"(JNK cascade)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008432"(JUN kinase binding)|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0016020"(membrane)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0031434"(mitogen-activated protein kinase kinase binding)|go:"GO:0031941"(filamentous actin)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0042060"(wound healing)|go:"GO:0043010"(camera-type eye development)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046625"(sphingolipid binding)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050434"(positive regulation of viral transcription)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0061029"(eyelid development in camera-type eye)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|reactome:R-RNO-166058|reactome:R-RNO-2871796|reactome:R-RNO-975138|reactome:R-RNO-975871|interpro:IPR011989(Armadillo-like helical)|mint:Q62925	refseq:NP_003325.2|refseq:NP_695012.1|refseq:XP_016885269.1|refseq:XP_016885270.1|dip:DIP-33686N|ensembl:ENSG00000130985(gene)|ensembl:ENST00000335972(transcript)|ensembl:ENST00000377351(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0004839"(ubiquitin activating enzyme activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0032446"(protein modification by small protein conjugation)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000011(Ubiquitin-activating enzyme, E1)|interpro:IPR000594(UBA/THIF-type NAD/FAD binding fold)|interpro:IPR018074|interpro:IPR018075|interpro:IPR018965|interpro:IPR019572|interpro:IPR032418|interpro:IPR032420|interpro:IPR033127|interpro:IPR035985|interpro:IPR038252|interpro:IPR042063|interpro:IPR042302|interpro:IPR042449|mint:P22314|rcsb pdb:4P22|rcsb pdb:6DC6|reactome:R-HSA-8866652|reactome:R-HSA-983168	go:"GO:0051865"(protein autoubiquitination)|go:"GO:0004842"(ubiquitin-protein transferase activity)	-	-	figure legend:S1b, S1c, S3b, S3c, S3d, S3e, S3f|agonist:TAB1, TNIP1, TNIP2, TRAF2, STAM1.|resulting-ptm:Q62925 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/12/09	rogid:EwhjYjowkZIAt4UyPcZBUtf9uak10116	rogid:q+vEeA0XLST0Zz173bmEt0dNbDE9606	intact-crc:330BDA031DD31606|rigid:7NavsnSZbqlAXRAYtUFEf3bdsII	false	mutation disrupting interaction:438-438,440-440|sufficient binding region:433-481(IPR013083)	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q62925	uniprotkb:P61088	intact:EBI-636664	intact:EBI-1052908|uniprotkb:Q16781|uniprotkb:Q53Y81|ensembl:ENSP00000316176	psi-mi:m3k1_rat(display_long)|uniprotkb:MAPK/ERK kinase kinase 1(gene name synonym)|uniprotkb:Map3k1(gene name)|psi-mi:Map3k1(display_short)|uniprotkb:Mekk(gene name synonym)|uniprotkb:Mekk1(gene name synonym)	psi-mi:ube2n_human(display_long)|uniprotkb:Ubiquitin-protein ligase N(gene name synonym)|uniprotkb:Ubiquitin carrier protein N(gene name synonym)|uniprotkb:Ubc13(gene name synonym)|uniprotkb:Bendless-like ubiquitin-conjugating enzyme(gene name synonym)|uniprotkb:UBE2N(gene name)|psi-mi:UBE2N(display_short)|uniprotkb:BLU(gene name synonym)|uniprotkb:UbcH13(gene name synonym)|uniprotkb:E2 ubiquitin-conjugating enzyme N(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9691331|imex:IM-22822-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0898"(putative self)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:620966|refseq:NP_446339.1|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR007527(Zinc finger, SWIM-type)|go:"GO:0000165"(MAPK cascade)|interpro:IPR016024(Armadillo-type fold)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0002011"(morphogenesis of an epithelial sheet)|go:"GO:0003382"(epithelial cell morphogenesis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004706"(JUN kinase kinase kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007254"(JNK cascade)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008432"(JUN kinase binding)|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0016020"(membrane)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0031434"(mitogen-activated protein kinase kinase binding)|go:"GO:0031941"(filamentous actin)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0042060"(wound healing)|go:"GO:0043010"(camera-type eye development)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046625"(sphingolipid binding)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050434"(positive regulation of viral transcription)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0061029"(eyelid development in camera-type eye)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|reactome:R-RNO-166058|reactome:R-RNO-2871796|reactome:R-RNO-975138|reactome:R-RNO-975871|interpro:IPR011989(Armadillo-like helical)|mint:Q62925	refseq:NP_003339.1|dip:DIP-29829N|ensembl:ENSG00000177889(gene)|ensembl:ENST00000318066(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000729"(DNA double-strand break processing)|go:"GO:0001650"(fibrillar center)|go:"GO:0003723"(RNA binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006282"(regulation of DNA repair)|go:"GO:0006301"(postreplication repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016574"(histone ubiquitination)|go:"GO:0031058"(positive regulation of histone modification)|go:"GO:0031372"(UBC13-MMS2 complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033182"(regulation of histone ubiquitination)|go:"GO:0035370"(UBC13-UEV1A complex)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0061631"(ubiquitin conjugating enzyme activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070534"(protein K63-linked ubiquitination)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|interpro:IPR023313|rcsb pdb:1J7D|rcsb pdb:2C2V|rcsb pdb:3HCT|rcsb pdb:3HCU|rcsb pdb:3VON|rcsb pdb:3W31|rcsb pdb:4DHI|rcsb pdb:4DHJ|rcsb pdb:4DHZ|rcsb pdb:4IP3|rcsb pdb:4NR3|rcsb pdb:4NRG|rcsb pdb:4NRI|rcsb pdb:4ONL|rcsb pdb:4ONM|rcsb pdb:4ONN|rcsb pdb:4ORH|rcsb pdb:4TKP|rcsb pdb:4WHV|rcsb pdb:5AIT|rcsb pdb:5AIU|rcsb pdb:5EYA|rcsb pdb:5H7S|rcsb pdb:5VNZ|rcsb pdb:5VO0|rcsb pdb:5YWR|rcsb pdb:6D6I|rcsb pdb:6JKY|rcsb pdb:6KFP|rcsb pdb:6KG6|rcsb pdb:6KL4|rcsb pdb:6LP2|rcsb pdb:6P5B|rcsb pdb:6S53|reactome:R-HSA-168927|reactome:R-HSA-202424|reactome:R-HSA-2871837|reactome:R-HSA-445989|reactome:R-HSA-450302|reactome:R-HSA-450321|reactome:R-HSA-5607764|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-5696395|reactome:R-HSA-69473|reactome:R-HSA-8866654|reactome:R-HSA-9020702|reactome:R-HSA-937039|reactome:R-HSA-937041|reactome:R-HSA-9646399|reactome:R-HSA-975110|reactome:R-HSA-975144|reactome:R-HSA-983168|rcsb pdb:6ULH|rcsb pdb:6UMP|rcsb pdb:6UMS|rcsb pdb:7BBD|rcsb pdb:7BBF|rcsb pdb:7BXG|reactome:R-HSA-1169408|reactome:R-HSA-168638	go:"GO:0051865"(protein autoubiquitination)|go:"GO:0004842"(ubiquitin-protein transferase activity)	-	-	figure legend:S1b, S1c, S3b, S3c, S3d, S3e, S3f|agonist:TAB1, TNIP1, TNIP2, TRAF2, STAM1.|resulting-ptm:Q62925 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/12/09	rogid:EwhjYjowkZIAt4UyPcZBUtf9uak10116	rogid:dqdszHlq5FLPHC6UWX6uvkC6Yz89606	intact-crc:330BDA031DD31606|rigid:7NavsnSZbqlAXRAYtUFEf3bdsII	false	mutation disrupting interaction:438-438,440-440|sufficient binding region:433-481(IPR013083)	his tag:n-n	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P40818	uniprotkb:Q62925	intact:EBI-1050865|uniprotkb:Q2TB31|uniprotkb:Q7Z3U2|uniprotkb:Q86VA0|uniprotkb:Q8IWI7|ensembl:ENSP00000302239|ensembl:ENSP00000379721|uniprotkb:B4DKA8	intact:EBI-636664	psi-mi:ubp8_human(display_long)|uniprotkb:Ubiquitin-specific-processing protease 8(gene name synonym)|uniprotkb:Deubiquitinating enzyme 8(gene name synonym)|uniprotkb:USP8(gene name)|psi-mi:USP8(display_short)|uniprotkb:KIAA0055(gene name synonym)|uniprotkb:UBPY(gene name synonym)|uniprotkb:Ubiquitin isopeptidase Y(gene name synonym)|uniprotkb:Ubiquitin thioesterase 8(gene name synonym)	psi-mi:m3k1_rat(display_long)|uniprotkb:MAPK/ERK kinase kinase 1(gene name synonym)|uniprotkb:Map3k1(gene name)|psi-mi:Map3k1(display_short)|uniprotkb:Mekk(gene name synonym)|uniprotkb:Mekk1(gene name synonym)	psi-mi:"MI:0998"(deubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0204"(deubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9691508|imex:IM-22822-7	-	-	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001122082.1|refseq:NP_005145.3|refseq:NP_001269978.1|refseq:XP_011520495.1|ensembl:ENSG00000138592(gene)|ensembl:ENST00000307179(transcript)|ensembl:ENST00000396444(transcript)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0007032"(endosome organization)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0030496"(midbody)|go:"GO:0031313"(extrinsic component of endosome membrane)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0043197"(dendritic spine)|go:"GO:0045296"(cadherin binding)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0071108"(protein K48-linked deubiquitination)|go:"GO:0071549"(cellular response to dexamethasone stimulus)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099576"(regulation of protein catabolic process at postsynapse, modulating synaptic transmission)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR001763(Rhodanese-like)|interpro:IPR015063(Region of unknown function DUF1873)|interpro:IPR018200|interpro:IPR028889|interpro:IPR036873|interpro:IPR038765|mint:P40818|rcsb pdb:1WHB|rcsb pdb:2A9U|rcsb pdb:2GFO|rcsb pdb:2GWF|rcsb pdb:3N3K|rcsb pdb:6F09|reactome:R-HSA-1358803|reactome:R-HSA-4641263|reactome:R-HSA-5689880|reactome:R-HSA-6807004|refseq:XP_006720824.1|dip:DIP-40365N	rgd:620966|refseq:NP_446339.1|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR007527(Zinc finger, SWIM-type)|go:"GO:0000165"(MAPK cascade)|interpro:IPR016024(Armadillo-type fold)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0002011"(morphogenesis of an epithelial sheet)|go:"GO:0003382"(epithelial cell morphogenesis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004706"(JUN kinase kinase kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007254"(JNK cascade)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008432"(JUN kinase binding)|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0016020"(membrane)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0031434"(mitogen-activated protein kinase kinase binding)|go:"GO:0031941"(filamentous actin)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0042060"(wound healing)|go:"GO:0043010"(camera-type eye development)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046625"(sphingolipid binding)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050434"(positive regulation of viral transcription)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0061029"(eyelid development in camera-type eye)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|reactome:R-RNO-166058|reactome:R-RNO-2871796|reactome:R-RNO-975138|reactome:R-RNO-975871|interpro:IPR011989(Armadillo-like helical)|mint:Q62925	go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0016579"(protein deubiquitination)	-	-	figure legend:S1d|comment:"UBA1 (P22314) and UBE2N:UBE2V1 (P61088, Q13404) are present in the reaction to get MEKK1 ubiquitinylated before adding the de-ubiquitinase."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:hpBBzyA4lc9is80ZFJBr1fyEyOM9606	rogid:EwhjYjowkZIAt4UyPcZBUtf9uak10116	intact-crc:3FE9C513819F5CBB|rigid:bBm2U+vlHGdpp+53Xtwb8bn0Nm8	false	his tag:n-n	sufficient binding region:433-481(IPR013083)|ubiquitinylated lysine:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q62925	uniprotkb:O75604	intact:EBI-636664	intact:EBI-743272|uniprotkb:Q96MB9|uniprotkb:Q9BQ21|ensembl:ENSP00000260187|uniprotkb:Q8IW04|uniprotkb:Q8IUM2|uniprotkb:B0YJB8|uniprotkb:E9PPM2	psi-mi:m3k1_rat(display_long)|uniprotkb:MAPK/ERK kinase kinase 1(gene name synonym)|uniprotkb:Map3k1(gene name)|psi-mi:Map3k1(display_short)|uniprotkb:Mekk(gene name synonym)|uniprotkb:Mekk1(gene name synonym)	psi-mi:ubp2_human(display_long)|uniprotkb:Ubiquitin-specific-processing protease 2(gene name synonym)|uniprotkb:Deubiquitinating enzyme 2(gene name synonym)|uniprotkb:41 kDa ubiquitin-specific protease(gene name synonym)|uniprotkb:USP2(gene name)|psi-mi:USP2(display_short)|uniprotkb:UBP41(gene name synonym)|uniprotkb:Ubiquitin thioesterase 2(gene name synonym)	psi-mi:"MI:0998"(deubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0204"(deubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9691474|imex:IM-22822-5	-	-	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:620966|refseq:NP_446339.1|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR007527(Zinc finger, SWIM-type)|go:"GO:0000165"(MAPK cascade)|interpro:IPR016024(Armadillo-type fold)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0002011"(morphogenesis of an epithelial sheet)|go:"GO:0003382"(epithelial cell morphogenesis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004706"(JUN kinase kinase kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007254"(JNK cascade)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008432"(JUN kinase binding)|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0016020"(membrane)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0031434"(mitogen-activated protein kinase kinase binding)|go:"GO:0031941"(filamentous actin)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0042060"(wound healing)|go:"GO:0043010"(camera-type eye development)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046625"(sphingolipid binding)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050434"(positive regulation of viral transcription)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0061029"(eyelid development in camera-type eye)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|reactome:R-RNO-166058|reactome:R-RNO-2871796|reactome:R-RNO-975138|reactome:R-RNO-975871|interpro:IPR011989(Armadillo-like helical)|mint:Q62925	refseq:NP_004196.4|refseq:NP_741994.1|ensembl:ENSG00000036672(gene)|ensembl:ENST00000260187(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0007049"(cell cycle)|go:"GO:0007517"(muscle organ development)|go:"GO:0016020"(membrane)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0042802"(identical protein binding)|go:"GO:0043153"(entrainment of circadian clock by photoperiod)|go:"GO:0045475"(locomotor rhythm)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0046872"(metal ion binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048512"(circadian behavior)|go:"GO:0050821"(protein stabilization)|go:"GO:1901796"(regulation of signal transduction by p53 class mediator)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR018200|go:"GO:0030332"(cyclin binding)|interpro:IPR028889|interpro:IPR038765|mint:O75604|rcsb pdb:2HD5|rcsb pdb:2IBI|rcsb pdb:3NHE|rcsb pdb:3V6C|rcsb pdb:3V6E|rcsb pdb:5XU8|rcsb pdb:5XVE|rcsb pdb:6DGF|reactome:R-HSA-5357786|reactome:R-HSA-5357905|reactome:R-HSA-5357956|reactome:R-HSA-5689880|reactome:R-HSA-6804757|refseq:NP_001230688.1|refseq:XP_005271778.1|refseq:XP_005271779.1|dip:DIP-29134N	go:"GO:0016579"(protein deubiquitination)|go:"GO:0004843"(thiol-dependent deubiquitinase)	-	-	figure legend:S1d|comment:"UBA1 (P22314) and UBE2N:UBE2V1 (P61088, Q13404) are present in the reaction to get MEKK1 ubiquitinylated before adding the de-ubiquitinase."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:EwhjYjowkZIAt4UyPcZBUtf9uak10116	rogid:ILcDPhStrk+aUeVZ4y3yR4B/4y49606	intact-crc:325D10BF26051A31|rigid:voBALnVINeEP3gveC+ZvcWmGBH0	false	ubiquitinylated lysine:?-?|sufficient binding region:433-481(IPR013083)	sufficient binding region:259-605(IPR028889)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q62925	uniprotkb:Q93009	intact:EBI-636664	intact:EBI-302474|uniprotkb:A6NMY8|intact:EBI-28988230|ensembl:ENSP00000343535|uniprotkb:B7Z815|uniprotkb:H0Y3G8	psi-mi:m3k1_rat(display_long)|uniprotkb:MAPK/ERK kinase kinase 1(gene name synonym)|uniprotkb:Map3k1(gene name)|psi-mi:Map3k1(display_short)|uniprotkb:Mekk(gene name synonym)|uniprotkb:Mekk1(gene name synonym)	psi-mi:ubp7_human(display_long)|uniprotkb:USP7(gene name)|psi-mi:USP7(display_short)|uniprotkb:HAUSP(gene name synonym)|uniprotkb:Ubiquitin thioesterase 7(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 7(gene name synonym)|uniprotkb:Deubiquitinating enzyme 7(gene name synonym)|uniprotkb:Herpesvirus-associated ubiquitin-specific protease(gene name synonym)	psi-mi:"MI:0998"(deubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0204"(deubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9691490|imex:IM-22822-6	-	-	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:620966|refseq:NP_446339.1|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR007527(Zinc finger, SWIM-type)|go:"GO:0000165"(MAPK cascade)|interpro:IPR016024(Armadillo-type fold)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0002011"(morphogenesis of an epithelial sheet)|go:"GO:0003382"(epithelial cell morphogenesis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004706"(JUN kinase kinase kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007254"(JNK cascade)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008432"(JUN kinase binding)|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0016020"(membrane)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0031434"(mitogen-activated protein kinase kinase binding)|go:"GO:0031941"(filamentous actin)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0042060"(wound healing)|go:"GO:0043010"(camera-type eye development)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046625"(sphingolipid binding)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050434"(positive regulation of viral transcription)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0061029"(eyelid development in camera-type eye)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|reactome:R-RNO-166058|reactome:R-RNO-2871796|reactome:R-RNO-975138|reactome:R-RNO-975871|interpro:IPR011989(Armadillo-like helical)|mint:Q62925	rcsb pdb:4PYZ|rcsb pdb:4WPH|rcsb pdb:4WPI|rcsb pdb:4YOC|rcsb pdb:4YSI|rcsb pdb:4Z96|rcsb pdb:4Z97|rcsb pdb:5C56|rcsb pdb:5C6D|rcsb pdb:5FWI|rcsb pdb:5GG4|rcsb pdb:5J7T|rcsb pdb:5JTJ|rcsb pdb:5JTV|rcsb pdb:5KYB|rcsb pdb:4M5X|rcsb pdb:5KYC|rcsb pdb:5KYD|rcsb pdb:5KYE|rcsb pdb:5KYF|interpro:IPR029346|interpro:IPR038765|mint:Q93009|rcsb pdb:1NB8|rcsb pdb:1NBF|rcsb pdb:1YY6|rcsb pdb:1YZE|rcsb pdb:2F1W|rcsb pdb:2F1X|rcsb pdb:2F1Y|rcsb pdb:2F1Z|rcsb pdb:2FOJ|rcsb pdb:2FOO|rcsb pdb:2FOP|rcsb pdb:2KVR|rcsb pdb:2XXN|rcsb pdb:2YLM|rcsb pdb:3MQR|rcsb pdb:3MQS|rcsb pdb:4JJQ|rcsb pdb:4KG9|rcsb pdb:4M5W|go:"GO:0006283"(transcription-coupled nucleotide-excision repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008134"(transcription factor binding)|go:"GO:0010216"(maintenance of DNA methylation)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0016604"(nuclear body)|go:"GO:0016605"(PML body)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032435"(negative regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035520"(monoubiquitinated protein deubiquitination)|go:"GO:0035616"(histone H2B conserved C-terminal lysine deubiquitination)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0048511"(rhythmic process)|go:"GO:0050821"(protein stabilization)|go:"GO:0051090"(regulation of DNA-binding transcription factor activity)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0101005"(deubiquitinase activity)|go:"GO:1901537"(positive regulation of DNA demethylation)|go:"GO:1901796"(regulation of signal transduction by p53 class mediator)|go:"GO:1904353"(regulation of telomere capping)|go:"GO:1905279"(regulation of retrograde transport, endosome to Golgi)|go:"GO:1990380"(Lys48-specific deubiquitinase activity)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR002083(MATH)|interpro:IPR008974(TRAF-like)|interpro:IPR018200|interpro:IPR024729|interpro:IPR028889|ensembl:ENSG00000187555(gene)|ensembl:ENST00000344836(transcript)|go:"GO:0002039"(p53 binding)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005829"(cytosol)|go:"GO:0006111"(regulation of gluconeogenesis)|rcsb pdb:5N9R|rcsb pdb:5N9T|rcsb pdb:5NGE|rcsb pdb:5NGF|rcsb pdb:5UQV|rcsb pdb:5UQX|rcsb pdb:5VS6|rcsb pdb:5VSB|rcsb pdb:5VSK|rcsb pdb:5WHC|rcsb pdb:6F5H|rcsb pdb:6M1K|rcsb pdb:6P5L|rcsb pdb:6VN2|rcsb pdb:6VN3|rcsb pdb:6VN4|rcsb pdb:6VN5|rcsb pdb:6VN6|rcsb pdb:7CM2|reactome:R-HSA-5689880|reactome:R-HSA-6781823|reactome:R-HSA-6781827|reactome:R-HSA-6782135|reactome:R-HSA-6782210|reactome:R-HSA-6804757|reactome:R-HSA-8866652|reactome:R-HSA-8948747|refseq:NP_001273386.1|refseq:NP_003461.2|refseq:NP_001308787.1|ensembl:ENSP00000343535|ensembl:ENST00000381886|ensembl:ENSP00000371310|dip:DIP-29053N	go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0016579"(protein deubiquitination)	-	-	figure legend:S1d|comment:"UBA1 (P22314) and UBE2N:UBE2V1 (P61088, Q13404) are present in the reaction to get MEKK1 ubiquitinylated before adding the de-ubiquitinase."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:EwhjYjowkZIAt4UyPcZBUtf9uak10116	rogid:V+PXXBRM2zwlGQaeFiyjaQ9yf+A9606	intact-crc:7E4BB717C0B8A746|rigid:2yciLFnraWPRTxt59pH+2samnfY	false	ubiquitinylated lysine:?-?|sufficient binding region:433-481(IPR013083)	sufficient binding region:213-548(IPR028889)|his tag:n-n	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q62925	uniprotkb:P61088	intact:EBI-636664	intact:EBI-1052908|uniprotkb:Q16781|uniprotkb:Q53Y81|ensembl:ENSP00000316176	psi-mi:m3k1_rat(display_long)|uniprotkb:MAPK/ERK kinase kinase 1(gene name synonym)|uniprotkb:Map3k1(gene name)|psi-mi:Map3k1(display_short)|uniprotkb:Mekk(gene name synonym)|uniprotkb:Mekk1(gene name synonym)	psi-mi:ube2n_human(display_long)|uniprotkb:Ubiquitin-protein ligase N(gene name synonym)|uniprotkb:Ubiquitin carrier protein N(gene name synonym)|uniprotkb:Ubc13(gene name synonym)|uniprotkb:Bendless-like ubiquitin-conjugating enzyme(gene name synonym)|uniprotkb:UBE2N(gene name)|psi-mi:UBE2N(display_short)|uniprotkb:BLU(gene name synonym)|uniprotkb:UbcH13(gene name synonym)|uniprotkb:E2 ubiquitin-conjugating enzyme N(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9691535|imex:IM-22822-8	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:620966|refseq:NP_446339.1|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR007527(Zinc finger, SWIM-type)|go:"GO:0000165"(MAPK cascade)|interpro:IPR016024(Armadillo-type fold)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0002011"(morphogenesis of an epithelial sheet)|go:"GO:0003382"(epithelial cell morphogenesis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004706"(JUN kinase kinase kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007254"(JNK cascade)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008432"(JUN kinase binding)|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0016020"(membrane)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0031434"(mitogen-activated protein kinase kinase binding)|go:"GO:0031941"(filamentous actin)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0042060"(wound healing)|go:"GO:0043010"(camera-type eye development)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046625"(sphingolipid binding)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050434"(positive regulation of viral transcription)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0061029"(eyelid development in camera-type eye)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|reactome:R-RNO-166058|reactome:R-RNO-2871796|reactome:R-RNO-975138|reactome:R-RNO-975871|interpro:IPR011989(Armadillo-like helical)|mint:Q62925	refseq:NP_003339.1|dip:DIP-29829N|ensembl:ENSG00000177889(gene)|ensembl:ENST00000318066(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000729"(DNA double-strand break processing)|go:"GO:0001650"(fibrillar center)|go:"GO:0003723"(RNA binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006282"(regulation of DNA repair)|go:"GO:0006301"(postreplication repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016574"(histone ubiquitination)|go:"GO:0031058"(positive regulation of histone modification)|go:"GO:0031372"(UBC13-MMS2 complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033182"(regulation of histone ubiquitination)|go:"GO:0035370"(UBC13-UEV1A complex)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0061631"(ubiquitin conjugating enzyme activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070534"(protein K63-linked ubiquitination)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|interpro:IPR023313|rcsb pdb:1J7D|rcsb pdb:2C2V|rcsb pdb:3HCT|rcsb pdb:3HCU|rcsb pdb:3VON|rcsb pdb:3W31|rcsb pdb:4DHI|rcsb pdb:4DHJ|rcsb pdb:4DHZ|rcsb pdb:4IP3|rcsb pdb:4NR3|rcsb pdb:4NRG|rcsb pdb:4NRI|rcsb pdb:4ONL|rcsb pdb:4ONM|rcsb pdb:4ONN|rcsb pdb:4ORH|rcsb pdb:4TKP|rcsb pdb:4WHV|rcsb pdb:5AIT|rcsb pdb:5AIU|rcsb pdb:5EYA|rcsb pdb:5H7S|rcsb pdb:5VNZ|rcsb pdb:5VO0|rcsb pdb:5YWR|rcsb pdb:6D6I|rcsb pdb:6JKY|rcsb pdb:6KFP|rcsb pdb:6KG6|rcsb pdb:6KL4|rcsb pdb:6LP2|rcsb pdb:6P5B|rcsb pdb:6S53|reactome:R-HSA-168927|reactome:R-HSA-202424|reactome:R-HSA-2871837|reactome:R-HSA-445989|reactome:R-HSA-450302|reactome:R-HSA-450321|reactome:R-HSA-5607764|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-5696395|reactome:R-HSA-69473|reactome:R-HSA-8866654|reactome:R-HSA-9020702|reactome:R-HSA-937039|reactome:R-HSA-937041|reactome:R-HSA-9646399|reactome:R-HSA-975110|reactome:R-HSA-975144|reactome:R-HSA-983168|rcsb pdb:6ULH|rcsb pdb:6UMP|rcsb pdb:6UMS|rcsb pdb:7BBD|rcsb pdb:7BBF|rcsb pdb:7BXG|reactome:R-HSA-1169408|reactome:R-HSA-168638	-	-	-	figure legend:S1E|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/27	2014/11/05	rogid:EwhjYjowkZIAt4UyPcZBUtf9uak10116	rogid:dqdszHlq5FLPHC6UWX6uvkC6Yz89606	intact-crc:327EF5E636E968B9|rigid:g9qczB9jl8MhxkyKpwSsBHhOVuM	false	mutation disrupting interaction:440-440,438-438|necessary binding region:1-565	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q12933	uniprotkb:Q62925	intact:EBI-355744|uniprotkb:Q96NT2|uniprotkb:A8K107|uniprotkb:B4DPJ7|uniprotkb:Q7Z337|intact:EBI-1046651|ensembl:ENSP00000247668	intact:EBI-636664	psi-mi:traf2_human(display_long)|uniprotkb:TRAF2(gene name)|psi-mi:TRAF2(display_short)|uniprotkb:TRAP3(gene name synonym)|uniprotkb:Tumor necrosis factor type 2 receptor-associated protein 3(gene name synonym)|uniprotkb:E3 ubiquitin-protein ligase TRAF2(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase TRAF2(gene name synonym)	psi-mi:m3k1_rat(display_long)|uniprotkb:MAPK/ERK kinase kinase 1(gene name synonym)|uniprotkb:Map3k1(gene name)|psi-mi:Map3k1(display_short)|uniprotkb:Mekk(gene name synonym)|uniprotkb:Mekk1(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9691544|imex:IM-22822-9	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_066961.2|refseq:XP_011517279.1|refseq:XP_011517280.1|refseq:XP_011517276.1|refseq:XP_011517277.1|refseq:XP_011517278.1|ensembl:ENSG00000127191(gene)|ensembl:ENST00000247668(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0002637"(regulation of immunoglobulin production)|go:"GO:0002726"(positive regulation of T cell cytokine production)|go:"GO:0002947"(tumor necrosis factor receptor superfamily complex)|go:"GO:0043254"(regulation of protein-containing complex assembly)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046625"(sphingolipid binding)|go:"GO:0048255"(mRNA stabilization)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0071732"(cellular response to nitric oxide)|go:"GO:0097057"(TRAF2-GSTP1 complex)|go:"GO:0097300"(programmed necrotic cell death)|go:"GO:0097400"(interleukin-17-mediated signaling pathway)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1903265"(positive regulation of tumor necrosis factor-mediated signaling pathway)|go:"GO:1903721"(positive regulation of I-kappaB phosphorylation)|go:"GO:1990604"(IRE1-TRAF2-ASK1 complex)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|interpro:IPR001293(Zinc finger, TRAF-type)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR002083(MATH)|interpro:IPR008974(TRAF-like)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005174"(CD40 receptor binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005938"(cell cortex)|go:"GO:0007165"(signal transduction)|go:"GO:0007250"(activation of NF-kappaB-inducing kinase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0012506"(vesicle membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0023019"(signal transduction involved in regulation of gene expression)|go:"GO:0030163"(protein catabolic process)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031435"(mitogen-activated protein kinase kinase kinase binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031996"(thioesterase binding)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034351"(negative regulation of glial cell apoptotic process)|go:"GO:0034622"|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035631"(CD40 receptor complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043120"(tumor necrosis factor binding)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|interpro:IPR012227(TNF receptor-associated factor TRAF)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR018957|interpro:IPR027133|interpro:IPR032070|interpro:IPR037305|interpro:IPR043211|mint:Q12933|rcsb pdb:1CA4|rcsb pdb:1CA9|rcsb pdb:1CZY|rcsb pdb:1CZZ|rcsb pdb:1D00|rcsb pdb:1D01|rcsb pdb:1D0A|rcsb pdb:1D0J|rcsb pdb:1F3V|rcsb pdb:1QSC|rcsb pdb:3KNV|rcsb pdb:3M06|rcsb pdb:3M0A|rcsb pdb:3M0D|reactome:R-HSA-140534|reactome:R-HSA-3371378|reactome:R-HSA-5213460|reactome:R-HSA-5218900|reactome:R-HSA-5357786|reactome:R-HSA-5357905|reactome:R-HSA-5357956|reactome:R-HSA-5668541|reactome:R-HSA-5675482|reactome:R-HSA-5676594|reactome:R-HSA-5689880|reactome:R-HSA-69416|reactome:R-HSA-75893|reactome:R-HSA-933541|reactome:R-HSA-933542|reactome:R-HSA-9693928|refseq:XP_016870584.1|dip:DIP-6223N	rgd:620966|refseq:NP_446339.1|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR007527(Zinc finger, SWIM-type)|go:"GO:0000165"(MAPK cascade)|interpro:IPR016024(Armadillo-type fold)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0002011"(morphogenesis of an epithelial sheet)|go:"GO:0003382"(epithelial cell morphogenesis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004706"(JUN kinase kinase kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007254"(JNK cascade)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008432"(JUN kinase binding)|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0016020"(membrane)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0031434"(mitogen-activated protein kinase kinase binding)|go:"GO:0031941"(filamentous actin)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0042060"(wound healing)|go:"GO:0043010"(camera-type eye development)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046625"(sphingolipid binding)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050434"(positive regulation of viral transcription)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0061029"(eyelid development in camera-type eye)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|reactome:R-RNO-166058|reactome:R-RNO-2871796|reactome:R-RNO-975138|reactome:R-RNO-975871|interpro:IPR011989(Armadillo-like helical)|mint:Q62925	-	-	-	figure legend:S1E|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/06/27	2014/11/05	rogid:JhaoM5kRLh3zwhXr+BsCCRNOYa09606	rogid:EwhjYjowkZIAt4UyPcZBUtf9uak10116	intact-crc:89CD1B41FDAAF041|rigid:9g+d3Z8feV4gAoIjZCL0fPIHcx4	false	-	sufficient binding region:1-719	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P53349	uniprotkb:Q8CF89	intact:EBI-447913|uniprotkb:Q60831|uniprotkb:Q9R0U3|uniprotkb:Q9R256	intact:EBI-1778503|uniprotkb:Q7TQJ5|uniprotkb:Q80V65|uniprotkb:Q8R0D1|ensembl:ENSMUSP00000023050	psi-mi:m3k1_mouse(display_long)|uniprotkb:MAPK/ERK kinase kinase 1(gene name synonym)|uniprotkb:Map3k1(gene name)|psi-mi:Map3k1(display_short)|uniprotkb:Mekk(gene name synonym)|uniprotkb:Mekk1(gene name synonym)	psi-mi:tab1_mouse(display_long)|uniprotkb:Tab1(gene name)|psi-mi:Tab1(display_short)|uniprotkb:Map3k7ip1(gene name synonym)|uniprotkb:TGF-beta-activated kinase 1-binding protein 1(gene name synonym)|uniprotkb:Mitogen-activated protein kinase kinase kinase 7-interacting protein 1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9692155|imex:IM-22822-10	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0002011"(morphogenesis of an epithelial sheet)|go:"GO:0003382"(epithelial cell morphogenesis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004706"(JUN kinase kinase kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007254"(JNK cascade)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008432"(JUN kinase binding)|dip:DIP-32487N|mint:P53349|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0016020"(membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030054"(cell junction)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031434"(mitogen-activated protein kinase kinase binding)|go:"GO:0031941"(filamentous actin)|go:"GO:0042060"(wound healing)|go:"GO:0043010"(camera-type eye development)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046625"(sphingolipid binding)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0061029"(eyelid development in camera-type eye)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR007527(Zinc finger, SWIM-type)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|reactome:R-MMU-166058|reactome:R-MMU-2871796|reactome:R-MMU-975138|reactome:R-MMU-975871|interpro:IPR000719(Protein kinase, core)	refseq:NP_079885.2|ensembl:ENSMUSG00000022414(gene)|ensembl:ENSMUST00000023050(transcript)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0003279"(cardiac septum development)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0016607"(nuclear speck)|go:"GO:0016791"(phosphatase activity)|go:"GO:0019209"(kinase activator activity)|go:"GO:0030324"(lung development)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035904"(aorta development)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0048273"(mitogen-activated protein kinase p38 binding)|go:"GO:0060976"(coronary vasculature development)|interpro:IPR001932(Protein phosphatase 2C-related)|interpro:IPR015655(Protein phosphatase 2C)|interpro:IPR036457|mint:Q8CF89|rcsb pdb:4LOO|rcsb pdb:4LOP|rcsb pdb:4LOQ|reactome:R-MMU-168638|reactome:R-MMU-2871837|reactome:R-MMU-445989|reactome:R-MMU-450302|reactome:R-MMU-450321|reactome:R-MMU-5357956|reactome:R-MMU-5607764|reactome:R-MMU-5689880|reactome:R-MMU-9020702|reactome:R-MMU-937042|reactome:R-MMU-937072|reactome:R-MMU-9645460|reactome:R-MMU-975163	-	-	-	figure legend:S4b|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2014/06/27	2014/11/05	rogid:DR/c3qeWhJ76oKsNMEVhcUPmpXE10090	rogid:3/x6GPVcXE+UvI+pNiuMBkw70tM10090	intact-crc:4FF3349BD26EBB2E|rigid:KqJzsBv9OIcHunUbb2RXrFYCPDI	false	myc tag:n-n	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9NYJ8	uniprotkb:Q15750	intact:EBI-358708|uniprotkb:O94838|uniprotkb:Q6I9W8|uniprotkb:Q76N06|uniprotkb:Q9UFP7|uniprotkb:E1P5A0|uniprotkb:B2RCC4|ensembl:ENSP00000356426|ensembl:ENSP00000445752|ensembl:ENSP00000490618	intact:EBI-358643|uniprotkb:Q2PP09|intact:EBI-3959873|uniprotkb:Q8IZW2|ensembl:ENSP00000216160	psi-mi:tab2_human(display_long)|uniprotkb:TAB2(gene name)|psi-mi:TAB2(display_short)|uniprotkb:KIAA0733(gene name synonym)|uniprotkb:MAP3K7IP2(gene name synonym)|uniprotkb:TAK1-binding protein 2(gene name synonym)|uniprotkb:Mitogen-activated protein kinase kinase kinase 7-interacting protein 2(gene name synonym)|uniprotkb:TGF-beta-activated kinase 1-binding protein 2(gene name synonym)	psi-mi:tab1_human(display_long)|uniprotkb:TAB1(gene name)|psi-mi:TAB1(display_short)|uniprotkb:MAP3K7IP1(gene name synonym)|uniprotkb:TGF-beta-activated kinase 1-binding protein 1(gene name synonym)|uniprotkb:Mitogen-activated protein kinase kinase kinase 7-interacting protein 1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9875933|imex:IM-22822-12	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_055908.1|refseq:NP_001278963.1|refseq:NP_001278964.1|refseq:XP_011533935.1|ensembl:ENST00000637181(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|ensembl:ENST00000538427(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0007507"(heart development)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010008"(endosome membrane)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0070530"(K63-linked polyubiquitin modification-dependent protein binding)|interpro:IPR001876(Zinc finger, RanBP2-type)|interpro:IPR003892(Ubiquitin system component Cue)|interpro:IPR036443|interpro:IPR041911|mint:Q9NYJ8|rcsb pdb:2DAE|rcsb pdb:2WWZ|rcsb pdb:2WX0|rcsb pdb:2WX1|reactome:R-HSA-1251985|reactome:R-HSA-168638|reactome:R-HSA-202424|reactome:R-HSA-2871837|reactome:R-HSA-445989|reactome:R-HSA-450302|reactome:R-HSA-450321|reactome:R-HSA-5357956|reactome:R-HSA-5607764|reactome:R-HSA-9014325|reactome:R-HSA-9020702|reactome:R-HSA-937042|reactome:R-HSA-937072|reactome:R-HSA-9645460|reactome:R-HSA-975163|ensembl:ENST00000367456(transcript)|ensembl:ENSG00000055208(gene)|refseq:XP_016866080.1|refseq:XP_016866081.1|dip:DIP-27525N	refseq:NP_006107.1|refseq:NP_705717.1|ensembl:ENSP00000216160|ensembl:ENST00000331454|ensembl:ENSP00000333049|go:"GO:0003279"(cardiac septum development)|rcsb pdb:7NTI|go:"GO:0003007"(heart morphogenesis)|ensembl:ENSG00000100324(gene)|ensembl:ENST00000216160(transcript)|go:"GO:0000185"(obsolete activation of MAPKKK activity)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0008047"(enzyme activator activity)|go:"GO:0010008"(endosome membrane)|go:"GO:0016607"(nuclear speck)|go:"GO:0016791"(phosphatase activity)|go:"GO:0019209"(kinase activator activity)|go:"GO:0030324"(lung development)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035904"(aorta development)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0048273"(mitogen-activated protein kinase p38 binding)|go:"GO:0060976"(coronary vasculature development)|interpro:IPR001932(Protein phosphatase 2C-related)|interpro:IPR015655(Protein phosphatase 2C)|interpro:IPR036457|mint:Q15750|rcsb pdb:2J4O|rcsb pdb:2POM|rcsb pdb:2POP|rcsb pdb:2YDS|rcsb pdb:2YIY|rcsb pdb:4AY5|rcsb pdb:4AY6|rcsb pdb:4GS6|rcsb pdb:4KA3|rcsb pdb:4L3P|rcsb pdb:4L52|rcsb pdb:4L53|rcsb pdb:4O91|rcsb pdb:5DIY|rcsb pdb:5E7R|rcsb pdb:5GJD|rcsb pdb:5GJF|rcsb pdb:5GJG|rcsb pdb:5J7S|rcsb pdb:5J8I|rcsb pdb:5J9L|rcsb pdb:5JGA|rcsb pdb:5JGB|rcsb pdb:5JGD|rcsb pdb:5JH6|rcsb pdb:5JK3|rcsb pdb:5NZZ|rcsb pdb:5O90|rcsb pdb:5V5N|rcsb pdb:5VVU|rcsb pdb:7NTH|reactome:R-HSA-168638|reactome:R-HSA-2871837|reactome:R-HSA-445989|reactome:R-HSA-450302|reactome:R-HSA-450321|reactome:R-HSA-5357956|reactome:R-HSA-5607764|reactome:R-HSA-5689880|reactome:R-HSA-9014325|reactome:R-HSA-9020702|reactome:R-HSA-937042|reactome:R-HSA-937072|reactome:R-HSA-9645460|reactome:R-HSA-975163|dip:DIP-27524N	-	-	-	figure legend:5a|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2014/06/27	2014/10/30	rogid:hMWL5GobXJSsm8ToWVBF/ZwPX3M9606	rogid:28+bzs6bpXJTun4XukxC/7oAYSs9606	intact-crc:2731971644C9EB0F|rigid:2vF10XWBNfGiYtkd3c+HnH9ooUI	false	t7 tag:n-n|necessary binding region:663..663-693..693(IPR001876)	flag tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q13404	uniprotkb:P22314	intact:EBI-1050671|uniprotkb:Q13403|uniprotkb:Q13532|uniprotkb:Q96H34|uniprotkb:Q9GZT0|uniprotkb:Q9GZW1|uniprotkb:Q9H4J3|uniprotkb:Q9H4J4|uniprotkb:Q9UKL1|uniprotkb:Q9UM48|uniprotkb:Q9UM49|uniprotkb:Q9UM50|uniprotkb:Q5TGE3|uniprotkb:E1P629|uniprotkb:Q5TGE0|ensembl:ENSP00000360739	intact:EBI-709688|uniprotkb:Q96E13|uniprotkb:Q5JRR8|ensembl:ENSP00000338413|ensembl:ENSP00000366568	psi-mi:ub2v1_human(display_long)|uniprotkb:CROC-1(gene name synonym)|uniprotkb:TRAF6-regulated IKK activator 1 beta Uev1A(gene name synonym)|uniprotkb:P/OKcl.19(orf name)|uniprotkb:UBE2V1(gene name)|psi-mi:UBE2V1(display_short)|uniprotkb:CROC1(gene name synonym)|uniprotkb:UBE2V(gene name synonym)|uniprotkb:UEV1(gene name synonym)	psi-mi:uba1_human(display_long)|uniprotkb:Ubiquitin-activating enzyme E1(gene name synonym)|uniprotkb:Protein A1S9(gene name synonym)|uniprotkb:UBA1(gene name)|psi-mi:UBA1(display_short)|uniprotkb:A1S9T(gene name synonym)|uniprotkb:UBE1(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9970178|imex:IM-22822-13	author-confidence:Z-score = 17.60	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001027459.1|refseq:NP_068823.2|refseq:NP_071887.1|refseq:NP_954595.1|refseq:NP_954673.1|refseq:NP_001244322.1|refseq:NP_001244323.1|refseq:NP_001244325.1|ensembl:ENSG00000244687(gene)|ensembl:ENST00000371674(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006282"(regulation of DNA repair)|go:"GO:0006301"(postreplication repair)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0030154"(cell differentiation)|go:"GO:0031371"(ubiquitin conjugating enzyme complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035370"(UBC13-UEV1A complex)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070534"(protein K63-linked ubiquitination)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|rcsb pdb:2A4D|rcsb pdb:2C2V|rcsb pdb:2HLW|rcsb pdb:6D6I|reactome:R-HSA-168638|reactome:R-HSA-168927|reactome:R-HSA-202424|reactome:R-HSA-2871837|reactome:R-HSA-445989|reactome:R-HSA-450302|reactome:R-HSA-450321|reactome:R-HSA-5607764|reactome:R-HSA-9020702|reactome:R-HSA-937039|reactome:R-HSA-937041|reactome:R-HSA-9646399|reactome:R-HSA-975110|reactome:R-HSA-975144|reactome:R-HSA-983168|dip:DIP-41911N	refseq:NP_003325.2|refseq:NP_695012.1|refseq:XP_016885269.1|refseq:XP_016885270.1|dip:DIP-33686N|ensembl:ENSG00000130985(gene)|ensembl:ENST00000335972(transcript)|ensembl:ENST00000377351(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0004839"(ubiquitin activating enzyme activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0032446"(protein modification by small protein conjugation)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000011(Ubiquitin-activating enzyme, E1)|interpro:IPR000594(UBA/THIF-type NAD/FAD binding fold)|interpro:IPR018074|interpro:IPR018075|interpro:IPR018965|interpro:IPR019572|interpro:IPR032418|interpro:IPR032420|interpro:IPR033127|interpro:IPR035985|interpro:IPR038252|interpro:IPR042063|interpro:IPR042302|interpro:IPR042449|mint:P22314|rcsb pdb:4P22|rcsb pdb:6DC6|reactome:R-HSA-8866652|reactome:R-HSA-983168	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S2|caution:"UBE2N has been marked as the enzyme in this assay, although it is the UBE2N-UBE2V1 complex that has ubiquitinase (E3) activity. Neither UBE2N nor UBE2V1 have E2 or E3 activity on their own."|resulting-ptm:O00762 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:x95N7Dj2KIqu5gySX59xLmfthUg9606	rogid:q+vEeA0XLST0Zz173bmEt0dNbDE9606	intact-crc:B5E9D4ADA39BC2C2|rigid:ZIyEyT5ZHPwrQmIYAYyj5Up/UQo	false	his tag:?-?	his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q13404	uniprotkb:O00762	intact:EBI-1050671|uniprotkb:Q13403|uniprotkb:Q13532|uniprotkb:Q96H34|uniprotkb:Q9GZT0|uniprotkb:Q9GZW1|uniprotkb:Q9H4J3|uniprotkb:Q9H4J4|uniprotkb:Q9UKL1|uniprotkb:Q9UM48|uniprotkb:Q9UM49|uniprotkb:Q9UM50|uniprotkb:Q5TGE3|uniprotkb:E1P629|uniprotkb:Q5TGE0|ensembl:ENSP00000360739	intact:EBI-719691|uniprotkb:A6NP33|uniprotkb:E1P5N7|uniprotkb:G3XAB7|ensembl:ENSP00000348838	psi-mi:ub2v1_human(display_long)|uniprotkb:CROC-1(gene name synonym)|uniprotkb:TRAF6-regulated IKK activator 1 beta Uev1A(gene name synonym)|uniprotkb:P/OKcl.19(orf name)|uniprotkb:UBE2V1(gene name)|psi-mi:UBE2V1(display_short)|uniprotkb:CROC1(gene name synonym)|uniprotkb:UBE2V(gene name synonym)|uniprotkb:UEV1(gene name synonym)	psi-mi:ube2c_human(display_long)|uniprotkb:Ubiquitin-protein ligase C(gene name synonym)|uniprotkb:Ubiquitin carrier protein C(gene name synonym)|uniprotkb:UbcH10(gene name synonym)|uniprotkb:UBE2C(gene name)|psi-mi:UBE2C(display_short)|uniprotkb:UBCH10(gene name synonym)|uniprotkb:"(E3-independent) E2 ubiquitin-conjugating enzyme C"(gene name synonym)|uniprotkb:E2 ubiquitin-conjugating enzyme C(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9970178|imex:IM-22822-13	author-confidence:Z-score = 17.60	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001027459.1|refseq:NP_068823.2|refseq:NP_071887.1|refseq:NP_954595.1|refseq:NP_954673.1|refseq:NP_001244322.1|refseq:NP_001244323.1|refseq:NP_001244325.1|ensembl:ENSG00000244687(gene)|ensembl:ENST00000371674(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006282"(regulation of DNA repair)|go:"GO:0006301"(postreplication repair)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0030154"(cell differentiation)|go:"GO:0031371"(ubiquitin conjugating enzyme complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035370"(UBC13-UEV1A complex)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070534"(protein K63-linked ubiquitination)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|rcsb pdb:2A4D|rcsb pdb:2C2V|rcsb pdb:2HLW|rcsb pdb:6D6I|reactome:R-HSA-168638|reactome:R-HSA-168927|reactome:R-HSA-202424|reactome:R-HSA-2871837|reactome:R-HSA-445989|reactome:R-HSA-450302|reactome:R-HSA-450321|reactome:R-HSA-5607764|reactome:R-HSA-9020702|reactome:R-HSA-937039|reactome:R-HSA-937041|reactome:R-HSA-9646399|reactome:R-HSA-975110|reactome:R-HSA-975144|reactome:R-HSA-983168|dip:DIP-41911N	refseq:NP_008950.1|refseq:NP_861515.1|refseq:NP_861516.1|refseq:NP_861517.1|ensembl:ENSG00000175063(gene)|ensembl:ENST00000356455(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005680"(anaphase-promoting complex)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0010458"(exit from mitosis)|go:"GO:0010994"(free ubiquitin chain polymerization)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0030071"(regulation of mitotic metaphase/anaphase transition)|go:"GO:0031145"(anaphase-promoting complex-dependent catabolic process)|go:"GO:0031536"(positive regulation of exit from mitosis)|go:"GO:0044389"(ubiquitin-like protein ligase binding)|go:"GO:0051301"(cell division)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0061631"(ubiquitin conjugating enzyme activity)|go:"GO:0070936"(protein K48-linked ubiquitination)|go:"GO:0070979"(protein K11-linked ubiquitination)|go:"GO:1904668"(positive regulation of ubiquitin protein ligase activity)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|interpro:IPR023313|rcsb pdb:1I7K|rcsb pdb:4YII|rcsb pdb:5A31|rcsb pdb:5KHR|rcsb pdb:5L9U|reactome:R-HSA-141430|reactome:R-HSA-174048|reactome:R-HSA-174084|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-176407|reactome:R-HSA-176408|reactome:R-HSA-176409|reactome:R-HSA-176412|reactome:R-HSA-179409|reactome:R-HSA-2467813|reactome:R-HSA-2559582|reactome:R-HSA-69017|reactome:R-HSA-8853884|reactome:R-HSA-8866652|reactome:R-HSA-9687136|reactome:R-HSA-983168|refseq:NP_001268670.1|refseq:NP_001268671.1|dip:DIP-52725N	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S2|caution:"UBE2N has been marked as the enzyme in this assay, although it is the UBE2N-UBE2V1 complex that has ubiquitinase (E3) activity. Neither UBE2N nor UBE2V1 have E2 or E3 activity on their own."|resulting-ptm:O00762 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:x95N7Dj2KIqu5gySX59xLmfthUg9606	rogid:sJ/R8NL1aVdljasuqKJbVg8gyTM9606	intact-crc:B5E9D4ADA39BC2C2|rigid:ZIyEyT5ZHPwrQmIYAYyj5Up/UQo	false	his tag:?-?	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q13404	uniprotkb:P61088	intact:EBI-1050671|uniprotkb:Q13403|uniprotkb:Q13532|uniprotkb:Q96H34|uniprotkb:Q9GZT0|uniprotkb:Q9GZW1|uniprotkb:Q9H4J3|uniprotkb:Q9H4J4|uniprotkb:Q9UKL1|uniprotkb:Q9UM48|uniprotkb:Q9UM49|uniprotkb:Q9UM50|uniprotkb:Q5TGE3|uniprotkb:E1P629|uniprotkb:Q5TGE0|ensembl:ENSP00000360739	intact:EBI-1052908|uniprotkb:Q16781|uniprotkb:Q53Y81|ensembl:ENSP00000316176	psi-mi:ub2v1_human(display_long)|uniprotkb:CROC-1(gene name synonym)|uniprotkb:TRAF6-regulated IKK activator 1 beta Uev1A(gene name synonym)|uniprotkb:P/OKcl.19(orf name)|uniprotkb:UBE2V1(gene name)|psi-mi:UBE2V1(display_short)|uniprotkb:CROC1(gene name synonym)|uniprotkb:UBE2V(gene name synonym)|uniprotkb:UEV1(gene name synonym)	psi-mi:ube2n_human(display_long)|uniprotkb:Ubiquitin-protein ligase N(gene name synonym)|uniprotkb:Ubiquitin carrier protein N(gene name synonym)|uniprotkb:Ubc13(gene name synonym)|uniprotkb:Bendless-like ubiquitin-conjugating enzyme(gene name synonym)|uniprotkb:UBE2N(gene name)|psi-mi:UBE2N(display_short)|uniprotkb:BLU(gene name synonym)|uniprotkb:UbcH13(gene name synonym)|uniprotkb:E2 ubiquitin-conjugating enzyme N(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9970178|imex:IM-22822-13	author-confidence:Z-score = 17.60	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001027459.1|refseq:NP_068823.2|refseq:NP_071887.1|refseq:NP_954595.1|refseq:NP_954673.1|refseq:NP_001244322.1|refseq:NP_001244323.1|refseq:NP_001244325.1|ensembl:ENSG00000244687(gene)|ensembl:ENST00000371674(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006282"(regulation of DNA repair)|go:"GO:0006301"(postreplication repair)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0030154"(cell differentiation)|go:"GO:0031371"(ubiquitin conjugating enzyme complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035370"(UBC13-UEV1A complex)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070534"(protein K63-linked ubiquitination)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|rcsb pdb:2A4D|rcsb pdb:2C2V|rcsb pdb:2HLW|rcsb pdb:6D6I|reactome:R-HSA-168638|reactome:R-HSA-168927|reactome:R-HSA-202424|reactome:R-HSA-2871837|reactome:R-HSA-445989|reactome:R-HSA-450302|reactome:R-HSA-450321|reactome:R-HSA-5607764|reactome:R-HSA-9020702|reactome:R-HSA-937039|reactome:R-HSA-937041|reactome:R-HSA-9646399|reactome:R-HSA-975110|reactome:R-HSA-975144|reactome:R-HSA-983168|dip:DIP-41911N	refseq:NP_003339.1|dip:DIP-29829N|ensembl:ENSG00000177889(gene)|ensembl:ENST00000318066(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000729"(DNA double-strand break processing)|go:"GO:0001650"(fibrillar center)|go:"GO:0003723"(RNA binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006282"(regulation of DNA repair)|go:"GO:0006301"(postreplication repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016574"(histone ubiquitination)|go:"GO:0031058"(positive regulation of histone modification)|go:"GO:0031372"(UBC13-MMS2 complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033182"(regulation of histone ubiquitination)|go:"GO:0035370"(UBC13-UEV1A complex)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0061631"(ubiquitin conjugating enzyme activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070534"(protein K63-linked ubiquitination)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|interpro:IPR023313|rcsb pdb:1J7D|rcsb pdb:2C2V|rcsb pdb:3HCT|rcsb pdb:3HCU|rcsb pdb:3VON|rcsb pdb:3W31|rcsb pdb:4DHI|rcsb pdb:4DHJ|rcsb pdb:4DHZ|rcsb pdb:4IP3|rcsb pdb:4NR3|rcsb pdb:4NRG|rcsb pdb:4NRI|rcsb pdb:4ONL|rcsb pdb:4ONM|rcsb pdb:4ONN|rcsb pdb:4ORH|rcsb pdb:4TKP|rcsb pdb:4WHV|rcsb pdb:5AIT|rcsb pdb:5AIU|rcsb pdb:5EYA|rcsb pdb:5H7S|rcsb pdb:5VNZ|rcsb pdb:5VO0|rcsb pdb:5YWR|rcsb pdb:6D6I|rcsb pdb:6JKY|rcsb pdb:6KFP|rcsb pdb:6KG6|rcsb pdb:6KL4|rcsb pdb:6LP2|rcsb pdb:6P5B|rcsb pdb:6S53|reactome:R-HSA-168927|reactome:R-HSA-202424|reactome:R-HSA-2871837|reactome:R-HSA-445989|reactome:R-HSA-450302|reactome:R-HSA-450321|reactome:R-HSA-5607764|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-5696395|reactome:R-HSA-69473|reactome:R-HSA-8866654|reactome:R-HSA-9020702|reactome:R-HSA-937039|reactome:R-HSA-937041|reactome:R-HSA-9646399|reactome:R-HSA-975110|reactome:R-HSA-975144|reactome:R-HSA-983168|rcsb pdb:6ULH|rcsb pdb:6UMP|rcsb pdb:6UMS|rcsb pdb:7BBD|rcsb pdb:7BBF|rcsb pdb:7BXG|reactome:R-HSA-1169408|reactome:R-HSA-168638	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S2|caution:"UBE2N has been marked as the enzyme in this assay, although it is the UBE2N-UBE2V1 complex that has ubiquitinase (E3) activity. Neither UBE2N nor UBE2V1 have E2 or E3 activity on their own."|resulting-ptm:O00762 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:x95N7Dj2KIqu5gySX59xLmfthUg9606	rogid:dqdszHlq5FLPHC6UWX6uvkC6Yz89606	intact-crc:B5E9D4ADA39BC2C2|rigid:ZIyEyT5ZHPwrQmIYAYyj5Up/UQo	false	his tag:?-?	his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O14730	uniprotkb:Q13404	intact:EBI-1047061|uniprotkb:Q8IXN9|ensembl:ENSP00000341874	intact:EBI-1050671|uniprotkb:Q13403|uniprotkb:Q13532|uniprotkb:Q96H34|uniprotkb:Q9GZT0|uniprotkb:Q9GZW1|uniprotkb:Q9H4J3|uniprotkb:Q9H4J4|uniprotkb:Q9UKL1|uniprotkb:Q9UM48|uniprotkb:Q9UM49|uniprotkb:Q9UM50|uniprotkb:Q5TGE3|uniprotkb:E1P629|uniprotkb:Q5TGE0|ensembl:ENSP00000360739	psi-mi:riok3_human(display_long)|uniprotkb:sudD homolog(gene name synonym)|uniprotkb:RIOK3(gene name)|psi-mi:RIOK3(display_short)|uniprotkb:SUDD(gene name synonym)|uniprotkb:RIO kinase 3(gene name synonym)	psi-mi:ub2v1_human(display_long)|uniprotkb:CROC-1(gene name synonym)|uniprotkb:TRAF6-regulated IKK activator 1 beta Uev1A(gene name synonym)|uniprotkb:P/OKcl.19(orf name)|uniprotkb:UBE2V1(gene name)|psi-mi:UBE2V1(display_short)|uniprotkb:CROC1(gene name synonym)|uniprotkb:UBE2V(gene name synonym)|uniprotkb:UEV1(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9970199|imex:IM-22822-14	author-confidence:Z-score = 3.27	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_003822.2|ensembl:ENSG00000101782(gene)|ensembl:ENST00000339486(transcript)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0007059"(chromosome segregation)|go:"GO:0030490"(maturation of SSU-rRNA)|go:"GO:0030688"(preribosome, small subunit precursor)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0039534"(negative regulation of MDA-5 signaling pathway)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045087"(innate immune response)|go:"GO:0045089"(positive regulation of innate immune response)|go:"GO:0046872"(metal ion binding)|go:"GO:0051607"(defense response to virus)|go:"GO:0071359"(cellular response to dsRNA)|go:"GO:0089720"(caspase binding)|go:"GO:0098586"(cellular response to virus)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1990786"(cellular response to dsDNA)|interpro:IPR000687(RIO kinase)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017406(Serine/threonine-protein kinase Rio3)|interpro:IPR018935|reactome:R-HSA-6791226	refseq:NP_001027459.1|refseq:NP_068823.2|refseq:NP_071887.1|refseq:NP_954595.1|refseq:NP_954673.1|refseq:NP_001244322.1|refseq:NP_001244323.1|refseq:NP_001244325.1|ensembl:ENSG00000244687(gene)|ensembl:ENST00000371674(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006282"(regulation of DNA repair)|go:"GO:0006301"(postreplication repair)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0030154"(cell differentiation)|go:"GO:0031371"(ubiquitin conjugating enzyme complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035370"(UBC13-UEV1A complex)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070534"(protein K63-linked ubiquitination)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|rcsb pdb:2A4D|rcsb pdb:2C2V|rcsb pdb:2HLW|rcsb pdb:6D6I|reactome:R-HSA-168638|reactome:R-HSA-168927|reactome:R-HSA-202424|reactome:R-HSA-2871837|reactome:R-HSA-445989|reactome:R-HSA-450302|reactome:R-HSA-450321|reactome:R-HSA-5607764|reactome:R-HSA-9020702|reactome:R-HSA-937039|reactome:R-HSA-937041|reactome:R-HSA-9646399|reactome:R-HSA-975110|reactome:R-HSA-975144|reactome:R-HSA-983168|dip:DIP-41911N	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S2|caution:"UBE2N has been marked as the enzyme in this assay, although it is the UBE2N-UBE2V1 complex that has ubiquitinase (E3) activity. Neither UBE2N nor UBE2V1 have E2 or E3 activity on their own."|resulting-ptm:O14730 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:pC/TdpTG0HK/d1F4KIIpU3bzTcg9606	rogid:x95N7Dj2KIqu5gySX59xLmfthUg9606	intact-crc:E2A6A54CB6DD15E5|rigid:gZQEAuiJPc3Q5/xu/Il8bO7o6ik	false	-	his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O14730	uniprotkb:P22314	intact:EBI-1047061|uniprotkb:Q8IXN9|ensembl:ENSP00000341874	intact:EBI-709688|uniprotkb:Q96E13|uniprotkb:Q5JRR8|ensembl:ENSP00000338413|ensembl:ENSP00000366568	psi-mi:riok3_human(display_long)|uniprotkb:sudD homolog(gene name synonym)|uniprotkb:RIOK3(gene name)|psi-mi:RIOK3(display_short)|uniprotkb:SUDD(gene name synonym)|uniprotkb:RIO kinase 3(gene name synonym)	psi-mi:uba1_human(display_long)|uniprotkb:Ubiquitin-activating enzyme E1(gene name synonym)|uniprotkb:Protein A1S9(gene name synonym)|uniprotkb:UBA1(gene name)|psi-mi:UBA1(display_short)|uniprotkb:A1S9T(gene name synonym)|uniprotkb:UBE1(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9970199|imex:IM-22822-14	author-confidence:Z-score = 3.27	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_003822.2|ensembl:ENSG00000101782(gene)|ensembl:ENST00000339486(transcript)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0007059"(chromosome segregation)|go:"GO:0030490"(maturation of SSU-rRNA)|go:"GO:0030688"(preribosome, small subunit precursor)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0039534"(negative regulation of MDA-5 signaling pathway)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045087"(innate immune response)|go:"GO:0045089"(positive regulation of innate immune response)|go:"GO:0046872"(metal ion binding)|go:"GO:0051607"(defense response to virus)|go:"GO:0071359"(cellular response to dsRNA)|go:"GO:0089720"(caspase binding)|go:"GO:0098586"(cellular response to virus)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1990786"(cellular response to dsDNA)|interpro:IPR000687(RIO kinase)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017406(Serine/threonine-protein kinase Rio3)|interpro:IPR018935|reactome:R-HSA-6791226	refseq:NP_003325.2|refseq:NP_695012.1|refseq:XP_016885269.1|refseq:XP_016885270.1|dip:DIP-33686N|ensembl:ENSG00000130985(gene)|ensembl:ENST00000335972(transcript)|ensembl:ENST00000377351(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0004839"(ubiquitin activating enzyme activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0032446"(protein modification by small protein conjugation)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000011(Ubiquitin-activating enzyme, E1)|interpro:IPR000594(UBA/THIF-type NAD/FAD binding fold)|interpro:IPR018074|interpro:IPR018075|interpro:IPR018965|interpro:IPR019572|interpro:IPR032418|interpro:IPR032420|interpro:IPR033127|interpro:IPR035985|interpro:IPR038252|interpro:IPR042063|interpro:IPR042302|interpro:IPR042449|mint:P22314|rcsb pdb:4P22|rcsb pdb:6DC6|reactome:R-HSA-8866652|reactome:R-HSA-983168	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S2|caution:"UBE2N has been marked as the enzyme in this assay, although it is the UBE2N-UBE2V1 complex that has ubiquitinase (E3) activity. Neither UBE2N nor UBE2V1 have E2 or E3 activity on their own."|resulting-ptm:O14730 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:pC/TdpTG0HK/d1F4KIIpU3bzTcg9606	rogid:q+vEeA0XLST0Zz173bmEt0dNbDE9606	intact-crc:E2A6A54CB6DD15E5|rigid:gZQEAuiJPc3Q5/xu/Il8bO7o6ik	false	-	his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O14730	uniprotkb:P61088	intact:EBI-1047061|uniprotkb:Q8IXN9|ensembl:ENSP00000341874	intact:EBI-1052908|uniprotkb:Q16781|uniprotkb:Q53Y81|ensembl:ENSP00000316176	psi-mi:riok3_human(display_long)|uniprotkb:sudD homolog(gene name synonym)|uniprotkb:RIOK3(gene name)|psi-mi:RIOK3(display_short)|uniprotkb:SUDD(gene name synonym)|uniprotkb:RIO kinase 3(gene name synonym)	psi-mi:ube2n_human(display_long)|uniprotkb:Ubiquitin-protein ligase N(gene name synonym)|uniprotkb:Ubiquitin carrier protein N(gene name synonym)|uniprotkb:Ubc13(gene name synonym)|uniprotkb:Bendless-like ubiquitin-conjugating enzyme(gene name synonym)|uniprotkb:UBE2N(gene name)|psi-mi:UBE2N(display_short)|uniprotkb:BLU(gene name synonym)|uniprotkb:UbcH13(gene name synonym)|uniprotkb:E2 ubiquitin-conjugating enzyme N(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9970199|imex:IM-22822-14	author-confidence:Z-score = 3.27	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_003822.2|ensembl:ENSG00000101782(gene)|ensembl:ENST00000339486(transcript)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0007059"(chromosome segregation)|go:"GO:0030490"(maturation of SSU-rRNA)|go:"GO:0030688"(preribosome, small subunit precursor)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0039534"(negative regulation of MDA-5 signaling pathway)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045087"(innate immune response)|go:"GO:0045089"(positive regulation of innate immune response)|go:"GO:0046872"(metal ion binding)|go:"GO:0051607"(defense response to virus)|go:"GO:0071359"(cellular response to dsRNA)|go:"GO:0089720"(caspase binding)|go:"GO:0098586"(cellular response to virus)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1990786"(cellular response to dsDNA)|interpro:IPR000687(RIO kinase)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017406(Serine/threonine-protein kinase Rio3)|interpro:IPR018935|reactome:R-HSA-6791226	refseq:NP_003339.1|dip:DIP-29829N|ensembl:ENSG00000177889(gene)|ensembl:ENST00000318066(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000729"(DNA double-strand break processing)|go:"GO:0001650"(fibrillar center)|go:"GO:0003723"(RNA binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006282"(regulation of DNA repair)|go:"GO:0006301"(postreplication repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016574"(histone ubiquitination)|go:"GO:0031058"(positive regulation of histone modification)|go:"GO:0031372"(UBC13-MMS2 complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033182"(regulation of histone ubiquitination)|go:"GO:0035370"(UBC13-UEV1A complex)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0061631"(ubiquitin conjugating enzyme activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070534"(protein K63-linked ubiquitination)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|interpro:IPR023313|rcsb pdb:1J7D|rcsb pdb:2C2V|rcsb pdb:3HCT|rcsb pdb:3HCU|rcsb pdb:3VON|rcsb pdb:3W31|rcsb pdb:4DHI|rcsb pdb:4DHJ|rcsb pdb:4DHZ|rcsb pdb:4IP3|rcsb pdb:4NR3|rcsb pdb:4NRG|rcsb pdb:4NRI|rcsb pdb:4ONL|rcsb pdb:4ONM|rcsb pdb:4ONN|rcsb pdb:4ORH|rcsb pdb:4TKP|rcsb pdb:4WHV|rcsb pdb:5AIT|rcsb pdb:5AIU|rcsb pdb:5EYA|rcsb pdb:5H7S|rcsb pdb:5VNZ|rcsb pdb:5VO0|rcsb pdb:5YWR|rcsb pdb:6D6I|rcsb pdb:6JKY|rcsb pdb:6KFP|rcsb pdb:6KG6|rcsb pdb:6KL4|rcsb pdb:6LP2|rcsb pdb:6P5B|rcsb pdb:6S53|reactome:R-HSA-168927|reactome:R-HSA-202424|reactome:R-HSA-2871837|reactome:R-HSA-445989|reactome:R-HSA-450302|reactome:R-HSA-450321|reactome:R-HSA-5607764|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-5696395|reactome:R-HSA-69473|reactome:R-HSA-8866654|reactome:R-HSA-9020702|reactome:R-HSA-937039|reactome:R-HSA-937041|reactome:R-HSA-9646399|reactome:R-HSA-975110|reactome:R-HSA-975144|reactome:R-HSA-983168|rcsb pdb:6ULH|rcsb pdb:6UMP|rcsb pdb:6UMS|rcsb pdb:7BBD|rcsb pdb:7BBF|rcsb pdb:7BXG|reactome:R-HSA-1169408|reactome:R-HSA-168638	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S2|caution:"UBE2N has been marked as the enzyme in this assay, although it is the UBE2N-UBE2V1 complex that has ubiquitinase (E3) activity. Neither UBE2N nor UBE2V1 have E2 or E3 activity on their own."|resulting-ptm:O14730 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:pC/TdpTG0HK/d1F4KIIpU3bzTcg9606	rogid:dqdszHlq5FLPHC6UWX6uvkC6Yz89606	intact-crc:E2A6A54CB6DD15E5|rigid:gZQEAuiJPc3Q5/xu/Il8bO7o6ik	false	-	his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O43567	uniprotkb:Q13404	intact:EBI-2129183|uniprotkb:Q6IBJ9|uniprotkb:A6NC87|uniprotkb:B3KR12|uniprotkb:Q05D66|ensembl:ENSP00000341361|ensembl:ENSP00000376628	intact:EBI-1050671|uniprotkb:Q13403|uniprotkb:Q13532|uniprotkb:Q96H34|uniprotkb:Q9GZT0|uniprotkb:Q9GZW1|uniprotkb:Q9H4J3|uniprotkb:Q9H4J4|uniprotkb:Q9UKL1|uniprotkb:Q9UM48|uniprotkb:Q9UM49|uniprotkb:Q9UM50|uniprotkb:Q5TGE3|uniprotkb:E1P629|uniprotkb:Q5TGE0|ensembl:ENSP00000360739	psi-mi:rnf13_human(display_long)|uniprotkb:RNF13(gene name)|psi-mi:RNF13(display_short)|uniprotkb:RING finger protein 13(gene name synonym)|uniprotkb:RZF(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase RNF13(gene name synonym)	psi-mi:ub2v1_human(display_long)|uniprotkb:CROC-1(gene name synonym)|uniprotkb:TRAF6-regulated IKK activator 1 beta Uev1A(gene name synonym)|uniprotkb:P/OKcl.19(orf name)|uniprotkb:UBE2V1(gene name)|psi-mi:UBE2V1(display_short)|uniprotkb:CROC1(gene name synonym)|uniprotkb:UBE2V(gene name synonym)|uniprotkb:UEV1(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9970220|imex:IM-22822-15	author-confidence:Z-score = 18.61	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011510675.1|refseq:XP_011510676.1|refseq:XP_011510678.1|refseq:NP_009213.1|refseq:NP_899237.1|refseq:XP_005247149.1|refseq:XP_016861145.1|refseq:XP_016861146.1|refseq:XP_016861147.1|refseq:XP_016861148.1|refseq:XP_016861143.1|refseq:XP_016861144.1|ensembl:ENSG00000082996(gene)|ensembl:ENST00000344229(transcript)|ensembl:ENST00000392894(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005637"(nuclear inner membrane)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008432"(JUN kinase binding)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031902"(late endosome membrane)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0046872"(metal ion binding)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070304"(positive regulation of stress-activated protein kinase signaling cascade)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR003137(Protease-associated PA)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR044744|rcsb pdb:5ZBU|rcsb pdb:5ZC4	refseq:NP_001027459.1|refseq:NP_068823.2|refseq:NP_071887.1|refseq:NP_954595.1|refseq:NP_954673.1|refseq:NP_001244322.1|refseq:NP_001244323.1|refseq:NP_001244325.1|ensembl:ENSG00000244687(gene)|ensembl:ENST00000371674(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006282"(regulation of DNA repair)|go:"GO:0006301"(postreplication repair)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0030154"(cell differentiation)|go:"GO:0031371"(ubiquitin conjugating enzyme complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035370"(UBC13-UEV1A complex)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070534"(protein K63-linked ubiquitination)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|rcsb pdb:2A4D|rcsb pdb:2C2V|rcsb pdb:2HLW|rcsb pdb:6D6I|reactome:R-HSA-168638|reactome:R-HSA-168927|reactome:R-HSA-202424|reactome:R-HSA-2871837|reactome:R-HSA-445989|reactome:R-HSA-450302|reactome:R-HSA-450321|reactome:R-HSA-5607764|reactome:R-HSA-9020702|reactome:R-HSA-937039|reactome:R-HSA-937041|reactome:R-HSA-9646399|reactome:R-HSA-975110|reactome:R-HSA-975144|reactome:R-HSA-983168|dip:DIP-41911N	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S2|caution:"UBE2N has been marked as the enzyme in this assay, although it is the UBE2N-UBE2V1 complex that has ubiquitinase (E3) activity. Neither UBE2N nor UBE2V1 have E2 or E3 activity on their own."|resulting-ptm:O43567 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:1TRv4QAAbl5n5VZd2h7OrFpDXKE9606	rogid:x95N7Dj2KIqu5gySX59xLmfthUg9606	intact-crc:B205F8F93BDB1EFC|rigid:vzYiH21K1Ft74WrR0jBARQdinMc	false	-	his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O43567	uniprotkb:P22314	intact:EBI-2129183|uniprotkb:Q6IBJ9|uniprotkb:A6NC87|uniprotkb:B3KR12|uniprotkb:Q05D66|ensembl:ENSP00000341361|ensembl:ENSP00000376628	intact:EBI-709688|uniprotkb:Q96E13|uniprotkb:Q5JRR8|ensembl:ENSP00000338413|ensembl:ENSP00000366568	psi-mi:rnf13_human(display_long)|uniprotkb:RNF13(gene name)|psi-mi:RNF13(display_short)|uniprotkb:RING finger protein 13(gene name synonym)|uniprotkb:RZF(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase RNF13(gene name synonym)	psi-mi:uba1_human(display_long)|uniprotkb:Ubiquitin-activating enzyme E1(gene name synonym)|uniprotkb:Protein A1S9(gene name synonym)|uniprotkb:UBA1(gene name)|psi-mi:UBA1(display_short)|uniprotkb:A1S9T(gene name synonym)|uniprotkb:UBE1(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9970220|imex:IM-22822-15	author-confidence:Z-score = 18.61	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011510675.1|refseq:XP_011510676.1|refseq:XP_011510678.1|refseq:NP_009213.1|refseq:NP_899237.1|refseq:XP_005247149.1|refseq:XP_016861145.1|refseq:XP_016861146.1|refseq:XP_016861147.1|refseq:XP_016861148.1|refseq:XP_016861143.1|refseq:XP_016861144.1|ensembl:ENSG00000082996(gene)|ensembl:ENST00000344229(transcript)|ensembl:ENST00000392894(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005637"(nuclear inner membrane)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008432"(JUN kinase binding)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031902"(late endosome membrane)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0046872"(metal ion binding)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070304"(positive regulation of stress-activated protein kinase signaling cascade)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR003137(Protease-associated PA)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR044744|rcsb pdb:5ZBU|rcsb pdb:5ZC4	refseq:NP_003325.2|refseq:NP_695012.1|refseq:XP_016885269.1|refseq:XP_016885270.1|dip:DIP-33686N|ensembl:ENSG00000130985(gene)|ensembl:ENST00000335972(transcript)|ensembl:ENST00000377351(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0004839"(ubiquitin activating enzyme activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0032446"(protein modification by small protein conjugation)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000011(Ubiquitin-activating enzyme, E1)|interpro:IPR000594(UBA/THIF-type NAD/FAD binding fold)|interpro:IPR018074|interpro:IPR018075|interpro:IPR018965|interpro:IPR019572|interpro:IPR032418|interpro:IPR032420|interpro:IPR033127|interpro:IPR035985|interpro:IPR038252|interpro:IPR042063|interpro:IPR042302|interpro:IPR042449|mint:P22314|rcsb pdb:4P22|rcsb pdb:6DC6|reactome:R-HSA-8866652|reactome:R-HSA-983168	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S2|caution:"UBE2N has been marked as the enzyme in this assay, although it is the UBE2N-UBE2V1 complex that has ubiquitinase (E3) activity. Neither UBE2N nor UBE2V1 have E2 or E3 activity on their own."|resulting-ptm:O43567 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:1TRv4QAAbl5n5VZd2h7OrFpDXKE9606	rogid:q+vEeA0XLST0Zz173bmEt0dNbDE9606	intact-crc:B205F8F93BDB1EFC|rigid:vzYiH21K1Ft74WrR0jBARQdinMc	false	-	his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O43567	uniprotkb:P61088	intact:EBI-2129183|uniprotkb:Q6IBJ9|uniprotkb:A6NC87|uniprotkb:B3KR12|uniprotkb:Q05D66|ensembl:ENSP00000341361|ensembl:ENSP00000376628	intact:EBI-1052908|uniprotkb:Q16781|uniprotkb:Q53Y81|ensembl:ENSP00000316176	psi-mi:rnf13_human(display_long)|uniprotkb:RNF13(gene name)|psi-mi:RNF13(display_short)|uniprotkb:RING finger protein 13(gene name synonym)|uniprotkb:RZF(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase RNF13(gene name synonym)	psi-mi:ube2n_human(display_long)|uniprotkb:Ubiquitin-protein ligase N(gene name synonym)|uniprotkb:Ubiquitin carrier protein N(gene name synonym)|uniprotkb:Ubc13(gene name synonym)|uniprotkb:Bendless-like ubiquitin-conjugating enzyme(gene name synonym)|uniprotkb:UBE2N(gene name)|psi-mi:UBE2N(display_short)|uniprotkb:BLU(gene name synonym)|uniprotkb:UbcH13(gene name synonym)|uniprotkb:E2 ubiquitin-conjugating enzyme N(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9970220|imex:IM-22822-15	author-confidence:Z-score = 18.61	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011510675.1|refseq:XP_011510676.1|refseq:XP_011510678.1|refseq:NP_009213.1|refseq:NP_899237.1|refseq:XP_005247149.1|refseq:XP_016861145.1|refseq:XP_016861146.1|refseq:XP_016861147.1|refseq:XP_016861148.1|refseq:XP_016861143.1|refseq:XP_016861144.1|ensembl:ENSG00000082996(gene)|ensembl:ENST00000344229(transcript)|ensembl:ENST00000392894(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005637"(nuclear inner membrane)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008432"(JUN kinase binding)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031902"(late endosome membrane)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0046872"(metal ion binding)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070304"(positive regulation of stress-activated protein kinase signaling cascade)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR003137(Protease-associated PA)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR044744|rcsb pdb:5ZBU|rcsb pdb:5ZC4	refseq:NP_003339.1|dip:DIP-29829N|ensembl:ENSG00000177889(gene)|ensembl:ENST00000318066(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000729"(DNA double-strand break processing)|go:"GO:0001650"(fibrillar center)|go:"GO:0003723"(RNA binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006282"(regulation of DNA repair)|go:"GO:0006301"(postreplication repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016574"(histone ubiquitination)|go:"GO:0031058"(positive regulation of histone modification)|go:"GO:0031372"(UBC13-MMS2 complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033182"(regulation of histone ubiquitination)|go:"GO:0035370"(UBC13-UEV1A complex)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0061631"(ubiquitin conjugating enzyme activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070534"(protein K63-linked ubiquitination)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|interpro:IPR023313|rcsb pdb:1J7D|rcsb pdb:2C2V|rcsb pdb:3HCT|rcsb pdb:3HCU|rcsb pdb:3VON|rcsb pdb:3W31|rcsb pdb:4DHI|rcsb pdb:4DHJ|rcsb pdb:4DHZ|rcsb pdb:4IP3|rcsb pdb:4NR3|rcsb pdb:4NRG|rcsb pdb:4NRI|rcsb pdb:4ONL|rcsb pdb:4ONM|rcsb pdb:4ONN|rcsb pdb:4ORH|rcsb pdb:4TKP|rcsb pdb:4WHV|rcsb pdb:5AIT|rcsb pdb:5AIU|rcsb pdb:5EYA|rcsb pdb:5H7S|rcsb pdb:5VNZ|rcsb pdb:5VO0|rcsb pdb:5YWR|rcsb pdb:6D6I|rcsb pdb:6JKY|rcsb pdb:6KFP|rcsb pdb:6KG6|rcsb pdb:6KL4|rcsb pdb:6LP2|rcsb pdb:6P5B|rcsb pdb:6S53|reactome:R-HSA-168927|reactome:R-HSA-202424|reactome:R-HSA-2871837|reactome:R-HSA-445989|reactome:R-HSA-450302|reactome:R-HSA-450321|reactome:R-HSA-5607764|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-5696395|reactome:R-HSA-69473|reactome:R-HSA-8866654|reactome:R-HSA-9020702|reactome:R-HSA-937039|reactome:R-HSA-937041|reactome:R-HSA-9646399|reactome:R-HSA-975110|reactome:R-HSA-975144|reactome:R-HSA-983168|rcsb pdb:6ULH|rcsb pdb:6UMP|rcsb pdb:6UMS|rcsb pdb:7BBD|rcsb pdb:7BBF|rcsb pdb:7BXG|reactome:R-HSA-1169408|reactome:R-HSA-168638	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S2|caution:"UBE2N has been marked as the enzyme in this assay, although it is the UBE2N-UBE2V1 complex that has ubiquitinase (E3) activity. Neither UBE2N nor UBE2V1 have E2 or E3 activity on their own."|resulting-ptm:O43567 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:1TRv4QAAbl5n5VZd2h7OrFpDXKE9606	rogid:dqdszHlq5FLPHC6UWX6uvkC6Yz89606	intact-crc:B205F8F93BDB1EFC|rigid:vzYiH21K1Ft74WrR0jBARQdinMc	false	-	his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P10827	uniprotkb:Q13404	intact:EBI-286285|uniprotkb:P21205|uniprotkb:Q8N6A1|uniprotkb:Q96H73|uniprotkb:A8K3B5|ensembl:ENSP00000264637|ensembl:ENSP00000377679	intact:EBI-1050671|uniprotkb:Q13403|uniprotkb:Q13532|uniprotkb:Q96H34|uniprotkb:Q9GZT0|uniprotkb:Q9GZW1|uniprotkb:Q9H4J3|uniprotkb:Q9H4J4|uniprotkb:Q9UKL1|uniprotkb:Q9UM48|uniprotkb:Q9UM49|uniprotkb:Q9UM50|uniprotkb:Q5TGE3|uniprotkb:E1P629|uniprotkb:Q5TGE0|ensembl:ENSP00000360739	psi-mi:tha_human(display_long)|uniprotkb:Nuclear receptor subfamily 1 group A member 1(gene name synonym)|uniprotkb:EAR7(gene name synonym)|uniprotkb:c-erbA-1(gene name synonym)|uniprotkb:c-erbA-alpha(gene name synonym)|uniprotkb:THRA(gene name)|psi-mi:THRA(display_short)|uniprotkb:ERBA1(gene name synonym)|uniprotkb:NR1A1(gene name synonym)|uniprotkb:THRA1(gene name synonym)|uniprotkb:THRA2(gene name synonym)|uniprotkb:V-erbA-related protein 7(gene name synonym)	psi-mi:ub2v1_human(display_long)|uniprotkb:CROC-1(gene name synonym)|uniprotkb:TRAF6-regulated IKK activator 1 beta Uev1A(gene name synonym)|uniprotkb:P/OKcl.19(orf name)|uniprotkb:UBE2V1(gene name)|psi-mi:UBE2V1(display_short)|uniprotkb:CROC1(gene name synonym)|uniprotkb:UBE2V(gene name synonym)|uniprotkb:UEV1(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9970241|imex:IM-22822-16	author-confidence:Z-score = 3.05	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001177847.1|refseq:NP_001177848.1|refseq:NP_003241.2|refseq:NP_955366.1|dip:DIP-31452N|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001502"(cartilage condensation)|go:"GO:0001503"(ossification)|go:"GO:0002154"(thyroid hormone mediated signaling pathway)|go:"GO:0002155"(regulation of thyroid hormone mediated signaling pathway)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0004879"(nuclear receptor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0007611"(learning or memory)|go:"GO:0008016"(regulation of heart contraction)|go:"GO:0008050"(female courtship behavior)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009409"(response to cold)|go:"GO:0009755"(hormone-mediated signaling pathway)|go:"GO:0017025"(TBP-class protein binding)|go:"GO:0017055"(negative regulation of RNA polymerase II transcription preinitiation complex assembly)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0030878"(thyroid gland development)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0033032"(regulation of myeloid cell apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045925"(positive regulation of female receptivity)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050994"(regulation of lipid catabolic process)|go:"GO:0060509"(type I pneumocyte differentiation)|go:"GO:0070324"(thyroid hormone binding)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:2000143"(negative regulation of DNA-templated transcription, initiation)|interpro:IPR000536(Nuclear hormone receptor, ligand-binding, core)|interpro:IPR001628(Zinc finger, nuclear hormone receptor-type)|interpro:IPR001723(Steroid hormone receptor)|interpro:IPR001728(Thyroid hormone receptor)|interpro:IPR013088(Zinc finger, NHR/GATA-type)|interpro:IPR035500|rcsb pdb:1NAV|rcsb pdb:2H77|rcsb pdb:2H79|rcsb pdb:3HZF|rcsb pdb:3ILZ|rcsb pdb:3JZB|rcsb pdb:4LNW|rcsb pdb:4LNX|reactome:R-HSA-383280|reactome:R-HSA-4090294|ensembl:ENSG00000126351(gene)|ensembl:ENST00000264637(transcript)|ensembl:ENST00000394121(transcript)	refseq:NP_001027459.1|refseq:NP_068823.2|refseq:NP_071887.1|refseq:NP_954595.1|refseq:NP_954673.1|refseq:NP_001244322.1|refseq:NP_001244323.1|refseq:NP_001244325.1|ensembl:ENSG00000244687(gene)|ensembl:ENST00000371674(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006282"(regulation of DNA repair)|go:"GO:0006301"(postreplication repair)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0030154"(cell differentiation)|go:"GO:0031371"(ubiquitin conjugating enzyme complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035370"(UBC13-UEV1A complex)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070534"(protein K63-linked ubiquitination)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|rcsb pdb:2A4D|rcsb pdb:2C2V|rcsb pdb:2HLW|rcsb pdb:6D6I|reactome:R-HSA-168638|reactome:R-HSA-168927|reactome:R-HSA-202424|reactome:R-HSA-2871837|reactome:R-HSA-445989|reactome:R-HSA-450302|reactome:R-HSA-450321|reactome:R-HSA-5607764|reactome:R-HSA-9020702|reactome:R-HSA-937039|reactome:R-HSA-937041|reactome:R-HSA-9646399|reactome:R-HSA-975110|reactome:R-HSA-975144|reactome:R-HSA-983168|dip:DIP-41911N	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S2|caution:"UBE2N has been marked as the enzyme in this assay, although it is the UBE2N-UBE2V1 complex that has ubiquitinase (E3) activity. Neither UBE2N nor UBE2V1 have E2 or E3 activity on their own."|resulting-ptm:P10827 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:u1B3u6XbEyC3OKOWr25s9qZYe4o9606	rogid:x95N7Dj2KIqu5gySX59xLmfthUg9606	intact-crc:E8251E79405E88ED|rigid:zfSIZU0HkduiezXZlCVut5k3a1M	false	-	his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P10827	uniprotkb:P22314	intact:EBI-286285|uniprotkb:P21205|uniprotkb:Q8N6A1|uniprotkb:Q96H73|uniprotkb:A8K3B5|ensembl:ENSP00000264637|ensembl:ENSP00000377679	intact:EBI-709688|uniprotkb:Q96E13|uniprotkb:Q5JRR8|ensembl:ENSP00000338413|ensembl:ENSP00000366568	psi-mi:tha_human(display_long)|uniprotkb:Nuclear receptor subfamily 1 group A member 1(gene name synonym)|uniprotkb:EAR7(gene name synonym)|uniprotkb:c-erbA-1(gene name synonym)|uniprotkb:c-erbA-alpha(gene name synonym)|uniprotkb:THRA(gene name)|psi-mi:THRA(display_short)|uniprotkb:ERBA1(gene name synonym)|uniprotkb:NR1A1(gene name synonym)|uniprotkb:THRA1(gene name synonym)|uniprotkb:THRA2(gene name synonym)|uniprotkb:V-erbA-related protein 7(gene name synonym)	psi-mi:uba1_human(display_long)|uniprotkb:Ubiquitin-activating enzyme E1(gene name synonym)|uniprotkb:Protein A1S9(gene name synonym)|uniprotkb:UBA1(gene name)|psi-mi:UBA1(display_short)|uniprotkb:A1S9T(gene name synonym)|uniprotkb:UBE1(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9970241|imex:IM-22822-16	author-confidence:Z-score = 3.05	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001177847.1|refseq:NP_001177848.1|refseq:NP_003241.2|refseq:NP_955366.1|dip:DIP-31452N|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001502"(cartilage condensation)|go:"GO:0001503"(ossification)|go:"GO:0002154"(thyroid hormone mediated signaling pathway)|go:"GO:0002155"(regulation of thyroid hormone mediated signaling pathway)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0004879"(nuclear receptor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0007611"(learning or memory)|go:"GO:0008016"(regulation of heart contraction)|go:"GO:0008050"(female courtship behavior)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009409"(response to cold)|go:"GO:0009755"(hormone-mediated signaling pathway)|go:"GO:0017025"(TBP-class protein binding)|go:"GO:0017055"(negative regulation of RNA polymerase II transcription preinitiation complex assembly)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0030878"(thyroid gland development)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0033032"(regulation of myeloid cell apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045925"(positive regulation of female receptivity)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050994"(regulation of lipid catabolic process)|go:"GO:0060509"(type I pneumocyte differentiation)|go:"GO:0070324"(thyroid hormone binding)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:2000143"(negative regulation of DNA-templated transcription, initiation)|interpro:IPR000536(Nuclear hormone receptor, ligand-binding, core)|interpro:IPR001628(Zinc finger, nuclear hormone receptor-type)|interpro:IPR001723(Steroid hormone receptor)|interpro:IPR001728(Thyroid hormone receptor)|interpro:IPR013088(Zinc finger, NHR/GATA-type)|interpro:IPR035500|rcsb pdb:1NAV|rcsb pdb:2H77|rcsb pdb:2H79|rcsb pdb:3HZF|rcsb pdb:3ILZ|rcsb pdb:3JZB|rcsb pdb:4LNW|rcsb pdb:4LNX|reactome:R-HSA-383280|reactome:R-HSA-4090294|ensembl:ENSG00000126351(gene)|ensembl:ENST00000264637(transcript)|ensembl:ENST00000394121(transcript)	refseq:NP_003325.2|refseq:NP_695012.1|refseq:XP_016885269.1|refseq:XP_016885270.1|dip:DIP-33686N|ensembl:ENSG00000130985(gene)|ensembl:ENST00000335972(transcript)|ensembl:ENST00000377351(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0004839"(ubiquitin activating enzyme activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0032446"(protein modification by small protein conjugation)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000011(Ubiquitin-activating enzyme, E1)|interpro:IPR000594(UBA/THIF-type NAD/FAD binding fold)|interpro:IPR018074|interpro:IPR018075|interpro:IPR018965|interpro:IPR019572|interpro:IPR032418|interpro:IPR032420|interpro:IPR033127|interpro:IPR035985|interpro:IPR038252|interpro:IPR042063|interpro:IPR042302|interpro:IPR042449|mint:P22314|rcsb pdb:4P22|rcsb pdb:6DC6|reactome:R-HSA-8866652|reactome:R-HSA-983168	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S2|caution:"UBE2N has been marked as the enzyme in this assay, although it is the UBE2N-UBE2V1 complex that has ubiquitinase (E3) activity. Neither UBE2N nor UBE2V1 have E2 or E3 activity on their own."|resulting-ptm:P10827 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:u1B3u6XbEyC3OKOWr25s9qZYe4o9606	rogid:q+vEeA0XLST0Zz173bmEt0dNbDE9606	intact-crc:E8251E79405E88ED|rigid:zfSIZU0HkduiezXZlCVut5k3a1M	false	-	his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P10827	uniprotkb:P61088	intact:EBI-286285|uniprotkb:P21205|uniprotkb:Q8N6A1|uniprotkb:Q96H73|uniprotkb:A8K3B5|ensembl:ENSP00000264637|ensembl:ENSP00000377679	intact:EBI-1052908|uniprotkb:Q16781|uniprotkb:Q53Y81|ensembl:ENSP00000316176	psi-mi:tha_human(display_long)|uniprotkb:Nuclear receptor subfamily 1 group A member 1(gene name synonym)|uniprotkb:EAR7(gene name synonym)|uniprotkb:c-erbA-1(gene name synonym)|uniprotkb:c-erbA-alpha(gene name synonym)|uniprotkb:THRA(gene name)|psi-mi:THRA(display_short)|uniprotkb:ERBA1(gene name synonym)|uniprotkb:NR1A1(gene name synonym)|uniprotkb:THRA1(gene name synonym)|uniprotkb:THRA2(gene name synonym)|uniprotkb:V-erbA-related protein 7(gene name synonym)	psi-mi:ube2n_human(display_long)|uniprotkb:Ubiquitin-protein ligase N(gene name synonym)|uniprotkb:Ubiquitin carrier protein N(gene name synonym)|uniprotkb:Ubc13(gene name synonym)|uniprotkb:Bendless-like ubiquitin-conjugating enzyme(gene name synonym)|uniprotkb:UBE2N(gene name)|psi-mi:UBE2N(display_short)|uniprotkb:BLU(gene name synonym)|uniprotkb:UbcH13(gene name synonym)|uniprotkb:E2 ubiquitin-conjugating enzyme N(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9970241|imex:IM-22822-16	author-confidence:Z-score = 3.05	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001177847.1|refseq:NP_001177848.1|refseq:NP_003241.2|refseq:NP_955366.1|dip:DIP-31452N|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001502"(cartilage condensation)|go:"GO:0001503"(ossification)|go:"GO:0002154"(thyroid hormone mediated signaling pathway)|go:"GO:0002155"(regulation of thyroid hormone mediated signaling pathway)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0004879"(nuclear receptor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0007611"(learning or memory)|go:"GO:0008016"(regulation of heart contraction)|go:"GO:0008050"(female courtship behavior)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009409"(response to cold)|go:"GO:0009755"(hormone-mediated signaling pathway)|go:"GO:0017025"(TBP-class protein binding)|go:"GO:0017055"(negative regulation of RNA polymerase II transcription preinitiation complex assembly)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0030878"(thyroid gland development)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0033032"(regulation of myeloid cell apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045925"(positive regulation of female receptivity)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050994"(regulation of lipid catabolic process)|go:"GO:0060509"(type I pneumocyte differentiation)|go:"GO:0070324"(thyroid hormone binding)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:2000143"(negative regulation of DNA-templated transcription, initiation)|interpro:IPR000536(Nuclear hormone receptor, ligand-binding, core)|interpro:IPR001628(Zinc finger, nuclear hormone receptor-type)|interpro:IPR001723(Steroid hormone receptor)|interpro:IPR001728(Thyroid hormone receptor)|interpro:IPR013088(Zinc finger, NHR/GATA-type)|interpro:IPR035500|rcsb pdb:1NAV|rcsb pdb:2H77|rcsb pdb:2H79|rcsb pdb:3HZF|rcsb pdb:3ILZ|rcsb pdb:3JZB|rcsb pdb:4LNW|rcsb pdb:4LNX|reactome:R-HSA-383280|reactome:R-HSA-4090294|ensembl:ENSG00000126351(gene)|ensembl:ENST00000264637(transcript)|ensembl:ENST00000394121(transcript)	refseq:NP_003339.1|dip:DIP-29829N|ensembl:ENSG00000177889(gene)|ensembl:ENST00000318066(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000729"(DNA double-strand break processing)|go:"GO:0001650"(fibrillar center)|go:"GO:0003723"(RNA binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006282"(regulation of DNA repair)|go:"GO:0006301"(postreplication repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016574"(histone ubiquitination)|go:"GO:0031058"(positive regulation of histone modification)|go:"GO:0031372"(UBC13-MMS2 complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033182"(regulation of histone ubiquitination)|go:"GO:0035370"(UBC13-UEV1A complex)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0061631"(ubiquitin conjugating enzyme activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070534"(protein K63-linked ubiquitination)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|interpro:IPR023313|rcsb pdb:1J7D|rcsb pdb:2C2V|rcsb pdb:3HCT|rcsb pdb:3HCU|rcsb pdb:3VON|rcsb pdb:3W31|rcsb pdb:4DHI|rcsb pdb:4DHJ|rcsb pdb:4DHZ|rcsb pdb:4IP3|rcsb pdb:4NR3|rcsb pdb:4NRG|rcsb pdb:4NRI|rcsb pdb:4ONL|rcsb pdb:4ONM|rcsb pdb:4ONN|rcsb pdb:4ORH|rcsb pdb:4TKP|rcsb pdb:4WHV|rcsb pdb:5AIT|rcsb pdb:5AIU|rcsb pdb:5EYA|rcsb pdb:5H7S|rcsb pdb:5VNZ|rcsb pdb:5VO0|rcsb pdb:5YWR|rcsb pdb:6D6I|rcsb pdb:6JKY|rcsb pdb:6KFP|rcsb pdb:6KG6|rcsb pdb:6KL4|rcsb pdb:6LP2|rcsb pdb:6P5B|rcsb pdb:6S53|reactome:R-HSA-168927|reactome:R-HSA-202424|reactome:R-HSA-2871837|reactome:R-HSA-445989|reactome:R-HSA-450302|reactome:R-HSA-450321|reactome:R-HSA-5607764|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-5696395|reactome:R-HSA-69473|reactome:R-HSA-8866654|reactome:R-HSA-9020702|reactome:R-HSA-937039|reactome:R-HSA-937041|reactome:R-HSA-9646399|reactome:R-HSA-975110|reactome:R-HSA-975144|reactome:R-HSA-983168|rcsb pdb:6ULH|rcsb pdb:6UMP|rcsb pdb:6UMS|rcsb pdb:7BBD|rcsb pdb:7BBF|rcsb pdb:7BXG|reactome:R-HSA-1169408|reactome:R-HSA-168638	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S2|caution:"UBE2N has been marked as the enzyme in this assay, although it is the UBE2N-UBE2V1 complex that has ubiquitinase (E3) activity. Neither UBE2N nor UBE2V1 have E2 or E3 activity on their own."|resulting-ptm:P10827 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:u1B3u6XbEyC3OKOWr25s9qZYe4o9606	rogid:dqdszHlq5FLPHC6UWX6uvkC6Yz89606	intact-crc:E8251E79405E88ED|rigid:zfSIZU0HkduiezXZlCVut5k3a1M	false	-	his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P19474	uniprotkb:Q13404	intact:EBI-81290|uniprotkb:Q96RF8|uniprotkb:Q5XPV5|ensembl:ENSP00000254436	intact:EBI-1050671|uniprotkb:Q13403|uniprotkb:Q13532|uniprotkb:Q96H34|uniprotkb:Q9GZT0|uniprotkb:Q9GZW1|uniprotkb:Q9H4J3|uniprotkb:Q9H4J4|uniprotkb:Q9UKL1|uniprotkb:Q9UM48|uniprotkb:Q9UM49|uniprotkb:Q9UM50|uniprotkb:Q5TGE3|uniprotkb:E1P629|uniprotkb:Q5TGE0|ensembl:ENSP00000360739	psi-mi:ro52_human(display_long)|uniprotkb:TRIM21(gene name)|psi-mi:TRIM21(display_short)|uniprotkb:RNF81(gene name synonym)|uniprotkb:Sjoegren syndrome type A antigen(gene name synonym)|uniprotkb:"Ro(SS-A)"(gene name synonym)|uniprotkb:52 kDa ribonucleoprotein autoantigen Ro/SS-A(gene name synonym)|uniprotkb:Tripartite motif-containing protein 21(gene name synonym)|uniprotkb:RING finger protein 81(gene name synonym)|uniprotkb:52 kDa Ro protein(gene name synonym)|uniprotkb:RO52(gene name synonym)|uniprotkb:SSA1(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase TRIM21(gene name synonym)	psi-mi:ub2v1_human(display_long)|uniprotkb:CROC-1(gene name synonym)|uniprotkb:TRAF6-regulated IKK activator 1 beta Uev1A(gene name synonym)|uniprotkb:P/OKcl.19(orf name)|uniprotkb:UBE2V1(gene name)|psi-mi:UBE2V1(display_short)|uniprotkb:CROC1(gene name synonym)|uniprotkb:UBE2V(gene name synonym)|uniprotkb:UEV1(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9970262|imex:IM-22822-17	author-confidence:Z-score = 14.14	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_003132.2|go:"GO:0019901"(protein kinase binding)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031648"(protein destabilization)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032479"(regulation of type I interferon production)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0032897"(negative regulation of viral transcription)|go:"GO:0034341"(response to interferon-gamma)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045087"(innate immune response)|go:"GO:0045787"(positive regulation of cell cycle)|go:"GO:0045824"(negative regulation of innate immune response)|go:"GO:0046596"(regulation of viral entry into host cell)|go:"GO:0046598"(positive regulation of viral entry into host cell)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0090086"(negative regulation of protein deubiquitination)|ensembl:ENSG00000132109(gene)|ensembl:ENST00000254436(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000932"(P-body)|go:"GO:0003677"(DNA binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003723"(RNA binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005776"(autophagosome)|go:"GO:0005829"(cytosol)|go:"GO:0006513"(protein monoubiquitination)|go:"GO:0007049"(cell cycle)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0016567"(protein ubiquitination)|interpro:IPR006574(SPRY-associated)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR017907|interpro:IPR020457|interpro:IPR035831|interpro:IPR043136|mint:P19474|rcsb pdb:2IWG|rcsb pdb:5JPX|rcsb pdb:5OLM|rcsb pdb:6FGA|rcsb pdb:6S53|rcsb pdb:7BBD|reactome:R-HSA-1834941|reactome:R-HSA-3134975|reactome:R-HSA-877300|reactome:R-HSA-983168|go:"GO:1902187"|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR000315(Zinc finger, B-box)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR001870("B302 (SPRY)-like")|interpro:IPR003613(U box)|interpro:IPR003877(SPla/RYanodine receptor SPRY)|interpro:IPR003879(Butyrophylin-like)	refseq:NP_001027459.1|refseq:NP_068823.2|refseq:NP_071887.1|refseq:NP_954595.1|refseq:NP_954673.1|refseq:NP_001244322.1|refseq:NP_001244323.1|refseq:NP_001244325.1|ensembl:ENSG00000244687(gene)|ensembl:ENST00000371674(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006282"(regulation of DNA repair)|go:"GO:0006301"(postreplication repair)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0030154"(cell differentiation)|go:"GO:0031371"(ubiquitin conjugating enzyme complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035370"(UBC13-UEV1A complex)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070534"(protein K63-linked ubiquitination)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|rcsb pdb:2A4D|rcsb pdb:2C2V|rcsb pdb:2HLW|rcsb pdb:6D6I|reactome:R-HSA-168638|reactome:R-HSA-168927|reactome:R-HSA-202424|reactome:R-HSA-2871837|reactome:R-HSA-445989|reactome:R-HSA-450302|reactome:R-HSA-450321|reactome:R-HSA-5607764|reactome:R-HSA-9020702|reactome:R-HSA-937039|reactome:R-HSA-937041|reactome:R-HSA-9646399|reactome:R-HSA-975110|reactome:R-HSA-975144|reactome:R-HSA-983168|dip:DIP-41911N	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S2|caution:"UBE2N has been marked as the enzyme in this assay, although it is the UBE2N-UBE2V1 complex that has ubiquitinase (E3) activity. Neither UBE2N nor UBE2V1 have E2 or E3 activity on their own."|resulting-ptm:P19474 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:/9rpwdudXQWv8z8JLmRecXf3YQM9606	rogid:x95N7Dj2KIqu5gySX59xLmfthUg9606	intact-crc:7142CC9480BF6D23|rigid:N3pwVavYiJicxym9n10tj2BQZCA	false	-	his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P19474	uniprotkb:P22314	intact:EBI-81290|uniprotkb:Q96RF8|uniprotkb:Q5XPV5|ensembl:ENSP00000254436	intact:EBI-709688|uniprotkb:Q96E13|uniprotkb:Q5JRR8|ensembl:ENSP00000338413|ensembl:ENSP00000366568	psi-mi:ro52_human(display_long)|uniprotkb:TRIM21(gene name)|psi-mi:TRIM21(display_short)|uniprotkb:RNF81(gene name synonym)|uniprotkb:Sjoegren syndrome type A antigen(gene name synonym)|uniprotkb:"Ro(SS-A)"(gene name synonym)|uniprotkb:52 kDa ribonucleoprotein autoantigen Ro/SS-A(gene name synonym)|uniprotkb:Tripartite motif-containing protein 21(gene name synonym)|uniprotkb:RING finger protein 81(gene name synonym)|uniprotkb:52 kDa Ro protein(gene name synonym)|uniprotkb:RO52(gene name synonym)|uniprotkb:SSA1(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase TRIM21(gene name synonym)	psi-mi:uba1_human(display_long)|uniprotkb:Ubiquitin-activating enzyme E1(gene name synonym)|uniprotkb:Protein A1S9(gene name synonym)|uniprotkb:UBA1(gene name)|psi-mi:UBA1(display_short)|uniprotkb:A1S9T(gene name synonym)|uniprotkb:UBE1(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9970262|imex:IM-22822-17	author-confidence:Z-score = 14.14	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_003132.2|go:"GO:0019901"(protein kinase binding)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031648"(protein destabilization)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032479"(regulation of type I interferon production)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0032897"(negative regulation of viral transcription)|go:"GO:0034341"(response to interferon-gamma)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045087"(innate immune response)|go:"GO:0045787"(positive regulation of cell cycle)|go:"GO:0045824"(negative regulation of innate immune response)|go:"GO:0046596"(regulation of viral entry into host cell)|go:"GO:0046598"(positive regulation of viral entry into host cell)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0090086"(negative regulation of protein deubiquitination)|ensembl:ENSG00000132109(gene)|ensembl:ENST00000254436(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000932"(P-body)|go:"GO:0003677"(DNA binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003723"(RNA binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005776"(autophagosome)|go:"GO:0005829"(cytosol)|go:"GO:0006513"(protein monoubiquitination)|go:"GO:0007049"(cell cycle)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0016567"(protein ubiquitination)|interpro:IPR006574(SPRY-associated)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR017907|interpro:IPR020457|interpro:IPR035831|interpro:IPR043136|mint:P19474|rcsb pdb:2IWG|rcsb pdb:5JPX|rcsb pdb:5OLM|rcsb pdb:6FGA|rcsb pdb:6S53|rcsb pdb:7BBD|reactome:R-HSA-1834941|reactome:R-HSA-3134975|reactome:R-HSA-877300|reactome:R-HSA-983168|go:"GO:1902187"|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR000315(Zinc finger, B-box)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR001870("B302 (SPRY)-like")|interpro:IPR003613(U box)|interpro:IPR003877(SPla/RYanodine receptor SPRY)|interpro:IPR003879(Butyrophylin-like)	refseq:NP_003325.2|refseq:NP_695012.1|refseq:XP_016885269.1|refseq:XP_016885270.1|dip:DIP-33686N|ensembl:ENSG00000130985(gene)|ensembl:ENST00000335972(transcript)|ensembl:ENST00000377351(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0004839"(ubiquitin activating enzyme activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0032446"(protein modification by small protein conjugation)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000011(Ubiquitin-activating enzyme, E1)|interpro:IPR000594(UBA/THIF-type NAD/FAD binding fold)|interpro:IPR018074|interpro:IPR018075|interpro:IPR018965|interpro:IPR019572|interpro:IPR032418|interpro:IPR032420|interpro:IPR033127|interpro:IPR035985|interpro:IPR038252|interpro:IPR042063|interpro:IPR042302|interpro:IPR042449|mint:P22314|rcsb pdb:4P22|rcsb pdb:6DC6|reactome:R-HSA-8866652|reactome:R-HSA-983168	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S2|caution:"UBE2N has been marked as the enzyme in this assay, although it is the UBE2N-UBE2V1 complex that has ubiquitinase (E3) activity. Neither UBE2N nor UBE2V1 have E2 or E3 activity on their own."|resulting-ptm:P19474 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:/9rpwdudXQWv8z8JLmRecXf3YQM9606	rogid:q+vEeA0XLST0Zz173bmEt0dNbDE9606	intact-crc:7142CC9480BF6D23|rigid:N3pwVavYiJicxym9n10tj2BQZCA	false	-	his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P19474	uniprotkb:P61088	intact:EBI-81290|uniprotkb:Q96RF8|uniprotkb:Q5XPV5|ensembl:ENSP00000254436	intact:EBI-1052908|uniprotkb:Q16781|uniprotkb:Q53Y81|ensembl:ENSP00000316176	psi-mi:ro52_human(display_long)|uniprotkb:TRIM21(gene name)|psi-mi:TRIM21(display_short)|uniprotkb:RNF81(gene name synonym)|uniprotkb:Sjoegren syndrome type A antigen(gene name synonym)|uniprotkb:"Ro(SS-A)"(gene name synonym)|uniprotkb:52 kDa ribonucleoprotein autoantigen Ro/SS-A(gene name synonym)|uniprotkb:Tripartite motif-containing protein 21(gene name synonym)|uniprotkb:RING finger protein 81(gene name synonym)|uniprotkb:52 kDa Ro protein(gene name synonym)|uniprotkb:RO52(gene name synonym)|uniprotkb:SSA1(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase TRIM21(gene name synonym)	psi-mi:ube2n_human(display_long)|uniprotkb:Ubiquitin-protein ligase N(gene name synonym)|uniprotkb:Ubiquitin carrier protein N(gene name synonym)|uniprotkb:Ubc13(gene name synonym)|uniprotkb:Bendless-like ubiquitin-conjugating enzyme(gene name synonym)|uniprotkb:UBE2N(gene name)|psi-mi:UBE2N(display_short)|uniprotkb:BLU(gene name synonym)|uniprotkb:UbcH13(gene name synonym)|uniprotkb:E2 ubiquitin-conjugating enzyme N(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9970262|imex:IM-22822-17	author-confidence:Z-score = 14.14	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_003132.2|go:"GO:0019901"(protein kinase binding)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031648"(protein destabilization)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032479"(regulation of type I interferon production)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0032897"(negative regulation of viral transcription)|go:"GO:0034341"(response to interferon-gamma)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045087"(innate immune response)|go:"GO:0045787"(positive regulation of cell cycle)|go:"GO:0045824"(negative regulation of innate immune response)|go:"GO:0046596"(regulation of viral entry into host cell)|go:"GO:0046598"(positive regulation of viral entry into host cell)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0090086"(negative regulation of protein deubiquitination)|ensembl:ENSG00000132109(gene)|ensembl:ENST00000254436(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000932"(P-body)|go:"GO:0003677"(DNA binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003723"(RNA binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005776"(autophagosome)|go:"GO:0005829"(cytosol)|go:"GO:0006513"(protein monoubiquitination)|go:"GO:0007049"(cell cycle)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0016567"(protein ubiquitination)|interpro:IPR006574(SPRY-associated)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR017907|interpro:IPR020457|interpro:IPR035831|interpro:IPR043136|mint:P19474|rcsb pdb:2IWG|rcsb pdb:5JPX|rcsb pdb:5OLM|rcsb pdb:6FGA|rcsb pdb:6S53|rcsb pdb:7BBD|reactome:R-HSA-1834941|reactome:R-HSA-3134975|reactome:R-HSA-877300|reactome:R-HSA-983168|go:"GO:1902187"|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR000315(Zinc finger, B-box)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR001870("B302 (SPRY)-like")|interpro:IPR003613(U box)|interpro:IPR003877(SPla/RYanodine receptor SPRY)|interpro:IPR003879(Butyrophylin-like)	refseq:NP_003339.1|dip:DIP-29829N|ensembl:ENSG00000177889(gene)|ensembl:ENST00000318066(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000729"(DNA double-strand break processing)|go:"GO:0001650"(fibrillar center)|go:"GO:0003723"(RNA binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006282"(regulation of DNA repair)|go:"GO:0006301"(postreplication repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016574"(histone ubiquitination)|go:"GO:0031058"(positive regulation of histone modification)|go:"GO:0031372"(UBC13-MMS2 complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033182"(regulation of histone ubiquitination)|go:"GO:0035370"(UBC13-UEV1A complex)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0061631"(ubiquitin conjugating enzyme activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070534"(protein K63-linked ubiquitination)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|interpro:IPR023313|rcsb pdb:1J7D|rcsb pdb:2C2V|rcsb pdb:3HCT|rcsb pdb:3HCU|rcsb pdb:3VON|rcsb pdb:3W31|rcsb pdb:4DHI|rcsb pdb:4DHJ|rcsb pdb:4DHZ|rcsb pdb:4IP3|rcsb pdb:4NR3|rcsb pdb:4NRG|rcsb pdb:4NRI|rcsb pdb:4ONL|rcsb pdb:4ONM|rcsb pdb:4ONN|rcsb pdb:4ORH|rcsb pdb:4TKP|rcsb pdb:4WHV|rcsb pdb:5AIT|rcsb pdb:5AIU|rcsb pdb:5EYA|rcsb pdb:5H7S|rcsb pdb:5VNZ|rcsb pdb:5VO0|rcsb pdb:5YWR|rcsb pdb:6D6I|rcsb pdb:6JKY|rcsb pdb:6KFP|rcsb pdb:6KG6|rcsb pdb:6KL4|rcsb pdb:6LP2|rcsb pdb:6P5B|rcsb pdb:6S53|reactome:R-HSA-168927|reactome:R-HSA-202424|reactome:R-HSA-2871837|reactome:R-HSA-445989|reactome:R-HSA-450302|reactome:R-HSA-450321|reactome:R-HSA-5607764|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-5696395|reactome:R-HSA-69473|reactome:R-HSA-8866654|reactome:R-HSA-9020702|reactome:R-HSA-937039|reactome:R-HSA-937041|reactome:R-HSA-9646399|reactome:R-HSA-975110|reactome:R-HSA-975144|reactome:R-HSA-983168|rcsb pdb:6ULH|rcsb pdb:6UMP|rcsb pdb:6UMS|rcsb pdb:7BBD|rcsb pdb:7BBF|rcsb pdb:7BXG|reactome:R-HSA-1169408|reactome:R-HSA-168638	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S2|caution:"UBE2N has been marked as the enzyme in this assay, although it is the UBE2N-UBE2V1 complex that has ubiquitinase (E3) activity. Neither UBE2N nor UBE2V1 have E2 or E3 activity on their own."|resulting-ptm:P19474 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:/9rpwdudXQWv8z8JLmRecXf3YQM9606	rogid:dqdszHlq5FLPHC6UWX6uvkC6Yz89606	intact-crc:7142CC9480BF6D23|rigid:N3pwVavYiJicxym9n10tj2BQZCA	false	-	his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q13404	uniprotkb:P22314	intact:EBI-1050671|uniprotkb:Q13403|uniprotkb:Q13532|uniprotkb:Q96H34|uniprotkb:Q9GZT0|uniprotkb:Q9GZW1|uniprotkb:Q9H4J3|uniprotkb:Q9H4J4|uniprotkb:Q9UKL1|uniprotkb:Q9UM48|uniprotkb:Q9UM49|uniprotkb:Q9UM50|uniprotkb:Q5TGE3|uniprotkb:E1P629|uniprotkb:Q5TGE0|ensembl:ENSP00000360739	intact:EBI-709688|uniprotkb:Q96E13|uniprotkb:Q5JRR8|ensembl:ENSP00000338413|ensembl:ENSP00000366568	psi-mi:ub2v1_human(display_long)|uniprotkb:CROC-1(gene name synonym)|uniprotkb:TRAF6-regulated IKK activator 1 beta Uev1A(gene name synonym)|uniprotkb:P/OKcl.19(orf name)|uniprotkb:UBE2V1(gene name)|psi-mi:UBE2V1(display_short)|uniprotkb:CROC1(gene name synonym)|uniprotkb:UBE2V(gene name synonym)|uniprotkb:UEV1(gene name synonym)	psi-mi:uba1_human(display_long)|uniprotkb:Ubiquitin-activating enzyme E1(gene name synonym)|uniprotkb:Protein A1S9(gene name synonym)|uniprotkb:UBA1(gene name)|psi-mi:UBA1(display_short)|uniprotkb:A1S9T(gene name synonym)|uniprotkb:UBE1(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9970283|imex:IM-22822-18	author-confidence:Z-score = 4.13	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001027459.1|refseq:NP_068823.2|refseq:NP_071887.1|refseq:NP_954595.1|refseq:NP_954673.1|refseq:NP_001244322.1|refseq:NP_001244323.1|refseq:NP_001244325.1|ensembl:ENSG00000244687(gene)|ensembl:ENST00000371674(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006282"(regulation of DNA repair)|go:"GO:0006301"(postreplication repair)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0030154"(cell differentiation)|go:"GO:0031371"(ubiquitin conjugating enzyme complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035370"(UBC13-UEV1A complex)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070534"(protein K63-linked ubiquitination)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|rcsb pdb:2A4D|rcsb pdb:2C2V|rcsb pdb:2HLW|rcsb pdb:6D6I|reactome:R-HSA-168638|reactome:R-HSA-168927|reactome:R-HSA-202424|reactome:R-HSA-2871837|reactome:R-HSA-445989|reactome:R-HSA-450302|reactome:R-HSA-450321|reactome:R-HSA-5607764|reactome:R-HSA-9020702|reactome:R-HSA-937039|reactome:R-HSA-937041|reactome:R-HSA-9646399|reactome:R-HSA-975110|reactome:R-HSA-975144|reactome:R-HSA-983168|dip:DIP-41911N	refseq:NP_003325.2|refseq:NP_695012.1|refseq:XP_016885269.1|refseq:XP_016885270.1|dip:DIP-33686N|ensembl:ENSG00000130985(gene)|ensembl:ENST00000335972(transcript)|ensembl:ENST00000377351(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0004839"(ubiquitin activating enzyme activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0032446"(protein modification by small protein conjugation)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000011(Ubiquitin-activating enzyme, E1)|interpro:IPR000594(UBA/THIF-type NAD/FAD binding fold)|interpro:IPR018074|interpro:IPR018075|interpro:IPR018965|interpro:IPR019572|interpro:IPR032418|interpro:IPR032420|interpro:IPR033127|interpro:IPR035985|interpro:IPR038252|interpro:IPR042063|interpro:IPR042302|interpro:IPR042449|mint:P22314|rcsb pdb:4P22|rcsb pdb:6DC6|reactome:R-HSA-8866652|reactome:R-HSA-983168	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S2|caution:"UBE2N has been marked as the enzyme in this assay, although it is the UBE2N-UBE2V1 complex that has ubiquitinase (E3) activity. Neither UBE2N nor UBE2V1 have E2 or E3 activity on their own."|resulting-ptm:P22314 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:x95N7Dj2KIqu5gySX59xLmfthUg9606	rogid:q+vEeA0XLST0Zz173bmEt0dNbDE9606	intact-crc:FF928B41D50538E4|rigid:5BdiTaDz1gKqSquhKpUmE3M2xmk	false	his tag:?-?	his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q13404	uniprotkb:P22314	intact:EBI-1050671|uniprotkb:Q13403|uniprotkb:Q13532|uniprotkb:Q96H34|uniprotkb:Q9GZT0|uniprotkb:Q9GZW1|uniprotkb:Q9H4J3|uniprotkb:Q9H4J4|uniprotkb:Q9UKL1|uniprotkb:Q9UM48|uniprotkb:Q9UM49|uniprotkb:Q9UM50|uniprotkb:Q5TGE3|uniprotkb:E1P629|uniprotkb:Q5TGE0|ensembl:ENSP00000360739	intact:EBI-709688|uniprotkb:Q96E13|uniprotkb:Q5JRR8|ensembl:ENSP00000338413|ensembl:ENSP00000366568	psi-mi:ub2v1_human(display_long)|uniprotkb:CROC-1(gene name synonym)|uniprotkb:TRAF6-regulated IKK activator 1 beta Uev1A(gene name synonym)|uniprotkb:P/OKcl.19(orf name)|uniprotkb:UBE2V1(gene name)|psi-mi:UBE2V1(display_short)|uniprotkb:CROC1(gene name synonym)|uniprotkb:UBE2V(gene name synonym)|uniprotkb:UEV1(gene name synonym)	psi-mi:uba1_human(display_long)|uniprotkb:Ubiquitin-activating enzyme E1(gene name synonym)|uniprotkb:Protein A1S9(gene name synonym)|uniprotkb:UBA1(gene name)|psi-mi:UBA1(display_short)|uniprotkb:A1S9T(gene name synonym)|uniprotkb:UBE1(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9970283|imex:IM-22822-18	author-confidence:Z-score = 4.13	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001027459.1|refseq:NP_068823.2|refseq:NP_071887.1|refseq:NP_954595.1|refseq:NP_954673.1|refseq:NP_001244322.1|refseq:NP_001244323.1|refseq:NP_001244325.1|ensembl:ENSG00000244687(gene)|ensembl:ENST00000371674(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006282"(regulation of DNA repair)|go:"GO:0006301"(postreplication repair)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0030154"(cell differentiation)|go:"GO:0031371"(ubiquitin conjugating enzyme complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035370"(UBC13-UEV1A complex)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070534"(protein K63-linked ubiquitination)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|rcsb pdb:2A4D|rcsb pdb:2C2V|rcsb pdb:2HLW|rcsb pdb:6D6I|reactome:R-HSA-168638|reactome:R-HSA-168927|reactome:R-HSA-202424|reactome:R-HSA-2871837|reactome:R-HSA-445989|reactome:R-HSA-450302|reactome:R-HSA-450321|reactome:R-HSA-5607764|reactome:R-HSA-9020702|reactome:R-HSA-937039|reactome:R-HSA-937041|reactome:R-HSA-9646399|reactome:R-HSA-975110|reactome:R-HSA-975144|reactome:R-HSA-983168|dip:DIP-41911N	refseq:NP_003325.2|refseq:NP_695012.1|refseq:XP_016885269.1|refseq:XP_016885270.1|dip:DIP-33686N|ensembl:ENSG00000130985(gene)|ensembl:ENST00000335972(transcript)|ensembl:ENST00000377351(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0004839"(ubiquitin activating enzyme activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0032446"(protein modification by small protein conjugation)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000011(Ubiquitin-activating enzyme, E1)|interpro:IPR000594(UBA/THIF-type NAD/FAD binding fold)|interpro:IPR018074|interpro:IPR018075|interpro:IPR018965|interpro:IPR019572|interpro:IPR032418|interpro:IPR032420|interpro:IPR033127|interpro:IPR035985|interpro:IPR038252|interpro:IPR042063|interpro:IPR042302|interpro:IPR042449|mint:P22314|rcsb pdb:4P22|rcsb pdb:6DC6|reactome:R-HSA-8866652|reactome:R-HSA-983168	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S2|caution:"UBE2N has been marked as the enzyme in this assay, although it is the UBE2N-UBE2V1 complex that has ubiquitinase (E3) activity. Neither UBE2N nor UBE2V1 have E2 or E3 activity on their own."|resulting-ptm:P22314 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:x95N7Dj2KIqu5gySX59xLmfthUg9606	rogid:q+vEeA0XLST0Zz173bmEt0dNbDE9606	intact-crc:FF928B41D50538E4|rigid:5BdiTaDz1gKqSquhKpUmE3M2xmk	false	his tag:?-?	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q13404	uniprotkb:P61088	intact:EBI-1050671|uniprotkb:Q13403|uniprotkb:Q13532|uniprotkb:Q96H34|uniprotkb:Q9GZT0|uniprotkb:Q9GZW1|uniprotkb:Q9H4J3|uniprotkb:Q9H4J4|uniprotkb:Q9UKL1|uniprotkb:Q9UM48|uniprotkb:Q9UM49|uniprotkb:Q9UM50|uniprotkb:Q5TGE3|uniprotkb:E1P629|uniprotkb:Q5TGE0|ensembl:ENSP00000360739	intact:EBI-1052908|uniprotkb:Q16781|uniprotkb:Q53Y81|ensembl:ENSP00000316176	psi-mi:ub2v1_human(display_long)|uniprotkb:CROC-1(gene name synonym)|uniprotkb:TRAF6-regulated IKK activator 1 beta Uev1A(gene name synonym)|uniprotkb:P/OKcl.19(orf name)|uniprotkb:UBE2V1(gene name)|psi-mi:UBE2V1(display_short)|uniprotkb:CROC1(gene name synonym)|uniprotkb:UBE2V(gene name synonym)|uniprotkb:UEV1(gene name synonym)	psi-mi:ube2n_human(display_long)|uniprotkb:Ubiquitin-protein ligase N(gene name synonym)|uniprotkb:Ubiquitin carrier protein N(gene name synonym)|uniprotkb:Ubc13(gene name synonym)|uniprotkb:Bendless-like ubiquitin-conjugating enzyme(gene name synonym)|uniprotkb:UBE2N(gene name)|psi-mi:UBE2N(display_short)|uniprotkb:BLU(gene name synonym)|uniprotkb:UbcH13(gene name synonym)|uniprotkb:E2 ubiquitin-conjugating enzyme N(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9970283|imex:IM-22822-18	author-confidence:Z-score = 4.13	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001027459.1|refseq:NP_068823.2|refseq:NP_071887.1|refseq:NP_954595.1|refseq:NP_954673.1|refseq:NP_001244322.1|refseq:NP_001244323.1|refseq:NP_001244325.1|ensembl:ENSG00000244687(gene)|ensembl:ENST00000371674(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006282"(regulation of DNA repair)|go:"GO:0006301"(postreplication repair)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0030154"(cell differentiation)|go:"GO:0031371"(ubiquitin conjugating enzyme complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035370"(UBC13-UEV1A complex)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070534"(protein K63-linked ubiquitination)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|rcsb pdb:2A4D|rcsb pdb:2C2V|rcsb pdb:2HLW|rcsb pdb:6D6I|reactome:R-HSA-168638|reactome:R-HSA-168927|reactome:R-HSA-202424|reactome:R-HSA-2871837|reactome:R-HSA-445989|reactome:R-HSA-450302|reactome:R-HSA-450321|reactome:R-HSA-5607764|reactome:R-HSA-9020702|reactome:R-HSA-937039|reactome:R-HSA-937041|reactome:R-HSA-9646399|reactome:R-HSA-975110|reactome:R-HSA-975144|reactome:R-HSA-983168|dip:DIP-41911N	refseq:NP_003339.1|dip:DIP-29829N|ensembl:ENSG00000177889(gene)|ensembl:ENST00000318066(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000729"(DNA double-strand break processing)|go:"GO:0001650"(fibrillar center)|go:"GO:0003723"(RNA binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006282"(regulation of DNA repair)|go:"GO:0006301"(postreplication repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016574"(histone ubiquitination)|go:"GO:0031058"(positive regulation of histone modification)|go:"GO:0031372"(UBC13-MMS2 complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033182"(regulation of histone ubiquitination)|go:"GO:0035370"(UBC13-UEV1A complex)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0061631"(ubiquitin conjugating enzyme activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070534"(protein K63-linked ubiquitination)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|interpro:IPR023313|rcsb pdb:1J7D|rcsb pdb:2C2V|rcsb pdb:3HCT|rcsb pdb:3HCU|rcsb pdb:3VON|rcsb pdb:3W31|rcsb pdb:4DHI|rcsb pdb:4DHJ|rcsb pdb:4DHZ|rcsb pdb:4IP3|rcsb pdb:4NR3|rcsb pdb:4NRG|rcsb pdb:4NRI|rcsb pdb:4ONL|rcsb pdb:4ONM|rcsb pdb:4ONN|rcsb pdb:4ORH|rcsb pdb:4TKP|rcsb pdb:4WHV|rcsb pdb:5AIT|rcsb pdb:5AIU|rcsb pdb:5EYA|rcsb pdb:5H7S|rcsb pdb:5VNZ|rcsb pdb:5VO0|rcsb pdb:5YWR|rcsb pdb:6D6I|rcsb pdb:6JKY|rcsb pdb:6KFP|rcsb pdb:6KG6|rcsb pdb:6KL4|rcsb pdb:6LP2|rcsb pdb:6P5B|rcsb pdb:6S53|reactome:R-HSA-168927|reactome:R-HSA-202424|reactome:R-HSA-2871837|reactome:R-HSA-445989|reactome:R-HSA-450302|reactome:R-HSA-450321|reactome:R-HSA-5607764|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-5696395|reactome:R-HSA-69473|reactome:R-HSA-8866654|reactome:R-HSA-9020702|reactome:R-HSA-937039|reactome:R-HSA-937041|reactome:R-HSA-9646399|reactome:R-HSA-975110|reactome:R-HSA-975144|reactome:R-HSA-983168|rcsb pdb:6ULH|rcsb pdb:6UMP|rcsb pdb:6UMS|rcsb pdb:7BBD|rcsb pdb:7BBF|rcsb pdb:7BXG|reactome:R-HSA-1169408|reactome:R-HSA-168638	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S2|caution:"UBE2N has been marked as the enzyme in this assay, although it is the UBE2N-UBE2V1 complex that has ubiquitinase (E3) activity. Neither UBE2N nor UBE2V1 have E2 or E3 activity on their own."|resulting-ptm:P22314 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:x95N7Dj2KIqu5gySX59xLmfthUg9606	rogid:dqdszHlq5FLPHC6UWX6uvkC6Yz89606	intact-crc:FF928B41D50538E4|rigid:5BdiTaDz1gKqSquhKpUmE3M2xmk	false	his tag:?-?	his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P50120	uniprotkb:Q13404	intact:EBI-9915923|uniprotkb:Q6ISQ9|uniprotkb:A8K7G3|uniprotkb:Q6ISS7|ensembl:ENSP00000232217	intact:EBI-1050671|uniprotkb:Q13403|uniprotkb:Q13532|uniprotkb:Q96H34|uniprotkb:Q9GZT0|uniprotkb:Q9GZW1|uniprotkb:Q9H4J3|uniprotkb:Q9H4J4|uniprotkb:Q9UKL1|uniprotkb:Q9UM48|uniprotkb:Q9UM49|uniprotkb:Q9UM50|uniprotkb:Q5TGE3|uniprotkb:E1P629|uniprotkb:Q5TGE0|ensembl:ENSP00000360739	psi-mi:ret2_human(display_long)|uniprotkb:CRBP2(gene name synonym)|uniprotkb:Cellular retinol-binding protein II(gene name synonym)|uniprotkb:RBP2(gene name)|psi-mi:RBP2(display_short)	psi-mi:ub2v1_human(display_long)|uniprotkb:CROC-1(gene name synonym)|uniprotkb:TRAF6-regulated IKK activator 1 beta Uev1A(gene name synonym)|uniprotkb:P/OKcl.19(orf name)|uniprotkb:UBE2V1(gene name)|psi-mi:UBE2V1(display_short)|uniprotkb:CROC1(gene name synonym)|uniprotkb:UBE2V(gene name synonym)|uniprotkb:UEV1(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9970325|imex:IM-22822-20	author-confidence:Z-score = 3.18	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_004155.2|ensembl:ENSG00000114113(gene)|ensembl:ENST00000232217(transcript)|go:"GO:0005501"(retinoid binding)|go:"GO:0005829"(cytosol)|go:"GO:0006776"(vitamin A metabolic process)|go:"GO:0008544"(epidermis development)|go:"GO:0016918"(retinal binding)|go:"GO:0019841"(retinol binding)|interpro:IPR000463(Cytosolic fatty-acid binding)|interpro:IPR000566(Lipocalin-related protein and Bos/Can/Equ allergen)|interpro:IPR012674(Calycin)|interpro:IPR031259|rcsb pdb:2RCQ|rcsb pdb:2RCT|rcsb pdb:4EDE|rcsb pdb:4EFG|rcsb pdb:4EXZ|rcsb pdb:4GKC|rcsb pdb:4QYN|rcsb pdb:4QYP|rcsb pdb:4QZT|rcsb pdb:4QZU|rcsb pdb:4RUU|rcsb pdb:4ZCB|rcsb pdb:4ZGU|rcsb pdb:4ZH6|rcsb pdb:4ZH9|rcsb pdb:4ZJ0|rcsb pdb:4ZR2|rcsb pdb:5DG4|rcsb pdb:5DPQ|rcsb pdb:5F58|rcsb pdb:5F6B|rcsb pdb:5F7G|rcsb pdb:5FAZ|rcsb pdb:5FEN|rcsb pdb:5FFH|rcsb pdb:5U6G|rcsb pdb:6BTH|rcsb pdb:6BTI|rcsb pdb:6C7Z|rcsb pdb:6E50|rcsb pdb:6E51|rcsb pdb:6E5E|rcsb pdb:6E5Q|rcsb pdb:6E5R|rcsb pdb:6E5S|rcsb pdb:6E6L|rcsb pdb:6E7M|rcsb pdb:6MCU|rcsb pdb:6MCV|rcsb pdb:6MKV|rcsb pdb:6MLB|rcsb pdb:6ON5|rcsb pdb:6ON7|rcsb pdb:6ON8|rcsb pdb:6VID|rcsb pdb:6VIS|rcsb pdb:6VIT|rcsb pdb:6WNF|rcsb pdb:6WNJ|rcsb pdb:6WP0|rcsb pdb:6WP1|rcsb pdb:6WP2|rcsb pdb:7JVG|rcsb pdb:7JVY|rcsb pdb:7JWD|rcsb pdb:7JWR|rcsb pdb:7JX2|rcsb pdb:7JZ5|rcsb pdb:7K3I|rcsb pdb:7LHJ|rcsb pdb:7LHM|rcsb pdb:7LHN|rcsb pdb:7LHO|reactome:R-HSA-975634|rcsb pdb:4EEJ	refseq:NP_001027459.1|refseq:NP_068823.2|refseq:NP_071887.1|refseq:NP_954595.1|refseq:NP_954673.1|refseq:NP_001244322.1|refseq:NP_001244323.1|refseq:NP_001244325.1|ensembl:ENSG00000244687(gene)|ensembl:ENST00000371674(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006282"(regulation of DNA repair)|go:"GO:0006301"(postreplication repair)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0030154"(cell differentiation)|go:"GO:0031371"(ubiquitin conjugating enzyme complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035370"(UBC13-UEV1A complex)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070534"(protein K63-linked ubiquitination)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|rcsb pdb:2A4D|rcsb pdb:2C2V|rcsb pdb:2HLW|rcsb pdb:6D6I|reactome:R-HSA-168638|reactome:R-HSA-168927|reactome:R-HSA-202424|reactome:R-HSA-2871837|reactome:R-HSA-445989|reactome:R-HSA-450302|reactome:R-HSA-450321|reactome:R-HSA-5607764|reactome:R-HSA-9020702|reactome:R-HSA-937039|reactome:R-HSA-937041|reactome:R-HSA-9646399|reactome:R-HSA-975110|reactome:R-HSA-975144|reactome:R-HSA-983168|dip:DIP-41911N	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S2|caution:"UBE2N has been marked as the enzyme in this assay, although it is the UBE2N-UBE2V1 complex that has ubiquitinase (E3) activity. Neither UBE2N nor UBE2V1 have E2 or E3 activity on their own."|resulting-ptm:P50120 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:AbUO7A6PRFKpNQQK0AsOZx6IEUw9606	rogid:x95N7Dj2KIqu5gySX59xLmfthUg9606	intact-crc:1B2273DC784D13F9|rigid:/cU3+aHZ7W805ln0jUKyBGn52EI	false	-	his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P50120	uniprotkb:P22314	intact:EBI-9915923|uniprotkb:Q6ISQ9|uniprotkb:A8K7G3|uniprotkb:Q6ISS7|ensembl:ENSP00000232217	intact:EBI-709688|uniprotkb:Q96E13|uniprotkb:Q5JRR8|ensembl:ENSP00000338413|ensembl:ENSP00000366568	psi-mi:ret2_human(display_long)|uniprotkb:CRBP2(gene name synonym)|uniprotkb:Cellular retinol-binding protein II(gene name synonym)|uniprotkb:RBP2(gene name)|psi-mi:RBP2(display_short)	psi-mi:uba1_human(display_long)|uniprotkb:Ubiquitin-activating enzyme E1(gene name synonym)|uniprotkb:Protein A1S9(gene name synonym)|uniprotkb:UBA1(gene name)|psi-mi:UBA1(display_short)|uniprotkb:A1S9T(gene name synonym)|uniprotkb:UBE1(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9970325|imex:IM-22822-20	author-confidence:Z-score = 3.18	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_004155.2|ensembl:ENSG00000114113(gene)|ensembl:ENST00000232217(transcript)|go:"GO:0005501"(retinoid binding)|go:"GO:0005829"(cytosol)|go:"GO:0006776"(vitamin A metabolic process)|go:"GO:0008544"(epidermis development)|go:"GO:0016918"(retinal binding)|go:"GO:0019841"(retinol binding)|interpro:IPR000463(Cytosolic fatty-acid binding)|interpro:IPR000566(Lipocalin-related protein and Bos/Can/Equ allergen)|interpro:IPR012674(Calycin)|interpro:IPR031259|rcsb pdb:2RCQ|rcsb pdb:2RCT|rcsb pdb:4EDE|rcsb pdb:4EFG|rcsb pdb:4EXZ|rcsb pdb:4GKC|rcsb pdb:4QYN|rcsb pdb:4QYP|rcsb pdb:4QZT|rcsb pdb:4QZU|rcsb pdb:4RUU|rcsb pdb:4ZCB|rcsb pdb:4ZGU|rcsb pdb:4ZH6|rcsb pdb:4ZH9|rcsb pdb:4ZJ0|rcsb pdb:4ZR2|rcsb pdb:5DG4|rcsb pdb:5DPQ|rcsb pdb:5F58|rcsb pdb:5F6B|rcsb pdb:5F7G|rcsb pdb:5FAZ|rcsb pdb:5FEN|rcsb pdb:5FFH|rcsb pdb:5U6G|rcsb pdb:6BTH|rcsb pdb:6BTI|rcsb pdb:6C7Z|rcsb pdb:6E50|rcsb pdb:6E51|rcsb pdb:6E5E|rcsb pdb:6E5Q|rcsb pdb:6E5R|rcsb pdb:6E5S|rcsb pdb:6E6L|rcsb pdb:6E7M|rcsb pdb:6MCU|rcsb pdb:6MCV|rcsb pdb:6MKV|rcsb pdb:6MLB|rcsb pdb:6ON5|rcsb pdb:6ON7|rcsb pdb:6ON8|rcsb pdb:6VID|rcsb pdb:6VIS|rcsb pdb:6VIT|rcsb pdb:6WNF|rcsb pdb:6WNJ|rcsb pdb:6WP0|rcsb pdb:6WP1|rcsb pdb:6WP2|rcsb pdb:7JVG|rcsb pdb:7JVY|rcsb pdb:7JWD|rcsb pdb:7JWR|rcsb pdb:7JX2|rcsb pdb:7JZ5|rcsb pdb:7K3I|rcsb pdb:7LHJ|rcsb pdb:7LHM|rcsb pdb:7LHN|rcsb pdb:7LHO|reactome:R-HSA-975634|rcsb pdb:4EEJ	refseq:NP_003325.2|refseq:NP_695012.1|refseq:XP_016885269.1|refseq:XP_016885270.1|dip:DIP-33686N|ensembl:ENSG00000130985(gene)|ensembl:ENST00000335972(transcript)|ensembl:ENST00000377351(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0004839"(ubiquitin activating enzyme activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0032446"(protein modification by small protein conjugation)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000011(Ubiquitin-activating enzyme, E1)|interpro:IPR000594(UBA/THIF-type NAD/FAD binding fold)|interpro:IPR018074|interpro:IPR018075|interpro:IPR018965|interpro:IPR019572|interpro:IPR032418|interpro:IPR032420|interpro:IPR033127|interpro:IPR035985|interpro:IPR038252|interpro:IPR042063|interpro:IPR042302|interpro:IPR042449|mint:P22314|rcsb pdb:4P22|rcsb pdb:6DC6|reactome:R-HSA-8866652|reactome:R-HSA-983168	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S2|caution:"UBE2N has been marked as the enzyme in this assay, although it is the UBE2N-UBE2V1 complex that has ubiquitinase (E3) activity. Neither UBE2N nor UBE2V1 have E2 or E3 activity on their own."|resulting-ptm:P50120 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:AbUO7A6PRFKpNQQK0AsOZx6IEUw9606	rogid:q+vEeA0XLST0Zz173bmEt0dNbDE9606	intact-crc:1B2273DC784D13F9|rigid:/cU3+aHZ7W805ln0jUKyBGn52EI	false	-	his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P50120	uniprotkb:P61088	intact:EBI-9915923|uniprotkb:Q6ISQ9|uniprotkb:A8K7G3|uniprotkb:Q6ISS7|ensembl:ENSP00000232217	intact:EBI-1052908|uniprotkb:Q16781|uniprotkb:Q53Y81|ensembl:ENSP00000316176	psi-mi:ret2_human(display_long)|uniprotkb:CRBP2(gene name synonym)|uniprotkb:Cellular retinol-binding protein II(gene name synonym)|uniprotkb:RBP2(gene name)|psi-mi:RBP2(display_short)	psi-mi:ube2n_human(display_long)|uniprotkb:Ubiquitin-protein ligase N(gene name synonym)|uniprotkb:Ubiquitin carrier protein N(gene name synonym)|uniprotkb:Ubc13(gene name synonym)|uniprotkb:Bendless-like ubiquitin-conjugating enzyme(gene name synonym)|uniprotkb:UBE2N(gene name)|psi-mi:UBE2N(display_short)|uniprotkb:BLU(gene name synonym)|uniprotkb:UbcH13(gene name synonym)|uniprotkb:E2 ubiquitin-conjugating enzyme N(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9970325|imex:IM-22822-20	author-confidence:Z-score = 3.18	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_004155.2|ensembl:ENSG00000114113(gene)|ensembl:ENST00000232217(transcript)|go:"GO:0005501"(retinoid binding)|go:"GO:0005829"(cytosol)|go:"GO:0006776"(vitamin A metabolic process)|go:"GO:0008544"(epidermis development)|go:"GO:0016918"(retinal binding)|go:"GO:0019841"(retinol binding)|interpro:IPR000463(Cytosolic fatty-acid binding)|interpro:IPR000566(Lipocalin-related protein and Bos/Can/Equ allergen)|interpro:IPR012674(Calycin)|interpro:IPR031259|rcsb pdb:2RCQ|rcsb pdb:2RCT|rcsb pdb:4EDE|rcsb pdb:4EFG|rcsb pdb:4EXZ|rcsb pdb:4GKC|rcsb pdb:4QYN|rcsb pdb:4QYP|rcsb pdb:4QZT|rcsb pdb:4QZU|rcsb pdb:4RUU|rcsb pdb:4ZCB|rcsb pdb:4ZGU|rcsb pdb:4ZH6|rcsb pdb:4ZH9|rcsb pdb:4ZJ0|rcsb pdb:4ZR2|rcsb pdb:5DG4|rcsb pdb:5DPQ|rcsb pdb:5F58|rcsb pdb:5F6B|rcsb pdb:5F7G|rcsb pdb:5FAZ|rcsb pdb:5FEN|rcsb pdb:5FFH|rcsb pdb:5U6G|rcsb pdb:6BTH|rcsb pdb:6BTI|rcsb pdb:6C7Z|rcsb pdb:6E50|rcsb pdb:6E51|rcsb pdb:6E5E|rcsb pdb:6E5Q|rcsb pdb:6E5R|rcsb pdb:6E5S|rcsb pdb:6E6L|rcsb pdb:6E7M|rcsb pdb:6MCU|rcsb pdb:6MCV|rcsb pdb:6MKV|rcsb pdb:6MLB|rcsb pdb:6ON5|rcsb pdb:6ON7|rcsb pdb:6ON8|rcsb pdb:6VID|rcsb pdb:6VIS|rcsb pdb:6VIT|rcsb pdb:6WNF|rcsb pdb:6WNJ|rcsb pdb:6WP0|rcsb pdb:6WP1|rcsb pdb:6WP2|rcsb pdb:7JVG|rcsb pdb:7JVY|rcsb pdb:7JWD|rcsb pdb:7JWR|rcsb pdb:7JX2|rcsb pdb:7JZ5|rcsb pdb:7K3I|rcsb pdb:7LHJ|rcsb pdb:7LHM|rcsb pdb:7LHN|rcsb pdb:7LHO|reactome:R-HSA-975634|rcsb pdb:4EEJ	refseq:NP_003339.1|dip:DIP-29829N|ensembl:ENSG00000177889(gene)|ensembl:ENST00000318066(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000729"(DNA double-strand break processing)|go:"GO:0001650"(fibrillar center)|go:"GO:0003723"(RNA binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006282"(regulation of DNA repair)|go:"GO:0006301"(postreplication repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016574"(histone ubiquitination)|go:"GO:0031058"(positive regulation of histone modification)|go:"GO:0031372"(UBC13-MMS2 complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033182"(regulation of histone ubiquitination)|go:"GO:0035370"(UBC13-UEV1A complex)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0061631"(ubiquitin conjugating enzyme activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070534"(protein K63-linked ubiquitination)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|interpro:IPR023313|rcsb pdb:1J7D|rcsb pdb:2C2V|rcsb pdb:3HCT|rcsb pdb:3HCU|rcsb pdb:3VON|rcsb pdb:3W31|rcsb pdb:4DHI|rcsb pdb:4DHJ|rcsb pdb:4DHZ|rcsb pdb:4IP3|rcsb pdb:4NR3|rcsb pdb:4NRG|rcsb pdb:4NRI|rcsb pdb:4ONL|rcsb pdb:4ONM|rcsb pdb:4ONN|rcsb pdb:4ORH|rcsb pdb:4TKP|rcsb pdb:4WHV|rcsb pdb:5AIT|rcsb pdb:5AIU|rcsb pdb:5EYA|rcsb pdb:5H7S|rcsb pdb:5VNZ|rcsb pdb:5VO0|rcsb pdb:5YWR|rcsb pdb:6D6I|rcsb pdb:6JKY|rcsb pdb:6KFP|rcsb pdb:6KG6|rcsb pdb:6KL4|rcsb pdb:6LP2|rcsb pdb:6P5B|rcsb pdb:6S53|reactome:R-HSA-168927|reactome:R-HSA-202424|reactome:R-HSA-2871837|reactome:R-HSA-445989|reactome:R-HSA-450302|reactome:R-HSA-450321|reactome:R-HSA-5607764|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-5696395|reactome:R-HSA-69473|reactome:R-HSA-8866654|reactome:R-HSA-9020702|reactome:R-HSA-937039|reactome:R-HSA-937041|reactome:R-HSA-9646399|reactome:R-HSA-975110|reactome:R-HSA-975144|reactome:R-HSA-983168|rcsb pdb:6ULH|rcsb pdb:6UMP|rcsb pdb:6UMS|rcsb pdb:7BBD|rcsb pdb:7BBF|rcsb pdb:7BXG|reactome:R-HSA-1169408|reactome:R-HSA-168638	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S2|caution:"UBE2N has been marked as the enzyme in this assay, although it is the UBE2N-UBE2V1 complex that has ubiquitinase (E3) activity. Neither UBE2N nor UBE2V1 have E2 or E3 activity on their own."|resulting-ptm:P50120 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:AbUO7A6PRFKpNQQK0AsOZx6IEUw9606	rogid:dqdszHlq5FLPHC6UWX6uvkC6Yz89606	intact-crc:1B2273DC784D13F9|rigid:/cU3+aHZ7W805ln0jUKyBGn52EI	false	-	his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P36406	uniprotkb:Q13404	intact:EBI-740098|uniprotkb:Q9BZY4|uniprotkb:Q9BZY5|ensembl:ENSP00000231524	intact:EBI-1050671|uniprotkb:Q13403|uniprotkb:Q13532|uniprotkb:Q96H34|uniprotkb:Q9GZT0|uniprotkb:Q9GZW1|uniprotkb:Q9H4J3|uniprotkb:Q9H4J4|uniprotkb:Q9UKL1|uniprotkb:Q9UM48|uniprotkb:Q9UM49|uniprotkb:Q9UM50|uniprotkb:Q5TGE3|uniprotkb:E1P629|uniprotkb:Q5TGE0|ensembl:ENSP00000360739	psi-mi:tri23_human(display_long)|uniprotkb:TRIM23(gene name)|psi-mi:TRIM23(display_short)|uniprotkb:ARD1(gene name synonym)|uniprotkb:ARFD1(gene name synonym)|uniprotkb:RNF46(gene name synonym)|uniprotkb:ADP-ribosylation factor domain-containing protein 1(gene name synonym)|uniprotkb:Tripartite motif-containing protein 23(gene name synonym)|uniprotkb:RING finger protein 46(gene name synonym)|uniprotkb:GTP-binding protein ARD-1(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase TRIM23(gene name synonym)	psi-mi:ub2v1_human(display_long)|uniprotkb:CROC-1(gene name synonym)|uniprotkb:TRAF6-regulated IKK activator 1 beta Uev1A(gene name synonym)|uniprotkb:P/OKcl.19(orf name)|uniprotkb:UBE2V1(gene name)|psi-mi:UBE2V1(display_short)|uniprotkb:CROC1(gene name synonym)|uniprotkb:UBE2V(gene name synonym)|uniprotkb:UEV1(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9970304|imex:IM-22822-19	author-confidence:Z-score = 3.39	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001647.1|refseq:NP_150230.1|refseq:NP_150231.1|refseq:XP_016864933.1|ensembl:ENSG00000113595(gene)|ensembl:ENST00000231524(transcript)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0000139"(Golgi membrane)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0008047"(enzyme activator activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019003"(GDP binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0045087"(innate immune response)|interpro:IPR000315(Zinc finger, B-box)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR003649(B-box, C-terminal)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR006689(ARF/SAR superfamily)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR017907|interpro:IPR027417|mint:P36406|rcsb pdb:5VZV|rcsb pdb:5VZW	refseq:NP_001027459.1|refseq:NP_068823.2|refseq:NP_071887.1|refseq:NP_954595.1|refseq:NP_954673.1|refseq:NP_001244322.1|refseq:NP_001244323.1|refseq:NP_001244325.1|ensembl:ENSG00000244687(gene)|ensembl:ENST00000371674(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006282"(regulation of DNA repair)|go:"GO:0006301"(postreplication repair)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0030154"(cell differentiation)|go:"GO:0031371"(ubiquitin conjugating enzyme complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035370"(UBC13-UEV1A complex)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070534"(protein K63-linked ubiquitination)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|rcsb pdb:2A4D|rcsb pdb:2C2V|rcsb pdb:2HLW|rcsb pdb:6D6I|reactome:R-HSA-168638|reactome:R-HSA-168927|reactome:R-HSA-202424|reactome:R-HSA-2871837|reactome:R-HSA-445989|reactome:R-HSA-450302|reactome:R-HSA-450321|reactome:R-HSA-5607764|reactome:R-HSA-9020702|reactome:R-HSA-937039|reactome:R-HSA-937041|reactome:R-HSA-9646399|reactome:R-HSA-975110|reactome:R-HSA-975144|reactome:R-HSA-983168|dip:DIP-41911N	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S2|caution:"UBE2N has been marked as the enzyme in this assay, although it is the UBE2N-UBE2V1 complex that has ubiquitinase (E3) activity. Neither UBE2N nor UBE2V1 have E2 or E3 activity on their own."|resulting-ptm:P36406 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:skGAO7nm9YvqJGWF6fzjtn5CWuc9606	rogid:x95N7Dj2KIqu5gySX59xLmfthUg9606	intact-crc:78FDDE5C99F63793|rigid:RqbYeA8bUXXhEi4Gcih8afBRNJM	false	-	his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P36406	uniprotkb:P22314	intact:EBI-740098|uniprotkb:Q9BZY4|uniprotkb:Q9BZY5|ensembl:ENSP00000231524	intact:EBI-709688|uniprotkb:Q96E13|uniprotkb:Q5JRR8|ensembl:ENSP00000338413|ensembl:ENSP00000366568	psi-mi:tri23_human(display_long)|uniprotkb:TRIM23(gene name)|psi-mi:TRIM23(display_short)|uniprotkb:ARD1(gene name synonym)|uniprotkb:ARFD1(gene name synonym)|uniprotkb:RNF46(gene name synonym)|uniprotkb:ADP-ribosylation factor domain-containing protein 1(gene name synonym)|uniprotkb:Tripartite motif-containing protein 23(gene name synonym)|uniprotkb:RING finger protein 46(gene name synonym)|uniprotkb:GTP-binding protein ARD-1(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase TRIM23(gene name synonym)	psi-mi:uba1_human(display_long)|uniprotkb:Ubiquitin-activating enzyme E1(gene name synonym)|uniprotkb:Protein A1S9(gene name synonym)|uniprotkb:UBA1(gene name)|psi-mi:UBA1(display_short)|uniprotkb:A1S9T(gene name synonym)|uniprotkb:UBE1(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9970304|imex:IM-22822-19	author-confidence:Z-score = 3.39	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001647.1|refseq:NP_150230.1|refseq:NP_150231.1|refseq:XP_016864933.1|ensembl:ENSG00000113595(gene)|ensembl:ENST00000231524(transcript)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0000139"(Golgi membrane)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0008047"(enzyme activator activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019003"(GDP binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0045087"(innate immune response)|interpro:IPR000315(Zinc finger, B-box)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR003649(B-box, C-terminal)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR006689(ARF/SAR superfamily)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR017907|interpro:IPR027417|mint:P36406|rcsb pdb:5VZV|rcsb pdb:5VZW	refseq:NP_003325.2|refseq:NP_695012.1|refseq:XP_016885269.1|refseq:XP_016885270.1|dip:DIP-33686N|ensembl:ENSG00000130985(gene)|ensembl:ENST00000335972(transcript)|ensembl:ENST00000377351(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0004839"(ubiquitin activating enzyme activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0032446"(protein modification by small protein conjugation)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000011(Ubiquitin-activating enzyme, E1)|interpro:IPR000594(UBA/THIF-type NAD/FAD binding fold)|interpro:IPR018074|interpro:IPR018075|interpro:IPR018965|interpro:IPR019572|interpro:IPR032418|interpro:IPR032420|interpro:IPR033127|interpro:IPR035985|interpro:IPR038252|interpro:IPR042063|interpro:IPR042302|interpro:IPR042449|mint:P22314|rcsb pdb:4P22|rcsb pdb:6DC6|reactome:R-HSA-8866652|reactome:R-HSA-983168	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S2|caution:"UBE2N has been marked as the enzyme in this assay, although it is the UBE2N-UBE2V1 complex that has ubiquitinase (E3) activity. Neither UBE2N nor UBE2V1 have E2 or E3 activity on their own."|resulting-ptm:P36406 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:skGAO7nm9YvqJGWF6fzjtn5CWuc9606	rogid:q+vEeA0XLST0Zz173bmEt0dNbDE9606	intact-crc:78FDDE5C99F63793|rigid:RqbYeA8bUXXhEi4Gcih8afBRNJM	false	-	his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P36406	uniprotkb:P61088	intact:EBI-740098|uniprotkb:Q9BZY4|uniprotkb:Q9BZY5|ensembl:ENSP00000231524	intact:EBI-1052908|uniprotkb:Q16781|uniprotkb:Q53Y81|ensembl:ENSP00000316176	psi-mi:tri23_human(display_long)|uniprotkb:TRIM23(gene name)|psi-mi:TRIM23(display_short)|uniprotkb:ARD1(gene name synonym)|uniprotkb:ARFD1(gene name synonym)|uniprotkb:RNF46(gene name synonym)|uniprotkb:ADP-ribosylation factor domain-containing protein 1(gene name synonym)|uniprotkb:Tripartite motif-containing protein 23(gene name synonym)|uniprotkb:RING finger protein 46(gene name synonym)|uniprotkb:GTP-binding protein ARD-1(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase TRIM23(gene name synonym)	psi-mi:ube2n_human(display_long)|uniprotkb:Ubiquitin-protein ligase N(gene name synonym)|uniprotkb:Ubiquitin carrier protein N(gene name synonym)|uniprotkb:Ubc13(gene name synonym)|uniprotkb:Bendless-like ubiquitin-conjugating enzyme(gene name synonym)|uniprotkb:UBE2N(gene name)|psi-mi:UBE2N(display_short)|uniprotkb:BLU(gene name synonym)|uniprotkb:UbcH13(gene name synonym)|uniprotkb:E2 ubiquitin-conjugating enzyme N(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9970304|imex:IM-22822-19	author-confidence:Z-score = 3.39	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001647.1|refseq:NP_150230.1|refseq:NP_150231.1|refseq:XP_016864933.1|ensembl:ENSG00000113595(gene)|ensembl:ENST00000231524(transcript)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0000139"(Golgi membrane)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0008047"(enzyme activator activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019003"(GDP binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0045087"(innate immune response)|interpro:IPR000315(Zinc finger, B-box)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR003649(B-box, C-terminal)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR006689(ARF/SAR superfamily)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR017907|interpro:IPR027417|mint:P36406|rcsb pdb:5VZV|rcsb pdb:5VZW	refseq:NP_003339.1|dip:DIP-29829N|ensembl:ENSG00000177889(gene)|ensembl:ENST00000318066(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000729"(DNA double-strand break processing)|go:"GO:0001650"(fibrillar center)|go:"GO:0003723"(RNA binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006282"(regulation of DNA repair)|go:"GO:0006301"(postreplication repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016574"(histone ubiquitination)|go:"GO:0031058"(positive regulation of histone modification)|go:"GO:0031372"(UBC13-MMS2 complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033182"(regulation of histone ubiquitination)|go:"GO:0035370"(UBC13-UEV1A complex)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0061631"(ubiquitin conjugating enzyme activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070534"(protein K63-linked ubiquitination)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|interpro:IPR023313|rcsb pdb:1J7D|rcsb pdb:2C2V|rcsb pdb:3HCT|rcsb pdb:3HCU|rcsb pdb:3VON|rcsb pdb:3W31|rcsb pdb:4DHI|rcsb pdb:4DHJ|rcsb pdb:4DHZ|rcsb pdb:4IP3|rcsb pdb:4NR3|rcsb pdb:4NRG|rcsb pdb:4NRI|rcsb pdb:4ONL|rcsb pdb:4ONM|rcsb pdb:4ONN|rcsb pdb:4ORH|rcsb pdb:4TKP|rcsb pdb:4WHV|rcsb pdb:5AIT|rcsb pdb:5AIU|rcsb pdb:5EYA|rcsb pdb:5H7S|rcsb pdb:5VNZ|rcsb pdb:5VO0|rcsb pdb:5YWR|rcsb pdb:6D6I|rcsb pdb:6JKY|rcsb pdb:6KFP|rcsb pdb:6KG6|rcsb pdb:6KL4|rcsb pdb:6LP2|rcsb pdb:6P5B|rcsb pdb:6S53|reactome:R-HSA-168927|reactome:R-HSA-202424|reactome:R-HSA-2871837|reactome:R-HSA-445989|reactome:R-HSA-450302|reactome:R-HSA-450321|reactome:R-HSA-5607764|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-5696395|reactome:R-HSA-69473|reactome:R-HSA-8866654|reactome:R-HSA-9020702|reactome:R-HSA-937039|reactome:R-HSA-937041|reactome:R-HSA-9646399|reactome:R-HSA-975110|reactome:R-HSA-975144|reactome:R-HSA-983168|rcsb pdb:6ULH|rcsb pdb:6UMP|rcsb pdb:6UMS|rcsb pdb:7BBD|rcsb pdb:7BBF|rcsb pdb:7BXG|reactome:R-HSA-1169408|reactome:R-HSA-168638	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S2|caution:"UBE2N has been marked as the enzyme in this assay, although it is the UBE2N-UBE2V1 complex that has ubiquitinase (E3) activity. Neither UBE2N nor UBE2V1 have E2 or E3 activity on their own."|resulting-ptm:P36406 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:skGAO7nm9YvqJGWF6fzjtn5CWuc9606	rogid:dqdszHlq5FLPHC6UWX6uvkC6Yz89606	intact-crc:78FDDE5C99F63793|rigid:RqbYeA8bUXXhEi4Gcih8afBRNJM	false	-	his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P51965	uniprotkb:Q13404	intact:EBI-348546|uniprotkb:B2RBX4|ensembl:ENSP00000303709|uniprotkb:C9J8K2|uniprotkb:K4DI90	intact:EBI-1050671|uniprotkb:Q13403|uniprotkb:Q13532|uniprotkb:Q96H34|uniprotkb:Q9GZT0|uniprotkb:Q9GZW1|uniprotkb:Q9H4J3|uniprotkb:Q9H4J4|uniprotkb:Q9UKL1|uniprotkb:Q9UM48|uniprotkb:Q9UM49|uniprotkb:Q9UM50|uniprotkb:Q5TGE3|uniprotkb:E1P629|uniprotkb:Q5TGE0|ensembl:ENSP00000360739	psi-mi:ub2e1_human(display_long)|uniprotkb:UBE2E1(gene name)|psi-mi:UBE2E1(display_short)|uniprotkb:UBCH6(gene name synonym)|uniprotkb:Ubiquitin-protein ligase E1(gene name synonym)|uniprotkb:Ubiquitin carrier protein E1(gene name synonym)|uniprotkb:UbcH6(gene name synonym)|uniprotkb:"(E3-independent) E2 ubiquitin-conjugating enzyme E1"(gene name synonym)|uniprotkb:E2 ubiquitin-conjugating enzyme E1(gene name synonym)	psi-mi:ub2v1_human(display_long)|uniprotkb:CROC-1(gene name synonym)|uniprotkb:TRAF6-regulated IKK activator 1 beta Uev1A(gene name synonym)|uniprotkb:P/OKcl.19(orf name)|uniprotkb:UBE2V1(gene name)|psi-mi:UBE2V1(display_short)|uniprotkb:CROC1(gene name synonym)|uniprotkb:UBE2V(gene name synonym)|uniprotkb:UEV1(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9970346|imex:IM-22822-21	author-confidence:Z-score = 4.59	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_003332.1|refseq:NP_872607.1|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|go:"GO:0070936"(protein K48-linked ubiquitination)|interpro:IPR023313|rcsb pdb:1XR9|rcsb pdb:3BZH|rcsb pdb:4JJQ|rcsb pdb:5LBN|rcsb pdb:6FGA|reactome:R-HSA-1169408|reactome:R-HSA-141430|reactome:R-HSA-174048|reactome:R-HSA-174084|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-176407|reactome:R-HSA-176408|reactome:R-HSA-176409|reactome:R-HSA-176412|reactome:R-HSA-179409|reactome:R-HSA-2467813|reactome:R-HSA-2559582|reactome:R-HSA-69017|reactome:R-HSA-8853884|reactome:R-HSA-8866652|reactome:R-HSA-8866654|reactome:R-HSA-9687136|reactome:R-HSA-983168|ensembl:ENST00000306627(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0010390"(histone monoubiquitination)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0032020"(ISG15-protein conjugation)|go:"GO:0033523"(histone H2B ubiquitination)|go:"GO:0042296"(ISG15 transferase activity)|go:"GO:0061631"(ubiquitin conjugating enzyme activity)|ensembl:ENSG00000170142(gene)|refseq:NP_001189405.1	refseq:NP_001027459.1|refseq:NP_068823.2|refseq:NP_071887.1|refseq:NP_954595.1|refseq:NP_954673.1|refseq:NP_001244322.1|refseq:NP_001244323.1|refseq:NP_001244325.1|ensembl:ENSG00000244687(gene)|ensembl:ENST00000371674(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006282"(regulation of DNA repair)|go:"GO:0006301"(postreplication repair)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0030154"(cell differentiation)|go:"GO:0031371"(ubiquitin conjugating enzyme complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035370"(UBC13-UEV1A complex)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070534"(protein K63-linked ubiquitination)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|rcsb pdb:2A4D|rcsb pdb:2C2V|rcsb pdb:2HLW|rcsb pdb:6D6I|reactome:R-HSA-168638|reactome:R-HSA-168927|reactome:R-HSA-202424|reactome:R-HSA-2871837|reactome:R-HSA-445989|reactome:R-HSA-450302|reactome:R-HSA-450321|reactome:R-HSA-5607764|reactome:R-HSA-9020702|reactome:R-HSA-937039|reactome:R-HSA-937041|reactome:R-HSA-9646399|reactome:R-HSA-975110|reactome:R-HSA-975144|reactome:R-HSA-983168|dip:DIP-41911N	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S2|caution:"UBE2N has been marked as the enzyme in this assay, although it is the UBE2N-UBE2V1 complex that has ubiquitinase (E3) activity. Neither UBE2N nor UBE2V1 have E2 or E3 activity on their own."|resulting-ptm:P51965 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:pPIqYniSQn5Jh7u5x0Lm2NXppQU9606	rogid:x95N7Dj2KIqu5gySX59xLmfthUg9606	intact-crc:89988BCBD01F17D2|rigid:ESs4wDtzm+ejqy8ULejOQkZr0z8	false	-	his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P51965	uniprotkb:P22314	intact:EBI-348546|uniprotkb:B2RBX4|ensembl:ENSP00000303709|uniprotkb:C9J8K2|uniprotkb:K4DI90	intact:EBI-709688|uniprotkb:Q96E13|uniprotkb:Q5JRR8|ensembl:ENSP00000338413|ensembl:ENSP00000366568	psi-mi:ub2e1_human(display_long)|uniprotkb:UBE2E1(gene name)|psi-mi:UBE2E1(display_short)|uniprotkb:UBCH6(gene name synonym)|uniprotkb:Ubiquitin-protein ligase E1(gene name synonym)|uniprotkb:Ubiquitin carrier protein E1(gene name synonym)|uniprotkb:UbcH6(gene name synonym)|uniprotkb:"(E3-independent) E2 ubiquitin-conjugating enzyme E1"(gene name synonym)|uniprotkb:E2 ubiquitin-conjugating enzyme E1(gene name synonym)	psi-mi:uba1_human(display_long)|uniprotkb:Ubiquitin-activating enzyme E1(gene name synonym)|uniprotkb:Protein A1S9(gene name synonym)|uniprotkb:UBA1(gene name)|psi-mi:UBA1(display_short)|uniprotkb:A1S9T(gene name synonym)|uniprotkb:UBE1(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9970346|imex:IM-22822-21	author-confidence:Z-score = 4.59	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_003332.1|refseq:NP_872607.1|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|go:"GO:0070936"(protein K48-linked ubiquitination)|interpro:IPR023313|rcsb pdb:1XR9|rcsb pdb:3BZH|rcsb pdb:4JJQ|rcsb pdb:5LBN|rcsb pdb:6FGA|reactome:R-HSA-1169408|reactome:R-HSA-141430|reactome:R-HSA-174048|reactome:R-HSA-174084|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-176407|reactome:R-HSA-176408|reactome:R-HSA-176409|reactome:R-HSA-176412|reactome:R-HSA-179409|reactome:R-HSA-2467813|reactome:R-HSA-2559582|reactome:R-HSA-69017|reactome:R-HSA-8853884|reactome:R-HSA-8866652|reactome:R-HSA-8866654|reactome:R-HSA-9687136|reactome:R-HSA-983168|ensembl:ENST00000306627(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0010390"(histone monoubiquitination)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0032020"(ISG15-protein conjugation)|go:"GO:0033523"(histone H2B ubiquitination)|go:"GO:0042296"(ISG15 transferase activity)|go:"GO:0061631"(ubiquitin conjugating enzyme activity)|ensembl:ENSG00000170142(gene)|refseq:NP_001189405.1	refseq:NP_003325.2|refseq:NP_695012.1|refseq:XP_016885269.1|refseq:XP_016885270.1|dip:DIP-33686N|ensembl:ENSG00000130985(gene)|ensembl:ENST00000335972(transcript)|ensembl:ENST00000377351(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0004839"(ubiquitin activating enzyme activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0032446"(protein modification by small protein conjugation)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000011(Ubiquitin-activating enzyme, E1)|interpro:IPR000594(UBA/THIF-type NAD/FAD binding fold)|interpro:IPR018074|interpro:IPR018075|interpro:IPR018965|interpro:IPR019572|interpro:IPR032418|interpro:IPR032420|interpro:IPR033127|interpro:IPR035985|interpro:IPR038252|interpro:IPR042063|interpro:IPR042302|interpro:IPR042449|mint:P22314|rcsb pdb:4P22|rcsb pdb:6DC6|reactome:R-HSA-8866652|reactome:R-HSA-983168	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S2|caution:"UBE2N has been marked as the enzyme in this assay, although it is the UBE2N-UBE2V1 complex that has ubiquitinase (E3) activity. Neither UBE2N nor UBE2V1 have E2 or E3 activity on their own."|resulting-ptm:P51965 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:pPIqYniSQn5Jh7u5x0Lm2NXppQU9606	rogid:q+vEeA0XLST0Zz173bmEt0dNbDE9606	intact-crc:89988BCBD01F17D2|rigid:ESs4wDtzm+ejqy8ULejOQkZr0z8	false	-	his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P51965	uniprotkb:P61088	intact:EBI-348546|uniprotkb:B2RBX4|ensembl:ENSP00000303709|uniprotkb:C9J8K2|uniprotkb:K4DI90	intact:EBI-1052908|uniprotkb:Q16781|uniprotkb:Q53Y81|ensembl:ENSP00000316176	psi-mi:ub2e1_human(display_long)|uniprotkb:UBE2E1(gene name)|psi-mi:UBE2E1(display_short)|uniprotkb:UBCH6(gene name synonym)|uniprotkb:Ubiquitin-protein ligase E1(gene name synonym)|uniprotkb:Ubiquitin carrier protein E1(gene name synonym)|uniprotkb:UbcH6(gene name synonym)|uniprotkb:"(E3-independent) E2 ubiquitin-conjugating enzyme E1"(gene name synonym)|uniprotkb:E2 ubiquitin-conjugating enzyme E1(gene name synonym)	psi-mi:ube2n_human(display_long)|uniprotkb:Ubiquitin-protein ligase N(gene name synonym)|uniprotkb:Ubiquitin carrier protein N(gene name synonym)|uniprotkb:Ubc13(gene name synonym)|uniprotkb:Bendless-like ubiquitin-conjugating enzyme(gene name synonym)|uniprotkb:UBE2N(gene name)|psi-mi:UBE2N(display_short)|uniprotkb:BLU(gene name synonym)|uniprotkb:UbcH13(gene name synonym)|uniprotkb:E2 ubiquitin-conjugating enzyme N(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9970346|imex:IM-22822-21	author-confidence:Z-score = 4.59	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_003332.1|refseq:NP_872607.1|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|go:"GO:0070936"(protein K48-linked ubiquitination)|interpro:IPR023313|rcsb pdb:1XR9|rcsb pdb:3BZH|rcsb pdb:4JJQ|rcsb pdb:5LBN|rcsb pdb:6FGA|reactome:R-HSA-1169408|reactome:R-HSA-141430|reactome:R-HSA-174048|reactome:R-HSA-174084|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-176407|reactome:R-HSA-176408|reactome:R-HSA-176409|reactome:R-HSA-176412|reactome:R-HSA-179409|reactome:R-HSA-2467813|reactome:R-HSA-2559582|reactome:R-HSA-69017|reactome:R-HSA-8853884|reactome:R-HSA-8866652|reactome:R-HSA-8866654|reactome:R-HSA-9687136|reactome:R-HSA-983168|ensembl:ENST00000306627(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0010390"(histone monoubiquitination)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0032020"(ISG15-protein conjugation)|go:"GO:0033523"(histone H2B ubiquitination)|go:"GO:0042296"(ISG15 transferase activity)|go:"GO:0061631"(ubiquitin conjugating enzyme activity)|ensembl:ENSG00000170142(gene)|refseq:NP_001189405.1	refseq:NP_003339.1|dip:DIP-29829N|ensembl:ENSG00000177889(gene)|ensembl:ENST00000318066(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000729"(DNA double-strand break processing)|go:"GO:0001650"(fibrillar center)|go:"GO:0003723"(RNA binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006282"(regulation of DNA repair)|go:"GO:0006301"(postreplication repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016574"(histone ubiquitination)|go:"GO:0031058"(positive regulation of histone modification)|go:"GO:0031372"(UBC13-MMS2 complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033182"(regulation of histone ubiquitination)|go:"GO:0035370"(UBC13-UEV1A complex)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0061631"(ubiquitin conjugating enzyme activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070534"(protein K63-linked ubiquitination)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|interpro:IPR023313|rcsb pdb:1J7D|rcsb pdb:2C2V|rcsb pdb:3HCT|rcsb pdb:3HCU|rcsb pdb:3VON|rcsb pdb:3W31|rcsb pdb:4DHI|rcsb pdb:4DHJ|rcsb pdb:4DHZ|rcsb pdb:4IP3|rcsb pdb:4NR3|rcsb pdb:4NRG|rcsb pdb:4NRI|rcsb pdb:4ONL|rcsb pdb:4ONM|rcsb pdb:4ONN|rcsb pdb:4ORH|rcsb pdb:4TKP|rcsb pdb:4WHV|rcsb pdb:5AIT|rcsb pdb:5AIU|rcsb pdb:5EYA|rcsb pdb:5H7S|rcsb pdb:5VNZ|rcsb pdb:5VO0|rcsb pdb:5YWR|rcsb pdb:6D6I|rcsb pdb:6JKY|rcsb pdb:6KFP|rcsb pdb:6KG6|rcsb pdb:6KL4|rcsb pdb:6LP2|rcsb pdb:6P5B|rcsb pdb:6S53|reactome:R-HSA-168927|reactome:R-HSA-202424|reactome:R-HSA-2871837|reactome:R-HSA-445989|reactome:R-HSA-450302|reactome:R-HSA-450321|reactome:R-HSA-5607764|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-5696395|reactome:R-HSA-69473|reactome:R-HSA-8866654|reactome:R-HSA-9020702|reactome:R-HSA-937039|reactome:R-HSA-937041|reactome:R-HSA-9646399|reactome:R-HSA-975110|reactome:R-HSA-975144|reactome:R-HSA-983168|rcsb pdb:6ULH|rcsb pdb:6UMP|rcsb pdb:6UMS|rcsb pdb:7BBD|rcsb pdb:7BBF|rcsb pdb:7BXG|reactome:R-HSA-1169408|reactome:R-HSA-168638	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S2|caution:"UBE2N has been marked as the enzyme in this assay, although it is the UBE2N-UBE2V1 complex that has ubiquitinase (E3) activity. Neither UBE2N nor UBE2V1 have E2 or E3 activity on their own."|resulting-ptm:P51965 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:pPIqYniSQn5Jh7u5x0Lm2NXppQU9606	rogid:dqdszHlq5FLPHC6UWX6uvkC6Yz89606	intact-crc:89988BCBD01F17D2|rigid:ESs4wDtzm+ejqy8ULejOQkZr0z8	false	-	his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P61077	uniprotkb:Q13404	intact:EBI-348268|ensembl:ENSP00000318494|ensembl:ENSP00000337208|ensembl:ENSP00000378283|ensembl:ENSP00000396901|ensembl:ENSP00000344069|ensembl:ENSP00000378280|ensembl:ENSP00000378282|uniprotkb:A6NM99|intact:EBI-2809412|uniprotkb:P47986|uniprotkb:Q6IB88|uniprotkb:Q6NXS4|uniprotkb:Q8N924|uniprotkb:A6NJ93|uniprotkb:A6NJB1	intact:EBI-1050671|uniprotkb:Q13403|uniprotkb:Q13532|uniprotkb:Q96H34|uniprotkb:Q9GZT0|uniprotkb:Q9GZW1|uniprotkb:Q9H4J3|uniprotkb:Q9H4J4|uniprotkb:Q9UKL1|uniprotkb:Q9UM48|uniprotkb:Q9UM49|uniprotkb:Q9UM50|uniprotkb:Q5TGE3|uniprotkb:E1P629|uniprotkb:Q5TGE0|ensembl:ENSP00000360739	psi-mi:ub2d3_human(display_long)|uniprotkb:UBC5C(gene name synonym)|uniprotkb:Ubiquitin-protein ligase D3(gene name synonym)|uniprotkb:Ubiquitin carrier protein D3(gene name synonym)|uniprotkb:Ubiquitin-conjugating enzyme E2-17 kDa 3(gene name synonym)|uniprotkb:"Ubiquitin-conjugating enzyme E2(17)KB 3"(gene name synonym)|uniprotkb:UBE2D3(gene name)|psi-mi:UBE2D3(display_short)|uniprotkb:UBCH5C(gene name synonym)|uniprotkb:"(E3-independent) E2 ubiquitin-conjugating enzyme D3"(gene name synonym)|uniprotkb:E2 ubiquitin-conjugating enzyme D3(gene name synonym)	psi-mi:ub2v1_human(display_long)|uniprotkb:CROC-1(gene name synonym)|uniprotkb:TRAF6-regulated IKK activator 1 beta Uev1A(gene name synonym)|uniprotkb:P/OKcl.19(orf name)|uniprotkb:UBE2V1(gene name)|psi-mi:UBE2V1(display_short)|uniprotkb:CROC1(gene name synonym)|uniprotkb:UBE2V(gene name synonym)|uniprotkb:UEV1(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9970388|imex:IM-22822-23	author-confidence:Z-score = 5.72	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000109332(gene)|ensembl:ENST00000321805(transcript)|ensembl:ENST00000338145(transcript)|ensembl:ENST00000349311(transcript)|ensembl:ENST00000394801(transcript)|ensembl:ENST00000394803(transcript)|ensembl:ENST00000394804(transcript)|ensembl:ENST00000453744(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006281"(DNA repair)|go:"GO:0006513"(protein monoubiquitination)|go:"GO:0006915"(apoptotic process)|go:"GO:0010008"(endosome membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0006464"(cellular protein modification process)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0061631"(ubiquitin conjugating enzyme activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070936"(protein K48-linked ubiquitination)|go:"GO:0070979"(protein K11-linked ubiquitination)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0071288"(cellular response to mercury ion)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|interpro:IPR023313|rcsb pdb:2FUH|rcsb pdb:3L1Z|rcsb pdb:3RPG|rcsb pdb:3UGB|rcsb pdb:4BVU|rcsb pdb:4R8P|rcsb pdb:4S3O|rcsb pdb:5EGG|rcsb pdb:5IFR|rcsb pdb:6CP0|rcsb pdb:6T7F|rcsb pdb:7JZV|reactome:R-HSA-1234176|reactome:R-HSA-168927|reactome:R-HSA-201451|reactome:R-HSA-2173795|reactome:R-HSA-8866654|reactome:R-HSA-8951664|reactome:R-HSA-9033241|reactome:R-HSA-936440|reactome:R-HSA-937041|reactome:R-HSA-9705462|reactome:R-HSA-983168|rcsb pdb:1X23|refseq:NP_003331.1|refseq:NP_871615.1|refseq:NP_871616.1|refseq:NP_871617.1|refseq:NP_871618.1|refseq:NP_871619.1|refseq:NP_871620.1|refseq:NP_871621.1|refseq:NP_871622.1|dip:DIP-29062N	refseq:NP_001027459.1|refseq:NP_068823.2|refseq:NP_071887.1|refseq:NP_954595.1|refseq:NP_954673.1|refseq:NP_001244322.1|refseq:NP_001244323.1|refseq:NP_001244325.1|ensembl:ENSG00000244687(gene)|ensembl:ENST00000371674(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006282"(regulation of DNA repair)|go:"GO:0006301"(postreplication repair)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0030154"(cell differentiation)|go:"GO:0031371"(ubiquitin conjugating enzyme complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035370"(UBC13-UEV1A complex)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070534"(protein K63-linked ubiquitination)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|rcsb pdb:2A4D|rcsb pdb:2C2V|rcsb pdb:2HLW|rcsb pdb:6D6I|reactome:R-HSA-168638|reactome:R-HSA-168927|reactome:R-HSA-202424|reactome:R-HSA-2871837|reactome:R-HSA-445989|reactome:R-HSA-450302|reactome:R-HSA-450321|reactome:R-HSA-5607764|reactome:R-HSA-9020702|reactome:R-HSA-937039|reactome:R-HSA-937041|reactome:R-HSA-9646399|reactome:R-HSA-975110|reactome:R-HSA-975144|reactome:R-HSA-983168|dip:DIP-41911N	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S2|caution:"UBE2N has been marked as the enzyme in this assay, although it is the UBE2N-UBE2V1 complex that has ubiquitinase (E3) activity. Neither UBE2N nor UBE2V1 have E2 or E3 activity on their own."|resulting-ptm:P61077 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:jSQ4I+Cgli7HaN5S0OLUP+J5YXs9606	rogid:x95N7Dj2KIqu5gySX59xLmfthUg9606	intact-crc:344BDBB0AEE7790E|rigid:YCwIJqUspXLwxwe9dCi1DWxZU4c	false	-	his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P61077	uniprotkb:P22314	intact:EBI-348268|ensembl:ENSP00000318494|ensembl:ENSP00000337208|ensembl:ENSP00000378283|ensembl:ENSP00000396901|ensembl:ENSP00000344069|ensembl:ENSP00000378280|ensembl:ENSP00000378282|uniprotkb:A6NM99|intact:EBI-2809412|uniprotkb:P47986|uniprotkb:Q6IB88|uniprotkb:Q6NXS4|uniprotkb:Q8N924|uniprotkb:A6NJ93|uniprotkb:A6NJB1	intact:EBI-709688|uniprotkb:Q96E13|uniprotkb:Q5JRR8|ensembl:ENSP00000338413|ensembl:ENSP00000366568	psi-mi:ub2d3_human(display_long)|uniprotkb:UBC5C(gene name synonym)|uniprotkb:Ubiquitin-protein ligase D3(gene name synonym)|uniprotkb:Ubiquitin carrier protein D3(gene name synonym)|uniprotkb:Ubiquitin-conjugating enzyme E2-17 kDa 3(gene name synonym)|uniprotkb:"Ubiquitin-conjugating enzyme E2(17)KB 3"(gene name synonym)|uniprotkb:UBE2D3(gene name)|psi-mi:UBE2D3(display_short)|uniprotkb:UBCH5C(gene name synonym)|uniprotkb:"(E3-independent) E2 ubiquitin-conjugating enzyme D3"(gene name synonym)|uniprotkb:E2 ubiquitin-conjugating enzyme D3(gene name synonym)	psi-mi:uba1_human(display_long)|uniprotkb:Ubiquitin-activating enzyme E1(gene name synonym)|uniprotkb:Protein A1S9(gene name synonym)|uniprotkb:UBA1(gene name)|psi-mi:UBA1(display_short)|uniprotkb:A1S9T(gene name synonym)|uniprotkb:UBE1(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9970388|imex:IM-22822-23	author-confidence:Z-score = 5.72	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000109332(gene)|ensembl:ENST00000321805(transcript)|ensembl:ENST00000338145(transcript)|ensembl:ENST00000349311(transcript)|ensembl:ENST00000394801(transcript)|ensembl:ENST00000394803(transcript)|ensembl:ENST00000394804(transcript)|ensembl:ENST00000453744(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006281"(DNA repair)|go:"GO:0006513"(protein monoubiquitination)|go:"GO:0006915"(apoptotic process)|go:"GO:0010008"(endosome membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0006464"(cellular protein modification process)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0061631"(ubiquitin conjugating enzyme activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070936"(protein K48-linked ubiquitination)|go:"GO:0070979"(protein K11-linked ubiquitination)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0071288"(cellular response to mercury ion)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|interpro:IPR023313|rcsb pdb:2FUH|rcsb pdb:3L1Z|rcsb pdb:3RPG|rcsb pdb:3UGB|rcsb pdb:4BVU|rcsb pdb:4R8P|rcsb pdb:4S3O|rcsb pdb:5EGG|rcsb pdb:5IFR|rcsb pdb:6CP0|rcsb pdb:6T7F|rcsb pdb:7JZV|reactome:R-HSA-1234176|reactome:R-HSA-168927|reactome:R-HSA-201451|reactome:R-HSA-2173795|reactome:R-HSA-8866654|reactome:R-HSA-8951664|reactome:R-HSA-9033241|reactome:R-HSA-936440|reactome:R-HSA-937041|reactome:R-HSA-9705462|reactome:R-HSA-983168|rcsb pdb:1X23|refseq:NP_003331.1|refseq:NP_871615.1|refseq:NP_871616.1|refseq:NP_871617.1|refseq:NP_871618.1|refseq:NP_871619.1|refseq:NP_871620.1|refseq:NP_871621.1|refseq:NP_871622.1|dip:DIP-29062N	refseq:NP_003325.2|refseq:NP_695012.1|refseq:XP_016885269.1|refseq:XP_016885270.1|dip:DIP-33686N|ensembl:ENSG00000130985(gene)|ensembl:ENST00000335972(transcript)|ensembl:ENST00000377351(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0004839"(ubiquitin activating enzyme activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0032446"(protein modification by small protein conjugation)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000011(Ubiquitin-activating enzyme, E1)|interpro:IPR000594(UBA/THIF-type NAD/FAD binding fold)|interpro:IPR018074|interpro:IPR018075|interpro:IPR018965|interpro:IPR019572|interpro:IPR032418|interpro:IPR032420|interpro:IPR033127|interpro:IPR035985|interpro:IPR038252|interpro:IPR042063|interpro:IPR042302|interpro:IPR042449|mint:P22314|rcsb pdb:4P22|rcsb pdb:6DC6|reactome:R-HSA-8866652|reactome:R-HSA-983168	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S2|caution:"UBE2N has been marked as the enzyme in this assay, although it is the UBE2N-UBE2V1 complex that has ubiquitinase (E3) activity. Neither UBE2N nor UBE2V1 have E2 or E3 activity on their own."|resulting-ptm:P61077 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:jSQ4I+Cgli7HaN5S0OLUP+J5YXs9606	rogid:q+vEeA0XLST0Zz173bmEt0dNbDE9606	intact-crc:344BDBB0AEE7790E|rigid:YCwIJqUspXLwxwe9dCi1DWxZU4c	false	-	his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P61077	uniprotkb:P61088	intact:EBI-348268|ensembl:ENSP00000318494|ensembl:ENSP00000337208|ensembl:ENSP00000378283|ensembl:ENSP00000396901|ensembl:ENSP00000344069|ensembl:ENSP00000378280|ensembl:ENSP00000378282|uniprotkb:A6NM99|intact:EBI-2809412|uniprotkb:P47986|uniprotkb:Q6IB88|uniprotkb:Q6NXS4|uniprotkb:Q8N924|uniprotkb:A6NJ93|uniprotkb:A6NJB1	intact:EBI-1052908|uniprotkb:Q16781|uniprotkb:Q53Y81|ensembl:ENSP00000316176	psi-mi:ub2d3_human(display_long)|uniprotkb:UBC5C(gene name synonym)|uniprotkb:Ubiquitin-protein ligase D3(gene name synonym)|uniprotkb:Ubiquitin carrier protein D3(gene name synonym)|uniprotkb:Ubiquitin-conjugating enzyme E2-17 kDa 3(gene name synonym)|uniprotkb:"Ubiquitin-conjugating enzyme E2(17)KB 3"(gene name synonym)|uniprotkb:UBE2D3(gene name)|psi-mi:UBE2D3(display_short)|uniprotkb:UBCH5C(gene name synonym)|uniprotkb:"(E3-independent) E2 ubiquitin-conjugating enzyme D3"(gene name synonym)|uniprotkb:E2 ubiquitin-conjugating enzyme D3(gene name synonym)	psi-mi:ube2n_human(display_long)|uniprotkb:Ubiquitin-protein ligase N(gene name synonym)|uniprotkb:Ubiquitin carrier protein N(gene name synonym)|uniprotkb:Ubc13(gene name synonym)|uniprotkb:Bendless-like ubiquitin-conjugating enzyme(gene name synonym)|uniprotkb:UBE2N(gene name)|psi-mi:UBE2N(display_short)|uniprotkb:BLU(gene name synonym)|uniprotkb:UbcH13(gene name synonym)|uniprotkb:E2 ubiquitin-conjugating enzyme N(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9970388|imex:IM-22822-23	author-confidence:Z-score = 5.72	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000109332(gene)|ensembl:ENST00000321805(transcript)|ensembl:ENST00000338145(transcript)|ensembl:ENST00000349311(transcript)|ensembl:ENST00000394801(transcript)|ensembl:ENST00000394803(transcript)|ensembl:ENST00000394804(transcript)|ensembl:ENST00000453744(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006281"(DNA repair)|go:"GO:0006513"(protein monoubiquitination)|go:"GO:0006915"(apoptotic process)|go:"GO:0010008"(endosome membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0006464"(cellular protein modification process)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0061631"(ubiquitin conjugating enzyme activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070936"(protein K48-linked ubiquitination)|go:"GO:0070979"(protein K11-linked ubiquitination)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0071288"(cellular response to mercury ion)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|interpro:IPR023313|rcsb pdb:2FUH|rcsb pdb:3L1Z|rcsb pdb:3RPG|rcsb pdb:3UGB|rcsb pdb:4BVU|rcsb pdb:4R8P|rcsb pdb:4S3O|rcsb pdb:5EGG|rcsb pdb:5IFR|rcsb pdb:6CP0|rcsb pdb:6T7F|rcsb pdb:7JZV|reactome:R-HSA-1234176|reactome:R-HSA-168927|reactome:R-HSA-201451|reactome:R-HSA-2173795|reactome:R-HSA-8866654|reactome:R-HSA-8951664|reactome:R-HSA-9033241|reactome:R-HSA-936440|reactome:R-HSA-937041|reactome:R-HSA-9705462|reactome:R-HSA-983168|rcsb pdb:1X23|refseq:NP_003331.1|refseq:NP_871615.1|refseq:NP_871616.1|refseq:NP_871617.1|refseq:NP_871618.1|refseq:NP_871619.1|refseq:NP_871620.1|refseq:NP_871621.1|refseq:NP_871622.1|dip:DIP-29062N	refseq:NP_003339.1|dip:DIP-29829N|ensembl:ENSG00000177889(gene)|ensembl:ENST00000318066(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000729"(DNA double-strand break processing)|go:"GO:0001650"(fibrillar center)|go:"GO:0003723"(RNA binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006282"(regulation of DNA repair)|go:"GO:0006301"(postreplication repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016574"(histone ubiquitination)|go:"GO:0031058"(positive regulation of histone modification)|go:"GO:0031372"(UBC13-MMS2 complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033182"(regulation of histone ubiquitination)|go:"GO:0035370"(UBC13-UEV1A complex)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0061631"(ubiquitin conjugating enzyme activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070534"(protein K63-linked ubiquitination)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|interpro:IPR023313|rcsb pdb:1J7D|rcsb pdb:2C2V|rcsb pdb:3HCT|rcsb pdb:3HCU|rcsb pdb:3VON|rcsb pdb:3W31|rcsb pdb:4DHI|rcsb pdb:4DHJ|rcsb pdb:4DHZ|rcsb pdb:4IP3|rcsb pdb:4NR3|rcsb pdb:4NRG|rcsb pdb:4NRI|rcsb pdb:4ONL|rcsb pdb:4ONM|rcsb pdb:4ONN|rcsb pdb:4ORH|rcsb pdb:4TKP|rcsb pdb:4WHV|rcsb pdb:5AIT|rcsb pdb:5AIU|rcsb pdb:5EYA|rcsb pdb:5H7S|rcsb pdb:5VNZ|rcsb pdb:5VO0|rcsb pdb:5YWR|rcsb pdb:6D6I|rcsb pdb:6JKY|rcsb pdb:6KFP|rcsb pdb:6KG6|rcsb pdb:6KL4|rcsb pdb:6LP2|rcsb pdb:6P5B|rcsb pdb:6S53|reactome:R-HSA-168927|reactome:R-HSA-202424|reactome:R-HSA-2871837|reactome:R-HSA-445989|reactome:R-HSA-450302|reactome:R-HSA-450321|reactome:R-HSA-5607764|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-5696395|reactome:R-HSA-69473|reactome:R-HSA-8866654|reactome:R-HSA-9020702|reactome:R-HSA-937039|reactome:R-HSA-937041|reactome:R-HSA-9646399|reactome:R-HSA-975110|reactome:R-HSA-975144|reactome:R-HSA-983168|rcsb pdb:6ULH|rcsb pdb:6UMP|rcsb pdb:6UMS|rcsb pdb:7BBD|rcsb pdb:7BBF|rcsb pdb:7BXG|reactome:R-HSA-1169408|reactome:R-HSA-168638	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S2|caution:"UBE2N has been marked as the enzyme in this assay, although it is the UBE2N-UBE2V1 complex that has ubiquitinase (E3) activity. Neither UBE2N nor UBE2V1 have E2 or E3 activity on their own."|resulting-ptm:P61077 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:jSQ4I+Cgli7HaN5S0OLUP+J5YXs9606	rogid:dqdszHlq5FLPHC6UWX6uvkC6Yz89606	intact-crc:344BDBB0AEE7790E|rigid:YCwIJqUspXLwxwe9dCi1DWxZU4c	false	-	his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P53370	uniprotkb:Q13404	intact:EBI-2689052|uniprotkb:A8K756|uniprotkb:Q9UQD9|uniprotkb:O95097|ensembl:ENSP00000306070	intact:EBI-1050671|uniprotkb:Q13403|uniprotkb:Q13532|uniprotkb:Q96H34|uniprotkb:Q9GZT0|uniprotkb:Q9GZW1|uniprotkb:Q9H4J3|uniprotkb:Q9H4J4|uniprotkb:Q9UKL1|uniprotkb:Q9UM48|uniprotkb:Q9UM49|uniprotkb:Q9UM50|uniprotkb:Q5TGE3|uniprotkb:E1P629|uniprotkb:Q5TGE0|ensembl:ENSP00000360739	psi-mi:nudt6_human(display_long)|uniprotkb:FGF2AS(gene name synonym)|uniprotkb:Antisense basic fibroblast growth factor(gene name synonym)|uniprotkb:Protein GFG(gene name synonym)|uniprotkb:NUDT6(gene name)|psi-mi:NUDT6(display_short)	psi-mi:ub2v1_human(display_long)|uniprotkb:CROC-1(gene name synonym)|uniprotkb:TRAF6-regulated IKK activator 1 beta Uev1A(gene name synonym)|uniprotkb:P/OKcl.19(orf name)|uniprotkb:UBE2V1(gene name)|psi-mi:UBE2V1(display_short)|uniprotkb:CROC1(gene name synonym)|uniprotkb:UBE2V(gene name synonym)|uniprotkb:UEV1(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9970367|imex:IM-22822-22	author-confidence:Z-score = 11.54	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_009014.2|refseq:NP_932158.1|ensembl:ENSG00000170917(gene)|ensembl:ENST00000304430(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0035529"(NADH pyrophosphatase activity)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0047631"(ADP-ribose diphosphatase activity)|go:"GO:0051287"(NAD binding)|interpro:IPR000086(NUDIX hydrolase, core)|interpro:IPR003293(Anti-sense to fibroblast growth factor protein GFG)|interpro:IPR015797(NUDIX)|interpro:IPR020084|interpro:IPR040618|rcsb pdb:3FXT|rcsb pdb:3H95	refseq:NP_001027459.1|refseq:NP_068823.2|refseq:NP_071887.1|refseq:NP_954595.1|refseq:NP_954673.1|refseq:NP_001244322.1|refseq:NP_001244323.1|refseq:NP_001244325.1|ensembl:ENSG00000244687(gene)|ensembl:ENST00000371674(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006282"(regulation of DNA repair)|go:"GO:0006301"(postreplication repair)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0030154"(cell differentiation)|go:"GO:0031371"(ubiquitin conjugating enzyme complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035370"(UBC13-UEV1A complex)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070534"(protein K63-linked ubiquitination)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|rcsb pdb:2A4D|rcsb pdb:2C2V|rcsb pdb:2HLW|rcsb pdb:6D6I|reactome:R-HSA-168638|reactome:R-HSA-168927|reactome:R-HSA-202424|reactome:R-HSA-2871837|reactome:R-HSA-445989|reactome:R-HSA-450302|reactome:R-HSA-450321|reactome:R-HSA-5607764|reactome:R-HSA-9020702|reactome:R-HSA-937039|reactome:R-HSA-937041|reactome:R-HSA-9646399|reactome:R-HSA-975110|reactome:R-HSA-975144|reactome:R-HSA-983168|dip:DIP-41911N	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S2|caution:"UBE2N has been marked as the enzyme in this assay, although it is the UBE2N-UBE2V1 complex that has ubiquitinase (E3) activity. Neither UBE2N nor UBE2V1 have E2 or E3 activity on their own."|resulting-ptm:P53370 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:MtDzKCF+qq700+gHJgdnfoZXq9o9606	rogid:x95N7Dj2KIqu5gySX59xLmfthUg9606	intact-crc:8E0B40544DCF00A6|rigid:UW2TZwVUTPYUydPEzJNHXtWNd/s	false	-	his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P53370	uniprotkb:P22314	intact:EBI-2689052|uniprotkb:A8K756|uniprotkb:Q9UQD9|uniprotkb:O95097|ensembl:ENSP00000306070	intact:EBI-709688|uniprotkb:Q96E13|uniprotkb:Q5JRR8|ensembl:ENSP00000338413|ensembl:ENSP00000366568	psi-mi:nudt6_human(display_long)|uniprotkb:FGF2AS(gene name synonym)|uniprotkb:Antisense basic fibroblast growth factor(gene name synonym)|uniprotkb:Protein GFG(gene name synonym)|uniprotkb:NUDT6(gene name)|psi-mi:NUDT6(display_short)	psi-mi:uba1_human(display_long)|uniprotkb:Ubiquitin-activating enzyme E1(gene name synonym)|uniprotkb:Protein A1S9(gene name synonym)|uniprotkb:UBA1(gene name)|psi-mi:UBA1(display_short)|uniprotkb:A1S9T(gene name synonym)|uniprotkb:UBE1(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9970367|imex:IM-22822-22	author-confidence:Z-score = 11.54	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_009014.2|refseq:NP_932158.1|ensembl:ENSG00000170917(gene)|ensembl:ENST00000304430(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0035529"(NADH pyrophosphatase activity)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0047631"(ADP-ribose diphosphatase activity)|go:"GO:0051287"(NAD binding)|interpro:IPR000086(NUDIX hydrolase, core)|interpro:IPR003293(Anti-sense to fibroblast growth factor protein GFG)|interpro:IPR015797(NUDIX)|interpro:IPR020084|interpro:IPR040618|rcsb pdb:3FXT|rcsb pdb:3H95	refseq:NP_003325.2|refseq:NP_695012.1|refseq:XP_016885269.1|refseq:XP_016885270.1|dip:DIP-33686N|ensembl:ENSG00000130985(gene)|ensembl:ENST00000335972(transcript)|ensembl:ENST00000377351(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0004839"(ubiquitin activating enzyme activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0032446"(protein modification by small protein conjugation)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000011(Ubiquitin-activating enzyme, E1)|interpro:IPR000594(UBA/THIF-type NAD/FAD binding fold)|interpro:IPR018074|interpro:IPR018075|interpro:IPR018965|interpro:IPR019572|interpro:IPR032418|interpro:IPR032420|interpro:IPR033127|interpro:IPR035985|interpro:IPR038252|interpro:IPR042063|interpro:IPR042302|interpro:IPR042449|mint:P22314|rcsb pdb:4P22|rcsb pdb:6DC6|reactome:R-HSA-8866652|reactome:R-HSA-983168	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S2|caution:"UBE2N has been marked as the enzyme in this assay, although it is the UBE2N-UBE2V1 complex that has ubiquitinase (E3) activity. Neither UBE2N nor UBE2V1 have E2 or E3 activity on their own."|resulting-ptm:P53370 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:MtDzKCF+qq700+gHJgdnfoZXq9o9606	rogid:q+vEeA0XLST0Zz173bmEt0dNbDE9606	intact-crc:8E0B40544DCF00A6|rigid:UW2TZwVUTPYUydPEzJNHXtWNd/s	false	-	his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P53370	uniprotkb:P61088	intact:EBI-2689052|uniprotkb:A8K756|uniprotkb:Q9UQD9|uniprotkb:O95097|ensembl:ENSP00000306070	intact:EBI-1052908|uniprotkb:Q16781|uniprotkb:Q53Y81|ensembl:ENSP00000316176	psi-mi:nudt6_human(display_long)|uniprotkb:FGF2AS(gene name synonym)|uniprotkb:Antisense basic fibroblast growth factor(gene name synonym)|uniprotkb:Protein GFG(gene name synonym)|uniprotkb:NUDT6(gene name)|psi-mi:NUDT6(display_short)	psi-mi:ube2n_human(display_long)|uniprotkb:Ubiquitin-protein ligase N(gene name synonym)|uniprotkb:Ubiquitin carrier protein N(gene name synonym)|uniprotkb:Ubc13(gene name synonym)|uniprotkb:Bendless-like ubiquitin-conjugating enzyme(gene name synonym)|uniprotkb:UBE2N(gene name)|psi-mi:UBE2N(display_short)|uniprotkb:BLU(gene name synonym)|uniprotkb:UbcH13(gene name synonym)|uniprotkb:E2 ubiquitin-conjugating enzyme N(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9970367|imex:IM-22822-22	author-confidence:Z-score = 11.54	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_009014.2|refseq:NP_932158.1|ensembl:ENSG00000170917(gene)|ensembl:ENST00000304430(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0035529"(NADH pyrophosphatase activity)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0047631"(ADP-ribose diphosphatase activity)|go:"GO:0051287"(NAD binding)|interpro:IPR000086(NUDIX hydrolase, core)|interpro:IPR003293(Anti-sense to fibroblast growth factor protein GFG)|interpro:IPR015797(NUDIX)|interpro:IPR020084|interpro:IPR040618|rcsb pdb:3FXT|rcsb pdb:3H95	refseq:NP_003339.1|dip:DIP-29829N|ensembl:ENSG00000177889(gene)|ensembl:ENST00000318066(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000729"(DNA double-strand break processing)|go:"GO:0001650"(fibrillar center)|go:"GO:0003723"(RNA binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006282"(regulation of DNA repair)|go:"GO:0006301"(postreplication repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016574"(histone ubiquitination)|go:"GO:0031058"(positive regulation of histone modification)|go:"GO:0031372"(UBC13-MMS2 complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033182"(regulation of histone ubiquitination)|go:"GO:0035370"(UBC13-UEV1A complex)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0061631"(ubiquitin conjugating enzyme activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070534"(protein K63-linked ubiquitination)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|interpro:IPR023313|rcsb pdb:1J7D|rcsb pdb:2C2V|rcsb pdb:3HCT|rcsb pdb:3HCU|rcsb pdb:3VON|rcsb pdb:3W31|rcsb pdb:4DHI|rcsb pdb:4DHJ|rcsb pdb:4DHZ|rcsb pdb:4IP3|rcsb pdb:4NR3|rcsb pdb:4NRG|rcsb pdb:4NRI|rcsb pdb:4ONL|rcsb pdb:4ONM|rcsb pdb:4ONN|rcsb pdb:4ORH|rcsb pdb:4TKP|rcsb pdb:4WHV|rcsb pdb:5AIT|rcsb pdb:5AIU|rcsb pdb:5EYA|rcsb pdb:5H7S|rcsb pdb:5VNZ|rcsb pdb:5VO0|rcsb pdb:5YWR|rcsb pdb:6D6I|rcsb pdb:6JKY|rcsb pdb:6KFP|rcsb pdb:6KG6|rcsb pdb:6KL4|rcsb pdb:6LP2|rcsb pdb:6P5B|rcsb pdb:6S53|reactome:R-HSA-168927|reactome:R-HSA-202424|reactome:R-HSA-2871837|reactome:R-HSA-445989|reactome:R-HSA-450302|reactome:R-HSA-450321|reactome:R-HSA-5607764|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-5696395|reactome:R-HSA-69473|reactome:R-HSA-8866654|reactome:R-HSA-9020702|reactome:R-HSA-937039|reactome:R-HSA-937041|reactome:R-HSA-9646399|reactome:R-HSA-975110|reactome:R-HSA-975144|reactome:R-HSA-983168|rcsb pdb:6ULH|rcsb pdb:6UMP|rcsb pdb:6UMS|rcsb pdb:7BBD|rcsb pdb:7BBF|rcsb pdb:7BXG|reactome:R-HSA-1169408|reactome:R-HSA-168638	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S2|caution:"UBE2N has been marked as the enzyme in this assay, although it is the UBE2N-UBE2V1 complex that has ubiquitinase (E3) activity. Neither UBE2N nor UBE2V1 have E2 or E3 activity on their own."|resulting-ptm:P53370 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:MtDzKCF+qq700+gHJgdnfoZXq9o9606	rogid:dqdszHlq5FLPHC6UWX6uvkC6Yz89606	intact-crc:8E0B40544DCF00A6|rigid:UW2TZwVUTPYUydPEzJNHXtWNd/s	false	-	his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P62158	uniprotkb:Q13404	intact:EBI-397435|uniprotkb:P02593|uniprotkb:P70667|uniprotkb:P99014|uniprotkb:Q13942|uniprotkb:Q53S29|uniprotkb:Q61379|uniprotkb:Q61380|uniprotkb:Q96HK3|uniprotkb:P0DP25|uniprotkb:P0DP24|uniprotkb:P0DP23	intact:EBI-1050671|uniprotkb:Q13403|uniprotkb:Q13532|uniprotkb:Q96H34|uniprotkb:Q9GZT0|uniprotkb:Q9GZW1|uniprotkb:Q9H4J3|uniprotkb:Q9H4J4|uniprotkb:Q9UKL1|uniprotkb:Q9UM48|uniprotkb:Q9UM49|uniprotkb:Q9UM50|uniprotkb:Q5TGE3|uniprotkb:E1P629|uniprotkb:Q5TGE0|ensembl:ENSP00000360739	psi-mi:calm_human(display_long)|uniprotkb:CALM1(gene name)|psi-mi:CALM1(display_short)|uniprotkb:CALM(gene name synonym)|uniprotkb:CAM(gene name synonym)|uniprotkb:CAM1(gene name synonym)|uniprotkb:CALM2(gene name)|psi-mi:CALM2(display_short)|uniprotkb:CAMB(gene name synonym)|uniprotkb:CALM3(gene name)|psi-mi:CALM3(display_short)|uniprotkb:CAM3(gene name synonym)|uniprotkb:CAMC(gene name synonym)|uniprotkb:CAMIII(gene name synonym)|uniprotkb:CAM2(gene name synonym)|uniprotkb:CALML2(gene name synonym)	psi-mi:ub2v1_human(display_long)|uniprotkb:CROC-1(gene name synonym)|uniprotkb:TRAF6-regulated IKK activator 1 beta Uev1A(gene name synonym)|uniprotkb:P/OKcl.19(orf name)|uniprotkb:UBE2V1(gene name)|psi-mi:UBE2V1(display_short)|uniprotkb:CROC1(gene name synonym)|uniprotkb:UBE2V(gene name synonym)|uniprotkb:UEV1(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9970409|imex:IM-22822-24	author-confidence:Z-score = 4.27	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rcsb pdb:3SUI|rcsb pdb:2LGF|rcsb pdb:2LQC|rcsb pdb:2LQP|rcsb pdb:2Y4V|rcsb pdb:4JQ0|rcsb pdb:4LZX|rcsb pdb:4M1L|go:"GO:0010800"(positive regulation of peptidyl-threonine phosphorylation)|rcsb pdb:3J41|rcsb pdb:2LL6|go:"GO:0002027"(regulation of heart rate)|go:"GO:0005513"(detection of calcium ion)|go:"GO:0010881"(regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion)|go:"GO:0030017"(sarcomere)|go:"GO:0030801"(obsolete positive regulation of cyclic nucleotide metabolic process)|go:"GO:0032516"(positive regulation of phosphoprotein phosphatase activity)|go:"GO:0035307"(positive regulation of protein dephosphorylation)|go:"GO:0051343"(positive regulation of cyclic-nucleotide phosphodiesterase activity)|go:"GO:0072542"(protein phosphatase activator activity)|go:"GO:1901844"(regulation of cell communication by electrical coupling involved in cardiac conduction)|rcsb pdb:2LV6|rcsb pdb:2N6A|refseq:NP_001734.1|refseq:NP_005175.2|refseq:NP_008819.1|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|interpro:IPR002048(Calcium-binding EF-hand)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005876"(spindle microtubule)|go:"GO:0000922"(spindle pole)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005980"(glycogen catabolic process)|go:"GO:0006936"(muscle contraction)|go:"GO:0060315"(negative regulation of ryanodine-sensitive calcium-release channel activity)|go:"GO:0002576"(platelet degranulation)|go:"GO:0060316"(positive regulation of ryanodine-sensitive calcium-release channel activity)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0050999"(regulation of nitric-oxide synthase activity)|rcsb pdb:1AJI|rcsb pdb:1CDL|rcsb pdb:1CLL|rcsb pdb:1CTR|rcsb pdb:1IWQ|rcsb pdb:1J7O|rcsb pdb:1J7P|rcsb pdb:1K90|rcsb pdb:1K93|rcsb pdb:1L7Z|rcsb pdb:1LVC|rcsb pdb:1NKF|rcsb pdb:1PK0|rcsb pdb:1S26|rcsb pdb:1SK6|rcsb pdb:1SW8|rcsb pdb:1WRZ|rcsb pdb:1XFU|rcsb pdb:1XFV|rcsb pdb:1XFW|rcsb pdb:1XFX|rcsb pdb:1XFY|rcsb pdb:1XFZ|rcsb pdb:1Y6W|rcsb pdb:1YR5|rcsb pdb:1YRT|rcsb pdb:1YRU|rcsb pdb:1ZOT|rcsb pdb:1ZUZ|rcsb pdb:2BE6|rcsb pdb:2F3Y|rcsb pdb:2F3Z|rcsb pdb:2HF5|rcsb pdb:2I08|rcsb pdb:2JZI|rcsb pdb:2K0E|rcsb pdb:2K0F|rcsb pdb:2K0J|rcsb pdb:2K61|rcsb pdb:2KNE|rcsb pdb:2KUG|rcsb pdb:2KUH|rcsb pdb:2L53|rcsb pdb:2L7L|rcsb pdb:2R28|rcsb pdb:2V01|rcsb pdb:2V02|rcsb pdb:2VAY|rcsb pdb:2W73|rcsb pdb:2WEL|rcsb pdb:2X0G|rcsb pdb:3BYA|rcsb pdb:3DVE|rcsb pdb:3DVJ|rcsb pdb:3DVK|rcsb pdb:3DVM|rcsb pdb:3EWT|rcsb pdb:3EWV|rcsb pdb:3G43|rcsb pdb:3HR4|rcsb pdb:3O77|rcsb pdb:3O78|rcsb pdb:3OXQ|rcsb pdb:3UCT|rcsb pdb:3UCW|rcsb pdb:3UCY|rcsb pdb:4DCK|go:"GO:0010801"(negative regulation of peptidyl-threonine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031954"(positive regulation of protein autophosphorylation)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0000165"(MAPK cascade)|rcsb pdb:2M0J|rcsb pdb:2M0K|rcsb pdb:4UMO|rcsb pdb:4V0C|go:"GO:0031982"(vesicle)|rcsb pdb:4Q5U|rcsb pdb:4UPU|reactome:R-HSA-2672351|reactome:R-HSA-418359|reactome:R-HSA-425561|reactome:R-HSA-5576892|reactome:R-HSA-5578775|reactome:R-HSA-936837|refseq:NP_001292555.1|rcsb pdb:4OVN|rcsb pdb:5COC|go:"GO:0021762"(substantia nigra development)|go:"GO:0070062"(extracellular exosome)|rcsb pdb:4BW7|rcsb pdb:4BW8|rcsb pdb:4L79|rcsb pdb:5DBR|rcsb pdb:4DJC|rcsb pdb:2M55|rcsb pdb:2LL7|go:"GO:0019855"(calcium channel inhibitor activity)|go:"GO:0001975"(response to amphetamine)|go:"GO:0007190"(activation of adenylate cyclase activity)|go:"GO:0030235"(nitric-oxide synthase regulator activity)|go:"GO:0030426"(growth cone)|go:"GO:0051000"(positive regulation of nitric-oxide synthase activity)|go:"GO:0051412"(response to corticosterone)|go:"GO:1901841"(regulation of high voltage-gated calcium channel activity)|rcsb pdb:2N77|go:"GO:0032991"(protein-containing complex)|go:"GO:0006479"(protein methylation)|go:"GO:0014069"(postsynaptic density)|rcsb pdb:5DSU|reactome:R-HSA-8876725|rcsb pdb:4GOW|rcsb pdb:4Q57|go:"GO:0043647"(inositol phosphate metabolic process)|go:"GO:0022400"(regulation of rhodopsin mediated signaling pathway)|go:"GO:0038095"(Fc-epsilon receptor signaling pathway)|go:"GO:0005576"(extracellular region)|go:"GO:0005737"(cytoplasm)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0010880"(regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0031432"(titin binding)|go:"GO:0031996"(thioesterase binding)|go:"GO:0031997"(N-terminal myristoylation domain binding)|go:"GO:0043274"(phospholipase binding)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0051592"(response to calcium ion)|go:"GO:0055117"(regulation of cardiac muscle contraction)|rcsb pdb:2MG5|go:"GO:0005088"|go:"GO:0007223"(Wnt signaling pathway, calcium modulating pathway)|go:"GO:0008440"(inositol-1,4,5-trisphosphate 3-kinase activity)|go:"GO:0015276"(ligand-gated ion channel activity)|go:"GO:0005634"(nucleus)|rcsb pdb:4JPZ|ensembl:ENST00000272298|ensembl:ENST00000291295|ensembl:ENST00000356978|ensembl:ENST00000596362|refseq:NP_001292553.1|refseq:NP_001292554.1|rcsb pdb:4BYF|reactome:R-HSA-111932|reactome:R-HSA-111933|reactome:R-HSA-111957|reactome:R-HSA-111997|reactome:R-HSA-114608|reactome:R-HSA-1445148|reactome:R-HSA-1474151|reactome:R-HSA-180024|reactome:R-HSA-1855204|reactome:R-HSA-203615|reactome:R-HSA-2514859|reactome:R-HSA-2871809|reactome:R-HSA-4086398|reactome:R-HSA-442717|reactome:R-HSA-442729|reactome:R-HSA-442745|reactome:R-HSA-442982|reactome:R-HSA-445355|reactome:R-HSA-451308|reactome:R-HSA-5218920|reactome:R-HSA-5218921|reactome:R-HSA-5607763|reactome:R-HSA-5626467|reactome:R-HSA-5627123|reactome:R-HSA-5673001|reactome:R-HSA-70221|reactome:R-HSA-983695|ensembl:ENSG00000143933|ensembl:ENSG00000160014|ensembl:ENSG00000198668|ensembl:ENSP00000272298|ensembl:ENSP00000291295|ensembl:ENSP00000349467|ensembl:ENSP00000472141|rcsb pdb:5NIN|rcsb pdb:5VMS|rcsb pdb:5WSU|rcsb pdb:5WSV|rcsb pdb:6U39|rcsb pdb:6U3A|rcsb pdb:6U3B|rcsb pdb:6U3D|rcsb pdb:2N8J|rcsb pdb:5GGM|rcsb pdb:5J8H|reactome:R-HSA-163615|reactome:R-HSA-5210891|refseq:NP_001316851.1|refseq:NP_001316852.1|refseq:NP_001316853.1|refseq:NP_001316854.1|refseq:NP_001316855.1|rcsb pdb:2N27|rcsb pdb:5DOW|rcsb pdb:5I0I|rcsb pdb:5J03|rcsb pdb:5K7L|rcsb pdb:5K8Q|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0000086"(G2/M transition of mitotic cell cycle)|go:"GO:0043388"(positive regulation of DNA binding)|dip:DIP-31794N|rcsb pdb:1UP5|rcsb pdb:5JQA|rcsb pdb:5JTH|rcsb pdb:5OEO|rcsb pdb:5TP5|rcsb pdb:5TP6|rcsb pdb:5V02|rcsb pdb:5V03|rcsb pdb:5V7X|rcsb pdb:5WBX|rcsb pdb:5WC5|rcsb pdb:6B8L|rcsb pdb:6B8M|rcsb pdb:6B8N|rcsb pdb:6B8P|rcsb pdb:6B8Q|rcsb pdb:6C1D|rcsb pdb:6C1G|rcsb pdb:6C1H|rcsb pdb:6CNM|rcsb pdb:6CNN|rcsb pdb:6CNO|rcsb pdb:6FEG|rcsb pdb:6FEH|reactome:R-HSA-2025928|reactome:R-HSA-2151201|go:"GO:0034704"(calcium channel complex)|go:"GO:0010856"(adenylate cyclase activator activity)|go:"GO:0051186"(obsolete cofactor metabolic process)|go:"GO:0075206"(obsolete positive regulation by host of symbiont cAMP-mediated signal transduction)|go:"GO:0060314"(regulation of ryanodine-sensitive calcium-release channel activity)|interpro:IPR039030|go:"GO:1902494"(catalytic complex)|go:"GO:0043234"|go:"GO:0008179"(adenylate cyclase binding)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0030819"(obsolete positive regulation of cAMP biosynthetic process)|rcsb pdb:6BUT|rcsb pdb:6DAD|rcsb pdb:6DAE|rcsb pdb:6DAF|rcsb pdb:6DAH|rcsb pdb:6E2F|rcsb pdb:6E2G|rcsb pdb:6EEB|rcsb pdb:6GDK|rcsb pdb:6GDL|rcsb pdb:6HCS|rcsb pdb:6JI8|rcsb pdb:6JII|rcsb pdb:6JIU|rcsb pdb:6JIY|rcsb pdb:6JRS|rcsb pdb:6JV2|rcsb pdb:6K4K|rcsb pdb:6K4L|rcsb pdb:6K4R|rcsb pdb:6MUD|rcsb pdb:6MUE|rcsb pdb:6N5W|rcsb pdb:6O5G|reactome:R-HSA-438066|reactome:R-HSA-442720|reactome:R-HSA-5673000|reactome:R-HSA-6802946|reactome:R-HSA-6802949|reactome:R-HSA-6802952|reactome:R-HSA-6802955|reactome:R-HSA-9009391|reactome:R-HSA-9022535|reactome:R-HSA-9022692|reactome:R-HSA-9617324|reactome:R-HSA-9619229|reactome:R-HSA-9619483|reactome:R-HSA-9620244|go:"GO:0019722"(calcium-mediated signaling)|rcsb pdb:6PBX|rcsb pdb:6PBY|reactome:R-HSA-9649948|go:"GO:0005623"(obsolete cell)|rcsb pdb:6HR1|rcsb pdb:6OS4|rcsb pdb:6Y4P|rcsb pdb:6Y94|rcsb pdb:6Y95|reactome:R-HSA-9664323|go:"GO:0030234"(enzyme regulator activity)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0016032"(viral process)|rcsb pdb:6M7H|rcsb pdb:6UZZ|rcsb pdb:6V00|rcsb pdb:6V01|rcsb pdb:6PLM|rcsb pdb:6S5T|rcsb pdb:6SZ5|rcsb pdb:6XXF|rcsb pdb:6Y4O	refseq:NP_001027459.1|refseq:NP_068823.2|refseq:NP_071887.1|refseq:NP_954595.1|refseq:NP_954673.1|refseq:NP_001244322.1|refseq:NP_001244323.1|refseq:NP_001244325.1|ensembl:ENSG00000244687(gene)|ensembl:ENST00000371674(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006282"(regulation of DNA repair)|go:"GO:0006301"(postreplication repair)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0030154"(cell differentiation)|go:"GO:0031371"(ubiquitin conjugating enzyme complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035370"(UBC13-UEV1A complex)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070534"(protein K63-linked ubiquitination)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|rcsb pdb:2A4D|rcsb pdb:2C2V|rcsb pdb:2HLW|rcsb pdb:6D6I|reactome:R-HSA-168638|reactome:R-HSA-168927|reactome:R-HSA-202424|reactome:R-HSA-2871837|reactome:R-HSA-445989|reactome:R-HSA-450302|reactome:R-HSA-450321|reactome:R-HSA-5607764|reactome:R-HSA-9020702|reactome:R-HSA-937039|reactome:R-HSA-937041|reactome:R-HSA-9646399|reactome:R-HSA-975110|reactome:R-HSA-975144|reactome:R-HSA-983168|dip:DIP-41911N	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S2|caution:"UBE2N has been marked as the enzyme in this assay, although it is the UBE2N-UBE2V1 complex that has ubiquitinase (E3) activity. Neither UBE2N nor UBE2V1 have E2 or E3 activity on their own."|resulting-ptm:P62158 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:tTYcOd9bOh211njZVz7cYVybAMQ9606	rogid:x95N7Dj2KIqu5gySX59xLmfthUg9606	intact-crc:E077960F06C8BBAB|rigid:lONR7xDBi4X/LTeeaq35ZtrQs/c	false	-	his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P62158	uniprotkb:P22314	intact:EBI-397435|uniprotkb:P02593|uniprotkb:P70667|uniprotkb:P99014|uniprotkb:Q13942|uniprotkb:Q53S29|uniprotkb:Q61379|uniprotkb:Q61380|uniprotkb:Q96HK3|uniprotkb:P0DP25|uniprotkb:P0DP24|uniprotkb:P0DP23	intact:EBI-709688|uniprotkb:Q96E13|uniprotkb:Q5JRR8|ensembl:ENSP00000338413|ensembl:ENSP00000366568	psi-mi:calm_human(display_long)|uniprotkb:CALM1(gene name)|psi-mi:CALM1(display_short)|uniprotkb:CALM(gene name synonym)|uniprotkb:CAM(gene name synonym)|uniprotkb:CAM1(gene name synonym)|uniprotkb:CALM2(gene name)|psi-mi:CALM2(display_short)|uniprotkb:CAMB(gene name synonym)|uniprotkb:CALM3(gene name)|psi-mi:CALM3(display_short)|uniprotkb:CAM3(gene name synonym)|uniprotkb:CAMC(gene name synonym)|uniprotkb:CAMIII(gene name synonym)|uniprotkb:CAM2(gene name synonym)|uniprotkb:CALML2(gene name synonym)	psi-mi:uba1_human(display_long)|uniprotkb:Ubiquitin-activating enzyme E1(gene name synonym)|uniprotkb:Protein A1S9(gene name synonym)|uniprotkb:UBA1(gene name)|psi-mi:UBA1(display_short)|uniprotkb:A1S9T(gene name synonym)|uniprotkb:UBE1(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9970409|imex:IM-22822-24	author-confidence:Z-score = 4.27	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rcsb pdb:3SUI|rcsb pdb:2LGF|rcsb pdb:2LQC|rcsb pdb:2LQP|rcsb pdb:2Y4V|rcsb pdb:4JQ0|rcsb pdb:4LZX|rcsb pdb:4M1L|go:"GO:0010800"(positive regulation of peptidyl-threonine phosphorylation)|rcsb pdb:3J41|rcsb pdb:2LL6|go:"GO:0002027"(regulation of heart rate)|go:"GO:0005513"(detection of calcium ion)|go:"GO:0010881"(regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion)|go:"GO:0030017"(sarcomere)|go:"GO:0030801"(obsolete positive regulation of cyclic nucleotide metabolic process)|go:"GO:0032516"(positive regulation of phosphoprotein phosphatase activity)|go:"GO:0035307"(positive regulation of protein dephosphorylation)|go:"GO:0051343"(positive regulation of cyclic-nucleotide phosphodiesterase activity)|go:"GO:0072542"(protein phosphatase activator activity)|go:"GO:1901844"(regulation of cell communication by electrical coupling involved in cardiac conduction)|rcsb pdb:2LV6|rcsb pdb:2N6A|refseq:NP_001734.1|refseq:NP_005175.2|refseq:NP_008819.1|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|interpro:IPR002048(Calcium-binding EF-hand)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005876"(spindle microtubule)|go:"GO:0000922"(spindle pole)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005980"(glycogen catabolic process)|go:"GO:0006936"(muscle contraction)|go:"GO:0060315"(negative regulation of ryanodine-sensitive calcium-release channel activity)|go:"GO:0002576"(platelet degranulation)|go:"GO:0060316"(positive regulation of ryanodine-sensitive calcium-release channel activity)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0050999"(regulation of nitric-oxide synthase activity)|rcsb pdb:1AJI|rcsb pdb:1CDL|rcsb pdb:1CLL|rcsb pdb:1CTR|rcsb pdb:1IWQ|rcsb pdb:1J7O|rcsb pdb:1J7P|rcsb pdb:1K90|rcsb pdb:1K93|rcsb pdb:1L7Z|rcsb pdb:1LVC|rcsb pdb:1NKF|rcsb pdb:1PK0|rcsb pdb:1S26|rcsb pdb:1SK6|rcsb pdb:1SW8|rcsb pdb:1WRZ|rcsb pdb:1XFU|rcsb pdb:1XFV|rcsb pdb:1XFW|rcsb pdb:1XFX|rcsb pdb:1XFY|rcsb pdb:1XFZ|rcsb pdb:1Y6W|rcsb pdb:1YR5|rcsb pdb:1YRT|rcsb pdb:1YRU|rcsb pdb:1ZOT|rcsb pdb:1ZUZ|rcsb pdb:2BE6|rcsb pdb:2F3Y|rcsb pdb:2F3Z|rcsb pdb:2HF5|rcsb pdb:2I08|rcsb pdb:2JZI|rcsb pdb:2K0E|rcsb pdb:2K0F|rcsb pdb:2K0J|rcsb pdb:2K61|rcsb pdb:2KNE|rcsb pdb:2KUG|rcsb pdb:2KUH|rcsb pdb:2L53|rcsb pdb:2L7L|rcsb pdb:2R28|rcsb pdb:2V01|rcsb pdb:2V02|rcsb pdb:2VAY|rcsb pdb:2W73|rcsb pdb:2WEL|rcsb pdb:2X0G|rcsb pdb:3BYA|rcsb pdb:3DVE|rcsb pdb:3DVJ|rcsb pdb:3DVK|rcsb pdb:3DVM|rcsb pdb:3EWT|rcsb pdb:3EWV|rcsb pdb:3G43|rcsb pdb:3HR4|rcsb pdb:3O77|rcsb pdb:3O78|rcsb pdb:3OXQ|rcsb pdb:3UCT|rcsb pdb:3UCW|rcsb pdb:3UCY|rcsb pdb:4DCK|go:"GO:0010801"(negative regulation of peptidyl-threonine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031954"(positive regulation of protein autophosphorylation)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0000165"(MAPK cascade)|rcsb pdb:2M0J|rcsb pdb:2M0K|rcsb pdb:4UMO|rcsb pdb:4V0C|go:"GO:0031982"(vesicle)|rcsb pdb:4Q5U|rcsb pdb:4UPU|reactome:R-HSA-2672351|reactome:R-HSA-418359|reactome:R-HSA-425561|reactome:R-HSA-5576892|reactome:R-HSA-5578775|reactome:R-HSA-936837|refseq:NP_001292555.1|rcsb pdb:4OVN|rcsb pdb:5COC|go:"GO:0021762"(substantia nigra development)|go:"GO:0070062"(extracellular exosome)|rcsb pdb:4BW7|rcsb pdb:4BW8|rcsb pdb:4L79|rcsb pdb:5DBR|rcsb pdb:4DJC|rcsb pdb:2M55|rcsb pdb:2LL7|go:"GO:0019855"(calcium channel inhibitor activity)|go:"GO:0001975"(response to amphetamine)|go:"GO:0007190"(activation of adenylate cyclase activity)|go:"GO:0030235"(nitric-oxide synthase regulator activity)|go:"GO:0030426"(growth cone)|go:"GO:0051000"(positive regulation of nitric-oxide synthase activity)|go:"GO:0051412"(response to corticosterone)|go:"GO:1901841"(regulation of high voltage-gated calcium channel activity)|rcsb pdb:2N77|go:"GO:0032991"(protein-containing complex)|go:"GO:0006479"(protein methylation)|go:"GO:0014069"(postsynaptic density)|rcsb pdb:5DSU|reactome:R-HSA-8876725|rcsb pdb:4GOW|rcsb pdb:4Q57|go:"GO:0043647"(inositol phosphate metabolic process)|go:"GO:0022400"(regulation of rhodopsin mediated signaling pathway)|go:"GO:0038095"(Fc-epsilon receptor signaling pathway)|go:"GO:0005576"(extracellular region)|go:"GO:0005737"(cytoplasm)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0010880"(regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0031432"(titin binding)|go:"GO:0031996"(thioesterase binding)|go:"GO:0031997"(N-terminal myristoylation domain binding)|go:"GO:0043274"(phospholipase binding)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0051592"(response to calcium ion)|go:"GO:0055117"(regulation of cardiac muscle contraction)|rcsb pdb:2MG5|go:"GO:0005088"|go:"GO:0007223"(Wnt signaling pathway, calcium modulating pathway)|go:"GO:0008440"(inositol-1,4,5-trisphosphate 3-kinase activity)|go:"GO:0015276"(ligand-gated ion channel activity)|go:"GO:0005634"(nucleus)|rcsb pdb:4JPZ|ensembl:ENST00000272298|ensembl:ENST00000291295|ensembl:ENST00000356978|ensembl:ENST00000596362|refseq:NP_001292553.1|refseq:NP_001292554.1|rcsb pdb:4BYF|reactome:R-HSA-111932|reactome:R-HSA-111933|reactome:R-HSA-111957|reactome:R-HSA-111997|reactome:R-HSA-114608|reactome:R-HSA-1445148|reactome:R-HSA-1474151|reactome:R-HSA-180024|reactome:R-HSA-1855204|reactome:R-HSA-203615|reactome:R-HSA-2514859|reactome:R-HSA-2871809|reactome:R-HSA-4086398|reactome:R-HSA-442717|reactome:R-HSA-442729|reactome:R-HSA-442745|reactome:R-HSA-442982|reactome:R-HSA-445355|reactome:R-HSA-451308|reactome:R-HSA-5218920|reactome:R-HSA-5218921|reactome:R-HSA-5607763|reactome:R-HSA-5626467|reactome:R-HSA-5627123|reactome:R-HSA-5673001|reactome:R-HSA-70221|reactome:R-HSA-983695|ensembl:ENSG00000143933|ensembl:ENSG00000160014|ensembl:ENSG00000198668|ensembl:ENSP00000272298|ensembl:ENSP00000291295|ensembl:ENSP00000349467|ensembl:ENSP00000472141|rcsb pdb:5NIN|rcsb pdb:5VMS|rcsb pdb:5WSU|rcsb pdb:5WSV|rcsb pdb:6U39|rcsb pdb:6U3A|rcsb pdb:6U3B|rcsb pdb:6U3D|rcsb pdb:2N8J|rcsb pdb:5GGM|rcsb pdb:5J8H|reactome:R-HSA-163615|reactome:R-HSA-5210891|refseq:NP_001316851.1|refseq:NP_001316852.1|refseq:NP_001316853.1|refseq:NP_001316854.1|refseq:NP_001316855.1|rcsb pdb:2N27|rcsb pdb:5DOW|rcsb pdb:5I0I|rcsb pdb:5J03|rcsb pdb:5K7L|rcsb pdb:5K8Q|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0000086"(G2/M transition of mitotic cell cycle)|go:"GO:0043388"(positive regulation of DNA binding)|dip:DIP-31794N|rcsb pdb:1UP5|rcsb pdb:5JQA|rcsb pdb:5JTH|rcsb pdb:5OEO|rcsb pdb:5TP5|rcsb pdb:5TP6|rcsb pdb:5V02|rcsb pdb:5V03|rcsb pdb:5V7X|rcsb pdb:5WBX|rcsb pdb:5WC5|rcsb pdb:6B8L|rcsb pdb:6B8M|rcsb pdb:6B8N|rcsb pdb:6B8P|rcsb pdb:6B8Q|rcsb pdb:6C1D|rcsb pdb:6C1G|rcsb pdb:6C1H|rcsb pdb:6CNM|rcsb pdb:6CNN|rcsb pdb:6CNO|rcsb pdb:6FEG|rcsb pdb:6FEH|reactome:R-HSA-2025928|reactome:R-HSA-2151201|go:"GO:0034704"(calcium channel complex)|go:"GO:0010856"(adenylate cyclase activator activity)|go:"GO:0051186"(obsolete cofactor metabolic process)|go:"GO:0075206"(obsolete positive regulation by host of symbiont cAMP-mediated signal transduction)|go:"GO:0060314"(regulation of ryanodine-sensitive calcium-release channel activity)|interpro:IPR039030|go:"GO:1902494"(catalytic complex)|go:"GO:0043234"|go:"GO:0008179"(adenylate cyclase binding)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0030819"(obsolete positive regulation of cAMP biosynthetic process)|rcsb pdb:6BUT|rcsb pdb:6DAD|rcsb pdb:6DAE|rcsb pdb:6DAF|rcsb pdb:6DAH|rcsb pdb:6E2F|rcsb pdb:6E2G|rcsb pdb:6EEB|rcsb pdb:6GDK|rcsb pdb:6GDL|rcsb pdb:6HCS|rcsb pdb:6JI8|rcsb pdb:6JII|rcsb pdb:6JIU|rcsb pdb:6JIY|rcsb pdb:6JRS|rcsb pdb:6JV2|rcsb pdb:6K4K|rcsb pdb:6K4L|rcsb pdb:6K4R|rcsb pdb:6MUD|rcsb pdb:6MUE|rcsb pdb:6N5W|rcsb pdb:6O5G|reactome:R-HSA-438066|reactome:R-HSA-442720|reactome:R-HSA-5673000|reactome:R-HSA-6802946|reactome:R-HSA-6802949|reactome:R-HSA-6802952|reactome:R-HSA-6802955|reactome:R-HSA-9009391|reactome:R-HSA-9022535|reactome:R-HSA-9022692|reactome:R-HSA-9617324|reactome:R-HSA-9619229|reactome:R-HSA-9619483|reactome:R-HSA-9620244|go:"GO:0019722"(calcium-mediated signaling)|rcsb pdb:6PBX|rcsb pdb:6PBY|reactome:R-HSA-9649948|go:"GO:0005623"(obsolete cell)|rcsb pdb:6HR1|rcsb pdb:6OS4|rcsb pdb:6Y4P|rcsb pdb:6Y94|rcsb pdb:6Y95|reactome:R-HSA-9664323|go:"GO:0030234"(enzyme regulator activity)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0016032"(viral process)|rcsb pdb:6M7H|rcsb pdb:6UZZ|rcsb pdb:6V00|rcsb pdb:6V01|rcsb pdb:6PLM|rcsb pdb:6S5T|rcsb pdb:6SZ5|rcsb pdb:6XXF|rcsb pdb:6Y4O	refseq:NP_003325.2|refseq:NP_695012.1|refseq:XP_016885269.1|refseq:XP_016885270.1|dip:DIP-33686N|ensembl:ENSG00000130985(gene)|ensembl:ENST00000335972(transcript)|ensembl:ENST00000377351(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0004839"(ubiquitin activating enzyme activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0032446"(protein modification by small protein conjugation)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000011(Ubiquitin-activating enzyme, E1)|interpro:IPR000594(UBA/THIF-type NAD/FAD binding fold)|interpro:IPR018074|interpro:IPR018075|interpro:IPR018965|interpro:IPR019572|interpro:IPR032418|interpro:IPR032420|interpro:IPR033127|interpro:IPR035985|interpro:IPR038252|interpro:IPR042063|interpro:IPR042302|interpro:IPR042449|mint:P22314|rcsb pdb:4P22|rcsb pdb:6DC6|reactome:R-HSA-8866652|reactome:R-HSA-983168	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S2|caution:"UBE2N has been marked as the enzyme in this assay, although it is the UBE2N-UBE2V1 complex that has ubiquitinase (E3) activity. Neither UBE2N nor UBE2V1 have E2 or E3 activity on their own."|resulting-ptm:P62158 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:tTYcOd9bOh211njZVz7cYVybAMQ9606	rogid:q+vEeA0XLST0Zz173bmEt0dNbDE9606	intact-crc:E077960F06C8BBAB|rigid:lONR7xDBi4X/LTeeaq35ZtrQs/c	false	-	his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P62158	uniprotkb:P61088	intact:EBI-397435|uniprotkb:P02593|uniprotkb:P70667|uniprotkb:P99014|uniprotkb:Q13942|uniprotkb:Q53S29|uniprotkb:Q61379|uniprotkb:Q61380|uniprotkb:Q96HK3|uniprotkb:P0DP25|uniprotkb:P0DP24|uniprotkb:P0DP23	intact:EBI-1052908|uniprotkb:Q16781|uniprotkb:Q53Y81|ensembl:ENSP00000316176	psi-mi:calm_human(display_long)|uniprotkb:CALM1(gene name)|psi-mi:CALM1(display_short)|uniprotkb:CALM(gene name synonym)|uniprotkb:CAM(gene name synonym)|uniprotkb:CAM1(gene name synonym)|uniprotkb:CALM2(gene name)|psi-mi:CALM2(display_short)|uniprotkb:CAMB(gene name synonym)|uniprotkb:CALM3(gene name)|psi-mi:CALM3(display_short)|uniprotkb:CAM3(gene name synonym)|uniprotkb:CAMC(gene name synonym)|uniprotkb:CAMIII(gene name synonym)|uniprotkb:CAM2(gene name synonym)|uniprotkb:CALML2(gene name synonym)	psi-mi:ube2n_human(display_long)|uniprotkb:Ubiquitin-protein ligase N(gene name synonym)|uniprotkb:Ubiquitin carrier protein N(gene name synonym)|uniprotkb:Ubc13(gene name synonym)|uniprotkb:Bendless-like ubiquitin-conjugating enzyme(gene name synonym)|uniprotkb:UBE2N(gene name)|psi-mi:UBE2N(display_short)|uniprotkb:BLU(gene name synonym)|uniprotkb:UbcH13(gene name synonym)|uniprotkb:E2 ubiquitin-conjugating enzyme N(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9970409|imex:IM-22822-24	author-confidence:Z-score = 4.27	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rcsb pdb:3SUI|rcsb pdb:2LGF|rcsb pdb:2LQC|rcsb pdb:2LQP|rcsb pdb:2Y4V|rcsb pdb:4JQ0|rcsb pdb:4LZX|rcsb pdb:4M1L|go:"GO:0010800"(positive regulation of peptidyl-threonine phosphorylation)|rcsb pdb:3J41|rcsb pdb:2LL6|go:"GO:0002027"(regulation of heart rate)|go:"GO:0005513"(detection of calcium ion)|go:"GO:0010881"(regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion)|go:"GO:0030017"(sarcomere)|go:"GO:0030801"(obsolete positive regulation of cyclic nucleotide metabolic process)|go:"GO:0032516"(positive regulation of phosphoprotein phosphatase activity)|go:"GO:0035307"(positive regulation of protein dephosphorylation)|go:"GO:0051343"(positive regulation of cyclic-nucleotide phosphodiesterase activity)|go:"GO:0072542"(protein phosphatase activator activity)|go:"GO:1901844"(regulation of cell communication by electrical coupling involved in cardiac conduction)|rcsb pdb:2LV6|rcsb pdb:2N6A|refseq:NP_001734.1|refseq:NP_005175.2|refseq:NP_008819.1|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|interpro:IPR002048(Calcium-binding EF-hand)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005876"(spindle microtubule)|go:"GO:0000922"(spindle pole)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005980"(glycogen catabolic process)|go:"GO:0006936"(muscle contraction)|go:"GO:0060315"(negative regulation of ryanodine-sensitive calcium-release channel activity)|go:"GO:0002576"(platelet degranulation)|go:"GO:0060316"(positive regulation of ryanodine-sensitive calcium-release channel activity)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0050999"(regulation of nitric-oxide synthase activity)|rcsb pdb:1AJI|rcsb pdb:1CDL|rcsb pdb:1CLL|rcsb pdb:1CTR|rcsb pdb:1IWQ|rcsb pdb:1J7O|rcsb pdb:1J7P|rcsb pdb:1K90|rcsb pdb:1K93|rcsb pdb:1L7Z|rcsb pdb:1LVC|rcsb pdb:1NKF|rcsb pdb:1PK0|rcsb pdb:1S26|rcsb pdb:1SK6|rcsb pdb:1SW8|rcsb pdb:1WRZ|rcsb pdb:1XFU|rcsb pdb:1XFV|rcsb pdb:1XFW|rcsb pdb:1XFX|rcsb pdb:1XFY|rcsb pdb:1XFZ|rcsb pdb:1Y6W|rcsb pdb:1YR5|rcsb pdb:1YRT|rcsb pdb:1YRU|rcsb pdb:1ZOT|rcsb pdb:1ZUZ|rcsb pdb:2BE6|rcsb pdb:2F3Y|rcsb pdb:2F3Z|rcsb pdb:2HF5|rcsb pdb:2I08|rcsb pdb:2JZI|rcsb pdb:2K0E|rcsb pdb:2K0F|rcsb pdb:2K0J|rcsb pdb:2K61|rcsb pdb:2KNE|rcsb pdb:2KUG|rcsb pdb:2KUH|rcsb pdb:2L53|rcsb pdb:2L7L|rcsb pdb:2R28|rcsb pdb:2V01|rcsb pdb:2V02|rcsb pdb:2VAY|rcsb pdb:2W73|rcsb pdb:2WEL|rcsb pdb:2X0G|rcsb pdb:3BYA|rcsb pdb:3DVE|rcsb pdb:3DVJ|rcsb pdb:3DVK|rcsb pdb:3DVM|rcsb pdb:3EWT|rcsb pdb:3EWV|rcsb pdb:3G43|rcsb pdb:3HR4|rcsb pdb:3O77|rcsb pdb:3O78|rcsb pdb:3OXQ|rcsb pdb:3UCT|rcsb pdb:3UCW|rcsb pdb:3UCY|rcsb pdb:4DCK|go:"GO:0010801"(negative regulation of peptidyl-threonine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031954"(positive regulation of protein autophosphorylation)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0000165"(MAPK cascade)|rcsb pdb:2M0J|rcsb pdb:2M0K|rcsb pdb:4UMO|rcsb pdb:4V0C|go:"GO:0031982"(vesicle)|rcsb pdb:4Q5U|rcsb pdb:4UPU|reactome:R-HSA-2672351|reactome:R-HSA-418359|reactome:R-HSA-425561|reactome:R-HSA-5576892|reactome:R-HSA-5578775|reactome:R-HSA-936837|refseq:NP_001292555.1|rcsb pdb:4OVN|rcsb pdb:5COC|go:"GO:0021762"(substantia nigra development)|go:"GO:0070062"(extracellular exosome)|rcsb pdb:4BW7|rcsb pdb:4BW8|rcsb pdb:4L79|rcsb pdb:5DBR|rcsb pdb:4DJC|rcsb pdb:2M55|rcsb pdb:2LL7|go:"GO:0019855"(calcium channel inhibitor activity)|go:"GO:0001975"(response to amphetamine)|go:"GO:0007190"(activation of adenylate cyclase activity)|go:"GO:0030235"(nitric-oxide synthase regulator activity)|go:"GO:0030426"(growth cone)|go:"GO:0051000"(positive regulation of nitric-oxide synthase activity)|go:"GO:0051412"(response to corticosterone)|go:"GO:1901841"(regulation of high voltage-gated calcium channel activity)|rcsb pdb:2N77|go:"GO:0032991"(protein-containing complex)|go:"GO:0006479"(protein methylation)|go:"GO:0014069"(postsynaptic density)|rcsb pdb:5DSU|reactome:R-HSA-8876725|rcsb pdb:4GOW|rcsb pdb:4Q57|go:"GO:0043647"(inositol phosphate metabolic process)|go:"GO:0022400"(regulation of rhodopsin mediated signaling pathway)|go:"GO:0038095"(Fc-epsilon receptor signaling pathway)|go:"GO:0005576"(extracellular region)|go:"GO:0005737"(cytoplasm)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0010880"(regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0031432"(titin binding)|go:"GO:0031996"(thioesterase binding)|go:"GO:0031997"(N-terminal myristoylation domain binding)|go:"GO:0043274"(phospholipase binding)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0051592"(response to calcium ion)|go:"GO:0055117"(regulation of cardiac muscle contraction)|rcsb pdb:2MG5|go:"GO:0005088"|go:"GO:0007223"(Wnt signaling pathway, calcium modulating pathway)|go:"GO:0008440"(inositol-1,4,5-trisphosphate 3-kinase activity)|go:"GO:0015276"(ligand-gated ion channel activity)|go:"GO:0005634"(nucleus)|rcsb pdb:4JPZ|ensembl:ENST00000272298|ensembl:ENST00000291295|ensembl:ENST00000356978|ensembl:ENST00000596362|refseq:NP_001292553.1|refseq:NP_001292554.1|rcsb pdb:4BYF|reactome:R-HSA-111932|reactome:R-HSA-111933|reactome:R-HSA-111957|reactome:R-HSA-111997|reactome:R-HSA-114608|reactome:R-HSA-1445148|reactome:R-HSA-1474151|reactome:R-HSA-180024|reactome:R-HSA-1855204|reactome:R-HSA-203615|reactome:R-HSA-2514859|reactome:R-HSA-2871809|reactome:R-HSA-4086398|reactome:R-HSA-442717|reactome:R-HSA-442729|reactome:R-HSA-442745|reactome:R-HSA-442982|reactome:R-HSA-445355|reactome:R-HSA-451308|reactome:R-HSA-5218920|reactome:R-HSA-5218921|reactome:R-HSA-5607763|reactome:R-HSA-5626467|reactome:R-HSA-5627123|reactome:R-HSA-5673001|reactome:R-HSA-70221|reactome:R-HSA-983695|ensembl:ENSG00000143933|ensembl:ENSG00000160014|ensembl:ENSG00000198668|ensembl:ENSP00000272298|ensembl:ENSP00000291295|ensembl:ENSP00000349467|ensembl:ENSP00000472141|rcsb pdb:5NIN|rcsb pdb:5VMS|rcsb pdb:5WSU|rcsb pdb:5WSV|rcsb pdb:6U39|rcsb pdb:6U3A|rcsb pdb:6U3B|rcsb pdb:6U3D|rcsb pdb:2N8J|rcsb pdb:5GGM|rcsb pdb:5J8H|reactome:R-HSA-163615|reactome:R-HSA-5210891|refseq:NP_001316851.1|refseq:NP_001316852.1|refseq:NP_001316853.1|refseq:NP_001316854.1|refseq:NP_001316855.1|rcsb pdb:2N27|rcsb pdb:5DOW|rcsb pdb:5I0I|rcsb pdb:5J03|rcsb pdb:5K7L|rcsb pdb:5K8Q|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0000086"(G2/M transition of mitotic cell cycle)|go:"GO:0043388"(positive regulation of DNA binding)|dip:DIP-31794N|rcsb pdb:1UP5|rcsb pdb:5JQA|rcsb pdb:5JTH|rcsb pdb:5OEO|rcsb pdb:5TP5|rcsb pdb:5TP6|rcsb pdb:5V02|rcsb pdb:5V03|rcsb pdb:5V7X|rcsb pdb:5WBX|rcsb pdb:5WC5|rcsb pdb:6B8L|rcsb pdb:6B8M|rcsb pdb:6B8N|rcsb pdb:6B8P|rcsb pdb:6B8Q|rcsb pdb:6C1D|rcsb pdb:6C1G|rcsb pdb:6C1H|rcsb pdb:6CNM|rcsb pdb:6CNN|rcsb pdb:6CNO|rcsb pdb:6FEG|rcsb pdb:6FEH|reactome:R-HSA-2025928|reactome:R-HSA-2151201|go:"GO:0034704"(calcium channel complex)|go:"GO:0010856"(adenylate cyclase activator activity)|go:"GO:0051186"(obsolete cofactor metabolic process)|go:"GO:0075206"(obsolete positive regulation by host of symbiont cAMP-mediated signal transduction)|go:"GO:0060314"(regulation of ryanodine-sensitive calcium-release channel activity)|interpro:IPR039030|go:"GO:1902494"(catalytic complex)|go:"GO:0043234"|go:"GO:0008179"(adenylate cyclase binding)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0030819"(obsolete positive regulation of cAMP biosynthetic process)|rcsb pdb:6BUT|rcsb pdb:6DAD|rcsb pdb:6DAE|rcsb pdb:6DAF|rcsb pdb:6DAH|rcsb pdb:6E2F|rcsb pdb:6E2G|rcsb pdb:6EEB|rcsb pdb:6GDK|rcsb pdb:6GDL|rcsb pdb:6HCS|rcsb pdb:6JI8|rcsb pdb:6JII|rcsb pdb:6JIU|rcsb pdb:6JIY|rcsb pdb:6JRS|rcsb pdb:6JV2|rcsb pdb:6K4K|rcsb pdb:6K4L|rcsb pdb:6K4R|rcsb pdb:6MUD|rcsb pdb:6MUE|rcsb pdb:6N5W|rcsb pdb:6O5G|reactome:R-HSA-438066|reactome:R-HSA-442720|reactome:R-HSA-5673000|reactome:R-HSA-6802946|reactome:R-HSA-6802949|reactome:R-HSA-6802952|reactome:R-HSA-6802955|reactome:R-HSA-9009391|reactome:R-HSA-9022535|reactome:R-HSA-9022692|reactome:R-HSA-9617324|reactome:R-HSA-9619229|reactome:R-HSA-9619483|reactome:R-HSA-9620244|go:"GO:0019722"(calcium-mediated signaling)|rcsb pdb:6PBX|rcsb pdb:6PBY|reactome:R-HSA-9649948|go:"GO:0005623"(obsolete cell)|rcsb pdb:6HR1|rcsb pdb:6OS4|rcsb pdb:6Y4P|rcsb pdb:6Y94|rcsb pdb:6Y95|reactome:R-HSA-9664323|go:"GO:0030234"(enzyme regulator activity)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0016032"(viral process)|rcsb pdb:6M7H|rcsb pdb:6UZZ|rcsb pdb:6V00|rcsb pdb:6V01|rcsb pdb:6PLM|rcsb pdb:6S5T|rcsb pdb:6SZ5|rcsb pdb:6XXF|rcsb pdb:6Y4O	refseq:NP_003339.1|dip:DIP-29829N|ensembl:ENSG00000177889(gene)|ensembl:ENST00000318066(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000729"(DNA double-strand break processing)|go:"GO:0001650"(fibrillar center)|go:"GO:0003723"(RNA binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006282"(regulation of DNA repair)|go:"GO:0006301"(postreplication repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016574"(histone ubiquitination)|go:"GO:0031058"(positive regulation of histone modification)|go:"GO:0031372"(UBC13-MMS2 complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033182"(regulation of histone ubiquitination)|go:"GO:0035370"(UBC13-UEV1A complex)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0061631"(ubiquitin conjugating enzyme activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070534"(protein K63-linked ubiquitination)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|interpro:IPR023313|rcsb pdb:1J7D|rcsb pdb:2C2V|rcsb pdb:3HCT|rcsb pdb:3HCU|rcsb pdb:3VON|rcsb pdb:3W31|rcsb pdb:4DHI|rcsb pdb:4DHJ|rcsb pdb:4DHZ|rcsb pdb:4IP3|rcsb pdb:4NR3|rcsb pdb:4NRG|rcsb pdb:4NRI|rcsb pdb:4ONL|rcsb pdb:4ONM|rcsb pdb:4ONN|rcsb pdb:4ORH|rcsb pdb:4TKP|rcsb pdb:4WHV|rcsb pdb:5AIT|rcsb pdb:5AIU|rcsb pdb:5EYA|rcsb pdb:5H7S|rcsb pdb:5VNZ|rcsb pdb:5VO0|rcsb pdb:5YWR|rcsb pdb:6D6I|rcsb pdb:6JKY|rcsb pdb:6KFP|rcsb pdb:6KG6|rcsb pdb:6KL4|rcsb pdb:6LP2|rcsb pdb:6P5B|rcsb pdb:6S53|reactome:R-HSA-168927|reactome:R-HSA-202424|reactome:R-HSA-2871837|reactome:R-HSA-445989|reactome:R-HSA-450302|reactome:R-HSA-450321|reactome:R-HSA-5607764|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-5696395|reactome:R-HSA-69473|reactome:R-HSA-8866654|reactome:R-HSA-9020702|reactome:R-HSA-937039|reactome:R-HSA-937041|reactome:R-HSA-9646399|reactome:R-HSA-975110|reactome:R-HSA-975144|reactome:R-HSA-983168|rcsb pdb:6ULH|rcsb pdb:6UMP|rcsb pdb:6UMS|rcsb pdb:7BBD|rcsb pdb:7BBF|rcsb pdb:7BXG|reactome:R-HSA-1169408|reactome:R-HSA-168638	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S2|caution:"UBE2N has been marked as the enzyme in this assay, although it is the UBE2N-UBE2V1 complex that has ubiquitinase (E3) activity. Neither UBE2N nor UBE2V1 have E2 or E3 activity on their own."|resulting-ptm:P62158 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:tTYcOd9bOh211njZVz7cYVybAMQ9606	rogid:dqdszHlq5FLPHC6UWX6uvkC6Yz89606	intact-crc:E077960F06C8BBAB|rigid:lONR7xDBi4X/LTeeaq35ZtrQs/c	false	-	his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q13404	uniprotkb:P22314	intact:EBI-1050671|uniprotkb:Q13403|uniprotkb:Q13532|uniprotkb:Q96H34|uniprotkb:Q9GZT0|uniprotkb:Q9GZW1|uniprotkb:Q9H4J3|uniprotkb:Q9H4J4|uniprotkb:Q9UKL1|uniprotkb:Q9UM48|uniprotkb:Q9UM49|uniprotkb:Q9UM50|uniprotkb:Q5TGE3|uniprotkb:E1P629|uniprotkb:Q5TGE0|ensembl:ENSP00000360739	intact:EBI-709688|uniprotkb:Q96E13|uniprotkb:Q5JRR8|ensembl:ENSP00000338413|ensembl:ENSP00000366568	psi-mi:ub2v1_human(display_long)|uniprotkb:CROC-1(gene name synonym)|uniprotkb:TRAF6-regulated IKK activator 1 beta Uev1A(gene name synonym)|uniprotkb:P/OKcl.19(orf name)|uniprotkb:UBE2V1(gene name)|psi-mi:UBE2V1(display_short)|uniprotkb:CROC1(gene name synonym)|uniprotkb:UBE2V(gene name synonym)|uniprotkb:UEV1(gene name synonym)	psi-mi:uba1_human(display_long)|uniprotkb:Ubiquitin-activating enzyme E1(gene name synonym)|uniprotkb:Protein A1S9(gene name synonym)|uniprotkb:UBA1(gene name)|psi-mi:UBA1(display_short)|uniprotkb:A1S9T(gene name synonym)|uniprotkb:UBE1(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9970430|imex:IM-22822-25	author-confidence:Z-score = 4.65	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001027459.1|refseq:NP_068823.2|refseq:NP_071887.1|refseq:NP_954595.1|refseq:NP_954673.1|refseq:NP_001244322.1|refseq:NP_001244323.1|refseq:NP_001244325.1|ensembl:ENSG00000244687(gene)|ensembl:ENST00000371674(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006282"(regulation of DNA repair)|go:"GO:0006301"(postreplication repair)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0030154"(cell differentiation)|go:"GO:0031371"(ubiquitin conjugating enzyme complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035370"(UBC13-UEV1A complex)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070534"(protein K63-linked ubiquitination)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|rcsb pdb:2A4D|rcsb pdb:2C2V|rcsb pdb:2HLW|rcsb pdb:6D6I|reactome:R-HSA-168638|reactome:R-HSA-168927|reactome:R-HSA-202424|reactome:R-HSA-2871837|reactome:R-HSA-445989|reactome:R-HSA-450302|reactome:R-HSA-450321|reactome:R-HSA-5607764|reactome:R-HSA-9020702|reactome:R-HSA-937039|reactome:R-HSA-937041|reactome:R-HSA-9646399|reactome:R-HSA-975110|reactome:R-HSA-975144|reactome:R-HSA-983168|dip:DIP-41911N	refseq:NP_003325.2|refseq:NP_695012.1|refseq:XP_016885269.1|refseq:XP_016885270.1|dip:DIP-33686N|ensembl:ENSG00000130985(gene)|ensembl:ENST00000335972(transcript)|ensembl:ENST00000377351(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0004839"(ubiquitin activating enzyme activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0032446"(protein modification by small protein conjugation)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000011(Ubiquitin-activating enzyme, E1)|interpro:IPR000594(UBA/THIF-type NAD/FAD binding fold)|interpro:IPR018074|interpro:IPR018075|interpro:IPR018965|interpro:IPR019572|interpro:IPR032418|interpro:IPR032420|interpro:IPR033127|interpro:IPR035985|interpro:IPR038252|interpro:IPR042063|interpro:IPR042302|interpro:IPR042449|mint:P22314|rcsb pdb:4P22|rcsb pdb:6DC6|reactome:R-HSA-8866652|reactome:R-HSA-983168	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S2|caution:"UBE2N has been marked as the enzyme in this assay, although it is the UBE2N-UBE2V1 complex that has ubiquitinase (E3) activity. Neither UBE2N nor UBE2V1 have E2 or E3 activity on their own."|resulting-ptm:P63148 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:x95N7Dj2KIqu5gySX59xLmfthUg9606	rogid:q+vEeA0XLST0Zz173bmEt0dNbDE9606	intact-crc:75D607913356A6F4|rigid:yvrN+6KGRqz1KytlKoR31fDamXA	false	his tag:?-?	his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q13404	uniprotkb:P63148	intact:EBI-1050671|uniprotkb:Q13403|uniprotkb:Q13532|uniprotkb:Q96H34|uniprotkb:Q9GZT0|uniprotkb:Q9GZW1|uniprotkb:Q9H4J3|uniprotkb:Q9H4J4|uniprotkb:Q9UKL1|uniprotkb:Q9UM48|uniprotkb:Q9UM49|uniprotkb:Q9UM50|uniprotkb:Q5TGE3|uniprotkb:E1P629|uniprotkb:Q5TGE0|ensembl:ENSP00000360739	intact:EBI-9916016|uniprotkb:Q9D0J6|uniprotkb:P23567|ensembl:ENSOCUP00000013548	psi-mi:ub2v1_human(display_long)|uniprotkb:CROC-1(gene name synonym)|uniprotkb:TRAF6-regulated IKK activator 1 beta Uev1A(gene name synonym)|uniprotkb:P/OKcl.19(orf name)|uniprotkb:UBE2V1(gene name)|psi-mi:UBE2V1(display_short)|uniprotkb:CROC1(gene name synonym)|uniprotkb:UBE2V(gene name synonym)|uniprotkb:UEV1(gene name synonym)	psi-mi:ube2b_rabit(display_long)|uniprotkb:RAD6 homolog B(gene name synonym)|uniprotkb:RAD6B(gene name synonym)|uniprotkb:Ubiquitin carrier protein B(gene name synonym)|uniprotkb:"Ubiquitin-conjugating enzyme E2(14k)"(gene name synonym)|uniprotkb:Ubiquitin-protein ligase B(gene name synonym)|uniprotkb:UBE2B(gene name)|psi-mi:UBE2B(display_short)|uniprotkb:E2 ubiquitin-conjugating enzyme B(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9986(rabit)|taxid:9986("Oryctolagus cuniculus (Rabbit)")	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9970430|imex:IM-22822-25	author-confidence:Z-score = 4.65	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001027459.1|refseq:NP_068823.2|refseq:NP_071887.1|refseq:NP_954595.1|refseq:NP_954673.1|refseq:NP_001244322.1|refseq:NP_001244323.1|refseq:NP_001244325.1|ensembl:ENSG00000244687(gene)|ensembl:ENST00000371674(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006282"(regulation of DNA repair)|go:"GO:0006301"(postreplication repair)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0030154"(cell differentiation)|go:"GO:0031371"(ubiquitin conjugating enzyme complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035370"(UBC13-UEV1A complex)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070534"(protein K63-linked ubiquitination)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|rcsb pdb:2A4D|rcsb pdb:2C2V|rcsb pdb:2HLW|rcsb pdb:6D6I|reactome:R-HSA-168638|reactome:R-HSA-168927|reactome:R-HSA-202424|reactome:R-HSA-2871837|reactome:R-HSA-445989|reactome:R-HSA-450302|reactome:R-HSA-450321|reactome:R-HSA-5607764|reactome:R-HSA-9020702|reactome:R-HSA-937039|reactome:R-HSA-937041|reactome:R-HSA-9646399|reactome:R-HSA-975110|reactome:R-HSA-975144|reactome:R-HSA-983168|dip:DIP-41911N	refseq:NP_001075765.1|ensembl:ENSOCUG00000015774(gene)|ensembl:ENSOCUT00000015769(transcript)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005886"(plasma membrane)|go:"GO:0006281"(DNA repair)|go:"GO:0033503"(HULC complex)|go:"GO:0061631"(ubiquitin conjugating enzyme activity)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0070936"(protein K48-linked ubiquitination)|go:"GO:0070979"(protein K11-linked ubiquitination)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|interpro:IPR023313	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S2|caution:"UBE2N has been marked as the enzyme in this assay, although it is the UBE2N-UBE2V1 complex that has ubiquitinase (E3) activity. Neither UBE2N nor UBE2V1 have E2 or E3 activity on their own."|resulting-ptm:P63148 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:x95N7Dj2KIqu5gySX59xLmfthUg9606	rogid:JvcUPH+3qQXicPsIRFnW19NOc3c9986	intact-crc:75D607913356A6F4|rigid:yvrN+6KGRqz1KytlKoR31fDamXA	false	his tag:?-?	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q13404	uniprotkb:P61088	intact:EBI-1050671|uniprotkb:Q13403|uniprotkb:Q13532|uniprotkb:Q96H34|uniprotkb:Q9GZT0|uniprotkb:Q9GZW1|uniprotkb:Q9H4J3|uniprotkb:Q9H4J4|uniprotkb:Q9UKL1|uniprotkb:Q9UM48|uniprotkb:Q9UM49|uniprotkb:Q9UM50|uniprotkb:Q5TGE3|uniprotkb:E1P629|uniprotkb:Q5TGE0|ensembl:ENSP00000360739	intact:EBI-1052908|uniprotkb:Q16781|uniprotkb:Q53Y81|ensembl:ENSP00000316176	psi-mi:ub2v1_human(display_long)|uniprotkb:CROC-1(gene name synonym)|uniprotkb:TRAF6-regulated IKK activator 1 beta Uev1A(gene name synonym)|uniprotkb:P/OKcl.19(orf name)|uniprotkb:UBE2V1(gene name)|psi-mi:UBE2V1(display_short)|uniprotkb:CROC1(gene name synonym)|uniprotkb:UBE2V(gene name synonym)|uniprotkb:UEV1(gene name synonym)	psi-mi:ube2n_human(display_long)|uniprotkb:Ubiquitin-protein ligase N(gene name synonym)|uniprotkb:Ubiquitin carrier protein N(gene name synonym)|uniprotkb:Ubc13(gene name synonym)|uniprotkb:Bendless-like ubiquitin-conjugating enzyme(gene name synonym)|uniprotkb:UBE2N(gene name)|psi-mi:UBE2N(display_short)|uniprotkb:BLU(gene name synonym)|uniprotkb:UbcH13(gene name synonym)|uniprotkb:E2 ubiquitin-conjugating enzyme N(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9970430|imex:IM-22822-25	author-confidence:Z-score = 4.65	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001027459.1|refseq:NP_068823.2|refseq:NP_071887.1|refseq:NP_954595.1|refseq:NP_954673.1|refseq:NP_001244322.1|refseq:NP_001244323.1|refseq:NP_001244325.1|ensembl:ENSG00000244687(gene)|ensembl:ENST00000371674(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006282"(regulation of DNA repair)|go:"GO:0006301"(postreplication repair)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0030154"(cell differentiation)|go:"GO:0031371"(ubiquitin conjugating enzyme complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035370"(UBC13-UEV1A complex)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070534"(protein K63-linked ubiquitination)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|rcsb pdb:2A4D|rcsb pdb:2C2V|rcsb pdb:2HLW|rcsb pdb:6D6I|reactome:R-HSA-168638|reactome:R-HSA-168927|reactome:R-HSA-202424|reactome:R-HSA-2871837|reactome:R-HSA-445989|reactome:R-HSA-450302|reactome:R-HSA-450321|reactome:R-HSA-5607764|reactome:R-HSA-9020702|reactome:R-HSA-937039|reactome:R-HSA-937041|reactome:R-HSA-9646399|reactome:R-HSA-975110|reactome:R-HSA-975144|reactome:R-HSA-983168|dip:DIP-41911N	refseq:NP_003339.1|dip:DIP-29829N|ensembl:ENSG00000177889(gene)|ensembl:ENST00000318066(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000729"(DNA double-strand break processing)|go:"GO:0001650"(fibrillar center)|go:"GO:0003723"(RNA binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006282"(regulation of DNA repair)|go:"GO:0006301"(postreplication repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016574"(histone ubiquitination)|go:"GO:0031058"(positive regulation of histone modification)|go:"GO:0031372"(UBC13-MMS2 complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033182"(regulation of histone ubiquitination)|go:"GO:0035370"(UBC13-UEV1A complex)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0061631"(ubiquitin conjugating enzyme activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070534"(protein K63-linked ubiquitination)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|interpro:IPR023313|rcsb pdb:1J7D|rcsb pdb:2C2V|rcsb pdb:3HCT|rcsb pdb:3HCU|rcsb pdb:3VON|rcsb pdb:3W31|rcsb pdb:4DHI|rcsb pdb:4DHJ|rcsb pdb:4DHZ|rcsb pdb:4IP3|rcsb pdb:4NR3|rcsb pdb:4NRG|rcsb pdb:4NRI|rcsb pdb:4ONL|rcsb pdb:4ONM|rcsb pdb:4ONN|rcsb pdb:4ORH|rcsb pdb:4TKP|rcsb pdb:4WHV|rcsb pdb:5AIT|rcsb pdb:5AIU|rcsb pdb:5EYA|rcsb pdb:5H7S|rcsb pdb:5VNZ|rcsb pdb:5VO0|rcsb pdb:5YWR|rcsb pdb:6D6I|rcsb pdb:6JKY|rcsb pdb:6KFP|rcsb pdb:6KG6|rcsb pdb:6KL4|rcsb pdb:6LP2|rcsb pdb:6P5B|rcsb pdb:6S53|reactome:R-HSA-168927|reactome:R-HSA-202424|reactome:R-HSA-2871837|reactome:R-HSA-445989|reactome:R-HSA-450302|reactome:R-HSA-450321|reactome:R-HSA-5607764|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-5696395|reactome:R-HSA-69473|reactome:R-HSA-8866654|reactome:R-HSA-9020702|reactome:R-HSA-937039|reactome:R-HSA-937041|reactome:R-HSA-9646399|reactome:R-HSA-975110|reactome:R-HSA-975144|reactome:R-HSA-983168|rcsb pdb:6ULH|rcsb pdb:6UMP|rcsb pdb:6UMS|rcsb pdb:7BBD|rcsb pdb:7BBF|rcsb pdb:7BXG|reactome:R-HSA-1169408|reactome:R-HSA-168638	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S2|caution:"UBE2N has been marked as the enzyme in this assay, although it is the UBE2N-UBE2V1 complex that has ubiquitinase (E3) activity. Neither UBE2N nor UBE2V1 have E2 or E3 activity on their own."|resulting-ptm:P63148 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:x95N7Dj2KIqu5gySX59xLmfthUg9606	rogid:dqdszHlq5FLPHC6UWX6uvkC6Yz89606	intact-crc:75D607913356A6F4|rigid:yvrN+6KGRqz1KytlKoR31fDamXA	false	his tag:?-?	his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P78317	uniprotkb:Q13404	intact:EBI-2340927|uniprotkb:Q49AR8|uniprotkb:B2R6D6|uniprotkb:D6RF58|intact:EBI-28970119|ensembl:ENSP00000315212|ensembl:ENSP00000424076|ensembl:ENSP00000426503	intact:EBI-1050671|uniprotkb:Q13403|uniprotkb:Q13532|uniprotkb:Q96H34|uniprotkb:Q9GZT0|uniprotkb:Q9GZW1|uniprotkb:Q9H4J3|uniprotkb:Q9H4J4|uniprotkb:Q9UKL1|uniprotkb:Q9UM48|uniprotkb:Q9UM49|uniprotkb:Q9UM50|uniprotkb:Q5TGE3|uniprotkb:E1P629|uniprotkb:Q5TGE0|ensembl:ENSP00000360739	psi-mi:rnf4_human(display_long)|uniprotkb:SNURF(gene name synonym)|uniprotkb:RING finger protein 4(gene name synonym)|uniprotkb:Small nuclear ring finger protein(gene name synonym)|uniprotkb:RNF4(gene name)|psi-mi:RNF4(display_short)|uniprotkb:RES4-26(orf name)|uniprotkb:RING-type E3 ubiquitin transferase RNF4(gene name synonym)	psi-mi:ub2v1_human(display_long)|uniprotkb:CROC-1(gene name synonym)|uniprotkb:TRAF6-regulated IKK activator 1 beta Uev1A(gene name synonym)|uniprotkb:P/OKcl.19(orf name)|uniprotkb:UBE2V1(gene name)|psi-mi:UBE2V1(display_short)|uniprotkb:CROC1(gene name synonym)|uniprotkb:UBE2V(gene name synonym)|uniprotkb:UEV1(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9970451|imex:IM-22822-26	author-confidence:Z-score = 18.70	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001171938.1|refseq:NP_001171939.1|refseq:NP_002929.1|ensembl:ENSP00000315212|ensembl:ENSP00000424076|ensembl:ENSP00000426503|ensembl:ENST00000511859|ensembl:ENSP00000426615|ensembl:ENST00000541204|ensembl:ENSP00000446369|ensembl:ENSG00000063978(gene)|ensembl:ENST00000314289(transcript)|ensembl:ENST00000506706(transcript)|ensembl:ENST00000511600(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016604"(nuclear body)|go:"GO:0016605"(PML body)|go:"GO:0030374"(nuclear receptor coactivator activity)|go:"GO:0031491"(nucleosome binding)|go:"GO:0032184"(SUMO polymer binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046685"(response to arsenic-containing substance)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0070936"(protein K48-linked ubiquitination)|go:"GO:0070979"(protein K11-linked ubiquitination)|go:"GO:0085020"(protein K6-linked ubiquitination)|go:"GO:0090169"(regulation of spindle assembly)|go:"GO:0090234"(regulation of kinetochore assembly)|go:"GO:1990752"(microtubule end)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR043295|mint:P78317|rcsb pdb:2EA6|rcsb pdb:2XEU|rcsb pdb:4PPE|reactome:R-HSA-5693607|reactome:R-HSA-983168	refseq:NP_001027459.1|refseq:NP_068823.2|refseq:NP_071887.1|refseq:NP_954595.1|refseq:NP_954673.1|refseq:NP_001244322.1|refseq:NP_001244323.1|refseq:NP_001244325.1|ensembl:ENSG00000244687(gene)|ensembl:ENST00000371674(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006282"(regulation of DNA repair)|go:"GO:0006301"(postreplication repair)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0030154"(cell differentiation)|go:"GO:0031371"(ubiquitin conjugating enzyme complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035370"(UBC13-UEV1A complex)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070534"(protein K63-linked ubiquitination)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|rcsb pdb:2A4D|rcsb pdb:2C2V|rcsb pdb:2HLW|rcsb pdb:6D6I|reactome:R-HSA-168638|reactome:R-HSA-168927|reactome:R-HSA-202424|reactome:R-HSA-2871837|reactome:R-HSA-445989|reactome:R-HSA-450302|reactome:R-HSA-450321|reactome:R-HSA-5607764|reactome:R-HSA-9020702|reactome:R-HSA-937039|reactome:R-HSA-937041|reactome:R-HSA-9646399|reactome:R-HSA-975110|reactome:R-HSA-975144|reactome:R-HSA-983168|dip:DIP-41911N	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S2|caution:"UBE2N has been marked as the enzyme in this assay, although it is the UBE2N-UBE2V1 complex that has ubiquitinase (E3) activity. Neither UBE2N nor UBE2V1 have E2 or E3 activity on their own."|resulting-ptm:P78317 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:Yhu2iAaNQYcfGdYohDPBdhMFEpc9606	rogid:x95N7Dj2KIqu5gySX59xLmfthUg9606	intact-crc:199989D4D7E41A19|rigid:L470Pa3v+EQZh4y2zEIDFbHP/Ys	false	-	his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P78317	uniprotkb:P22314	intact:EBI-2340927|uniprotkb:Q49AR8|uniprotkb:B2R6D6|uniprotkb:D6RF58|intact:EBI-28970119|ensembl:ENSP00000315212|ensembl:ENSP00000424076|ensembl:ENSP00000426503	intact:EBI-709688|uniprotkb:Q96E13|uniprotkb:Q5JRR8|ensembl:ENSP00000338413|ensembl:ENSP00000366568	psi-mi:rnf4_human(display_long)|uniprotkb:SNURF(gene name synonym)|uniprotkb:RING finger protein 4(gene name synonym)|uniprotkb:Small nuclear ring finger protein(gene name synonym)|uniprotkb:RNF4(gene name)|psi-mi:RNF4(display_short)|uniprotkb:RES4-26(orf name)|uniprotkb:RING-type E3 ubiquitin transferase RNF4(gene name synonym)	psi-mi:uba1_human(display_long)|uniprotkb:Ubiquitin-activating enzyme E1(gene name synonym)|uniprotkb:Protein A1S9(gene name synonym)|uniprotkb:UBA1(gene name)|psi-mi:UBA1(display_short)|uniprotkb:A1S9T(gene name synonym)|uniprotkb:UBE1(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9970451|imex:IM-22822-26	author-confidence:Z-score = 18.70	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001171938.1|refseq:NP_001171939.1|refseq:NP_002929.1|ensembl:ENSP00000315212|ensembl:ENSP00000424076|ensembl:ENSP00000426503|ensembl:ENST00000511859|ensembl:ENSP00000426615|ensembl:ENST00000541204|ensembl:ENSP00000446369|ensembl:ENSG00000063978(gene)|ensembl:ENST00000314289(transcript)|ensembl:ENST00000506706(transcript)|ensembl:ENST00000511600(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016604"(nuclear body)|go:"GO:0016605"(PML body)|go:"GO:0030374"(nuclear receptor coactivator activity)|go:"GO:0031491"(nucleosome binding)|go:"GO:0032184"(SUMO polymer binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046685"(response to arsenic-containing substance)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0070936"(protein K48-linked ubiquitination)|go:"GO:0070979"(protein K11-linked ubiquitination)|go:"GO:0085020"(protein K6-linked ubiquitination)|go:"GO:0090169"(regulation of spindle assembly)|go:"GO:0090234"(regulation of kinetochore assembly)|go:"GO:1990752"(microtubule end)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR043295|mint:P78317|rcsb pdb:2EA6|rcsb pdb:2XEU|rcsb pdb:4PPE|reactome:R-HSA-5693607|reactome:R-HSA-983168	refseq:NP_003325.2|refseq:NP_695012.1|refseq:XP_016885269.1|refseq:XP_016885270.1|dip:DIP-33686N|ensembl:ENSG00000130985(gene)|ensembl:ENST00000335972(transcript)|ensembl:ENST00000377351(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0004839"(ubiquitin activating enzyme activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0032446"(protein modification by small protein conjugation)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000011(Ubiquitin-activating enzyme, E1)|interpro:IPR000594(UBA/THIF-type NAD/FAD binding fold)|interpro:IPR018074|interpro:IPR018075|interpro:IPR018965|interpro:IPR019572|interpro:IPR032418|interpro:IPR032420|interpro:IPR033127|interpro:IPR035985|interpro:IPR038252|interpro:IPR042063|interpro:IPR042302|interpro:IPR042449|mint:P22314|rcsb pdb:4P22|rcsb pdb:6DC6|reactome:R-HSA-8866652|reactome:R-HSA-983168	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S2|caution:"UBE2N has been marked as the enzyme in this assay, although it is the UBE2N-UBE2V1 complex that has ubiquitinase (E3) activity. Neither UBE2N nor UBE2V1 have E2 or E3 activity on their own."|resulting-ptm:P78317 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:Yhu2iAaNQYcfGdYohDPBdhMFEpc9606	rogid:q+vEeA0XLST0Zz173bmEt0dNbDE9606	intact-crc:199989D4D7E41A19|rigid:L470Pa3v+EQZh4y2zEIDFbHP/Ys	false	-	his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P78317	uniprotkb:P61088	intact:EBI-2340927|uniprotkb:Q49AR8|uniprotkb:B2R6D6|uniprotkb:D6RF58|intact:EBI-28970119|ensembl:ENSP00000315212|ensembl:ENSP00000424076|ensembl:ENSP00000426503	intact:EBI-1052908|uniprotkb:Q16781|uniprotkb:Q53Y81|ensembl:ENSP00000316176	psi-mi:rnf4_human(display_long)|uniprotkb:SNURF(gene name synonym)|uniprotkb:RING finger protein 4(gene name synonym)|uniprotkb:Small nuclear ring finger protein(gene name synonym)|uniprotkb:RNF4(gene name)|psi-mi:RNF4(display_short)|uniprotkb:RES4-26(orf name)|uniprotkb:RING-type E3 ubiquitin transferase RNF4(gene name synonym)	psi-mi:ube2n_human(display_long)|uniprotkb:Ubiquitin-protein ligase N(gene name synonym)|uniprotkb:Ubiquitin carrier protein N(gene name synonym)|uniprotkb:Ubc13(gene name synonym)|uniprotkb:Bendless-like ubiquitin-conjugating enzyme(gene name synonym)|uniprotkb:UBE2N(gene name)|psi-mi:UBE2N(display_short)|uniprotkb:BLU(gene name synonym)|uniprotkb:UbcH13(gene name synonym)|uniprotkb:E2 ubiquitin-conjugating enzyme N(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9970451|imex:IM-22822-26	author-confidence:Z-score = 18.70	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001171938.1|refseq:NP_001171939.1|refseq:NP_002929.1|ensembl:ENSP00000315212|ensembl:ENSP00000424076|ensembl:ENSP00000426503|ensembl:ENST00000511859|ensembl:ENSP00000426615|ensembl:ENST00000541204|ensembl:ENSP00000446369|ensembl:ENSG00000063978(gene)|ensembl:ENST00000314289(transcript)|ensembl:ENST00000506706(transcript)|ensembl:ENST00000511600(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016604"(nuclear body)|go:"GO:0016605"(PML body)|go:"GO:0030374"(nuclear receptor coactivator activity)|go:"GO:0031491"(nucleosome binding)|go:"GO:0032184"(SUMO polymer binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046685"(response to arsenic-containing substance)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0070936"(protein K48-linked ubiquitination)|go:"GO:0070979"(protein K11-linked ubiquitination)|go:"GO:0085020"(protein K6-linked ubiquitination)|go:"GO:0090169"(regulation of spindle assembly)|go:"GO:0090234"(regulation of kinetochore assembly)|go:"GO:1990752"(microtubule end)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR043295|mint:P78317|rcsb pdb:2EA6|rcsb pdb:2XEU|rcsb pdb:4PPE|reactome:R-HSA-5693607|reactome:R-HSA-983168	refseq:NP_003339.1|dip:DIP-29829N|ensembl:ENSG00000177889(gene)|ensembl:ENST00000318066(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000729"(DNA double-strand break processing)|go:"GO:0001650"(fibrillar center)|go:"GO:0003723"(RNA binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006282"(regulation of DNA repair)|go:"GO:0006301"(postreplication repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016574"(histone ubiquitination)|go:"GO:0031058"(positive regulation of histone modification)|go:"GO:0031372"(UBC13-MMS2 complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033182"(regulation of histone ubiquitination)|go:"GO:0035370"(UBC13-UEV1A complex)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0061631"(ubiquitin conjugating enzyme activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070534"(protein K63-linked ubiquitination)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|interpro:IPR023313|rcsb pdb:1J7D|rcsb pdb:2C2V|rcsb pdb:3HCT|rcsb pdb:3HCU|rcsb pdb:3VON|rcsb pdb:3W31|rcsb pdb:4DHI|rcsb pdb:4DHJ|rcsb pdb:4DHZ|rcsb pdb:4IP3|rcsb pdb:4NR3|rcsb pdb:4NRG|rcsb pdb:4NRI|rcsb pdb:4ONL|rcsb pdb:4ONM|rcsb pdb:4ONN|rcsb pdb:4ORH|rcsb pdb:4TKP|rcsb pdb:4WHV|rcsb pdb:5AIT|rcsb pdb:5AIU|rcsb pdb:5EYA|rcsb pdb:5H7S|rcsb pdb:5VNZ|rcsb pdb:5VO0|rcsb pdb:5YWR|rcsb pdb:6D6I|rcsb pdb:6JKY|rcsb pdb:6KFP|rcsb pdb:6KG6|rcsb pdb:6KL4|rcsb pdb:6LP2|rcsb pdb:6P5B|rcsb pdb:6S53|reactome:R-HSA-168927|reactome:R-HSA-202424|reactome:R-HSA-2871837|reactome:R-HSA-445989|reactome:R-HSA-450302|reactome:R-HSA-450321|reactome:R-HSA-5607764|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-5696395|reactome:R-HSA-69473|reactome:R-HSA-8866654|reactome:R-HSA-9020702|reactome:R-HSA-937039|reactome:R-HSA-937041|reactome:R-HSA-9646399|reactome:R-HSA-975110|reactome:R-HSA-975144|reactome:R-HSA-983168|rcsb pdb:6ULH|rcsb pdb:6UMP|rcsb pdb:6UMS|rcsb pdb:7BBD|rcsb pdb:7BBF|rcsb pdb:7BXG|reactome:R-HSA-1169408|reactome:R-HSA-168638	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S2|caution:"UBE2N has been marked as the enzyme in this assay, although it is the UBE2N-UBE2V1 complex that has ubiquitinase (E3) activity. Neither UBE2N nor UBE2V1 have E2 or E3 activity on their own."|resulting-ptm:P78317 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:Yhu2iAaNQYcfGdYohDPBdhMFEpc9606	rogid:dqdszHlq5FLPHC6UWX6uvkC6Yz89606	intact-crc:199989D4D7E41A19|rigid:L470Pa3v+EQZh4y2zEIDFbHP/Ys	false	-	his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q13404	uniprotkb:P22314	intact:EBI-1050671|uniprotkb:Q13403|uniprotkb:Q13532|uniprotkb:Q96H34|uniprotkb:Q9GZT0|uniprotkb:Q9GZW1|uniprotkb:Q9H4J3|uniprotkb:Q9H4J4|uniprotkb:Q9UKL1|uniprotkb:Q9UM48|uniprotkb:Q9UM49|uniprotkb:Q9UM50|uniprotkb:Q5TGE3|uniprotkb:E1P629|uniprotkb:Q5TGE0|ensembl:ENSP00000360739	intact:EBI-709688|uniprotkb:Q96E13|uniprotkb:Q5JRR8|ensembl:ENSP00000338413|ensembl:ENSP00000366568	psi-mi:ub2v1_human(display_long)|uniprotkb:CROC-1(gene name synonym)|uniprotkb:TRAF6-regulated IKK activator 1 beta Uev1A(gene name synonym)|uniprotkb:P/OKcl.19(orf name)|uniprotkb:UBE2V1(gene name)|psi-mi:UBE2V1(display_short)|uniprotkb:CROC1(gene name synonym)|uniprotkb:UBE2V(gene name synonym)|uniprotkb:UEV1(gene name synonym)	psi-mi:uba1_human(display_long)|uniprotkb:Ubiquitin-activating enzyme E1(gene name synonym)|uniprotkb:Protein A1S9(gene name synonym)|uniprotkb:UBA1(gene name)|psi-mi:UBA1(display_short)|uniprotkb:A1S9T(gene name synonym)|uniprotkb:UBE1(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9970472|imex:IM-22822-27	author-confidence:Z-score = 18.68	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001027459.1|refseq:NP_068823.2|refseq:NP_071887.1|refseq:NP_954595.1|refseq:NP_954673.1|refseq:NP_001244322.1|refseq:NP_001244323.1|refseq:NP_001244325.1|ensembl:ENSG00000244687(gene)|ensembl:ENST00000371674(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006282"(regulation of DNA repair)|go:"GO:0006301"(postreplication repair)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0030154"(cell differentiation)|go:"GO:0031371"(ubiquitin conjugating enzyme complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035370"(UBC13-UEV1A complex)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070534"(protein K63-linked ubiquitination)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|rcsb pdb:2A4D|rcsb pdb:2C2V|rcsb pdb:2HLW|rcsb pdb:6D6I|reactome:R-HSA-168638|reactome:R-HSA-168927|reactome:R-HSA-202424|reactome:R-HSA-2871837|reactome:R-HSA-445989|reactome:R-HSA-450302|reactome:R-HSA-450321|reactome:R-HSA-5607764|reactome:R-HSA-9020702|reactome:R-HSA-937039|reactome:R-HSA-937041|reactome:R-HSA-9646399|reactome:R-HSA-975110|reactome:R-HSA-975144|reactome:R-HSA-983168|dip:DIP-41911N	refseq:NP_003325.2|refseq:NP_695012.1|refseq:XP_016885269.1|refseq:XP_016885270.1|dip:DIP-33686N|ensembl:ENSG00000130985(gene)|ensembl:ENST00000335972(transcript)|ensembl:ENST00000377351(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0004839"(ubiquitin activating enzyme activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0032446"(protein modification by small protein conjugation)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000011(Ubiquitin-activating enzyme, E1)|interpro:IPR000594(UBA/THIF-type NAD/FAD binding fold)|interpro:IPR018074|interpro:IPR018075|interpro:IPR018965|interpro:IPR019572|interpro:IPR032418|interpro:IPR032420|interpro:IPR033127|interpro:IPR035985|interpro:IPR038252|interpro:IPR042063|interpro:IPR042302|interpro:IPR042449|mint:P22314|rcsb pdb:4P22|rcsb pdb:6DC6|reactome:R-HSA-8866652|reactome:R-HSA-983168	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S2|caution:"UBE2N has been marked as the enzyme in this assay, although it is the UBE2N-UBE2V1 complex that has ubiquitinase (E3) activity. Neither UBE2N nor UBE2V1 have E2 or E3 activity on their own."|resulting-ptm:P98170 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:x95N7Dj2KIqu5gySX59xLmfthUg9606	rogid:q+vEeA0XLST0Zz173bmEt0dNbDE9606	intact-crc:EF901702DBA64F5D|rigid:Q0PillPk1TQuSUACE5WBH4J16jQ	false	his tag:?-?	his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q13404	uniprotkb:P61088	intact:EBI-1050671|uniprotkb:Q13403|uniprotkb:Q13532|uniprotkb:Q96H34|uniprotkb:Q9GZT0|uniprotkb:Q9GZW1|uniprotkb:Q9H4J3|uniprotkb:Q9H4J4|uniprotkb:Q9UKL1|uniprotkb:Q9UM48|uniprotkb:Q9UM49|uniprotkb:Q9UM50|uniprotkb:Q5TGE3|uniprotkb:E1P629|uniprotkb:Q5TGE0|ensembl:ENSP00000360739	intact:EBI-1052908|uniprotkb:Q16781|uniprotkb:Q53Y81|ensembl:ENSP00000316176	psi-mi:ub2v1_human(display_long)|uniprotkb:CROC-1(gene name synonym)|uniprotkb:TRAF6-regulated IKK activator 1 beta Uev1A(gene name synonym)|uniprotkb:P/OKcl.19(orf name)|uniprotkb:UBE2V1(gene name)|psi-mi:UBE2V1(display_short)|uniprotkb:CROC1(gene name synonym)|uniprotkb:UBE2V(gene name synonym)|uniprotkb:UEV1(gene name synonym)	psi-mi:ube2n_human(display_long)|uniprotkb:Ubiquitin-protein ligase N(gene name synonym)|uniprotkb:Ubiquitin carrier protein N(gene name synonym)|uniprotkb:Ubc13(gene name synonym)|uniprotkb:Bendless-like ubiquitin-conjugating enzyme(gene name synonym)|uniprotkb:UBE2N(gene name)|psi-mi:UBE2N(display_short)|uniprotkb:BLU(gene name synonym)|uniprotkb:UbcH13(gene name synonym)|uniprotkb:E2 ubiquitin-conjugating enzyme N(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9970472|imex:IM-22822-27	author-confidence:Z-score = 18.68	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001027459.1|refseq:NP_068823.2|refseq:NP_071887.1|refseq:NP_954595.1|refseq:NP_954673.1|refseq:NP_001244322.1|refseq:NP_001244323.1|refseq:NP_001244325.1|ensembl:ENSG00000244687(gene)|ensembl:ENST00000371674(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006282"(regulation of DNA repair)|go:"GO:0006301"(postreplication repair)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0030154"(cell differentiation)|go:"GO:0031371"(ubiquitin conjugating enzyme complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035370"(UBC13-UEV1A complex)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070534"(protein K63-linked ubiquitination)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|rcsb pdb:2A4D|rcsb pdb:2C2V|rcsb pdb:2HLW|rcsb pdb:6D6I|reactome:R-HSA-168638|reactome:R-HSA-168927|reactome:R-HSA-202424|reactome:R-HSA-2871837|reactome:R-HSA-445989|reactome:R-HSA-450302|reactome:R-HSA-450321|reactome:R-HSA-5607764|reactome:R-HSA-9020702|reactome:R-HSA-937039|reactome:R-HSA-937041|reactome:R-HSA-9646399|reactome:R-HSA-975110|reactome:R-HSA-975144|reactome:R-HSA-983168|dip:DIP-41911N	refseq:NP_003339.1|dip:DIP-29829N|ensembl:ENSG00000177889(gene)|ensembl:ENST00000318066(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000729"(DNA double-strand break processing)|go:"GO:0001650"(fibrillar center)|go:"GO:0003723"(RNA binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006282"(regulation of DNA repair)|go:"GO:0006301"(postreplication repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016574"(histone ubiquitination)|go:"GO:0031058"(positive regulation of histone modification)|go:"GO:0031372"(UBC13-MMS2 complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033182"(regulation of histone ubiquitination)|go:"GO:0035370"(UBC13-UEV1A complex)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0061631"(ubiquitin conjugating enzyme activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070534"(protein K63-linked ubiquitination)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|interpro:IPR023313|rcsb pdb:1J7D|rcsb pdb:2C2V|rcsb pdb:3HCT|rcsb pdb:3HCU|rcsb pdb:3VON|rcsb pdb:3W31|rcsb pdb:4DHI|rcsb pdb:4DHJ|rcsb pdb:4DHZ|rcsb pdb:4IP3|rcsb pdb:4NR3|rcsb pdb:4NRG|rcsb pdb:4NRI|rcsb pdb:4ONL|rcsb pdb:4ONM|rcsb pdb:4ONN|rcsb pdb:4ORH|rcsb pdb:4TKP|rcsb pdb:4WHV|rcsb pdb:5AIT|rcsb pdb:5AIU|rcsb pdb:5EYA|rcsb pdb:5H7S|rcsb pdb:5VNZ|rcsb pdb:5VO0|rcsb pdb:5YWR|rcsb pdb:6D6I|rcsb pdb:6JKY|rcsb pdb:6KFP|rcsb pdb:6KG6|rcsb pdb:6KL4|rcsb pdb:6LP2|rcsb pdb:6P5B|rcsb pdb:6S53|reactome:R-HSA-168927|reactome:R-HSA-202424|reactome:R-HSA-2871837|reactome:R-HSA-445989|reactome:R-HSA-450302|reactome:R-HSA-450321|reactome:R-HSA-5607764|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-5696395|reactome:R-HSA-69473|reactome:R-HSA-8866654|reactome:R-HSA-9020702|reactome:R-HSA-937039|reactome:R-HSA-937041|reactome:R-HSA-9646399|reactome:R-HSA-975110|reactome:R-HSA-975144|reactome:R-HSA-983168|rcsb pdb:6ULH|rcsb pdb:6UMP|rcsb pdb:6UMS|rcsb pdb:7BBD|rcsb pdb:7BBF|rcsb pdb:7BXG|reactome:R-HSA-1169408|reactome:R-HSA-168638	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S2|caution:"UBE2N has been marked as the enzyme in this assay, although it is the UBE2N-UBE2V1 complex that has ubiquitinase (E3) activity. Neither UBE2N nor UBE2V1 have E2 or E3 activity on their own."|resulting-ptm:P98170 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:x95N7Dj2KIqu5gySX59xLmfthUg9606	rogid:dqdszHlq5FLPHC6UWX6uvkC6Yz89606	intact-crc:EF901702DBA64F5D|rigid:Q0PillPk1TQuSUACE5WBH4J16jQ	false	his tag:?-?	his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q13404	uniprotkb:P98170	intact:EBI-1050671|uniprotkb:Q13403|uniprotkb:Q13532|uniprotkb:Q96H34|uniprotkb:Q9GZT0|uniprotkb:Q9GZW1|uniprotkb:Q9H4J3|uniprotkb:Q9H4J4|uniprotkb:Q9UKL1|uniprotkb:Q9UM48|uniprotkb:Q9UM49|uniprotkb:Q9UM50|uniprotkb:Q5TGE3|uniprotkb:E1P629|uniprotkb:Q5TGE0|ensembl:ENSP00000360739	intact:EBI-517127|uniprotkb:Q9NQ14|uniprotkb:D3DTF2|ensembl:ENSP00000347858|ensembl:ENSP00000360242|ensembl:ENSP00000395230	psi-mi:ub2v1_human(display_long)|uniprotkb:CROC-1(gene name synonym)|uniprotkb:TRAF6-regulated IKK activator 1 beta Uev1A(gene name synonym)|uniprotkb:P/OKcl.19(orf name)|uniprotkb:UBE2V1(gene name)|psi-mi:UBE2V1(display_short)|uniprotkb:CROC1(gene name synonym)|uniprotkb:UBE2V(gene name synonym)|uniprotkb:UEV1(gene name synonym)	psi-mi:xiap_human(display_long)|uniprotkb:Inhibitor of apoptosis protein 3(gene name synonym)|uniprotkb:X-linked inhibitor of apoptosis protein(gene name synonym)|uniprotkb:IAP-like protein(gene name synonym)|uniprotkb:XIAP(gene name)|psi-mi:XIAP(display_short)|uniprotkb:API3(gene name synonym)|uniprotkb:IAP3(gene name synonym)|uniprotkb:BIRC4(gene name synonym)|uniprotkb:Baculoviral IAP repeat-containing protein 4(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase XIAP(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9970472|imex:IM-22822-27	author-confidence:Z-score = 18.68	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001027459.1|refseq:NP_068823.2|refseq:NP_071887.1|refseq:NP_954595.1|refseq:NP_954673.1|refseq:NP_001244322.1|refseq:NP_001244323.1|refseq:NP_001244325.1|ensembl:ENSG00000244687(gene)|ensembl:ENST00000371674(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006282"(regulation of DNA repair)|go:"GO:0006301"(postreplication repair)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0030154"(cell differentiation)|go:"GO:0031371"(ubiquitin conjugating enzyme complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035370"(UBC13-UEV1A complex)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070534"(protein K63-linked ubiquitination)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|rcsb pdb:2A4D|rcsb pdb:2C2V|rcsb pdb:2HLW|rcsb pdb:6D6I|reactome:R-HSA-168638|reactome:R-HSA-168927|reactome:R-HSA-202424|reactome:R-HSA-2871837|reactome:R-HSA-445989|reactome:R-HSA-450302|reactome:R-HSA-450321|reactome:R-HSA-5607764|reactome:R-HSA-9020702|reactome:R-HSA-937039|reactome:R-HSA-937041|reactome:R-HSA-9646399|reactome:R-HSA-975110|reactome:R-HSA-975144|reactome:R-HSA-983168|dip:DIP-41911N	refseq:XP_006724817.1|refseq:NP_001158.2|refseq:NP_001191330.1|refseq:XP_011529631.1|dip:DIP-27626N|ensembl:ENSG00000101966(gene)|ensembl:ENST00000355640(transcript)|ensembl:ENST00000371199(transcript)|ensembl:ENST00000434753(transcript)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005876"(spindle microtubule)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0030510"(regulation of BMP signaling pathway)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043027"(cysteine-type endopeptidase inhibitor activity involved in apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0045088"(regulation of innate immune response)|go:"GO:0046872"(metal ion binding)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0055070"(copper ion homeostasis)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070424"(regulation of nucleotide-binding oligomerization domain containing signaling pathway)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:1902530"(positive regulation of protein linear polyubiquitination)|go:"GO:1990001"(inhibition of cysteine-type endopeptidase activity involved in apoptotic process)|interpro:IPR001370(Proteinase inhibitor I32, inhibitor of apoptosis)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR011029(DEATH-like)|interpro:IPR042579|mint:P98170|rcsb pdb:1C9Q|rcsb pdb:1F9X|rcsb pdb:1G3F|rcsb pdb:1G73|rcsb pdb:1I3O|rcsb pdb:1I4O|rcsb pdb:1I51|rcsb pdb:1KMC|rcsb pdb:1NW9|rcsb pdb:1TFQ|rcsb pdb:1TFT|rcsb pdb:2ECG|rcsb pdb:2JK7|rcsb pdb:2KNA|rcsb pdb:2OPY|rcsb pdb:2OPZ|rcsb pdb:2POI|rcsb pdb:2POP|rcsb pdb:2QRA|rcsb pdb:2VSL|rcsb pdb:3CLX|rcsb pdb:3CM2|rcsb pdb:3CM7|rcsb pdb:3EYL|rcsb pdb:3G76|rcsb pdb:3HL5|rcsb pdb:3UW4|rcsb pdb:3UW5|rcsb pdb:4EC4|rcsb pdb:4HY0|rcsb pdb:4IC2|rcsb pdb:4IC3|rcsb pdb:4J3Y|rcsb pdb:4J44|rcsb pdb:4J45|rcsb pdb:4J46|rcsb pdb:4J47|rcsb pdb:4J48|rcsb pdb:4KJU|rcsb pdb:4KJV|rcsb pdb:4KMP|rcsb pdb:4MTZ|rcsb pdb:4OXC|rcsb pdb:4WVS|rcsb pdb:4WVT|rcsb pdb:4WVU|rcsb pdb:5C0K|rcsb pdb:5C0L|rcsb pdb:5C3H|rcsb pdb:5C3K|rcsb pdb:5C7A|rcsb pdb:5C7B|rcsb pdb:5C7C|rcsb pdb:5C7D|rcsb pdb:5C83|rcsb pdb:5C84|rcsb pdb:5M6E|rcsb pdb:5M6F|rcsb pdb:5M6H|rcsb pdb:5M6L|rcsb pdb:5M6M|rcsb pdb:5O6T|rcsb pdb:5OQW|rcsb pdb:6EY2|rcsb pdb:6GJW|rcsb pdb:6QCI|reactome:R-HSA-111459|reactome:R-HSA-111463|reactome:R-HSA-111464|reactome:R-HSA-111469|reactome:R-HSA-3769402|reactome:R-HSA-5213460|reactome:R-HSA-5357905|reactome:R-HSA-5357956|reactome:R-HSA-5675482|reactome:R-HSA-8948747|reactome:R-HSA-8948751|reactome:R-HSA-9627069	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S2|caution:"UBE2N has been marked as the enzyme in this assay, although it is the UBE2N-UBE2V1 complex that has ubiquitinase (E3) activity. Neither UBE2N nor UBE2V1 have E2 or E3 activity on their own."|resulting-ptm:P98170 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:x95N7Dj2KIqu5gySX59xLmfthUg9606	rogid:6eDcOay+c2ZmIAD/pwnCDROBwgM9606	intact-crc:EF901702DBA64F5D|rigid:Q0PillPk1TQuSUACE5WBH4J16jQ	false	his tag:?-?	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q13191	uniprotkb:Q13404	intact:EBI-744027|uniprotkb:Q63Z43|uniprotkb:A8K9S7|uniprotkb:Q13192|uniprotkb:Q13193|uniprotkb:Q3LIC0|uniprotkb:Q8IVC5|uniprotkb:B7WNM4|intact:EBI-28969458|ensembl:ENSP00000377598|intact:EBI-8051403|intact:MINT-7907019	intact:EBI-1050671|uniprotkb:Q13403|uniprotkb:Q13532|uniprotkb:Q96H34|uniprotkb:Q9GZT0|uniprotkb:Q9GZW1|uniprotkb:Q9H4J3|uniprotkb:Q9H4J4|uniprotkb:Q9UKL1|uniprotkb:Q9UM48|uniprotkb:Q9UM49|uniprotkb:Q9UM50|uniprotkb:Q5TGE3|uniprotkb:E1P629|uniprotkb:Q5TGE0|ensembl:ENSP00000360739	psi-mi:cblb_human(display_long)|uniprotkb:Signal transduction protein CBL-B(gene name synonym)|uniprotkb:SH3-binding protein CBL-B(gene name synonym)|uniprotkb:Casitas B-lineage lymphoma proto-oncogene b(gene name synonym)|uniprotkb:RING finger protein 56(gene name synonym)|uniprotkb:CBLB(gene name)|psi-mi:CBLB(display_short)|uniprotkb:RNF56(gene name synonym)|uniprotkb:Nbla00127(orf name)|uniprotkb:RING-type E3 ubiquitin transferase CBL-B(gene name synonym)	psi-mi:ub2v1_human(display_long)|uniprotkb:CROC-1(gene name synonym)|uniprotkb:TRAF6-regulated IKK activator 1 beta Uev1A(gene name synonym)|uniprotkb:P/OKcl.19(orf name)|uniprotkb:UBE2V1(gene name)|psi-mi:UBE2V1(display_short)|uniprotkb:CROC1(gene name synonym)|uniprotkb:UBE2V(gene name synonym)|uniprotkb:UEV1(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9970536|imex:IM-22822-30	author-confidence:Z-score = 10.90	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_733762.2|refseq:NP_001308717.1|ensembl:ENSP00000377598|ensembl:ENST00000403724|ensembl:ENSP00000384816|ensembl:ENST00000405772|ensembl:ENSP00000384938|refseq:XP_011511559.1|ensembl:ENSG00000114423(gene)|ensembl:ENST00000394030(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0002669"(positive regulation of T cell anergy)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006607"(NLS-bearing protein import into nucleus)|go:"GO:0006955"(immune response)|go:"GO:0007165"(signal transduction)|go:"GO:0007175"(negative regulation of epidermal growth factor-activated receptor activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0018193"(peptidyl-amino acid modification)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0005829"(cytosol)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042110"(T cell activation)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0046642"(negative regulation of alpha-beta T cell proliferation)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0050860"(negative regulation of T cell receptor signaling pathway)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:2000583"(regulation of platelet-derived growth factor receptor-alpha signaling pathway)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR003153(Adaptor protein Cbl, N-terminal helical)|interpro:IPR011992(EF-Hand type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR014742(Adaptor protein Cbl, SH2-like)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR017907|interpro:IPR024159|interpro:IPR024162|interpro:IPR036537|interpro:IPR036860|interpro:IPR039520|mint:Q13191|rcsb pdb:2AK5|rcsb pdb:2BZ8|rcsb pdb:2DO6|rcsb pdb:2J6F|rcsb pdb:2JNH|rcsb pdb:2LDR|rcsb pdb:2OOA|rcsb pdb:2OOB|rcsb pdb:3PFV|rcsb pdb:3VGO|rcsb pdb:3ZNI|reactome:R-HSA-983168|interpro:IPR014741(Adaptor protein Cbl, EF hand-like)|dip:DIP-33091N	refseq:NP_001027459.1|refseq:NP_068823.2|refseq:NP_071887.1|refseq:NP_954595.1|refseq:NP_954673.1|refseq:NP_001244322.1|refseq:NP_001244323.1|refseq:NP_001244325.1|ensembl:ENSG00000244687(gene)|ensembl:ENST00000371674(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006282"(regulation of DNA repair)|go:"GO:0006301"(postreplication repair)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0030154"(cell differentiation)|go:"GO:0031371"(ubiquitin conjugating enzyme complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035370"(UBC13-UEV1A complex)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070534"(protein K63-linked ubiquitination)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|rcsb pdb:2A4D|rcsb pdb:2C2V|rcsb pdb:2HLW|rcsb pdb:6D6I|reactome:R-HSA-168638|reactome:R-HSA-168927|reactome:R-HSA-202424|reactome:R-HSA-2871837|reactome:R-HSA-445989|reactome:R-HSA-450302|reactome:R-HSA-450321|reactome:R-HSA-5607764|reactome:R-HSA-9020702|reactome:R-HSA-937039|reactome:R-HSA-937041|reactome:R-HSA-9646399|reactome:R-HSA-975110|reactome:R-HSA-975144|reactome:R-HSA-983168|dip:DIP-41911N	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S2|caution:"UBE2N has been marked as the enzyme in this assay, although it is the UBE2N-UBE2V1 complex that has ubiquitinase (E3) activity. Neither UBE2N nor UBE2V1 have E2 or E3 activity on their own."|resulting-ptm:Q13191 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:cJ5eLH0TMyM6OtmS1sM3rhsrsIk9606	rogid:x95N7Dj2KIqu5gySX59xLmfthUg9606	intact-crc:B32F8E70FA03065E|rigid:GwtTodl8XonU6Q+25gnEBZLUptA	false	-	his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q13191	uniprotkb:P22314	intact:EBI-744027|uniprotkb:Q63Z43|uniprotkb:A8K9S7|uniprotkb:Q13192|uniprotkb:Q13193|uniprotkb:Q3LIC0|uniprotkb:Q8IVC5|uniprotkb:B7WNM4|intact:EBI-28969458|ensembl:ENSP00000377598|intact:EBI-8051403|intact:MINT-7907019	intact:EBI-709688|uniprotkb:Q96E13|uniprotkb:Q5JRR8|ensembl:ENSP00000338413|ensembl:ENSP00000366568	psi-mi:cblb_human(display_long)|uniprotkb:Signal transduction protein CBL-B(gene name synonym)|uniprotkb:SH3-binding protein CBL-B(gene name synonym)|uniprotkb:Casitas B-lineage lymphoma proto-oncogene b(gene name synonym)|uniprotkb:RING finger protein 56(gene name synonym)|uniprotkb:CBLB(gene name)|psi-mi:CBLB(display_short)|uniprotkb:RNF56(gene name synonym)|uniprotkb:Nbla00127(orf name)|uniprotkb:RING-type E3 ubiquitin transferase CBL-B(gene name synonym)	psi-mi:uba1_human(display_long)|uniprotkb:Ubiquitin-activating enzyme E1(gene name synonym)|uniprotkb:Protein A1S9(gene name synonym)|uniprotkb:UBA1(gene name)|psi-mi:UBA1(display_short)|uniprotkb:A1S9T(gene name synonym)|uniprotkb:UBE1(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9970536|imex:IM-22822-30	author-confidence:Z-score = 10.90	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_733762.2|refseq:NP_001308717.1|ensembl:ENSP00000377598|ensembl:ENST00000403724|ensembl:ENSP00000384816|ensembl:ENST00000405772|ensembl:ENSP00000384938|refseq:XP_011511559.1|ensembl:ENSG00000114423(gene)|ensembl:ENST00000394030(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0002669"(positive regulation of T cell anergy)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006607"(NLS-bearing protein import into nucleus)|go:"GO:0006955"(immune response)|go:"GO:0007165"(signal transduction)|go:"GO:0007175"(negative regulation of epidermal growth factor-activated receptor activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0018193"(peptidyl-amino acid modification)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0005829"(cytosol)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042110"(T cell activation)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0046642"(negative regulation of alpha-beta T cell proliferation)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0050860"(negative regulation of T cell receptor signaling pathway)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:2000583"(regulation of platelet-derived growth factor receptor-alpha signaling pathway)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR003153(Adaptor protein Cbl, N-terminal helical)|interpro:IPR011992(EF-Hand type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR014742(Adaptor protein Cbl, SH2-like)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR017907|interpro:IPR024159|interpro:IPR024162|interpro:IPR036537|interpro:IPR036860|interpro:IPR039520|mint:Q13191|rcsb pdb:2AK5|rcsb pdb:2BZ8|rcsb pdb:2DO6|rcsb pdb:2J6F|rcsb pdb:2JNH|rcsb pdb:2LDR|rcsb pdb:2OOA|rcsb pdb:2OOB|rcsb pdb:3PFV|rcsb pdb:3VGO|rcsb pdb:3ZNI|reactome:R-HSA-983168|interpro:IPR014741(Adaptor protein Cbl, EF hand-like)|dip:DIP-33091N	refseq:NP_003325.2|refseq:NP_695012.1|refseq:XP_016885269.1|refseq:XP_016885270.1|dip:DIP-33686N|ensembl:ENSG00000130985(gene)|ensembl:ENST00000335972(transcript)|ensembl:ENST00000377351(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0004839"(ubiquitin activating enzyme activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0032446"(protein modification by small protein conjugation)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000011(Ubiquitin-activating enzyme, E1)|interpro:IPR000594(UBA/THIF-type NAD/FAD binding fold)|interpro:IPR018074|interpro:IPR018075|interpro:IPR018965|interpro:IPR019572|interpro:IPR032418|interpro:IPR032420|interpro:IPR033127|interpro:IPR035985|interpro:IPR038252|interpro:IPR042063|interpro:IPR042302|interpro:IPR042449|mint:P22314|rcsb pdb:4P22|rcsb pdb:6DC6|reactome:R-HSA-8866652|reactome:R-HSA-983168	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S2|caution:"UBE2N has been marked as the enzyme in this assay, although it is the UBE2N-UBE2V1 complex that has ubiquitinase (E3) activity. Neither UBE2N nor UBE2V1 have E2 or E3 activity on their own."|resulting-ptm:Q13191 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:cJ5eLH0TMyM6OtmS1sM3rhsrsIk9606	rogid:q+vEeA0XLST0Zz173bmEt0dNbDE9606	intact-crc:B32F8E70FA03065E|rigid:GwtTodl8XonU6Q+25gnEBZLUptA	false	-	his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q13191	uniprotkb:P61088	intact:EBI-744027|uniprotkb:Q63Z43|uniprotkb:A8K9S7|uniprotkb:Q13192|uniprotkb:Q13193|uniprotkb:Q3LIC0|uniprotkb:Q8IVC5|uniprotkb:B7WNM4|intact:EBI-28969458|ensembl:ENSP00000377598|intact:EBI-8051403|intact:MINT-7907019	intact:EBI-1052908|uniprotkb:Q16781|uniprotkb:Q53Y81|ensembl:ENSP00000316176	psi-mi:cblb_human(display_long)|uniprotkb:Signal transduction protein CBL-B(gene name synonym)|uniprotkb:SH3-binding protein CBL-B(gene name synonym)|uniprotkb:Casitas B-lineage lymphoma proto-oncogene b(gene name synonym)|uniprotkb:RING finger protein 56(gene name synonym)|uniprotkb:CBLB(gene name)|psi-mi:CBLB(display_short)|uniprotkb:RNF56(gene name synonym)|uniprotkb:Nbla00127(orf name)|uniprotkb:RING-type E3 ubiquitin transferase CBL-B(gene name synonym)	psi-mi:ube2n_human(display_long)|uniprotkb:Ubiquitin-protein ligase N(gene name synonym)|uniprotkb:Ubiquitin carrier protein N(gene name synonym)|uniprotkb:Ubc13(gene name synonym)|uniprotkb:Bendless-like ubiquitin-conjugating enzyme(gene name synonym)|uniprotkb:UBE2N(gene name)|psi-mi:UBE2N(display_short)|uniprotkb:BLU(gene name synonym)|uniprotkb:UbcH13(gene name synonym)|uniprotkb:E2 ubiquitin-conjugating enzyme N(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9970536|imex:IM-22822-30	author-confidence:Z-score = 10.90	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_733762.2|refseq:NP_001308717.1|ensembl:ENSP00000377598|ensembl:ENST00000403724|ensembl:ENSP00000384816|ensembl:ENST00000405772|ensembl:ENSP00000384938|refseq:XP_011511559.1|ensembl:ENSG00000114423(gene)|ensembl:ENST00000394030(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0002669"(positive regulation of T cell anergy)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006607"(NLS-bearing protein import into nucleus)|go:"GO:0006955"(immune response)|go:"GO:0007165"(signal transduction)|go:"GO:0007175"(negative regulation of epidermal growth factor-activated receptor activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0018193"(peptidyl-amino acid modification)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0005829"(cytosol)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042110"(T cell activation)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0046642"(negative regulation of alpha-beta T cell proliferation)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0050860"(negative regulation of T cell receptor signaling pathway)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:2000583"(regulation of platelet-derived growth factor receptor-alpha signaling pathway)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR003153(Adaptor protein Cbl, N-terminal helical)|interpro:IPR011992(EF-Hand type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR014742(Adaptor protein Cbl, SH2-like)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR017907|interpro:IPR024159|interpro:IPR024162|interpro:IPR036537|interpro:IPR036860|interpro:IPR039520|mint:Q13191|rcsb pdb:2AK5|rcsb pdb:2BZ8|rcsb pdb:2DO6|rcsb pdb:2J6F|rcsb pdb:2JNH|rcsb pdb:2LDR|rcsb pdb:2OOA|rcsb pdb:2OOB|rcsb pdb:3PFV|rcsb pdb:3VGO|rcsb pdb:3ZNI|reactome:R-HSA-983168|interpro:IPR014741(Adaptor protein Cbl, EF hand-like)|dip:DIP-33091N	refseq:NP_003339.1|dip:DIP-29829N|ensembl:ENSG00000177889(gene)|ensembl:ENST00000318066(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000729"(DNA double-strand break processing)|go:"GO:0001650"(fibrillar center)|go:"GO:0003723"(RNA binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006282"(regulation of DNA repair)|go:"GO:0006301"(postreplication repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016574"(histone ubiquitination)|go:"GO:0031058"(positive regulation of histone modification)|go:"GO:0031372"(UBC13-MMS2 complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033182"(regulation of histone ubiquitination)|go:"GO:0035370"(UBC13-UEV1A complex)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0061631"(ubiquitin conjugating enzyme activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070534"(protein K63-linked ubiquitination)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|interpro:IPR023313|rcsb pdb:1J7D|rcsb pdb:2C2V|rcsb pdb:3HCT|rcsb pdb:3HCU|rcsb pdb:3VON|rcsb pdb:3W31|rcsb pdb:4DHI|rcsb pdb:4DHJ|rcsb pdb:4DHZ|rcsb pdb:4IP3|rcsb pdb:4NR3|rcsb pdb:4NRG|rcsb pdb:4NRI|rcsb pdb:4ONL|rcsb pdb:4ONM|rcsb pdb:4ONN|rcsb pdb:4ORH|rcsb pdb:4TKP|rcsb pdb:4WHV|rcsb pdb:5AIT|rcsb pdb:5AIU|rcsb pdb:5EYA|rcsb pdb:5H7S|rcsb pdb:5VNZ|rcsb pdb:5VO0|rcsb pdb:5YWR|rcsb pdb:6D6I|rcsb pdb:6JKY|rcsb pdb:6KFP|rcsb pdb:6KG6|rcsb pdb:6KL4|rcsb pdb:6LP2|rcsb pdb:6P5B|rcsb pdb:6S53|reactome:R-HSA-168927|reactome:R-HSA-202424|reactome:R-HSA-2871837|reactome:R-HSA-445989|reactome:R-HSA-450302|reactome:R-HSA-450321|reactome:R-HSA-5607764|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-5696395|reactome:R-HSA-69473|reactome:R-HSA-8866654|reactome:R-HSA-9020702|reactome:R-HSA-937039|reactome:R-HSA-937041|reactome:R-HSA-9646399|reactome:R-HSA-975110|reactome:R-HSA-975144|reactome:R-HSA-983168|rcsb pdb:6ULH|rcsb pdb:6UMP|rcsb pdb:6UMS|rcsb pdb:7BBD|rcsb pdb:7BBF|rcsb pdb:7BXG|reactome:R-HSA-1169408|reactome:R-HSA-168638	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S2|caution:"UBE2N has been marked as the enzyme in this assay, although it is the UBE2N-UBE2V1 complex that has ubiquitinase (E3) activity. Neither UBE2N nor UBE2V1 have E2 or E3 activity on their own."|resulting-ptm:Q13191 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:cJ5eLH0TMyM6OtmS1sM3rhsrsIk9606	rogid:dqdszHlq5FLPHC6UWX6uvkC6Yz89606	intact-crc:B32F8E70FA03065E|rigid:GwtTodl8XonU6Q+25gnEBZLUptA	false	-	his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q08DI6	uniprotkb:Q13404	intact:EBI-9916095|ensembl:ENSBTAP00000059090	intact:EBI-1050671|uniprotkb:Q13403|uniprotkb:Q13532|uniprotkb:Q96H34|uniprotkb:Q9GZT0|uniprotkb:Q9GZW1|uniprotkb:Q9H4J3|uniprotkb:Q9H4J4|uniprotkb:Q9UKL1|uniprotkb:Q9UM48|uniprotkb:Q9UM49|uniprotkb:Q9UM50|uniprotkb:Q5TGE3|uniprotkb:E1P629|uniprotkb:Q5TGE0|ensembl:ENSP00000360739	psi-mi:rnf11_bovin(display_long)|uniprotkb:RNF11(gene name)|psi-mi:RNF11(display_short)	psi-mi:ub2v1_human(display_long)|uniprotkb:CROC-1(gene name synonym)|uniprotkb:TRAF6-regulated IKK activator 1 beta Uev1A(gene name synonym)|uniprotkb:P/OKcl.19(orf name)|uniprotkb:UBE2V1(gene name)|psi-mi:UBE2V1(display_short)|uniprotkb:CROC1(gene name synonym)|uniprotkb:UBE2V(gene name synonym)|uniprotkb:UEV1(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:9913(bovin)|taxid:9913("Bos taurus (Bovine)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9970515|imex:IM-22822-29	author-confidence:Z-score = 3.72	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001071421.1|ensembl:ENSBTAG00000054545(gene)|ensembl:ENSBTAT00000086641(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0005634"(nucleus)|go:"GO:0005769"(early endosome)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0055037"(recycling endosome)|go:"GO:0061630"(ubiquitin protein ligase activity)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR042981	refseq:NP_001027459.1|refseq:NP_068823.2|refseq:NP_071887.1|refseq:NP_954595.1|refseq:NP_954673.1|refseq:NP_001244322.1|refseq:NP_001244323.1|refseq:NP_001244325.1|ensembl:ENSG00000244687(gene)|ensembl:ENST00000371674(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006282"(regulation of DNA repair)|go:"GO:0006301"(postreplication repair)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0030154"(cell differentiation)|go:"GO:0031371"(ubiquitin conjugating enzyme complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035370"(UBC13-UEV1A complex)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070534"(protein K63-linked ubiquitination)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|rcsb pdb:2A4D|rcsb pdb:2C2V|rcsb pdb:2HLW|rcsb pdb:6D6I|reactome:R-HSA-168638|reactome:R-HSA-168927|reactome:R-HSA-202424|reactome:R-HSA-2871837|reactome:R-HSA-445989|reactome:R-HSA-450302|reactome:R-HSA-450321|reactome:R-HSA-5607764|reactome:R-HSA-9020702|reactome:R-HSA-937039|reactome:R-HSA-937041|reactome:R-HSA-9646399|reactome:R-HSA-975110|reactome:R-HSA-975144|reactome:R-HSA-983168|dip:DIP-41911N	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S2|caution:"UBE2N has been marked as the enzyme in this assay, although it is the UBE2N-UBE2V1 complex that has ubiquitinase (E3) activity. Neither UBE2N nor UBE2V1 have E2 or E3 activity on their own."|resulting-ptm:Q08DI6 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:Uj0YAf/t+AdYbMd6fgQ8hVKoP0w9913	rogid:x95N7Dj2KIqu5gySX59xLmfthUg9606	intact-crc:965FD8A45FFC52C0|rigid:Kvh/38tvuePo1OJbasMwmwG696c	false	-	his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q08DI6	uniprotkb:P22314	intact:EBI-9916095|ensembl:ENSBTAP00000059090	intact:EBI-709688|uniprotkb:Q96E13|uniprotkb:Q5JRR8|ensembl:ENSP00000338413|ensembl:ENSP00000366568	psi-mi:rnf11_bovin(display_long)|uniprotkb:RNF11(gene name)|psi-mi:RNF11(display_short)	psi-mi:uba1_human(display_long)|uniprotkb:Ubiquitin-activating enzyme E1(gene name synonym)|uniprotkb:Protein A1S9(gene name synonym)|uniprotkb:UBA1(gene name)|psi-mi:UBA1(display_short)|uniprotkb:A1S9T(gene name synonym)|uniprotkb:UBE1(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:9913(bovin)|taxid:9913("Bos taurus (Bovine)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9970515|imex:IM-22822-29	author-confidence:Z-score = 3.72	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001071421.1|ensembl:ENSBTAG00000054545(gene)|ensembl:ENSBTAT00000086641(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0005634"(nucleus)|go:"GO:0005769"(early endosome)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0055037"(recycling endosome)|go:"GO:0061630"(ubiquitin protein ligase activity)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR042981	refseq:NP_003325.2|refseq:NP_695012.1|refseq:XP_016885269.1|refseq:XP_016885270.1|dip:DIP-33686N|ensembl:ENSG00000130985(gene)|ensembl:ENST00000335972(transcript)|ensembl:ENST00000377351(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0004839"(ubiquitin activating enzyme activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0032446"(protein modification by small protein conjugation)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000011(Ubiquitin-activating enzyme, E1)|interpro:IPR000594(UBA/THIF-type NAD/FAD binding fold)|interpro:IPR018074|interpro:IPR018075|interpro:IPR018965|interpro:IPR019572|interpro:IPR032418|interpro:IPR032420|interpro:IPR033127|interpro:IPR035985|interpro:IPR038252|interpro:IPR042063|interpro:IPR042302|interpro:IPR042449|mint:P22314|rcsb pdb:4P22|rcsb pdb:6DC6|reactome:R-HSA-8866652|reactome:R-HSA-983168	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S2|caution:"UBE2N has been marked as the enzyme in this assay, although it is the UBE2N-UBE2V1 complex that has ubiquitinase (E3) activity. Neither UBE2N nor UBE2V1 have E2 or E3 activity on their own."|resulting-ptm:Q08DI6 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:Uj0YAf/t+AdYbMd6fgQ8hVKoP0w9913	rogid:q+vEeA0XLST0Zz173bmEt0dNbDE9606	intact-crc:965FD8A45FFC52C0|rigid:Kvh/38tvuePo1OJbasMwmwG696c	false	-	his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q08DI6	uniprotkb:P61088	intact:EBI-9916095|ensembl:ENSBTAP00000059090	intact:EBI-1052908|uniprotkb:Q16781|uniprotkb:Q53Y81|ensembl:ENSP00000316176	psi-mi:rnf11_bovin(display_long)|uniprotkb:RNF11(gene name)|psi-mi:RNF11(display_short)	psi-mi:ube2n_human(display_long)|uniprotkb:Ubiquitin-protein ligase N(gene name synonym)|uniprotkb:Ubiquitin carrier protein N(gene name synonym)|uniprotkb:Ubc13(gene name synonym)|uniprotkb:Bendless-like ubiquitin-conjugating enzyme(gene name synonym)|uniprotkb:UBE2N(gene name)|psi-mi:UBE2N(display_short)|uniprotkb:BLU(gene name synonym)|uniprotkb:UbcH13(gene name synonym)|uniprotkb:E2 ubiquitin-conjugating enzyme N(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:9913(bovin)|taxid:9913("Bos taurus (Bovine)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9970515|imex:IM-22822-29	author-confidence:Z-score = 3.72	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001071421.1|ensembl:ENSBTAG00000054545(gene)|ensembl:ENSBTAT00000086641(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0005634"(nucleus)|go:"GO:0005769"(early endosome)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0055037"(recycling endosome)|go:"GO:0061630"(ubiquitin protein ligase activity)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR042981	refseq:NP_003339.1|dip:DIP-29829N|ensembl:ENSG00000177889(gene)|ensembl:ENST00000318066(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000729"(DNA double-strand break processing)|go:"GO:0001650"(fibrillar center)|go:"GO:0003723"(RNA binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006282"(regulation of DNA repair)|go:"GO:0006301"(postreplication repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016574"(histone ubiquitination)|go:"GO:0031058"(positive regulation of histone modification)|go:"GO:0031372"(UBC13-MMS2 complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033182"(regulation of histone ubiquitination)|go:"GO:0035370"(UBC13-UEV1A complex)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0061631"(ubiquitin conjugating enzyme activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070534"(protein K63-linked ubiquitination)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|interpro:IPR023313|rcsb pdb:1J7D|rcsb pdb:2C2V|rcsb pdb:3HCT|rcsb pdb:3HCU|rcsb pdb:3VON|rcsb pdb:3W31|rcsb pdb:4DHI|rcsb pdb:4DHJ|rcsb pdb:4DHZ|rcsb pdb:4IP3|rcsb pdb:4NR3|rcsb pdb:4NRG|rcsb pdb:4NRI|rcsb pdb:4ONL|rcsb pdb:4ONM|rcsb pdb:4ONN|rcsb pdb:4ORH|rcsb pdb:4TKP|rcsb pdb:4WHV|rcsb pdb:5AIT|rcsb pdb:5AIU|rcsb pdb:5EYA|rcsb pdb:5H7S|rcsb pdb:5VNZ|rcsb pdb:5VO0|rcsb pdb:5YWR|rcsb pdb:6D6I|rcsb pdb:6JKY|rcsb pdb:6KFP|rcsb pdb:6KG6|rcsb pdb:6KL4|rcsb pdb:6LP2|rcsb pdb:6P5B|rcsb pdb:6S53|reactome:R-HSA-168927|reactome:R-HSA-202424|reactome:R-HSA-2871837|reactome:R-HSA-445989|reactome:R-HSA-450302|reactome:R-HSA-450321|reactome:R-HSA-5607764|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-5696395|reactome:R-HSA-69473|reactome:R-HSA-8866654|reactome:R-HSA-9020702|reactome:R-HSA-937039|reactome:R-HSA-937041|reactome:R-HSA-9646399|reactome:R-HSA-975110|reactome:R-HSA-975144|reactome:R-HSA-983168|rcsb pdb:6ULH|rcsb pdb:6UMP|rcsb pdb:6UMS|rcsb pdb:7BBD|rcsb pdb:7BBF|rcsb pdb:7BXG|reactome:R-HSA-1169408|reactome:R-HSA-168638	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S2|caution:"UBE2N has been marked as the enzyme in this assay, although it is the UBE2N-UBE2V1 complex that has ubiquitinase (E3) activity. Neither UBE2N nor UBE2V1 have E2 or E3 activity on their own."|resulting-ptm:Q08DI6 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:Uj0YAf/t+AdYbMd6fgQ8hVKoP0w9913	rogid:dqdszHlq5FLPHC6UWX6uvkC6Yz89606	intact-crc:965FD8A45FFC52C0|rigid:Kvh/38tvuePo1OJbasMwmwG696c	false	-	his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q13404	uniprotkb:P22314	intact:EBI-1050671|uniprotkb:Q13403|uniprotkb:Q13532|uniprotkb:Q96H34|uniprotkb:Q9GZT0|uniprotkb:Q9GZW1|uniprotkb:Q9H4J3|uniprotkb:Q9H4J4|uniprotkb:Q9UKL1|uniprotkb:Q9UM48|uniprotkb:Q9UM49|uniprotkb:Q9UM50|uniprotkb:Q5TGE3|uniprotkb:E1P629|uniprotkb:Q5TGE0|ensembl:ENSP00000360739	intact:EBI-709688|uniprotkb:Q96E13|uniprotkb:Q5JRR8|ensembl:ENSP00000338413|ensembl:ENSP00000366568	psi-mi:ub2v1_human(display_long)|uniprotkb:CROC-1(gene name synonym)|uniprotkb:TRAF6-regulated IKK activator 1 beta Uev1A(gene name synonym)|uniprotkb:P/OKcl.19(orf name)|uniprotkb:UBE2V1(gene name)|psi-mi:UBE2V1(display_short)|uniprotkb:CROC1(gene name synonym)|uniprotkb:UBE2V(gene name synonym)|uniprotkb:UEV1(gene name synonym)	psi-mi:uba1_human(display_long)|uniprotkb:Ubiquitin-activating enzyme E1(gene name synonym)|uniprotkb:Protein A1S9(gene name synonym)|uniprotkb:UBA1(gene name)|psi-mi:UBA1(display_short)|uniprotkb:A1S9T(gene name synonym)|uniprotkb:UBE1(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9970493|imex:IM-22822-28	author-confidence:Z-score = 18.60|author-confidence:Z-score = 18.68	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001027459.1|refseq:NP_068823.2|refseq:NP_071887.1|refseq:NP_954595.1|refseq:NP_954673.1|refseq:NP_001244322.1|refseq:NP_001244323.1|refseq:NP_001244325.1|ensembl:ENSG00000244687(gene)|ensembl:ENST00000371674(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006282"(regulation of DNA repair)|go:"GO:0006301"(postreplication repair)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0030154"(cell differentiation)|go:"GO:0031371"(ubiquitin conjugating enzyme complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035370"(UBC13-UEV1A complex)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070534"(protein K63-linked ubiquitination)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|rcsb pdb:2A4D|rcsb pdb:2C2V|rcsb pdb:2HLW|rcsb pdb:6D6I|reactome:R-HSA-168638|reactome:R-HSA-168927|reactome:R-HSA-202424|reactome:R-HSA-2871837|reactome:R-HSA-445989|reactome:R-HSA-450302|reactome:R-HSA-450321|reactome:R-HSA-5607764|reactome:R-HSA-9020702|reactome:R-HSA-937039|reactome:R-HSA-937041|reactome:R-HSA-9646399|reactome:R-HSA-975110|reactome:R-HSA-975144|reactome:R-HSA-983168|dip:DIP-41911N	refseq:NP_003325.2|refseq:NP_695012.1|refseq:XP_016885269.1|refseq:XP_016885270.1|dip:DIP-33686N|ensembl:ENSG00000130985(gene)|ensembl:ENST00000335972(transcript)|ensembl:ENST00000377351(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0004839"(ubiquitin activating enzyme activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0032446"(protein modification by small protein conjugation)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000011(Ubiquitin-activating enzyme, E1)|interpro:IPR000594(UBA/THIF-type NAD/FAD binding fold)|interpro:IPR018074|interpro:IPR018075|interpro:IPR018965|interpro:IPR019572|interpro:IPR032418|interpro:IPR032420|interpro:IPR033127|interpro:IPR035985|interpro:IPR038252|interpro:IPR042063|interpro:IPR042302|interpro:IPR042449|mint:P22314|rcsb pdb:4P22|rcsb pdb:6DC6|reactome:R-HSA-8866652|reactome:R-HSA-983168	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S2|caution:"UBE2N has been marked as the enzyme in this assay, although it is the UBE2N-UBE2V1 complex that has ubiquitinase (E3) activity. Neither UBE2N nor UBE2V1 have E2 or E3 activity on their own."|resulting-ptm:Q05086 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:x95N7Dj2KIqu5gySX59xLmfthUg9606	rogid:q+vEeA0XLST0Zz173bmEt0dNbDE9606	intact-crc:260D7215B34A70C9|rigid:MluwgkIJ9/gM+mnaNuy3+nscEY4	false	his tag:?-?	his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q13404	uniprotkb:P61088	intact:EBI-1050671|uniprotkb:Q13403|uniprotkb:Q13532|uniprotkb:Q96H34|uniprotkb:Q9GZT0|uniprotkb:Q9GZW1|uniprotkb:Q9H4J3|uniprotkb:Q9H4J4|uniprotkb:Q9UKL1|uniprotkb:Q9UM48|uniprotkb:Q9UM49|uniprotkb:Q9UM50|uniprotkb:Q5TGE3|uniprotkb:E1P629|uniprotkb:Q5TGE0|ensembl:ENSP00000360739	intact:EBI-1052908|uniprotkb:Q16781|uniprotkb:Q53Y81|ensembl:ENSP00000316176	psi-mi:ub2v1_human(display_long)|uniprotkb:CROC-1(gene name synonym)|uniprotkb:TRAF6-regulated IKK activator 1 beta Uev1A(gene name synonym)|uniprotkb:P/OKcl.19(orf name)|uniprotkb:UBE2V1(gene name)|psi-mi:UBE2V1(display_short)|uniprotkb:CROC1(gene name synonym)|uniprotkb:UBE2V(gene name synonym)|uniprotkb:UEV1(gene name synonym)	psi-mi:ube2n_human(display_long)|uniprotkb:Ubiquitin-protein ligase N(gene name synonym)|uniprotkb:Ubiquitin carrier protein N(gene name synonym)|uniprotkb:Ubc13(gene name synonym)|uniprotkb:Bendless-like ubiquitin-conjugating enzyme(gene name synonym)|uniprotkb:UBE2N(gene name)|psi-mi:UBE2N(display_short)|uniprotkb:BLU(gene name synonym)|uniprotkb:UbcH13(gene name synonym)|uniprotkb:E2 ubiquitin-conjugating enzyme N(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9970493|imex:IM-22822-28	author-confidence:Z-score = 18.60|author-confidence:Z-score = 18.68	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001027459.1|refseq:NP_068823.2|refseq:NP_071887.1|refseq:NP_954595.1|refseq:NP_954673.1|refseq:NP_001244322.1|refseq:NP_001244323.1|refseq:NP_001244325.1|ensembl:ENSG00000244687(gene)|ensembl:ENST00000371674(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006282"(regulation of DNA repair)|go:"GO:0006301"(postreplication repair)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0030154"(cell differentiation)|go:"GO:0031371"(ubiquitin conjugating enzyme complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035370"(UBC13-UEV1A complex)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070534"(protein K63-linked ubiquitination)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|rcsb pdb:2A4D|rcsb pdb:2C2V|rcsb pdb:2HLW|rcsb pdb:6D6I|reactome:R-HSA-168638|reactome:R-HSA-168927|reactome:R-HSA-202424|reactome:R-HSA-2871837|reactome:R-HSA-445989|reactome:R-HSA-450302|reactome:R-HSA-450321|reactome:R-HSA-5607764|reactome:R-HSA-9020702|reactome:R-HSA-937039|reactome:R-HSA-937041|reactome:R-HSA-9646399|reactome:R-HSA-975110|reactome:R-HSA-975144|reactome:R-HSA-983168|dip:DIP-41911N	refseq:NP_003339.1|dip:DIP-29829N|ensembl:ENSG00000177889(gene)|ensembl:ENST00000318066(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000729"(DNA double-strand break processing)|go:"GO:0001650"(fibrillar center)|go:"GO:0003723"(RNA binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006282"(regulation of DNA repair)|go:"GO:0006301"(postreplication repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016574"(histone ubiquitination)|go:"GO:0031058"(positive regulation of histone modification)|go:"GO:0031372"(UBC13-MMS2 complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033182"(regulation of histone ubiquitination)|go:"GO:0035370"(UBC13-UEV1A complex)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0061631"(ubiquitin conjugating enzyme activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070534"(protein K63-linked ubiquitination)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|interpro:IPR023313|rcsb pdb:1J7D|rcsb pdb:2C2V|rcsb pdb:3HCT|rcsb pdb:3HCU|rcsb pdb:3VON|rcsb pdb:3W31|rcsb pdb:4DHI|rcsb pdb:4DHJ|rcsb pdb:4DHZ|rcsb pdb:4IP3|rcsb pdb:4NR3|rcsb pdb:4NRG|rcsb pdb:4NRI|rcsb pdb:4ONL|rcsb pdb:4ONM|rcsb pdb:4ONN|rcsb pdb:4ORH|rcsb pdb:4TKP|rcsb pdb:4WHV|rcsb pdb:5AIT|rcsb pdb:5AIU|rcsb pdb:5EYA|rcsb pdb:5H7S|rcsb pdb:5VNZ|rcsb pdb:5VO0|rcsb pdb:5YWR|rcsb pdb:6D6I|rcsb pdb:6JKY|rcsb pdb:6KFP|rcsb pdb:6KG6|rcsb pdb:6KL4|rcsb pdb:6LP2|rcsb pdb:6P5B|rcsb pdb:6S53|reactome:R-HSA-168927|reactome:R-HSA-202424|reactome:R-HSA-2871837|reactome:R-HSA-445989|reactome:R-HSA-450302|reactome:R-HSA-450321|reactome:R-HSA-5607764|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-5696395|reactome:R-HSA-69473|reactome:R-HSA-8866654|reactome:R-HSA-9020702|reactome:R-HSA-937039|reactome:R-HSA-937041|reactome:R-HSA-9646399|reactome:R-HSA-975110|reactome:R-HSA-975144|reactome:R-HSA-983168|rcsb pdb:6ULH|rcsb pdb:6UMP|rcsb pdb:6UMS|rcsb pdb:7BBD|rcsb pdb:7BBF|rcsb pdb:7BXG|reactome:R-HSA-1169408|reactome:R-HSA-168638	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S2|caution:"UBE2N has been marked as the enzyme in this assay, although it is the UBE2N-UBE2V1 complex that has ubiquitinase (E3) activity. Neither UBE2N nor UBE2V1 have E2 or E3 activity on their own."|resulting-ptm:Q05086 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:x95N7Dj2KIqu5gySX59xLmfthUg9606	rogid:dqdszHlq5FLPHC6UWX6uvkC6Yz89606	intact-crc:260D7215B34A70C9|rigid:MluwgkIJ9/gM+mnaNuy3+nscEY4	false	his tag:?-?	his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q13404	uniprotkb:Q05086	intact:EBI-1050671|uniprotkb:Q13403|uniprotkb:Q13532|uniprotkb:Q96H34|uniprotkb:Q9GZT0|uniprotkb:Q9GZW1|uniprotkb:Q9H4J3|uniprotkb:Q9H4J4|uniprotkb:Q9UKL1|uniprotkb:Q9UM48|uniprotkb:Q9UM49|uniprotkb:Q9UM50|uniprotkb:Q5TGE3|uniprotkb:E1P629|uniprotkb:Q5TGE0|ensembl:ENSP00000360739	intact:EBI-954357|ensembl:ENSP00000497594|uniprotkb:P78355|uniprotkb:Q93066|uniprotkb:Q9UEP4|uniprotkb:Q9UEP5|uniprotkb:Q9UEP6|uniprotkb:Q9UEP7|uniprotkb:Q9UEP8|uniprotkb:Q9UEP9|uniprotkb:A8K8Z9	psi-mi:ub2v1_human(display_long)|uniprotkb:CROC-1(gene name synonym)|uniprotkb:TRAF6-regulated IKK activator 1 beta Uev1A(gene name synonym)|uniprotkb:P/OKcl.19(orf name)|uniprotkb:UBE2V1(gene name)|psi-mi:UBE2V1(display_short)|uniprotkb:CROC1(gene name synonym)|uniprotkb:UBE2V(gene name synonym)|uniprotkb:UEV1(gene name synonym)	psi-mi:ube3a_human(display_long)|uniprotkb:E6AP ubiquitin-protein ligase(gene name synonym)|uniprotkb:Oncogenic protein-associated protein E6-AP(gene name synonym)|uniprotkb:Human papillomavirus E6-associated protein(gene name synonym)|uniprotkb:Renal carcinoma antigen NY-REN-54(gene name synonym)|uniprotkb:UBE3A(gene name)|psi-mi:UBE3A(display_short)|uniprotkb:E6AP(gene name synonym)|uniprotkb:EPVE6AP(gene name synonym)|uniprotkb:HPVE6A(gene name synonym)|uniprotkb:HECT-type ubiquitin transferase E3A(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9970493|imex:IM-22822-28	author-confidence:Z-score = 18.60|author-confidence:Z-score = 18.68	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001027459.1|refseq:NP_068823.2|refseq:NP_071887.1|refseq:NP_954595.1|refseq:NP_954673.1|refseq:NP_001244322.1|refseq:NP_001244323.1|refseq:NP_001244325.1|ensembl:ENSG00000244687(gene)|ensembl:ENST00000371674(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006282"(regulation of DNA repair)|go:"GO:0006301"(postreplication repair)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0030154"(cell differentiation)|go:"GO:0031371"(ubiquitin conjugating enzyme complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035370"(UBC13-UEV1A complex)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070534"(protein K63-linked ubiquitination)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|rcsb pdb:2A4D|rcsb pdb:2C2V|rcsb pdb:2HLW|rcsb pdb:6D6I|reactome:R-HSA-168638|reactome:R-HSA-168927|reactome:R-HSA-202424|reactome:R-HSA-2871837|reactome:R-HSA-445989|reactome:R-HSA-450302|reactome:R-HSA-450321|reactome:R-HSA-5607764|reactome:R-HSA-9020702|reactome:R-HSA-937039|reactome:R-HSA-937041|reactome:R-HSA-9646399|reactome:R-HSA-975110|reactome:R-HSA-975144|reactome:R-HSA-983168|dip:DIP-41911N	go:"GO:0050847"(progesterone receptor signaling pathway)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0060736"(prostate gland growth)|go:"GO:0061002"(negative regulation of dendritic spine morphogenesis)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0061743"(motor learning)|go:"GO:0070936"(protein K48-linked ubiquitination)|go:"GO:1905528"(positive regulation of Golgi lumen acidification)|go:"GO:1990416"(cellular response to brain-derived neurotrophic factor stimulus)|go:"GO:2000058"(regulation of ubiquitin-dependent protein catabolic process)|interpro:IPR000569(HECT)|interpro:IPR017134(Ubiquitin-protein ligase E6-AP)|interpro:IPR032353|interpro:IPR035983|interpro:IPR042556|mint:Q05086|rcsb pdb:1C4Z|rcsb pdb:1D5F|rcsb pdb:1EQX|rcsb pdb:2KR1|rcsb pdb:4GIZ|rcsb pdb:4XR8|rcsb pdb:6SJV|rcsb pdb:6SLM|rcsb pdb:6TGK|rcsb pdb:6U19|reactome:R-HSA-983168|ensembl:ENSG00000114062(gene)|ensembl:ENST00000650110(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0001541"(ovarian follicle development)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0006508"(proteolysis)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0007420"(brain development)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0030521"(androgen receptor signaling pathway)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032570"(response to progesterone)|go:"GO:0035037"(sperm entry)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0042220"(response to cocaine)|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048511"(rhythmic process)|refseq:NP_000453.2|refseq:NP_570853.1|refseq:NP_570854.1|refseq:XP_016878033.1|refseq:XP_016878034.1|refseq:XP_011520296.1|refseq:XP_011520297.1|refseq:XP_016878035.1|refseq:XP_016878036.1|refseq:XP_016878037.1|refseq:XP_016878038.1|refseq:XP_016878039.1|dip:DIP-6002N|refseq:XP_005268324.1|refseq:XP_005268325.1|refseq:XP_005268326.1|refseq:XP_005268327.1|refseq:XP_005268328.1|refseq:XP_006720738.1|refseq:XP_006720739.1|refseq:XP_016878040.1|refseq:XP_016878041.1|refseq:XP_016878042.1|refseq:XP_016878043.1|refseq:XP_016878044.1	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S2|caution:"UBE2N has been marked as the enzyme in this assay, although it is the UBE2N-UBE2V1 complex that has ubiquitinase (E3) activity. Neither UBE2N nor UBE2V1 have E2 or E3 activity on their own."|resulting-ptm:Q05086 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:x95N7Dj2KIqu5gySX59xLmfthUg9606	rogid:w9T67+NDlHSd1tR+FgcX3LI1zpQ9606	intact-crc:260D7215B34A70C9|rigid:MluwgkIJ9/gM+mnaNuy3+nscEY4	false	his tag:?-?	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q13404	uniprotkb:P22314	intact:EBI-1050671|uniprotkb:Q13403|uniprotkb:Q13532|uniprotkb:Q96H34|uniprotkb:Q9GZT0|uniprotkb:Q9GZW1|uniprotkb:Q9H4J3|uniprotkb:Q9H4J4|uniprotkb:Q9UKL1|uniprotkb:Q9UM48|uniprotkb:Q9UM49|uniprotkb:Q9UM50|uniprotkb:Q5TGE3|uniprotkb:E1P629|uniprotkb:Q5TGE0|ensembl:ENSP00000360739	intact:EBI-709688|uniprotkb:Q96E13|uniprotkb:Q5JRR8|ensembl:ENSP00000338413|ensembl:ENSP00000366568	psi-mi:ub2v1_human(display_long)|uniprotkb:CROC-1(gene name synonym)|uniprotkb:TRAF6-regulated IKK activator 1 beta Uev1A(gene name synonym)|uniprotkb:P/OKcl.19(orf name)|uniprotkb:UBE2V1(gene name)|psi-mi:UBE2V1(display_short)|uniprotkb:CROC1(gene name synonym)|uniprotkb:UBE2V(gene name synonym)|uniprotkb:UEV1(gene name synonym)	psi-mi:uba1_human(display_long)|uniprotkb:Ubiquitin-activating enzyme E1(gene name synonym)|uniprotkb:Protein A1S9(gene name synonym)|uniprotkb:UBA1(gene name)|psi-mi:UBA1(display_short)|uniprotkb:A1S9T(gene name synonym)|uniprotkb:UBE1(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9970599|imex:IM-22822-33	author-confidence:Z-score = 4.35	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001027459.1|refseq:NP_068823.2|refseq:NP_071887.1|refseq:NP_954595.1|refseq:NP_954673.1|refseq:NP_001244322.1|refseq:NP_001244323.1|refseq:NP_001244325.1|ensembl:ENSG00000244687(gene)|ensembl:ENST00000371674(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006282"(regulation of DNA repair)|go:"GO:0006301"(postreplication repair)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0030154"(cell differentiation)|go:"GO:0031371"(ubiquitin conjugating enzyme complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035370"(UBC13-UEV1A complex)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070534"(protein K63-linked ubiquitination)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|rcsb pdb:2A4D|rcsb pdb:2C2V|rcsb pdb:2HLW|rcsb pdb:6D6I|reactome:R-HSA-168638|reactome:R-HSA-168927|reactome:R-HSA-202424|reactome:R-HSA-2871837|reactome:R-HSA-445989|reactome:R-HSA-450302|reactome:R-HSA-450321|reactome:R-HSA-5607764|reactome:R-HSA-9020702|reactome:R-HSA-937039|reactome:R-HSA-937041|reactome:R-HSA-9646399|reactome:R-HSA-975110|reactome:R-HSA-975144|reactome:R-HSA-983168|dip:DIP-41911N	refseq:NP_003325.2|refseq:NP_695012.1|refseq:XP_016885269.1|refseq:XP_016885270.1|dip:DIP-33686N|ensembl:ENSG00000130985(gene)|ensembl:ENST00000335972(transcript)|ensembl:ENST00000377351(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0004839"(ubiquitin activating enzyme activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0032446"(protein modification by small protein conjugation)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000011(Ubiquitin-activating enzyme, E1)|interpro:IPR000594(UBA/THIF-type NAD/FAD binding fold)|interpro:IPR018074|interpro:IPR018075|interpro:IPR018965|interpro:IPR019572|interpro:IPR032418|interpro:IPR032420|interpro:IPR033127|interpro:IPR035985|interpro:IPR038252|interpro:IPR042063|interpro:IPR042302|interpro:IPR042449|mint:P22314|rcsb pdb:4P22|rcsb pdb:6DC6|reactome:R-HSA-8866652|reactome:R-HSA-983168	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S2|caution:"UBE2N has been marked as the enzyme in this assay, although it is the UBE2N-UBE2V1 complex that has ubiquitinase (E3) activity. Neither UBE2N nor UBE2V1 have E2 or E3 activity on their own."|resulting-ptm:Q16763 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:x95N7Dj2KIqu5gySX59xLmfthUg9606	rogid:q+vEeA0XLST0Zz173bmEt0dNbDE9606	intact-crc:E3965DC23FAD20F5|rigid:z5jYRYPMlh8MM439Ww8ZW5w5yrY	false	his tag:?-?	his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q13404	uniprotkb:P61088	intact:EBI-1050671|uniprotkb:Q13403|uniprotkb:Q13532|uniprotkb:Q96H34|uniprotkb:Q9GZT0|uniprotkb:Q9GZW1|uniprotkb:Q9H4J3|uniprotkb:Q9H4J4|uniprotkb:Q9UKL1|uniprotkb:Q9UM48|uniprotkb:Q9UM49|uniprotkb:Q9UM50|uniprotkb:Q5TGE3|uniprotkb:E1P629|uniprotkb:Q5TGE0|ensembl:ENSP00000360739	intact:EBI-1052908|uniprotkb:Q16781|uniprotkb:Q53Y81|ensembl:ENSP00000316176	psi-mi:ub2v1_human(display_long)|uniprotkb:CROC-1(gene name synonym)|uniprotkb:TRAF6-regulated IKK activator 1 beta Uev1A(gene name synonym)|uniprotkb:P/OKcl.19(orf name)|uniprotkb:UBE2V1(gene name)|psi-mi:UBE2V1(display_short)|uniprotkb:CROC1(gene name synonym)|uniprotkb:UBE2V(gene name synonym)|uniprotkb:UEV1(gene name synonym)	psi-mi:ube2n_human(display_long)|uniprotkb:Ubiquitin-protein ligase N(gene name synonym)|uniprotkb:Ubiquitin carrier protein N(gene name synonym)|uniprotkb:Ubc13(gene name synonym)|uniprotkb:Bendless-like ubiquitin-conjugating enzyme(gene name synonym)|uniprotkb:UBE2N(gene name)|psi-mi:UBE2N(display_short)|uniprotkb:BLU(gene name synonym)|uniprotkb:UbcH13(gene name synonym)|uniprotkb:E2 ubiquitin-conjugating enzyme N(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9970599|imex:IM-22822-33	author-confidence:Z-score = 4.35	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001027459.1|refseq:NP_068823.2|refseq:NP_071887.1|refseq:NP_954595.1|refseq:NP_954673.1|refseq:NP_001244322.1|refseq:NP_001244323.1|refseq:NP_001244325.1|ensembl:ENSG00000244687(gene)|ensembl:ENST00000371674(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006282"(regulation of DNA repair)|go:"GO:0006301"(postreplication repair)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0030154"(cell differentiation)|go:"GO:0031371"(ubiquitin conjugating enzyme complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035370"(UBC13-UEV1A complex)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070534"(protein K63-linked ubiquitination)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|rcsb pdb:2A4D|rcsb pdb:2C2V|rcsb pdb:2HLW|rcsb pdb:6D6I|reactome:R-HSA-168638|reactome:R-HSA-168927|reactome:R-HSA-202424|reactome:R-HSA-2871837|reactome:R-HSA-445989|reactome:R-HSA-450302|reactome:R-HSA-450321|reactome:R-HSA-5607764|reactome:R-HSA-9020702|reactome:R-HSA-937039|reactome:R-HSA-937041|reactome:R-HSA-9646399|reactome:R-HSA-975110|reactome:R-HSA-975144|reactome:R-HSA-983168|dip:DIP-41911N	refseq:NP_003339.1|dip:DIP-29829N|ensembl:ENSG00000177889(gene)|ensembl:ENST00000318066(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000729"(DNA double-strand break processing)|go:"GO:0001650"(fibrillar center)|go:"GO:0003723"(RNA binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006282"(regulation of DNA repair)|go:"GO:0006301"(postreplication repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016574"(histone ubiquitination)|go:"GO:0031058"(positive regulation of histone modification)|go:"GO:0031372"(UBC13-MMS2 complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033182"(regulation of histone ubiquitination)|go:"GO:0035370"(UBC13-UEV1A complex)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0061631"(ubiquitin conjugating enzyme activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070534"(protein K63-linked ubiquitination)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|interpro:IPR023313|rcsb pdb:1J7D|rcsb pdb:2C2V|rcsb pdb:3HCT|rcsb pdb:3HCU|rcsb pdb:3VON|rcsb pdb:3W31|rcsb pdb:4DHI|rcsb pdb:4DHJ|rcsb pdb:4DHZ|rcsb pdb:4IP3|rcsb pdb:4NR3|rcsb pdb:4NRG|rcsb pdb:4NRI|rcsb pdb:4ONL|rcsb pdb:4ONM|rcsb pdb:4ONN|rcsb pdb:4ORH|rcsb pdb:4TKP|rcsb pdb:4WHV|rcsb pdb:5AIT|rcsb pdb:5AIU|rcsb pdb:5EYA|rcsb pdb:5H7S|rcsb pdb:5VNZ|rcsb pdb:5VO0|rcsb pdb:5YWR|rcsb pdb:6D6I|rcsb pdb:6JKY|rcsb pdb:6KFP|rcsb pdb:6KG6|rcsb pdb:6KL4|rcsb pdb:6LP2|rcsb pdb:6P5B|rcsb pdb:6S53|reactome:R-HSA-168927|reactome:R-HSA-202424|reactome:R-HSA-2871837|reactome:R-HSA-445989|reactome:R-HSA-450302|reactome:R-HSA-450321|reactome:R-HSA-5607764|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-5696395|reactome:R-HSA-69473|reactome:R-HSA-8866654|reactome:R-HSA-9020702|reactome:R-HSA-937039|reactome:R-HSA-937041|reactome:R-HSA-9646399|reactome:R-HSA-975110|reactome:R-HSA-975144|reactome:R-HSA-983168|rcsb pdb:6ULH|rcsb pdb:6UMP|rcsb pdb:6UMS|rcsb pdb:7BBD|rcsb pdb:7BBF|rcsb pdb:7BXG|reactome:R-HSA-1169408|reactome:R-HSA-168638	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S2|caution:"UBE2N has been marked as the enzyme in this assay, although it is the UBE2N-UBE2V1 complex that has ubiquitinase (E3) activity. Neither UBE2N nor UBE2V1 have E2 or E3 activity on their own."|resulting-ptm:Q16763 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:x95N7Dj2KIqu5gySX59xLmfthUg9606	rogid:dqdszHlq5FLPHC6UWX6uvkC6Yz89606	intact-crc:E3965DC23FAD20F5|rigid:z5jYRYPMlh8MM439Ww8ZW5w5yrY	false	his tag:?-?	his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q13404	uniprotkb:Q16763	intact:EBI-1050671|uniprotkb:Q13403|uniprotkb:Q13532|uniprotkb:Q96H34|uniprotkb:Q9GZT0|uniprotkb:Q9GZW1|uniprotkb:Q9H4J3|uniprotkb:Q9H4J4|uniprotkb:Q9UKL1|uniprotkb:Q9UM48|uniprotkb:Q9UM49|uniprotkb:Q9UM50|uniprotkb:Q5TGE3|uniprotkb:E1P629|uniprotkb:Q5TGE0|ensembl:ENSP00000360739	intact:EBI-2339823|uniprotkb:Q9BTC1|ensembl:ENSP00000264552	psi-mi:ub2v1_human(display_long)|uniprotkb:CROC-1(gene name synonym)|uniprotkb:TRAF6-regulated IKK activator 1 beta Uev1A(gene name synonym)|uniprotkb:P/OKcl.19(orf name)|uniprotkb:UBE2V1(gene name)|psi-mi:UBE2V1(display_short)|uniprotkb:CROC1(gene name synonym)|uniprotkb:UBE2V(gene name synonym)|uniprotkb:UEV1(gene name synonym)	psi-mi:ube2s_human(display_long)|uniprotkb:UBE2S(gene name)|psi-mi:UBE2S(display_short)|uniprotkb:E2EPF(gene name synonym)|uniprotkb:Ubiquitin-protein ligase S(gene name synonym)|uniprotkb:Ubiquitin carrier protein S(gene name synonym)|uniprotkb:Ubiquitin-conjugating enzyme E2-24 kDa(gene name synonym)|uniprotkb:Ubiquitin-conjugating enzyme E2-EPF5(gene name synonym)|uniprotkb:OK/SW-cl.73(orf name)|uniprotkb:E2-EPF(gene name synonym)|uniprotkb:E2 ubiquitin-conjugating enzyme S(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9970599|imex:IM-22822-33	author-confidence:Z-score = 4.35	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001027459.1|refseq:NP_068823.2|refseq:NP_071887.1|refseq:NP_954595.1|refseq:NP_954673.1|refseq:NP_001244322.1|refseq:NP_001244323.1|refseq:NP_001244325.1|ensembl:ENSG00000244687(gene)|ensembl:ENST00000371674(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006282"(regulation of DNA repair)|go:"GO:0006301"(postreplication repair)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0030154"(cell differentiation)|go:"GO:0031371"(ubiquitin conjugating enzyme complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035370"(UBC13-UEV1A complex)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070534"(protein K63-linked ubiquitination)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|rcsb pdb:2A4D|rcsb pdb:2C2V|rcsb pdb:2HLW|rcsb pdb:6D6I|reactome:R-HSA-168638|reactome:R-HSA-168927|reactome:R-HSA-202424|reactome:R-HSA-2871837|reactome:R-HSA-445989|reactome:R-HSA-450302|reactome:R-HSA-450321|reactome:R-HSA-5607764|reactome:R-HSA-9020702|reactome:R-HSA-937039|reactome:R-HSA-937041|reactome:R-HSA-9646399|reactome:R-HSA-975110|reactome:R-HSA-975144|reactome:R-HSA-983168|dip:DIP-41911N	refseq:NP_055316.2|dip:DIP-52784N|ensembl:ENSG00000108106(gene)|ensembl:ENST00000264552(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005680"(anaphase-promoting complex)|go:"GO:0005829"(cytosol)|go:"GO:0006464"(cellular protein modification process)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0010458"(exit from mitosis)|go:"GO:0010994"(free ubiquitin chain polymerization)|go:"GO:0010997"(anaphase-promoting complex binding)|go:"GO:0031145"(anaphase-promoting complex-dependent catabolic process)|go:"GO:0035519"(protein K29-linked ubiquitination)|go:"GO:0044314"(protein K27-linked ubiquitination)|go:"GO:0051301"(cell division)|go:"GO:0061631"(ubiquitin conjugating enzyme activity)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0070979"(protein K11-linked ubiquitination)|go:"GO:0085020"(protein K6-linked ubiquitination)|go:"GO:1904668"(positive regulation of ubiquitin protein ligase activity)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|interpro:IPR023313|rcsb pdb:1ZDN|rcsb pdb:5BNB|rcsb pdb:5L9T|rcsb pdb:6QH3|rcsb pdb:6QHK|rcsb pdb:6S96|rcsb pdb:6S98|reactome:R-HSA-141430|reactome:R-HSA-174048|reactome:R-HSA-174084|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-176407|reactome:R-HSA-176408|reactome:R-HSA-176409|reactome:R-HSA-176412|reactome:R-HSA-179409|reactome:R-HSA-2467813|reactome:R-HSA-2559582|reactome:R-HSA-69017|reactome:R-HSA-8853884|reactome:R-HSA-8866652|reactome:R-HSA-9687136|reactome:R-HSA-983168	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S2|caution:"UBE2N has been marked as the enzyme in this assay, although it is the UBE2N-UBE2V1 complex that has ubiquitinase (E3) activity. Neither UBE2N nor UBE2V1 have E2 or E3 activity on their own."|resulting-ptm:Q16763 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:x95N7Dj2KIqu5gySX59xLmfthUg9606	rogid:PiLqBXIHRM8f6hlUXU6PkI3xNtM9606	intact-crc:E3965DC23FAD20F5|rigid:z5jYRYPMlh8MM439Ww8ZW5w5yrY	false	his tag:?-?	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q15067	uniprotkb:Q13404	intact:EBI-3048535|ensembl:ENSP00000301608|uniprotkb:Q15101|uniprotkb:Q16131|uniprotkb:Q9UD31|uniprotkb:Q12863|uniprotkb:Q15068|uniprotkb:Q7Z3W5|uniprotkb:A8K6X8|uniprotkb:A8KAA0|uniprotkb:B4DK61|uniprotkb:F5GYQ8	intact:EBI-1050671|uniprotkb:Q13403|uniprotkb:Q13532|uniprotkb:Q96H34|uniprotkb:Q9GZT0|uniprotkb:Q9GZW1|uniprotkb:Q9H4J3|uniprotkb:Q9H4J4|uniprotkb:Q9UKL1|uniprotkb:Q9UM48|uniprotkb:Q9UM49|uniprotkb:Q9UM50|uniprotkb:Q5TGE3|uniprotkb:E1P629|uniprotkb:Q5TGE0|ensembl:ENSP00000360739	psi-mi:acox1_human(display_long)|uniprotkb:ACOX1(gene name)|psi-mi:ACOX1(display_short)|uniprotkb:ACOX(gene name synonym)|uniprotkb:Palmitoyl-CoA oxidase(gene name synonym)|uniprotkb:Straight-chain acyl-CoA oxidase(gene name synonym)	psi-mi:ub2v1_human(display_long)|uniprotkb:CROC-1(gene name synonym)|uniprotkb:TRAF6-regulated IKK activator 1 beta Uev1A(gene name synonym)|uniprotkb:P/OKcl.19(orf name)|uniprotkb:UBE2V1(gene name)|psi-mi:UBE2V1(display_short)|uniprotkb:CROC1(gene name synonym)|uniprotkb:UBE2V(gene name synonym)|uniprotkb:UEV1(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9970578|imex:IM-22822-32	author-confidence:Z-score = 6.47	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000161533(gene)|ensembl:ENST00000301608(transcript)|go:"GO:0000038"(very long-chain fatty acid metabolic process)|go:"GO:0003997"(acyl-CoA oxidase activity)|go:"GO:0005504"(fatty acid binding)|go:"GO:0005777"(peroxisome)|go:"GO:0005778"(peroxisomal membrane)|go:"GO:0005782"(peroxisomal matrix)|go:"GO:0005829"(cytosol)|go:"GO:0006091"(generation of precursor metabolites and energy)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0006693"(prostaglandin metabolic process)|go:"GO:0007283"(spermatogenesis)|go:"GO:0009062"(fatty acid catabolic process)|go:"GO:0016020"(membrane)|go:"GO:0016401"(palmitoyl-CoA oxidase activity)|go:"GO:0016559"(peroxisome fission)|go:"GO:0019395"(fatty acid oxidation)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0033540"(fatty acid beta-oxidation using acyl-CoA oxidase)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0050660"(flavin adenine dinucleotide binding)|go:"GO:0050665"(hydrogen peroxide biosynthetic process)|go:"GO:0055088"(lipid homeostasis)|go:"GO:0071949"(FAD binding)|go:"GO:0140493"(very long-chain fatty acid beta-oxidation)|interpro:IPR002655(Acyl-CoA oxidase, C-terminal)|interpro:IPR006091(Acyl-CoA dehydrogenase/oxidase, central region)|interpro:IPR012258(Acyl-CoA oxidase)|interpro:IPR029320|interpro:IPR009100(Acyl-CoA dehydrogenase/oxidase, middle and N-terminal)|interpro:IPR034171|interpro:IPR036250|interpro:IPR037069|reactome:R-HSA-1989781|reactome:R-HSA-2046106|reactome:R-HSA-390247|reactome:R-HSA-9033241|reactome:R-HSA-9033500|refseq:NP_001171968.1|refseq:NP_004026.2|refseq:NP_009223.2	refseq:NP_001027459.1|refseq:NP_068823.2|refseq:NP_071887.1|refseq:NP_954595.1|refseq:NP_954673.1|refseq:NP_001244322.1|refseq:NP_001244323.1|refseq:NP_001244325.1|ensembl:ENSG00000244687(gene)|ensembl:ENST00000371674(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006282"(regulation of DNA repair)|go:"GO:0006301"(postreplication repair)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0030154"(cell differentiation)|go:"GO:0031371"(ubiquitin conjugating enzyme complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035370"(UBC13-UEV1A complex)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070534"(protein K63-linked ubiquitination)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|rcsb pdb:2A4D|rcsb pdb:2C2V|rcsb pdb:2HLW|rcsb pdb:6D6I|reactome:R-HSA-168638|reactome:R-HSA-168927|reactome:R-HSA-202424|reactome:R-HSA-2871837|reactome:R-HSA-445989|reactome:R-HSA-450302|reactome:R-HSA-450321|reactome:R-HSA-5607764|reactome:R-HSA-9020702|reactome:R-HSA-937039|reactome:R-HSA-937041|reactome:R-HSA-9646399|reactome:R-HSA-975110|reactome:R-HSA-975144|reactome:R-HSA-983168|dip:DIP-41911N	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S2|caution:"UBE2N has been marked as the enzyme in this assay, although it is the UBE2N-UBE2V1 complex that has ubiquitinase (E3) activity. Neither UBE2N nor UBE2V1 have E2 or E3 activity on their own."|resulting-ptm:Q15067 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:nmFzdfUulW0CSpRLqXcetLzLvwk9606	rogid:x95N7Dj2KIqu5gySX59xLmfthUg9606	intact-crc:8EEDFF965DFAA6AE|rigid:xi7lHaDAtNkIOUJSXyZEX9pksyw	false	-	his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q15067	uniprotkb:P22314	intact:EBI-3048535|ensembl:ENSP00000301608|uniprotkb:Q15101|uniprotkb:Q16131|uniprotkb:Q9UD31|uniprotkb:Q12863|uniprotkb:Q15068|uniprotkb:Q7Z3W5|uniprotkb:A8K6X8|uniprotkb:A8KAA0|uniprotkb:B4DK61|uniprotkb:F5GYQ8	intact:EBI-709688|uniprotkb:Q96E13|uniprotkb:Q5JRR8|ensembl:ENSP00000338413|ensembl:ENSP00000366568	psi-mi:acox1_human(display_long)|uniprotkb:ACOX1(gene name)|psi-mi:ACOX1(display_short)|uniprotkb:ACOX(gene name synonym)|uniprotkb:Palmitoyl-CoA oxidase(gene name synonym)|uniprotkb:Straight-chain acyl-CoA oxidase(gene name synonym)	psi-mi:uba1_human(display_long)|uniprotkb:Ubiquitin-activating enzyme E1(gene name synonym)|uniprotkb:Protein A1S9(gene name synonym)|uniprotkb:UBA1(gene name)|psi-mi:UBA1(display_short)|uniprotkb:A1S9T(gene name synonym)|uniprotkb:UBE1(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9970578|imex:IM-22822-32	author-confidence:Z-score = 6.47	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000161533(gene)|ensembl:ENST00000301608(transcript)|go:"GO:0000038"(very long-chain fatty acid metabolic process)|go:"GO:0003997"(acyl-CoA oxidase activity)|go:"GO:0005504"(fatty acid binding)|go:"GO:0005777"(peroxisome)|go:"GO:0005778"(peroxisomal membrane)|go:"GO:0005782"(peroxisomal matrix)|go:"GO:0005829"(cytosol)|go:"GO:0006091"(generation of precursor metabolites and energy)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0006693"(prostaglandin metabolic process)|go:"GO:0007283"(spermatogenesis)|go:"GO:0009062"(fatty acid catabolic process)|go:"GO:0016020"(membrane)|go:"GO:0016401"(palmitoyl-CoA oxidase activity)|go:"GO:0016559"(peroxisome fission)|go:"GO:0019395"(fatty acid oxidation)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0033540"(fatty acid beta-oxidation using acyl-CoA oxidase)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0050660"(flavin adenine dinucleotide binding)|go:"GO:0050665"(hydrogen peroxide biosynthetic process)|go:"GO:0055088"(lipid homeostasis)|go:"GO:0071949"(FAD binding)|go:"GO:0140493"(very long-chain fatty acid beta-oxidation)|interpro:IPR002655(Acyl-CoA oxidase, C-terminal)|interpro:IPR006091(Acyl-CoA dehydrogenase/oxidase, central region)|interpro:IPR012258(Acyl-CoA oxidase)|interpro:IPR029320|interpro:IPR009100(Acyl-CoA dehydrogenase/oxidase, middle and N-terminal)|interpro:IPR034171|interpro:IPR036250|interpro:IPR037069|reactome:R-HSA-1989781|reactome:R-HSA-2046106|reactome:R-HSA-390247|reactome:R-HSA-9033241|reactome:R-HSA-9033500|refseq:NP_001171968.1|refseq:NP_004026.2|refseq:NP_009223.2	refseq:NP_003325.2|refseq:NP_695012.1|refseq:XP_016885269.1|refseq:XP_016885270.1|dip:DIP-33686N|ensembl:ENSG00000130985(gene)|ensembl:ENST00000335972(transcript)|ensembl:ENST00000377351(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0004839"(ubiquitin activating enzyme activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0032446"(protein modification by small protein conjugation)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000011(Ubiquitin-activating enzyme, E1)|interpro:IPR000594(UBA/THIF-type NAD/FAD binding fold)|interpro:IPR018074|interpro:IPR018075|interpro:IPR018965|interpro:IPR019572|interpro:IPR032418|interpro:IPR032420|interpro:IPR033127|interpro:IPR035985|interpro:IPR038252|interpro:IPR042063|interpro:IPR042302|interpro:IPR042449|mint:P22314|rcsb pdb:4P22|rcsb pdb:6DC6|reactome:R-HSA-8866652|reactome:R-HSA-983168	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S2|caution:"UBE2N has been marked as the enzyme in this assay, although it is the UBE2N-UBE2V1 complex that has ubiquitinase (E3) activity. Neither UBE2N nor UBE2V1 have E2 or E3 activity on their own."|resulting-ptm:Q15067 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:nmFzdfUulW0CSpRLqXcetLzLvwk9606	rogid:q+vEeA0XLST0Zz173bmEt0dNbDE9606	intact-crc:8EEDFF965DFAA6AE|rigid:xi7lHaDAtNkIOUJSXyZEX9pksyw	false	-	his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q15067	uniprotkb:P61088	intact:EBI-3048535|ensembl:ENSP00000301608|uniprotkb:Q15101|uniprotkb:Q16131|uniprotkb:Q9UD31|uniprotkb:Q12863|uniprotkb:Q15068|uniprotkb:Q7Z3W5|uniprotkb:A8K6X8|uniprotkb:A8KAA0|uniprotkb:B4DK61|uniprotkb:F5GYQ8	intact:EBI-1052908|uniprotkb:Q16781|uniprotkb:Q53Y81|ensembl:ENSP00000316176	psi-mi:acox1_human(display_long)|uniprotkb:ACOX1(gene name)|psi-mi:ACOX1(display_short)|uniprotkb:ACOX(gene name synonym)|uniprotkb:Palmitoyl-CoA oxidase(gene name synonym)|uniprotkb:Straight-chain acyl-CoA oxidase(gene name synonym)	psi-mi:ube2n_human(display_long)|uniprotkb:Ubiquitin-protein ligase N(gene name synonym)|uniprotkb:Ubiquitin carrier protein N(gene name synonym)|uniprotkb:Ubc13(gene name synonym)|uniprotkb:Bendless-like ubiquitin-conjugating enzyme(gene name synonym)|uniprotkb:UBE2N(gene name)|psi-mi:UBE2N(display_short)|uniprotkb:BLU(gene name synonym)|uniprotkb:UbcH13(gene name synonym)|uniprotkb:E2 ubiquitin-conjugating enzyme N(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9970578|imex:IM-22822-32	author-confidence:Z-score = 6.47	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000161533(gene)|ensembl:ENST00000301608(transcript)|go:"GO:0000038"(very long-chain fatty acid metabolic process)|go:"GO:0003997"(acyl-CoA oxidase activity)|go:"GO:0005504"(fatty acid binding)|go:"GO:0005777"(peroxisome)|go:"GO:0005778"(peroxisomal membrane)|go:"GO:0005782"(peroxisomal matrix)|go:"GO:0005829"(cytosol)|go:"GO:0006091"(generation of precursor metabolites and energy)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0006693"(prostaglandin metabolic process)|go:"GO:0007283"(spermatogenesis)|go:"GO:0009062"(fatty acid catabolic process)|go:"GO:0016020"(membrane)|go:"GO:0016401"(palmitoyl-CoA oxidase activity)|go:"GO:0016559"(peroxisome fission)|go:"GO:0019395"(fatty acid oxidation)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0033540"(fatty acid beta-oxidation using acyl-CoA oxidase)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0050660"(flavin adenine dinucleotide binding)|go:"GO:0050665"(hydrogen peroxide biosynthetic process)|go:"GO:0055088"(lipid homeostasis)|go:"GO:0071949"(FAD binding)|go:"GO:0140493"(very long-chain fatty acid beta-oxidation)|interpro:IPR002655(Acyl-CoA oxidase, C-terminal)|interpro:IPR006091(Acyl-CoA dehydrogenase/oxidase, central region)|interpro:IPR012258(Acyl-CoA oxidase)|interpro:IPR029320|interpro:IPR009100(Acyl-CoA dehydrogenase/oxidase, middle and N-terminal)|interpro:IPR034171|interpro:IPR036250|interpro:IPR037069|reactome:R-HSA-1989781|reactome:R-HSA-2046106|reactome:R-HSA-390247|reactome:R-HSA-9033241|reactome:R-HSA-9033500|refseq:NP_001171968.1|refseq:NP_004026.2|refseq:NP_009223.2	refseq:NP_003339.1|dip:DIP-29829N|ensembl:ENSG00000177889(gene)|ensembl:ENST00000318066(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000729"(DNA double-strand break processing)|go:"GO:0001650"(fibrillar center)|go:"GO:0003723"(RNA binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006282"(regulation of DNA repair)|go:"GO:0006301"(postreplication repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016574"(histone ubiquitination)|go:"GO:0031058"(positive regulation of histone modification)|go:"GO:0031372"(UBC13-MMS2 complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033182"(regulation of histone ubiquitination)|go:"GO:0035370"(UBC13-UEV1A complex)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0061631"(ubiquitin conjugating enzyme activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070534"(protein K63-linked ubiquitination)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|interpro:IPR023313|rcsb pdb:1J7D|rcsb pdb:2C2V|rcsb pdb:3HCT|rcsb pdb:3HCU|rcsb pdb:3VON|rcsb pdb:3W31|rcsb pdb:4DHI|rcsb pdb:4DHJ|rcsb pdb:4DHZ|rcsb pdb:4IP3|rcsb pdb:4NR3|rcsb pdb:4NRG|rcsb pdb:4NRI|rcsb pdb:4ONL|rcsb pdb:4ONM|rcsb pdb:4ONN|rcsb pdb:4ORH|rcsb pdb:4TKP|rcsb pdb:4WHV|rcsb pdb:5AIT|rcsb pdb:5AIU|rcsb pdb:5EYA|rcsb pdb:5H7S|rcsb pdb:5VNZ|rcsb pdb:5VO0|rcsb pdb:5YWR|rcsb pdb:6D6I|rcsb pdb:6JKY|rcsb pdb:6KFP|rcsb pdb:6KG6|rcsb pdb:6KL4|rcsb pdb:6LP2|rcsb pdb:6P5B|rcsb pdb:6S53|reactome:R-HSA-168927|reactome:R-HSA-202424|reactome:R-HSA-2871837|reactome:R-HSA-445989|reactome:R-HSA-450302|reactome:R-HSA-450321|reactome:R-HSA-5607764|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-5696395|reactome:R-HSA-69473|reactome:R-HSA-8866654|reactome:R-HSA-9020702|reactome:R-HSA-937039|reactome:R-HSA-937041|reactome:R-HSA-9646399|reactome:R-HSA-975110|reactome:R-HSA-975144|reactome:R-HSA-983168|rcsb pdb:6ULH|rcsb pdb:6UMP|rcsb pdb:6UMS|rcsb pdb:7BBD|rcsb pdb:7BBF|rcsb pdb:7BXG|reactome:R-HSA-1169408|reactome:R-HSA-168638	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S2|caution:"UBE2N has been marked as the enzyme in this assay, although it is the UBE2N-UBE2V1 complex that has ubiquitinase (E3) activity. Neither UBE2N nor UBE2V1 have E2 or E3 activity on their own."|resulting-ptm:Q15067 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:nmFzdfUulW0CSpRLqXcetLzLvwk9606	rogid:dqdszHlq5FLPHC6UWX6uvkC6Yz89606	intact-crc:8EEDFF965DFAA6AE|rigid:xi7lHaDAtNkIOUJSXyZEX9pksyw	false	-	his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q13489	uniprotkb:Q13404	intact:EBI-517709|uniprotkb:Q16628|uniprotkb:Q9HC27|uniprotkb:Q9UP46|ensembl:ENSP00000263464|ensembl:ENSP00000432907|ensembl:ENSP00000481903|ensembl:ENSP00000501119	intact:EBI-1050671|uniprotkb:Q13403|uniprotkb:Q13532|uniprotkb:Q96H34|uniprotkb:Q9GZT0|uniprotkb:Q9GZW1|uniprotkb:Q9H4J3|uniprotkb:Q9H4J4|uniprotkb:Q9UKL1|uniprotkb:Q9UM48|uniprotkb:Q9UM49|uniprotkb:Q9UM50|uniprotkb:Q5TGE3|uniprotkb:E1P629|uniprotkb:Q5TGE0|ensembl:ENSP00000360739	psi-mi:birc3_human(display_long)|uniprotkb:Inhibitor of apoptosis protein 1(gene name synonym)|uniprotkb:TNFR2-TRAF-signaling complex protein 1(gene name synonym)|uniprotkb:IAP homolog C(gene name synonym)|uniprotkb:Apoptosis inhibitor 2(gene name synonym)|uniprotkb:RING finger protein 49(gene name synonym)|uniprotkb:BIRC3(gene name)|psi-mi:BIRC3(display_short)|uniprotkb:API2(gene name synonym)|uniprotkb:MIHC(gene name synonym)|uniprotkb:RNF49(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase BIRC3(gene name synonym)|uniprotkb:Cellular inhibitor of apoptosis 2(gene name synonym)	psi-mi:ub2v1_human(display_long)|uniprotkb:CROC-1(gene name synonym)|uniprotkb:TRAF6-regulated IKK activator 1 beta Uev1A(gene name synonym)|uniprotkb:P/OKcl.19(orf name)|uniprotkb:UBE2V1(gene name)|psi-mi:UBE2V1(display_short)|uniprotkb:CROC1(gene name synonym)|uniprotkb:UBE2V(gene name synonym)|uniprotkb:UEV1(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9970557|imex:IM-22822-31	author-confidence:Z-score = 18.64	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000023445(gene)|ensembl:ENST00000263464(transcript)|ensembl:ENST00000526421(transcript)|ensembl:ENST00000532808(transcript)|ensembl:ENST00000615299(transcript)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0007283"(spermatogenesis)|go:"GO:0016740"(transferase activity)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034121"(regulation of toll-like receptor signaling pathway)|go:"GO:0038061"(NIK/NF-kappaB signaling)|go:"GO:0039535"(regulation of RIG-I signaling pathway)|go:"GO:0042981"(regulation of apoptotic process)|refseq:NP_001156.1|refseq:NP_892007.1|refseq:XP_016873132.1|dip:DIP-33720N|go:"GO:0043027"(cysteine-type endopeptidase inhibitor activity involved in apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045088"(regulation of innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0046872"(metal ion binding)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060544"(regulation of necroptotic process)|go:"GO:0060546"(negative regulation of necroptotic process)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070424"(regulation of nucleotide-binding oligomerization domain containing signaling pathway)|go:"GO:2000116"(regulation of cysteine-type endopeptidase activity)|interpro:IPR001315(Caspase Recruitment)|interpro:IPR001370(Proteinase inhibitor I32, inhibitor of apoptosis)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR011029(DEATH-like)|rcsb pdb:2UVL|rcsb pdb:3EB5|rcsb pdb:3EB6|rcsb pdb:3M0A|rcsb pdb:3M0D|reactome:R-HSA-168638|reactome:R-HSA-168927|reactome:R-HSA-5213460|reactome:R-HSA-5357905|reactome:R-HSA-5357956|reactome:R-HSA-5668541|reactome:R-HSA-5675482|reactome:R-HSA-5676594|reactome:R-HSA-5689880|reactome:R-HSA-937041	refseq:NP_001027459.1|refseq:NP_068823.2|refseq:NP_071887.1|refseq:NP_954595.1|refseq:NP_954673.1|refseq:NP_001244322.1|refseq:NP_001244323.1|refseq:NP_001244325.1|ensembl:ENSG00000244687(gene)|ensembl:ENST00000371674(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006282"(regulation of DNA repair)|go:"GO:0006301"(postreplication repair)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0030154"(cell differentiation)|go:"GO:0031371"(ubiquitin conjugating enzyme complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035370"(UBC13-UEV1A complex)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070534"(protein K63-linked ubiquitination)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|rcsb pdb:2A4D|rcsb pdb:2C2V|rcsb pdb:2HLW|rcsb pdb:6D6I|reactome:R-HSA-168638|reactome:R-HSA-168927|reactome:R-HSA-202424|reactome:R-HSA-2871837|reactome:R-HSA-445989|reactome:R-HSA-450302|reactome:R-HSA-450321|reactome:R-HSA-5607764|reactome:R-HSA-9020702|reactome:R-HSA-937039|reactome:R-HSA-937041|reactome:R-HSA-9646399|reactome:R-HSA-975110|reactome:R-HSA-975144|reactome:R-HSA-983168|dip:DIP-41911N	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S2|caution:"UBE2N has been marked as the enzyme in this assay, although it is the UBE2N-UBE2V1 complex that has ubiquitinase (E3) activity. Neither UBE2N nor UBE2V1 have E2 or E3 activity on their own."|resulting-ptm:Q13489 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:TBTCMhQ/t2ZIBvxbWIiiv4oo9bc9606	rogid:x95N7Dj2KIqu5gySX59xLmfthUg9606	intact-crc:17101F1191F49B3C|rigid:kdne4JjpwsV3jb+1E0Z4b/K7tWg	false	-	his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q13489	uniprotkb:P22314	intact:EBI-517709|uniprotkb:Q16628|uniprotkb:Q9HC27|uniprotkb:Q9UP46|ensembl:ENSP00000263464|ensembl:ENSP00000432907|ensembl:ENSP00000481903|ensembl:ENSP00000501119	intact:EBI-709688|uniprotkb:Q96E13|uniprotkb:Q5JRR8|ensembl:ENSP00000338413|ensembl:ENSP00000366568	psi-mi:birc3_human(display_long)|uniprotkb:Inhibitor of apoptosis protein 1(gene name synonym)|uniprotkb:TNFR2-TRAF-signaling complex protein 1(gene name synonym)|uniprotkb:IAP homolog C(gene name synonym)|uniprotkb:Apoptosis inhibitor 2(gene name synonym)|uniprotkb:RING finger protein 49(gene name synonym)|uniprotkb:BIRC3(gene name)|psi-mi:BIRC3(display_short)|uniprotkb:API2(gene name synonym)|uniprotkb:MIHC(gene name synonym)|uniprotkb:RNF49(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase BIRC3(gene name synonym)|uniprotkb:Cellular inhibitor of apoptosis 2(gene name synonym)	psi-mi:uba1_human(display_long)|uniprotkb:Ubiquitin-activating enzyme E1(gene name synonym)|uniprotkb:Protein A1S9(gene name synonym)|uniprotkb:UBA1(gene name)|psi-mi:UBA1(display_short)|uniprotkb:A1S9T(gene name synonym)|uniprotkb:UBE1(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9970557|imex:IM-22822-31	author-confidence:Z-score = 18.64	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000023445(gene)|ensembl:ENST00000263464(transcript)|ensembl:ENST00000526421(transcript)|ensembl:ENST00000532808(transcript)|ensembl:ENST00000615299(transcript)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0007283"(spermatogenesis)|go:"GO:0016740"(transferase activity)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034121"(regulation of toll-like receptor signaling pathway)|go:"GO:0038061"(NIK/NF-kappaB signaling)|go:"GO:0039535"(regulation of RIG-I signaling pathway)|go:"GO:0042981"(regulation of apoptotic process)|refseq:NP_001156.1|refseq:NP_892007.1|refseq:XP_016873132.1|dip:DIP-33720N|go:"GO:0043027"(cysteine-type endopeptidase inhibitor activity involved in apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045088"(regulation of innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0046872"(metal ion binding)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060544"(regulation of necroptotic process)|go:"GO:0060546"(negative regulation of necroptotic process)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070424"(regulation of nucleotide-binding oligomerization domain containing signaling pathway)|go:"GO:2000116"(regulation of cysteine-type endopeptidase activity)|interpro:IPR001315(Caspase Recruitment)|interpro:IPR001370(Proteinase inhibitor I32, inhibitor of apoptosis)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR011029(DEATH-like)|rcsb pdb:2UVL|rcsb pdb:3EB5|rcsb pdb:3EB6|rcsb pdb:3M0A|rcsb pdb:3M0D|reactome:R-HSA-168638|reactome:R-HSA-168927|reactome:R-HSA-5213460|reactome:R-HSA-5357905|reactome:R-HSA-5357956|reactome:R-HSA-5668541|reactome:R-HSA-5675482|reactome:R-HSA-5676594|reactome:R-HSA-5689880|reactome:R-HSA-937041	refseq:NP_003325.2|refseq:NP_695012.1|refseq:XP_016885269.1|refseq:XP_016885270.1|dip:DIP-33686N|ensembl:ENSG00000130985(gene)|ensembl:ENST00000335972(transcript)|ensembl:ENST00000377351(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0004839"(ubiquitin activating enzyme activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0032446"(protein modification by small protein conjugation)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000011(Ubiquitin-activating enzyme, E1)|interpro:IPR000594(UBA/THIF-type NAD/FAD binding fold)|interpro:IPR018074|interpro:IPR018075|interpro:IPR018965|interpro:IPR019572|interpro:IPR032418|interpro:IPR032420|interpro:IPR033127|interpro:IPR035985|interpro:IPR038252|interpro:IPR042063|interpro:IPR042302|interpro:IPR042449|mint:P22314|rcsb pdb:4P22|rcsb pdb:6DC6|reactome:R-HSA-8866652|reactome:R-HSA-983168	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S2|caution:"UBE2N has been marked as the enzyme in this assay, although it is the UBE2N-UBE2V1 complex that has ubiquitinase (E3) activity. Neither UBE2N nor UBE2V1 have E2 or E3 activity on their own."|resulting-ptm:Q13489 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:TBTCMhQ/t2ZIBvxbWIiiv4oo9bc9606	rogid:q+vEeA0XLST0Zz173bmEt0dNbDE9606	intact-crc:17101F1191F49B3C|rigid:kdne4JjpwsV3jb+1E0Z4b/K7tWg	false	-	his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q13489	uniprotkb:P61088	intact:EBI-517709|uniprotkb:Q16628|uniprotkb:Q9HC27|uniprotkb:Q9UP46|ensembl:ENSP00000263464|ensembl:ENSP00000432907|ensembl:ENSP00000481903|ensembl:ENSP00000501119	intact:EBI-1052908|uniprotkb:Q16781|uniprotkb:Q53Y81|ensembl:ENSP00000316176	psi-mi:birc3_human(display_long)|uniprotkb:Inhibitor of apoptosis protein 1(gene name synonym)|uniprotkb:TNFR2-TRAF-signaling complex protein 1(gene name synonym)|uniprotkb:IAP homolog C(gene name synonym)|uniprotkb:Apoptosis inhibitor 2(gene name synonym)|uniprotkb:RING finger protein 49(gene name synonym)|uniprotkb:BIRC3(gene name)|psi-mi:BIRC3(display_short)|uniprotkb:API2(gene name synonym)|uniprotkb:MIHC(gene name synonym)|uniprotkb:RNF49(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase BIRC3(gene name synonym)|uniprotkb:Cellular inhibitor of apoptosis 2(gene name synonym)	psi-mi:ube2n_human(display_long)|uniprotkb:Ubiquitin-protein ligase N(gene name synonym)|uniprotkb:Ubiquitin carrier protein N(gene name synonym)|uniprotkb:Ubc13(gene name synonym)|uniprotkb:Bendless-like ubiquitin-conjugating enzyme(gene name synonym)|uniprotkb:UBE2N(gene name)|psi-mi:UBE2N(display_short)|uniprotkb:BLU(gene name synonym)|uniprotkb:UbcH13(gene name synonym)|uniprotkb:E2 ubiquitin-conjugating enzyme N(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9970557|imex:IM-22822-31	author-confidence:Z-score = 18.64	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000023445(gene)|ensembl:ENST00000263464(transcript)|ensembl:ENST00000526421(transcript)|ensembl:ENST00000532808(transcript)|ensembl:ENST00000615299(transcript)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0007283"(spermatogenesis)|go:"GO:0016740"(transferase activity)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034121"(regulation of toll-like receptor signaling pathway)|go:"GO:0038061"(NIK/NF-kappaB signaling)|go:"GO:0039535"(regulation of RIG-I signaling pathway)|go:"GO:0042981"(regulation of apoptotic process)|refseq:NP_001156.1|refseq:NP_892007.1|refseq:XP_016873132.1|dip:DIP-33720N|go:"GO:0043027"(cysteine-type endopeptidase inhibitor activity involved in apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045088"(regulation of innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0046872"(metal ion binding)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060544"(regulation of necroptotic process)|go:"GO:0060546"(negative regulation of necroptotic process)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070424"(regulation of nucleotide-binding oligomerization domain containing signaling pathway)|go:"GO:2000116"(regulation of cysteine-type endopeptidase activity)|interpro:IPR001315(Caspase Recruitment)|interpro:IPR001370(Proteinase inhibitor I32, inhibitor of apoptosis)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR011029(DEATH-like)|rcsb pdb:2UVL|rcsb pdb:3EB5|rcsb pdb:3EB6|rcsb pdb:3M0A|rcsb pdb:3M0D|reactome:R-HSA-168638|reactome:R-HSA-168927|reactome:R-HSA-5213460|reactome:R-HSA-5357905|reactome:R-HSA-5357956|reactome:R-HSA-5668541|reactome:R-HSA-5675482|reactome:R-HSA-5676594|reactome:R-HSA-5689880|reactome:R-HSA-937041	refseq:NP_003339.1|dip:DIP-29829N|ensembl:ENSG00000177889(gene)|ensembl:ENST00000318066(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000729"(DNA double-strand break processing)|go:"GO:0001650"(fibrillar center)|go:"GO:0003723"(RNA binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006282"(regulation of DNA repair)|go:"GO:0006301"(postreplication repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016574"(histone ubiquitination)|go:"GO:0031058"(positive regulation of histone modification)|go:"GO:0031372"(UBC13-MMS2 complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033182"(regulation of histone ubiquitination)|go:"GO:0035370"(UBC13-UEV1A complex)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0061631"(ubiquitin conjugating enzyme activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070534"(protein K63-linked ubiquitination)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|interpro:IPR023313|rcsb pdb:1J7D|rcsb pdb:2C2V|rcsb pdb:3HCT|rcsb pdb:3HCU|rcsb pdb:3VON|rcsb pdb:3W31|rcsb pdb:4DHI|rcsb pdb:4DHJ|rcsb pdb:4DHZ|rcsb pdb:4IP3|rcsb pdb:4NR3|rcsb pdb:4NRG|rcsb pdb:4NRI|rcsb pdb:4ONL|rcsb pdb:4ONM|rcsb pdb:4ONN|rcsb pdb:4ORH|rcsb pdb:4TKP|rcsb pdb:4WHV|rcsb pdb:5AIT|rcsb pdb:5AIU|rcsb pdb:5EYA|rcsb pdb:5H7S|rcsb pdb:5VNZ|rcsb pdb:5VO0|rcsb pdb:5YWR|rcsb pdb:6D6I|rcsb pdb:6JKY|rcsb pdb:6KFP|rcsb pdb:6KG6|rcsb pdb:6KL4|rcsb pdb:6LP2|rcsb pdb:6P5B|rcsb pdb:6S53|reactome:R-HSA-168927|reactome:R-HSA-202424|reactome:R-HSA-2871837|reactome:R-HSA-445989|reactome:R-HSA-450302|reactome:R-HSA-450321|reactome:R-HSA-5607764|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-5696395|reactome:R-HSA-69473|reactome:R-HSA-8866654|reactome:R-HSA-9020702|reactome:R-HSA-937039|reactome:R-HSA-937041|reactome:R-HSA-9646399|reactome:R-HSA-975110|reactome:R-HSA-975144|reactome:R-HSA-983168|rcsb pdb:6ULH|rcsb pdb:6UMP|rcsb pdb:6UMS|rcsb pdb:7BBD|rcsb pdb:7BBF|rcsb pdb:7BXG|reactome:R-HSA-1169408|reactome:R-HSA-168638	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S2|caution:"UBE2N has been marked as the enzyme in this assay, although it is the UBE2N-UBE2V1 complex that has ubiquitinase (E3) activity. Neither UBE2N nor UBE2V1 have E2 or E3 activity on their own."|resulting-ptm:Q13489 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:TBTCMhQ/t2ZIBvxbWIiiv4oo9bc9606	rogid:dqdszHlq5FLPHC6UWX6uvkC6Yz89606	intact-crc:17101F1191F49B3C|rigid:kdne4JjpwsV3jb+1E0Z4b/K7tWg	false	-	his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q1RMX2	uniprotkb:Q13404	intact:EBI-9916189|ensembl:ENSBTAP00000049292	intact:EBI-1050671|uniprotkb:Q13403|uniprotkb:Q13532|uniprotkb:Q96H34|uniprotkb:Q9GZT0|uniprotkb:Q9GZW1|uniprotkb:Q9H4J3|uniprotkb:Q9H4J4|uniprotkb:Q9UKL1|uniprotkb:Q9UM48|uniprotkb:Q9UM49|uniprotkb:Q9UM50|uniprotkb:Q5TGE3|uniprotkb:E1P629|uniprotkb:Q5TGE0|ensembl:ENSP00000360739	psi-mi:ub2d2_bovin(display_long)|uniprotkb:UBC4(gene name synonym)|uniprotkb:UBCH4(gene name synonym)|uniprotkb:UBCH5B(gene name synonym)|uniprotkb:Ubiquitin carrier protein D2(gene name synonym)|uniprotkb:Ubiquitin-protein ligase D2(gene name synonym)|uniprotkb:UBE2D2(gene name)|psi-mi:UBE2D2(display_short)|uniprotkb:"(E3-independent) E2 ubiquitin-conjugating enzyme D2"(gene name synonym)|uniprotkb:E2 ubiquitin-conjugating enzyme D2(gene name synonym)	psi-mi:ub2v1_human(display_long)|uniprotkb:CROC-1(gene name synonym)|uniprotkb:TRAF6-regulated IKK activator 1 beta Uev1A(gene name synonym)|uniprotkb:P/OKcl.19(orf name)|uniprotkb:UBE2V1(gene name)|psi-mi:UBE2V1(display_short)|uniprotkb:CROC1(gene name synonym)|uniprotkb:UBE2V(gene name synonym)|uniprotkb:UEV1(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:9913(bovin)|taxid:9913("Bos taurus (Bovine)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9970620|imex:IM-22822-34	author-confidence:Z-score = 3.76	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001039961.1|ensembl:ENSBTAG00000004161(gene)|ensembl:ENSBTAT00000055723(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0061631"(ubiquitin conjugating enzyme activity)|go:"GO:0070936"(protein K48-linked ubiquitination)|go:"GO:0070979"(protein K11-linked ubiquitination)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|interpro:IPR023313|reactome:R-BTA-1234176|reactome:R-BTA-8866654|reactome:R-BTA-9705462|reactome:R-BTA-983168	refseq:NP_001027459.1|refseq:NP_068823.2|refseq:NP_071887.1|refseq:NP_954595.1|refseq:NP_954673.1|refseq:NP_001244322.1|refseq:NP_001244323.1|refseq:NP_001244325.1|ensembl:ENSG00000244687(gene)|ensembl:ENST00000371674(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006282"(regulation of DNA repair)|go:"GO:0006301"(postreplication repair)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0030154"(cell differentiation)|go:"GO:0031371"(ubiquitin conjugating enzyme complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035370"(UBC13-UEV1A complex)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070534"(protein K63-linked ubiquitination)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|rcsb pdb:2A4D|rcsb pdb:2C2V|rcsb pdb:2HLW|rcsb pdb:6D6I|reactome:R-HSA-168638|reactome:R-HSA-168927|reactome:R-HSA-202424|reactome:R-HSA-2871837|reactome:R-HSA-445989|reactome:R-HSA-450302|reactome:R-HSA-450321|reactome:R-HSA-5607764|reactome:R-HSA-9020702|reactome:R-HSA-937039|reactome:R-HSA-937041|reactome:R-HSA-9646399|reactome:R-HSA-975110|reactome:R-HSA-975144|reactome:R-HSA-983168|dip:DIP-41911N	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S2|caution:"UBE2N has been marked as the enzyme in this assay, although it is the UBE2N-UBE2V1 complex that has ubiquitinase (E3) activity. Neither UBE2N nor UBE2V1 have E2 or E3 activity on their own."|resulting-ptm:Q1RMX2 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:vVGrEi0osU/WG0Y9qRCFMT4lgvg9913	rogid:x95N7Dj2KIqu5gySX59xLmfthUg9606	intact-crc:E67E99A8568EC9FE|rigid:aPAOV5o2hQZ1wwPaUthrVRDAugI	false	-	his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q1RMX2	uniprotkb:P22314	intact:EBI-9916189|ensembl:ENSBTAP00000049292	intact:EBI-709688|uniprotkb:Q96E13|uniprotkb:Q5JRR8|ensembl:ENSP00000338413|ensembl:ENSP00000366568	psi-mi:ub2d2_bovin(display_long)|uniprotkb:UBC4(gene name synonym)|uniprotkb:UBCH4(gene name synonym)|uniprotkb:UBCH5B(gene name synonym)|uniprotkb:Ubiquitin carrier protein D2(gene name synonym)|uniprotkb:Ubiquitin-protein ligase D2(gene name synonym)|uniprotkb:UBE2D2(gene name)|psi-mi:UBE2D2(display_short)|uniprotkb:"(E3-independent) E2 ubiquitin-conjugating enzyme D2"(gene name synonym)|uniprotkb:E2 ubiquitin-conjugating enzyme D2(gene name synonym)	psi-mi:uba1_human(display_long)|uniprotkb:Ubiquitin-activating enzyme E1(gene name synonym)|uniprotkb:Protein A1S9(gene name synonym)|uniprotkb:UBA1(gene name)|psi-mi:UBA1(display_short)|uniprotkb:A1S9T(gene name synonym)|uniprotkb:UBE1(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:9913(bovin)|taxid:9913("Bos taurus (Bovine)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9970620|imex:IM-22822-34	author-confidence:Z-score = 3.76	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001039961.1|ensembl:ENSBTAG00000004161(gene)|ensembl:ENSBTAT00000055723(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0061631"(ubiquitin conjugating enzyme activity)|go:"GO:0070936"(protein K48-linked ubiquitination)|go:"GO:0070979"(protein K11-linked ubiquitination)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|interpro:IPR023313|reactome:R-BTA-1234176|reactome:R-BTA-8866654|reactome:R-BTA-9705462|reactome:R-BTA-983168	refseq:NP_003325.2|refseq:NP_695012.1|refseq:XP_016885269.1|refseq:XP_016885270.1|dip:DIP-33686N|ensembl:ENSG00000130985(gene)|ensembl:ENST00000335972(transcript)|ensembl:ENST00000377351(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0004839"(ubiquitin activating enzyme activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0032446"(protein modification by small protein conjugation)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000011(Ubiquitin-activating enzyme, E1)|interpro:IPR000594(UBA/THIF-type NAD/FAD binding fold)|interpro:IPR018074|interpro:IPR018075|interpro:IPR018965|interpro:IPR019572|interpro:IPR032418|interpro:IPR032420|interpro:IPR033127|interpro:IPR035985|interpro:IPR038252|interpro:IPR042063|interpro:IPR042302|interpro:IPR042449|mint:P22314|rcsb pdb:4P22|rcsb pdb:6DC6|reactome:R-HSA-8866652|reactome:R-HSA-983168	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S2|caution:"UBE2N has been marked as the enzyme in this assay, although it is the UBE2N-UBE2V1 complex that has ubiquitinase (E3) activity. Neither UBE2N nor UBE2V1 have E2 or E3 activity on their own."|resulting-ptm:Q1RMX2 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:vVGrEi0osU/WG0Y9qRCFMT4lgvg9913	rogid:q+vEeA0XLST0Zz173bmEt0dNbDE9606	intact-crc:E67E99A8568EC9FE|rigid:aPAOV5o2hQZ1wwPaUthrVRDAugI	false	-	his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q1RMX2	uniprotkb:P61088	intact:EBI-9916189|ensembl:ENSBTAP00000049292	intact:EBI-1052908|uniprotkb:Q16781|uniprotkb:Q53Y81|ensembl:ENSP00000316176	psi-mi:ub2d2_bovin(display_long)|uniprotkb:UBC4(gene name synonym)|uniprotkb:UBCH4(gene name synonym)|uniprotkb:UBCH5B(gene name synonym)|uniprotkb:Ubiquitin carrier protein D2(gene name synonym)|uniprotkb:Ubiquitin-protein ligase D2(gene name synonym)|uniprotkb:UBE2D2(gene name)|psi-mi:UBE2D2(display_short)|uniprotkb:"(E3-independent) E2 ubiquitin-conjugating enzyme D2"(gene name synonym)|uniprotkb:E2 ubiquitin-conjugating enzyme D2(gene name synonym)	psi-mi:ube2n_human(display_long)|uniprotkb:Ubiquitin-protein ligase N(gene name synonym)|uniprotkb:Ubiquitin carrier protein N(gene name synonym)|uniprotkb:Ubc13(gene name synonym)|uniprotkb:Bendless-like ubiquitin-conjugating enzyme(gene name synonym)|uniprotkb:UBE2N(gene name)|psi-mi:UBE2N(display_short)|uniprotkb:BLU(gene name synonym)|uniprotkb:UbcH13(gene name synonym)|uniprotkb:E2 ubiquitin-conjugating enzyme N(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:9913(bovin)|taxid:9913("Bos taurus (Bovine)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9970620|imex:IM-22822-34	author-confidence:Z-score = 3.76	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001039961.1|ensembl:ENSBTAG00000004161(gene)|ensembl:ENSBTAT00000055723(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0061631"(ubiquitin conjugating enzyme activity)|go:"GO:0070936"(protein K48-linked ubiquitination)|go:"GO:0070979"(protein K11-linked ubiquitination)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|interpro:IPR023313|reactome:R-BTA-1234176|reactome:R-BTA-8866654|reactome:R-BTA-9705462|reactome:R-BTA-983168	refseq:NP_003339.1|dip:DIP-29829N|ensembl:ENSG00000177889(gene)|ensembl:ENST00000318066(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000729"(DNA double-strand break processing)|go:"GO:0001650"(fibrillar center)|go:"GO:0003723"(RNA binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006282"(regulation of DNA repair)|go:"GO:0006301"(postreplication repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016574"(histone ubiquitination)|go:"GO:0031058"(positive regulation of histone modification)|go:"GO:0031372"(UBC13-MMS2 complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033182"(regulation of histone ubiquitination)|go:"GO:0035370"(UBC13-UEV1A complex)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0061631"(ubiquitin conjugating enzyme activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070534"(protein K63-linked ubiquitination)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|interpro:IPR023313|rcsb pdb:1J7D|rcsb pdb:2C2V|rcsb pdb:3HCT|rcsb pdb:3HCU|rcsb pdb:3VON|rcsb pdb:3W31|rcsb pdb:4DHI|rcsb pdb:4DHJ|rcsb pdb:4DHZ|rcsb pdb:4IP3|rcsb pdb:4NR3|rcsb pdb:4NRG|rcsb pdb:4NRI|rcsb pdb:4ONL|rcsb pdb:4ONM|rcsb pdb:4ONN|rcsb pdb:4ORH|rcsb pdb:4TKP|rcsb pdb:4WHV|rcsb pdb:5AIT|rcsb pdb:5AIU|rcsb pdb:5EYA|rcsb pdb:5H7S|rcsb pdb:5VNZ|rcsb pdb:5VO0|rcsb pdb:5YWR|rcsb pdb:6D6I|rcsb pdb:6JKY|rcsb pdb:6KFP|rcsb pdb:6KG6|rcsb pdb:6KL4|rcsb pdb:6LP2|rcsb pdb:6P5B|rcsb pdb:6S53|reactome:R-HSA-168927|reactome:R-HSA-202424|reactome:R-HSA-2871837|reactome:R-HSA-445989|reactome:R-HSA-450302|reactome:R-HSA-450321|reactome:R-HSA-5607764|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-5696395|reactome:R-HSA-69473|reactome:R-HSA-8866654|reactome:R-HSA-9020702|reactome:R-HSA-937039|reactome:R-HSA-937041|reactome:R-HSA-9646399|reactome:R-HSA-975110|reactome:R-HSA-975144|reactome:R-HSA-983168|rcsb pdb:6ULH|rcsb pdb:6UMP|rcsb pdb:6UMS|rcsb pdb:7BBD|rcsb pdb:7BBF|rcsb pdb:7BXG|reactome:R-HSA-1169408|reactome:R-HSA-168638	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S2|caution:"UBE2N has been marked as the enzyme in this assay, although it is the UBE2N-UBE2V1 complex that has ubiquitinase (E3) activity. Neither UBE2N nor UBE2V1 have E2 or E3 activity on their own."|resulting-ptm:Q1RMX2 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:vVGrEi0osU/WG0Y9qRCFMT4lgvg9913	rogid:dqdszHlq5FLPHC6UWX6uvkC6Yz89606	intact-crc:E67E99A8568EC9FE|rigid:aPAOV5o2hQZ1wwPaUthrVRDAugI	false	-	his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q68E01	uniprotkb:Q13404	intact:EBI-2680854|uniprotkb:Q8TB23|uniprotkb:Q6MZQ4|uniprotkb:Q9H6S9|uniprotkb:Q6AI57|uniprotkb:Q5VUQ6|uniprotkb:Q4G0E5|uniprotkb:B4DQC8|uniprotkb:B4E3U9|uniprotkb:A8K1W0|uniprotkb:Q8NC46|uniprotkb:Q68DJ1|uniprotkb:Q6DKG7|uniprotkb:Q5VUR1|uniprotkb:Q6MZZ9|uniprotkb:Q5VUQ5|uniprotkb:Q69YR5|uniprotkb:Q5VUR0|uniprotkb:D3DV57	intact:EBI-1050671|uniprotkb:Q13403|uniprotkb:Q13532|uniprotkb:Q96H34|uniprotkb:Q9GZT0|uniprotkb:Q9GZW1|uniprotkb:Q9H4J3|uniprotkb:Q9H4J4|uniprotkb:Q9UKL1|uniprotkb:Q9UM48|uniprotkb:Q9UM49|uniprotkb:Q9UM50|uniprotkb:Q5TGE3|uniprotkb:E1P629|uniprotkb:Q5TGE0|ensembl:ENSP00000360739	psi-mi:int3_human(display_long)|uniprotkb:INTS3(gene name)|psi-mi:INTS3(display_short)|uniprotkb:C1orf193(gene name synonym)|uniprotkb:C1orf60(gene name synonym)|uniprotkb:SOSS complex subunit A(gene name synonym)|uniprotkb:Sensor of single-strand DNA complex subunit A(gene name synonym)	psi-mi:ub2v1_human(display_long)|uniprotkb:CROC-1(gene name synonym)|uniprotkb:TRAF6-regulated IKK activator 1 beta Uev1A(gene name synonym)|uniprotkb:P/OKcl.19(orf name)|uniprotkb:UBE2V1(gene name)|psi-mi:UBE2V1(display_short)|uniprotkb:CROC1(gene name synonym)|uniprotkb:UBE2V(gene name synonym)|uniprotkb:UEV1(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9970641|imex:IM-22822-35	author-confidence:Z-score = 4.19	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_075391.3|interpro:IPR019333|refseq:XP_005245518.1|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0016180"(snRNA processing)|go:"GO:0032039"(integrator complex)|go:"GO:0035861"(site of double-strand break)|go:"GO:0044818"(mitotic G2/M transition checkpoint)|go:"GO:0070876"(SOSS complex)|rcsb pdb:4OWT|rcsb pdb:4OWW|rcsb pdb:4OWX|rcsb pdb:6WLG|reactome:R-HSA-6807505|refseq:NP_001311404.1|mint:Q68E01	refseq:NP_001027459.1|refseq:NP_068823.2|refseq:NP_071887.1|refseq:NP_954595.1|refseq:NP_954673.1|refseq:NP_001244322.1|refseq:NP_001244323.1|refseq:NP_001244325.1|ensembl:ENSG00000244687(gene)|ensembl:ENST00000371674(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006282"(regulation of DNA repair)|go:"GO:0006301"(postreplication repair)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0030154"(cell differentiation)|go:"GO:0031371"(ubiquitin conjugating enzyme complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035370"(UBC13-UEV1A complex)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070534"(protein K63-linked ubiquitination)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|rcsb pdb:2A4D|rcsb pdb:2C2V|rcsb pdb:2HLW|rcsb pdb:6D6I|reactome:R-HSA-168638|reactome:R-HSA-168927|reactome:R-HSA-202424|reactome:R-HSA-2871837|reactome:R-HSA-445989|reactome:R-HSA-450302|reactome:R-HSA-450321|reactome:R-HSA-5607764|reactome:R-HSA-9020702|reactome:R-HSA-937039|reactome:R-HSA-937041|reactome:R-HSA-9646399|reactome:R-HSA-975110|reactome:R-HSA-975144|reactome:R-HSA-983168|dip:DIP-41911N	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S2|caution:"UBE2N has been marked as the enzyme in this assay, although it is the UBE2N-UBE2V1 complex that has ubiquitinase (E3) activity. Neither UBE2N nor UBE2V1 have E2 or E3 activity on their own."|resulting-ptm:Q68E01 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:GxQTTVSOwBdWifr7ZdM8Zbqxy5M9606	rogid:x95N7Dj2KIqu5gySX59xLmfthUg9606	intact-crc:549AF16A84ECF9AE|rigid:uYR+tlM8VgZWVY74p6d1qh6nTy0	false	-	his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q68E01	uniprotkb:P22314	intact:EBI-2680854|uniprotkb:Q8TB23|uniprotkb:Q6MZQ4|uniprotkb:Q9H6S9|uniprotkb:Q6AI57|uniprotkb:Q5VUQ6|uniprotkb:Q4G0E5|uniprotkb:B4DQC8|uniprotkb:B4E3U9|uniprotkb:A8K1W0|uniprotkb:Q8NC46|uniprotkb:Q68DJ1|uniprotkb:Q6DKG7|uniprotkb:Q5VUR1|uniprotkb:Q6MZZ9|uniprotkb:Q5VUQ5|uniprotkb:Q69YR5|uniprotkb:Q5VUR0|uniprotkb:D3DV57	intact:EBI-709688|uniprotkb:Q96E13|uniprotkb:Q5JRR8|ensembl:ENSP00000338413|ensembl:ENSP00000366568	psi-mi:int3_human(display_long)|uniprotkb:INTS3(gene name)|psi-mi:INTS3(display_short)|uniprotkb:C1orf193(gene name synonym)|uniprotkb:C1orf60(gene name synonym)|uniprotkb:SOSS complex subunit A(gene name synonym)|uniprotkb:Sensor of single-strand DNA complex subunit A(gene name synonym)	psi-mi:uba1_human(display_long)|uniprotkb:Ubiquitin-activating enzyme E1(gene name synonym)|uniprotkb:Protein A1S9(gene name synonym)|uniprotkb:UBA1(gene name)|psi-mi:UBA1(display_short)|uniprotkb:A1S9T(gene name synonym)|uniprotkb:UBE1(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9970641|imex:IM-22822-35	author-confidence:Z-score = 4.19	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_075391.3|interpro:IPR019333|refseq:XP_005245518.1|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0016180"(snRNA processing)|go:"GO:0032039"(integrator complex)|go:"GO:0035861"(site of double-strand break)|go:"GO:0044818"(mitotic G2/M transition checkpoint)|go:"GO:0070876"(SOSS complex)|rcsb pdb:4OWT|rcsb pdb:4OWW|rcsb pdb:4OWX|rcsb pdb:6WLG|reactome:R-HSA-6807505|refseq:NP_001311404.1|mint:Q68E01	refseq:NP_003325.2|refseq:NP_695012.1|refseq:XP_016885269.1|refseq:XP_016885270.1|dip:DIP-33686N|ensembl:ENSG00000130985(gene)|ensembl:ENST00000335972(transcript)|ensembl:ENST00000377351(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0004839"(ubiquitin activating enzyme activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0032446"(protein modification by small protein conjugation)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000011(Ubiquitin-activating enzyme, E1)|interpro:IPR000594(UBA/THIF-type NAD/FAD binding fold)|interpro:IPR018074|interpro:IPR018075|interpro:IPR018965|interpro:IPR019572|interpro:IPR032418|interpro:IPR032420|interpro:IPR033127|interpro:IPR035985|interpro:IPR038252|interpro:IPR042063|interpro:IPR042302|interpro:IPR042449|mint:P22314|rcsb pdb:4P22|rcsb pdb:6DC6|reactome:R-HSA-8866652|reactome:R-HSA-983168	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S2|caution:"UBE2N has been marked as the enzyme in this assay, although it is the UBE2N-UBE2V1 complex that has ubiquitinase (E3) activity. Neither UBE2N nor UBE2V1 have E2 or E3 activity on their own."|resulting-ptm:Q68E01 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:GxQTTVSOwBdWifr7ZdM8Zbqxy5M9606	rogid:q+vEeA0XLST0Zz173bmEt0dNbDE9606	intact-crc:549AF16A84ECF9AE|rigid:uYR+tlM8VgZWVY74p6d1qh6nTy0	false	-	his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q68E01	uniprotkb:P61088	intact:EBI-2680854|uniprotkb:Q8TB23|uniprotkb:Q6MZQ4|uniprotkb:Q9H6S9|uniprotkb:Q6AI57|uniprotkb:Q5VUQ6|uniprotkb:Q4G0E5|uniprotkb:B4DQC8|uniprotkb:B4E3U9|uniprotkb:A8K1W0|uniprotkb:Q8NC46|uniprotkb:Q68DJ1|uniprotkb:Q6DKG7|uniprotkb:Q5VUR1|uniprotkb:Q6MZZ9|uniprotkb:Q5VUQ5|uniprotkb:Q69YR5|uniprotkb:Q5VUR0|uniprotkb:D3DV57	intact:EBI-1052908|uniprotkb:Q16781|uniprotkb:Q53Y81|ensembl:ENSP00000316176	psi-mi:int3_human(display_long)|uniprotkb:INTS3(gene name)|psi-mi:INTS3(display_short)|uniprotkb:C1orf193(gene name synonym)|uniprotkb:C1orf60(gene name synonym)|uniprotkb:SOSS complex subunit A(gene name synonym)|uniprotkb:Sensor of single-strand DNA complex subunit A(gene name synonym)	psi-mi:ube2n_human(display_long)|uniprotkb:Ubiquitin-protein ligase N(gene name synonym)|uniprotkb:Ubiquitin carrier protein N(gene name synonym)|uniprotkb:Ubc13(gene name synonym)|uniprotkb:Bendless-like ubiquitin-conjugating enzyme(gene name synonym)|uniprotkb:UBE2N(gene name)|psi-mi:UBE2N(display_short)|uniprotkb:BLU(gene name synonym)|uniprotkb:UbcH13(gene name synonym)|uniprotkb:E2 ubiquitin-conjugating enzyme N(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9970641|imex:IM-22822-35	author-confidence:Z-score = 4.19	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_075391.3|interpro:IPR019333|refseq:XP_005245518.1|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0016180"(snRNA processing)|go:"GO:0032039"(integrator complex)|go:"GO:0035861"(site of double-strand break)|go:"GO:0044818"(mitotic G2/M transition checkpoint)|go:"GO:0070876"(SOSS complex)|rcsb pdb:4OWT|rcsb pdb:4OWW|rcsb pdb:4OWX|rcsb pdb:6WLG|reactome:R-HSA-6807505|refseq:NP_001311404.1|mint:Q68E01	refseq:NP_003339.1|dip:DIP-29829N|ensembl:ENSG00000177889(gene)|ensembl:ENST00000318066(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000729"(DNA double-strand break processing)|go:"GO:0001650"(fibrillar center)|go:"GO:0003723"(RNA binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006282"(regulation of DNA repair)|go:"GO:0006301"(postreplication repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016574"(histone ubiquitination)|go:"GO:0031058"(positive regulation of histone modification)|go:"GO:0031372"(UBC13-MMS2 complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033182"(regulation of histone ubiquitination)|go:"GO:0035370"(UBC13-UEV1A complex)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0061631"(ubiquitin conjugating enzyme activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070534"(protein K63-linked ubiquitination)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|interpro:IPR023313|rcsb pdb:1J7D|rcsb pdb:2C2V|rcsb pdb:3HCT|rcsb pdb:3HCU|rcsb pdb:3VON|rcsb pdb:3W31|rcsb pdb:4DHI|rcsb pdb:4DHJ|rcsb pdb:4DHZ|rcsb pdb:4IP3|rcsb pdb:4NR3|rcsb pdb:4NRG|rcsb pdb:4NRI|rcsb pdb:4ONL|rcsb pdb:4ONM|rcsb pdb:4ONN|rcsb pdb:4ORH|rcsb pdb:4TKP|rcsb pdb:4WHV|rcsb pdb:5AIT|rcsb pdb:5AIU|rcsb pdb:5EYA|rcsb pdb:5H7S|rcsb pdb:5VNZ|rcsb pdb:5VO0|rcsb pdb:5YWR|rcsb pdb:6D6I|rcsb pdb:6JKY|rcsb pdb:6KFP|rcsb pdb:6KG6|rcsb pdb:6KL4|rcsb pdb:6LP2|rcsb pdb:6P5B|rcsb pdb:6S53|reactome:R-HSA-168927|reactome:R-HSA-202424|reactome:R-HSA-2871837|reactome:R-HSA-445989|reactome:R-HSA-450302|reactome:R-HSA-450321|reactome:R-HSA-5607764|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-5696395|reactome:R-HSA-69473|reactome:R-HSA-8866654|reactome:R-HSA-9020702|reactome:R-HSA-937039|reactome:R-HSA-937041|reactome:R-HSA-9646399|reactome:R-HSA-975110|reactome:R-HSA-975144|reactome:R-HSA-983168|rcsb pdb:6ULH|rcsb pdb:6UMP|rcsb pdb:6UMS|rcsb pdb:7BBD|rcsb pdb:7BBF|rcsb pdb:7BXG|reactome:R-HSA-1169408|reactome:R-HSA-168638	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S2|caution:"UBE2N has been marked as the enzyme in this assay, although it is the UBE2N-UBE2V1 complex that has ubiquitinase (E3) activity. Neither UBE2N nor UBE2V1 have E2 or E3 activity on their own."|resulting-ptm:Q68E01 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:GxQTTVSOwBdWifr7ZdM8Zbqxy5M9606	rogid:dqdszHlq5FLPHC6UWX6uvkC6Yz89606	intact-crc:549AF16A84ECF9AE|rigid:uYR+tlM8VgZWVY74p6d1qh6nTy0	false	-	his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q6PCD5	uniprotkb:Q13404	intact:EBI-2129159|uniprotkb:Q9H9Q3|uniprotkb:Q9NVT4|uniprotkb:Q5XKR3|uniprotkb:A8K585|uniprotkb:B2RE35|uniprotkb:D3DUJ8|ensembl:ENSP00000354361|ensembl:ENSP00000460049	intact:EBI-1050671|uniprotkb:Q13403|uniprotkb:Q13532|uniprotkb:Q96H34|uniprotkb:Q9GZT0|uniprotkb:Q9GZW1|uniprotkb:Q9H4J3|uniprotkb:Q9H4J4|uniprotkb:Q9UKL1|uniprotkb:Q9UM48|uniprotkb:Q9UM49|uniprotkb:Q9UM50|uniprotkb:Q5TGE3|uniprotkb:E1P629|uniprotkb:Q5TGE0|ensembl:ENSP00000360739	psi-mi:rfwd3_human(display_long)|uniprotkb:RFWD3(gene name)|psi-mi:RFWD3(display_short)|uniprotkb:RING finger and WD repeat domain-containing protein 3(gene name synonym)|uniprotkb:RNF201(gene name synonym)|uniprotkb:RING finger protein 201(gene name synonym)	psi-mi:ub2v1_human(display_long)|uniprotkb:CROC-1(gene name synonym)|uniprotkb:TRAF6-regulated IKK activator 1 beta Uev1A(gene name synonym)|uniprotkb:P/OKcl.19(orf name)|uniprotkb:UBE2V1(gene name)|psi-mi:UBE2V1(display_short)|uniprotkb:CROC1(gene name synonym)|uniprotkb:UBE2V(gene name synonym)|uniprotkb:UEV1(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9970662|imex:IM-22822-36	author-confidence:Z-score = 13.34	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011521493.1|refseq:NP_060594.3|refseq:XP_016878880.1|refseq:XP_005256078.1|refseq:XP_005256079.1|dip:DIP-52688N|ensembl:ENSG00000168411(gene)|ensembl:ENST00000361070(transcript)|ensembl:ENST00000571750(transcript)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0002039"(p53 binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016605"(PML body)|go:"GO:0031052"(chromosome breakage)|go:"GO:0031297"(replication fork processing)|go:"GO:0031571"(mitotic G1 DNA damage checkpoint signaling)|go:"GO:0036297"(interstrand cross-link repair)|go:"GO:0046872"(metal ion binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0090734"(site of DNA damage)|go:"GO:0097371"(MDM2/MDM4 family protein binding)|go:"GO:2000001"(regulation of DNA damage checkpoint)|interpro:IPR001680(WD40 repeat)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR036322|interpro:IPR037381|rcsb pdb:6CVZ	refseq:NP_001027459.1|refseq:NP_068823.2|refseq:NP_071887.1|refseq:NP_954595.1|refseq:NP_954673.1|refseq:NP_001244322.1|refseq:NP_001244323.1|refseq:NP_001244325.1|ensembl:ENSG00000244687(gene)|ensembl:ENST00000371674(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006282"(regulation of DNA repair)|go:"GO:0006301"(postreplication repair)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0030154"(cell differentiation)|go:"GO:0031371"(ubiquitin conjugating enzyme complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035370"(UBC13-UEV1A complex)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070534"(protein K63-linked ubiquitination)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|rcsb pdb:2A4D|rcsb pdb:2C2V|rcsb pdb:2HLW|rcsb pdb:6D6I|reactome:R-HSA-168638|reactome:R-HSA-168927|reactome:R-HSA-202424|reactome:R-HSA-2871837|reactome:R-HSA-445989|reactome:R-HSA-450302|reactome:R-HSA-450321|reactome:R-HSA-5607764|reactome:R-HSA-9020702|reactome:R-HSA-937039|reactome:R-HSA-937041|reactome:R-HSA-9646399|reactome:R-HSA-975110|reactome:R-HSA-975144|reactome:R-HSA-983168|dip:DIP-41911N	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S2|caution:"UBE2N has been marked as the enzyme in this assay, although it is the UBE2N-UBE2V1 complex that has ubiquitinase (E3) activity. Neither UBE2N nor UBE2V1 have E2 or E3 activity on their own."|resulting-ptm:Q6PCD5 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:r7gkMbkS0GKPVn9riLPR34KFaKk9606	rogid:x95N7Dj2KIqu5gySX59xLmfthUg9606	intact-crc:D85F1A14ACFB6515|rigid:0E2DV5WohB2BwH6HhfybX3BTNq8	false	-	his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q6PCD5	uniprotkb:P22314	intact:EBI-2129159|uniprotkb:Q9H9Q3|uniprotkb:Q9NVT4|uniprotkb:Q5XKR3|uniprotkb:A8K585|uniprotkb:B2RE35|uniprotkb:D3DUJ8|ensembl:ENSP00000354361|ensembl:ENSP00000460049	intact:EBI-709688|uniprotkb:Q96E13|uniprotkb:Q5JRR8|ensembl:ENSP00000338413|ensembl:ENSP00000366568	psi-mi:rfwd3_human(display_long)|uniprotkb:RFWD3(gene name)|psi-mi:RFWD3(display_short)|uniprotkb:RING finger and WD repeat domain-containing protein 3(gene name synonym)|uniprotkb:RNF201(gene name synonym)|uniprotkb:RING finger protein 201(gene name synonym)	psi-mi:uba1_human(display_long)|uniprotkb:Ubiquitin-activating enzyme E1(gene name synonym)|uniprotkb:Protein A1S9(gene name synonym)|uniprotkb:UBA1(gene name)|psi-mi:UBA1(display_short)|uniprotkb:A1S9T(gene name synonym)|uniprotkb:UBE1(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9970662|imex:IM-22822-36	author-confidence:Z-score = 13.34	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011521493.1|refseq:NP_060594.3|refseq:XP_016878880.1|refseq:XP_005256078.1|refseq:XP_005256079.1|dip:DIP-52688N|ensembl:ENSG00000168411(gene)|ensembl:ENST00000361070(transcript)|ensembl:ENST00000571750(transcript)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0002039"(p53 binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016605"(PML body)|go:"GO:0031052"(chromosome breakage)|go:"GO:0031297"(replication fork processing)|go:"GO:0031571"(mitotic G1 DNA damage checkpoint signaling)|go:"GO:0036297"(interstrand cross-link repair)|go:"GO:0046872"(metal ion binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0090734"(site of DNA damage)|go:"GO:0097371"(MDM2/MDM4 family protein binding)|go:"GO:2000001"(regulation of DNA damage checkpoint)|interpro:IPR001680(WD40 repeat)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR036322|interpro:IPR037381|rcsb pdb:6CVZ	refseq:NP_003325.2|refseq:NP_695012.1|refseq:XP_016885269.1|refseq:XP_016885270.1|dip:DIP-33686N|ensembl:ENSG00000130985(gene)|ensembl:ENST00000335972(transcript)|ensembl:ENST00000377351(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0004839"(ubiquitin activating enzyme activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0032446"(protein modification by small protein conjugation)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000011(Ubiquitin-activating enzyme, E1)|interpro:IPR000594(UBA/THIF-type NAD/FAD binding fold)|interpro:IPR018074|interpro:IPR018075|interpro:IPR018965|interpro:IPR019572|interpro:IPR032418|interpro:IPR032420|interpro:IPR033127|interpro:IPR035985|interpro:IPR038252|interpro:IPR042063|interpro:IPR042302|interpro:IPR042449|mint:P22314|rcsb pdb:4P22|rcsb pdb:6DC6|reactome:R-HSA-8866652|reactome:R-HSA-983168	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S2|caution:"UBE2N has been marked as the enzyme in this assay, although it is the UBE2N-UBE2V1 complex that has ubiquitinase (E3) activity. Neither UBE2N nor UBE2V1 have E2 or E3 activity on their own."|resulting-ptm:Q6PCD5 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:r7gkMbkS0GKPVn9riLPR34KFaKk9606	rogid:q+vEeA0XLST0Zz173bmEt0dNbDE9606	intact-crc:D85F1A14ACFB6515|rigid:0E2DV5WohB2BwH6HhfybX3BTNq8	false	-	his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q6PCD5	uniprotkb:P61088	intact:EBI-2129159|uniprotkb:Q9H9Q3|uniprotkb:Q9NVT4|uniprotkb:Q5XKR3|uniprotkb:A8K585|uniprotkb:B2RE35|uniprotkb:D3DUJ8|ensembl:ENSP00000354361|ensembl:ENSP00000460049	intact:EBI-1052908|uniprotkb:Q16781|uniprotkb:Q53Y81|ensembl:ENSP00000316176	psi-mi:rfwd3_human(display_long)|uniprotkb:RFWD3(gene name)|psi-mi:RFWD3(display_short)|uniprotkb:RING finger and WD repeat domain-containing protein 3(gene name synonym)|uniprotkb:RNF201(gene name synonym)|uniprotkb:RING finger protein 201(gene name synonym)	psi-mi:ube2n_human(display_long)|uniprotkb:Ubiquitin-protein ligase N(gene name synonym)|uniprotkb:Ubiquitin carrier protein N(gene name synonym)|uniprotkb:Ubc13(gene name synonym)|uniprotkb:Bendless-like ubiquitin-conjugating enzyme(gene name synonym)|uniprotkb:UBE2N(gene name)|psi-mi:UBE2N(display_short)|uniprotkb:BLU(gene name synonym)|uniprotkb:UbcH13(gene name synonym)|uniprotkb:E2 ubiquitin-conjugating enzyme N(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9970662|imex:IM-22822-36	author-confidence:Z-score = 13.34	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011521493.1|refseq:NP_060594.3|refseq:XP_016878880.1|refseq:XP_005256078.1|refseq:XP_005256079.1|dip:DIP-52688N|ensembl:ENSG00000168411(gene)|ensembl:ENST00000361070(transcript)|ensembl:ENST00000571750(transcript)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0002039"(p53 binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016605"(PML body)|go:"GO:0031052"(chromosome breakage)|go:"GO:0031297"(replication fork processing)|go:"GO:0031571"(mitotic G1 DNA damage checkpoint signaling)|go:"GO:0036297"(interstrand cross-link repair)|go:"GO:0046872"(metal ion binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0090734"(site of DNA damage)|go:"GO:0097371"(MDM2/MDM4 family protein binding)|go:"GO:2000001"(regulation of DNA damage checkpoint)|interpro:IPR001680(WD40 repeat)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR036322|interpro:IPR037381|rcsb pdb:6CVZ	refseq:NP_003339.1|dip:DIP-29829N|ensembl:ENSG00000177889(gene)|ensembl:ENST00000318066(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000729"(DNA double-strand break processing)|go:"GO:0001650"(fibrillar center)|go:"GO:0003723"(RNA binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006282"(regulation of DNA repair)|go:"GO:0006301"(postreplication repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016574"(histone ubiquitination)|go:"GO:0031058"(positive regulation of histone modification)|go:"GO:0031372"(UBC13-MMS2 complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033182"(regulation of histone ubiquitination)|go:"GO:0035370"(UBC13-UEV1A complex)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0061631"(ubiquitin conjugating enzyme activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070534"(protein K63-linked ubiquitination)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|interpro:IPR023313|rcsb pdb:1J7D|rcsb pdb:2C2V|rcsb pdb:3HCT|rcsb pdb:3HCU|rcsb pdb:3VON|rcsb pdb:3W31|rcsb pdb:4DHI|rcsb pdb:4DHJ|rcsb pdb:4DHZ|rcsb pdb:4IP3|rcsb pdb:4NR3|rcsb pdb:4NRG|rcsb pdb:4NRI|rcsb pdb:4ONL|rcsb pdb:4ONM|rcsb pdb:4ONN|rcsb pdb:4ORH|rcsb pdb:4TKP|rcsb pdb:4WHV|rcsb pdb:5AIT|rcsb pdb:5AIU|rcsb pdb:5EYA|rcsb pdb:5H7S|rcsb pdb:5VNZ|rcsb pdb:5VO0|rcsb pdb:5YWR|rcsb pdb:6D6I|rcsb pdb:6JKY|rcsb pdb:6KFP|rcsb pdb:6KG6|rcsb pdb:6KL4|rcsb pdb:6LP2|rcsb pdb:6P5B|rcsb pdb:6S53|reactome:R-HSA-168927|reactome:R-HSA-202424|reactome:R-HSA-2871837|reactome:R-HSA-445989|reactome:R-HSA-450302|reactome:R-HSA-450321|reactome:R-HSA-5607764|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-5696395|reactome:R-HSA-69473|reactome:R-HSA-8866654|reactome:R-HSA-9020702|reactome:R-HSA-937039|reactome:R-HSA-937041|reactome:R-HSA-9646399|reactome:R-HSA-975110|reactome:R-HSA-975144|reactome:R-HSA-983168|rcsb pdb:6ULH|rcsb pdb:6UMP|rcsb pdb:6UMS|rcsb pdb:7BBD|rcsb pdb:7BBF|rcsb pdb:7BXG|reactome:R-HSA-1169408|reactome:R-HSA-168638	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S2|caution:"UBE2N has been marked as the enzyme in this assay, although it is the UBE2N-UBE2V1 complex that has ubiquitinase (E3) activity. Neither UBE2N nor UBE2V1 have E2 or E3 activity on their own."|resulting-ptm:Q6PCD5 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:r7gkMbkS0GKPVn9riLPR34KFaKk9606	rogid:dqdszHlq5FLPHC6UWX6uvkC6Yz89606	intact-crc:D85F1A14ACFB6515|rigid:0E2DV5WohB2BwH6HhfybX3BTNq8	false	-	his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q6ZSS7	uniprotkb:Q13404	intact:EBI-2858252|uniprotkb:Q9NXM3|uniprotkb:D3KSZ4|uniprotkb:Q86TH2|ensembl:ENSP00000281416|ensembl:ENSP00000376141	intact:EBI-1050671|uniprotkb:Q13403|uniprotkb:Q13532|uniprotkb:Q96H34|uniprotkb:Q9GZT0|uniprotkb:Q9GZW1|uniprotkb:Q9H4J3|uniprotkb:Q9H4J4|uniprotkb:Q9UKL1|uniprotkb:Q9UM48|uniprotkb:Q9UM49|uniprotkb:Q9UM50|uniprotkb:Q5TGE3|uniprotkb:E1P629|uniprotkb:Q5TGE0|ensembl:ENSP00000360739	psi-mi:mfsd6_human(display_long)|uniprotkb:MFSD6(gene name)|psi-mi:MFSD6(display_short)|uniprotkb:MMR2(gene name synonym)|uniprotkb:Macrophage MHC class I receptor 2 homolog(gene name synonym)	psi-mi:ub2v1_human(display_long)|uniprotkb:CROC-1(gene name synonym)|uniprotkb:TRAF6-regulated IKK activator 1 beta Uev1A(gene name synonym)|uniprotkb:P/OKcl.19(orf name)|uniprotkb:UBE2V1(gene name)|psi-mi:UBE2V1(display_short)|uniprotkb:CROC1(gene name synonym)|uniprotkb:UBE2V(gene name synonym)|uniprotkb:UEV1(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9970726|imex:IM-22822-39	author-confidence:Z-score = 7.63	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSP00000281416|ensembl:ENSP00000376141|refseq:XP_011509670.1|refseq:NP_060164.3|refseq:XP_005246711.1|ensembl:ENSG00000151690(gene)|ensembl:ENST00000281416(transcript)|ensembl:ENST00000392328(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0042590"(antigen processing and presentation of exogenous peptide antigen via MHC class I)|interpro:IPR024989|interpro:IPR036259	refseq:NP_001027459.1|refseq:NP_068823.2|refseq:NP_071887.1|refseq:NP_954595.1|refseq:NP_954673.1|refseq:NP_001244322.1|refseq:NP_001244323.1|refseq:NP_001244325.1|ensembl:ENSG00000244687(gene)|ensembl:ENST00000371674(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006282"(regulation of DNA repair)|go:"GO:0006301"(postreplication repair)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0030154"(cell differentiation)|go:"GO:0031371"(ubiquitin conjugating enzyme complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035370"(UBC13-UEV1A complex)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070534"(protein K63-linked ubiquitination)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|rcsb pdb:2A4D|rcsb pdb:2C2V|rcsb pdb:2HLW|rcsb pdb:6D6I|reactome:R-HSA-168638|reactome:R-HSA-168927|reactome:R-HSA-202424|reactome:R-HSA-2871837|reactome:R-HSA-445989|reactome:R-HSA-450302|reactome:R-HSA-450321|reactome:R-HSA-5607764|reactome:R-HSA-9020702|reactome:R-HSA-937039|reactome:R-HSA-937041|reactome:R-HSA-9646399|reactome:R-HSA-975110|reactome:R-HSA-975144|reactome:R-HSA-983168|dip:DIP-41911N	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S2|caution:"UBE2N has been marked as the enzyme in this assay, although it is the UBE2N-UBE2V1 complex that has ubiquitinase (E3) activity. Neither UBE2N nor UBE2V1 have E2 or E3 activity on their own."|resulting-ptm:Q6ZSS7 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:Fu3jyjX1ribBg4Uq5gMo7qWRUbk9606	rogid:x95N7Dj2KIqu5gySX59xLmfthUg9606	intact-crc:3704856A28E01DDD|rigid:PT+RrkOUZFpbp6qzfNOrRTDS4r0	false	-	his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q6ZSS7	uniprotkb:P22314	intact:EBI-2858252|uniprotkb:Q9NXM3|uniprotkb:D3KSZ4|uniprotkb:Q86TH2|ensembl:ENSP00000281416|ensembl:ENSP00000376141	intact:EBI-709688|uniprotkb:Q96E13|uniprotkb:Q5JRR8|ensembl:ENSP00000338413|ensembl:ENSP00000366568	psi-mi:mfsd6_human(display_long)|uniprotkb:MFSD6(gene name)|psi-mi:MFSD6(display_short)|uniprotkb:MMR2(gene name synonym)|uniprotkb:Macrophage MHC class I receptor 2 homolog(gene name synonym)	psi-mi:uba1_human(display_long)|uniprotkb:Ubiquitin-activating enzyme E1(gene name synonym)|uniprotkb:Protein A1S9(gene name synonym)|uniprotkb:UBA1(gene name)|psi-mi:UBA1(display_short)|uniprotkb:A1S9T(gene name synonym)|uniprotkb:UBE1(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9970726|imex:IM-22822-39	author-confidence:Z-score = 7.63	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSP00000281416|ensembl:ENSP00000376141|refseq:XP_011509670.1|refseq:NP_060164.3|refseq:XP_005246711.1|ensembl:ENSG00000151690(gene)|ensembl:ENST00000281416(transcript)|ensembl:ENST00000392328(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0042590"(antigen processing and presentation of exogenous peptide antigen via MHC class I)|interpro:IPR024989|interpro:IPR036259	refseq:NP_003325.2|refseq:NP_695012.1|refseq:XP_016885269.1|refseq:XP_016885270.1|dip:DIP-33686N|ensembl:ENSG00000130985(gene)|ensembl:ENST00000335972(transcript)|ensembl:ENST00000377351(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0004839"(ubiquitin activating enzyme activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0032446"(protein modification by small protein conjugation)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000011(Ubiquitin-activating enzyme, E1)|interpro:IPR000594(UBA/THIF-type NAD/FAD binding fold)|interpro:IPR018074|interpro:IPR018075|interpro:IPR018965|interpro:IPR019572|interpro:IPR032418|interpro:IPR032420|interpro:IPR033127|interpro:IPR035985|interpro:IPR038252|interpro:IPR042063|interpro:IPR042302|interpro:IPR042449|mint:P22314|rcsb pdb:4P22|rcsb pdb:6DC6|reactome:R-HSA-8866652|reactome:R-HSA-983168	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S2|caution:"UBE2N has been marked as the enzyme in this assay, although it is the UBE2N-UBE2V1 complex that has ubiquitinase (E3) activity. Neither UBE2N nor UBE2V1 have E2 or E3 activity on their own."|resulting-ptm:Q6ZSS7 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:Fu3jyjX1ribBg4Uq5gMo7qWRUbk9606	rogid:q+vEeA0XLST0Zz173bmEt0dNbDE9606	intact-crc:3704856A28E01DDD|rigid:PT+RrkOUZFpbp6qzfNOrRTDS4r0	false	-	his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q6ZSS7	uniprotkb:P61088	intact:EBI-2858252|uniprotkb:Q9NXM3|uniprotkb:D3KSZ4|uniprotkb:Q86TH2|ensembl:ENSP00000281416|ensembl:ENSP00000376141	intact:EBI-1052908|uniprotkb:Q16781|uniprotkb:Q53Y81|ensembl:ENSP00000316176	psi-mi:mfsd6_human(display_long)|uniprotkb:MFSD6(gene name)|psi-mi:MFSD6(display_short)|uniprotkb:MMR2(gene name synonym)|uniprotkb:Macrophage MHC class I receptor 2 homolog(gene name synonym)	psi-mi:ube2n_human(display_long)|uniprotkb:Ubiquitin-protein ligase N(gene name synonym)|uniprotkb:Ubiquitin carrier protein N(gene name synonym)|uniprotkb:Ubc13(gene name synonym)|uniprotkb:Bendless-like ubiquitin-conjugating enzyme(gene name synonym)|uniprotkb:UBE2N(gene name)|psi-mi:UBE2N(display_short)|uniprotkb:BLU(gene name synonym)|uniprotkb:UbcH13(gene name synonym)|uniprotkb:E2 ubiquitin-conjugating enzyme N(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9970726|imex:IM-22822-39	author-confidence:Z-score = 7.63	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSP00000281416|ensembl:ENSP00000376141|refseq:XP_011509670.1|refseq:NP_060164.3|refseq:XP_005246711.1|ensembl:ENSG00000151690(gene)|ensembl:ENST00000281416(transcript)|ensembl:ENST00000392328(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0042590"(antigen processing and presentation of exogenous peptide antigen via MHC class I)|interpro:IPR024989|interpro:IPR036259	refseq:NP_003339.1|dip:DIP-29829N|ensembl:ENSG00000177889(gene)|ensembl:ENST00000318066(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000729"(DNA double-strand break processing)|go:"GO:0001650"(fibrillar center)|go:"GO:0003723"(RNA binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006282"(regulation of DNA repair)|go:"GO:0006301"(postreplication repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016574"(histone ubiquitination)|go:"GO:0031058"(positive regulation of histone modification)|go:"GO:0031372"(UBC13-MMS2 complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033182"(regulation of histone ubiquitination)|go:"GO:0035370"(UBC13-UEV1A complex)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0061631"(ubiquitin conjugating enzyme activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070534"(protein K63-linked ubiquitination)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|interpro:IPR023313|rcsb pdb:1J7D|rcsb pdb:2C2V|rcsb pdb:3HCT|rcsb pdb:3HCU|rcsb pdb:3VON|rcsb pdb:3W31|rcsb pdb:4DHI|rcsb pdb:4DHJ|rcsb pdb:4DHZ|rcsb pdb:4IP3|rcsb pdb:4NR3|rcsb pdb:4NRG|rcsb pdb:4NRI|rcsb pdb:4ONL|rcsb pdb:4ONM|rcsb pdb:4ONN|rcsb pdb:4ORH|rcsb pdb:4TKP|rcsb pdb:4WHV|rcsb pdb:5AIT|rcsb pdb:5AIU|rcsb pdb:5EYA|rcsb pdb:5H7S|rcsb pdb:5VNZ|rcsb pdb:5VO0|rcsb pdb:5YWR|rcsb pdb:6D6I|rcsb pdb:6JKY|rcsb pdb:6KFP|rcsb pdb:6KG6|rcsb pdb:6KL4|rcsb pdb:6LP2|rcsb pdb:6P5B|rcsb pdb:6S53|reactome:R-HSA-168927|reactome:R-HSA-202424|reactome:R-HSA-2871837|reactome:R-HSA-445989|reactome:R-HSA-450302|reactome:R-HSA-450321|reactome:R-HSA-5607764|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-5696395|reactome:R-HSA-69473|reactome:R-HSA-8866654|reactome:R-HSA-9020702|reactome:R-HSA-937039|reactome:R-HSA-937041|reactome:R-HSA-9646399|reactome:R-HSA-975110|reactome:R-HSA-975144|reactome:R-HSA-983168|rcsb pdb:6ULH|rcsb pdb:6UMP|rcsb pdb:6UMS|rcsb pdb:7BBD|rcsb pdb:7BBF|rcsb pdb:7BXG|reactome:R-HSA-1169408|reactome:R-HSA-168638	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S2|caution:"UBE2N has been marked as the enzyme in this assay, although it is the UBE2N-UBE2V1 complex that has ubiquitinase (E3) activity. Neither UBE2N nor UBE2V1 have E2 or E3 activity on their own."|resulting-ptm:Q6ZSS7 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:Fu3jyjX1ribBg4Uq5gMo7qWRUbk9606	rogid:dqdszHlq5FLPHC6UWX6uvkC6Yz89606	intact-crc:3704856A28E01DDD|rigid:PT+RrkOUZFpbp6qzfNOrRTDS4r0	false	-	his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q6ZNA4	uniprotkb:Q13404	intact:EBI-2129175|uniprotkb:Q6ZMU2|uniprotkb:Q7L428|uniprotkb:Q7Z346|uniprotkb:Q8N1P9|uniprotkb:Q8WUA3|uniprotkb:Q9NSR1|uniprotkb:Q6P9A4|uniprotkb:C9JUS4|uniprotkb:H0YN55|ensembl:ENSP00000452732|intact:EBI-28970158	intact:EBI-1050671|uniprotkb:Q13403|uniprotkb:Q13532|uniprotkb:Q96H34|uniprotkb:Q9GZT0|uniprotkb:Q9GZW1|uniprotkb:Q9H4J3|uniprotkb:Q9H4J4|uniprotkb:Q9UKL1|uniprotkb:Q9UM48|uniprotkb:Q9UM49|uniprotkb:Q9UM50|uniprotkb:Q5TGE3|uniprotkb:E1P629|uniprotkb:Q5TGE0|ensembl:ENSP00000360739	psi-mi:rn111_human(display_long)|uniprotkb:RNF111(gene name)|psi-mi:RNF111(display_short)|uniprotkb:RING finger protein 111(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase Arkadia(gene name synonym)	psi-mi:ub2v1_human(display_long)|uniprotkb:CROC-1(gene name synonym)|uniprotkb:TRAF6-regulated IKK activator 1 beta Uev1A(gene name synonym)|uniprotkb:P/OKcl.19(orf name)|uniprotkb:UBE2V1(gene name)|psi-mi:UBE2V1(display_short)|uniprotkb:CROC1(gene name synonym)|uniprotkb:UBE2V(gene name synonym)|uniprotkb:UEV1(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9970705|imex:IM-22822-38	author-confidence:Z-score = 18.65	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_060080.6|ensembl:ENST00000348370|ensembl:ENSP00000288199|ensembl:ENSP00000452732|ensembl:ENST00000559209|ensembl:ENSP00000453872|ensembl:ENST00000561186|ensembl:ENSP00000453015|refseq:NP_001317260.1|refseq:XP_016877827.1|refseq:XP_006720642.1|refseq:NP_001257459.1|refseq:NP_001257457.1|refseq:NP_001257458.1|ensembl:ENSG00000157450(gene)|ensembl:ENST00000557998(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0007389"(pattern specification process)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016605"(PML body)|go:"GO:0030511"(positive regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030579"(ubiquitin-dependent SMAD protein catabolic process)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032991"(protein-containing complex)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046332"(SMAD binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070911"(global genome nucleotide-excision repair)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR029306|rcsb pdb:2KIZ|rcsb pdb:5LG0|rcsb pdb:5LG7|reactome:R-HSA-2173795|reactome:R-HSA-2173796|reactome:R-HSA-5696395|reactome:R-HSA-983168|go:"GO:0032184"(SUMO polymer binding)	refseq:NP_001027459.1|refseq:NP_068823.2|refseq:NP_071887.1|refseq:NP_954595.1|refseq:NP_954673.1|refseq:NP_001244322.1|refseq:NP_001244323.1|refseq:NP_001244325.1|ensembl:ENSG00000244687(gene)|ensembl:ENST00000371674(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006282"(regulation of DNA repair)|go:"GO:0006301"(postreplication repair)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0030154"(cell differentiation)|go:"GO:0031371"(ubiquitin conjugating enzyme complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035370"(UBC13-UEV1A complex)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070534"(protein K63-linked ubiquitination)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|rcsb pdb:2A4D|rcsb pdb:2C2V|rcsb pdb:2HLW|rcsb pdb:6D6I|reactome:R-HSA-168638|reactome:R-HSA-168927|reactome:R-HSA-202424|reactome:R-HSA-2871837|reactome:R-HSA-445989|reactome:R-HSA-450302|reactome:R-HSA-450321|reactome:R-HSA-5607764|reactome:R-HSA-9020702|reactome:R-HSA-937039|reactome:R-HSA-937041|reactome:R-HSA-9646399|reactome:R-HSA-975110|reactome:R-HSA-975144|reactome:R-HSA-983168|dip:DIP-41911N	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S2|caution:"UBE2N has been marked as the enzyme in this assay, although it is the UBE2N-UBE2V1 complex that has ubiquitinase (E3) activity. Neither UBE2N nor UBE2V1 have E2 or E3 activity on their own."|resulting-ptm:Q6ZNA4 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:6SY5oMr5u4mnVi+zdRboVljMGa09606	rogid:x95N7Dj2KIqu5gySX59xLmfthUg9606	intact-crc:2EC3C5525F843EA6|rigid:AEAM6x8TJyMzRERmSpn/8h9UlYE	false	-	his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q6ZNA4	uniprotkb:P22314	intact:EBI-2129175|uniprotkb:Q6ZMU2|uniprotkb:Q7L428|uniprotkb:Q7Z346|uniprotkb:Q8N1P9|uniprotkb:Q8WUA3|uniprotkb:Q9NSR1|uniprotkb:Q6P9A4|uniprotkb:C9JUS4|uniprotkb:H0YN55|ensembl:ENSP00000452732|intact:EBI-28970158	intact:EBI-709688|uniprotkb:Q96E13|uniprotkb:Q5JRR8|ensembl:ENSP00000338413|ensembl:ENSP00000366568	psi-mi:rn111_human(display_long)|uniprotkb:RNF111(gene name)|psi-mi:RNF111(display_short)|uniprotkb:RING finger protein 111(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase Arkadia(gene name synonym)	psi-mi:uba1_human(display_long)|uniprotkb:Ubiquitin-activating enzyme E1(gene name synonym)|uniprotkb:Protein A1S9(gene name synonym)|uniprotkb:UBA1(gene name)|psi-mi:UBA1(display_short)|uniprotkb:A1S9T(gene name synonym)|uniprotkb:UBE1(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9970705|imex:IM-22822-38	author-confidence:Z-score = 18.65	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_060080.6|ensembl:ENST00000348370|ensembl:ENSP00000288199|ensembl:ENSP00000452732|ensembl:ENST00000559209|ensembl:ENSP00000453872|ensembl:ENST00000561186|ensembl:ENSP00000453015|refseq:NP_001317260.1|refseq:XP_016877827.1|refseq:XP_006720642.1|refseq:NP_001257459.1|refseq:NP_001257457.1|refseq:NP_001257458.1|ensembl:ENSG00000157450(gene)|ensembl:ENST00000557998(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0007389"(pattern specification process)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016605"(PML body)|go:"GO:0030511"(positive regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030579"(ubiquitin-dependent SMAD protein catabolic process)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032991"(protein-containing complex)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046332"(SMAD binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070911"(global genome nucleotide-excision repair)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR029306|rcsb pdb:2KIZ|rcsb pdb:5LG0|rcsb pdb:5LG7|reactome:R-HSA-2173795|reactome:R-HSA-2173796|reactome:R-HSA-5696395|reactome:R-HSA-983168|go:"GO:0032184"(SUMO polymer binding)	refseq:NP_003325.2|refseq:NP_695012.1|refseq:XP_016885269.1|refseq:XP_016885270.1|dip:DIP-33686N|ensembl:ENSG00000130985(gene)|ensembl:ENST00000335972(transcript)|ensembl:ENST00000377351(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0004839"(ubiquitin activating enzyme activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0032446"(protein modification by small protein conjugation)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000011(Ubiquitin-activating enzyme, E1)|interpro:IPR000594(UBA/THIF-type NAD/FAD binding fold)|interpro:IPR018074|interpro:IPR018075|interpro:IPR018965|interpro:IPR019572|interpro:IPR032418|interpro:IPR032420|interpro:IPR033127|interpro:IPR035985|interpro:IPR038252|interpro:IPR042063|interpro:IPR042302|interpro:IPR042449|mint:P22314|rcsb pdb:4P22|rcsb pdb:6DC6|reactome:R-HSA-8866652|reactome:R-HSA-983168	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S2|caution:"UBE2N has been marked as the enzyme in this assay, although it is the UBE2N-UBE2V1 complex that has ubiquitinase (E3) activity. Neither UBE2N nor UBE2V1 have E2 or E3 activity on their own."|resulting-ptm:Q6ZNA4 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:6SY5oMr5u4mnVi+zdRboVljMGa09606	rogid:q+vEeA0XLST0Zz173bmEt0dNbDE9606	intact-crc:2EC3C5525F843EA6|rigid:AEAM6x8TJyMzRERmSpn/8h9UlYE	false	-	his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q6ZNA4	uniprotkb:P61088	intact:EBI-2129175|uniprotkb:Q6ZMU2|uniprotkb:Q7L428|uniprotkb:Q7Z346|uniprotkb:Q8N1P9|uniprotkb:Q8WUA3|uniprotkb:Q9NSR1|uniprotkb:Q6P9A4|uniprotkb:C9JUS4|uniprotkb:H0YN55|ensembl:ENSP00000452732|intact:EBI-28970158	intact:EBI-1052908|uniprotkb:Q16781|uniprotkb:Q53Y81|ensembl:ENSP00000316176	psi-mi:rn111_human(display_long)|uniprotkb:RNF111(gene name)|psi-mi:RNF111(display_short)|uniprotkb:RING finger protein 111(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase Arkadia(gene name synonym)	psi-mi:ube2n_human(display_long)|uniprotkb:Ubiquitin-protein ligase N(gene name synonym)|uniprotkb:Ubiquitin carrier protein N(gene name synonym)|uniprotkb:Ubc13(gene name synonym)|uniprotkb:Bendless-like ubiquitin-conjugating enzyme(gene name synonym)|uniprotkb:UBE2N(gene name)|psi-mi:UBE2N(display_short)|uniprotkb:BLU(gene name synonym)|uniprotkb:UbcH13(gene name synonym)|uniprotkb:E2 ubiquitin-conjugating enzyme N(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9970705|imex:IM-22822-38	author-confidence:Z-score = 18.65	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_060080.6|ensembl:ENST00000348370|ensembl:ENSP00000288199|ensembl:ENSP00000452732|ensembl:ENST00000559209|ensembl:ENSP00000453872|ensembl:ENST00000561186|ensembl:ENSP00000453015|refseq:NP_001317260.1|refseq:XP_016877827.1|refseq:XP_006720642.1|refseq:NP_001257459.1|refseq:NP_001257457.1|refseq:NP_001257458.1|ensembl:ENSG00000157450(gene)|ensembl:ENST00000557998(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0007389"(pattern specification process)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016605"(PML body)|go:"GO:0030511"(positive regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030579"(ubiquitin-dependent SMAD protein catabolic process)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032991"(protein-containing complex)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046332"(SMAD binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070911"(global genome nucleotide-excision repair)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR029306|rcsb pdb:2KIZ|rcsb pdb:5LG0|rcsb pdb:5LG7|reactome:R-HSA-2173795|reactome:R-HSA-2173796|reactome:R-HSA-5696395|reactome:R-HSA-983168|go:"GO:0032184"(SUMO polymer binding)	refseq:NP_003339.1|dip:DIP-29829N|ensembl:ENSG00000177889(gene)|ensembl:ENST00000318066(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000729"(DNA double-strand break processing)|go:"GO:0001650"(fibrillar center)|go:"GO:0003723"(RNA binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006282"(regulation of DNA repair)|go:"GO:0006301"(postreplication repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016574"(histone ubiquitination)|go:"GO:0031058"(positive regulation of histone modification)|go:"GO:0031372"(UBC13-MMS2 complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033182"(regulation of histone ubiquitination)|go:"GO:0035370"(UBC13-UEV1A complex)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0061631"(ubiquitin conjugating enzyme activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070534"(protein K63-linked ubiquitination)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|interpro:IPR023313|rcsb pdb:1J7D|rcsb pdb:2C2V|rcsb pdb:3HCT|rcsb pdb:3HCU|rcsb pdb:3VON|rcsb pdb:3W31|rcsb pdb:4DHI|rcsb pdb:4DHJ|rcsb pdb:4DHZ|rcsb pdb:4IP3|rcsb pdb:4NR3|rcsb pdb:4NRG|rcsb pdb:4NRI|rcsb pdb:4ONL|rcsb pdb:4ONM|rcsb pdb:4ONN|rcsb pdb:4ORH|rcsb pdb:4TKP|rcsb pdb:4WHV|rcsb pdb:5AIT|rcsb pdb:5AIU|rcsb pdb:5EYA|rcsb pdb:5H7S|rcsb pdb:5VNZ|rcsb pdb:5VO0|rcsb pdb:5YWR|rcsb pdb:6D6I|rcsb pdb:6JKY|rcsb pdb:6KFP|rcsb pdb:6KG6|rcsb pdb:6KL4|rcsb pdb:6LP2|rcsb pdb:6P5B|rcsb pdb:6S53|reactome:R-HSA-168927|reactome:R-HSA-202424|reactome:R-HSA-2871837|reactome:R-HSA-445989|reactome:R-HSA-450302|reactome:R-HSA-450321|reactome:R-HSA-5607764|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-5696395|reactome:R-HSA-69473|reactome:R-HSA-8866654|reactome:R-HSA-9020702|reactome:R-HSA-937039|reactome:R-HSA-937041|reactome:R-HSA-9646399|reactome:R-HSA-975110|reactome:R-HSA-975144|reactome:R-HSA-983168|rcsb pdb:6ULH|rcsb pdb:6UMP|rcsb pdb:6UMS|rcsb pdb:7BBD|rcsb pdb:7BBF|rcsb pdb:7BXG|reactome:R-HSA-1169408|reactome:R-HSA-168638	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S2|caution:"UBE2N has been marked as the enzyme in this assay, although it is the UBE2N-UBE2V1 complex that has ubiquitinase (E3) activity. Neither UBE2N nor UBE2V1 have E2 or E3 activity on their own."|resulting-ptm:Q6ZNA4 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:6SY5oMr5u4mnVi+zdRboVljMGa09606	rogid:dqdszHlq5FLPHC6UWX6uvkC6Yz89606	intact-crc:2EC3C5525F843EA6|rigid:AEAM6x8TJyMzRERmSpn/8h9UlYE	false	-	his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q6UWE0	uniprotkb:Q13404	intact:EBI-720984|uniprotkb:Q5VVV0|uniprotkb:Q8NB40|uniprotkb:Q96GT5|uniprotkb:Q96MX5|uniprotkb:Q96MZ7|ensembl:ENSP00000300417|ensembl:ENSP00000322937|ensembl:ENSP00000362419|ensembl:ENSP00000502167	intact:EBI-1050671|uniprotkb:Q13403|uniprotkb:Q13532|uniprotkb:Q96H34|uniprotkb:Q9GZT0|uniprotkb:Q9GZW1|uniprotkb:Q9H4J3|uniprotkb:Q9H4J4|uniprotkb:Q9UKL1|uniprotkb:Q9UM48|uniprotkb:Q9UM49|uniprotkb:Q9UM50|uniprotkb:Q5TGE3|uniprotkb:E1P629|uniprotkb:Q5TGE0|ensembl:ENSP00000360739	psi-mi:lrsm1_human(display_long)|uniprotkb:Leucine-rich repeat and sterile alpha motif-containing protein 1(gene name synonym)|uniprotkb:Tsg101-associated ligase(gene name synonym)|uniprotkb:LRSAM1(gene name)|psi-mi:LRSAM1(display_short)|uniprotkb:TAL(gene name synonym)|uniprotkb:UNQ6496/PRO21356(orf name)|uniprotkb:RING-type E3 ubiquitin transferase LRSAM1(gene name synonym)	psi-mi:ub2v1_human(display_long)|uniprotkb:CROC-1(gene name synonym)|uniprotkb:TRAF6-regulated IKK activator 1 beta Uev1A(gene name synonym)|uniprotkb:P/OKcl.19(orf name)|uniprotkb:UBE2V1(gene name)|psi-mi:UBE2V1(display_short)|uniprotkb:CROC1(gene name synonym)|uniprotkb:UBE2V(gene name synonym)|uniprotkb:UEV1(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9970683|imex:IM-22822-37	author-confidence:Z-score = 14.79|author-confidence:Z-score = 15.96	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001005373.1|refseq:NP_001005374.1|refseq:NP_001177652.1|refseq:NP_612370.3|refseq:XP_016870772.1|ensembl:ENSG00000148356(gene)|ensembl:ENST00000300417(transcript)|ensembl:ENST00000323301(transcript)|ensembl:ENST00000373322(transcript)|ensembl:ENST00000675448(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006914"(autophagy)|go:"GO:0016020"(membrane)|go:"GO:0030163"(protein catabolic process)|go:"GO:0045806"(negative regulation of endocytosis)|go:"GO:0046755"(viral budding)|go:"GO:0046872"(metal ion binding)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070086"(ubiquitin-dependent endocytosis)|go:"GO:1904417"(positive regulation of xenophagy)|go:"GO:2000786"(positive regulation of autophagosome assembly)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR032675|mint:Q6UWE0|reactome:R-HSA-983168	refseq:NP_001027459.1|refseq:NP_068823.2|refseq:NP_071887.1|refseq:NP_954595.1|refseq:NP_954673.1|refseq:NP_001244322.1|refseq:NP_001244323.1|refseq:NP_001244325.1|ensembl:ENSG00000244687(gene)|ensembl:ENST00000371674(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006282"(regulation of DNA repair)|go:"GO:0006301"(postreplication repair)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0030154"(cell differentiation)|go:"GO:0031371"(ubiquitin conjugating enzyme complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035370"(UBC13-UEV1A complex)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070534"(protein K63-linked ubiquitination)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|rcsb pdb:2A4D|rcsb pdb:2C2V|rcsb pdb:2HLW|rcsb pdb:6D6I|reactome:R-HSA-168638|reactome:R-HSA-168927|reactome:R-HSA-202424|reactome:R-HSA-2871837|reactome:R-HSA-445989|reactome:R-HSA-450302|reactome:R-HSA-450321|reactome:R-HSA-5607764|reactome:R-HSA-9020702|reactome:R-HSA-937039|reactome:R-HSA-937041|reactome:R-HSA-9646399|reactome:R-HSA-975110|reactome:R-HSA-975144|reactome:R-HSA-983168|dip:DIP-41911N	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S2|caution:"UBE2N has been marked as the enzyme in this assay, although it is the UBE2N-UBE2V1 complex that has ubiquitinase (E3) activity. Neither UBE2N nor UBE2V1 have E2 or E3 activity on their own."|resulting-ptm:Q6UWE0 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:qkwPqOsfNjZBB2Xp6YAA9FbEZxM9606	rogid:x95N7Dj2KIqu5gySX59xLmfthUg9606	intact-crc:B4D6941C0144EB38|rigid:fxbW6ohGNIO/Ar4o5O51Q/xuzH4	false	-	his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q6UWE0	uniprotkb:P22314	intact:EBI-720984|uniprotkb:Q5VVV0|uniprotkb:Q8NB40|uniprotkb:Q96GT5|uniprotkb:Q96MX5|uniprotkb:Q96MZ7|ensembl:ENSP00000300417|ensembl:ENSP00000322937|ensembl:ENSP00000362419|ensembl:ENSP00000502167	intact:EBI-709688|uniprotkb:Q96E13|uniprotkb:Q5JRR8|ensembl:ENSP00000338413|ensembl:ENSP00000366568	psi-mi:lrsm1_human(display_long)|uniprotkb:Leucine-rich repeat and sterile alpha motif-containing protein 1(gene name synonym)|uniprotkb:Tsg101-associated ligase(gene name synonym)|uniprotkb:LRSAM1(gene name)|psi-mi:LRSAM1(display_short)|uniprotkb:TAL(gene name synonym)|uniprotkb:UNQ6496/PRO21356(orf name)|uniprotkb:RING-type E3 ubiquitin transferase LRSAM1(gene name synonym)	psi-mi:uba1_human(display_long)|uniprotkb:Ubiquitin-activating enzyme E1(gene name synonym)|uniprotkb:Protein A1S9(gene name synonym)|uniprotkb:UBA1(gene name)|psi-mi:UBA1(display_short)|uniprotkb:A1S9T(gene name synonym)|uniprotkb:UBE1(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9970683|imex:IM-22822-37	author-confidence:Z-score = 14.79|author-confidence:Z-score = 15.96	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001005373.1|refseq:NP_001005374.1|refseq:NP_001177652.1|refseq:NP_612370.3|refseq:XP_016870772.1|ensembl:ENSG00000148356(gene)|ensembl:ENST00000300417(transcript)|ensembl:ENST00000323301(transcript)|ensembl:ENST00000373322(transcript)|ensembl:ENST00000675448(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006914"(autophagy)|go:"GO:0016020"(membrane)|go:"GO:0030163"(protein catabolic process)|go:"GO:0045806"(negative regulation of endocytosis)|go:"GO:0046755"(viral budding)|go:"GO:0046872"(metal ion binding)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070086"(ubiquitin-dependent endocytosis)|go:"GO:1904417"(positive regulation of xenophagy)|go:"GO:2000786"(positive regulation of autophagosome assembly)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR032675|mint:Q6UWE0|reactome:R-HSA-983168	refseq:NP_003325.2|refseq:NP_695012.1|refseq:XP_016885269.1|refseq:XP_016885270.1|dip:DIP-33686N|ensembl:ENSG00000130985(gene)|ensembl:ENST00000335972(transcript)|ensembl:ENST00000377351(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0004839"(ubiquitin activating enzyme activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0032446"(protein modification by small protein conjugation)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000011(Ubiquitin-activating enzyme, E1)|interpro:IPR000594(UBA/THIF-type NAD/FAD binding fold)|interpro:IPR018074|interpro:IPR018075|interpro:IPR018965|interpro:IPR019572|interpro:IPR032418|interpro:IPR032420|interpro:IPR033127|interpro:IPR035985|interpro:IPR038252|interpro:IPR042063|interpro:IPR042302|interpro:IPR042449|mint:P22314|rcsb pdb:4P22|rcsb pdb:6DC6|reactome:R-HSA-8866652|reactome:R-HSA-983168	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S2|caution:"UBE2N has been marked as the enzyme in this assay, although it is the UBE2N-UBE2V1 complex that has ubiquitinase (E3) activity. Neither UBE2N nor UBE2V1 have E2 or E3 activity on their own."|resulting-ptm:Q6UWE0 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:qkwPqOsfNjZBB2Xp6YAA9FbEZxM9606	rogid:q+vEeA0XLST0Zz173bmEt0dNbDE9606	intact-crc:B4D6941C0144EB38|rigid:fxbW6ohGNIO/Ar4o5O51Q/xuzH4	false	-	his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q6UWE0	uniprotkb:P61088	intact:EBI-720984|uniprotkb:Q5VVV0|uniprotkb:Q8NB40|uniprotkb:Q96GT5|uniprotkb:Q96MX5|uniprotkb:Q96MZ7|ensembl:ENSP00000300417|ensembl:ENSP00000322937|ensembl:ENSP00000362419|ensembl:ENSP00000502167	intact:EBI-1052908|uniprotkb:Q16781|uniprotkb:Q53Y81|ensembl:ENSP00000316176	psi-mi:lrsm1_human(display_long)|uniprotkb:Leucine-rich repeat and sterile alpha motif-containing protein 1(gene name synonym)|uniprotkb:Tsg101-associated ligase(gene name synonym)|uniprotkb:LRSAM1(gene name)|psi-mi:LRSAM1(display_short)|uniprotkb:TAL(gene name synonym)|uniprotkb:UNQ6496/PRO21356(orf name)|uniprotkb:RING-type E3 ubiquitin transferase LRSAM1(gene name synonym)	psi-mi:ube2n_human(display_long)|uniprotkb:Ubiquitin-protein ligase N(gene name synonym)|uniprotkb:Ubiquitin carrier protein N(gene name synonym)|uniprotkb:Ubc13(gene name synonym)|uniprotkb:Bendless-like ubiquitin-conjugating enzyme(gene name synonym)|uniprotkb:UBE2N(gene name)|psi-mi:UBE2N(display_short)|uniprotkb:BLU(gene name synonym)|uniprotkb:UbcH13(gene name synonym)|uniprotkb:E2 ubiquitin-conjugating enzyme N(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9970683|imex:IM-22822-37	author-confidence:Z-score = 14.79|author-confidence:Z-score = 15.96	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001005373.1|refseq:NP_001005374.1|refseq:NP_001177652.1|refseq:NP_612370.3|refseq:XP_016870772.1|ensembl:ENSG00000148356(gene)|ensembl:ENST00000300417(transcript)|ensembl:ENST00000323301(transcript)|ensembl:ENST00000373322(transcript)|ensembl:ENST00000675448(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006914"(autophagy)|go:"GO:0016020"(membrane)|go:"GO:0030163"(protein catabolic process)|go:"GO:0045806"(negative regulation of endocytosis)|go:"GO:0046755"(viral budding)|go:"GO:0046872"(metal ion binding)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070086"(ubiquitin-dependent endocytosis)|go:"GO:1904417"(positive regulation of xenophagy)|go:"GO:2000786"(positive regulation of autophagosome assembly)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR032675|mint:Q6UWE0|reactome:R-HSA-983168	refseq:NP_003339.1|dip:DIP-29829N|ensembl:ENSG00000177889(gene)|ensembl:ENST00000318066(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000729"(DNA double-strand break processing)|go:"GO:0001650"(fibrillar center)|go:"GO:0003723"(RNA binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006282"(regulation of DNA repair)|go:"GO:0006301"(postreplication repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016574"(histone ubiquitination)|go:"GO:0031058"(positive regulation of histone modification)|go:"GO:0031372"(UBC13-MMS2 complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033182"(regulation of histone ubiquitination)|go:"GO:0035370"(UBC13-UEV1A complex)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0061631"(ubiquitin conjugating enzyme activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070534"(protein K63-linked ubiquitination)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|interpro:IPR023313|rcsb pdb:1J7D|rcsb pdb:2C2V|rcsb pdb:3HCT|rcsb pdb:3HCU|rcsb pdb:3VON|rcsb pdb:3W31|rcsb pdb:4DHI|rcsb pdb:4DHJ|rcsb pdb:4DHZ|rcsb pdb:4IP3|rcsb pdb:4NR3|rcsb pdb:4NRG|rcsb pdb:4NRI|rcsb pdb:4ONL|rcsb pdb:4ONM|rcsb pdb:4ONN|rcsb pdb:4ORH|rcsb pdb:4TKP|rcsb pdb:4WHV|rcsb pdb:5AIT|rcsb pdb:5AIU|rcsb pdb:5EYA|rcsb pdb:5H7S|rcsb pdb:5VNZ|rcsb pdb:5VO0|rcsb pdb:5YWR|rcsb pdb:6D6I|rcsb pdb:6JKY|rcsb pdb:6KFP|rcsb pdb:6KG6|rcsb pdb:6KL4|rcsb pdb:6LP2|rcsb pdb:6P5B|rcsb pdb:6S53|reactome:R-HSA-168927|reactome:R-HSA-202424|reactome:R-HSA-2871837|reactome:R-HSA-445989|reactome:R-HSA-450302|reactome:R-HSA-450321|reactome:R-HSA-5607764|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-5696395|reactome:R-HSA-69473|reactome:R-HSA-8866654|reactome:R-HSA-9020702|reactome:R-HSA-937039|reactome:R-HSA-937041|reactome:R-HSA-9646399|reactome:R-HSA-975110|reactome:R-HSA-975144|reactome:R-HSA-983168|rcsb pdb:6ULH|rcsb pdb:6UMP|rcsb pdb:6UMS|rcsb pdb:7BBD|rcsb pdb:7BBF|rcsb pdb:7BXG|reactome:R-HSA-1169408|reactome:R-HSA-168638	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S2|caution:"UBE2N has been marked as the enzyme in this assay, although it is the UBE2N-UBE2V1 complex that has ubiquitinase (E3) activity. Neither UBE2N nor UBE2V1 have E2 or E3 activity on their own."|resulting-ptm:Q6UWE0 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:qkwPqOsfNjZBB2Xp6YAA9FbEZxM9606	rogid:dqdszHlq5FLPHC6UWX6uvkC6Yz89606	intact-crc:B4D6941C0144EB38|rigid:fxbW6ohGNIO/Ar4o5O51Q/xuzH4	false	-	his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q6ZWZ2	uniprotkb:Q13404	intact:EBI-8587051|ensembl:ENSMUSP00000038813|uniprotkb:Q8BW18|uniprotkb:Q8VDE5|intact:MINT-4609410	intact:EBI-1050671|uniprotkb:Q13403|uniprotkb:Q13532|uniprotkb:Q96H34|uniprotkb:Q9GZT0|uniprotkb:Q9GZW1|uniprotkb:Q9H4J3|uniprotkb:Q9H4J4|uniprotkb:Q9UKL1|uniprotkb:Q9UM48|uniprotkb:Q9UM49|uniprotkb:Q9UM50|uniprotkb:Q5TGE3|uniprotkb:E1P629|uniprotkb:Q5TGE0|ensembl:ENSP00000360739	psi-mi:ub2r2_mouse(display_long)|uniprotkb:Ube2r2(gene name)|psi-mi:Ube2r2(display_short)|uniprotkb:Cdc34b(gene name synonym)|uniprotkb:Ubc3b(gene name synonym)|uniprotkb:Ubiquitin-protein ligase R2(gene name synonym)|uniprotkb:Ubiquitin carrier protein R2(gene name synonym)|uniprotkb:Ubiquitin-conjugating enzyme E2-CDC34B(gene name synonym)|uniprotkb:E2 ubiquitin-conjugating enzyme R2(gene name synonym)	psi-mi:ub2v1_human(display_long)|uniprotkb:CROC-1(gene name synonym)|uniprotkb:TRAF6-regulated IKK activator 1 beta Uev1A(gene name synonym)|uniprotkb:P/OKcl.19(orf name)|uniprotkb:UBE2V1(gene name)|psi-mi:UBE2V1(display_short)|uniprotkb:CROC1(gene name synonym)|uniprotkb:UBE2V(gene name synonym)|uniprotkb:UEV1(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9970768|imex:IM-22822-41	author-confidence:Z-score = 3.63	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000036241(gene)|ensembl:ENSMUST00000040008(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0061631"(ubiquitin conjugating enzyme activity)|go:"GO:0070936"(protein K48-linked ubiquitination)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|go:"GO:0006513"(protein monoubiquitination)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|interpro:IPR023313|reactome:R-MMU-8866652|reactome:R-MMU-983168|refseq:NP_080551.1	refseq:NP_001027459.1|refseq:NP_068823.2|refseq:NP_071887.1|refseq:NP_954595.1|refseq:NP_954673.1|refseq:NP_001244322.1|refseq:NP_001244323.1|refseq:NP_001244325.1|ensembl:ENSG00000244687(gene)|ensembl:ENST00000371674(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006282"(regulation of DNA repair)|go:"GO:0006301"(postreplication repair)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0030154"(cell differentiation)|go:"GO:0031371"(ubiquitin conjugating enzyme complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035370"(UBC13-UEV1A complex)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070534"(protein K63-linked ubiquitination)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|rcsb pdb:2A4D|rcsb pdb:2C2V|rcsb pdb:2HLW|rcsb pdb:6D6I|reactome:R-HSA-168638|reactome:R-HSA-168927|reactome:R-HSA-202424|reactome:R-HSA-2871837|reactome:R-HSA-445989|reactome:R-HSA-450302|reactome:R-HSA-450321|reactome:R-HSA-5607764|reactome:R-HSA-9020702|reactome:R-HSA-937039|reactome:R-HSA-937041|reactome:R-HSA-9646399|reactome:R-HSA-975110|reactome:R-HSA-975144|reactome:R-HSA-983168|dip:DIP-41911N	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	comment:mint|function:Catalyzes the covalent attachment of ubiquitin to other proteins. May be involved in degradation of katenin	-	figure legend:Table S2|caution:"UBE2N has been marked as the enzyme in this assay, although it is the UBE2N-UBE2V1 complex that has ubiquitinase (E3) activity. Neither UBE2N nor UBE2V1 have E2 or E3 activity on their own."|resulting-ptm:Q6ZWZ2 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:fFTiply+7nUD6veFiQW5xcNmRrE10090	rogid:x95N7Dj2KIqu5gySX59xLmfthUg9606	intact-crc:EDDB90584F023AEB|rigid:chd87EN8mssccq7gKy54JfEpTAs	false	-	his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q6ZWZ2	uniprotkb:P22314	intact:EBI-8587051|ensembl:ENSMUSP00000038813|uniprotkb:Q8BW18|uniprotkb:Q8VDE5|intact:MINT-4609410	intact:EBI-709688|uniprotkb:Q96E13|uniprotkb:Q5JRR8|ensembl:ENSP00000338413|ensembl:ENSP00000366568	psi-mi:ub2r2_mouse(display_long)|uniprotkb:Ube2r2(gene name)|psi-mi:Ube2r2(display_short)|uniprotkb:Cdc34b(gene name synonym)|uniprotkb:Ubc3b(gene name synonym)|uniprotkb:Ubiquitin-protein ligase R2(gene name synonym)|uniprotkb:Ubiquitin carrier protein R2(gene name synonym)|uniprotkb:Ubiquitin-conjugating enzyme E2-CDC34B(gene name synonym)|uniprotkb:E2 ubiquitin-conjugating enzyme R2(gene name synonym)	psi-mi:uba1_human(display_long)|uniprotkb:Ubiquitin-activating enzyme E1(gene name synonym)|uniprotkb:Protein A1S9(gene name synonym)|uniprotkb:UBA1(gene name)|psi-mi:UBA1(display_short)|uniprotkb:A1S9T(gene name synonym)|uniprotkb:UBE1(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9970768|imex:IM-22822-41	author-confidence:Z-score = 3.63	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000036241(gene)|ensembl:ENSMUST00000040008(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0061631"(ubiquitin conjugating enzyme activity)|go:"GO:0070936"(protein K48-linked ubiquitination)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|go:"GO:0006513"(protein monoubiquitination)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|interpro:IPR023313|reactome:R-MMU-8866652|reactome:R-MMU-983168|refseq:NP_080551.1	refseq:NP_003325.2|refseq:NP_695012.1|refseq:XP_016885269.1|refseq:XP_016885270.1|dip:DIP-33686N|ensembl:ENSG00000130985(gene)|ensembl:ENST00000335972(transcript)|ensembl:ENST00000377351(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0004839"(ubiquitin activating enzyme activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0032446"(protein modification by small protein conjugation)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000011(Ubiquitin-activating enzyme, E1)|interpro:IPR000594(UBA/THIF-type NAD/FAD binding fold)|interpro:IPR018074|interpro:IPR018075|interpro:IPR018965|interpro:IPR019572|interpro:IPR032418|interpro:IPR032420|interpro:IPR033127|interpro:IPR035985|interpro:IPR038252|interpro:IPR042063|interpro:IPR042302|interpro:IPR042449|mint:P22314|rcsb pdb:4P22|rcsb pdb:6DC6|reactome:R-HSA-8866652|reactome:R-HSA-983168	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	comment:mint|function:Catalyzes the covalent attachment of ubiquitin to other proteins. May be involved in degradation of katenin	-	figure legend:Table S2|caution:"UBE2N has been marked as the enzyme in this assay, although it is the UBE2N-UBE2V1 complex that has ubiquitinase (E3) activity. Neither UBE2N nor UBE2V1 have E2 or E3 activity on their own."|resulting-ptm:Q6ZWZ2 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:fFTiply+7nUD6veFiQW5xcNmRrE10090	rogid:q+vEeA0XLST0Zz173bmEt0dNbDE9606	intact-crc:EDDB90584F023AEB|rigid:chd87EN8mssccq7gKy54JfEpTAs	false	-	his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q6ZWZ2	uniprotkb:P61088	intact:EBI-8587051|ensembl:ENSMUSP00000038813|uniprotkb:Q8BW18|uniprotkb:Q8VDE5|intact:MINT-4609410	intact:EBI-1052908|uniprotkb:Q16781|uniprotkb:Q53Y81|ensembl:ENSP00000316176	psi-mi:ub2r2_mouse(display_long)|uniprotkb:Ube2r2(gene name)|psi-mi:Ube2r2(display_short)|uniprotkb:Cdc34b(gene name synonym)|uniprotkb:Ubc3b(gene name synonym)|uniprotkb:Ubiquitin-protein ligase R2(gene name synonym)|uniprotkb:Ubiquitin carrier protein R2(gene name synonym)|uniprotkb:Ubiquitin-conjugating enzyme E2-CDC34B(gene name synonym)|uniprotkb:E2 ubiquitin-conjugating enzyme R2(gene name synonym)	psi-mi:ube2n_human(display_long)|uniprotkb:Ubiquitin-protein ligase N(gene name synonym)|uniprotkb:Ubiquitin carrier protein N(gene name synonym)|uniprotkb:Ubc13(gene name synonym)|uniprotkb:Bendless-like ubiquitin-conjugating enzyme(gene name synonym)|uniprotkb:UBE2N(gene name)|psi-mi:UBE2N(display_short)|uniprotkb:BLU(gene name synonym)|uniprotkb:UbcH13(gene name synonym)|uniprotkb:E2 ubiquitin-conjugating enzyme N(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9970768|imex:IM-22822-41	author-confidence:Z-score = 3.63	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000036241(gene)|ensembl:ENSMUST00000040008(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0061631"(ubiquitin conjugating enzyme activity)|go:"GO:0070936"(protein K48-linked ubiquitination)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|go:"GO:0006513"(protein monoubiquitination)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|interpro:IPR023313|reactome:R-MMU-8866652|reactome:R-MMU-983168|refseq:NP_080551.1	refseq:NP_003339.1|dip:DIP-29829N|ensembl:ENSG00000177889(gene)|ensembl:ENST00000318066(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000729"(DNA double-strand break processing)|go:"GO:0001650"(fibrillar center)|go:"GO:0003723"(RNA binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006282"(regulation of DNA repair)|go:"GO:0006301"(postreplication repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016574"(histone ubiquitination)|go:"GO:0031058"(positive regulation of histone modification)|go:"GO:0031372"(UBC13-MMS2 complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033182"(regulation of histone ubiquitination)|go:"GO:0035370"(UBC13-UEV1A complex)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0061631"(ubiquitin conjugating enzyme activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070534"(protein K63-linked ubiquitination)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|interpro:IPR023313|rcsb pdb:1J7D|rcsb pdb:2C2V|rcsb pdb:3HCT|rcsb pdb:3HCU|rcsb pdb:3VON|rcsb pdb:3W31|rcsb pdb:4DHI|rcsb pdb:4DHJ|rcsb pdb:4DHZ|rcsb pdb:4IP3|rcsb pdb:4NR3|rcsb pdb:4NRG|rcsb pdb:4NRI|rcsb pdb:4ONL|rcsb pdb:4ONM|rcsb pdb:4ONN|rcsb pdb:4ORH|rcsb pdb:4TKP|rcsb pdb:4WHV|rcsb pdb:5AIT|rcsb pdb:5AIU|rcsb pdb:5EYA|rcsb pdb:5H7S|rcsb pdb:5VNZ|rcsb pdb:5VO0|rcsb pdb:5YWR|rcsb pdb:6D6I|rcsb pdb:6JKY|rcsb pdb:6KFP|rcsb pdb:6KG6|rcsb pdb:6KL4|rcsb pdb:6LP2|rcsb pdb:6P5B|rcsb pdb:6S53|reactome:R-HSA-168927|reactome:R-HSA-202424|reactome:R-HSA-2871837|reactome:R-HSA-445989|reactome:R-HSA-450302|reactome:R-HSA-450321|reactome:R-HSA-5607764|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-5696395|reactome:R-HSA-69473|reactome:R-HSA-8866654|reactome:R-HSA-9020702|reactome:R-HSA-937039|reactome:R-HSA-937041|reactome:R-HSA-9646399|reactome:R-HSA-975110|reactome:R-HSA-975144|reactome:R-HSA-983168|rcsb pdb:6ULH|rcsb pdb:6UMP|rcsb pdb:6UMS|rcsb pdb:7BBD|rcsb pdb:7BBF|rcsb pdb:7BXG|reactome:R-HSA-1169408|reactome:R-HSA-168638	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	comment:mint|function:Catalyzes the covalent attachment of ubiquitin to other proteins. May be involved in degradation of katenin	-	figure legend:Table S2|caution:"UBE2N has been marked as the enzyme in this assay, although it is the UBE2N-UBE2V1 complex that has ubiquitinase (E3) activity. Neither UBE2N nor UBE2V1 have E2 or E3 activity on their own."|resulting-ptm:Q6ZWZ2 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:fFTiply+7nUD6veFiQW5xcNmRrE10090	rogid:dqdszHlq5FLPHC6UWX6uvkC6Yz89606	intact-crc:EDDB90584F023AEB|rigid:chd87EN8mssccq7gKy54JfEpTAs	false	-	his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q86UD5	uniprotkb:Q13404	intact:EBI-9916342|uniprotkb:Q6ZMD8|uniprotkb:Q96D95|uniprotkb:B5ME52|intact:EBI-28986221|ensembl:ENSP00000354574|ensembl:ENSP00000378265	intact:EBI-1050671|uniprotkb:Q13403|uniprotkb:Q13532|uniprotkb:Q96H34|uniprotkb:Q9GZT0|uniprotkb:Q9GZW1|uniprotkb:Q9H4J3|uniprotkb:Q9H4J4|uniprotkb:Q9UKL1|uniprotkb:Q9UM48|uniprotkb:Q9UM49|uniprotkb:Q9UM50|uniprotkb:Q5TGE3|uniprotkb:E1P629|uniprotkb:Q5TGE0|ensembl:ENSP00000360739	psi-mi:sl9b2_human(display_long)|uniprotkb:NHA2(gene name synonym)|uniprotkb:NHEDC2(gene name synonym)|uniprotkb:"Na(+)/H(+) exchanger-like domain-containing protein 2"(gene name synonym)|uniprotkb:Sodium/hydrogen exchanger-like domain-containing protein 2(gene name synonym)|uniprotkb:Solute carrier family 9 subfamily B member 2(gene name synonym)|uniprotkb:"Na(+)/H(+) exchanger NHA2"(gene name synonym)|uniprotkb:SLC9B2(gene name)|psi-mi:SLC9B2(display_short)	psi-mi:ub2v1_human(display_long)|uniprotkb:CROC-1(gene name synonym)|uniprotkb:TRAF6-regulated IKK activator 1 beta Uev1A(gene name synonym)|uniprotkb:P/OKcl.19(orf name)|uniprotkb:UBE2V1(gene name)|psi-mi:UBE2V1(display_short)|uniprotkb:CROC1(gene name synonym)|uniprotkb:UBE2V(gene name synonym)|uniprotkb:UEV1(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9970789|imex:IM-22822-42	author-confidence:Z-score = 11.86	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001287685.1|refseq:NP_849155.2|refseq:XP_006714148.1|ensembl:ENSP00000354574|ensembl:ENSP00000378265|ensembl:ENSG00000164038(gene)|ensembl:ENST00000362026(transcript)|ensembl:ENST00000394785(transcript)|go:"GO:0005451"("monovalent cation:proton antiporter activity")|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0006814"(sodium ion transport)|go:"GO:0010008"(endosome membrane)|go:"GO:0010348"("lithium:proton antiporter activity")|go:"GO:0015385"("sodium:proton antiporter activity")|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030317"(flagellated sperm motility)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0034220"(ion transmembrane transport)|go:"GO:0042802"(identical protein binding)|go:"GO:0061178"(regulation of insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0072583"(clathrin-dependent endocytosis)|go:"GO:0097228"(sperm principal piece)|go:"GO:2001206"(positive regulation of osteoclast development)|interpro:IPR006153(Sodium/hydrogen exchanger)|interpro:IPR037072|interpro:IPR038770|reactome:R-HSA-2672351	refseq:NP_001027459.1|refseq:NP_068823.2|refseq:NP_071887.1|refseq:NP_954595.1|refseq:NP_954673.1|refseq:NP_001244322.1|refseq:NP_001244323.1|refseq:NP_001244325.1|ensembl:ENSG00000244687(gene)|ensembl:ENST00000371674(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006282"(regulation of DNA repair)|go:"GO:0006301"(postreplication repair)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0030154"(cell differentiation)|go:"GO:0031371"(ubiquitin conjugating enzyme complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035370"(UBC13-UEV1A complex)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070534"(protein K63-linked ubiquitination)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|rcsb pdb:2A4D|rcsb pdb:2C2V|rcsb pdb:2HLW|rcsb pdb:6D6I|reactome:R-HSA-168638|reactome:R-HSA-168927|reactome:R-HSA-202424|reactome:R-HSA-2871837|reactome:R-HSA-445989|reactome:R-HSA-450302|reactome:R-HSA-450321|reactome:R-HSA-5607764|reactome:R-HSA-9020702|reactome:R-HSA-937039|reactome:R-HSA-937041|reactome:R-HSA-9646399|reactome:R-HSA-975110|reactome:R-HSA-975144|reactome:R-HSA-983168|dip:DIP-41911N	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S2|caution:"UBE2N has been marked as the enzyme in this assay, although it is the UBE2N-UBE2V1 complex that has ubiquitinase (E3) activity. Neither UBE2N nor UBE2V1 have E2 or E3 activity on their own."|resulting-ptm:Q86UD5 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:f7mRPxcQ6VLBnrZkLfn94/8dEP49606	rogid:x95N7Dj2KIqu5gySX59xLmfthUg9606	intact-crc:2EAB7319F355D2FD|rigid:RPFmESKKHvb49GR1/B4C6oDlzsQ	false	-	his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q86UD5	uniprotkb:P22314	intact:EBI-9916342|uniprotkb:Q6ZMD8|uniprotkb:Q96D95|uniprotkb:B5ME52|intact:EBI-28986221|ensembl:ENSP00000354574|ensembl:ENSP00000378265	intact:EBI-709688|uniprotkb:Q96E13|uniprotkb:Q5JRR8|ensembl:ENSP00000338413|ensembl:ENSP00000366568	psi-mi:sl9b2_human(display_long)|uniprotkb:NHA2(gene name synonym)|uniprotkb:NHEDC2(gene name synonym)|uniprotkb:"Na(+)/H(+) exchanger-like domain-containing protein 2"(gene name synonym)|uniprotkb:Sodium/hydrogen exchanger-like domain-containing protein 2(gene name synonym)|uniprotkb:Solute carrier family 9 subfamily B member 2(gene name synonym)|uniprotkb:"Na(+)/H(+) exchanger NHA2"(gene name synonym)|uniprotkb:SLC9B2(gene name)|psi-mi:SLC9B2(display_short)	psi-mi:uba1_human(display_long)|uniprotkb:Ubiquitin-activating enzyme E1(gene name synonym)|uniprotkb:Protein A1S9(gene name synonym)|uniprotkb:UBA1(gene name)|psi-mi:UBA1(display_short)|uniprotkb:A1S9T(gene name synonym)|uniprotkb:UBE1(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9970789|imex:IM-22822-42	author-confidence:Z-score = 11.86	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001287685.1|refseq:NP_849155.2|refseq:XP_006714148.1|ensembl:ENSP00000354574|ensembl:ENSP00000378265|ensembl:ENSG00000164038(gene)|ensembl:ENST00000362026(transcript)|ensembl:ENST00000394785(transcript)|go:"GO:0005451"("monovalent cation:proton antiporter activity")|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0006814"(sodium ion transport)|go:"GO:0010008"(endosome membrane)|go:"GO:0010348"("lithium:proton antiporter activity")|go:"GO:0015385"("sodium:proton antiporter activity")|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030317"(flagellated sperm motility)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0034220"(ion transmembrane transport)|go:"GO:0042802"(identical protein binding)|go:"GO:0061178"(regulation of insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0072583"(clathrin-dependent endocytosis)|go:"GO:0097228"(sperm principal piece)|go:"GO:2001206"(positive regulation of osteoclast development)|interpro:IPR006153(Sodium/hydrogen exchanger)|interpro:IPR037072|interpro:IPR038770|reactome:R-HSA-2672351	refseq:NP_003325.2|refseq:NP_695012.1|refseq:XP_016885269.1|refseq:XP_016885270.1|dip:DIP-33686N|ensembl:ENSG00000130985(gene)|ensembl:ENST00000335972(transcript)|ensembl:ENST00000377351(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0004839"(ubiquitin activating enzyme activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0032446"(protein modification by small protein conjugation)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000011(Ubiquitin-activating enzyme, E1)|interpro:IPR000594(UBA/THIF-type NAD/FAD binding fold)|interpro:IPR018074|interpro:IPR018075|interpro:IPR018965|interpro:IPR019572|interpro:IPR032418|interpro:IPR032420|interpro:IPR033127|interpro:IPR035985|interpro:IPR038252|interpro:IPR042063|interpro:IPR042302|interpro:IPR042449|mint:P22314|rcsb pdb:4P22|rcsb pdb:6DC6|reactome:R-HSA-8866652|reactome:R-HSA-983168	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S2|caution:"UBE2N has been marked as the enzyme in this assay, although it is the UBE2N-UBE2V1 complex that has ubiquitinase (E3) activity. Neither UBE2N nor UBE2V1 have E2 or E3 activity on their own."|resulting-ptm:Q86UD5 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:f7mRPxcQ6VLBnrZkLfn94/8dEP49606	rogid:q+vEeA0XLST0Zz173bmEt0dNbDE9606	intact-crc:2EAB7319F355D2FD|rigid:RPFmESKKHvb49GR1/B4C6oDlzsQ	false	-	his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q86UD5	uniprotkb:P61088	intact:EBI-9916342|uniprotkb:Q6ZMD8|uniprotkb:Q96D95|uniprotkb:B5ME52|intact:EBI-28986221|ensembl:ENSP00000354574|ensembl:ENSP00000378265	intact:EBI-1052908|uniprotkb:Q16781|uniprotkb:Q53Y81|ensembl:ENSP00000316176	psi-mi:sl9b2_human(display_long)|uniprotkb:NHA2(gene name synonym)|uniprotkb:NHEDC2(gene name synonym)|uniprotkb:"Na(+)/H(+) exchanger-like domain-containing protein 2"(gene name synonym)|uniprotkb:Sodium/hydrogen exchanger-like domain-containing protein 2(gene name synonym)|uniprotkb:Solute carrier family 9 subfamily B member 2(gene name synonym)|uniprotkb:"Na(+)/H(+) exchanger NHA2"(gene name synonym)|uniprotkb:SLC9B2(gene name)|psi-mi:SLC9B2(display_short)	psi-mi:ube2n_human(display_long)|uniprotkb:Ubiquitin-protein ligase N(gene name synonym)|uniprotkb:Ubiquitin carrier protein N(gene name synonym)|uniprotkb:Ubc13(gene name synonym)|uniprotkb:Bendless-like ubiquitin-conjugating enzyme(gene name synonym)|uniprotkb:UBE2N(gene name)|psi-mi:UBE2N(display_short)|uniprotkb:BLU(gene name synonym)|uniprotkb:UbcH13(gene name synonym)|uniprotkb:E2 ubiquitin-conjugating enzyme N(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9970789|imex:IM-22822-42	author-confidence:Z-score = 11.86	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001287685.1|refseq:NP_849155.2|refseq:XP_006714148.1|ensembl:ENSP00000354574|ensembl:ENSP00000378265|ensembl:ENSG00000164038(gene)|ensembl:ENST00000362026(transcript)|ensembl:ENST00000394785(transcript)|go:"GO:0005451"("monovalent cation:proton antiporter activity")|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0006814"(sodium ion transport)|go:"GO:0010008"(endosome membrane)|go:"GO:0010348"("lithium:proton antiporter activity")|go:"GO:0015385"("sodium:proton antiporter activity")|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030317"(flagellated sperm motility)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0034220"(ion transmembrane transport)|go:"GO:0042802"(identical protein binding)|go:"GO:0061178"(regulation of insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0072583"(clathrin-dependent endocytosis)|go:"GO:0097228"(sperm principal piece)|go:"GO:2001206"(positive regulation of osteoclast development)|interpro:IPR006153(Sodium/hydrogen exchanger)|interpro:IPR037072|interpro:IPR038770|reactome:R-HSA-2672351	refseq:NP_003339.1|dip:DIP-29829N|ensembl:ENSG00000177889(gene)|ensembl:ENST00000318066(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000729"(DNA double-strand break processing)|go:"GO:0001650"(fibrillar center)|go:"GO:0003723"(RNA binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006282"(regulation of DNA repair)|go:"GO:0006301"(postreplication repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016574"(histone ubiquitination)|go:"GO:0031058"(positive regulation of histone modification)|go:"GO:0031372"(UBC13-MMS2 complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033182"(regulation of histone ubiquitination)|go:"GO:0035370"(UBC13-UEV1A complex)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0061631"(ubiquitin conjugating enzyme activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070534"(protein K63-linked ubiquitination)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|interpro:IPR023313|rcsb pdb:1J7D|rcsb pdb:2C2V|rcsb pdb:3HCT|rcsb pdb:3HCU|rcsb pdb:3VON|rcsb pdb:3W31|rcsb pdb:4DHI|rcsb pdb:4DHJ|rcsb pdb:4DHZ|rcsb pdb:4IP3|rcsb pdb:4NR3|rcsb pdb:4NRG|rcsb pdb:4NRI|rcsb pdb:4ONL|rcsb pdb:4ONM|rcsb pdb:4ONN|rcsb pdb:4ORH|rcsb pdb:4TKP|rcsb pdb:4WHV|rcsb pdb:5AIT|rcsb pdb:5AIU|rcsb pdb:5EYA|rcsb pdb:5H7S|rcsb pdb:5VNZ|rcsb pdb:5VO0|rcsb pdb:5YWR|rcsb pdb:6D6I|rcsb pdb:6JKY|rcsb pdb:6KFP|rcsb pdb:6KG6|rcsb pdb:6KL4|rcsb pdb:6LP2|rcsb pdb:6P5B|rcsb pdb:6S53|reactome:R-HSA-168927|reactome:R-HSA-202424|reactome:R-HSA-2871837|reactome:R-HSA-445989|reactome:R-HSA-450302|reactome:R-HSA-450321|reactome:R-HSA-5607764|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-5696395|reactome:R-HSA-69473|reactome:R-HSA-8866654|reactome:R-HSA-9020702|reactome:R-HSA-937039|reactome:R-HSA-937041|reactome:R-HSA-9646399|reactome:R-HSA-975110|reactome:R-HSA-975144|reactome:R-HSA-983168|rcsb pdb:6ULH|rcsb pdb:6UMP|rcsb pdb:6UMS|rcsb pdb:7BBD|rcsb pdb:7BBF|rcsb pdb:7BXG|reactome:R-HSA-1169408|reactome:R-HSA-168638	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S2|caution:"UBE2N has been marked as the enzyme in this assay, although it is the UBE2N-UBE2V1 complex that has ubiquitinase (E3) activity. Neither UBE2N nor UBE2V1 have E2 or E3 activity on their own."|resulting-ptm:Q86UD5 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:f7mRPxcQ6VLBnrZkLfn94/8dEP49606	rogid:dqdszHlq5FLPHC6UWX6uvkC6Yz89606	intact-crc:2EAB7319F355D2FD|rigid:RPFmESKKHvb49GR1/B4C6oDlzsQ	false	-	his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q6ZTN6	uniprotkb:Q13404	intact:EBI-947028|uniprotkb:Q0VAK0|uniprotkb:Q6ZVD0|uniprotkb:Q86SU1|uniprotkb:D6RCN6|uniprotkb:Q0VGC3	intact:EBI-1050671|uniprotkb:Q13403|uniprotkb:Q13532|uniprotkb:Q96H34|uniprotkb:Q9GZT0|uniprotkb:Q9GZW1|uniprotkb:Q9H4J3|uniprotkb:Q9H4J4|uniprotkb:Q9UKL1|uniprotkb:Q9UM48|uniprotkb:Q9UM49|uniprotkb:Q9UM50|uniprotkb:Q5TGE3|uniprotkb:E1P629|uniprotkb:Q5TGE0|ensembl:ENSP00000360739	psi-mi:an13d_human(display_long)|uniprotkb:ANKRD13D(gene name)|psi-mi:ANKRD13D(display_short)	psi-mi:ub2v1_human(display_long)|uniprotkb:CROC-1(gene name synonym)|uniprotkb:TRAF6-regulated IKK activator 1 beta Uev1A(gene name synonym)|uniprotkb:P/OKcl.19(orf name)|uniprotkb:UBE2V1(gene name)|psi-mi:UBE2V1(display_short)|uniprotkb:CROC1(gene name synonym)|uniprotkb:UBE2V(gene name synonym)|uniprotkb:UEV1(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9970747|imex:IM-22822-40	author-confidence:Z-score = 4.12	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997237.2|interpro:IPR021832|interpro:IPR003903(Ubiquitin interacting motif)|refseq:NP_001334830.1|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0005737"(cytoplasm)|go:"GO:0005770"(late endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0140036"(ubiquitin-dependent protein binding)	refseq:NP_001027459.1|refseq:NP_068823.2|refseq:NP_071887.1|refseq:NP_954595.1|refseq:NP_954673.1|refseq:NP_001244322.1|refseq:NP_001244323.1|refseq:NP_001244325.1|ensembl:ENSG00000244687(gene)|ensembl:ENST00000371674(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006282"(regulation of DNA repair)|go:"GO:0006301"(postreplication repair)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0030154"(cell differentiation)|go:"GO:0031371"(ubiquitin conjugating enzyme complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035370"(UBC13-UEV1A complex)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070534"(protein K63-linked ubiquitination)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|rcsb pdb:2A4D|rcsb pdb:2C2V|rcsb pdb:2HLW|rcsb pdb:6D6I|reactome:R-HSA-168638|reactome:R-HSA-168927|reactome:R-HSA-202424|reactome:R-HSA-2871837|reactome:R-HSA-445989|reactome:R-HSA-450302|reactome:R-HSA-450321|reactome:R-HSA-5607764|reactome:R-HSA-9020702|reactome:R-HSA-937039|reactome:R-HSA-937041|reactome:R-HSA-9646399|reactome:R-HSA-975110|reactome:R-HSA-975144|reactome:R-HSA-983168|dip:DIP-41911N	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S2|caution:"UBE2N has been marked as the enzyme in this assay, although it is the UBE2N-UBE2V1 complex that has ubiquitinase (E3) activity. Neither UBE2N nor UBE2V1 have E2 or E3 activity on their own."|resulting-ptm:Q6ZTN6 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:zfydyyRFl3BWXOu/azPOVcLaJGk9606	rogid:x95N7Dj2KIqu5gySX59xLmfthUg9606	intact-crc:071EBFC531692BB5|rigid:i0q3PyzBrWr/GW4Wx/DQMftkA7I	false	-	his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q6ZTN6	uniprotkb:P22314	intact:EBI-947028|uniprotkb:Q0VAK0|uniprotkb:Q6ZVD0|uniprotkb:Q86SU1|uniprotkb:D6RCN6|uniprotkb:Q0VGC3	intact:EBI-709688|uniprotkb:Q96E13|uniprotkb:Q5JRR8|ensembl:ENSP00000338413|ensembl:ENSP00000366568	psi-mi:an13d_human(display_long)|uniprotkb:ANKRD13D(gene name)|psi-mi:ANKRD13D(display_short)	psi-mi:uba1_human(display_long)|uniprotkb:Ubiquitin-activating enzyme E1(gene name synonym)|uniprotkb:Protein A1S9(gene name synonym)|uniprotkb:UBA1(gene name)|psi-mi:UBA1(display_short)|uniprotkb:A1S9T(gene name synonym)|uniprotkb:UBE1(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9970747|imex:IM-22822-40	author-confidence:Z-score = 4.12	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997237.2|interpro:IPR021832|interpro:IPR003903(Ubiquitin interacting motif)|refseq:NP_001334830.1|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0005737"(cytoplasm)|go:"GO:0005770"(late endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0140036"(ubiquitin-dependent protein binding)	refseq:NP_003325.2|refseq:NP_695012.1|refseq:XP_016885269.1|refseq:XP_016885270.1|dip:DIP-33686N|ensembl:ENSG00000130985(gene)|ensembl:ENST00000335972(transcript)|ensembl:ENST00000377351(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0004839"(ubiquitin activating enzyme activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0032446"(protein modification by small protein conjugation)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000011(Ubiquitin-activating enzyme, E1)|interpro:IPR000594(UBA/THIF-type NAD/FAD binding fold)|interpro:IPR018074|interpro:IPR018075|interpro:IPR018965|interpro:IPR019572|interpro:IPR032418|interpro:IPR032420|interpro:IPR033127|interpro:IPR035985|interpro:IPR038252|interpro:IPR042063|interpro:IPR042302|interpro:IPR042449|mint:P22314|rcsb pdb:4P22|rcsb pdb:6DC6|reactome:R-HSA-8866652|reactome:R-HSA-983168	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S2|caution:"UBE2N has been marked as the enzyme in this assay, although it is the UBE2N-UBE2V1 complex that has ubiquitinase (E3) activity. Neither UBE2N nor UBE2V1 have E2 or E3 activity on their own."|resulting-ptm:Q6ZTN6 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:zfydyyRFl3BWXOu/azPOVcLaJGk9606	rogid:q+vEeA0XLST0Zz173bmEt0dNbDE9606	intact-crc:071EBFC531692BB5|rigid:i0q3PyzBrWr/GW4Wx/DQMftkA7I	false	-	his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q6ZTN6	uniprotkb:P61088	intact:EBI-947028|uniprotkb:Q0VAK0|uniprotkb:Q6ZVD0|uniprotkb:Q86SU1|uniprotkb:D6RCN6|uniprotkb:Q0VGC3	intact:EBI-1052908|uniprotkb:Q16781|uniprotkb:Q53Y81|ensembl:ENSP00000316176	psi-mi:an13d_human(display_long)|uniprotkb:ANKRD13D(gene name)|psi-mi:ANKRD13D(display_short)	psi-mi:ube2n_human(display_long)|uniprotkb:Ubiquitin-protein ligase N(gene name synonym)|uniprotkb:Ubiquitin carrier protein N(gene name synonym)|uniprotkb:Ubc13(gene name synonym)|uniprotkb:Bendless-like ubiquitin-conjugating enzyme(gene name synonym)|uniprotkb:UBE2N(gene name)|psi-mi:UBE2N(display_short)|uniprotkb:BLU(gene name synonym)|uniprotkb:UbcH13(gene name synonym)|uniprotkb:E2 ubiquitin-conjugating enzyme N(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9970747|imex:IM-22822-40	author-confidence:Z-score = 4.12	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_997237.2|interpro:IPR021832|interpro:IPR003903(Ubiquitin interacting motif)|refseq:NP_001334830.1|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0005737"(cytoplasm)|go:"GO:0005770"(late endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0140036"(ubiquitin-dependent protein binding)	refseq:NP_003339.1|dip:DIP-29829N|ensembl:ENSG00000177889(gene)|ensembl:ENST00000318066(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000729"(DNA double-strand break processing)|go:"GO:0001650"(fibrillar center)|go:"GO:0003723"(RNA binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006282"(regulation of DNA repair)|go:"GO:0006301"(postreplication repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016574"(histone ubiquitination)|go:"GO:0031058"(positive regulation of histone modification)|go:"GO:0031372"(UBC13-MMS2 complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033182"(regulation of histone ubiquitination)|go:"GO:0035370"(UBC13-UEV1A complex)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0061631"(ubiquitin conjugating enzyme activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070534"(protein K63-linked ubiquitination)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|interpro:IPR023313|rcsb pdb:1J7D|rcsb pdb:2C2V|rcsb pdb:3HCT|rcsb pdb:3HCU|rcsb pdb:3VON|rcsb pdb:3W31|rcsb pdb:4DHI|rcsb pdb:4DHJ|rcsb pdb:4DHZ|rcsb pdb:4IP3|rcsb pdb:4NR3|rcsb pdb:4NRG|rcsb pdb:4NRI|rcsb pdb:4ONL|rcsb pdb:4ONM|rcsb pdb:4ONN|rcsb pdb:4ORH|rcsb pdb:4TKP|rcsb pdb:4WHV|rcsb pdb:5AIT|rcsb pdb:5AIU|rcsb pdb:5EYA|rcsb pdb:5H7S|rcsb pdb:5VNZ|rcsb pdb:5VO0|rcsb pdb:5YWR|rcsb pdb:6D6I|rcsb pdb:6JKY|rcsb pdb:6KFP|rcsb pdb:6KG6|rcsb pdb:6KL4|rcsb pdb:6LP2|rcsb pdb:6P5B|rcsb pdb:6S53|reactome:R-HSA-168927|reactome:R-HSA-202424|reactome:R-HSA-2871837|reactome:R-HSA-445989|reactome:R-HSA-450302|reactome:R-HSA-450321|reactome:R-HSA-5607764|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-5696395|reactome:R-HSA-69473|reactome:R-HSA-8866654|reactome:R-HSA-9020702|reactome:R-HSA-937039|reactome:R-HSA-937041|reactome:R-HSA-9646399|reactome:R-HSA-975110|reactome:R-HSA-975144|reactome:R-HSA-983168|rcsb pdb:6ULH|rcsb pdb:6UMP|rcsb pdb:6UMS|rcsb pdb:7BBD|rcsb pdb:7BBF|rcsb pdb:7BXG|reactome:R-HSA-1169408|reactome:R-HSA-168638	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S2|caution:"UBE2N has been marked as the enzyme in this assay, although it is the UBE2N-UBE2V1 complex that has ubiquitinase (E3) activity. Neither UBE2N nor UBE2V1 have E2 or E3 activity on their own."|resulting-ptm:Q6ZTN6 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:zfydyyRFl3BWXOu/azPOVcLaJGk9606	rogid:dqdszHlq5FLPHC6UWX6uvkC6Yz89606	intact-crc:071EBFC531692BB5|rigid:i0q3PyzBrWr/GW4Wx/DQMftkA7I	false	-	his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q8IZ07	uniprotkb:Q13404	intact:EBI-2876152|ensembl:ENSP00000261739|uniprotkb:O60736	intact:EBI-1050671|uniprotkb:Q13403|uniprotkb:Q13532|uniprotkb:Q96H34|uniprotkb:Q9GZT0|uniprotkb:Q9GZW1|uniprotkb:Q9H4J3|uniprotkb:Q9H4J4|uniprotkb:Q9UKL1|uniprotkb:Q9UM48|uniprotkb:Q9UM49|uniprotkb:Q9UM50|uniprotkb:Q5TGE3|uniprotkb:E1P629|uniprotkb:Q5TGE0|ensembl:ENSP00000360739	psi-mi:an13a_human(display_long)|uniprotkb:ANKRD13A(gene name)|psi-mi:ANKRD13A(display_short)|uniprotkb:ANKRD13(gene name synonym)|uniprotkb:Protein KE03(gene name synonym)	psi-mi:ub2v1_human(display_long)|uniprotkb:CROC-1(gene name synonym)|uniprotkb:TRAF6-regulated IKK activator 1 beta Uev1A(gene name synonym)|uniprotkb:P/OKcl.19(orf name)|uniprotkb:UBE2V1(gene name)|psi-mi:UBE2V1(display_short)|uniprotkb:CROC1(gene name synonym)|uniprotkb:UBE2V(gene name synonym)|uniprotkb:UEV1(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9970831|imex:IM-22822-44	author-confidence:Z-score = 4.30	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000076513(gene)|ensembl:ENST00000261739(transcript)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0005737"(cytoplasm)|go:"GO:0005770"(late endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0140036"(ubiquitin-dependent protein binding)|go:"GO:1905667"(negative regulation of protein localization to endosome)|interpro:IPR002110(Ankyrin)|interpro:IPR003903(Ubiquitin interacting motif)|interpro:IPR021832|interpro:IPR036770|refseq:NP_149112.1	refseq:NP_001027459.1|refseq:NP_068823.2|refseq:NP_071887.1|refseq:NP_954595.1|refseq:NP_954673.1|refseq:NP_001244322.1|refseq:NP_001244323.1|refseq:NP_001244325.1|ensembl:ENSG00000244687(gene)|ensembl:ENST00000371674(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006282"(regulation of DNA repair)|go:"GO:0006301"(postreplication repair)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0030154"(cell differentiation)|go:"GO:0031371"(ubiquitin conjugating enzyme complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035370"(UBC13-UEV1A complex)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070534"(protein K63-linked ubiquitination)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|rcsb pdb:2A4D|rcsb pdb:2C2V|rcsb pdb:2HLW|rcsb pdb:6D6I|reactome:R-HSA-168638|reactome:R-HSA-168927|reactome:R-HSA-202424|reactome:R-HSA-2871837|reactome:R-HSA-445989|reactome:R-HSA-450302|reactome:R-HSA-450321|reactome:R-HSA-5607764|reactome:R-HSA-9020702|reactome:R-HSA-937039|reactome:R-HSA-937041|reactome:R-HSA-9646399|reactome:R-HSA-975110|reactome:R-HSA-975144|reactome:R-HSA-983168|dip:DIP-41911N	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S2|caution:"UBE2N has been marked as the enzyme in this assay, although it is the UBE2N-UBE2V1 complex that has ubiquitinase (E3) activity. Neither UBE2N nor UBE2V1 have E2 or E3 activity on their own."|resulting-ptm:Q8IZ07 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:RI4K5f4Ks8YSRYUO/FEQNCRkI389606	rogid:x95N7Dj2KIqu5gySX59xLmfthUg9606	intact-crc:9B177B74DAC661AF|rigid:ot1X/VxqjGmO11k57HleogAm880	false	-	his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q8IZ07	uniprotkb:P22314	intact:EBI-2876152|ensembl:ENSP00000261739|uniprotkb:O60736	intact:EBI-709688|uniprotkb:Q96E13|uniprotkb:Q5JRR8|ensembl:ENSP00000338413|ensembl:ENSP00000366568	psi-mi:an13a_human(display_long)|uniprotkb:ANKRD13A(gene name)|psi-mi:ANKRD13A(display_short)|uniprotkb:ANKRD13(gene name synonym)|uniprotkb:Protein KE03(gene name synonym)	psi-mi:uba1_human(display_long)|uniprotkb:Ubiquitin-activating enzyme E1(gene name synonym)|uniprotkb:Protein A1S9(gene name synonym)|uniprotkb:UBA1(gene name)|psi-mi:UBA1(display_short)|uniprotkb:A1S9T(gene name synonym)|uniprotkb:UBE1(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9970831|imex:IM-22822-44	author-confidence:Z-score = 4.30	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000076513(gene)|ensembl:ENST00000261739(transcript)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0005737"(cytoplasm)|go:"GO:0005770"(late endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0140036"(ubiquitin-dependent protein binding)|go:"GO:1905667"(negative regulation of protein localization to endosome)|interpro:IPR002110(Ankyrin)|interpro:IPR003903(Ubiquitin interacting motif)|interpro:IPR021832|interpro:IPR036770|refseq:NP_149112.1	refseq:NP_003325.2|refseq:NP_695012.1|refseq:XP_016885269.1|refseq:XP_016885270.1|dip:DIP-33686N|ensembl:ENSG00000130985(gene)|ensembl:ENST00000335972(transcript)|ensembl:ENST00000377351(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0004839"(ubiquitin activating enzyme activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0032446"(protein modification by small protein conjugation)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000011(Ubiquitin-activating enzyme, E1)|interpro:IPR000594(UBA/THIF-type NAD/FAD binding fold)|interpro:IPR018074|interpro:IPR018075|interpro:IPR018965|interpro:IPR019572|interpro:IPR032418|interpro:IPR032420|interpro:IPR033127|interpro:IPR035985|interpro:IPR038252|interpro:IPR042063|interpro:IPR042302|interpro:IPR042449|mint:P22314|rcsb pdb:4P22|rcsb pdb:6DC6|reactome:R-HSA-8866652|reactome:R-HSA-983168	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S2|caution:"UBE2N has been marked as the enzyme in this assay, although it is the UBE2N-UBE2V1 complex that has ubiquitinase (E3) activity. Neither UBE2N nor UBE2V1 have E2 or E3 activity on their own."|resulting-ptm:Q8IZ07 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:RI4K5f4Ks8YSRYUO/FEQNCRkI389606	rogid:q+vEeA0XLST0Zz173bmEt0dNbDE9606	intact-crc:9B177B74DAC661AF|rigid:ot1X/VxqjGmO11k57HleogAm880	false	-	his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q8IZ07	uniprotkb:P61088	intact:EBI-2876152|ensembl:ENSP00000261739|uniprotkb:O60736	intact:EBI-1052908|uniprotkb:Q16781|uniprotkb:Q53Y81|ensembl:ENSP00000316176	psi-mi:an13a_human(display_long)|uniprotkb:ANKRD13A(gene name)|psi-mi:ANKRD13A(display_short)|uniprotkb:ANKRD13(gene name synonym)|uniprotkb:Protein KE03(gene name synonym)	psi-mi:ube2n_human(display_long)|uniprotkb:Ubiquitin-protein ligase N(gene name synonym)|uniprotkb:Ubiquitin carrier protein N(gene name synonym)|uniprotkb:Ubc13(gene name synonym)|uniprotkb:Bendless-like ubiquitin-conjugating enzyme(gene name synonym)|uniprotkb:UBE2N(gene name)|psi-mi:UBE2N(display_short)|uniprotkb:BLU(gene name synonym)|uniprotkb:UbcH13(gene name synonym)|uniprotkb:E2 ubiquitin-conjugating enzyme N(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9970831|imex:IM-22822-44	author-confidence:Z-score = 4.30	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000076513(gene)|ensembl:ENST00000261739(transcript)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0005737"(cytoplasm)|go:"GO:0005770"(late endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0140036"(ubiquitin-dependent protein binding)|go:"GO:1905667"(negative regulation of protein localization to endosome)|interpro:IPR002110(Ankyrin)|interpro:IPR003903(Ubiquitin interacting motif)|interpro:IPR021832|interpro:IPR036770|refseq:NP_149112.1	refseq:NP_003339.1|dip:DIP-29829N|ensembl:ENSG00000177889(gene)|ensembl:ENST00000318066(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000729"(DNA double-strand break processing)|go:"GO:0001650"(fibrillar center)|go:"GO:0003723"(RNA binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006282"(regulation of DNA repair)|go:"GO:0006301"(postreplication repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016574"(histone ubiquitination)|go:"GO:0031058"(positive regulation of histone modification)|go:"GO:0031372"(UBC13-MMS2 complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033182"(regulation of histone ubiquitination)|go:"GO:0035370"(UBC13-UEV1A complex)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0061631"(ubiquitin conjugating enzyme activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070534"(protein K63-linked ubiquitination)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|interpro:IPR023313|rcsb pdb:1J7D|rcsb pdb:2C2V|rcsb pdb:3HCT|rcsb pdb:3HCU|rcsb pdb:3VON|rcsb pdb:3W31|rcsb pdb:4DHI|rcsb pdb:4DHJ|rcsb pdb:4DHZ|rcsb pdb:4IP3|rcsb pdb:4NR3|rcsb pdb:4NRG|rcsb pdb:4NRI|rcsb pdb:4ONL|rcsb pdb:4ONM|rcsb pdb:4ONN|rcsb pdb:4ORH|rcsb pdb:4TKP|rcsb pdb:4WHV|rcsb pdb:5AIT|rcsb pdb:5AIU|rcsb pdb:5EYA|rcsb pdb:5H7S|rcsb pdb:5VNZ|rcsb pdb:5VO0|rcsb pdb:5YWR|rcsb pdb:6D6I|rcsb pdb:6JKY|rcsb pdb:6KFP|rcsb pdb:6KG6|rcsb pdb:6KL4|rcsb pdb:6LP2|rcsb pdb:6P5B|rcsb pdb:6S53|reactome:R-HSA-168927|reactome:R-HSA-202424|reactome:R-HSA-2871837|reactome:R-HSA-445989|reactome:R-HSA-450302|reactome:R-HSA-450321|reactome:R-HSA-5607764|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-5696395|reactome:R-HSA-69473|reactome:R-HSA-8866654|reactome:R-HSA-9020702|reactome:R-HSA-937039|reactome:R-HSA-937041|reactome:R-HSA-9646399|reactome:R-HSA-975110|reactome:R-HSA-975144|reactome:R-HSA-983168|rcsb pdb:6ULH|rcsb pdb:6UMP|rcsb pdb:6UMS|rcsb pdb:7BBD|rcsb pdb:7BBF|rcsb pdb:7BXG|reactome:R-HSA-1169408|reactome:R-HSA-168638	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S2|caution:"UBE2N has been marked as the enzyme in this assay, although it is the UBE2N-UBE2V1 complex that has ubiquitinase (E3) activity. Neither UBE2N nor UBE2V1 have E2 or E3 activity on their own."|resulting-ptm:Q8IZ07 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:RI4K5f4Ks8YSRYUO/FEQNCRkI389606	rogid:dqdszHlq5FLPHC6UWX6uvkC6Yz89606	intact-crc:9B177B74DAC661AF|rigid:ot1X/VxqjGmO11k57HleogAm880	false	-	his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q8IUD6	uniprotkb:Q13404	intact:EBI-9916363|uniprotkb:F5GX60|uniprotkb:B2R7G9|uniprotkb:Q9BSE9|uniprotkb:B6ZLM5|uniprotkb:A0AVM5|ensembl:ENSP00000328340	intact:EBI-1050671|uniprotkb:Q13403|uniprotkb:Q13532|uniprotkb:Q96H34|uniprotkb:Q9GZT0|uniprotkb:Q9GZW1|uniprotkb:Q9H4J3|uniprotkb:Q9H4J4|uniprotkb:Q9UKL1|uniprotkb:Q9UM48|uniprotkb:Q9UM49|uniprotkb:Q9UM50|uniprotkb:Q5TGE3|uniprotkb:E1P629|uniprotkb:Q5TGE0|ensembl:ENSP00000360739	psi-mi:rn135_human(display_long)|uniprotkb:RIG-I E3 ubiquitin ligase(gene name synonym)|uniprotkb:RING finger protein 135(gene name synonym)|uniprotkb:L13(orf name)|uniprotkb:RING finger protein leading to RIG-I activation(gene name synonym)|uniprotkb:RNF135(gene name)|psi-mi:RNF135(display_short)|uniprotkb:RING-type E3 ubiquitin transferase RNF135(gene name synonym)	psi-mi:ub2v1_human(display_long)|uniprotkb:CROC-1(gene name synonym)|uniprotkb:TRAF6-regulated IKK activator 1 beta Uev1A(gene name synonym)|uniprotkb:P/OKcl.19(orf name)|uniprotkb:UBE2V1(gene name)|psi-mi:UBE2V1(display_short)|uniprotkb:CROC1(gene name synonym)|uniprotkb:UBE2V(gene name synonym)|uniprotkb:UEV1(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9970810|imex:IM-22822-43	author-confidence:Z-score = 11.67	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001171921.1|refseq:NP_115698.3|refseq:NP_922921.1|ensembl:ENST00000324689|ensembl:ENSP00000323693|ensembl:ENSP00000328340|ensembl:ENST00000535306|ensembl:ENSP00000440470|ensembl:ENSG00000181481(gene)|ensembl:ENST00000328381(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010994"(free ubiquitin chain polymerization)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0039529"(RIG-I signaling pathway)|go:"GO:0039552"(RIG-I binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043021"(ribonucleoprotein complex binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045088"(regulation of innate immune response)|go:"GO:0046872"(metal ion binding)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0140374"(antiviral innate immune response)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR001870("B302 (SPRY)-like")|interpro:IPR003877(SPla/RYanodine receptor SPRY)|interpro:IPR003879(Butyrophylin-like)|interpro:IPR006574(SPRY-associated)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR017907|interpro:IPR042723|interpro:IPR043136|rcsb pdb:7JL1|rcsb pdb:7JL3|reactome:R-HSA-168928|reactome:R-HSA-5689896|reactome:R-HSA-918233|reactome:R-HSA-933541|reactome:R-HSA-933542|reactome:R-HSA-933543|reactome:R-HSA-936440	refseq:NP_001027459.1|refseq:NP_068823.2|refseq:NP_071887.1|refseq:NP_954595.1|refseq:NP_954673.1|refseq:NP_001244322.1|refseq:NP_001244323.1|refseq:NP_001244325.1|ensembl:ENSG00000244687(gene)|ensembl:ENST00000371674(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006282"(regulation of DNA repair)|go:"GO:0006301"(postreplication repair)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0030154"(cell differentiation)|go:"GO:0031371"(ubiquitin conjugating enzyme complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035370"(UBC13-UEV1A complex)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070534"(protein K63-linked ubiquitination)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|rcsb pdb:2A4D|rcsb pdb:2C2V|rcsb pdb:2HLW|rcsb pdb:6D6I|reactome:R-HSA-168638|reactome:R-HSA-168927|reactome:R-HSA-202424|reactome:R-HSA-2871837|reactome:R-HSA-445989|reactome:R-HSA-450302|reactome:R-HSA-450321|reactome:R-HSA-5607764|reactome:R-HSA-9020702|reactome:R-HSA-937039|reactome:R-HSA-937041|reactome:R-HSA-9646399|reactome:R-HSA-975110|reactome:R-HSA-975144|reactome:R-HSA-983168|dip:DIP-41911N	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S2|caution:"UBE2N has been marked as the enzyme in this assay, although it is the UBE2N-UBE2V1 complex that has ubiquitinase (E3) activity. Neither UBE2N nor UBE2V1 have E2 or E3 activity on their own."|resulting-ptm:Q8IUD6 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:mcJIGnAyWJN1YnMyXqXotOwjN6M9606	rogid:x95N7Dj2KIqu5gySX59xLmfthUg9606	intact-crc:164075ACEA9880F7|rigid:ArS9W85SaYVRjSWnXwk71GuOF50	false	-	his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q8IUD6	uniprotkb:P22314	intact:EBI-9916363|uniprotkb:F5GX60|uniprotkb:B2R7G9|uniprotkb:Q9BSE9|uniprotkb:B6ZLM5|uniprotkb:A0AVM5|ensembl:ENSP00000328340	intact:EBI-709688|uniprotkb:Q96E13|uniprotkb:Q5JRR8|ensembl:ENSP00000338413|ensembl:ENSP00000366568	psi-mi:rn135_human(display_long)|uniprotkb:RIG-I E3 ubiquitin ligase(gene name synonym)|uniprotkb:RING finger protein 135(gene name synonym)|uniprotkb:L13(orf name)|uniprotkb:RING finger protein leading to RIG-I activation(gene name synonym)|uniprotkb:RNF135(gene name)|psi-mi:RNF135(display_short)|uniprotkb:RING-type E3 ubiquitin transferase RNF135(gene name synonym)	psi-mi:uba1_human(display_long)|uniprotkb:Ubiquitin-activating enzyme E1(gene name synonym)|uniprotkb:Protein A1S9(gene name synonym)|uniprotkb:UBA1(gene name)|psi-mi:UBA1(display_short)|uniprotkb:A1S9T(gene name synonym)|uniprotkb:UBE1(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9970810|imex:IM-22822-43	author-confidence:Z-score = 11.67	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001171921.1|refseq:NP_115698.3|refseq:NP_922921.1|ensembl:ENST00000324689|ensembl:ENSP00000323693|ensembl:ENSP00000328340|ensembl:ENST00000535306|ensembl:ENSP00000440470|ensembl:ENSG00000181481(gene)|ensembl:ENST00000328381(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010994"(free ubiquitin chain polymerization)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0039529"(RIG-I signaling pathway)|go:"GO:0039552"(RIG-I binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043021"(ribonucleoprotein complex binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045088"(regulation of innate immune response)|go:"GO:0046872"(metal ion binding)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0140374"(antiviral innate immune response)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR001870("B302 (SPRY)-like")|interpro:IPR003877(SPla/RYanodine receptor SPRY)|interpro:IPR003879(Butyrophylin-like)|interpro:IPR006574(SPRY-associated)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR017907|interpro:IPR042723|interpro:IPR043136|rcsb pdb:7JL1|rcsb pdb:7JL3|reactome:R-HSA-168928|reactome:R-HSA-5689896|reactome:R-HSA-918233|reactome:R-HSA-933541|reactome:R-HSA-933542|reactome:R-HSA-933543|reactome:R-HSA-936440	refseq:NP_003325.2|refseq:NP_695012.1|refseq:XP_016885269.1|refseq:XP_016885270.1|dip:DIP-33686N|ensembl:ENSG00000130985(gene)|ensembl:ENST00000335972(transcript)|ensembl:ENST00000377351(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0004839"(ubiquitin activating enzyme activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0032446"(protein modification by small protein conjugation)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000011(Ubiquitin-activating enzyme, E1)|interpro:IPR000594(UBA/THIF-type NAD/FAD binding fold)|interpro:IPR018074|interpro:IPR018075|interpro:IPR018965|interpro:IPR019572|interpro:IPR032418|interpro:IPR032420|interpro:IPR033127|interpro:IPR035985|interpro:IPR038252|interpro:IPR042063|interpro:IPR042302|interpro:IPR042449|mint:P22314|rcsb pdb:4P22|rcsb pdb:6DC6|reactome:R-HSA-8866652|reactome:R-HSA-983168	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S2|caution:"UBE2N has been marked as the enzyme in this assay, although it is the UBE2N-UBE2V1 complex that has ubiquitinase (E3) activity. Neither UBE2N nor UBE2V1 have E2 or E3 activity on their own."|resulting-ptm:Q8IUD6 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:mcJIGnAyWJN1YnMyXqXotOwjN6M9606	rogid:q+vEeA0XLST0Zz173bmEt0dNbDE9606	intact-crc:164075ACEA9880F7|rigid:ArS9W85SaYVRjSWnXwk71GuOF50	false	-	his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q8IUD6	uniprotkb:P61088	intact:EBI-9916363|uniprotkb:F5GX60|uniprotkb:B2R7G9|uniprotkb:Q9BSE9|uniprotkb:B6ZLM5|uniprotkb:A0AVM5|ensembl:ENSP00000328340	intact:EBI-1052908|uniprotkb:Q16781|uniprotkb:Q53Y81|ensembl:ENSP00000316176	psi-mi:rn135_human(display_long)|uniprotkb:RIG-I E3 ubiquitin ligase(gene name synonym)|uniprotkb:RING finger protein 135(gene name synonym)|uniprotkb:L13(orf name)|uniprotkb:RING finger protein leading to RIG-I activation(gene name synonym)|uniprotkb:RNF135(gene name)|psi-mi:RNF135(display_short)|uniprotkb:RING-type E3 ubiquitin transferase RNF135(gene name synonym)	psi-mi:ube2n_human(display_long)|uniprotkb:Ubiquitin-protein ligase N(gene name synonym)|uniprotkb:Ubiquitin carrier protein N(gene name synonym)|uniprotkb:Ubc13(gene name synonym)|uniprotkb:Bendless-like ubiquitin-conjugating enzyme(gene name synonym)|uniprotkb:UBE2N(gene name)|psi-mi:UBE2N(display_short)|uniprotkb:BLU(gene name synonym)|uniprotkb:UbcH13(gene name synonym)|uniprotkb:E2 ubiquitin-conjugating enzyme N(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9970810|imex:IM-22822-43	author-confidence:Z-score = 11.67	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001171921.1|refseq:NP_115698.3|refseq:NP_922921.1|ensembl:ENST00000324689|ensembl:ENSP00000323693|ensembl:ENSP00000328340|ensembl:ENST00000535306|ensembl:ENSP00000440470|ensembl:ENSG00000181481(gene)|ensembl:ENST00000328381(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010994"(free ubiquitin chain polymerization)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0039529"(RIG-I signaling pathway)|go:"GO:0039552"(RIG-I binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043021"(ribonucleoprotein complex binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045088"(regulation of innate immune response)|go:"GO:0046872"(metal ion binding)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0140374"(antiviral innate immune response)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR001870("B302 (SPRY)-like")|interpro:IPR003877(SPla/RYanodine receptor SPRY)|interpro:IPR003879(Butyrophylin-like)|interpro:IPR006574(SPRY-associated)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR017907|interpro:IPR042723|interpro:IPR043136|rcsb pdb:7JL1|rcsb pdb:7JL3|reactome:R-HSA-168928|reactome:R-HSA-5689896|reactome:R-HSA-918233|reactome:R-HSA-933541|reactome:R-HSA-933542|reactome:R-HSA-933543|reactome:R-HSA-936440	refseq:NP_003339.1|dip:DIP-29829N|ensembl:ENSG00000177889(gene)|ensembl:ENST00000318066(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000729"(DNA double-strand break processing)|go:"GO:0001650"(fibrillar center)|go:"GO:0003723"(RNA binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006282"(regulation of DNA repair)|go:"GO:0006301"(postreplication repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016574"(histone ubiquitination)|go:"GO:0031058"(positive regulation of histone modification)|go:"GO:0031372"(UBC13-MMS2 complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033182"(regulation of histone ubiquitination)|go:"GO:0035370"(UBC13-UEV1A complex)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0061631"(ubiquitin conjugating enzyme activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070534"(protein K63-linked ubiquitination)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|interpro:IPR023313|rcsb pdb:1J7D|rcsb pdb:2C2V|rcsb pdb:3HCT|rcsb pdb:3HCU|rcsb pdb:3VON|rcsb pdb:3W31|rcsb pdb:4DHI|rcsb pdb:4DHJ|rcsb pdb:4DHZ|rcsb pdb:4IP3|rcsb pdb:4NR3|rcsb pdb:4NRG|rcsb pdb:4NRI|rcsb pdb:4ONL|rcsb pdb:4ONM|rcsb pdb:4ONN|rcsb pdb:4ORH|rcsb pdb:4TKP|rcsb pdb:4WHV|rcsb pdb:5AIT|rcsb pdb:5AIU|rcsb pdb:5EYA|rcsb pdb:5H7S|rcsb pdb:5VNZ|rcsb pdb:5VO0|rcsb pdb:5YWR|rcsb pdb:6D6I|rcsb pdb:6JKY|rcsb pdb:6KFP|rcsb pdb:6KG6|rcsb pdb:6KL4|rcsb pdb:6LP2|rcsb pdb:6P5B|rcsb pdb:6S53|reactome:R-HSA-168927|reactome:R-HSA-202424|reactome:R-HSA-2871837|reactome:R-HSA-445989|reactome:R-HSA-450302|reactome:R-HSA-450321|reactome:R-HSA-5607764|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-5696395|reactome:R-HSA-69473|reactome:R-HSA-8866654|reactome:R-HSA-9020702|reactome:R-HSA-937039|reactome:R-HSA-937041|reactome:R-HSA-9646399|reactome:R-HSA-975110|reactome:R-HSA-975144|reactome:R-HSA-983168|rcsb pdb:6ULH|rcsb pdb:6UMP|rcsb pdb:6UMS|rcsb pdb:7BBD|rcsb pdb:7BBF|rcsb pdb:7BXG|reactome:R-HSA-1169408|reactome:R-HSA-168638	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S2|caution:"UBE2N has been marked as the enzyme in this assay, although it is the UBE2N-UBE2V1 complex that has ubiquitinase (E3) activity. Neither UBE2N nor UBE2V1 have E2 or E3 activity on their own."|resulting-ptm:Q8IUD6 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:mcJIGnAyWJN1YnMyXqXotOwjN6M9606	rogid:dqdszHlq5FLPHC6UWX6uvkC6Yz89606	intact-crc:164075ACEA9880F7|rigid:ArS9W85SaYVRjSWnXwk71GuOF50	false	-	his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q8NFT6	uniprotkb:Q13404	intact:EBI-749662|uniprotkb:Q8TEX0|uniprotkb:Q9H912|uniprotkb:Q96B19|uniprotkb:D3DX56|ensembl:ENSP00000323663	intact:EBI-1050671|uniprotkb:Q13403|uniprotkb:Q13532|uniprotkb:Q96H34|uniprotkb:Q9GZT0|uniprotkb:Q9GZW1|uniprotkb:Q9H4J3|uniprotkb:Q9H4J4|uniprotkb:Q9UKL1|uniprotkb:Q9UM48|uniprotkb:Q9UM49|uniprotkb:Q9UM50|uniprotkb:Q5TGE3|uniprotkb:E1P629|uniprotkb:Q5TGE0|ensembl:ENSP00000360739	psi-mi:dbf4b_human(display_long)|uniprotkb:ASKL1(gene name synonym)|uniprotkb:DRF1(gene name synonym)|uniprotkb:Activator of S phase kinase-like protein 1(gene name synonym)|uniprotkb:Dbf4-related factor 1(gene name synonym)|uniprotkb:Chiffon homolog B(gene name synonym)|uniprotkb:DBF4B(gene name)|psi-mi:DBF4B(display_short)	psi-mi:ub2v1_human(display_long)|uniprotkb:CROC-1(gene name synonym)|uniprotkb:TRAF6-regulated IKK activator 1 beta Uev1A(gene name synonym)|uniprotkb:P/OKcl.19(orf name)|uniprotkb:UBE2V1(gene name)|psi-mi:UBE2V1(display_short)|uniprotkb:CROC1(gene name synonym)|uniprotkb:UBE2V(gene name synonym)|uniprotkb:UEV1(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9970873|imex:IM-22822-46	author-confidence:Z-score = 6.78	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_079380.2|refseq:NP_663696.1|refseq:XP_011523583.1|refseq:XP_006722165.1|ensembl:ENSG00000161692(gene)|ensembl:ENST00000315005(transcript)|go:"GO:0003676"(nucleic acid binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0007049"(cell cycle)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010971"(positive regulation of G2/M transition of mitotic cell cycle)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030295"(protein kinase activator activity)|go:"GO:0031431"(Dbf4-dependent protein kinase complex)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:1901987"(regulation of cell cycle phase transition)|interpro:IPR006572(Zinc finger, DBF-type)|interpro:IPR038545|mint:Q8NFT6|go:"GO:0010571"(positive regulation of nuclear cell cycle DNA replication)	refseq:NP_001027459.1|refseq:NP_068823.2|refseq:NP_071887.1|refseq:NP_954595.1|refseq:NP_954673.1|refseq:NP_001244322.1|refseq:NP_001244323.1|refseq:NP_001244325.1|ensembl:ENSG00000244687(gene)|ensembl:ENST00000371674(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006282"(regulation of DNA repair)|go:"GO:0006301"(postreplication repair)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0030154"(cell differentiation)|go:"GO:0031371"(ubiquitin conjugating enzyme complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035370"(UBC13-UEV1A complex)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070534"(protein K63-linked ubiquitination)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|rcsb pdb:2A4D|rcsb pdb:2C2V|rcsb pdb:2HLW|rcsb pdb:6D6I|reactome:R-HSA-168638|reactome:R-HSA-168927|reactome:R-HSA-202424|reactome:R-HSA-2871837|reactome:R-HSA-445989|reactome:R-HSA-450302|reactome:R-HSA-450321|reactome:R-HSA-5607764|reactome:R-HSA-9020702|reactome:R-HSA-937039|reactome:R-HSA-937041|reactome:R-HSA-9646399|reactome:R-HSA-975110|reactome:R-HSA-975144|reactome:R-HSA-983168|dip:DIP-41911N	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S2|caution:"UBE2N has been marked as the enzyme in this assay, although it is the UBE2N-UBE2V1 complex that has ubiquitinase (E3) activity. Neither UBE2N nor UBE2V1 have E2 or E3 activity on their own."|resulting-ptm:Q8NFT6 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:BdvmDAqRsWqg1qbvLLc/uVtXEiI9606	rogid:x95N7Dj2KIqu5gySX59xLmfthUg9606	intact-crc:BE59E3CDA1038102|rigid:wgrBIg/kfTyVpGndBifPC5m2zRs	false	-	his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q8NFT6	uniprotkb:P22314	intact:EBI-749662|uniprotkb:Q8TEX0|uniprotkb:Q9H912|uniprotkb:Q96B19|uniprotkb:D3DX56|ensembl:ENSP00000323663	intact:EBI-709688|uniprotkb:Q96E13|uniprotkb:Q5JRR8|ensembl:ENSP00000338413|ensembl:ENSP00000366568	psi-mi:dbf4b_human(display_long)|uniprotkb:ASKL1(gene name synonym)|uniprotkb:DRF1(gene name synonym)|uniprotkb:Activator of S phase kinase-like protein 1(gene name synonym)|uniprotkb:Dbf4-related factor 1(gene name synonym)|uniprotkb:Chiffon homolog B(gene name synonym)|uniprotkb:DBF4B(gene name)|psi-mi:DBF4B(display_short)	psi-mi:uba1_human(display_long)|uniprotkb:Ubiquitin-activating enzyme E1(gene name synonym)|uniprotkb:Protein A1S9(gene name synonym)|uniprotkb:UBA1(gene name)|psi-mi:UBA1(display_short)|uniprotkb:A1S9T(gene name synonym)|uniprotkb:UBE1(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9970873|imex:IM-22822-46	author-confidence:Z-score = 6.78	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_079380.2|refseq:NP_663696.1|refseq:XP_011523583.1|refseq:XP_006722165.1|ensembl:ENSG00000161692(gene)|ensembl:ENST00000315005(transcript)|go:"GO:0003676"(nucleic acid binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0007049"(cell cycle)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010971"(positive regulation of G2/M transition of mitotic cell cycle)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030295"(protein kinase activator activity)|go:"GO:0031431"(Dbf4-dependent protein kinase complex)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:1901987"(regulation of cell cycle phase transition)|interpro:IPR006572(Zinc finger, DBF-type)|interpro:IPR038545|mint:Q8NFT6|go:"GO:0010571"(positive regulation of nuclear cell cycle DNA replication)	refseq:NP_003325.2|refseq:NP_695012.1|refseq:XP_016885269.1|refseq:XP_016885270.1|dip:DIP-33686N|ensembl:ENSG00000130985(gene)|ensembl:ENST00000335972(transcript)|ensembl:ENST00000377351(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0004839"(ubiquitin activating enzyme activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0032446"(protein modification by small protein conjugation)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000011(Ubiquitin-activating enzyme, E1)|interpro:IPR000594(UBA/THIF-type NAD/FAD binding fold)|interpro:IPR018074|interpro:IPR018075|interpro:IPR018965|interpro:IPR019572|interpro:IPR032418|interpro:IPR032420|interpro:IPR033127|interpro:IPR035985|interpro:IPR038252|interpro:IPR042063|interpro:IPR042302|interpro:IPR042449|mint:P22314|rcsb pdb:4P22|rcsb pdb:6DC6|reactome:R-HSA-8866652|reactome:R-HSA-983168	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S2|caution:"UBE2N has been marked as the enzyme in this assay, although it is the UBE2N-UBE2V1 complex that has ubiquitinase (E3) activity. Neither UBE2N nor UBE2V1 have E2 or E3 activity on their own."|resulting-ptm:Q8NFT6 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:BdvmDAqRsWqg1qbvLLc/uVtXEiI9606	rogid:q+vEeA0XLST0Zz173bmEt0dNbDE9606	intact-crc:BE59E3CDA1038102|rigid:wgrBIg/kfTyVpGndBifPC5m2zRs	false	-	his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q8NFT6	uniprotkb:P61088	intact:EBI-749662|uniprotkb:Q8TEX0|uniprotkb:Q9H912|uniprotkb:Q96B19|uniprotkb:D3DX56|ensembl:ENSP00000323663	intact:EBI-1052908|uniprotkb:Q16781|uniprotkb:Q53Y81|ensembl:ENSP00000316176	psi-mi:dbf4b_human(display_long)|uniprotkb:ASKL1(gene name synonym)|uniprotkb:DRF1(gene name synonym)|uniprotkb:Activator of S phase kinase-like protein 1(gene name synonym)|uniprotkb:Dbf4-related factor 1(gene name synonym)|uniprotkb:Chiffon homolog B(gene name synonym)|uniprotkb:DBF4B(gene name)|psi-mi:DBF4B(display_short)	psi-mi:ube2n_human(display_long)|uniprotkb:Ubiquitin-protein ligase N(gene name synonym)|uniprotkb:Ubiquitin carrier protein N(gene name synonym)|uniprotkb:Ubc13(gene name synonym)|uniprotkb:Bendless-like ubiquitin-conjugating enzyme(gene name synonym)|uniprotkb:UBE2N(gene name)|psi-mi:UBE2N(display_short)|uniprotkb:BLU(gene name synonym)|uniprotkb:UbcH13(gene name synonym)|uniprotkb:E2 ubiquitin-conjugating enzyme N(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9970873|imex:IM-22822-46	author-confidence:Z-score = 6.78	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_079380.2|refseq:NP_663696.1|refseq:XP_011523583.1|refseq:XP_006722165.1|ensembl:ENSG00000161692(gene)|ensembl:ENST00000315005(transcript)|go:"GO:0003676"(nucleic acid binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0007049"(cell cycle)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010971"(positive regulation of G2/M transition of mitotic cell cycle)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030295"(protein kinase activator activity)|go:"GO:0031431"(Dbf4-dependent protein kinase complex)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:1901987"(regulation of cell cycle phase transition)|interpro:IPR006572(Zinc finger, DBF-type)|interpro:IPR038545|mint:Q8NFT6|go:"GO:0010571"(positive regulation of nuclear cell cycle DNA replication)	refseq:NP_003339.1|dip:DIP-29829N|ensembl:ENSG00000177889(gene)|ensembl:ENST00000318066(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000729"(DNA double-strand break processing)|go:"GO:0001650"(fibrillar center)|go:"GO:0003723"(RNA binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006282"(regulation of DNA repair)|go:"GO:0006301"(postreplication repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016574"(histone ubiquitination)|go:"GO:0031058"(positive regulation of histone modification)|go:"GO:0031372"(UBC13-MMS2 complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033182"(regulation of histone ubiquitination)|go:"GO:0035370"(UBC13-UEV1A complex)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0061631"(ubiquitin conjugating enzyme activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070534"(protein K63-linked ubiquitination)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|interpro:IPR023313|rcsb pdb:1J7D|rcsb pdb:2C2V|rcsb pdb:3HCT|rcsb pdb:3HCU|rcsb pdb:3VON|rcsb pdb:3W31|rcsb pdb:4DHI|rcsb pdb:4DHJ|rcsb pdb:4DHZ|rcsb pdb:4IP3|rcsb pdb:4NR3|rcsb pdb:4NRG|rcsb pdb:4NRI|rcsb pdb:4ONL|rcsb pdb:4ONM|rcsb pdb:4ONN|rcsb pdb:4ORH|rcsb pdb:4TKP|rcsb pdb:4WHV|rcsb pdb:5AIT|rcsb pdb:5AIU|rcsb pdb:5EYA|rcsb pdb:5H7S|rcsb pdb:5VNZ|rcsb pdb:5VO0|rcsb pdb:5YWR|rcsb pdb:6D6I|rcsb pdb:6JKY|rcsb pdb:6KFP|rcsb pdb:6KG6|rcsb pdb:6KL4|rcsb pdb:6LP2|rcsb pdb:6P5B|rcsb pdb:6S53|reactome:R-HSA-168927|reactome:R-HSA-202424|reactome:R-HSA-2871837|reactome:R-HSA-445989|reactome:R-HSA-450302|reactome:R-HSA-450321|reactome:R-HSA-5607764|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-5696395|reactome:R-HSA-69473|reactome:R-HSA-8866654|reactome:R-HSA-9020702|reactome:R-HSA-937039|reactome:R-HSA-937041|reactome:R-HSA-9646399|reactome:R-HSA-975110|reactome:R-HSA-975144|reactome:R-HSA-983168|rcsb pdb:6ULH|rcsb pdb:6UMP|rcsb pdb:6UMS|rcsb pdb:7BBD|rcsb pdb:7BBF|rcsb pdb:7BXG|reactome:R-HSA-1169408|reactome:R-HSA-168638	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S2|caution:"UBE2N has been marked as the enzyme in this assay, although it is the UBE2N-UBE2V1 complex that has ubiquitinase (E3) activity. Neither UBE2N nor UBE2V1 have E2 or E3 activity on their own."|resulting-ptm:Q8NFT6 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:BdvmDAqRsWqg1qbvLLc/uVtXEiI9606	rogid:dqdszHlq5FLPHC6UWX6uvkC6Yz89606	intact-crc:BE59E3CDA1038102|rigid:wgrBIg/kfTyVpGndBifPC5m2zRs	false	-	his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q8TEB9	uniprotkb:Q13404	intact:EBI-9916444|uniprotkb:Q8IV60|uniprotkb:Q53S43|uniprotkb:Q5EBM8|uniprotkb:Q495B9|uniprotkb:Q6P5V8|uniprotkb:Q9H057|ensembl:ENSP00000344779|ensembl:ENSP00000375914|intact:EBI-28982195	intact:EBI-1050671|uniprotkb:Q13403|uniprotkb:Q13532|uniprotkb:Q96H34|uniprotkb:Q9GZT0|uniprotkb:Q9GZW1|uniprotkb:Q9H4J3|uniprotkb:Q9H4J4|uniprotkb:Q9UKL1|uniprotkb:Q9UM48|uniprotkb:Q9UM49|uniprotkb:Q9UM50|uniprotkb:Q5TGE3|uniprotkb:E1P629|uniprotkb:Q5TGE0|ensembl:ENSP00000360739	psi-mi:rhbl4_human(display_long)|uniprotkb:RHBDL4(gene name synonym)|uniprotkb:Rhomboid domain-containing protein 1(gene name synonym)|uniprotkb:Rhomboid-like protein 4(gene name synonym)|uniprotkb:HSD-50(orf name)|uniprotkb:HSD50(orf name)|uniprotkb:RHBDD1(gene name)|psi-mi:RHBDD1(display_short)	psi-mi:ub2v1_human(display_long)|uniprotkb:CROC-1(gene name synonym)|uniprotkb:TRAF6-regulated IKK activator 1 beta Uev1A(gene name synonym)|uniprotkb:P/OKcl.19(orf name)|uniprotkb:UBE2V1(gene name)|psi-mi:UBE2V1(display_short)|uniprotkb:CROC1(gene name synonym)|uniprotkb:UBE2V(gene name synonym)|uniprotkb:UEV1(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9970894|imex:IM-22822-47	author-confidence:Z-score = 3.43	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSP00000344779|ensembl:ENSP00000375914|refseq:NP_001161080.1|refseq:NP_115652.2|refseq:XP_016860572.1|refseq:XP_016860573.1|refseq:XP_016860574.1|refseq:XP_016860575.1|refseq:XP_016860576.1|refseq:XP_016860577.1|refseq:XP_016860578.1|refseq:XP_016860579.1|refseq:XP_016860580.1|refseq:XP_016860581.1|ensembl:ENSG00000144468(gene)|ensembl:ENST00000341329(transcript)|ensembl:ENST00000392062(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0010954"(positive regulation of protein processing)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0031293"(membrane protein intracellular domain proteolysis)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0033619"(membrane protein proteolysis)|go:"GO:0034620"(cellular response to unfolded protein)|go:"GO:0034644"(cellular response to UV)|go:"GO:0036503"(ERAD pathway)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043687"(post-translational protein modification)|go:"GO:0044322"(endoplasmic reticulum quality control compartment)|go:"GO:0048515"(spermatid differentiation)|go:"GO:0051047"(positive regulation of secretion)|go:"GO:1904211"(membrane protein proteolysis involved in retrograde protein transport, ER to cytosol)|interpro:IPR022764|interpro:IPR035952|rcsb pdb:5EPP|go:"GO:0045732"(positive regulation of protein catabolic process)	refseq:NP_001027459.1|refseq:NP_068823.2|refseq:NP_071887.1|refseq:NP_954595.1|refseq:NP_954673.1|refseq:NP_001244322.1|refseq:NP_001244323.1|refseq:NP_001244325.1|ensembl:ENSG00000244687(gene)|ensembl:ENST00000371674(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006282"(regulation of DNA repair)|go:"GO:0006301"(postreplication repair)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0030154"(cell differentiation)|go:"GO:0031371"(ubiquitin conjugating enzyme complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035370"(UBC13-UEV1A complex)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070534"(protein K63-linked ubiquitination)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|rcsb pdb:2A4D|rcsb pdb:2C2V|rcsb pdb:2HLW|rcsb pdb:6D6I|reactome:R-HSA-168638|reactome:R-HSA-168927|reactome:R-HSA-202424|reactome:R-HSA-2871837|reactome:R-HSA-445989|reactome:R-HSA-450302|reactome:R-HSA-450321|reactome:R-HSA-5607764|reactome:R-HSA-9020702|reactome:R-HSA-937039|reactome:R-HSA-937041|reactome:R-HSA-9646399|reactome:R-HSA-975110|reactome:R-HSA-975144|reactome:R-HSA-983168|dip:DIP-41911N	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S2|caution:"UBE2N has been marked as the enzyme in this assay, although it is the UBE2N-UBE2V1 complex that has ubiquitinase (E3) activity. Neither UBE2N nor UBE2V1 have E2 or E3 activity on their own."|resulting-ptm:Q8TEB9 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:SlP71PmrPHFnC5EcRuzD9NjO7/09606	rogid:x95N7Dj2KIqu5gySX59xLmfthUg9606	intact-crc:1F68536B4C54ABAE|rigid:NyeqLPExa/b7h6hDS6E/dJzl0z8	false	-	his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q8TEB9	uniprotkb:P22314	intact:EBI-9916444|uniprotkb:Q8IV60|uniprotkb:Q53S43|uniprotkb:Q5EBM8|uniprotkb:Q495B9|uniprotkb:Q6P5V8|uniprotkb:Q9H057|ensembl:ENSP00000344779|ensembl:ENSP00000375914|intact:EBI-28982195	intact:EBI-709688|uniprotkb:Q96E13|uniprotkb:Q5JRR8|ensembl:ENSP00000338413|ensembl:ENSP00000366568	psi-mi:rhbl4_human(display_long)|uniprotkb:RHBDL4(gene name synonym)|uniprotkb:Rhomboid domain-containing protein 1(gene name synonym)|uniprotkb:Rhomboid-like protein 4(gene name synonym)|uniprotkb:HSD-50(orf name)|uniprotkb:HSD50(orf name)|uniprotkb:RHBDD1(gene name)|psi-mi:RHBDD1(display_short)	psi-mi:uba1_human(display_long)|uniprotkb:Ubiquitin-activating enzyme E1(gene name synonym)|uniprotkb:Protein A1S9(gene name synonym)|uniprotkb:UBA1(gene name)|psi-mi:UBA1(display_short)|uniprotkb:A1S9T(gene name synonym)|uniprotkb:UBE1(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9970894|imex:IM-22822-47	author-confidence:Z-score = 3.43	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSP00000344779|ensembl:ENSP00000375914|refseq:NP_001161080.1|refseq:NP_115652.2|refseq:XP_016860572.1|refseq:XP_016860573.1|refseq:XP_016860574.1|refseq:XP_016860575.1|refseq:XP_016860576.1|refseq:XP_016860577.1|refseq:XP_016860578.1|refseq:XP_016860579.1|refseq:XP_016860580.1|refseq:XP_016860581.1|ensembl:ENSG00000144468(gene)|ensembl:ENST00000341329(transcript)|ensembl:ENST00000392062(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0010954"(positive regulation of protein processing)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0031293"(membrane protein intracellular domain proteolysis)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0033619"(membrane protein proteolysis)|go:"GO:0034620"(cellular response to unfolded protein)|go:"GO:0034644"(cellular response to UV)|go:"GO:0036503"(ERAD pathway)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043687"(post-translational protein modification)|go:"GO:0044322"(endoplasmic reticulum quality control compartment)|go:"GO:0048515"(spermatid differentiation)|go:"GO:0051047"(positive regulation of secretion)|go:"GO:1904211"(membrane protein proteolysis involved in retrograde protein transport, ER to cytosol)|interpro:IPR022764|interpro:IPR035952|rcsb pdb:5EPP|go:"GO:0045732"(positive regulation of protein catabolic process)	refseq:NP_003325.2|refseq:NP_695012.1|refseq:XP_016885269.1|refseq:XP_016885270.1|dip:DIP-33686N|ensembl:ENSG00000130985(gene)|ensembl:ENST00000335972(transcript)|ensembl:ENST00000377351(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0004839"(ubiquitin activating enzyme activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0032446"(protein modification by small protein conjugation)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000011(Ubiquitin-activating enzyme, E1)|interpro:IPR000594(UBA/THIF-type NAD/FAD binding fold)|interpro:IPR018074|interpro:IPR018075|interpro:IPR018965|interpro:IPR019572|interpro:IPR032418|interpro:IPR032420|interpro:IPR033127|interpro:IPR035985|interpro:IPR038252|interpro:IPR042063|interpro:IPR042302|interpro:IPR042449|mint:P22314|rcsb pdb:4P22|rcsb pdb:6DC6|reactome:R-HSA-8866652|reactome:R-HSA-983168	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S2|caution:"UBE2N has been marked as the enzyme in this assay, although it is the UBE2N-UBE2V1 complex that has ubiquitinase (E3) activity. Neither UBE2N nor UBE2V1 have E2 or E3 activity on their own."|resulting-ptm:Q8TEB9 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:SlP71PmrPHFnC5EcRuzD9NjO7/09606	rogid:q+vEeA0XLST0Zz173bmEt0dNbDE9606	intact-crc:1F68536B4C54ABAE|rigid:NyeqLPExa/b7h6hDS6E/dJzl0z8	false	-	his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q8TEB9	uniprotkb:P61088	intact:EBI-9916444|uniprotkb:Q8IV60|uniprotkb:Q53S43|uniprotkb:Q5EBM8|uniprotkb:Q495B9|uniprotkb:Q6P5V8|uniprotkb:Q9H057|ensembl:ENSP00000344779|ensembl:ENSP00000375914|intact:EBI-28982195	intact:EBI-1052908|uniprotkb:Q16781|uniprotkb:Q53Y81|ensembl:ENSP00000316176	psi-mi:rhbl4_human(display_long)|uniprotkb:RHBDL4(gene name synonym)|uniprotkb:Rhomboid domain-containing protein 1(gene name synonym)|uniprotkb:Rhomboid-like protein 4(gene name synonym)|uniprotkb:HSD-50(orf name)|uniprotkb:HSD50(orf name)|uniprotkb:RHBDD1(gene name)|psi-mi:RHBDD1(display_short)	psi-mi:ube2n_human(display_long)|uniprotkb:Ubiquitin-protein ligase N(gene name synonym)|uniprotkb:Ubiquitin carrier protein N(gene name synonym)|uniprotkb:Ubc13(gene name synonym)|uniprotkb:Bendless-like ubiquitin-conjugating enzyme(gene name synonym)|uniprotkb:UBE2N(gene name)|psi-mi:UBE2N(display_short)|uniprotkb:BLU(gene name synonym)|uniprotkb:UbcH13(gene name synonym)|uniprotkb:E2 ubiquitin-conjugating enzyme N(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9970894|imex:IM-22822-47	author-confidence:Z-score = 3.43	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSP00000344779|ensembl:ENSP00000375914|refseq:NP_001161080.1|refseq:NP_115652.2|refseq:XP_016860572.1|refseq:XP_016860573.1|refseq:XP_016860574.1|refseq:XP_016860575.1|refseq:XP_016860576.1|refseq:XP_016860577.1|refseq:XP_016860578.1|refseq:XP_016860579.1|refseq:XP_016860580.1|refseq:XP_016860581.1|ensembl:ENSG00000144468(gene)|ensembl:ENST00000341329(transcript)|ensembl:ENST00000392062(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0010954"(positive regulation of protein processing)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0031293"(membrane protein intracellular domain proteolysis)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0033619"(membrane protein proteolysis)|go:"GO:0034620"(cellular response to unfolded protein)|go:"GO:0034644"(cellular response to UV)|go:"GO:0036503"(ERAD pathway)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043687"(post-translational protein modification)|go:"GO:0044322"(endoplasmic reticulum quality control compartment)|go:"GO:0048515"(spermatid differentiation)|go:"GO:0051047"(positive regulation of secretion)|go:"GO:1904211"(membrane protein proteolysis involved in retrograde protein transport, ER to cytosol)|interpro:IPR022764|interpro:IPR035952|rcsb pdb:5EPP|go:"GO:0045732"(positive regulation of protein catabolic process)	refseq:NP_003339.1|dip:DIP-29829N|ensembl:ENSG00000177889(gene)|ensembl:ENST00000318066(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000729"(DNA double-strand break processing)|go:"GO:0001650"(fibrillar center)|go:"GO:0003723"(RNA binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006282"(regulation of DNA repair)|go:"GO:0006301"(postreplication repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016574"(histone ubiquitination)|go:"GO:0031058"(positive regulation of histone modification)|go:"GO:0031372"(UBC13-MMS2 complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033182"(regulation of histone ubiquitination)|go:"GO:0035370"(UBC13-UEV1A complex)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0061631"(ubiquitin conjugating enzyme activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070534"(protein K63-linked ubiquitination)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|interpro:IPR023313|rcsb pdb:1J7D|rcsb pdb:2C2V|rcsb pdb:3HCT|rcsb pdb:3HCU|rcsb pdb:3VON|rcsb pdb:3W31|rcsb pdb:4DHI|rcsb pdb:4DHJ|rcsb pdb:4DHZ|rcsb pdb:4IP3|rcsb pdb:4NR3|rcsb pdb:4NRG|rcsb pdb:4NRI|rcsb pdb:4ONL|rcsb pdb:4ONM|rcsb pdb:4ONN|rcsb pdb:4ORH|rcsb pdb:4TKP|rcsb pdb:4WHV|rcsb pdb:5AIT|rcsb pdb:5AIU|rcsb pdb:5EYA|rcsb pdb:5H7S|rcsb pdb:5VNZ|rcsb pdb:5VO0|rcsb pdb:5YWR|rcsb pdb:6D6I|rcsb pdb:6JKY|rcsb pdb:6KFP|rcsb pdb:6KG6|rcsb pdb:6KL4|rcsb pdb:6LP2|rcsb pdb:6P5B|rcsb pdb:6S53|reactome:R-HSA-168927|reactome:R-HSA-202424|reactome:R-HSA-2871837|reactome:R-HSA-445989|reactome:R-HSA-450302|reactome:R-HSA-450321|reactome:R-HSA-5607764|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-5696395|reactome:R-HSA-69473|reactome:R-HSA-8866654|reactome:R-HSA-9020702|reactome:R-HSA-937039|reactome:R-HSA-937041|reactome:R-HSA-9646399|reactome:R-HSA-975110|reactome:R-HSA-975144|reactome:R-HSA-983168|rcsb pdb:6ULH|rcsb pdb:6UMP|rcsb pdb:6UMS|rcsb pdb:7BBD|rcsb pdb:7BBF|rcsb pdb:7BXG|reactome:R-HSA-1169408|reactome:R-HSA-168638	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S2|caution:"UBE2N has been marked as the enzyme in this assay, although it is the UBE2N-UBE2V1 complex that has ubiquitinase (E3) activity. Neither UBE2N nor UBE2V1 have E2 or E3 activity on their own."|resulting-ptm:Q8TEB9 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:SlP71PmrPHFnC5EcRuzD9NjO7/09606	rogid:dqdszHlq5FLPHC6UWX6uvkC6Yz89606	intact-crc:1F68536B4C54ABAE|rigid:NyeqLPExa/b7h6hDS6E/dJzl0z8	false	-	his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q8N6D2	uniprotkb:Q13404	intact:EBI-2130099|uniprotkb:B2RDG2|uniprotkb:Q8NBG3|ensembl:ENSP00000420465|ensembl:ENSP00000441271|ensembl:ENSP00000442021|ensembl:ENSP00000443228	intact:EBI-1050671|uniprotkb:Q13403|uniprotkb:Q13532|uniprotkb:Q96H34|uniprotkb:Q9GZT0|uniprotkb:Q9GZW1|uniprotkb:Q9H4J3|uniprotkb:Q9H4J4|uniprotkb:Q9UKL1|uniprotkb:Q9UM48|uniprotkb:Q9UM49|uniprotkb:Q9UM50|uniprotkb:Q5TGE3|uniprotkb:E1P629|uniprotkb:Q5TGE0|ensembl:ENSP00000360739	psi-mi:rn182_human(display_long)|uniprotkb:RNF182(gene name)|psi-mi:RNF182(display_short)|uniprotkb:RING finger protein 182(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase RNF182(gene name synonym)	psi-mi:ub2v1_human(display_long)|uniprotkb:CROC-1(gene name synonym)|uniprotkb:TRAF6-regulated IKK activator 1 beta Uev1A(gene name synonym)|uniprotkb:P/OKcl.19(orf name)|uniprotkb:UBE2V1(gene name)|psi-mi:UBE2V1(display_short)|uniprotkb:CROC1(gene name synonym)|uniprotkb:UBE2V(gene name synonym)|uniprotkb:UEV1(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9970852|imex:IM-22822-45	author-confidence:Z-score = 3.02	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001158504.1|refseq:NP_001158505.1|refseq:NP_001158506.1|refseq:NP_689950.1|refseq:XP_016865937.1|refseq:XP_016865938.1|refseq:XP_016865939.1|ensembl:ENSG00000180537(gene)|ensembl:ENST00000488300(transcript)|ensembl:ENST00000537388(transcript)|ensembl:ENST00000537663(transcript)|ensembl:ENST00000544682(transcript)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0046872"(metal ion binding)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR042285|reactome:R-HSA-983168	refseq:NP_001027459.1|refseq:NP_068823.2|refseq:NP_071887.1|refseq:NP_954595.1|refseq:NP_954673.1|refseq:NP_001244322.1|refseq:NP_001244323.1|refseq:NP_001244325.1|ensembl:ENSG00000244687(gene)|ensembl:ENST00000371674(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006282"(regulation of DNA repair)|go:"GO:0006301"(postreplication repair)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0030154"(cell differentiation)|go:"GO:0031371"(ubiquitin conjugating enzyme complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035370"(UBC13-UEV1A complex)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070534"(protein K63-linked ubiquitination)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|rcsb pdb:2A4D|rcsb pdb:2C2V|rcsb pdb:2HLW|rcsb pdb:6D6I|reactome:R-HSA-168638|reactome:R-HSA-168927|reactome:R-HSA-202424|reactome:R-HSA-2871837|reactome:R-HSA-445989|reactome:R-HSA-450302|reactome:R-HSA-450321|reactome:R-HSA-5607764|reactome:R-HSA-9020702|reactome:R-HSA-937039|reactome:R-HSA-937041|reactome:R-HSA-9646399|reactome:R-HSA-975110|reactome:R-HSA-975144|reactome:R-HSA-983168|dip:DIP-41911N	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S2|caution:"UBE2N has been marked as the enzyme in this assay, although it is the UBE2N-UBE2V1 complex that has ubiquitinase (E3) activity. Neither UBE2N nor UBE2V1 have E2 or E3 activity on their own."|resulting-ptm:Q8N6D2 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:bFOqwutKRZE1WJIcpkKCx8so9WU9606	rogid:x95N7Dj2KIqu5gySX59xLmfthUg9606	intact-crc:89016F6CAD7644F1|rigid:SM3Lbqtnd7udlWonqFZy1oRyfM4	false	-	his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q8N6D2	uniprotkb:P22314	intact:EBI-2130099|uniprotkb:B2RDG2|uniprotkb:Q8NBG3|ensembl:ENSP00000420465|ensembl:ENSP00000441271|ensembl:ENSP00000442021|ensembl:ENSP00000443228	intact:EBI-709688|uniprotkb:Q96E13|uniprotkb:Q5JRR8|ensembl:ENSP00000338413|ensembl:ENSP00000366568	psi-mi:rn182_human(display_long)|uniprotkb:RNF182(gene name)|psi-mi:RNF182(display_short)|uniprotkb:RING finger protein 182(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase RNF182(gene name synonym)	psi-mi:uba1_human(display_long)|uniprotkb:Ubiquitin-activating enzyme E1(gene name synonym)|uniprotkb:Protein A1S9(gene name synonym)|uniprotkb:UBA1(gene name)|psi-mi:UBA1(display_short)|uniprotkb:A1S9T(gene name synonym)|uniprotkb:UBE1(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9970852|imex:IM-22822-45	author-confidence:Z-score = 3.02	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001158504.1|refseq:NP_001158505.1|refseq:NP_001158506.1|refseq:NP_689950.1|refseq:XP_016865937.1|refseq:XP_016865938.1|refseq:XP_016865939.1|ensembl:ENSG00000180537(gene)|ensembl:ENST00000488300(transcript)|ensembl:ENST00000537388(transcript)|ensembl:ENST00000537663(transcript)|ensembl:ENST00000544682(transcript)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0046872"(metal ion binding)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR042285|reactome:R-HSA-983168	refseq:NP_003325.2|refseq:NP_695012.1|refseq:XP_016885269.1|refseq:XP_016885270.1|dip:DIP-33686N|ensembl:ENSG00000130985(gene)|ensembl:ENST00000335972(transcript)|ensembl:ENST00000377351(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0004839"(ubiquitin activating enzyme activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0032446"(protein modification by small protein conjugation)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000011(Ubiquitin-activating enzyme, E1)|interpro:IPR000594(UBA/THIF-type NAD/FAD binding fold)|interpro:IPR018074|interpro:IPR018075|interpro:IPR018965|interpro:IPR019572|interpro:IPR032418|interpro:IPR032420|interpro:IPR033127|interpro:IPR035985|interpro:IPR038252|interpro:IPR042063|interpro:IPR042302|interpro:IPR042449|mint:P22314|rcsb pdb:4P22|rcsb pdb:6DC6|reactome:R-HSA-8866652|reactome:R-HSA-983168	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S2|caution:"UBE2N has been marked as the enzyme in this assay, although it is the UBE2N-UBE2V1 complex that has ubiquitinase (E3) activity. Neither UBE2N nor UBE2V1 have E2 or E3 activity on their own."|resulting-ptm:Q8N6D2 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:bFOqwutKRZE1WJIcpkKCx8so9WU9606	rogid:q+vEeA0XLST0Zz173bmEt0dNbDE9606	intact-crc:89016F6CAD7644F1|rigid:SM3Lbqtnd7udlWonqFZy1oRyfM4	false	-	his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q8N6D2	uniprotkb:P61088	intact:EBI-2130099|uniprotkb:B2RDG2|uniprotkb:Q8NBG3|ensembl:ENSP00000420465|ensembl:ENSP00000441271|ensembl:ENSP00000442021|ensembl:ENSP00000443228	intact:EBI-1052908|uniprotkb:Q16781|uniprotkb:Q53Y81|ensembl:ENSP00000316176	psi-mi:rn182_human(display_long)|uniprotkb:RNF182(gene name)|psi-mi:RNF182(display_short)|uniprotkb:RING finger protein 182(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase RNF182(gene name synonym)	psi-mi:ube2n_human(display_long)|uniprotkb:Ubiquitin-protein ligase N(gene name synonym)|uniprotkb:Ubiquitin carrier protein N(gene name synonym)|uniprotkb:Ubc13(gene name synonym)|uniprotkb:Bendless-like ubiquitin-conjugating enzyme(gene name synonym)|uniprotkb:UBE2N(gene name)|psi-mi:UBE2N(display_short)|uniprotkb:BLU(gene name synonym)|uniprotkb:UbcH13(gene name synonym)|uniprotkb:E2 ubiquitin-conjugating enzyme N(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9970852|imex:IM-22822-45	author-confidence:Z-score = 3.02	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001158504.1|refseq:NP_001158505.1|refseq:NP_001158506.1|refseq:NP_689950.1|refseq:XP_016865937.1|refseq:XP_016865938.1|refseq:XP_016865939.1|ensembl:ENSG00000180537(gene)|ensembl:ENST00000488300(transcript)|ensembl:ENST00000537388(transcript)|ensembl:ENST00000537663(transcript)|ensembl:ENST00000544682(transcript)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0046872"(metal ion binding)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR042285|reactome:R-HSA-983168	refseq:NP_003339.1|dip:DIP-29829N|ensembl:ENSG00000177889(gene)|ensembl:ENST00000318066(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000729"(DNA double-strand break processing)|go:"GO:0001650"(fibrillar center)|go:"GO:0003723"(RNA binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006282"(regulation of DNA repair)|go:"GO:0006301"(postreplication repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016574"(histone ubiquitination)|go:"GO:0031058"(positive regulation of histone modification)|go:"GO:0031372"(UBC13-MMS2 complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033182"(regulation of histone ubiquitination)|go:"GO:0035370"(UBC13-UEV1A complex)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0061631"(ubiquitin conjugating enzyme activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070534"(protein K63-linked ubiquitination)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|interpro:IPR023313|rcsb pdb:1J7D|rcsb pdb:2C2V|rcsb pdb:3HCT|rcsb pdb:3HCU|rcsb pdb:3VON|rcsb pdb:3W31|rcsb pdb:4DHI|rcsb pdb:4DHJ|rcsb pdb:4DHZ|rcsb pdb:4IP3|rcsb pdb:4NR3|rcsb pdb:4NRG|rcsb pdb:4NRI|rcsb pdb:4ONL|rcsb pdb:4ONM|rcsb pdb:4ONN|rcsb pdb:4ORH|rcsb pdb:4TKP|rcsb pdb:4WHV|rcsb pdb:5AIT|rcsb pdb:5AIU|rcsb pdb:5EYA|rcsb pdb:5H7S|rcsb pdb:5VNZ|rcsb pdb:5VO0|rcsb pdb:5YWR|rcsb pdb:6D6I|rcsb pdb:6JKY|rcsb pdb:6KFP|rcsb pdb:6KG6|rcsb pdb:6KL4|rcsb pdb:6LP2|rcsb pdb:6P5B|rcsb pdb:6S53|reactome:R-HSA-168927|reactome:R-HSA-202424|reactome:R-HSA-2871837|reactome:R-HSA-445989|reactome:R-HSA-450302|reactome:R-HSA-450321|reactome:R-HSA-5607764|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-5696395|reactome:R-HSA-69473|reactome:R-HSA-8866654|reactome:R-HSA-9020702|reactome:R-HSA-937039|reactome:R-HSA-937041|reactome:R-HSA-9646399|reactome:R-HSA-975110|reactome:R-HSA-975144|reactome:R-HSA-983168|rcsb pdb:6ULH|rcsb pdb:6UMP|rcsb pdb:6UMS|rcsb pdb:7BBD|rcsb pdb:7BBF|rcsb pdb:7BXG|reactome:R-HSA-1169408|reactome:R-HSA-168638	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S2|caution:"UBE2N has been marked as the enzyme in this assay, although it is the UBE2N-UBE2V1 complex that has ubiquitinase (E3) activity. Neither UBE2N nor UBE2V1 have E2 or E3 activity on their own."|resulting-ptm:Q8N6D2 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:bFOqwutKRZE1WJIcpkKCx8so9WU9606	rogid:dqdszHlq5FLPHC6UWX6uvkC6Yz89606	intact-crc:89016F6CAD7644F1|rigid:SM3Lbqtnd7udlWonqFZy1oRyfM4	false	-	his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q969K3	uniprotkb:Q13404	intact:EBI-2340642|uniprotkb:Q8NG47|uniprotkb:Q9H6W8|uniprotkb:B7Z933|ensembl:ENSP00000355137	intact:EBI-1050671|uniprotkb:Q13403|uniprotkb:Q13532|uniprotkb:Q96H34|uniprotkb:Q9GZT0|uniprotkb:Q9GZW1|uniprotkb:Q9H4J3|uniprotkb:Q9H4J4|uniprotkb:Q9UKL1|uniprotkb:Q9UM48|uniprotkb:Q9UM49|uniprotkb:Q9UM50|uniprotkb:Q5TGE3|uniprotkb:E1P629|uniprotkb:Q5TGE0|ensembl:ENSP00000360739	psi-mi:rnf34_human(display_long)|uniprotkb:RNF34(gene name)|psi-mi:RNF34(display_short)|uniprotkb:RING finger protein 34(gene name synonym)|uniprotkb:RING finger protein RIFF(gene name synonym)|uniprotkb:FYVE-RING finger protein Momo(gene name synonym)|uniprotkb:Human RING finger homologous to inhibitor of apoptosis protein(gene name synonym)|uniprotkb:Caspases-8 and -10-associated RING finger protein 1(gene name synonym)|uniprotkb:Caspase regulator CARP1(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase RNF34(gene name synonym)	psi-mi:ub2v1_human(display_long)|uniprotkb:CROC-1(gene name synonym)|uniprotkb:TRAF6-regulated IKK activator 1 beta Uev1A(gene name synonym)|uniprotkb:P/OKcl.19(orf name)|uniprotkb:UBE2V1(gene name)|psi-mi:UBE2V1(display_short)|uniprotkb:CROC1(gene name synonym)|uniprotkb:UBE2V(gene name synonym)|uniprotkb:UEV1(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9970915|imex:IM-22822-48	author-confidence:Z-score = 18.63|author-confidence:Z-score = 18.69	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001243787.1|refseq:NP_079402.2|refseq:NP_919247.1|ensembl:ENSG00000170633(gene)|ensembl:ENST00000361234(transcript)|go:"GO:0002039"(p53 binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006915"(apoptotic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0035872"(nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070936"(protein K48-linked ubiquitination)|go:"GO:1901796"(regulation of signal transduction by p53 class mediator)|go:"GO:1901797"(negative regulation of signal transduction by p53 class mediator)|go:"GO:1901981"(phosphatidylinositol phosphate binding)|go:"GO:1902042"(negative regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:2000374"(regulation of oxygen metabolic process)|go:"GO:2001271"(negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR036361|mint:Q969K3|reactome:R-HSA-6804757|reactome:R-HSA-983168	refseq:NP_001027459.1|refseq:NP_068823.2|refseq:NP_071887.1|refseq:NP_954595.1|refseq:NP_954673.1|refseq:NP_001244322.1|refseq:NP_001244323.1|refseq:NP_001244325.1|ensembl:ENSG00000244687(gene)|ensembl:ENST00000371674(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006282"(regulation of DNA repair)|go:"GO:0006301"(postreplication repair)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0030154"(cell differentiation)|go:"GO:0031371"(ubiquitin conjugating enzyme complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035370"(UBC13-UEV1A complex)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070534"(protein K63-linked ubiquitination)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|rcsb pdb:2A4D|rcsb pdb:2C2V|rcsb pdb:2HLW|rcsb pdb:6D6I|reactome:R-HSA-168638|reactome:R-HSA-168927|reactome:R-HSA-202424|reactome:R-HSA-2871837|reactome:R-HSA-445989|reactome:R-HSA-450302|reactome:R-HSA-450321|reactome:R-HSA-5607764|reactome:R-HSA-9020702|reactome:R-HSA-937039|reactome:R-HSA-937041|reactome:R-HSA-9646399|reactome:R-HSA-975110|reactome:R-HSA-975144|reactome:R-HSA-983168|dip:DIP-41911N	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S2|caution:"UBE2N has been marked as the enzyme in this assay, although it is the UBE2N-UBE2V1 complex that has ubiquitinase (E3) activity. Neither UBE2N nor UBE2V1 have E2 or E3 activity on their own."|resulting-ptm:Q969K3 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:pvINlXbJ9UfZbyW4YqRO+HQsCnw9606	rogid:x95N7Dj2KIqu5gySX59xLmfthUg9606	intact-crc:54588D89143EFB78|rigid:Ki/tyFtfGz2BZOcP9T0Bk8/r2LA	false	-	his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q969K3	uniprotkb:P22314	intact:EBI-2340642|uniprotkb:Q8NG47|uniprotkb:Q9H6W8|uniprotkb:B7Z933|ensembl:ENSP00000355137	intact:EBI-709688|uniprotkb:Q96E13|uniprotkb:Q5JRR8|ensembl:ENSP00000338413|ensembl:ENSP00000366568	psi-mi:rnf34_human(display_long)|uniprotkb:RNF34(gene name)|psi-mi:RNF34(display_short)|uniprotkb:RING finger protein 34(gene name synonym)|uniprotkb:RING finger protein RIFF(gene name synonym)|uniprotkb:FYVE-RING finger protein Momo(gene name synonym)|uniprotkb:Human RING finger homologous to inhibitor of apoptosis protein(gene name synonym)|uniprotkb:Caspases-8 and -10-associated RING finger protein 1(gene name synonym)|uniprotkb:Caspase regulator CARP1(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase RNF34(gene name synonym)	psi-mi:uba1_human(display_long)|uniprotkb:Ubiquitin-activating enzyme E1(gene name synonym)|uniprotkb:Protein A1S9(gene name synonym)|uniprotkb:UBA1(gene name)|psi-mi:UBA1(display_short)|uniprotkb:A1S9T(gene name synonym)|uniprotkb:UBE1(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9970915|imex:IM-22822-48	author-confidence:Z-score = 18.63|author-confidence:Z-score = 18.69	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001243787.1|refseq:NP_079402.2|refseq:NP_919247.1|ensembl:ENSG00000170633(gene)|ensembl:ENST00000361234(transcript)|go:"GO:0002039"(p53 binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006915"(apoptotic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0035872"(nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070936"(protein K48-linked ubiquitination)|go:"GO:1901796"(regulation of signal transduction by p53 class mediator)|go:"GO:1901797"(negative regulation of signal transduction by p53 class mediator)|go:"GO:1901981"(phosphatidylinositol phosphate binding)|go:"GO:1902042"(negative regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:2000374"(regulation of oxygen metabolic process)|go:"GO:2001271"(negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR036361|mint:Q969K3|reactome:R-HSA-6804757|reactome:R-HSA-983168	refseq:NP_003325.2|refseq:NP_695012.1|refseq:XP_016885269.1|refseq:XP_016885270.1|dip:DIP-33686N|ensembl:ENSG00000130985(gene)|ensembl:ENST00000335972(transcript)|ensembl:ENST00000377351(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0004839"(ubiquitin activating enzyme activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0032446"(protein modification by small protein conjugation)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000011(Ubiquitin-activating enzyme, E1)|interpro:IPR000594(UBA/THIF-type NAD/FAD binding fold)|interpro:IPR018074|interpro:IPR018075|interpro:IPR018965|interpro:IPR019572|interpro:IPR032418|interpro:IPR032420|interpro:IPR033127|interpro:IPR035985|interpro:IPR038252|interpro:IPR042063|interpro:IPR042302|interpro:IPR042449|mint:P22314|rcsb pdb:4P22|rcsb pdb:6DC6|reactome:R-HSA-8866652|reactome:R-HSA-983168	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S2|caution:"UBE2N has been marked as the enzyme in this assay, although it is the UBE2N-UBE2V1 complex that has ubiquitinase (E3) activity. Neither UBE2N nor UBE2V1 have E2 or E3 activity on their own."|resulting-ptm:Q969K3 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:pvINlXbJ9UfZbyW4YqRO+HQsCnw9606	rogid:q+vEeA0XLST0Zz173bmEt0dNbDE9606	intact-crc:54588D89143EFB78|rigid:Ki/tyFtfGz2BZOcP9T0Bk8/r2LA	false	-	his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q969K3	uniprotkb:P61088	intact:EBI-2340642|uniprotkb:Q8NG47|uniprotkb:Q9H6W8|uniprotkb:B7Z933|ensembl:ENSP00000355137	intact:EBI-1052908|uniprotkb:Q16781|uniprotkb:Q53Y81|ensembl:ENSP00000316176	psi-mi:rnf34_human(display_long)|uniprotkb:RNF34(gene name)|psi-mi:RNF34(display_short)|uniprotkb:RING finger protein 34(gene name synonym)|uniprotkb:RING finger protein RIFF(gene name synonym)|uniprotkb:FYVE-RING finger protein Momo(gene name synonym)|uniprotkb:Human RING finger homologous to inhibitor of apoptosis protein(gene name synonym)|uniprotkb:Caspases-8 and -10-associated RING finger protein 1(gene name synonym)|uniprotkb:Caspase regulator CARP1(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase RNF34(gene name synonym)	psi-mi:ube2n_human(display_long)|uniprotkb:Ubiquitin-protein ligase N(gene name synonym)|uniprotkb:Ubiquitin carrier protein N(gene name synonym)|uniprotkb:Ubc13(gene name synonym)|uniprotkb:Bendless-like ubiquitin-conjugating enzyme(gene name synonym)|uniprotkb:UBE2N(gene name)|psi-mi:UBE2N(display_short)|uniprotkb:BLU(gene name synonym)|uniprotkb:UbcH13(gene name synonym)|uniprotkb:E2 ubiquitin-conjugating enzyme N(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9970915|imex:IM-22822-48	author-confidence:Z-score = 18.63|author-confidence:Z-score = 18.69	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001243787.1|refseq:NP_079402.2|refseq:NP_919247.1|ensembl:ENSG00000170633(gene)|ensembl:ENST00000361234(transcript)|go:"GO:0002039"(p53 binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006915"(apoptotic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0035872"(nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070936"(protein K48-linked ubiquitination)|go:"GO:1901796"(regulation of signal transduction by p53 class mediator)|go:"GO:1901797"(negative regulation of signal transduction by p53 class mediator)|go:"GO:1901981"(phosphatidylinositol phosphate binding)|go:"GO:1902042"(negative regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:2000374"(regulation of oxygen metabolic process)|go:"GO:2001271"(negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR036361|mint:Q969K3|reactome:R-HSA-6804757|reactome:R-HSA-983168	refseq:NP_003339.1|dip:DIP-29829N|ensembl:ENSG00000177889(gene)|ensembl:ENST00000318066(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000729"(DNA double-strand break processing)|go:"GO:0001650"(fibrillar center)|go:"GO:0003723"(RNA binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006282"(regulation of DNA repair)|go:"GO:0006301"(postreplication repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016574"(histone ubiquitination)|go:"GO:0031058"(positive regulation of histone modification)|go:"GO:0031372"(UBC13-MMS2 complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033182"(regulation of histone ubiquitination)|go:"GO:0035370"(UBC13-UEV1A complex)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0061631"(ubiquitin conjugating enzyme activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070534"(protein K63-linked ubiquitination)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|interpro:IPR023313|rcsb pdb:1J7D|rcsb pdb:2C2V|rcsb pdb:3HCT|rcsb pdb:3HCU|rcsb pdb:3VON|rcsb pdb:3W31|rcsb pdb:4DHI|rcsb pdb:4DHJ|rcsb pdb:4DHZ|rcsb pdb:4IP3|rcsb pdb:4NR3|rcsb pdb:4NRG|rcsb pdb:4NRI|rcsb pdb:4ONL|rcsb pdb:4ONM|rcsb pdb:4ONN|rcsb pdb:4ORH|rcsb pdb:4TKP|rcsb pdb:4WHV|rcsb pdb:5AIT|rcsb pdb:5AIU|rcsb pdb:5EYA|rcsb pdb:5H7S|rcsb pdb:5VNZ|rcsb pdb:5VO0|rcsb pdb:5YWR|rcsb pdb:6D6I|rcsb pdb:6JKY|rcsb pdb:6KFP|rcsb pdb:6KG6|rcsb pdb:6KL4|rcsb pdb:6LP2|rcsb pdb:6P5B|rcsb pdb:6S53|reactome:R-HSA-168927|reactome:R-HSA-202424|reactome:R-HSA-2871837|reactome:R-HSA-445989|reactome:R-HSA-450302|reactome:R-HSA-450321|reactome:R-HSA-5607764|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-5696395|reactome:R-HSA-69473|reactome:R-HSA-8866654|reactome:R-HSA-9020702|reactome:R-HSA-937039|reactome:R-HSA-937041|reactome:R-HSA-9646399|reactome:R-HSA-975110|reactome:R-HSA-975144|reactome:R-HSA-983168|rcsb pdb:6ULH|rcsb pdb:6UMP|rcsb pdb:6UMS|rcsb pdb:7BBD|rcsb pdb:7BBF|rcsb pdb:7BXG|reactome:R-HSA-1169408|reactome:R-HSA-168638	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S2|caution:"UBE2N has been marked as the enzyme in this assay, although it is the UBE2N-UBE2V1 complex that has ubiquitinase (E3) activity. Neither UBE2N nor UBE2V1 have E2 or E3 activity on their own."|resulting-ptm:Q969K3 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:pvINlXbJ9UfZbyW4YqRO+HQsCnw9606	rogid:dqdszHlq5FLPHC6UWX6uvkC6Yz89606	intact-crc:54588D89143EFB78|rigid:Ki/tyFtfGz2BZOcP9T0Bk8/r2LA	false	-	his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q96A61	uniprotkb:Q13404	intact:EBI-2796931|intact:EBI-28986347|ensembl:ENSP00000483005|uniprotkb:L0CQ38|uniprotkb:Q59G66	intact:EBI-1050671|uniprotkb:Q13403|uniprotkb:Q13532|uniprotkb:Q96H34|uniprotkb:Q9GZT0|uniprotkb:Q9GZW1|uniprotkb:Q9H4J3|uniprotkb:Q9H4J4|uniprotkb:Q9UKL1|uniprotkb:Q9UM48|uniprotkb:Q9UM49|uniprotkb:Q9UM50|uniprotkb:Q5TGE3|uniprotkb:E1P629|uniprotkb:Q5TGE0|ensembl:ENSP00000360739	psi-mi:tri52_human(display_long)|uniprotkb:RNF102(gene name synonym)|uniprotkb:RING finger protein 102(gene name synonym)|uniprotkb:Tripartite motif-containing protein 52(gene name synonym)|uniprotkb:TRIM52(gene name)|psi-mi:TRIM52(display_short)	psi-mi:ub2v1_human(display_long)|uniprotkb:CROC-1(gene name synonym)|uniprotkb:TRAF6-regulated IKK activator 1 beta Uev1A(gene name synonym)|uniprotkb:P/OKcl.19(orf name)|uniprotkb:UBE2V1(gene name)|psi-mi:UBE2V1(display_short)|uniprotkb:CROC1(gene name synonym)|uniprotkb:UBE2V(gene name synonym)|uniprotkb:UEV1(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9970937|imex:IM-22822-49	author-confidence:Z-score = 3.85	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_116154.1|ensembl:ENSP00000483005|ensembl:ENSG00000183718(gene)|ensembl:ENST00000611618(transcript)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016604"(nuclear body)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051607"(defense response to virus)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0061630"(ubiquitin protein ligase activity)|interpro:IPR000315(Zinc finger, B-box)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907	refseq:NP_001027459.1|refseq:NP_068823.2|refseq:NP_071887.1|refseq:NP_954595.1|refseq:NP_954673.1|refseq:NP_001244322.1|refseq:NP_001244323.1|refseq:NP_001244325.1|ensembl:ENSG00000244687(gene)|ensembl:ENST00000371674(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006282"(regulation of DNA repair)|go:"GO:0006301"(postreplication repair)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0030154"(cell differentiation)|go:"GO:0031371"(ubiquitin conjugating enzyme complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035370"(UBC13-UEV1A complex)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070534"(protein K63-linked ubiquitination)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|rcsb pdb:2A4D|rcsb pdb:2C2V|rcsb pdb:2HLW|rcsb pdb:6D6I|reactome:R-HSA-168638|reactome:R-HSA-168927|reactome:R-HSA-202424|reactome:R-HSA-2871837|reactome:R-HSA-445989|reactome:R-HSA-450302|reactome:R-HSA-450321|reactome:R-HSA-5607764|reactome:R-HSA-9020702|reactome:R-HSA-937039|reactome:R-HSA-937041|reactome:R-HSA-9646399|reactome:R-HSA-975110|reactome:R-HSA-975144|reactome:R-HSA-983168|dip:DIP-41911N	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S2|caution:"UBE2N has been marked as the enzyme in this assay, although it is the UBE2N-UBE2V1 complex that has ubiquitinase (E3) activity. Neither UBE2N nor UBE2V1 have E2 or E3 activity on their own."|resulting-ptm:Q96A61 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:AbWXJoQ5nmwZcjYt3M+E4Emv8rE9606	rogid:x95N7Dj2KIqu5gySX59xLmfthUg9606	intact-crc:26733C1FA9B4F917|rigid:b15Ngd92W3cyUOjhVE12LY7h/iA	false	-	his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q96A61	uniprotkb:P22314	intact:EBI-2796931|intact:EBI-28986347|ensembl:ENSP00000483005|uniprotkb:L0CQ38|uniprotkb:Q59G66	intact:EBI-709688|uniprotkb:Q96E13|uniprotkb:Q5JRR8|ensembl:ENSP00000338413|ensembl:ENSP00000366568	psi-mi:tri52_human(display_long)|uniprotkb:RNF102(gene name synonym)|uniprotkb:RING finger protein 102(gene name synonym)|uniprotkb:Tripartite motif-containing protein 52(gene name synonym)|uniprotkb:TRIM52(gene name)|psi-mi:TRIM52(display_short)	psi-mi:uba1_human(display_long)|uniprotkb:Ubiquitin-activating enzyme E1(gene name synonym)|uniprotkb:Protein A1S9(gene name synonym)|uniprotkb:UBA1(gene name)|psi-mi:UBA1(display_short)|uniprotkb:A1S9T(gene name synonym)|uniprotkb:UBE1(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9970937|imex:IM-22822-49	author-confidence:Z-score = 3.85	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_116154.1|ensembl:ENSP00000483005|ensembl:ENSG00000183718(gene)|ensembl:ENST00000611618(transcript)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016604"(nuclear body)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051607"(defense response to virus)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0061630"(ubiquitin protein ligase activity)|interpro:IPR000315(Zinc finger, B-box)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907	refseq:NP_003325.2|refseq:NP_695012.1|refseq:XP_016885269.1|refseq:XP_016885270.1|dip:DIP-33686N|ensembl:ENSG00000130985(gene)|ensembl:ENST00000335972(transcript)|ensembl:ENST00000377351(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0004839"(ubiquitin activating enzyme activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0032446"(protein modification by small protein conjugation)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000011(Ubiquitin-activating enzyme, E1)|interpro:IPR000594(UBA/THIF-type NAD/FAD binding fold)|interpro:IPR018074|interpro:IPR018075|interpro:IPR018965|interpro:IPR019572|interpro:IPR032418|interpro:IPR032420|interpro:IPR033127|interpro:IPR035985|interpro:IPR038252|interpro:IPR042063|interpro:IPR042302|interpro:IPR042449|mint:P22314|rcsb pdb:4P22|rcsb pdb:6DC6|reactome:R-HSA-8866652|reactome:R-HSA-983168	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S2|caution:"UBE2N has been marked as the enzyme in this assay, although it is the UBE2N-UBE2V1 complex that has ubiquitinase (E3) activity. Neither UBE2N nor UBE2V1 have E2 or E3 activity on their own."|resulting-ptm:Q96A61 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:AbWXJoQ5nmwZcjYt3M+E4Emv8rE9606	rogid:q+vEeA0XLST0Zz173bmEt0dNbDE9606	intact-crc:26733C1FA9B4F917|rigid:b15Ngd92W3cyUOjhVE12LY7h/iA	false	-	his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q96A61	uniprotkb:P61088	intact:EBI-2796931|intact:EBI-28986347|ensembl:ENSP00000483005|uniprotkb:L0CQ38|uniprotkb:Q59G66	intact:EBI-1052908|uniprotkb:Q16781|uniprotkb:Q53Y81|ensembl:ENSP00000316176	psi-mi:tri52_human(display_long)|uniprotkb:RNF102(gene name synonym)|uniprotkb:RING finger protein 102(gene name synonym)|uniprotkb:Tripartite motif-containing protein 52(gene name synonym)|uniprotkb:TRIM52(gene name)|psi-mi:TRIM52(display_short)	psi-mi:ube2n_human(display_long)|uniprotkb:Ubiquitin-protein ligase N(gene name synonym)|uniprotkb:Ubiquitin carrier protein N(gene name synonym)|uniprotkb:Ubc13(gene name synonym)|uniprotkb:Bendless-like ubiquitin-conjugating enzyme(gene name synonym)|uniprotkb:UBE2N(gene name)|psi-mi:UBE2N(display_short)|uniprotkb:BLU(gene name synonym)|uniprotkb:UbcH13(gene name synonym)|uniprotkb:E2 ubiquitin-conjugating enzyme N(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9970937|imex:IM-22822-49	author-confidence:Z-score = 3.85	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_116154.1|ensembl:ENSP00000483005|ensembl:ENSG00000183718(gene)|ensembl:ENST00000611618(transcript)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016604"(nuclear body)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051607"(defense response to virus)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0061630"(ubiquitin protein ligase activity)|interpro:IPR000315(Zinc finger, B-box)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907	refseq:NP_003339.1|dip:DIP-29829N|ensembl:ENSG00000177889(gene)|ensembl:ENST00000318066(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000729"(DNA double-strand break processing)|go:"GO:0001650"(fibrillar center)|go:"GO:0003723"(RNA binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006282"(regulation of DNA repair)|go:"GO:0006301"(postreplication repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016574"(histone ubiquitination)|go:"GO:0031058"(positive regulation of histone modification)|go:"GO:0031372"(UBC13-MMS2 complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033182"(regulation of histone ubiquitination)|go:"GO:0035370"(UBC13-UEV1A complex)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0061631"(ubiquitin conjugating enzyme activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070534"(protein K63-linked ubiquitination)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|interpro:IPR023313|rcsb pdb:1J7D|rcsb pdb:2C2V|rcsb pdb:3HCT|rcsb pdb:3HCU|rcsb pdb:3VON|rcsb pdb:3W31|rcsb pdb:4DHI|rcsb pdb:4DHJ|rcsb pdb:4DHZ|rcsb pdb:4IP3|rcsb pdb:4NR3|rcsb pdb:4NRG|rcsb pdb:4NRI|rcsb pdb:4ONL|rcsb pdb:4ONM|rcsb pdb:4ONN|rcsb pdb:4ORH|rcsb pdb:4TKP|rcsb pdb:4WHV|rcsb pdb:5AIT|rcsb pdb:5AIU|rcsb pdb:5EYA|rcsb pdb:5H7S|rcsb pdb:5VNZ|rcsb pdb:5VO0|rcsb pdb:5YWR|rcsb pdb:6D6I|rcsb pdb:6JKY|rcsb pdb:6KFP|rcsb pdb:6KG6|rcsb pdb:6KL4|rcsb pdb:6LP2|rcsb pdb:6P5B|rcsb pdb:6S53|reactome:R-HSA-168927|reactome:R-HSA-202424|reactome:R-HSA-2871837|reactome:R-HSA-445989|reactome:R-HSA-450302|reactome:R-HSA-450321|reactome:R-HSA-5607764|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-5696395|reactome:R-HSA-69473|reactome:R-HSA-8866654|reactome:R-HSA-9020702|reactome:R-HSA-937039|reactome:R-HSA-937041|reactome:R-HSA-9646399|reactome:R-HSA-975110|reactome:R-HSA-975144|reactome:R-HSA-983168|rcsb pdb:6ULH|rcsb pdb:6UMP|rcsb pdb:6UMS|rcsb pdb:7BBD|rcsb pdb:7BBF|rcsb pdb:7BXG|reactome:R-HSA-1169408|reactome:R-HSA-168638	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S2|caution:"UBE2N has been marked as the enzyme in this assay, although it is the UBE2N-UBE2V1 complex that has ubiquitinase (E3) activity. Neither UBE2N nor UBE2V1 have E2 or E3 activity on their own."|resulting-ptm:Q96A61 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:AbWXJoQ5nmwZcjYt3M+E4Emv8rE9606	rogid:dqdszHlq5FLPHC6UWX6uvkC6Yz89606	intact-crc:26733C1FA9B4F917|rigid:b15Ngd92W3cyUOjhVE12LY7h/iA	false	-	his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q96CA5	uniprotkb:Q13404	intact:EBI-517623|uniprotkb:Q9BQV0|uniprotkb:Q9H2A8|uniprotkb:Q9HAP7|ensembl:ENSP00000217169	intact:EBI-1050671|uniprotkb:Q13403|uniprotkb:Q13532|uniprotkb:Q96H34|uniprotkb:Q9GZT0|uniprotkb:Q9GZW1|uniprotkb:Q9H4J3|uniprotkb:Q9H4J4|uniprotkb:Q9UKL1|uniprotkb:Q9UM48|uniprotkb:Q9UM49|uniprotkb:Q9UM50|uniprotkb:Q5TGE3|uniprotkb:E1P629|uniprotkb:Q5TGE0|ensembl:ENSP00000360739	psi-mi:birc7_human(display_long)|uniprotkb:Kidney inhibitor of apoptosis protein(gene name synonym)|uniprotkb:Melanoma inhibitor of apoptosis protein(gene name synonym)|uniprotkb:Livin(gene name synonym)|uniprotkb:RING finger protein 50(gene name synonym)|uniprotkb:UNQ5800/PRO19607/PRO21344(orf name)|uniprotkb:BIRC7(gene name)|psi-mi:BIRC7(display_short)|uniprotkb:KIAP(gene name synonym)|uniprotkb:LIVIN(gene name synonym)|uniprotkb:MLIAP(gene name synonym)|uniprotkb:RNF50(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase BIRC7(gene name synonym)	psi-mi:ub2v1_human(display_long)|uniprotkb:CROC-1(gene name synonym)|uniprotkb:TRAF6-regulated IKK activator 1 beta Uev1A(gene name synonym)|uniprotkb:P/OKcl.19(orf name)|uniprotkb:UBE2V1(gene name)|psi-mi:UBE2V1(display_short)|uniprotkb:CROC1(gene name synonym)|uniprotkb:UBE2V(gene name synonym)|uniprotkb:UEV1(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9970958|imex:IM-22822-50	author-confidence:Z-score = 18.66|author-confidence:Z-score = 18.67	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_071444.1|refseq:NP_647478.1|dip:DIP-33486N|ensembl:ENSG00000101197(gene)|ensembl:ENST00000217169(transcript)|go:"GO:0002088"(lens development in camera-type eye)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0004869"(cysteine-type endopeptidase inhibitor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019899"(enzyme binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0043027"(cysteine-type endopeptidase inhibitor activity involved in apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070247"(regulation of natural killer cell apoptotic process)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR001370(Proteinase inhibitor I32, inhibitor of apoptosis)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|rcsb pdb:1OXN|rcsb pdb:1OXQ|rcsb pdb:1OY7|rcsb pdb:1TW6|rcsb pdb:2I3H|rcsb pdb:2I3I|rcsb pdb:3F7G|rcsb pdb:3F7H|rcsb pdb:3F7I|rcsb pdb:3GT9|rcsb pdb:3GTA|rcsb pdb:3UW5|rcsb pdb:4AUQ	refseq:NP_001027459.1|refseq:NP_068823.2|refseq:NP_071887.1|refseq:NP_954595.1|refseq:NP_954673.1|refseq:NP_001244322.1|refseq:NP_001244323.1|refseq:NP_001244325.1|ensembl:ENSG00000244687(gene)|ensembl:ENST00000371674(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006282"(regulation of DNA repair)|go:"GO:0006301"(postreplication repair)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0030154"(cell differentiation)|go:"GO:0031371"(ubiquitin conjugating enzyme complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035370"(UBC13-UEV1A complex)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070534"(protein K63-linked ubiquitination)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|rcsb pdb:2A4D|rcsb pdb:2C2V|rcsb pdb:2HLW|rcsb pdb:6D6I|reactome:R-HSA-168638|reactome:R-HSA-168927|reactome:R-HSA-202424|reactome:R-HSA-2871837|reactome:R-HSA-445989|reactome:R-HSA-450302|reactome:R-HSA-450321|reactome:R-HSA-5607764|reactome:R-HSA-9020702|reactome:R-HSA-937039|reactome:R-HSA-937041|reactome:R-HSA-9646399|reactome:R-HSA-975110|reactome:R-HSA-975144|reactome:R-HSA-983168|dip:DIP-41911N	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S2|caution:"UBE2N has been marked as the enzyme in this assay, although it is the UBE2N-UBE2V1 complex that has ubiquitinase (E3) activity. Neither UBE2N nor UBE2V1 have E2 or E3 activity on their own."|resulting-ptm:Q96CA5 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:hXh11nqcUM5IFQL3tS2/czb4lyA9606	rogid:x95N7Dj2KIqu5gySX59xLmfthUg9606	intact-crc:0031FD204611B22D|rigid:QIzNJ6aJchmwBEMxAgOsJ/KbRyE	false	-	his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q96CA5	uniprotkb:P22314	intact:EBI-517623|uniprotkb:Q9BQV0|uniprotkb:Q9H2A8|uniprotkb:Q9HAP7|ensembl:ENSP00000217169	intact:EBI-709688|uniprotkb:Q96E13|uniprotkb:Q5JRR8|ensembl:ENSP00000338413|ensembl:ENSP00000366568	psi-mi:birc7_human(display_long)|uniprotkb:Kidney inhibitor of apoptosis protein(gene name synonym)|uniprotkb:Melanoma inhibitor of apoptosis protein(gene name synonym)|uniprotkb:Livin(gene name synonym)|uniprotkb:RING finger protein 50(gene name synonym)|uniprotkb:UNQ5800/PRO19607/PRO21344(orf name)|uniprotkb:BIRC7(gene name)|psi-mi:BIRC7(display_short)|uniprotkb:KIAP(gene name synonym)|uniprotkb:LIVIN(gene name synonym)|uniprotkb:MLIAP(gene name synonym)|uniprotkb:RNF50(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase BIRC7(gene name synonym)	psi-mi:uba1_human(display_long)|uniprotkb:Ubiquitin-activating enzyme E1(gene name synonym)|uniprotkb:Protein A1S9(gene name synonym)|uniprotkb:UBA1(gene name)|psi-mi:UBA1(display_short)|uniprotkb:A1S9T(gene name synonym)|uniprotkb:UBE1(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9970958|imex:IM-22822-50	author-confidence:Z-score = 18.66|author-confidence:Z-score = 18.67	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_071444.1|refseq:NP_647478.1|dip:DIP-33486N|ensembl:ENSG00000101197(gene)|ensembl:ENST00000217169(transcript)|go:"GO:0002088"(lens development in camera-type eye)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0004869"(cysteine-type endopeptidase inhibitor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019899"(enzyme binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0043027"(cysteine-type endopeptidase inhibitor activity involved in apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070247"(regulation of natural killer cell apoptotic process)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR001370(Proteinase inhibitor I32, inhibitor of apoptosis)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|rcsb pdb:1OXN|rcsb pdb:1OXQ|rcsb pdb:1OY7|rcsb pdb:1TW6|rcsb pdb:2I3H|rcsb pdb:2I3I|rcsb pdb:3F7G|rcsb pdb:3F7H|rcsb pdb:3F7I|rcsb pdb:3GT9|rcsb pdb:3GTA|rcsb pdb:3UW5|rcsb pdb:4AUQ	refseq:NP_003325.2|refseq:NP_695012.1|refseq:XP_016885269.1|refseq:XP_016885270.1|dip:DIP-33686N|ensembl:ENSG00000130985(gene)|ensembl:ENST00000335972(transcript)|ensembl:ENST00000377351(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0004839"(ubiquitin activating enzyme activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0032446"(protein modification by small protein conjugation)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000011(Ubiquitin-activating enzyme, E1)|interpro:IPR000594(UBA/THIF-type NAD/FAD binding fold)|interpro:IPR018074|interpro:IPR018075|interpro:IPR018965|interpro:IPR019572|interpro:IPR032418|interpro:IPR032420|interpro:IPR033127|interpro:IPR035985|interpro:IPR038252|interpro:IPR042063|interpro:IPR042302|interpro:IPR042449|mint:P22314|rcsb pdb:4P22|rcsb pdb:6DC6|reactome:R-HSA-8866652|reactome:R-HSA-983168	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S2|caution:"UBE2N has been marked as the enzyme in this assay, although it is the UBE2N-UBE2V1 complex that has ubiquitinase (E3) activity. Neither UBE2N nor UBE2V1 have E2 or E3 activity on their own."|resulting-ptm:Q96CA5 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:hXh11nqcUM5IFQL3tS2/czb4lyA9606	rogid:q+vEeA0XLST0Zz173bmEt0dNbDE9606	intact-crc:0031FD204611B22D|rigid:QIzNJ6aJchmwBEMxAgOsJ/KbRyE	false	-	his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q96CA5	uniprotkb:P61088	intact:EBI-517623|uniprotkb:Q9BQV0|uniprotkb:Q9H2A8|uniprotkb:Q9HAP7|ensembl:ENSP00000217169	intact:EBI-1052908|uniprotkb:Q16781|uniprotkb:Q53Y81|ensembl:ENSP00000316176	psi-mi:birc7_human(display_long)|uniprotkb:Kidney inhibitor of apoptosis protein(gene name synonym)|uniprotkb:Melanoma inhibitor of apoptosis protein(gene name synonym)|uniprotkb:Livin(gene name synonym)|uniprotkb:RING finger protein 50(gene name synonym)|uniprotkb:UNQ5800/PRO19607/PRO21344(orf name)|uniprotkb:BIRC7(gene name)|psi-mi:BIRC7(display_short)|uniprotkb:KIAP(gene name synonym)|uniprotkb:LIVIN(gene name synonym)|uniprotkb:MLIAP(gene name synonym)|uniprotkb:RNF50(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase BIRC7(gene name synonym)	psi-mi:ube2n_human(display_long)|uniprotkb:Ubiquitin-protein ligase N(gene name synonym)|uniprotkb:Ubiquitin carrier protein N(gene name synonym)|uniprotkb:Ubc13(gene name synonym)|uniprotkb:Bendless-like ubiquitin-conjugating enzyme(gene name synonym)|uniprotkb:UBE2N(gene name)|psi-mi:UBE2N(display_short)|uniprotkb:BLU(gene name synonym)|uniprotkb:UbcH13(gene name synonym)|uniprotkb:E2 ubiquitin-conjugating enzyme N(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9970958|imex:IM-22822-50	author-confidence:Z-score = 18.66|author-confidence:Z-score = 18.67	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_071444.1|refseq:NP_647478.1|dip:DIP-33486N|ensembl:ENSG00000101197(gene)|ensembl:ENST00000217169(transcript)|go:"GO:0002088"(lens development in camera-type eye)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0004869"(cysteine-type endopeptidase inhibitor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019899"(enzyme binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0043027"(cysteine-type endopeptidase inhibitor activity involved in apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070247"(regulation of natural killer cell apoptotic process)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR001370(Proteinase inhibitor I32, inhibitor of apoptosis)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|rcsb pdb:1OXN|rcsb pdb:1OXQ|rcsb pdb:1OY7|rcsb pdb:1TW6|rcsb pdb:2I3H|rcsb pdb:2I3I|rcsb pdb:3F7G|rcsb pdb:3F7H|rcsb pdb:3F7I|rcsb pdb:3GT9|rcsb pdb:3GTA|rcsb pdb:3UW5|rcsb pdb:4AUQ	refseq:NP_003339.1|dip:DIP-29829N|ensembl:ENSG00000177889(gene)|ensembl:ENST00000318066(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000729"(DNA double-strand break processing)|go:"GO:0001650"(fibrillar center)|go:"GO:0003723"(RNA binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006282"(regulation of DNA repair)|go:"GO:0006301"(postreplication repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016574"(histone ubiquitination)|go:"GO:0031058"(positive regulation of histone modification)|go:"GO:0031372"(UBC13-MMS2 complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033182"(regulation of histone ubiquitination)|go:"GO:0035370"(UBC13-UEV1A complex)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0061631"(ubiquitin conjugating enzyme activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070534"(protein K63-linked ubiquitination)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|interpro:IPR023313|rcsb pdb:1J7D|rcsb pdb:2C2V|rcsb pdb:3HCT|rcsb pdb:3HCU|rcsb pdb:3VON|rcsb pdb:3W31|rcsb pdb:4DHI|rcsb pdb:4DHJ|rcsb pdb:4DHZ|rcsb pdb:4IP3|rcsb pdb:4NR3|rcsb pdb:4NRG|rcsb pdb:4NRI|rcsb pdb:4ONL|rcsb pdb:4ONM|rcsb pdb:4ONN|rcsb pdb:4ORH|rcsb pdb:4TKP|rcsb pdb:4WHV|rcsb pdb:5AIT|rcsb pdb:5AIU|rcsb pdb:5EYA|rcsb pdb:5H7S|rcsb pdb:5VNZ|rcsb pdb:5VO0|rcsb pdb:5YWR|rcsb pdb:6D6I|rcsb pdb:6JKY|rcsb pdb:6KFP|rcsb pdb:6KG6|rcsb pdb:6KL4|rcsb pdb:6LP2|rcsb pdb:6P5B|rcsb pdb:6S53|reactome:R-HSA-168927|reactome:R-HSA-202424|reactome:R-HSA-2871837|reactome:R-HSA-445989|reactome:R-HSA-450302|reactome:R-HSA-450321|reactome:R-HSA-5607764|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-5696395|reactome:R-HSA-69473|reactome:R-HSA-8866654|reactome:R-HSA-9020702|reactome:R-HSA-937039|reactome:R-HSA-937041|reactome:R-HSA-9646399|reactome:R-HSA-975110|reactome:R-HSA-975144|reactome:R-HSA-983168|rcsb pdb:6ULH|rcsb pdb:6UMP|rcsb pdb:6UMS|rcsb pdb:7BBD|rcsb pdb:7BBF|rcsb pdb:7BXG|reactome:R-HSA-1169408|reactome:R-HSA-168638	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S2|caution:"UBE2N has been marked as the enzyme in this assay, although it is the UBE2N-UBE2V1 complex that has ubiquitinase (E3) activity. Neither UBE2N nor UBE2V1 have E2 or E3 activity on their own."|resulting-ptm:Q96CA5 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:hXh11nqcUM5IFQL3tS2/czb4lyA9606	rogid:dqdszHlq5FLPHC6UWX6uvkC6Yz89606	intact-crc:0031FD204611B22D|rigid:QIzNJ6aJchmwBEMxAgOsJ/KbRyE	false	-	his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q96F44	uniprotkb:Q13404	intact:EBI-851809|uniprotkb:B2RB82|uniprotkb:B3KUS3|uniprotkb:B4DX88|uniprotkb:Q8NCA6|uniprotkb:Q9C022|uniprotkb:A6NKE2|uniprotkb:Q5VSU1|ensembl:ENSP00000284551	intact:EBI-1050671|uniprotkb:Q13403|uniprotkb:Q13532|uniprotkb:Q96H34|uniprotkb:Q9GZT0|uniprotkb:Q9GZW1|uniprotkb:Q9H4J3|uniprotkb:Q9H4J4|uniprotkb:Q9UKL1|uniprotkb:Q9UM48|uniprotkb:Q9UM49|uniprotkb:Q9UM50|uniprotkb:Q5TGE3|uniprotkb:E1P629|uniprotkb:Q5TGE0|ensembl:ENSP00000360739	psi-mi:tri11_human(display_long)|uniprotkb:RING finger protein 92(gene name synonym)|uniprotkb:Protein BIA1(gene name synonym)|uniprotkb:TRIM11(gene name)|psi-mi:TRIM11(display_short)|uniprotkb:RNF92(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase TRIM11(gene name synonym)|uniprotkb:Tripartite motif-containing protein 11(gene name synonym)	psi-mi:ub2v1_human(display_long)|uniprotkb:CROC-1(gene name synonym)|uniprotkb:TRAF6-regulated IKK activator 1 beta Uev1A(gene name synonym)|uniprotkb:P/OKcl.19(orf name)|uniprotkb:UBE2V1(gene name)|psi-mi:UBE2V1(display_short)|uniprotkb:CROC1(gene name synonym)|uniprotkb:UBE2V(gene name synonym)|uniprotkb:UEV1(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9970980|imex:IM-22822-51	author-confidence:Z-score = 18.68	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_660215.1|refseq:XP_016857901.1|ensembl:ENSG00000154370(gene)|ensembl:ENST00000284551(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0032897"(negative regulation of viral transcription)|go:"GO:0045087"(innate immune response)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046597"(negative regulation of viral entry into host cell)|go:"GO:0046598"(positive regulation of viral entry into host cell)|go:"GO:0050768"(negative regulation of neurogenesis)|go:"GO:0051607"(defense response to virus)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:1902187"|interpro:IPR000315(Zinc finger, B-box)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR001870("B302 (SPRY)-like")|interpro:IPR003877(SPla/RYanodine receptor SPRY)|interpro:IPR003879(Butyrophylin-like)|interpro:IPR006574(SPRY-associated)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR017907|interpro:IPR043136|mint:Q96F44|reactome:R-HSA-983168	refseq:NP_001027459.1|refseq:NP_068823.2|refseq:NP_071887.1|refseq:NP_954595.1|refseq:NP_954673.1|refseq:NP_001244322.1|refseq:NP_001244323.1|refseq:NP_001244325.1|ensembl:ENSG00000244687(gene)|ensembl:ENST00000371674(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006282"(regulation of DNA repair)|go:"GO:0006301"(postreplication repair)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0030154"(cell differentiation)|go:"GO:0031371"(ubiquitin conjugating enzyme complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035370"(UBC13-UEV1A complex)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070534"(protein K63-linked ubiquitination)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|rcsb pdb:2A4D|rcsb pdb:2C2V|rcsb pdb:2HLW|rcsb pdb:6D6I|reactome:R-HSA-168638|reactome:R-HSA-168927|reactome:R-HSA-202424|reactome:R-HSA-2871837|reactome:R-HSA-445989|reactome:R-HSA-450302|reactome:R-HSA-450321|reactome:R-HSA-5607764|reactome:R-HSA-9020702|reactome:R-HSA-937039|reactome:R-HSA-937041|reactome:R-HSA-9646399|reactome:R-HSA-975110|reactome:R-HSA-975144|reactome:R-HSA-983168|dip:DIP-41911N	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S2|caution:"UBE2N has been marked as the enzyme in this assay, although it is the UBE2N-UBE2V1 complex that has ubiquitinase (E3) activity. Neither UBE2N nor UBE2V1 have E2 or E3 activity on their own."|resulting-ptm:Q96F44 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:cE4Lcnp0zSSEpo3e9Kr940Vdit89606	rogid:x95N7Dj2KIqu5gySX59xLmfthUg9606	intact-crc:56B1547CF548F234|rigid:09y1LMymAyt//spqBfI/yHwI7ks	false	-	his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q96F44	uniprotkb:P22314	intact:EBI-851809|uniprotkb:B2RB82|uniprotkb:B3KUS3|uniprotkb:B4DX88|uniprotkb:Q8NCA6|uniprotkb:Q9C022|uniprotkb:A6NKE2|uniprotkb:Q5VSU1|ensembl:ENSP00000284551	intact:EBI-709688|uniprotkb:Q96E13|uniprotkb:Q5JRR8|ensembl:ENSP00000338413|ensembl:ENSP00000366568	psi-mi:tri11_human(display_long)|uniprotkb:RING finger protein 92(gene name synonym)|uniprotkb:Protein BIA1(gene name synonym)|uniprotkb:TRIM11(gene name)|psi-mi:TRIM11(display_short)|uniprotkb:RNF92(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase TRIM11(gene name synonym)|uniprotkb:Tripartite motif-containing protein 11(gene name synonym)	psi-mi:uba1_human(display_long)|uniprotkb:Ubiquitin-activating enzyme E1(gene name synonym)|uniprotkb:Protein A1S9(gene name synonym)|uniprotkb:UBA1(gene name)|psi-mi:UBA1(display_short)|uniprotkb:A1S9T(gene name synonym)|uniprotkb:UBE1(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9970980|imex:IM-22822-51	author-confidence:Z-score = 18.68	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_660215.1|refseq:XP_016857901.1|ensembl:ENSG00000154370(gene)|ensembl:ENST00000284551(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0032897"(negative regulation of viral transcription)|go:"GO:0045087"(innate immune response)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046597"(negative regulation of viral entry into host cell)|go:"GO:0046598"(positive regulation of viral entry into host cell)|go:"GO:0050768"(negative regulation of neurogenesis)|go:"GO:0051607"(defense response to virus)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:1902187"|interpro:IPR000315(Zinc finger, B-box)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR001870("B302 (SPRY)-like")|interpro:IPR003877(SPla/RYanodine receptor SPRY)|interpro:IPR003879(Butyrophylin-like)|interpro:IPR006574(SPRY-associated)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR017907|interpro:IPR043136|mint:Q96F44|reactome:R-HSA-983168	refseq:NP_003325.2|refseq:NP_695012.1|refseq:XP_016885269.1|refseq:XP_016885270.1|dip:DIP-33686N|ensembl:ENSG00000130985(gene)|ensembl:ENST00000335972(transcript)|ensembl:ENST00000377351(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0004839"(ubiquitin activating enzyme activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0032446"(protein modification by small protein conjugation)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000011(Ubiquitin-activating enzyme, E1)|interpro:IPR000594(UBA/THIF-type NAD/FAD binding fold)|interpro:IPR018074|interpro:IPR018075|interpro:IPR018965|interpro:IPR019572|interpro:IPR032418|interpro:IPR032420|interpro:IPR033127|interpro:IPR035985|interpro:IPR038252|interpro:IPR042063|interpro:IPR042302|interpro:IPR042449|mint:P22314|rcsb pdb:4P22|rcsb pdb:6DC6|reactome:R-HSA-8866652|reactome:R-HSA-983168	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S2|caution:"UBE2N has been marked as the enzyme in this assay, although it is the UBE2N-UBE2V1 complex that has ubiquitinase (E3) activity. Neither UBE2N nor UBE2V1 have E2 or E3 activity on their own."|resulting-ptm:Q96F44 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:cE4Lcnp0zSSEpo3e9Kr940Vdit89606	rogid:q+vEeA0XLST0Zz173bmEt0dNbDE9606	intact-crc:56B1547CF548F234|rigid:09y1LMymAyt//spqBfI/yHwI7ks	false	-	his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q96F44	uniprotkb:P61088	intact:EBI-851809|uniprotkb:B2RB82|uniprotkb:B3KUS3|uniprotkb:B4DX88|uniprotkb:Q8NCA6|uniprotkb:Q9C022|uniprotkb:A6NKE2|uniprotkb:Q5VSU1|ensembl:ENSP00000284551	intact:EBI-1052908|uniprotkb:Q16781|uniprotkb:Q53Y81|ensembl:ENSP00000316176	psi-mi:tri11_human(display_long)|uniprotkb:RING finger protein 92(gene name synonym)|uniprotkb:Protein BIA1(gene name synonym)|uniprotkb:TRIM11(gene name)|psi-mi:TRIM11(display_short)|uniprotkb:RNF92(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase TRIM11(gene name synonym)|uniprotkb:Tripartite motif-containing protein 11(gene name synonym)	psi-mi:ube2n_human(display_long)|uniprotkb:Ubiquitin-protein ligase N(gene name synonym)|uniprotkb:Ubiquitin carrier protein N(gene name synonym)|uniprotkb:Ubc13(gene name synonym)|uniprotkb:Bendless-like ubiquitin-conjugating enzyme(gene name synonym)|uniprotkb:UBE2N(gene name)|psi-mi:UBE2N(display_short)|uniprotkb:BLU(gene name synonym)|uniprotkb:UbcH13(gene name synonym)|uniprotkb:E2 ubiquitin-conjugating enzyme N(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9970980|imex:IM-22822-51	author-confidence:Z-score = 18.68	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_660215.1|refseq:XP_016857901.1|ensembl:ENSG00000154370(gene)|ensembl:ENST00000284551(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0032897"(negative regulation of viral transcription)|go:"GO:0045087"(innate immune response)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046597"(negative regulation of viral entry into host cell)|go:"GO:0046598"(positive regulation of viral entry into host cell)|go:"GO:0050768"(negative regulation of neurogenesis)|go:"GO:0051607"(defense response to virus)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:1902187"|interpro:IPR000315(Zinc finger, B-box)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR001870("B302 (SPRY)-like")|interpro:IPR003877(SPla/RYanodine receptor SPRY)|interpro:IPR003879(Butyrophylin-like)|interpro:IPR006574(SPRY-associated)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR017907|interpro:IPR043136|mint:Q96F44|reactome:R-HSA-983168	refseq:NP_003339.1|dip:DIP-29829N|ensembl:ENSG00000177889(gene)|ensembl:ENST00000318066(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000729"(DNA double-strand break processing)|go:"GO:0001650"(fibrillar center)|go:"GO:0003723"(RNA binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006282"(regulation of DNA repair)|go:"GO:0006301"(postreplication repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016574"(histone ubiquitination)|go:"GO:0031058"(positive regulation of histone modification)|go:"GO:0031372"(UBC13-MMS2 complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033182"(regulation of histone ubiquitination)|go:"GO:0035370"(UBC13-UEV1A complex)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0061631"(ubiquitin conjugating enzyme activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070534"(protein K63-linked ubiquitination)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|interpro:IPR023313|rcsb pdb:1J7D|rcsb pdb:2C2V|rcsb pdb:3HCT|rcsb pdb:3HCU|rcsb pdb:3VON|rcsb pdb:3W31|rcsb pdb:4DHI|rcsb pdb:4DHJ|rcsb pdb:4DHZ|rcsb pdb:4IP3|rcsb pdb:4NR3|rcsb pdb:4NRG|rcsb pdb:4NRI|rcsb pdb:4ONL|rcsb pdb:4ONM|rcsb pdb:4ONN|rcsb pdb:4ORH|rcsb pdb:4TKP|rcsb pdb:4WHV|rcsb pdb:5AIT|rcsb pdb:5AIU|rcsb pdb:5EYA|rcsb pdb:5H7S|rcsb pdb:5VNZ|rcsb pdb:5VO0|rcsb pdb:5YWR|rcsb pdb:6D6I|rcsb pdb:6JKY|rcsb pdb:6KFP|rcsb pdb:6KG6|rcsb pdb:6KL4|rcsb pdb:6LP2|rcsb pdb:6P5B|rcsb pdb:6S53|reactome:R-HSA-168927|reactome:R-HSA-202424|reactome:R-HSA-2871837|reactome:R-HSA-445989|reactome:R-HSA-450302|reactome:R-HSA-450321|reactome:R-HSA-5607764|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-5696395|reactome:R-HSA-69473|reactome:R-HSA-8866654|reactome:R-HSA-9020702|reactome:R-HSA-937039|reactome:R-HSA-937041|reactome:R-HSA-9646399|reactome:R-HSA-975110|reactome:R-HSA-975144|reactome:R-HSA-983168|rcsb pdb:6ULH|rcsb pdb:6UMP|rcsb pdb:6UMS|rcsb pdb:7BBD|rcsb pdb:7BBF|rcsb pdb:7BXG|reactome:R-HSA-1169408|reactome:R-HSA-168638	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S2|caution:"UBE2N has been marked as the enzyme in this assay, although it is the UBE2N-UBE2V1 complex that has ubiquitinase (E3) activity. Neither UBE2N nor UBE2V1 have E2 or E3 activity on their own."|resulting-ptm:Q96F44 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:cE4Lcnp0zSSEpo3e9Kr940Vdit89606	rogid:dqdszHlq5FLPHC6UWX6uvkC6Yz89606	intact-crc:56B1547CF548F234|rigid:09y1LMymAyt//spqBfI/yHwI7ks	false	-	his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q96FA3	uniprotkb:Q13404	intact:EBI-448369|uniprotkb:Q96SM0|uniprotkb:Q9GZY5|uniprotkb:Q9HCX0|ensembl:ENSP00000351789	intact:EBI-1050671|uniprotkb:Q13403|uniprotkb:Q13532|uniprotkb:Q96H34|uniprotkb:Q9GZT0|uniprotkb:Q9GZW1|uniprotkb:Q9H4J3|uniprotkb:Q9H4J4|uniprotkb:Q9UKL1|uniprotkb:Q9UM48|uniprotkb:Q9UM49|uniprotkb:Q9UM50|uniprotkb:Q5TGE3|uniprotkb:E1P629|uniprotkb:Q5TGE0|ensembl:ENSP00000360739	psi-mi:peli1_human(display_long)|uniprotkb:Pellino-related intracellular-signaling molecule(gene name synonym)|uniprotkb:PELI1(gene name)|psi-mi:PELI1(display_short)|uniprotkb:PRISM(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase pellino homolog 1(gene name synonym)	psi-mi:ub2v1_human(display_long)|uniprotkb:CROC-1(gene name synonym)|uniprotkb:TRAF6-regulated IKK activator 1 beta Uev1A(gene name synonym)|uniprotkb:P/OKcl.19(orf name)|uniprotkb:UBE2V1(gene name)|psi-mi:UBE2V1(display_short)|uniprotkb:CROC1(gene name synonym)|uniprotkb:UBE2V(gene name synonym)|uniprotkb:UEV1(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9971001|imex:IM-22822-52	author-confidence:Z-score = 18.71	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_065702.2|refseq:XP_011531296.1|refseq:XP_016860009.1|dip:DIP-32488N|ensembl:ENSG00000197329(gene)|ensembl:ENST00000358912(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0008063"(Toll signaling pathway)|go:"GO:0008592"(regulation of Toll signaling pathway)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034141"(positive regulation of toll-like receptor 3 signaling pathway)|go:"GO:0034145"(positive regulation of toll-like receptor 4 signaling pathway)|go:"GO:0034450"(ubiquitin-ubiquitin ligase activity)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043331"(response to dsRNA)|go:"GO:0060544"(regulation of necroptotic process)|go:"GO:0060546"(negative regulation of necroptotic process)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0070936"(protein K48-linked ubiquitination)|interpro:IPR006800(Pellino)|mint:Q96FA3|reactome:R-HSA-5675482|reactome:R-HSA-9020702|reactome:R-HSA-937039|reactome:R-HSA-975144|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)	refseq:NP_001027459.1|refseq:NP_068823.2|refseq:NP_071887.1|refseq:NP_954595.1|refseq:NP_954673.1|refseq:NP_001244322.1|refseq:NP_001244323.1|refseq:NP_001244325.1|ensembl:ENSG00000244687(gene)|ensembl:ENST00000371674(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006282"(regulation of DNA repair)|go:"GO:0006301"(postreplication repair)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0030154"(cell differentiation)|go:"GO:0031371"(ubiquitin conjugating enzyme complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035370"(UBC13-UEV1A complex)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070534"(protein K63-linked ubiquitination)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|rcsb pdb:2A4D|rcsb pdb:2C2V|rcsb pdb:2HLW|rcsb pdb:6D6I|reactome:R-HSA-168638|reactome:R-HSA-168927|reactome:R-HSA-202424|reactome:R-HSA-2871837|reactome:R-HSA-445989|reactome:R-HSA-450302|reactome:R-HSA-450321|reactome:R-HSA-5607764|reactome:R-HSA-9020702|reactome:R-HSA-937039|reactome:R-HSA-937041|reactome:R-HSA-9646399|reactome:R-HSA-975110|reactome:R-HSA-975144|reactome:R-HSA-983168|dip:DIP-41911N	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S2|caution:"UBE2N has been marked as the enzyme in this assay, although it is the UBE2N-UBE2V1 complex that has ubiquitinase (E3) activity. Neither UBE2N nor UBE2V1 have E2 or E3 activity on their own."|resulting-ptm:Q96FA3 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:GbzrXWXiw4Kv/zN4kEscEKPkEXQ9606	rogid:x95N7Dj2KIqu5gySX59xLmfthUg9606	intact-crc:104734CF661979CF|rigid:7/fpP8wVrJ88Fx3e7N86U605hkg	false	-	his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q96FA3	uniprotkb:P22314	intact:EBI-448369|uniprotkb:Q96SM0|uniprotkb:Q9GZY5|uniprotkb:Q9HCX0|ensembl:ENSP00000351789	intact:EBI-709688|uniprotkb:Q96E13|uniprotkb:Q5JRR8|ensembl:ENSP00000338413|ensembl:ENSP00000366568	psi-mi:peli1_human(display_long)|uniprotkb:Pellino-related intracellular-signaling molecule(gene name synonym)|uniprotkb:PELI1(gene name)|psi-mi:PELI1(display_short)|uniprotkb:PRISM(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase pellino homolog 1(gene name synonym)	psi-mi:uba1_human(display_long)|uniprotkb:Ubiquitin-activating enzyme E1(gene name synonym)|uniprotkb:Protein A1S9(gene name synonym)|uniprotkb:UBA1(gene name)|psi-mi:UBA1(display_short)|uniprotkb:A1S9T(gene name synonym)|uniprotkb:UBE1(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9971001|imex:IM-22822-52	author-confidence:Z-score = 18.71	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_065702.2|refseq:XP_011531296.1|refseq:XP_016860009.1|dip:DIP-32488N|ensembl:ENSG00000197329(gene)|ensembl:ENST00000358912(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0008063"(Toll signaling pathway)|go:"GO:0008592"(regulation of Toll signaling pathway)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034141"(positive regulation of toll-like receptor 3 signaling pathway)|go:"GO:0034145"(positive regulation of toll-like receptor 4 signaling pathway)|go:"GO:0034450"(ubiquitin-ubiquitin ligase activity)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043331"(response to dsRNA)|go:"GO:0060544"(regulation of necroptotic process)|go:"GO:0060546"(negative regulation of necroptotic process)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0070936"(protein K48-linked ubiquitination)|interpro:IPR006800(Pellino)|mint:Q96FA3|reactome:R-HSA-5675482|reactome:R-HSA-9020702|reactome:R-HSA-937039|reactome:R-HSA-975144|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)	refseq:NP_003325.2|refseq:NP_695012.1|refseq:XP_016885269.1|refseq:XP_016885270.1|dip:DIP-33686N|ensembl:ENSG00000130985(gene)|ensembl:ENST00000335972(transcript)|ensembl:ENST00000377351(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0004839"(ubiquitin activating enzyme activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0032446"(protein modification by small protein conjugation)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000011(Ubiquitin-activating enzyme, E1)|interpro:IPR000594(UBA/THIF-type NAD/FAD binding fold)|interpro:IPR018074|interpro:IPR018075|interpro:IPR018965|interpro:IPR019572|interpro:IPR032418|interpro:IPR032420|interpro:IPR033127|interpro:IPR035985|interpro:IPR038252|interpro:IPR042063|interpro:IPR042302|interpro:IPR042449|mint:P22314|rcsb pdb:4P22|rcsb pdb:6DC6|reactome:R-HSA-8866652|reactome:R-HSA-983168	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S2|caution:"UBE2N has been marked as the enzyme in this assay, although it is the UBE2N-UBE2V1 complex that has ubiquitinase (E3) activity. Neither UBE2N nor UBE2V1 have E2 or E3 activity on their own."|resulting-ptm:Q96FA3 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:GbzrXWXiw4Kv/zN4kEscEKPkEXQ9606	rogid:q+vEeA0XLST0Zz173bmEt0dNbDE9606	intact-crc:104734CF661979CF|rigid:7/fpP8wVrJ88Fx3e7N86U605hkg	false	-	his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q96FA3	uniprotkb:P61088	intact:EBI-448369|uniprotkb:Q96SM0|uniprotkb:Q9GZY5|uniprotkb:Q9HCX0|ensembl:ENSP00000351789	intact:EBI-1052908|uniprotkb:Q16781|uniprotkb:Q53Y81|ensembl:ENSP00000316176	psi-mi:peli1_human(display_long)|uniprotkb:Pellino-related intracellular-signaling molecule(gene name synonym)|uniprotkb:PELI1(gene name)|psi-mi:PELI1(display_short)|uniprotkb:PRISM(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase pellino homolog 1(gene name synonym)	psi-mi:ube2n_human(display_long)|uniprotkb:Ubiquitin-protein ligase N(gene name synonym)|uniprotkb:Ubiquitin carrier protein N(gene name synonym)|uniprotkb:Ubc13(gene name synonym)|uniprotkb:Bendless-like ubiquitin-conjugating enzyme(gene name synonym)|uniprotkb:UBE2N(gene name)|psi-mi:UBE2N(display_short)|uniprotkb:BLU(gene name synonym)|uniprotkb:UbcH13(gene name synonym)|uniprotkb:E2 ubiquitin-conjugating enzyme N(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9971001|imex:IM-22822-52	author-confidence:Z-score = 18.71	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_065702.2|refseq:XP_011531296.1|refseq:XP_016860009.1|dip:DIP-32488N|ensembl:ENSG00000197329(gene)|ensembl:ENST00000358912(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0008063"(Toll signaling pathway)|go:"GO:0008592"(regulation of Toll signaling pathway)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034141"(positive regulation of toll-like receptor 3 signaling pathway)|go:"GO:0034145"(positive regulation of toll-like receptor 4 signaling pathway)|go:"GO:0034450"(ubiquitin-ubiquitin ligase activity)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043331"(response to dsRNA)|go:"GO:0060544"(regulation of necroptotic process)|go:"GO:0060546"(negative regulation of necroptotic process)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0070936"(protein K48-linked ubiquitination)|interpro:IPR006800(Pellino)|mint:Q96FA3|reactome:R-HSA-5675482|reactome:R-HSA-9020702|reactome:R-HSA-937039|reactome:R-HSA-975144|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)	refseq:NP_003339.1|dip:DIP-29829N|ensembl:ENSG00000177889(gene)|ensembl:ENST00000318066(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000729"(DNA double-strand break processing)|go:"GO:0001650"(fibrillar center)|go:"GO:0003723"(RNA binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006282"(regulation of DNA repair)|go:"GO:0006301"(postreplication repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016574"(histone ubiquitination)|go:"GO:0031058"(positive regulation of histone modification)|go:"GO:0031372"(UBC13-MMS2 complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033182"(regulation of histone ubiquitination)|go:"GO:0035370"(UBC13-UEV1A complex)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0061631"(ubiquitin conjugating enzyme activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070534"(protein K63-linked ubiquitination)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|interpro:IPR023313|rcsb pdb:1J7D|rcsb pdb:2C2V|rcsb pdb:3HCT|rcsb pdb:3HCU|rcsb pdb:3VON|rcsb pdb:3W31|rcsb pdb:4DHI|rcsb pdb:4DHJ|rcsb pdb:4DHZ|rcsb pdb:4IP3|rcsb pdb:4NR3|rcsb pdb:4NRG|rcsb pdb:4NRI|rcsb pdb:4ONL|rcsb pdb:4ONM|rcsb pdb:4ONN|rcsb pdb:4ORH|rcsb pdb:4TKP|rcsb pdb:4WHV|rcsb pdb:5AIT|rcsb pdb:5AIU|rcsb pdb:5EYA|rcsb pdb:5H7S|rcsb pdb:5VNZ|rcsb pdb:5VO0|rcsb pdb:5YWR|rcsb pdb:6D6I|rcsb pdb:6JKY|rcsb pdb:6KFP|rcsb pdb:6KG6|rcsb pdb:6KL4|rcsb pdb:6LP2|rcsb pdb:6P5B|rcsb pdb:6S53|reactome:R-HSA-168927|reactome:R-HSA-202424|reactome:R-HSA-2871837|reactome:R-HSA-445989|reactome:R-HSA-450302|reactome:R-HSA-450321|reactome:R-HSA-5607764|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-5696395|reactome:R-HSA-69473|reactome:R-HSA-8866654|reactome:R-HSA-9020702|reactome:R-HSA-937039|reactome:R-HSA-937041|reactome:R-HSA-9646399|reactome:R-HSA-975110|reactome:R-HSA-975144|reactome:R-HSA-983168|rcsb pdb:6ULH|rcsb pdb:6UMP|rcsb pdb:6UMS|rcsb pdb:7BBD|rcsb pdb:7BBF|rcsb pdb:7BXG|reactome:R-HSA-1169408|reactome:R-HSA-168638	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S2|caution:"UBE2N has been marked as the enzyme in this assay, although it is the UBE2N-UBE2V1 complex that has ubiquitinase (E3) activity. Neither UBE2N nor UBE2V1 have E2 or E3 activity on their own."|resulting-ptm:Q96FA3 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:GbzrXWXiw4Kv/zN4kEscEKPkEXQ9606	rogid:dqdszHlq5FLPHC6UWX6uvkC6Yz89606	intact-crc:104734CF661979CF|rigid:7/fpP8wVrJ88Fx3e7N86U605hkg	false	-	his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q13404	uniprotkb:P22314	intact:EBI-1050671|uniprotkb:Q13403|uniprotkb:Q13532|uniprotkb:Q96H34|uniprotkb:Q9GZT0|uniprotkb:Q9GZW1|uniprotkb:Q9H4J3|uniprotkb:Q9H4J4|uniprotkb:Q9UKL1|uniprotkb:Q9UM48|uniprotkb:Q9UM49|uniprotkb:Q9UM50|uniprotkb:Q5TGE3|uniprotkb:E1P629|uniprotkb:Q5TGE0|ensembl:ENSP00000360739	intact:EBI-709688|uniprotkb:Q96E13|uniprotkb:Q5JRR8|ensembl:ENSP00000338413|ensembl:ENSP00000366568	psi-mi:ub2v1_human(display_long)|uniprotkb:CROC-1(gene name synonym)|uniprotkb:TRAF6-regulated IKK activator 1 beta Uev1A(gene name synonym)|uniprotkb:P/OKcl.19(orf name)|uniprotkb:UBE2V1(gene name)|psi-mi:UBE2V1(display_short)|uniprotkb:CROC1(gene name synonym)|uniprotkb:UBE2V(gene name synonym)|uniprotkb:UEV1(gene name synonym)	psi-mi:uba1_human(display_long)|uniprotkb:Ubiquitin-activating enzyme E1(gene name synonym)|uniprotkb:Protein A1S9(gene name synonym)|uniprotkb:UBA1(gene name)|psi-mi:UBA1(display_short)|uniprotkb:A1S9T(gene name synonym)|uniprotkb:UBE1(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9971064|imex:IM-22822-55	author-confidence:Z-score = 9.25|author-confidence:Z-score = 18.64	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001027459.1|refseq:NP_068823.2|refseq:NP_071887.1|refseq:NP_954595.1|refseq:NP_954673.1|refseq:NP_001244322.1|refseq:NP_001244323.1|refseq:NP_001244325.1|ensembl:ENSG00000244687(gene)|ensembl:ENST00000371674(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006282"(regulation of DNA repair)|go:"GO:0006301"(postreplication repair)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0030154"(cell differentiation)|go:"GO:0031371"(ubiquitin conjugating enzyme complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035370"(UBC13-UEV1A complex)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070534"(protein K63-linked ubiquitination)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|rcsb pdb:2A4D|rcsb pdb:2C2V|rcsb pdb:2HLW|rcsb pdb:6D6I|reactome:R-HSA-168638|reactome:R-HSA-168927|reactome:R-HSA-202424|reactome:R-HSA-2871837|reactome:R-HSA-445989|reactome:R-HSA-450302|reactome:R-HSA-450321|reactome:R-HSA-5607764|reactome:R-HSA-9020702|reactome:R-HSA-937039|reactome:R-HSA-937041|reactome:R-HSA-9646399|reactome:R-HSA-975110|reactome:R-HSA-975144|reactome:R-HSA-983168|dip:DIP-41911N	refseq:NP_003325.2|refseq:NP_695012.1|refseq:XP_016885269.1|refseq:XP_016885270.1|dip:DIP-33686N|ensembl:ENSG00000130985(gene)|ensembl:ENST00000335972(transcript)|ensembl:ENST00000377351(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0004839"(ubiquitin activating enzyme activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0032446"(protein modification by small protein conjugation)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000011(Ubiquitin-activating enzyme, E1)|interpro:IPR000594(UBA/THIF-type NAD/FAD binding fold)|interpro:IPR018074|interpro:IPR018075|interpro:IPR018965|interpro:IPR019572|interpro:IPR032418|interpro:IPR032420|interpro:IPR033127|interpro:IPR035985|interpro:IPR038252|interpro:IPR042063|interpro:IPR042302|interpro:IPR042449|mint:P22314|rcsb pdb:4P22|rcsb pdb:6DC6|reactome:R-HSA-8866652|reactome:R-HSA-983168	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S2|caution:"UBE2N has been marked as the enzyme in this assay, although it is the UBE2N-UBE2V1 complex that has ubiquitinase (E3) activity. Neither UBE2N nor UBE2V1 have E2 or E3 activity on their own."|resulting-ptm:Q9C0C9 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:x95N7Dj2KIqu5gySX59xLmfthUg9606	rogid:q+vEeA0XLST0Zz173bmEt0dNbDE9606	intact-crc:6BC4A31B8FC60C12|rigid:zm+NHhJxL3E2xdzFSkER8eMjF1A	false	his tag:?-?	his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q13404	uniprotkb:P61088	intact:EBI-1050671|uniprotkb:Q13403|uniprotkb:Q13532|uniprotkb:Q96H34|uniprotkb:Q9GZT0|uniprotkb:Q9GZW1|uniprotkb:Q9H4J3|uniprotkb:Q9H4J4|uniprotkb:Q9UKL1|uniprotkb:Q9UM48|uniprotkb:Q9UM49|uniprotkb:Q9UM50|uniprotkb:Q5TGE3|uniprotkb:E1P629|uniprotkb:Q5TGE0|ensembl:ENSP00000360739	intact:EBI-1052908|uniprotkb:Q16781|uniprotkb:Q53Y81|ensembl:ENSP00000316176	psi-mi:ub2v1_human(display_long)|uniprotkb:CROC-1(gene name synonym)|uniprotkb:TRAF6-regulated IKK activator 1 beta Uev1A(gene name synonym)|uniprotkb:P/OKcl.19(orf name)|uniprotkb:UBE2V1(gene name)|psi-mi:UBE2V1(display_short)|uniprotkb:CROC1(gene name synonym)|uniprotkb:UBE2V(gene name synonym)|uniprotkb:UEV1(gene name synonym)	psi-mi:ube2n_human(display_long)|uniprotkb:Ubiquitin-protein ligase N(gene name synonym)|uniprotkb:Ubiquitin carrier protein N(gene name synonym)|uniprotkb:Ubc13(gene name synonym)|uniprotkb:Bendless-like ubiquitin-conjugating enzyme(gene name synonym)|uniprotkb:UBE2N(gene name)|psi-mi:UBE2N(display_short)|uniprotkb:BLU(gene name synonym)|uniprotkb:UbcH13(gene name synonym)|uniprotkb:E2 ubiquitin-conjugating enzyme N(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9971064|imex:IM-22822-55	author-confidence:Z-score = 9.25|author-confidence:Z-score = 18.64	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001027459.1|refseq:NP_068823.2|refseq:NP_071887.1|refseq:NP_954595.1|refseq:NP_954673.1|refseq:NP_001244322.1|refseq:NP_001244323.1|refseq:NP_001244325.1|ensembl:ENSG00000244687(gene)|ensembl:ENST00000371674(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006282"(regulation of DNA repair)|go:"GO:0006301"(postreplication repair)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0030154"(cell differentiation)|go:"GO:0031371"(ubiquitin conjugating enzyme complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035370"(UBC13-UEV1A complex)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070534"(protein K63-linked ubiquitination)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|rcsb pdb:2A4D|rcsb pdb:2C2V|rcsb pdb:2HLW|rcsb pdb:6D6I|reactome:R-HSA-168638|reactome:R-HSA-168927|reactome:R-HSA-202424|reactome:R-HSA-2871837|reactome:R-HSA-445989|reactome:R-HSA-450302|reactome:R-HSA-450321|reactome:R-HSA-5607764|reactome:R-HSA-9020702|reactome:R-HSA-937039|reactome:R-HSA-937041|reactome:R-HSA-9646399|reactome:R-HSA-975110|reactome:R-HSA-975144|reactome:R-HSA-983168|dip:DIP-41911N	refseq:NP_003339.1|dip:DIP-29829N|ensembl:ENSG00000177889(gene)|ensembl:ENST00000318066(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000729"(DNA double-strand break processing)|go:"GO:0001650"(fibrillar center)|go:"GO:0003723"(RNA binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006282"(regulation of DNA repair)|go:"GO:0006301"(postreplication repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016574"(histone ubiquitination)|go:"GO:0031058"(positive regulation of histone modification)|go:"GO:0031372"(UBC13-MMS2 complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033182"(regulation of histone ubiquitination)|go:"GO:0035370"(UBC13-UEV1A complex)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0061631"(ubiquitin conjugating enzyme activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070534"(protein K63-linked ubiquitination)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|interpro:IPR023313|rcsb pdb:1J7D|rcsb pdb:2C2V|rcsb pdb:3HCT|rcsb pdb:3HCU|rcsb pdb:3VON|rcsb pdb:3W31|rcsb pdb:4DHI|rcsb pdb:4DHJ|rcsb pdb:4DHZ|rcsb pdb:4IP3|rcsb pdb:4NR3|rcsb pdb:4NRG|rcsb pdb:4NRI|rcsb pdb:4ONL|rcsb pdb:4ONM|rcsb pdb:4ONN|rcsb pdb:4ORH|rcsb pdb:4TKP|rcsb pdb:4WHV|rcsb pdb:5AIT|rcsb pdb:5AIU|rcsb pdb:5EYA|rcsb pdb:5H7S|rcsb pdb:5VNZ|rcsb pdb:5VO0|rcsb pdb:5YWR|rcsb pdb:6D6I|rcsb pdb:6JKY|rcsb pdb:6KFP|rcsb pdb:6KG6|rcsb pdb:6KL4|rcsb pdb:6LP2|rcsb pdb:6P5B|rcsb pdb:6S53|reactome:R-HSA-168927|reactome:R-HSA-202424|reactome:R-HSA-2871837|reactome:R-HSA-445989|reactome:R-HSA-450302|reactome:R-HSA-450321|reactome:R-HSA-5607764|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-5696395|reactome:R-HSA-69473|reactome:R-HSA-8866654|reactome:R-HSA-9020702|reactome:R-HSA-937039|reactome:R-HSA-937041|reactome:R-HSA-9646399|reactome:R-HSA-975110|reactome:R-HSA-975144|reactome:R-HSA-983168|rcsb pdb:6ULH|rcsb pdb:6UMP|rcsb pdb:6UMS|rcsb pdb:7BBD|rcsb pdb:7BBF|rcsb pdb:7BXG|reactome:R-HSA-1169408|reactome:R-HSA-168638	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S2|caution:"UBE2N has been marked as the enzyme in this assay, although it is the UBE2N-UBE2V1 complex that has ubiquitinase (E3) activity. Neither UBE2N nor UBE2V1 have E2 or E3 activity on their own."|resulting-ptm:Q9C0C9 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:x95N7Dj2KIqu5gySX59xLmfthUg9606	rogid:dqdszHlq5FLPHC6UWX6uvkC6Yz89606	intact-crc:6BC4A31B8FC60C12|rigid:zm+NHhJxL3E2xdzFSkER8eMjF1A	false	his tag:?-?	his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q13404	uniprotkb:Q9C0C9	intact:EBI-1050671|uniprotkb:Q13403|uniprotkb:Q13532|uniprotkb:Q96H34|uniprotkb:Q9GZT0|uniprotkb:Q9GZW1|uniprotkb:Q9H4J3|uniprotkb:Q9H4J4|uniprotkb:Q9UKL1|uniprotkb:Q9UM48|uniprotkb:Q9UM49|uniprotkb:Q9UM50|uniprotkb:Q5TGE3|uniprotkb:E1P629|uniprotkb:Q5TGE0|ensembl:ENSP00000360739	intact:EBI-2339946|uniprotkb:Q8N425|uniprotkb:Q9H9B2|uniprotkb:Q6PIZ2|uniprotkb:Q9H7E4|uniprotkb:Q8TBN1|uniprotkb:A6NDU5|uniprotkb:Q9BSW1|uniprotkb:Q69YP4|uniprotkb:Q86UA4|uniprotkb:Q9H6E6|ensembl:ENSP00000323687	psi-mi:ub2v1_human(display_long)|uniprotkb:CROC-1(gene name synonym)|uniprotkb:TRAF6-regulated IKK activator 1 beta Uev1A(gene name synonym)|uniprotkb:P/OKcl.19(orf name)|uniprotkb:UBE2V1(gene name)|psi-mi:UBE2V1(display_short)|uniprotkb:CROC1(gene name synonym)|uniprotkb:UBE2V(gene name synonym)|uniprotkb:UEV1(gene name synonym)	psi-mi:ube2o_human(display_long)|uniprotkb:UBE2O(gene name)|psi-mi:UBE2O(display_short)|uniprotkb:KIAA1734(gene name synonym)|uniprotkb:Ubiquitin-protein ligase O(gene name synonym)|uniprotkb:Ubiquitin carrier protein O(gene name synonym)|uniprotkb:Ubiquitin-conjugating enzyme E2 of 230 kDa(gene name synonym)|uniprotkb:Ubiquitin-conjugating enzyme E2 O(gene name synonym)|uniprotkb:E2/E3 hybrid ubiquitin-protein ligase UBE2O(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9971064|imex:IM-22822-55	author-confidence:Z-score = 9.25|author-confidence:Z-score = 18.64	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001027459.1|refseq:NP_068823.2|refseq:NP_071887.1|refseq:NP_954595.1|refseq:NP_954673.1|refseq:NP_001244322.1|refseq:NP_001244323.1|refseq:NP_001244325.1|ensembl:ENSG00000244687(gene)|ensembl:ENST00000371674(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006282"(regulation of DNA repair)|go:"GO:0006301"(postreplication repair)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0030154"(cell differentiation)|go:"GO:0031371"(ubiquitin conjugating enzyme complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035370"(UBC13-UEV1A complex)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070534"(protein K63-linked ubiquitination)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|rcsb pdb:2A4D|rcsb pdb:2C2V|rcsb pdb:2HLW|rcsb pdb:6D6I|reactome:R-HSA-168638|reactome:R-HSA-168927|reactome:R-HSA-202424|reactome:R-HSA-2871837|reactome:R-HSA-445989|reactome:R-HSA-450302|reactome:R-HSA-450321|reactome:R-HSA-5607764|reactome:R-HSA-9020702|reactome:R-HSA-937039|reactome:R-HSA-937041|reactome:R-HSA-9646399|reactome:R-HSA-975110|reactome:R-HSA-975144|reactome:R-HSA-983168|dip:DIP-41911N	refseq:NP_071349.3|ensembl:ENSG00000175931(gene)|ensembl:ENST00000319380(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0004869"(cysteine-type endopeptidase inhibitor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006513"(protein monoubiquitination)|go:"GO:0016604"(nuclear body)|go:"GO:0030513"(positive regulation of BMP signaling pathway)|go:"GO:0042147"(retrograde transport, endosome to Golgi)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0061631"(ubiquitin conjugating enzyme activity)|go:"GO:0070534"(protein K63-linked ubiquitination)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|mint:Q9C0C9|reactome:R-HSA-983168	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S2|caution:"UBE2N has been marked as the enzyme in this assay, although it is the UBE2N-UBE2V1 complex that has ubiquitinase (E3) activity. Neither UBE2N nor UBE2V1 have E2 or E3 activity on their own."|resulting-ptm:Q9C0C9 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:x95N7Dj2KIqu5gySX59xLmfthUg9606	rogid:FftBetvip/qFQAsQxmxRnGy8ctA9606	intact-crc:6BC4A31B8FC60C12|rigid:zm+NHhJxL3E2xdzFSkER8eMjF1A	false	his tag:?-?	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q96LR5	uniprotkb:Q13404	intact:EBI-2129763|ensembl:ENSP00000379931|ensembl:ENSP00000401053	intact:EBI-1050671|uniprotkb:Q13403|uniprotkb:Q13532|uniprotkb:Q96H34|uniprotkb:Q9GZT0|uniprotkb:Q9GZW1|uniprotkb:Q9H4J3|uniprotkb:Q9H4J4|uniprotkb:Q9UKL1|uniprotkb:Q9UM48|uniprotkb:Q9UM49|uniprotkb:Q9UM50|uniprotkb:Q5TGE3|uniprotkb:E1P629|uniprotkb:Q5TGE0|ensembl:ENSP00000360739	psi-mi:ub2e2_human(display_long)|uniprotkb:UBE2E2(gene name)|psi-mi:UBE2E2(display_short)|uniprotkb:UBCH8(gene name synonym)|uniprotkb:Ubiquitin-protein ligase E2(gene name synonym)|uniprotkb:Ubiquitin carrier protein E2(gene name synonym)|uniprotkb:UbcH8(gene name synonym)|uniprotkb:E2 ubiquitin-conjugating enzyme E2(gene name synonym)	psi-mi:ub2v1_human(display_long)|uniprotkb:CROC-1(gene name synonym)|uniprotkb:TRAF6-regulated IKK activator 1 beta Uev1A(gene name synonym)|uniprotkb:P/OKcl.19(orf name)|uniprotkb:UBE2V1(gene name)|psi-mi:UBE2V1(display_short)|uniprotkb:CROC1(gene name synonym)|uniprotkb:UBE2V(gene name synonym)|uniprotkb:UEV1(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9971043|imex:IM-22822-54	author-confidence:Z-score = 10.63	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_689866.1|ensembl:ENSG00000182247(gene)|ensembl:ENST00000396703(transcript)|ensembl:ENST00000425792(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0032020"(ISG15-protein conjugation)|go:"GO:0042296"(ISG15 transferase activity)|go:"GO:0061631"(ubiquitin conjugating enzyme activity)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0070936"(protein K48-linked ubiquitination)|go:"GO:0070979"(protein K11-linked ubiquitination)|go:"GO:1900087"(positive regulation of G1/S transition of mitotic cell cycle)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|interpro:IPR023313|rcsb pdb:1Y6L|rcsb pdb:6W9A|reactome:R-HSA-983168|refseq:XP_005265489.1|dip:DIP-52704N	refseq:NP_001027459.1|refseq:NP_068823.2|refseq:NP_071887.1|refseq:NP_954595.1|refseq:NP_954673.1|refseq:NP_001244322.1|refseq:NP_001244323.1|refseq:NP_001244325.1|ensembl:ENSG00000244687(gene)|ensembl:ENST00000371674(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006282"(regulation of DNA repair)|go:"GO:0006301"(postreplication repair)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0030154"(cell differentiation)|go:"GO:0031371"(ubiquitin conjugating enzyme complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035370"(UBC13-UEV1A complex)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070534"(protein K63-linked ubiquitination)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|rcsb pdb:2A4D|rcsb pdb:2C2V|rcsb pdb:2HLW|rcsb pdb:6D6I|reactome:R-HSA-168638|reactome:R-HSA-168927|reactome:R-HSA-202424|reactome:R-HSA-2871837|reactome:R-HSA-445989|reactome:R-HSA-450302|reactome:R-HSA-450321|reactome:R-HSA-5607764|reactome:R-HSA-9020702|reactome:R-HSA-937039|reactome:R-HSA-937041|reactome:R-HSA-9646399|reactome:R-HSA-975110|reactome:R-HSA-975144|reactome:R-HSA-983168|dip:DIP-41911N	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S2|caution:"UBE2N has been marked as the enzyme in this assay, although it is the UBE2N-UBE2V1 complex that has ubiquitinase (E3) activity. Neither UBE2N nor UBE2V1 have E2 or E3 activity on their own."|resulting-ptm:Q96LR5 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:wg1dG8oCGSZ7871YMQRSFEbmcEo9606	rogid:x95N7Dj2KIqu5gySX59xLmfthUg9606	intact-crc:F2688FDD5A2BC9B0|rigid:zdFxdeAroPxpg+klemCiVqY/V/s	false	-	his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q96LR5	uniprotkb:P22314	intact:EBI-2129763|ensembl:ENSP00000379931|ensembl:ENSP00000401053	intact:EBI-709688|uniprotkb:Q96E13|uniprotkb:Q5JRR8|ensembl:ENSP00000338413|ensembl:ENSP00000366568	psi-mi:ub2e2_human(display_long)|uniprotkb:UBE2E2(gene name)|psi-mi:UBE2E2(display_short)|uniprotkb:UBCH8(gene name synonym)|uniprotkb:Ubiquitin-protein ligase E2(gene name synonym)|uniprotkb:Ubiquitin carrier protein E2(gene name synonym)|uniprotkb:UbcH8(gene name synonym)|uniprotkb:E2 ubiquitin-conjugating enzyme E2(gene name synonym)	psi-mi:uba1_human(display_long)|uniprotkb:Ubiquitin-activating enzyme E1(gene name synonym)|uniprotkb:Protein A1S9(gene name synonym)|uniprotkb:UBA1(gene name)|psi-mi:UBA1(display_short)|uniprotkb:A1S9T(gene name synonym)|uniprotkb:UBE1(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9971043|imex:IM-22822-54	author-confidence:Z-score = 10.63	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_689866.1|ensembl:ENSG00000182247(gene)|ensembl:ENST00000396703(transcript)|ensembl:ENST00000425792(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0032020"(ISG15-protein conjugation)|go:"GO:0042296"(ISG15 transferase activity)|go:"GO:0061631"(ubiquitin conjugating enzyme activity)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0070936"(protein K48-linked ubiquitination)|go:"GO:0070979"(protein K11-linked ubiquitination)|go:"GO:1900087"(positive regulation of G1/S transition of mitotic cell cycle)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|interpro:IPR023313|rcsb pdb:1Y6L|rcsb pdb:6W9A|reactome:R-HSA-983168|refseq:XP_005265489.1|dip:DIP-52704N	refseq:NP_003325.2|refseq:NP_695012.1|refseq:XP_016885269.1|refseq:XP_016885270.1|dip:DIP-33686N|ensembl:ENSG00000130985(gene)|ensembl:ENST00000335972(transcript)|ensembl:ENST00000377351(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0004839"(ubiquitin activating enzyme activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0032446"(protein modification by small protein conjugation)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000011(Ubiquitin-activating enzyme, E1)|interpro:IPR000594(UBA/THIF-type NAD/FAD binding fold)|interpro:IPR018074|interpro:IPR018075|interpro:IPR018965|interpro:IPR019572|interpro:IPR032418|interpro:IPR032420|interpro:IPR033127|interpro:IPR035985|interpro:IPR038252|interpro:IPR042063|interpro:IPR042302|interpro:IPR042449|mint:P22314|rcsb pdb:4P22|rcsb pdb:6DC6|reactome:R-HSA-8866652|reactome:R-HSA-983168	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S2|caution:"UBE2N has been marked as the enzyme in this assay, although it is the UBE2N-UBE2V1 complex that has ubiquitinase (E3) activity. Neither UBE2N nor UBE2V1 have E2 or E3 activity on their own."|resulting-ptm:Q96LR5 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:wg1dG8oCGSZ7871YMQRSFEbmcEo9606	rogid:q+vEeA0XLST0Zz173bmEt0dNbDE9606	intact-crc:F2688FDD5A2BC9B0|rigid:zdFxdeAroPxpg+klemCiVqY/V/s	false	-	his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q96LR5	uniprotkb:P61088	intact:EBI-2129763|ensembl:ENSP00000379931|ensembl:ENSP00000401053	intact:EBI-1052908|uniprotkb:Q16781|uniprotkb:Q53Y81|ensembl:ENSP00000316176	psi-mi:ub2e2_human(display_long)|uniprotkb:UBE2E2(gene name)|psi-mi:UBE2E2(display_short)|uniprotkb:UBCH8(gene name synonym)|uniprotkb:Ubiquitin-protein ligase E2(gene name synonym)|uniprotkb:Ubiquitin carrier protein E2(gene name synonym)|uniprotkb:UbcH8(gene name synonym)|uniprotkb:E2 ubiquitin-conjugating enzyme E2(gene name synonym)	psi-mi:ube2n_human(display_long)|uniprotkb:Ubiquitin-protein ligase N(gene name synonym)|uniprotkb:Ubiquitin carrier protein N(gene name synonym)|uniprotkb:Ubc13(gene name synonym)|uniprotkb:Bendless-like ubiquitin-conjugating enzyme(gene name synonym)|uniprotkb:UBE2N(gene name)|psi-mi:UBE2N(display_short)|uniprotkb:BLU(gene name synonym)|uniprotkb:UbcH13(gene name synonym)|uniprotkb:E2 ubiquitin-conjugating enzyme N(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9971043|imex:IM-22822-54	author-confidence:Z-score = 10.63	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_689866.1|ensembl:ENSG00000182247(gene)|ensembl:ENST00000396703(transcript)|ensembl:ENST00000425792(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0032020"(ISG15-protein conjugation)|go:"GO:0042296"(ISG15 transferase activity)|go:"GO:0061631"(ubiquitin conjugating enzyme activity)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0070936"(protein K48-linked ubiquitination)|go:"GO:0070979"(protein K11-linked ubiquitination)|go:"GO:1900087"(positive regulation of G1/S transition of mitotic cell cycle)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|interpro:IPR023313|rcsb pdb:1Y6L|rcsb pdb:6W9A|reactome:R-HSA-983168|refseq:XP_005265489.1|dip:DIP-52704N	refseq:NP_003339.1|dip:DIP-29829N|ensembl:ENSG00000177889(gene)|ensembl:ENST00000318066(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000729"(DNA double-strand break processing)|go:"GO:0001650"(fibrillar center)|go:"GO:0003723"(RNA binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006282"(regulation of DNA repair)|go:"GO:0006301"(postreplication repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016574"(histone ubiquitination)|go:"GO:0031058"(positive regulation of histone modification)|go:"GO:0031372"(UBC13-MMS2 complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033182"(regulation of histone ubiquitination)|go:"GO:0035370"(UBC13-UEV1A complex)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0061631"(ubiquitin conjugating enzyme activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070534"(protein K63-linked ubiquitination)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|interpro:IPR023313|rcsb pdb:1J7D|rcsb pdb:2C2V|rcsb pdb:3HCT|rcsb pdb:3HCU|rcsb pdb:3VON|rcsb pdb:3W31|rcsb pdb:4DHI|rcsb pdb:4DHJ|rcsb pdb:4DHZ|rcsb pdb:4IP3|rcsb pdb:4NR3|rcsb pdb:4NRG|rcsb pdb:4NRI|rcsb pdb:4ONL|rcsb pdb:4ONM|rcsb pdb:4ONN|rcsb pdb:4ORH|rcsb pdb:4TKP|rcsb pdb:4WHV|rcsb pdb:5AIT|rcsb pdb:5AIU|rcsb pdb:5EYA|rcsb pdb:5H7S|rcsb pdb:5VNZ|rcsb pdb:5VO0|rcsb pdb:5YWR|rcsb pdb:6D6I|rcsb pdb:6JKY|rcsb pdb:6KFP|rcsb pdb:6KG6|rcsb pdb:6KL4|rcsb pdb:6LP2|rcsb pdb:6P5B|rcsb pdb:6S53|reactome:R-HSA-168927|reactome:R-HSA-202424|reactome:R-HSA-2871837|reactome:R-HSA-445989|reactome:R-HSA-450302|reactome:R-HSA-450321|reactome:R-HSA-5607764|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-5696395|reactome:R-HSA-69473|reactome:R-HSA-8866654|reactome:R-HSA-9020702|reactome:R-HSA-937039|reactome:R-HSA-937041|reactome:R-HSA-9646399|reactome:R-HSA-975110|reactome:R-HSA-975144|reactome:R-HSA-983168|rcsb pdb:6ULH|rcsb pdb:6UMP|rcsb pdb:6UMS|rcsb pdb:7BBD|rcsb pdb:7BBF|rcsb pdb:7BXG|reactome:R-HSA-1169408|reactome:R-HSA-168638	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S2|caution:"UBE2N has been marked as the enzyme in this assay, although it is the UBE2N-UBE2V1 complex that has ubiquitinase (E3) activity. Neither UBE2N nor UBE2V1 have E2 or E3 activity on their own."|resulting-ptm:Q96LR5 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:wg1dG8oCGSZ7871YMQRSFEbmcEo9606	rogid:dqdszHlq5FLPHC6UWX6uvkC6Yz89606	intact-crc:F2688FDD5A2BC9B0|rigid:zdFxdeAroPxpg+klemCiVqY/V/s	false	-	his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q96FV3	uniprotkb:Q13404	intact:EBI-1044605|uniprotkb:Q6NXF7|uniprotkb:Q96S98|uniprotkb:Q9UKB9	intact:EBI-1050671|uniprotkb:Q13403|uniprotkb:Q13532|uniprotkb:Q96H34|uniprotkb:Q9GZT0|uniprotkb:Q9GZW1|uniprotkb:Q9H4J3|uniprotkb:Q9H4J4|uniprotkb:Q9UKL1|uniprotkb:Q9UM48|uniprotkb:Q9UM49|uniprotkb:Q9UM50|uniprotkb:Q5TGE3|uniprotkb:E1P629|uniprotkb:Q5TGE0|ensembl:ENSP00000360739	psi-mi:tsn17_human(display_long)|uniprotkb:Transmembrane 4 superfamily member 17(gene name synonym)|uniprotkb:Tetraspan protein SB134(gene name synonym)|uniprotkb:F-box only protein 23(gene name synonym)|uniprotkb:TSPAN17(gene name)|psi-mi:TSPAN17(display_short)|uniprotkb:FBXO23(gene name synonym)|uniprotkb:TM4SF17(gene name synonym)	psi-mi:ub2v1_human(display_long)|uniprotkb:CROC-1(gene name synonym)|uniprotkb:TRAF6-regulated IKK activator 1 beta Uev1A(gene name synonym)|uniprotkb:P/OKcl.19(orf name)|uniprotkb:UBE2V1(gene name)|psi-mi:UBE2V1(display_short)|uniprotkb:CROC1(gene name synonym)|uniprotkb:UBE2V(gene name synonym)|uniprotkb:UEV1(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9971022|imex:IM-22822-53	author-confidence:Z-score = 10.09	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001006617.2|refseq:NP_569732.2|interpro:IPR018499|interpro:IPR018503|interpro:IPR008952(Tetraspanin)|interpro:IPR000301(CD9/CD37/CD63 antigen)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019899"(enzyme binding)|go:"GO:0051604"(protein maturation)|go:"GO:0072594"(establishment of protein localization to organelle)|go:"GO:0072659"(protein localization to plasma membrane)	refseq:NP_001027459.1|refseq:NP_068823.2|refseq:NP_071887.1|refseq:NP_954595.1|refseq:NP_954673.1|refseq:NP_001244322.1|refseq:NP_001244323.1|refseq:NP_001244325.1|ensembl:ENSG00000244687(gene)|ensembl:ENST00000371674(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006282"(regulation of DNA repair)|go:"GO:0006301"(postreplication repair)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0030154"(cell differentiation)|go:"GO:0031371"(ubiquitin conjugating enzyme complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035370"(UBC13-UEV1A complex)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070534"(protein K63-linked ubiquitination)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|rcsb pdb:2A4D|rcsb pdb:2C2V|rcsb pdb:2HLW|rcsb pdb:6D6I|reactome:R-HSA-168638|reactome:R-HSA-168927|reactome:R-HSA-202424|reactome:R-HSA-2871837|reactome:R-HSA-445989|reactome:R-HSA-450302|reactome:R-HSA-450321|reactome:R-HSA-5607764|reactome:R-HSA-9020702|reactome:R-HSA-937039|reactome:R-HSA-937041|reactome:R-HSA-9646399|reactome:R-HSA-975110|reactome:R-HSA-975144|reactome:R-HSA-983168|dip:DIP-41911N	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S2|caution:"UBE2N has been marked as the enzyme in this assay, although it is the UBE2N-UBE2V1 complex that has ubiquitinase (E3) activity. Neither UBE2N nor UBE2V1 have E2 or E3 activity on their own."|resulting-ptm:Q96FV3 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:HOPpE7QCQ9UCGiknlVGihQtD8Ss9606	rogid:x95N7Dj2KIqu5gySX59xLmfthUg9606	intact-crc:6453B701316033D7|rigid:FLTiUvclzKX7Iz5UjOtFuxZDyZM	false	-	his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q96FV3	uniprotkb:P22314	intact:EBI-1044605|uniprotkb:Q6NXF7|uniprotkb:Q96S98|uniprotkb:Q9UKB9	intact:EBI-709688|uniprotkb:Q96E13|uniprotkb:Q5JRR8|ensembl:ENSP00000338413|ensembl:ENSP00000366568	psi-mi:tsn17_human(display_long)|uniprotkb:Transmembrane 4 superfamily member 17(gene name synonym)|uniprotkb:Tetraspan protein SB134(gene name synonym)|uniprotkb:F-box only protein 23(gene name synonym)|uniprotkb:TSPAN17(gene name)|psi-mi:TSPAN17(display_short)|uniprotkb:FBXO23(gene name synonym)|uniprotkb:TM4SF17(gene name synonym)	psi-mi:uba1_human(display_long)|uniprotkb:Ubiquitin-activating enzyme E1(gene name synonym)|uniprotkb:Protein A1S9(gene name synonym)|uniprotkb:UBA1(gene name)|psi-mi:UBA1(display_short)|uniprotkb:A1S9T(gene name synonym)|uniprotkb:UBE1(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9971022|imex:IM-22822-53	author-confidence:Z-score = 10.09	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001006617.2|refseq:NP_569732.2|interpro:IPR018499|interpro:IPR018503|interpro:IPR008952(Tetraspanin)|interpro:IPR000301(CD9/CD37/CD63 antigen)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019899"(enzyme binding)|go:"GO:0051604"(protein maturation)|go:"GO:0072594"(establishment of protein localization to organelle)|go:"GO:0072659"(protein localization to plasma membrane)	refseq:NP_003325.2|refseq:NP_695012.1|refseq:XP_016885269.1|refseq:XP_016885270.1|dip:DIP-33686N|ensembl:ENSG00000130985(gene)|ensembl:ENST00000335972(transcript)|ensembl:ENST00000377351(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0004839"(ubiquitin activating enzyme activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0032446"(protein modification by small protein conjugation)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000011(Ubiquitin-activating enzyme, E1)|interpro:IPR000594(UBA/THIF-type NAD/FAD binding fold)|interpro:IPR018074|interpro:IPR018075|interpro:IPR018965|interpro:IPR019572|interpro:IPR032418|interpro:IPR032420|interpro:IPR033127|interpro:IPR035985|interpro:IPR038252|interpro:IPR042063|interpro:IPR042302|interpro:IPR042449|mint:P22314|rcsb pdb:4P22|rcsb pdb:6DC6|reactome:R-HSA-8866652|reactome:R-HSA-983168	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S2|caution:"UBE2N has been marked as the enzyme in this assay, although it is the UBE2N-UBE2V1 complex that has ubiquitinase (E3) activity. Neither UBE2N nor UBE2V1 have E2 or E3 activity on their own."|resulting-ptm:Q96FV3 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:HOPpE7QCQ9UCGiknlVGihQtD8Ss9606	rogid:q+vEeA0XLST0Zz173bmEt0dNbDE9606	intact-crc:6453B701316033D7|rigid:FLTiUvclzKX7Iz5UjOtFuxZDyZM	false	-	his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q96FV3	uniprotkb:P61088	intact:EBI-1044605|uniprotkb:Q6NXF7|uniprotkb:Q96S98|uniprotkb:Q9UKB9	intact:EBI-1052908|uniprotkb:Q16781|uniprotkb:Q53Y81|ensembl:ENSP00000316176	psi-mi:tsn17_human(display_long)|uniprotkb:Transmembrane 4 superfamily member 17(gene name synonym)|uniprotkb:Tetraspan protein SB134(gene name synonym)|uniprotkb:F-box only protein 23(gene name synonym)|uniprotkb:TSPAN17(gene name)|psi-mi:TSPAN17(display_short)|uniprotkb:FBXO23(gene name synonym)|uniprotkb:TM4SF17(gene name synonym)	psi-mi:ube2n_human(display_long)|uniprotkb:Ubiquitin-protein ligase N(gene name synonym)|uniprotkb:Ubiquitin carrier protein N(gene name synonym)|uniprotkb:Ubc13(gene name synonym)|uniprotkb:Bendless-like ubiquitin-conjugating enzyme(gene name synonym)|uniprotkb:UBE2N(gene name)|psi-mi:UBE2N(display_short)|uniprotkb:BLU(gene name synonym)|uniprotkb:UbcH13(gene name synonym)|uniprotkb:E2 ubiquitin-conjugating enzyme N(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9971022|imex:IM-22822-53	author-confidence:Z-score = 10.09	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001006617.2|refseq:NP_569732.2|interpro:IPR018499|interpro:IPR018503|interpro:IPR008952(Tetraspanin)|interpro:IPR000301(CD9/CD37/CD63 antigen)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019899"(enzyme binding)|go:"GO:0051604"(protein maturation)|go:"GO:0072594"(establishment of protein localization to organelle)|go:"GO:0072659"(protein localization to plasma membrane)	refseq:NP_003339.1|dip:DIP-29829N|ensembl:ENSG00000177889(gene)|ensembl:ENST00000318066(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000729"(DNA double-strand break processing)|go:"GO:0001650"(fibrillar center)|go:"GO:0003723"(RNA binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006282"(regulation of DNA repair)|go:"GO:0006301"(postreplication repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016574"(histone ubiquitination)|go:"GO:0031058"(positive regulation of histone modification)|go:"GO:0031372"(UBC13-MMS2 complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033182"(regulation of histone ubiquitination)|go:"GO:0035370"(UBC13-UEV1A complex)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0061631"(ubiquitin conjugating enzyme activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070534"(protein K63-linked ubiquitination)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|interpro:IPR023313|rcsb pdb:1J7D|rcsb pdb:2C2V|rcsb pdb:3HCT|rcsb pdb:3HCU|rcsb pdb:3VON|rcsb pdb:3W31|rcsb pdb:4DHI|rcsb pdb:4DHJ|rcsb pdb:4DHZ|rcsb pdb:4IP3|rcsb pdb:4NR3|rcsb pdb:4NRG|rcsb pdb:4NRI|rcsb pdb:4ONL|rcsb pdb:4ONM|rcsb pdb:4ONN|rcsb pdb:4ORH|rcsb pdb:4TKP|rcsb pdb:4WHV|rcsb pdb:5AIT|rcsb pdb:5AIU|rcsb pdb:5EYA|rcsb pdb:5H7S|rcsb pdb:5VNZ|rcsb pdb:5VO0|rcsb pdb:5YWR|rcsb pdb:6D6I|rcsb pdb:6JKY|rcsb pdb:6KFP|rcsb pdb:6KG6|rcsb pdb:6KL4|rcsb pdb:6LP2|rcsb pdb:6P5B|rcsb pdb:6S53|reactome:R-HSA-168927|reactome:R-HSA-202424|reactome:R-HSA-2871837|reactome:R-HSA-445989|reactome:R-HSA-450302|reactome:R-HSA-450321|reactome:R-HSA-5607764|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-5696395|reactome:R-HSA-69473|reactome:R-HSA-8866654|reactome:R-HSA-9020702|reactome:R-HSA-937039|reactome:R-HSA-937041|reactome:R-HSA-9646399|reactome:R-HSA-975110|reactome:R-HSA-975144|reactome:R-HSA-983168|rcsb pdb:6ULH|rcsb pdb:6UMP|rcsb pdb:6UMS|rcsb pdb:7BBD|rcsb pdb:7BBF|rcsb pdb:7BXG|reactome:R-HSA-1169408|reactome:R-HSA-168638	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S2|caution:"UBE2N has been marked as the enzyme in this assay, although it is the UBE2N-UBE2V1 complex that has ubiquitinase (E3) activity. Neither UBE2N nor UBE2V1 have E2 or E3 activity on their own."|resulting-ptm:Q96FV3 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:HOPpE7QCQ9UCGiknlVGihQtD8Ss9606	rogid:dqdszHlq5FLPHC6UWX6uvkC6Yz89606	intact-crc:6453B701316033D7|rigid:FLTiUvclzKX7Iz5UjOtFuxZDyZM	false	-	his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9HAT8	uniprotkb:Q13404	intact:EBI-448407|uniprotkb:B2RDY5|ensembl:ENSP00000267460	intact:EBI-1050671|uniprotkb:Q13403|uniprotkb:Q13532|uniprotkb:Q96H34|uniprotkb:Q9GZT0|uniprotkb:Q9GZW1|uniprotkb:Q9H4J3|uniprotkb:Q9H4J4|uniprotkb:Q9UKL1|uniprotkb:Q9UM48|uniprotkb:Q9UM49|uniprotkb:Q9UM50|uniprotkb:Q5TGE3|uniprotkb:E1P629|uniprotkb:Q5TGE0|ensembl:ENSP00000360739	psi-mi:peli2_human(display_long)|uniprotkb:PELI2(gene name)|psi-mi:PELI2(display_short)|uniprotkb:RING-type E3 ubiquitin transferase pellino homolog 2(gene name synonym)	psi-mi:ub2v1_human(display_long)|uniprotkb:CROC-1(gene name synonym)|uniprotkb:TRAF6-regulated IKK activator 1 beta Uev1A(gene name synonym)|uniprotkb:P/OKcl.19(orf name)|uniprotkb:UBE2V1(gene name)|psi-mi:UBE2V1(display_short)|uniprotkb:CROC1(gene name synonym)|uniprotkb:UBE2V(gene name synonym)|uniprotkb:UEV1(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9971107|imex:IM-22822-57	author-confidence:Z-score = 13.16	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067078.1|dip:DIP-31350N|ensembl:ENSG00000139946(gene)|ensembl:ENST00000267460(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0005829"(cytosol)|go:"GO:0008063"(Toll signaling pathway)|go:"GO:0008592"(regulation of Toll signaling pathway)|go:"GO:0034450"(ubiquitin-ubiquitin ligase activity)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0061630"(ubiquitin protein ligase activity)|interpro:IPR006800(Pellino)|mint:Q9HAT8|rcsb pdb:3EGA|rcsb pdb:3EGB|reactome:R-HSA-9020702|reactome:R-HSA-937039|reactome:R-HSA-975144	refseq:NP_001027459.1|refseq:NP_068823.2|refseq:NP_071887.1|refseq:NP_954595.1|refseq:NP_954673.1|refseq:NP_001244322.1|refseq:NP_001244323.1|refseq:NP_001244325.1|ensembl:ENSG00000244687(gene)|ensembl:ENST00000371674(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006282"(regulation of DNA repair)|go:"GO:0006301"(postreplication repair)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0030154"(cell differentiation)|go:"GO:0031371"(ubiquitin conjugating enzyme complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035370"(UBC13-UEV1A complex)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070534"(protein K63-linked ubiquitination)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|rcsb pdb:2A4D|rcsb pdb:2C2V|rcsb pdb:2HLW|rcsb pdb:6D6I|reactome:R-HSA-168638|reactome:R-HSA-168927|reactome:R-HSA-202424|reactome:R-HSA-2871837|reactome:R-HSA-445989|reactome:R-HSA-450302|reactome:R-HSA-450321|reactome:R-HSA-5607764|reactome:R-HSA-9020702|reactome:R-HSA-937039|reactome:R-HSA-937041|reactome:R-HSA-9646399|reactome:R-HSA-975110|reactome:R-HSA-975144|reactome:R-HSA-983168|dip:DIP-41911N	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S2|caution:"UBE2N has been marked as the enzyme in this assay, although it is the UBE2N-UBE2V1 complex that has ubiquitinase (E3) activity. Neither UBE2N nor UBE2V1 have E2 or E3 activity on their own."|resulting-ptm:Q9HAT8 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:Inw0l7txoS2SolLj5tAYnHd61Gs9606	rogid:x95N7Dj2KIqu5gySX59xLmfthUg9606	intact-crc:638236373570ED54|rigid:w/0bMr1w3rSrJ7cgnOaObOkto80	false	-	his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9HAT8	uniprotkb:P22314	intact:EBI-448407|uniprotkb:B2RDY5|ensembl:ENSP00000267460	intact:EBI-709688|uniprotkb:Q96E13|uniprotkb:Q5JRR8|ensembl:ENSP00000338413|ensembl:ENSP00000366568	psi-mi:peli2_human(display_long)|uniprotkb:PELI2(gene name)|psi-mi:PELI2(display_short)|uniprotkb:RING-type E3 ubiquitin transferase pellino homolog 2(gene name synonym)	psi-mi:uba1_human(display_long)|uniprotkb:Ubiquitin-activating enzyme E1(gene name synonym)|uniprotkb:Protein A1S9(gene name synonym)|uniprotkb:UBA1(gene name)|psi-mi:UBA1(display_short)|uniprotkb:A1S9T(gene name synonym)|uniprotkb:UBE1(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9971107|imex:IM-22822-57	author-confidence:Z-score = 13.16	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067078.1|dip:DIP-31350N|ensembl:ENSG00000139946(gene)|ensembl:ENST00000267460(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0005829"(cytosol)|go:"GO:0008063"(Toll signaling pathway)|go:"GO:0008592"(regulation of Toll signaling pathway)|go:"GO:0034450"(ubiquitin-ubiquitin ligase activity)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0061630"(ubiquitin protein ligase activity)|interpro:IPR006800(Pellino)|mint:Q9HAT8|rcsb pdb:3EGA|rcsb pdb:3EGB|reactome:R-HSA-9020702|reactome:R-HSA-937039|reactome:R-HSA-975144	refseq:NP_003325.2|refseq:NP_695012.1|refseq:XP_016885269.1|refseq:XP_016885270.1|dip:DIP-33686N|ensembl:ENSG00000130985(gene)|ensembl:ENST00000335972(transcript)|ensembl:ENST00000377351(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0004839"(ubiquitin activating enzyme activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0032446"(protein modification by small protein conjugation)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000011(Ubiquitin-activating enzyme, E1)|interpro:IPR000594(UBA/THIF-type NAD/FAD binding fold)|interpro:IPR018074|interpro:IPR018075|interpro:IPR018965|interpro:IPR019572|interpro:IPR032418|interpro:IPR032420|interpro:IPR033127|interpro:IPR035985|interpro:IPR038252|interpro:IPR042063|interpro:IPR042302|interpro:IPR042449|mint:P22314|rcsb pdb:4P22|rcsb pdb:6DC6|reactome:R-HSA-8866652|reactome:R-HSA-983168	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S2|caution:"UBE2N has been marked as the enzyme in this assay, although it is the UBE2N-UBE2V1 complex that has ubiquitinase (E3) activity. Neither UBE2N nor UBE2V1 have E2 or E3 activity on their own."|resulting-ptm:Q9HAT8 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:Inw0l7txoS2SolLj5tAYnHd61Gs9606	rogid:q+vEeA0XLST0Zz173bmEt0dNbDE9606	intact-crc:638236373570ED54|rigid:w/0bMr1w3rSrJ7cgnOaObOkto80	false	-	his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9HAT8	uniprotkb:P61088	intact:EBI-448407|uniprotkb:B2RDY5|ensembl:ENSP00000267460	intact:EBI-1052908|uniprotkb:Q16781|uniprotkb:Q53Y81|ensembl:ENSP00000316176	psi-mi:peli2_human(display_long)|uniprotkb:PELI2(gene name)|psi-mi:PELI2(display_short)|uniprotkb:RING-type E3 ubiquitin transferase pellino homolog 2(gene name synonym)	psi-mi:ube2n_human(display_long)|uniprotkb:Ubiquitin-protein ligase N(gene name synonym)|uniprotkb:Ubiquitin carrier protein N(gene name synonym)|uniprotkb:Ubc13(gene name synonym)|uniprotkb:Bendless-like ubiquitin-conjugating enzyme(gene name synonym)|uniprotkb:UBE2N(gene name)|psi-mi:UBE2N(display_short)|uniprotkb:BLU(gene name synonym)|uniprotkb:UbcH13(gene name synonym)|uniprotkb:E2 ubiquitin-conjugating enzyme N(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9971107|imex:IM-22822-57	author-confidence:Z-score = 13.16	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067078.1|dip:DIP-31350N|ensembl:ENSG00000139946(gene)|ensembl:ENST00000267460(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0005829"(cytosol)|go:"GO:0008063"(Toll signaling pathway)|go:"GO:0008592"(regulation of Toll signaling pathway)|go:"GO:0034450"(ubiquitin-ubiquitin ligase activity)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0061630"(ubiquitin protein ligase activity)|interpro:IPR006800(Pellino)|mint:Q9HAT8|rcsb pdb:3EGA|rcsb pdb:3EGB|reactome:R-HSA-9020702|reactome:R-HSA-937039|reactome:R-HSA-975144	refseq:NP_003339.1|dip:DIP-29829N|ensembl:ENSG00000177889(gene)|ensembl:ENST00000318066(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000729"(DNA double-strand break processing)|go:"GO:0001650"(fibrillar center)|go:"GO:0003723"(RNA binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006282"(regulation of DNA repair)|go:"GO:0006301"(postreplication repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016574"(histone ubiquitination)|go:"GO:0031058"(positive regulation of histone modification)|go:"GO:0031372"(UBC13-MMS2 complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033182"(regulation of histone ubiquitination)|go:"GO:0035370"(UBC13-UEV1A complex)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0061631"(ubiquitin conjugating enzyme activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070534"(protein K63-linked ubiquitination)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|interpro:IPR023313|rcsb pdb:1J7D|rcsb pdb:2C2V|rcsb pdb:3HCT|rcsb pdb:3HCU|rcsb pdb:3VON|rcsb pdb:3W31|rcsb pdb:4DHI|rcsb pdb:4DHJ|rcsb pdb:4DHZ|rcsb pdb:4IP3|rcsb pdb:4NR3|rcsb pdb:4NRG|rcsb pdb:4NRI|rcsb pdb:4ONL|rcsb pdb:4ONM|rcsb pdb:4ONN|rcsb pdb:4ORH|rcsb pdb:4TKP|rcsb pdb:4WHV|rcsb pdb:5AIT|rcsb pdb:5AIU|rcsb pdb:5EYA|rcsb pdb:5H7S|rcsb pdb:5VNZ|rcsb pdb:5VO0|rcsb pdb:5YWR|rcsb pdb:6D6I|rcsb pdb:6JKY|rcsb pdb:6KFP|rcsb pdb:6KG6|rcsb pdb:6KL4|rcsb pdb:6LP2|rcsb pdb:6P5B|rcsb pdb:6S53|reactome:R-HSA-168927|reactome:R-HSA-202424|reactome:R-HSA-2871837|reactome:R-HSA-445989|reactome:R-HSA-450302|reactome:R-HSA-450321|reactome:R-HSA-5607764|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-5696395|reactome:R-HSA-69473|reactome:R-HSA-8866654|reactome:R-HSA-9020702|reactome:R-HSA-937039|reactome:R-HSA-937041|reactome:R-HSA-9646399|reactome:R-HSA-975110|reactome:R-HSA-975144|reactome:R-HSA-983168|rcsb pdb:6ULH|rcsb pdb:6UMP|rcsb pdb:6UMS|rcsb pdb:7BBD|rcsb pdb:7BBF|rcsb pdb:7BXG|reactome:R-HSA-1169408|reactome:R-HSA-168638	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S2|caution:"UBE2N has been marked as the enzyme in this assay, although it is the UBE2N-UBE2V1 complex that has ubiquitinase (E3) activity. Neither UBE2N nor UBE2V1 have E2 or E3 activity on their own."|resulting-ptm:Q9HAT8 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:Inw0l7txoS2SolLj5tAYnHd61Gs9606	rogid:dqdszHlq5FLPHC6UWX6uvkC6Yz89606	intact-crc:638236373570ED54|rigid:w/0bMr1w3rSrJ7cgnOaObOkto80	false	-	his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9H9V4	uniprotkb:Q13404	intact:EBI-2129998|uniprotkb:Q52LK3|ensembl:ENSP00000256257	intact:EBI-1050671|uniprotkb:Q13403|uniprotkb:Q13532|uniprotkb:Q96H34|uniprotkb:Q9GZT0|uniprotkb:Q9GZW1|uniprotkb:Q9H4J3|uniprotkb:Q9H4J4|uniprotkb:Q9UKL1|uniprotkb:Q9UM48|uniprotkb:Q9UM49|uniprotkb:Q9UM50|uniprotkb:Q5TGE3|uniprotkb:E1P629|uniprotkb:Q5TGE0|ensembl:ENSP00000360739	psi-mi:rn122_human(display_long)|uniprotkb:RNF122(gene name)|psi-mi:RNF122(display_short)	psi-mi:ub2v1_human(display_long)|uniprotkb:CROC-1(gene name synonym)|uniprotkb:TRAF6-regulated IKK activator 1 beta Uev1A(gene name synonym)|uniprotkb:P/OKcl.19(orf name)|uniprotkb:UBE2V1(gene name)|psi-mi:UBE2V1(display_short)|uniprotkb:CROC1(gene name synonym)|uniprotkb:UBE2V(gene name synonym)|uniprotkb:UEV1(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9971086|imex:IM-22822-56	author-confidence:Z-score = 3.64	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_079063.2|ensembl:ENSG00000133874(gene)|ensembl:ENST00000256257(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0010917"(negative regulation of mitochondrial membrane potential)|go:"GO:0012505"(endomembrane system)|go:"GO:0016021"(integral component of membrane)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0061630"(ubiquitin protein ligase activity)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)	refseq:NP_001027459.1|refseq:NP_068823.2|refseq:NP_071887.1|refseq:NP_954595.1|refseq:NP_954673.1|refseq:NP_001244322.1|refseq:NP_001244323.1|refseq:NP_001244325.1|ensembl:ENSG00000244687(gene)|ensembl:ENST00000371674(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006282"(regulation of DNA repair)|go:"GO:0006301"(postreplication repair)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0030154"(cell differentiation)|go:"GO:0031371"(ubiquitin conjugating enzyme complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035370"(UBC13-UEV1A complex)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070534"(protein K63-linked ubiquitination)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|rcsb pdb:2A4D|rcsb pdb:2C2V|rcsb pdb:2HLW|rcsb pdb:6D6I|reactome:R-HSA-168638|reactome:R-HSA-168927|reactome:R-HSA-202424|reactome:R-HSA-2871837|reactome:R-HSA-445989|reactome:R-HSA-450302|reactome:R-HSA-450321|reactome:R-HSA-5607764|reactome:R-HSA-9020702|reactome:R-HSA-937039|reactome:R-HSA-937041|reactome:R-HSA-9646399|reactome:R-HSA-975110|reactome:R-HSA-975144|reactome:R-HSA-983168|dip:DIP-41911N	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S2|caution:"UBE2N has been marked as the enzyme in this assay, although it is the UBE2N-UBE2V1 complex that has ubiquitinase (E3) activity. Neither UBE2N nor UBE2V1 have E2 or E3 activity on their own."|resulting-ptm:Q9H9V4 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:mNEF3wyRPfB1WyLpF+I27YBAqzQ9606	rogid:x95N7Dj2KIqu5gySX59xLmfthUg9606	intact-crc:9448A0123E567348|rigid:guZdBAzIlNyjJW3nWDYULDFJJic	false	-	his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9H9V4	uniprotkb:P22314	intact:EBI-2129998|uniprotkb:Q52LK3|ensembl:ENSP00000256257	intact:EBI-709688|uniprotkb:Q96E13|uniprotkb:Q5JRR8|ensembl:ENSP00000338413|ensembl:ENSP00000366568	psi-mi:rn122_human(display_long)|uniprotkb:RNF122(gene name)|psi-mi:RNF122(display_short)	psi-mi:uba1_human(display_long)|uniprotkb:Ubiquitin-activating enzyme E1(gene name synonym)|uniprotkb:Protein A1S9(gene name synonym)|uniprotkb:UBA1(gene name)|psi-mi:UBA1(display_short)|uniprotkb:A1S9T(gene name synonym)|uniprotkb:UBE1(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9971086|imex:IM-22822-56	author-confidence:Z-score = 3.64	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_079063.2|ensembl:ENSG00000133874(gene)|ensembl:ENST00000256257(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0010917"(negative regulation of mitochondrial membrane potential)|go:"GO:0012505"(endomembrane system)|go:"GO:0016021"(integral component of membrane)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0061630"(ubiquitin protein ligase activity)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)	refseq:NP_003325.2|refseq:NP_695012.1|refseq:XP_016885269.1|refseq:XP_016885270.1|dip:DIP-33686N|ensembl:ENSG00000130985(gene)|ensembl:ENST00000335972(transcript)|ensembl:ENST00000377351(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0004839"(ubiquitin activating enzyme activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0032446"(protein modification by small protein conjugation)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000011(Ubiquitin-activating enzyme, E1)|interpro:IPR000594(UBA/THIF-type NAD/FAD binding fold)|interpro:IPR018074|interpro:IPR018075|interpro:IPR018965|interpro:IPR019572|interpro:IPR032418|interpro:IPR032420|interpro:IPR033127|interpro:IPR035985|interpro:IPR038252|interpro:IPR042063|interpro:IPR042302|interpro:IPR042449|mint:P22314|rcsb pdb:4P22|rcsb pdb:6DC6|reactome:R-HSA-8866652|reactome:R-HSA-983168	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S2|caution:"UBE2N has been marked as the enzyme in this assay, although it is the UBE2N-UBE2V1 complex that has ubiquitinase (E3) activity. Neither UBE2N nor UBE2V1 have E2 or E3 activity on their own."|resulting-ptm:Q9H9V4 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:mNEF3wyRPfB1WyLpF+I27YBAqzQ9606	rogid:q+vEeA0XLST0Zz173bmEt0dNbDE9606	intact-crc:9448A0123E567348|rigid:guZdBAzIlNyjJW3nWDYULDFJJic	false	-	his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9H9V4	uniprotkb:P61088	intact:EBI-2129998|uniprotkb:Q52LK3|ensembl:ENSP00000256257	intact:EBI-1052908|uniprotkb:Q16781|uniprotkb:Q53Y81|ensembl:ENSP00000316176	psi-mi:rn122_human(display_long)|uniprotkb:RNF122(gene name)|psi-mi:RNF122(display_short)	psi-mi:ube2n_human(display_long)|uniprotkb:Ubiquitin-protein ligase N(gene name synonym)|uniprotkb:Ubiquitin carrier protein N(gene name synonym)|uniprotkb:Ubc13(gene name synonym)|uniprotkb:Bendless-like ubiquitin-conjugating enzyme(gene name synonym)|uniprotkb:UBE2N(gene name)|psi-mi:UBE2N(display_short)|uniprotkb:BLU(gene name synonym)|uniprotkb:UbcH13(gene name synonym)|uniprotkb:E2 ubiquitin-conjugating enzyme N(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9971086|imex:IM-22822-56	author-confidence:Z-score = 3.64	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_079063.2|ensembl:ENSG00000133874(gene)|ensembl:ENST00000256257(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0010917"(negative regulation of mitochondrial membrane potential)|go:"GO:0012505"(endomembrane system)|go:"GO:0016021"(integral component of membrane)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0061630"(ubiquitin protein ligase activity)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)	refseq:NP_003339.1|dip:DIP-29829N|ensembl:ENSG00000177889(gene)|ensembl:ENST00000318066(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000729"(DNA double-strand break processing)|go:"GO:0001650"(fibrillar center)|go:"GO:0003723"(RNA binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006282"(regulation of DNA repair)|go:"GO:0006301"(postreplication repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016574"(histone ubiquitination)|go:"GO:0031058"(positive regulation of histone modification)|go:"GO:0031372"(UBC13-MMS2 complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033182"(regulation of histone ubiquitination)|go:"GO:0035370"(UBC13-UEV1A complex)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0061631"(ubiquitin conjugating enzyme activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070534"(protein K63-linked ubiquitination)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|interpro:IPR023313|rcsb pdb:1J7D|rcsb pdb:2C2V|rcsb pdb:3HCT|rcsb pdb:3HCU|rcsb pdb:3VON|rcsb pdb:3W31|rcsb pdb:4DHI|rcsb pdb:4DHJ|rcsb pdb:4DHZ|rcsb pdb:4IP3|rcsb pdb:4NR3|rcsb pdb:4NRG|rcsb pdb:4NRI|rcsb pdb:4ONL|rcsb pdb:4ONM|rcsb pdb:4ONN|rcsb pdb:4ORH|rcsb pdb:4TKP|rcsb pdb:4WHV|rcsb pdb:5AIT|rcsb pdb:5AIU|rcsb pdb:5EYA|rcsb pdb:5H7S|rcsb pdb:5VNZ|rcsb pdb:5VO0|rcsb pdb:5YWR|rcsb pdb:6D6I|rcsb pdb:6JKY|rcsb pdb:6KFP|rcsb pdb:6KG6|rcsb pdb:6KL4|rcsb pdb:6LP2|rcsb pdb:6P5B|rcsb pdb:6S53|reactome:R-HSA-168927|reactome:R-HSA-202424|reactome:R-HSA-2871837|reactome:R-HSA-445989|reactome:R-HSA-450302|reactome:R-HSA-450321|reactome:R-HSA-5607764|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-5696395|reactome:R-HSA-69473|reactome:R-HSA-8866654|reactome:R-HSA-9020702|reactome:R-HSA-937039|reactome:R-HSA-937041|reactome:R-HSA-9646399|reactome:R-HSA-975110|reactome:R-HSA-975144|reactome:R-HSA-983168|rcsb pdb:6ULH|rcsb pdb:6UMP|rcsb pdb:6UMS|rcsb pdb:7BBD|rcsb pdb:7BBF|rcsb pdb:7BXG|reactome:R-HSA-1169408|reactome:R-HSA-168638	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S2|caution:"UBE2N has been marked as the enzyme in this assay, although it is the UBE2N-UBE2V1 complex that has ubiquitinase (E3) activity. Neither UBE2N nor UBE2V1 have E2 or E3 activity on their own."|resulting-ptm:Q9H9V4 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:mNEF3wyRPfB1WyLpF+I27YBAqzQ9606	rogid:dqdszHlq5FLPHC6UWX6uvkC6Yz89606	intact-crc:9448A0123E567348|rigid:guZdBAzIlNyjJW3nWDYULDFJJic	false	-	his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9HCE7	uniprotkb:Q13404	intact:EBI-976466|uniprotkb:O75853|uniprotkb:Q9UJT8|ensembl:ENSP00000354621|ensembl:ENSP00000492201|uniprotkb:B7ZMB6|uniprotkb:B9EGV3|uniprotkb:Q547Q3|uniprotkb:A4D279	intact:EBI-1050671|uniprotkb:Q13403|uniprotkb:Q13532|uniprotkb:Q96H34|uniprotkb:Q9GZT0|uniprotkb:Q9GZW1|uniprotkb:Q9H4J3|uniprotkb:Q9H4J4|uniprotkb:Q9UKL1|uniprotkb:Q9UM48|uniprotkb:Q9UM49|uniprotkb:Q9UM50|uniprotkb:Q5TGE3|uniprotkb:E1P629|uniprotkb:Q5TGE0|ensembl:ENSP00000360739	psi-mi:smuf1_human(display_long)|uniprotkb:SMAD ubiquitination regulatory factor 1(gene name synonym)|uniprotkb:SMAD-specific E3 ubiquitin-protein ligase 1(gene name synonym)|uniprotkb:SMURF1(gene name)|psi-mi:SMURF1(display_short)|uniprotkb:KIAA1625(gene name synonym)|uniprotkb:HECT-type E3 ubiquitin transferase SMURF1(gene name synonym)	psi-mi:ub2v1_human(display_long)|uniprotkb:CROC-1(gene name synonym)|uniprotkb:TRAF6-regulated IKK activator 1 beta Uev1A(gene name synonym)|uniprotkb:P/OKcl.19(orf name)|uniprotkb:UBE2V1(gene name)|psi-mi:UBE2V1(display_short)|uniprotkb:CROC1(gene name synonym)|uniprotkb:UBE2V(gene name synonym)|uniprotkb:UEV1(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9971128|imex:IM-22822-58	author-confidence:Z-score = 3.33	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000198742(gene)|ensembl:ENSG00000284126(gene)|ensembl:ENST00000361125(transcript)|ensembl:ENST00000638647(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006611"(protein export from nucleus)|go:"GO:0007398"(ectoderm development)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0030579"(ubiquitin-dependent SMAD protein catabolic process)|go:"GO:0032801"(receptor catabolic process)|go:"GO:0034394"(protein localization to cell surface)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0048185"(activin binding)|go:"GO:0060071"(Wnt signaling pathway, planar cell polarity pathway)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0061736"(engulfment of target by autophagosome)|go:"GO:0061753"(substrate localization to autophagosome)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070411"(I-SMAD binding)|go:"GO:0070412"(R-SMAD binding)|go:"GO:0071211"(protein targeting to vacuole involved in autophagy)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:1903861"(positive regulation of dendrite extension)|go:"GO:2000060"(positive regulation of ubiquitin-dependent protein catabolic process)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000569(HECT)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR024928|interpro:IPR035892|interpro:IPR035983|interpro:IPR036020|mint:Q9HCE7|rcsb pdb:2LB0|rcsb pdb:2LB1|rcsb pdb:2LTX|rcsb pdb:3PYC|reactome:R-HSA-201451|reactome:R-HSA-2173788|reactome:R-HSA-2173791|reactome:R-HSA-4608870|reactome:R-HSA-5632684|reactome:R-HSA-8939902|reactome:R-HSA-8941858|reactome:R-HSA-983168|rcsb pdb:2LAZ|refseq:NP_065162.1|refseq:NP_851994.1|refseq:NP_001186776.1|dip:DIP-36709N	refseq:NP_001027459.1|refseq:NP_068823.2|refseq:NP_071887.1|refseq:NP_954595.1|refseq:NP_954673.1|refseq:NP_001244322.1|refseq:NP_001244323.1|refseq:NP_001244325.1|ensembl:ENSG00000244687(gene)|ensembl:ENST00000371674(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006282"(regulation of DNA repair)|go:"GO:0006301"(postreplication repair)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0030154"(cell differentiation)|go:"GO:0031371"(ubiquitin conjugating enzyme complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035370"(UBC13-UEV1A complex)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070534"(protein K63-linked ubiquitination)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|rcsb pdb:2A4D|rcsb pdb:2C2V|rcsb pdb:2HLW|rcsb pdb:6D6I|reactome:R-HSA-168638|reactome:R-HSA-168927|reactome:R-HSA-202424|reactome:R-HSA-2871837|reactome:R-HSA-445989|reactome:R-HSA-450302|reactome:R-HSA-450321|reactome:R-HSA-5607764|reactome:R-HSA-9020702|reactome:R-HSA-937039|reactome:R-HSA-937041|reactome:R-HSA-9646399|reactome:R-HSA-975110|reactome:R-HSA-975144|reactome:R-HSA-983168|dip:DIP-41911N	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S2|caution:"UBE2N has been marked as the enzyme in this assay, although it is the UBE2N-UBE2V1 complex that has ubiquitinase (E3) activity. Neither UBE2N nor UBE2V1 have E2 or E3 activity on their own."|resulting-ptm:Q9HCE7 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:WFypGZd4qJom//+gDWfxmzjDG6M9606	rogid:x95N7Dj2KIqu5gySX59xLmfthUg9606	intact-crc:3E80EE566C1E34A9|rigid:h8nw5TV4nbGuvX31P1pR/Nq7vDk	false	-	his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9HCE7	uniprotkb:P22314	intact:EBI-976466|uniprotkb:O75853|uniprotkb:Q9UJT8|ensembl:ENSP00000354621|ensembl:ENSP00000492201|uniprotkb:B7ZMB6|uniprotkb:B9EGV3|uniprotkb:Q547Q3|uniprotkb:A4D279	intact:EBI-709688|uniprotkb:Q96E13|uniprotkb:Q5JRR8|ensembl:ENSP00000338413|ensembl:ENSP00000366568	psi-mi:smuf1_human(display_long)|uniprotkb:SMAD ubiquitination regulatory factor 1(gene name synonym)|uniprotkb:SMAD-specific E3 ubiquitin-protein ligase 1(gene name synonym)|uniprotkb:SMURF1(gene name)|psi-mi:SMURF1(display_short)|uniprotkb:KIAA1625(gene name synonym)|uniprotkb:HECT-type E3 ubiquitin transferase SMURF1(gene name synonym)	psi-mi:uba1_human(display_long)|uniprotkb:Ubiquitin-activating enzyme E1(gene name synonym)|uniprotkb:Protein A1S9(gene name synonym)|uniprotkb:UBA1(gene name)|psi-mi:UBA1(display_short)|uniprotkb:A1S9T(gene name synonym)|uniprotkb:UBE1(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9971128|imex:IM-22822-58	author-confidence:Z-score = 3.33	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000198742(gene)|ensembl:ENSG00000284126(gene)|ensembl:ENST00000361125(transcript)|ensembl:ENST00000638647(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006611"(protein export from nucleus)|go:"GO:0007398"(ectoderm development)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0030579"(ubiquitin-dependent SMAD protein catabolic process)|go:"GO:0032801"(receptor catabolic process)|go:"GO:0034394"(protein localization to cell surface)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0048185"(activin binding)|go:"GO:0060071"(Wnt signaling pathway, planar cell polarity pathway)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0061736"(engulfment of target by autophagosome)|go:"GO:0061753"(substrate localization to autophagosome)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070411"(I-SMAD binding)|go:"GO:0070412"(R-SMAD binding)|go:"GO:0071211"(protein targeting to vacuole involved in autophagy)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:1903861"(positive regulation of dendrite extension)|go:"GO:2000060"(positive regulation of ubiquitin-dependent protein catabolic process)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000569(HECT)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR024928|interpro:IPR035892|interpro:IPR035983|interpro:IPR036020|mint:Q9HCE7|rcsb pdb:2LB0|rcsb pdb:2LB1|rcsb pdb:2LTX|rcsb pdb:3PYC|reactome:R-HSA-201451|reactome:R-HSA-2173788|reactome:R-HSA-2173791|reactome:R-HSA-4608870|reactome:R-HSA-5632684|reactome:R-HSA-8939902|reactome:R-HSA-8941858|reactome:R-HSA-983168|rcsb pdb:2LAZ|refseq:NP_065162.1|refseq:NP_851994.1|refseq:NP_001186776.1|dip:DIP-36709N	refseq:NP_003325.2|refseq:NP_695012.1|refseq:XP_016885269.1|refseq:XP_016885270.1|dip:DIP-33686N|ensembl:ENSG00000130985(gene)|ensembl:ENST00000335972(transcript)|ensembl:ENST00000377351(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0004839"(ubiquitin activating enzyme activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0032446"(protein modification by small protein conjugation)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000011(Ubiquitin-activating enzyme, E1)|interpro:IPR000594(UBA/THIF-type NAD/FAD binding fold)|interpro:IPR018074|interpro:IPR018075|interpro:IPR018965|interpro:IPR019572|interpro:IPR032418|interpro:IPR032420|interpro:IPR033127|interpro:IPR035985|interpro:IPR038252|interpro:IPR042063|interpro:IPR042302|interpro:IPR042449|mint:P22314|rcsb pdb:4P22|rcsb pdb:6DC6|reactome:R-HSA-8866652|reactome:R-HSA-983168	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S2|caution:"UBE2N has been marked as the enzyme in this assay, although it is the UBE2N-UBE2V1 complex that has ubiquitinase (E3) activity. Neither UBE2N nor UBE2V1 have E2 or E3 activity on their own."|resulting-ptm:Q9HCE7 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:WFypGZd4qJom//+gDWfxmzjDG6M9606	rogid:q+vEeA0XLST0Zz173bmEt0dNbDE9606	intact-crc:3E80EE566C1E34A9|rigid:h8nw5TV4nbGuvX31P1pR/Nq7vDk	false	-	his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9HCE7	uniprotkb:P61088	intact:EBI-976466|uniprotkb:O75853|uniprotkb:Q9UJT8|ensembl:ENSP00000354621|ensembl:ENSP00000492201|uniprotkb:B7ZMB6|uniprotkb:B9EGV3|uniprotkb:Q547Q3|uniprotkb:A4D279	intact:EBI-1052908|uniprotkb:Q16781|uniprotkb:Q53Y81|ensembl:ENSP00000316176	psi-mi:smuf1_human(display_long)|uniprotkb:SMAD ubiquitination regulatory factor 1(gene name synonym)|uniprotkb:SMAD-specific E3 ubiquitin-protein ligase 1(gene name synonym)|uniprotkb:SMURF1(gene name)|psi-mi:SMURF1(display_short)|uniprotkb:KIAA1625(gene name synonym)|uniprotkb:HECT-type E3 ubiquitin transferase SMURF1(gene name synonym)	psi-mi:ube2n_human(display_long)|uniprotkb:Ubiquitin-protein ligase N(gene name synonym)|uniprotkb:Ubiquitin carrier protein N(gene name synonym)|uniprotkb:Ubc13(gene name synonym)|uniprotkb:Bendless-like ubiquitin-conjugating enzyme(gene name synonym)|uniprotkb:UBE2N(gene name)|psi-mi:UBE2N(display_short)|uniprotkb:BLU(gene name synonym)|uniprotkb:UbcH13(gene name synonym)|uniprotkb:E2 ubiquitin-conjugating enzyme N(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9971128|imex:IM-22822-58	author-confidence:Z-score = 3.33	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000198742(gene)|ensembl:ENSG00000284126(gene)|ensembl:ENST00000361125(transcript)|ensembl:ENST00000638647(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006611"(protein export from nucleus)|go:"GO:0007398"(ectoderm development)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0030579"(ubiquitin-dependent SMAD protein catabolic process)|go:"GO:0032801"(receptor catabolic process)|go:"GO:0034394"(protein localization to cell surface)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0048185"(activin binding)|go:"GO:0060071"(Wnt signaling pathway, planar cell polarity pathway)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0061736"(engulfment of target by autophagosome)|go:"GO:0061753"(substrate localization to autophagosome)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070411"(I-SMAD binding)|go:"GO:0070412"(R-SMAD binding)|go:"GO:0071211"(protein targeting to vacuole involved in autophagy)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:1903861"(positive regulation of dendrite extension)|go:"GO:2000060"(positive regulation of ubiquitin-dependent protein catabolic process)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000569(HECT)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR024928|interpro:IPR035892|interpro:IPR035983|interpro:IPR036020|mint:Q9HCE7|rcsb pdb:2LB0|rcsb pdb:2LB1|rcsb pdb:2LTX|rcsb pdb:3PYC|reactome:R-HSA-201451|reactome:R-HSA-2173788|reactome:R-HSA-2173791|reactome:R-HSA-4608870|reactome:R-HSA-5632684|reactome:R-HSA-8939902|reactome:R-HSA-8941858|reactome:R-HSA-983168|rcsb pdb:2LAZ|refseq:NP_065162.1|refseq:NP_851994.1|refseq:NP_001186776.1|dip:DIP-36709N	refseq:NP_003339.1|dip:DIP-29829N|ensembl:ENSG00000177889(gene)|ensembl:ENST00000318066(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000729"(DNA double-strand break processing)|go:"GO:0001650"(fibrillar center)|go:"GO:0003723"(RNA binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006282"(regulation of DNA repair)|go:"GO:0006301"(postreplication repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016574"(histone ubiquitination)|go:"GO:0031058"(positive regulation of histone modification)|go:"GO:0031372"(UBC13-MMS2 complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033182"(regulation of histone ubiquitination)|go:"GO:0035370"(UBC13-UEV1A complex)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0061631"(ubiquitin conjugating enzyme activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070534"(protein K63-linked ubiquitination)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|interpro:IPR023313|rcsb pdb:1J7D|rcsb pdb:2C2V|rcsb pdb:3HCT|rcsb pdb:3HCU|rcsb pdb:3VON|rcsb pdb:3W31|rcsb pdb:4DHI|rcsb pdb:4DHJ|rcsb pdb:4DHZ|rcsb pdb:4IP3|rcsb pdb:4NR3|rcsb pdb:4NRG|rcsb pdb:4NRI|rcsb pdb:4ONL|rcsb pdb:4ONM|rcsb pdb:4ONN|rcsb pdb:4ORH|rcsb pdb:4TKP|rcsb pdb:4WHV|rcsb pdb:5AIT|rcsb pdb:5AIU|rcsb pdb:5EYA|rcsb pdb:5H7S|rcsb pdb:5VNZ|rcsb pdb:5VO0|rcsb pdb:5YWR|rcsb pdb:6D6I|rcsb pdb:6JKY|rcsb pdb:6KFP|rcsb pdb:6KG6|rcsb pdb:6KL4|rcsb pdb:6LP2|rcsb pdb:6P5B|rcsb pdb:6S53|reactome:R-HSA-168927|reactome:R-HSA-202424|reactome:R-HSA-2871837|reactome:R-HSA-445989|reactome:R-HSA-450302|reactome:R-HSA-450321|reactome:R-HSA-5607764|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-5696395|reactome:R-HSA-69473|reactome:R-HSA-8866654|reactome:R-HSA-9020702|reactome:R-HSA-937039|reactome:R-HSA-937041|reactome:R-HSA-9646399|reactome:R-HSA-975110|reactome:R-HSA-975144|reactome:R-HSA-983168|rcsb pdb:6ULH|rcsb pdb:6UMP|rcsb pdb:6UMS|rcsb pdb:7BBD|rcsb pdb:7BBF|rcsb pdb:7BXG|reactome:R-HSA-1169408|reactome:R-HSA-168638	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S2|caution:"UBE2N has been marked as the enzyme in this assay, although it is the UBE2N-UBE2V1 complex that has ubiquitinase (E3) activity. Neither UBE2N nor UBE2V1 have E2 or E3 activity on their own."|resulting-ptm:Q9HCE7 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:WFypGZd4qJom//+gDWfxmzjDG6M9606	rogid:dqdszHlq5FLPHC6UWX6uvkC6Yz89606	intact-crc:3E80EE566C1E34A9|rigid:h8nw5TV4nbGuvX31P1pR/Nq7vDk	false	-	his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q13404	uniprotkb:P22314	intact:EBI-1050671|uniprotkb:Q13403|uniprotkb:Q13532|uniprotkb:Q96H34|uniprotkb:Q9GZT0|uniprotkb:Q9GZW1|uniprotkb:Q9H4J3|uniprotkb:Q9H4J4|uniprotkb:Q9UKL1|uniprotkb:Q9UM48|uniprotkb:Q9UM49|uniprotkb:Q9UM50|uniprotkb:Q5TGE3|uniprotkb:E1P629|uniprotkb:Q5TGE0|ensembl:ENSP00000360739	intact:EBI-709688|uniprotkb:Q96E13|uniprotkb:Q5JRR8|ensembl:ENSP00000338413|ensembl:ENSP00000366568	psi-mi:ub2v1_human(display_long)|uniprotkb:CROC-1(gene name synonym)|uniprotkb:TRAF6-regulated IKK activator 1 beta Uev1A(gene name synonym)|uniprotkb:P/OKcl.19(orf name)|uniprotkb:UBE2V1(gene name)|psi-mi:UBE2V1(display_short)|uniprotkb:CROC1(gene name synonym)|uniprotkb:UBE2V(gene name synonym)|uniprotkb:UEV1(gene name synonym)	psi-mi:uba1_human(display_long)|uniprotkb:Ubiquitin-activating enzyme E1(gene name synonym)|uniprotkb:Protein A1S9(gene name synonym)|uniprotkb:UBA1(gene name)|psi-mi:UBA1(display_short)|uniprotkb:A1S9T(gene name synonym)|uniprotkb:UBE1(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9971149|imex:IM-22822-59	author-confidence:Z-score = 7.28	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001027459.1|refseq:NP_068823.2|refseq:NP_071887.1|refseq:NP_954595.1|refseq:NP_954673.1|refseq:NP_001244322.1|refseq:NP_001244323.1|refseq:NP_001244325.1|ensembl:ENSG00000244687(gene)|ensembl:ENST00000371674(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006282"(regulation of DNA repair)|go:"GO:0006301"(postreplication repair)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0030154"(cell differentiation)|go:"GO:0031371"(ubiquitin conjugating enzyme complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035370"(UBC13-UEV1A complex)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070534"(protein K63-linked ubiquitination)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|rcsb pdb:2A4D|rcsb pdb:2C2V|rcsb pdb:2HLW|rcsb pdb:6D6I|reactome:R-HSA-168638|reactome:R-HSA-168927|reactome:R-HSA-202424|reactome:R-HSA-2871837|reactome:R-HSA-445989|reactome:R-HSA-450302|reactome:R-HSA-450321|reactome:R-HSA-5607764|reactome:R-HSA-9020702|reactome:R-HSA-937039|reactome:R-HSA-937041|reactome:R-HSA-9646399|reactome:R-HSA-975110|reactome:R-HSA-975144|reactome:R-HSA-983168|dip:DIP-41911N	refseq:NP_003325.2|refseq:NP_695012.1|refseq:XP_016885269.1|refseq:XP_016885270.1|dip:DIP-33686N|ensembl:ENSG00000130985(gene)|ensembl:ENST00000335972(transcript)|ensembl:ENST00000377351(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0004839"(ubiquitin activating enzyme activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0032446"(protein modification by small protein conjugation)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000011(Ubiquitin-activating enzyme, E1)|interpro:IPR000594(UBA/THIF-type NAD/FAD binding fold)|interpro:IPR018074|interpro:IPR018075|interpro:IPR018965|interpro:IPR019572|interpro:IPR032418|interpro:IPR032420|interpro:IPR033127|interpro:IPR035985|interpro:IPR038252|interpro:IPR042063|interpro:IPR042302|interpro:IPR042449|mint:P22314|rcsb pdb:4P22|rcsb pdb:6DC6|reactome:R-HSA-8866652|reactome:R-HSA-983168	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S2|caution:"UBE2N has been marked as the enzyme in this assay, although it is the UBE2N-UBE2V1 complex that has ubiquitinase (E3) activity. Neither UBE2N nor UBE2V1 have E2 or E3 activity on their own."|resulting-ptm:Q9NPD8 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:x95N7Dj2KIqu5gySX59xLmfthUg9606	rogid:q+vEeA0XLST0Zz173bmEt0dNbDE9606	intact-crc:B4B650A8D8135452|rigid:3wnEXmYmn4KVdVDSIDCwIUCrI9k	false	his tag:?-?	his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q13404	uniprotkb:P61088	intact:EBI-1050671|uniprotkb:Q13403|uniprotkb:Q13532|uniprotkb:Q96H34|uniprotkb:Q9GZT0|uniprotkb:Q9GZW1|uniprotkb:Q9H4J3|uniprotkb:Q9H4J4|uniprotkb:Q9UKL1|uniprotkb:Q9UM48|uniprotkb:Q9UM49|uniprotkb:Q9UM50|uniprotkb:Q5TGE3|uniprotkb:E1P629|uniprotkb:Q5TGE0|ensembl:ENSP00000360739	intact:EBI-1052908|uniprotkb:Q16781|uniprotkb:Q53Y81|ensembl:ENSP00000316176	psi-mi:ub2v1_human(display_long)|uniprotkb:CROC-1(gene name synonym)|uniprotkb:TRAF6-regulated IKK activator 1 beta Uev1A(gene name synonym)|uniprotkb:P/OKcl.19(orf name)|uniprotkb:UBE2V1(gene name)|psi-mi:UBE2V1(display_short)|uniprotkb:CROC1(gene name synonym)|uniprotkb:UBE2V(gene name synonym)|uniprotkb:UEV1(gene name synonym)	psi-mi:ube2n_human(display_long)|uniprotkb:Ubiquitin-protein ligase N(gene name synonym)|uniprotkb:Ubiquitin carrier protein N(gene name synonym)|uniprotkb:Ubc13(gene name synonym)|uniprotkb:Bendless-like ubiquitin-conjugating enzyme(gene name synonym)|uniprotkb:UBE2N(gene name)|psi-mi:UBE2N(display_short)|uniprotkb:BLU(gene name synonym)|uniprotkb:UbcH13(gene name synonym)|uniprotkb:E2 ubiquitin-conjugating enzyme N(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9971149|imex:IM-22822-59	author-confidence:Z-score = 7.28	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001027459.1|refseq:NP_068823.2|refseq:NP_071887.1|refseq:NP_954595.1|refseq:NP_954673.1|refseq:NP_001244322.1|refseq:NP_001244323.1|refseq:NP_001244325.1|ensembl:ENSG00000244687(gene)|ensembl:ENST00000371674(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006282"(regulation of DNA repair)|go:"GO:0006301"(postreplication repair)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0030154"(cell differentiation)|go:"GO:0031371"(ubiquitin conjugating enzyme complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035370"(UBC13-UEV1A complex)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070534"(protein K63-linked ubiquitination)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|rcsb pdb:2A4D|rcsb pdb:2C2V|rcsb pdb:2HLW|rcsb pdb:6D6I|reactome:R-HSA-168638|reactome:R-HSA-168927|reactome:R-HSA-202424|reactome:R-HSA-2871837|reactome:R-HSA-445989|reactome:R-HSA-450302|reactome:R-HSA-450321|reactome:R-HSA-5607764|reactome:R-HSA-9020702|reactome:R-HSA-937039|reactome:R-HSA-937041|reactome:R-HSA-9646399|reactome:R-HSA-975110|reactome:R-HSA-975144|reactome:R-HSA-983168|dip:DIP-41911N	refseq:NP_003339.1|dip:DIP-29829N|ensembl:ENSG00000177889(gene)|ensembl:ENST00000318066(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000729"(DNA double-strand break processing)|go:"GO:0001650"(fibrillar center)|go:"GO:0003723"(RNA binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006282"(regulation of DNA repair)|go:"GO:0006301"(postreplication repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016574"(histone ubiquitination)|go:"GO:0031058"(positive regulation of histone modification)|go:"GO:0031372"(UBC13-MMS2 complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033182"(regulation of histone ubiquitination)|go:"GO:0035370"(UBC13-UEV1A complex)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0061631"(ubiquitin conjugating enzyme activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070534"(protein K63-linked ubiquitination)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|interpro:IPR023313|rcsb pdb:1J7D|rcsb pdb:2C2V|rcsb pdb:3HCT|rcsb pdb:3HCU|rcsb pdb:3VON|rcsb pdb:3W31|rcsb pdb:4DHI|rcsb pdb:4DHJ|rcsb pdb:4DHZ|rcsb pdb:4IP3|rcsb pdb:4NR3|rcsb pdb:4NRG|rcsb pdb:4NRI|rcsb pdb:4ONL|rcsb pdb:4ONM|rcsb pdb:4ONN|rcsb pdb:4ORH|rcsb pdb:4TKP|rcsb pdb:4WHV|rcsb pdb:5AIT|rcsb pdb:5AIU|rcsb pdb:5EYA|rcsb pdb:5H7S|rcsb pdb:5VNZ|rcsb pdb:5VO0|rcsb pdb:5YWR|rcsb pdb:6D6I|rcsb pdb:6JKY|rcsb pdb:6KFP|rcsb pdb:6KG6|rcsb pdb:6KL4|rcsb pdb:6LP2|rcsb pdb:6P5B|rcsb pdb:6S53|reactome:R-HSA-168927|reactome:R-HSA-202424|reactome:R-HSA-2871837|reactome:R-HSA-445989|reactome:R-HSA-450302|reactome:R-HSA-450321|reactome:R-HSA-5607764|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-5696395|reactome:R-HSA-69473|reactome:R-HSA-8866654|reactome:R-HSA-9020702|reactome:R-HSA-937039|reactome:R-HSA-937041|reactome:R-HSA-9646399|reactome:R-HSA-975110|reactome:R-HSA-975144|reactome:R-HSA-983168|rcsb pdb:6ULH|rcsb pdb:6UMP|rcsb pdb:6UMS|rcsb pdb:7BBD|rcsb pdb:7BBF|rcsb pdb:7BXG|reactome:R-HSA-1169408|reactome:R-HSA-168638	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S2|caution:"UBE2N has been marked as the enzyme in this assay, although it is the UBE2N-UBE2V1 complex that has ubiquitinase (E3) activity. Neither UBE2N nor UBE2V1 have E2 or E3 activity on their own."|resulting-ptm:Q9NPD8 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:x95N7Dj2KIqu5gySX59xLmfthUg9606	rogid:dqdszHlq5FLPHC6UWX6uvkC6Yz89606	intact-crc:B4B650A8D8135452|rigid:3wnEXmYmn4KVdVDSIDCwIUCrI9k	false	his tag:?-?	his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q13404	uniprotkb:Q9NPD8	intact:EBI-1050671|uniprotkb:Q13403|uniprotkb:Q13532|uniprotkb:Q96H34|uniprotkb:Q9GZT0|uniprotkb:Q9GZW1|uniprotkb:Q9H4J3|uniprotkb:Q9H4J4|uniprotkb:Q9UKL1|uniprotkb:Q9UM48|uniprotkb:Q9UM49|uniprotkb:Q9UM50|uniprotkb:Q5TGE3|uniprotkb:E1P629|uniprotkb:Q5TGE0|ensembl:ENSP00000360739	intact:EBI-2130165|uniprotkb:Q2TU36|ensembl:ENSP00000494957	psi-mi:ub2v1_human(display_long)|uniprotkb:CROC-1(gene name synonym)|uniprotkb:TRAF6-regulated IKK activator 1 beta Uev1A(gene name synonym)|uniprotkb:P/OKcl.19(orf name)|uniprotkb:UBE2V1(gene name)|psi-mi:UBE2V1(display_short)|uniprotkb:CROC1(gene name synonym)|uniprotkb:UBE2V(gene name synonym)|uniprotkb:UEV1(gene name synonym)	psi-mi:ube2t_human(display_long)|uniprotkb:UBE2T(gene name)|psi-mi:UBE2T(display_short)|uniprotkb:Ubiquitin-protein ligase T(gene name synonym)|uniprotkb:Ubiquitin carrier protein T(gene name synonym)|uniprotkb:HSPC150(orf name)|uniprotkb:Cell proliferation-inducing gene 50 protein(gene name synonym)|uniprotkb:PIG50(orf name)|uniprotkb:E2 ubiquitin-conjugating enzyme T(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9971149|imex:IM-22822-59	author-confidence:Z-score = 7.28	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001027459.1|refseq:NP_068823.2|refseq:NP_071887.1|refseq:NP_954595.1|refseq:NP_954673.1|refseq:NP_001244322.1|refseq:NP_001244323.1|refseq:NP_001244325.1|ensembl:ENSG00000244687(gene)|ensembl:ENST00000371674(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006282"(regulation of DNA repair)|go:"GO:0006301"(postreplication repair)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0030154"(cell differentiation)|go:"GO:0031371"(ubiquitin conjugating enzyme complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035370"(UBC13-UEV1A complex)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070534"(protein K63-linked ubiquitination)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|rcsb pdb:2A4D|rcsb pdb:2C2V|rcsb pdb:2HLW|rcsb pdb:6D6I|reactome:R-HSA-168638|reactome:R-HSA-168927|reactome:R-HSA-202424|reactome:R-HSA-2871837|reactome:R-HSA-445989|reactome:R-HSA-450302|reactome:R-HSA-450321|reactome:R-HSA-5607764|reactome:R-HSA-9020702|reactome:R-HSA-937039|reactome:R-HSA-937041|reactome:R-HSA-9646399|reactome:R-HSA-975110|reactome:R-HSA-975144|reactome:R-HSA-983168|dip:DIP-41911N	refseq:NP_054895.1|refseq:NP_001297255.1|dip:DIP-52740N|ensembl:ENSG00000077152(gene)|ensembl:ENST00000646651(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0003682"(chromatin binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006281"(DNA repair)|go:"GO:0006513"(protein monoubiquitination)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0035519"(protein K29-linked ubiquitination)|go:"GO:0044314"(protein K27-linked ubiquitination)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0061631"(ubiquitin conjugating enzyme activity)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0070936"(protein K48-linked ubiquitination)|go:"GO:0070979"(protein K11-linked ubiquitination)|go:"GO:0085020"(protein K6-linked ubiquitination)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|interpro:IPR023313|rcsb pdb:1YH2|rcsb pdb:4CCG|rcsb pdb:5NGZ|rcsb pdb:5OJJ|rcsb pdb:6R75|rcsb pdb:7KZR|rcsb pdb:7KZS|rcsb pdb:7KZT|rcsb pdb:7KZV|reactome:R-HSA-6783310|reactome:R-HSA-8866652	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S2|caution:"UBE2N has been marked as the enzyme in this assay, although it is the UBE2N-UBE2V1 complex that has ubiquitinase (E3) activity. Neither UBE2N nor UBE2V1 have E2 or E3 activity on their own."|resulting-ptm:Q9NPD8 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:x95N7Dj2KIqu5gySX59xLmfthUg9606	rogid:hKFqKCWzIhcGshB1ut+mTTSwxbQ9606	intact-crc:B4B650A8D8135452|rigid:3wnEXmYmn4KVdVDSIDCwIUCrI9k	false	his tag:?-?	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9UNE7	uniprotkb:Q13404	intact:EBI-357085|uniprotkb:O60526|uniprotkb:Q969U2|uniprotkb:Q9HBT1|uniprotkb:A2IDB9|ensembl:ENSP00000219548	intact:EBI-1050671|uniprotkb:Q13403|uniprotkb:Q13532|uniprotkb:Q96H34|uniprotkb:Q9GZT0|uniprotkb:Q9GZW1|uniprotkb:Q9H4J3|uniprotkb:Q9H4J4|uniprotkb:Q9UKL1|uniprotkb:Q9UM48|uniprotkb:Q9UM49|uniprotkb:Q9UM50|uniprotkb:Q5TGE3|uniprotkb:E1P629|uniprotkb:Q5TGE0|ensembl:ENSP00000360739	psi-mi:chip_human(display_long)|uniprotkb:CHIP(gene name synonym)|uniprotkb:STUB1(gene name)|psi-mi:STUB1(display_short)|uniprotkb:PP1131(orf name)|uniprotkb:Carboxy terminus of Hsp70-interacting protein(gene name synonym)|uniprotkb:STIP1 homology and U box-containing protein 1(gene name synonym)|uniprotkb:CLL-associated antigen KW-8(gene name synonym)|uniprotkb:Antigen NY-CO-7(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase CHIP(gene name synonym)	psi-mi:ub2v1_human(display_long)|uniprotkb:CROC-1(gene name synonym)|uniprotkb:TRAF6-regulated IKK activator 1 beta Uev1A(gene name synonym)|uniprotkb:P/OKcl.19(orf name)|uniprotkb:UBE2V1(gene name)|psi-mi:UBE2V1(display_short)|uniprotkb:CROC1(gene name synonym)|uniprotkb:UBE2V(gene name synonym)|uniprotkb:UEV1(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9971212|imex:IM-22822-62	author-confidence:Z-score = 18.62	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	dip:DIP-29752N|refseq:NP_005852.2|refseq:NP_001280126.1|ensembl:ENSG00000103266(gene)|ensembl:ENST00000219548(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0002931"(response to ischemia)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006515"(protein quality control for misfolded or incompletely synthesized proteins)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019899"(enzyme binding)|go:"GO:0019900"(kinase binding)|go:"GO:0030018"(Z disc)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030911"(TPR domain binding)|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031371"(ubiquitin conjugating enzyme complex)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031943"(regulation of glucocorticoid metabolic process)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0034450"(ubiquitin-ubiquitin ligase activity)|go:"GO:0034605"(cellular response to heat)|go:"GO:0038128"(ERBB2 signaling pathway)|go:"GO:0042405"(nuclear inclusion body)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045862"(positive regulation of proteolysis)|go:"GO:0046332"(SMAD binding)|go:"GO:0048156"(tau protein binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0051604"(protein maturation)|go:"GO:0051787"(misfolded protein binding)|go:"GO:0030579"(ubiquitin-dependent SMAD protein catabolic process)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0061684"(chaperone-mediated autophagy)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0071218"(cellular response to misfolded protein)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0090035"(positive regulation of chaperone-mediated protein complex assembly)|go:"GO:0101031"(chaperone complex)|interpro:IPR003613(U box)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR019734|interpro:IPR041312|mint:Q9UNE7|rcsb pdb:4KBQ|rcsb pdb:6EFK|rcsb pdb:6NSV|reactome:R-HSA-2173788|reactome:R-HSA-5213460|reactome:R-HSA-5675482|reactome:R-HSA-8863795|reactome:R-HSA-8939902|reactome:R-HSA-8948751|reactome:R-HSA-983168	refseq:NP_001027459.1|refseq:NP_068823.2|refseq:NP_071887.1|refseq:NP_954595.1|refseq:NP_954673.1|refseq:NP_001244322.1|refseq:NP_001244323.1|refseq:NP_001244325.1|ensembl:ENSG00000244687(gene)|ensembl:ENST00000371674(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006282"(regulation of DNA repair)|go:"GO:0006301"(postreplication repair)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0030154"(cell differentiation)|go:"GO:0031371"(ubiquitin conjugating enzyme complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035370"(UBC13-UEV1A complex)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070534"(protein K63-linked ubiquitination)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|rcsb pdb:2A4D|rcsb pdb:2C2V|rcsb pdb:2HLW|rcsb pdb:6D6I|reactome:R-HSA-168638|reactome:R-HSA-168927|reactome:R-HSA-202424|reactome:R-HSA-2871837|reactome:R-HSA-445989|reactome:R-HSA-450302|reactome:R-HSA-450321|reactome:R-HSA-5607764|reactome:R-HSA-9020702|reactome:R-HSA-937039|reactome:R-HSA-937041|reactome:R-HSA-9646399|reactome:R-HSA-975110|reactome:R-HSA-975144|reactome:R-HSA-983168|dip:DIP-41911N	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S2|caution:"UBE2N has been marked as the enzyme in this assay, although it is the UBE2N-UBE2V1 complex that has ubiquitinase (E3) activity. Neither UBE2N nor UBE2V1 have E2 or E3 activity on their own."|resulting-ptm:Q9UNE7 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:h4QyIM0TptgkQppPUgiKn68XjP49606	rogid:x95N7Dj2KIqu5gySX59xLmfthUg9606	intact-crc:7AE4130DC911D703|rigid:O+267gHrEqc1r6qHI0e0uluDt8A	false	-	his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9UNE7	uniprotkb:P22314	intact:EBI-357085|uniprotkb:O60526|uniprotkb:Q969U2|uniprotkb:Q9HBT1|uniprotkb:A2IDB9|ensembl:ENSP00000219548	intact:EBI-709688|uniprotkb:Q96E13|uniprotkb:Q5JRR8|ensembl:ENSP00000338413|ensembl:ENSP00000366568	psi-mi:chip_human(display_long)|uniprotkb:CHIP(gene name synonym)|uniprotkb:STUB1(gene name)|psi-mi:STUB1(display_short)|uniprotkb:PP1131(orf name)|uniprotkb:Carboxy terminus of Hsp70-interacting protein(gene name synonym)|uniprotkb:STIP1 homology and U box-containing protein 1(gene name synonym)|uniprotkb:CLL-associated antigen KW-8(gene name synonym)|uniprotkb:Antigen NY-CO-7(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase CHIP(gene name synonym)	psi-mi:uba1_human(display_long)|uniprotkb:Ubiquitin-activating enzyme E1(gene name synonym)|uniprotkb:Protein A1S9(gene name synonym)|uniprotkb:UBA1(gene name)|psi-mi:UBA1(display_short)|uniprotkb:A1S9T(gene name synonym)|uniprotkb:UBE1(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9971212|imex:IM-22822-62	author-confidence:Z-score = 18.62	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	dip:DIP-29752N|refseq:NP_005852.2|refseq:NP_001280126.1|ensembl:ENSG00000103266(gene)|ensembl:ENST00000219548(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0002931"(response to ischemia)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006515"(protein quality control for misfolded or incompletely synthesized proteins)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019899"(enzyme binding)|go:"GO:0019900"(kinase binding)|go:"GO:0030018"(Z disc)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030911"(TPR domain binding)|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031371"(ubiquitin conjugating enzyme complex)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031943"(regulation of glucocorticoid metabolic process)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0034450"(ubiquitin-ubiquitin ligase activity)|go:"GO:0034605"(cellular response to heat)|go:"GO:0038128"(ERBB2 signaling pathway)|go:"GO:0042405"(nuclear inclusion body)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045862"(positive regulation of proteolysis)|go:"GO:0046332"(SMAD binding)|go:"GO:0048156"(tau protein binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0051604"(protein maturation)|go:"GO:0051787"(misfolded protein binding)|go:"GO:0030579"(ubiquitin-dependent SMAD protein catabolic process)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0061684"(chaperone-mediated autophagy)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0071218"(cellular response to misfolded protein)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0090035"(positive regulation of chaperone-mediated protein complex assembly)|go:"GO:0101031"(chaperone complex)|interpro:IPR003613(U box)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR019734|interpro:IPR041312|mint:Q9UNE7|rcsb pdb:4KBQ|rcsb pdb:6EFK|rcsb pdb:6NSV|reactome:R-HSA-2173788|reactome:R-HSA-5213460|reactome:R-HSA-5675482|reactome:R-HSA-8863795|reactome:R-HSA-8939902|reactome:R-HSA-8948751|reactome:R-HSA-983168	refseq:NP_003325.2|refseq:NP_695012.1|refseq:XP_016885269.1|refseq:XP_016885270.1|dip:DIP-33686N|ensembl:ENSG00000130985(gene)|ensembl:ENST00000335972(transcript)|ensembl:ENST00000377351(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0004839"(ubiquitin activating enzyme activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0032446"(protein modification by small protein conjugation)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000011(Ubiquitin-activating enzyme, E1)|interpro:IPR000594(UBA/THIF-type NAD/FAD binding fold)|interpro:IPR018074|interpro:IPR018075|interpro:IPR018965|interpro:IPR019572|interpro:IPR032418|interpro:IPR032420|interpro:IPR033127|interpro:IPR035985|interpro:IPR038252|interpro:IPR042063|interpro:IPR042302|interpro:IPR042449|mint:P22314|rcsb pdb:4P22|rcsb pdb:6DC6|reactome:R-HSA-8866652|reactome:R-HSA-983168	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S2|caution:"UBE2N has been marked as the enzyme in this assay, although it is the UBE2N-UBE2V1 complex that has ubiquitinase (E3) activity. Neither UBE2N nor UBE2V1 have E2 or E3 activity on their own."|resulting-ptm:Q9UNE7 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:h4QyIM0TptgkQppPUgiKn68XjP49606	rogid:q+vEeA0XLST0Zz173bmEt0dNbDE9606	intact-crc:7AE4130DC911D703|rigid:O+267gHrEqc1r6qHI0e0uluDt8A	false	-	his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9UNE7	uniprotkb:P61088	intact:EBI-357085|uniprotkb:O60526|uniprotkb:Q969U2|uniprotkb:Q9HBT1|uniprotkb:A2IDB9|ensembl:ENSP00000219548	intact:EBI-1052908|uniprotkb:Q16781|uniprotkb:Q53Y81|ensembl:ENSP00000316176	psi-mi:chip_human(display_long)|uniprotkb:CHIP(gene name synonym)|uniprotkb:STUB1(gene name)|psi-mi:STUB1(display_short)|uniprotkb:PP1131(orf name)|uniprotkb:Carboxy terminus of Hsp70-interacting protein(gene name synonym)|uniprotkb:STIP1 homology and U box-containing protein 1(gene name synonym)|uniprotkb:CLL-associated antigen KW-8(gene name synonym)|uniprotkb:Antigen NY-CO-7(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase CHIP(gene name synonym)	psi-mi:ube2n_human(display_long)|uniprotkb:Ubiquitin-protein ligase N(gene name synonym)|uniprotkb:Ubiquitin carrier protein N(gene name synonym)|uniprotkb:Ubc13(gene name synonym)|uniprotkb:Bendless-like ubiquitin-conjugating enzyme(gene name synonym)|uniprotkb:UBE2N(gene name)|psi-mi:UBE2N(display_short)|uniprotkb:BLU(gene name synonym)|uniprotkb:UbcH13(gene name synonym)|uniprotkb:E2 ubiquitin-conjugating enzyme N(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9971212|imex:IM-22822-62	author-confidence:Z-score = 18.62	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	dip:DIP-29752N|refseq:NP_005852.2|refseq:NP_001280126.1|ensembl:ENSG00000103266(gene)|ensembl:ENST00000219548(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0002931"(response to ischemia)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006515"(protein quality control for misfolded or incompletely synthesized proteins)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019899"(enzyme binding)|go:"GO:0019900"(kinase binding)|go:"GO:0030018"(Z disc)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030911"(TPR domain binding)|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031371"(ubiquitin conjugating enzyme complex)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031943"(regulation of glucocorticoid metabolic process)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0034450"(ubiquitin-ubiquitin ligase activity)|go:"GO:0034605"(cellular response to heat)|go:"GO:0038128"(ERBB2 signaling pathway)|go:"GO:0042405"(nuclear inclusion body)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045862"(positive regulation of proteolysis)|go:"GO:0046332"(SMAD binding)|go:"GO:0048156"(tau protein binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0051604"(protein maturation)|go:"GO:0051787"(misfolded protein binding)|go:"GO:0030579"(ubiquitin-dependent SMAD protein catabolic process)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0061684"(chaperone-mediated autophagy)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0071218"(cellular response to misfolded protein)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0090035"(positive regulation of chaperone-mediated protein complex assembly)|go:"GO:0101031"(chaperone complex)|interpro:IPR003613(U box)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR019734|interpro:IPR041312|mint:Q9UNE7|rcsb pdb:4KBQ|rcsb pdb:6EFK|rcsb pdb:6NSV|reactome:R-HSA-2173788|reactome:R-HSA-5213460|reactome:R-HSA-5675482|reactome:R-HSA-8863795|reactome:R-HSA-8939902|reactome:R-HSA-8948751|reactome:R-HSA-983168	refseq:NP_003339.1|dip:DIP-29829N|ensembl:ENSG00000177889(gene)|ensembl:ENST00000318066(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000729"(DNA double-strand break processing)|go:"GO:0001650"(fibrillar center)|go:"GO:0003723"(RNA binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006282"(regulation of DNA repair)|go:"GO:0006301"(postreplication repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016574"(histone ubiquitination)|go:"GO:0031058"(positive regulation of histone modification)|go:"GO:0031372"(UBC13-MMS2 complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033182"(regulation of histone ubiquitination)|go:"GO:0035370"(UBC13-UEV1A complex)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0061631"(ubiquitin conjugating enzyme activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070534"(protein K63-linked ubiquitination)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|interpro:IPR023313|rcsb pdb:1J7D|rcsb pdb:2C2V|rcsb pdb:3HCT|rcsb pdb:3HCU|rcsb pdb:3VON|rcsb pdb:3W31|rcsb pdb:4DHI|rcsb pdb:4DHJ|rcsb pdb:4DHZ|rcsb pdb:4IP3|rcsb pdb:4NR3|rcsb pdb:4NRG|rcsb pdb:4NRI|rcsb pdb:4ONL|rcsb pdb:4ONM|rcsb pdb:4ONN|rcsb pdb:4ORH|rcsb pdb:4TKP|rcsb pdb:4WHV|rcsb pdb:5AIT|rcsb pdb:5AIU|rcsb pdb:5EYA|rcsb pdb:5H7S|rcsb pdb:5VNZ|rcsb pdb:5VO0|rcsb pdb:5YWR|rcsb pdb:6D6I|rcsb pdb:6JKY|rcsb pdb:6KFP|rcsb pdb:6KG6|rcsb pdb:6KL4|rcsb pdb:6LP2|rcsb pdb:6P5B|rcsb pdb:6S53|reactome:R-HSA-168927|reactome:R-HSA-202424|reactome:R-HSA-2871837|reactome:R-HSA-445989|reactome:R-HSA-450302|reactome:R-HSA-450321|reactome:R-HSA-5607764|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-5696395|reactome:R-HSA-69473|reactome:R-HSA-8866654|reactome:R-HSA-9020702|reactome:R-HSA-937039|reactome:R-HSA-937041|reactome:R-HSA-9646399|reactome:R-HSA-975110|reactome:R-HSA-975144|reactome:R-HSA-983168|rcsb pdb:6ULH|rcsb pdb:6UMP|rcsb pdb:6UMS|rcsb pdb:7BBD|rcsb pdb:7BBF|rcsb pdb:7BXG|reactome:R-HSA-1169408|reactome:R-HSA-168638	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S2|caution:"UBE2N has been marked as the enzyme in this assay, although it is the UBE2N-UBE2V1 complex that has ubiquitinase (E3) activity. Neither UBE2N nor UBE2V1 have E2 or E3 activity on their own."|resulting-ptm:Q9UNE7 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:h4QyIM0TptgkQppPUgiKn68XjP49606	rogid:dqdszHlq5FLPHC6UWX6uvkC6Yz89606	intact-crc:7AE4130DC911D703|rigid:O+267gHrEqc1r6qHI0e0uluDt8A	false	-	his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9UNA4	uniprotkb:Q13404	intact:EBI-741774|ensembl:ENSP00000462664|uniprotkb:Q8N590|uniprotkb:Q9H0S1|uniprotkb:Q9NYH6	intact:EBI-1050671|uniprotkb:Q13403|uniprotkb:Q13532|uniprotkb:Q96H34|uniprotkb:Q9GZT0|uniprotkb:Q9GZW1|uniprotkb:Q9H4J3|uniprotkb:Q9H4J4|uniprotkb:Q9UKL1|uniprotkb:Q9UM48|uniprotkb:Q9UM49|uniprotkb:Q9UM50|uniprotkb:Q5TGE3|uniprotkb:E1P629|uniprotkb:Q5TGE0|ensembl:ENSP00000360739	psi-mi:poli_human(display_long)|uniprotkb:Eta2(gene name synonym)|uniprotkb:RAD30 homolog B(gene name synonym)|uniprotkb:POLI(gene name)|psi-mi:POLI(display_short)|uniprotkb:RAD30B(gene name synonym)	psi-mi:ub2v1_human(display_long)|uniprotkb:CROC-1(gene name synonym)|uniprotkb:TRAF6-regulated IKK activator 1 beta Uev1A(gene name synonym)|uniprotkb:P/OKcl.19(orf name)|uniprotkb:UBE2V1(gene name)|psi-mi:UBE2V1(display_short)|uniprotkb:CROC1(gene name synonym)|uniprotkb:UBE2V(gene name synonym)|uniprotkb:UEV1(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9971191|imex:IM-22822-61	author-confidence:Z-score = 8.64	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rcsb pdb:1T3N|rcsb pdb:1ZET|rcsb pdb:2ALZ|rcsb pdb:2DPI|rcsb pdb:2DPJ|rcsb pdb:2FLL|rcsb pdb:2FLN|rcsb pdb:2FLP|rcsb pdb:2KHU|rcsb pdb:2KHW|rcsb pdb:2KTF|rcsb pdb:2L0F|rcsb pdb:2L0G|rcsb pdb:2MBB|rcsb pdb:3EPG|rcsb pdb:3EPI|rcsb pdb:3G6V|rcsb pdb:3G6X|rcsb pdb:3G6Y|rcsb pdb:3GV5|rcsb pdb:3GV7|rcsb pdb:3GV8|rcsb pdb:3H40|rcsb pdb:3H4B|rcsb pdb:3H4D|ensembl:ENSG00000101751(gene)|ensembl:ENST00000579534(transcript)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0003887"(DNA-directed DNA polymerase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006260"(DNA replication)|go:"GO:0006281"(DNA repair)|go:"GO:0016607"(nuclear speck)|go:"GO:0019985"(translesion synthesis)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042276"(error-prone translesion synthesis)|go:"GO:0046872"(metal ion binding)|interpro:IPR001126(UMUC-like DNA-repair protein)|interpro:IPR017961|interpro:IPR036775|interpro:IPR043128|interpro:IPR043502|mint:Q9UNA4|refseq:NP_009126.2|rcsb pdb:3NGD|rcsb pdb:3OSN|rcsb pdb:3Q8P|rcsb pdb:3Q8Q|rcsb pdb:3Q8R|rcsb pdb:3Q8S|rcsb pdb:4EBC|rcsb pdb:4EBD|rcsb pdb:4EBE|rcsb pdb:4EYI|rcsb pdb:4FS1|rcsb pdb:4FS2|rcsb pdb:5KT2|rcsb pdb:5KT3|rcsb pdb:5KT4|rcsb pdb:5KT5|rcsb pdb:5KT6|rcsb pdb:5KT7|rcsb pdb:5ULW|rcsb pdb:5ULX|reactome:R-HSA-5656121|reactome:R-HSA-5656169|rcsb pdb:4EYH	refseq:NP_001027459.1|refseq:NP_068823.2|refseq:NP_071887.1|refseq:NP_954595.1|refseq:NP_954673.1|refseq:NP_001244322.1|refseq:NP_001244323.1|refseq:NP_001244325.1|ensembl:ENSG00000244687(gene)|ensembl:ENST00000371674(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006282"(regulation of DNA repair)|go:"GO:0006301"(postreplication repair)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0030154"(cell differentiation)|go:"GO:0031371"(ubiquitin conjugating enzyme complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035370"(UBC13-UEV1A complex)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070534"(protein K63-linked ubiquitination)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|rcsb pdb:2A4D|rcsb pdb:2C2V|rcsb pdb:2HLW|rcsb pdb:6D6I|reactome:R-HSA-168638|reactome:R-HSA-168927|reactome:R-HSA-202424|reactome:R-HSA-2871837|reactome:R-HSA-445989|reactome:R-HSA-450302|reactome:R-HSA-450321|reactome:R-HSA-5607764|reactome:R-HSA-9020702|reactome:R-HSA-937039|reactome:R-HSA-937041|reactome:R-HSA-9646399|reactome:R-HSA-975110|reactome:R-HSA-975144|reactome:R-HSA-983168|dip:DIP-41911N	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S2|caution:"UBE2N has been marked as the enzyme in this assay, although it is the UBE2N-UBE2V1 complex that has ubiquitinase (E3) activity. Neither UBE2N nor UBE2V1 have E2 or E3 activity on their own."|resulting-ptm:Q9UNA4 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:iH6WfDK+UIzw5XQSHo9wWSfnrJU9606	rogid:x95N7Dj2KIqu5gySX59xLmfthUg9606	intact-crc:DA1463FCA45C666B|rigid:zoaCjudeDzLO0t2vkKNfEALglNQ	false	-	his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9UNA4	uniprotkb:P22314	intact:EBI-741774|ensembl:ENSP00000462664|uniprotkb:Q8N590|uniprotkb:Q9H0S1|uniprotkb:Q9NYH6	intact:EBI-709688|uniprotkb:Q96E13|uniprotkb:Q5JRR8|ensembl:ENSP00000338413|ensembl:ENSP00000366568	psi-mi:poli_human(display_long)|uniprotkb:Eta2(gene name synonym)|uniprotkb:RAD30 homolog B(gene name synonym)|uniprotkb:POLI(gene name)|psi-mi:POLI(display_short)|uniprotkb:RAD30B(gene name synonym)	psi-mi:uba1_human(display_long)|uniprotkb:Ubiquitin-activating enzyme E1(gene name synonym)|uniprotkb:Protein A1S9(gene name synonym)|uniprotkb:UBA1(gene name)|psi-mi:UBA1(display_short)|uniprotkb:A1S9T(gene name synonym)|uniprotkb:UBE1(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9971191|imex:IM-22822-61	author-confidence:Z-score = 8.64	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rcsb pdb:1T3N|rcsb pdb:1ZET|rcsb pdb:2ALZ|rcsb pdb:2DPI|rcsb pdb:2DPJ|rcsb pdb:2FLL|rcsb pdb:2FLN|rcsb pdb:2FLP|rcsb pdb:2KHU|rcsb pdb:2KHW|rcsb pdb:2KTF|rcsb pdb:2L0F|rcsb pdb:2L0G|rcsb pdb:2MBB|rcsb pdb:3EPG|rcsb pdb:3EPI|rcsb pdb:3G6V|rcsb pdb:3G6X|rcsb pdb:3G6Y|rcsb pdb:3GV5|rcsb pdb:3GV7|rcsb pdb:3GV8|rcsb pdb:3H40|rcsb pdb:3H4B|rcsb pdb:3H4D|ensembl:ENSG00000101751(gene)|ensembl:ENST00000579534(transcript)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0003887"(DNA-directed DNA polymerase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006260"(DNA replication)|go:"GO:0006281"(DNA repair)|go:"GO:0016607"(nuclear speck)|go:"GO:0019985"(translesion synthesis)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042276"(error-prone translesion synthesis)|go:"GO:0046872"(metal ion binding)|interpro:IPR001126(UMUC-like DNA-repair protein)|interpro:IPR017961|interpro:IPR036775|interpro:IPR043128|interpro:IPR043502|mint:Q9UNA4|refseq:NP_009126.2|rcsb pdb:3NGD|rcsb pdb:3OSN|rcsb pdb:3Q8P|rcsb pdb:3Q8Q|rcsb pdb:3Q8R|rcsb pdb:3Q8S|rcsb pdb:4EBC|rcsb pdb:4EBD|rcsb pdb:4EBE|rcsb pdb:4EYI|rcsb pdb:4FS1|rcsb pdb:4FS2|rcsb pdb:5KT2|rcsb pdb:5KT3|rcsb pdb:5KT4|rcsb pdb:5KT5|rcsb pdb:5KT6|rcsb pdb:5KT7|rcsb pdb:5ULW|rcsb pdb:5ULX|reactome:R-HSA-5656121|reactome:R-HSA-5656169|rcsb pdb:4EYH	refseq:NP_003325.2|refseq:NP_695012.1|refseq:XP_016885269.1|refseq:XP_016885270.1|dip:DIP-33686N|ensembl:ENSG00000130985(gene)|ensembl:ENST00000335972(transcript)|ensembl:ENST00000377351(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0004839"(ubiquitin activating enzyme activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0032446"(protein modification by small protein conjugation)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000011(Ubiquitin-activating enzyme, E1)|interpro:IPR000594(UBA/THIF-type NAD/FAD binding fold)|interpro:IPR018074|interpro:IPR018075|interpro:IPR018965|interpro:IPR019572|interpro:IPR032418|interpro:IPR032420|interpro:IPR033127|interpro:IPR035985|interpro:IPR038252|interpro:IPR042063|interpro:IPR042302|interpro:IPR042449|mint:P22314|rcsb pdb:4P22|rcsb pdb:6DC6|reactome:R-HSA-8866652|reactome:R-HSA-983168	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S2|caution:"UBE2N has been marked as the enzyme in this assay, although it is the UBE2N-UBE2V1 complex that has ubiquitinase (E3) activity. Neither UBE2N nor UBE2V1 have E2 or E3 activity on their own."|resulting-ptm:Q9UNA4 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:iH6WfDK+UIzw5XQSHo9wWSfnrJU9606	rogid:q+vEeA0XLST0Zz173bmEt0dNbDE9606	intact-crc:DA1463FCA45C666B|rigid:zoaCjudeDzLO0t2vkKNfEALglNQ	false	-	his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9UNA4	uniprotkb:P61088	intact:EBI-741774|ensembl:ENSP00000462664|uniprotkb:Q8N590|uniprotkb:Q9H0S1|uniprotkb:Q9NYH6	intact:EBI-1052908|uniprotkb:Q16781|uniprotkb:Q53Y81|ensembl:ENSP00000316176	psi-mi:poli_human(display_long)|uniprotkb:Eta2(gene name synonym)|uniprotkb:RAD30 homolog B(gene name synonym)|uniprotkb:POLI(gene name)|psi-mi:POLI(display_short)|uniprotkb:RAD30B(gene name synonym)	psi-mi:ube2n_human(display_long)|uniprotkb:Ubiquitin-protein ligase N(gene name synonym)|uniprotkb:Ubiquitin carrier protein N(gene name synonym)|uniprotkb:Ubc13(gene name synonym)|uniprotkb:Bendless-like ubiquitin-conjugating enzyme(gene name synonym)|uniprotkb:UBE2N(gene name)|psi-mi:UBE2N(display_short)|uniprotkb:BLU(gene name synonym)|uniprotkb:UbcH13(gene name synonym)|uniprotkb:E2 ubiquitin-conjugating enzyme N(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9971191|imex:IM-22822-61	author-confidence:Z-score = 8.64	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rcsb pdb:1T3N|rcsb pdb:1ZET|rcsb pdb:2ALZ|rcsb pdb:2DPI|rcsb pdb:2DPJ|rcsb pdb:2FLL|rcsb pdb:2FLN|rcsb pdb:2FLP|rcsb pdb:2KHU|rcsb pdb:2KHW|rcsb pdb:2KTF|rcsb pdb:2L0F|rcsb pdb:2L0G|rcsb pdb:2MBB|rcsb pdb:3EPG|rcsb pdb:3EPI|rcsb pdb:3G6V|rcsb pdb:3G6X|rcsb pdb:3G6Y|rcsb pdb:3GV5|rcsb pdb:3GV7|rcsb pdb:3GV8|rcsb pdb:3H40|rcsb pdb:3H4B|rcsb pdb:3H4D|ensembl:ENSG00000101751(gene)|ensembl:ENST00000579534(transcript)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0003887"(DNA-directed DNA polymerase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006260"(DNA replication)|go:"GO:0006281"(DNA repair)|go:"GO:0016607"(nuclear speck)|go:"GO:0019985"(translesion synthesis)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042276"(error-prone translesion synthesis)|go:"GO:0046872"(metal ion binding)|interpro:IPR001126(UMUC-like DNA-repair protein)|interpro:IPR017961|interpro:IPR036775|interpro:IPR043128|interpro:IPR043502|mint:Q9UNA4|refseq:NP_009126.2|rcsb pdb:3NGD|rcsb pdb:3OSN|rcsb pdb:3Q8P|rcsb pdb:3Q8Q|rcsb pdb:3Q8R|rcsb pdb:3Q8S|rcsb pdb:4EBC|rcsb pdb:4EBD|rcsb pdb:4EBE|rcsb pdb:4EYI|rcsb pdb:4FS1|rcsb pdb:4FS2|rcsb pdb:5KT2|rcsb pdb:5KT3|rcsb pdb:5KT4|rcsb pdb:5KT5|rcsb pdb:5KT6|rcsb pdb:5KT7|rcsb pdb:5ULW|rcsb pdb:5ULX|reactome:R-HSA-5656121|reactome:R-HSA-5656169|rcsb pdb:4EYH	refseq:NP_003339.1|dip:DIP-29829N|ensembl:ENSG00000177889(gene)|ensembl:ENST00000318066(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000729"(DNA double-strand break processing)|go:"GO:0001650"(fibrillar center)|go:"GO:0003723"(RNA binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006282"(regulation of DNA repair)|go:"GO:0006301"(postreplication repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016574"(histone ubiquitination)|go:"GO:0031058"(positive regulation of histone modification)|go:"GO:0031372"(UBC13-MMS2 complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033182"(regulation of histone ubiquitination)|go:"GO:0035370"(UBC13-UEV1A complex)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0061631"(ubiquitin conjugating enzyme activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070534"(protein K63-linked ubiquitination)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|interpro:IPR023313|rcsb pdb:1J7D|rcsb pdb:2C2V|rcsb pdb:3HCT|rcsb pdb:3HCU|rcsb pdb:3VON|rcsb pdb:3W31|rcsb pdb:4DHI|rcsb pdb:4DHJ|rcsb pdb:4DHZ|rcsb pdb:4IP3|rcsb pdb:4NR3|rcsb pdb:4NRG|rcsb pdb:4NRI|rcsb pdb:4ONL|rcsb pdb:4ONM|rcsb pdb:4ONN|rcsb pdb:4ORH|rcsb pdb:4TKP|rcsb pdb:4WHV|rcsb pdb:5AIT|rcsb pdb:5AIU|rcsb pdb:5EYA|rcsb pdb:5H7S|rcsb pdb:5VNZ|rcsb pdb:5VO0|rcsb pdb:5YWR|rcsb pdb:6D6I|rcsb pdb:6JKY|rcsb pdb:6KFP|rcsb pdb:6KG6|rcsb pdb:6KL4|rcsb pdb:6LP2|rcsb pdb:6P5B|rcsb pdb:6S53|reactome:R-HSA-168927|reactome:R-HSA-202424|reactome:R-HSA-2871837|reactome:R-HSA-445989|reactome:R-HSA-450302|reactome:R-HSA-450321|reactome:R-HSA-5607764|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-5696395|reactome:R-HSA-69473|reactome:R-HSA-8866654|reactome:R-HSA-9020702|reactome:R-HSA-937039|reactome:R-HSA-937041|reactome:R-HSA-9646399|reactome:R-HSA-975110|reactome:R-HSA-975144|reactome:R-HSA-983168|rcsb pdb:6ULH|rcsb pdb:6UMP|rcsb pdb:6UMS|rcsb pdb:7BBD|rcsb pdb:7BBF|rcsb pdb:7BXG|reactome:R-HSA-1169408|reactome:R-HSA-168638	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S2|caution:"UBE2N has been marked as the enzyme in this assay, although it is the UBE2N-UBE2V1 complex that has ubiquitinase (E3) activity. Neither UBE2N nor UBE2V1 have E2 or E3 activity on their own."|resulting-ptm:Q9UNA4 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:iH6WfDK+UIzw5XQSHo9wWSfnrJU9606	rogid:dqdszHlq5FLPHC6UWX6uvkC6Yz89606	intact-crc:DA1463FCA45C666B|rigid:zoaCjudeDzLO0t2vkKNfEALglNQ	false	-	his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q13404	uniprotkb:P22314	intact:EBI-1050671|uniprotkb:Q13403|uniprotkb:Q13532|uniprotkb:Q96H34|uniprotkb:Q9GZT0|uniprotkb:Q9GZW1|uniprotkb:Q9H4J3|uniprotkb:Q9H4J4|uniprotkb:Q9UKL1|uniprotkb:Q9UM48|uniprotkb:Q9UM49|uniprotkb:Q9UM50|uniprotkb:Q5TGE3|uniprotkb:E1P629|uniprotkb:Q5TGE0|ensembl:ENSP00000360739	intact:EBI-709688|uniprotkb:Q96E13|uniprotkb:Q5JRR8|ensembl:ENSP00000338413|ensembl:ENSP00000366568	psi-mi:ub2v1_human(display_long)|uniprotkb:CROC-1(gene name synonym)|uniprotkb:TRAF6-regulated IKK activator 1 beta Uev1A(gene name synonym)|uniprotkb:P/OKcl.19(orf name)|uniprotkb:UBE2V1(gene name)|psi-mi:UBE2V1(display_short)|uniprotkb:CROC1(gene name synonym)|uniprotkb:UBE2V(gene name synonym)|uniprotkb:UEV1(gene name synonym)	psi-mi:uba1_human(display_long)|uniprotkb:Ubiquitin-activating enzyme E1(gene name synonym)|uniprotkb:Protein A1S9(gene name synonym)|uniprotkb:UBA1(gene name)|psi-mi:UBA1(display_short)|uniprotkb:A1S9T(gene name synonym)|uniprotkb:UBE1(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9971170|imex:IM-22822-60	author-confidence:Z-score = 3.55	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001027459.1|refseq:NP_068823.2|refseq:NP_071887.1|refseq:NP_954595.1|refseq:NP_954673.1|refseq:NP_001244322.1|refseq:NP_001244323.1|refseq:NP_001244325.1|ensembl:ENSG00000244687(gene)|ensembl:ENST00000371674(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006282"(regulation of DNA repair)|go:"GO:0006301"(postreplication repair)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0030154"(cell differentiation)|go:"GO:0031371"(ubiquitin conjugating enzyme complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035370"(UBC13-UEV1A complex)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070534"(protein K63-linked ubiquitination)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|rcsb pdb:2A4D|rcsb pdb:2C2V|rcsb pdb:2HLW|rcsb pdb:6D6I|reactome:R-HSA-168638|reactome:R-HSA-168927|reactome:R-HSA-202424|reactome:R-HSA-2871837|reactome:R-HSA-445989|reactome:R-HSA-450302|reactome:R-HSA-450321|reactome:R-HSA-5607764|reactome:R-HSA-9020702|reactome:R-HSA-937039|reactome:R-HSA-937041|reactome:R-HSA-9646399|reactome:R-HSA-975110|reactome:R-HSA-975144|reactome:R-HSA-983168|dip:DIP-41911N	refseq:NP_003325.2|refseq:NP_695012.1|refseq:XP_016885269.1|refseq:XP_016885270.1|dip:DIP-33686N|ensembl:ENSG00000130985(gene)|ensembl:ENST00000335972(transcript)|ensembl:ENST00000377351(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0004839"(ubiquitin activating enzyme activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0032446"(protein modification by small protein conjugation)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000011(Ubiquitin-activating enzyme, E1)|interpro:IPR000594(UBA/THIF-type NAD/FAD binding fold)|interpro:IPR018074|interpro:IPR018075|interpro:IPR018965|interpro:IPR019572|interpro:IPR032418|interpro:IPR032420|interpro:IPR033127|interpro:IPR035985|interpro:IPR038252|interpro:IPR042063|interpro:IPR042302|interpro:IPR042449|mint:P22314|rcsb pdb:4P22|rcsb pdb:6DC6|reactome:R-HSA-8866652|reactome:R-HSA-983168	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S2|caution:"UBE2N has been marked as the enzyme in this assay, although it is the UBE2N-UBE2V1 complex that has ubiquitinase (E3) activity. Neither UBE2N nor UBE2V1 have E2 or E3 activity on their own."|resulting-ptm:Q9NRR5 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:x95N7Dj2KIqu5gySX59xLmfthUg9606	rogid:q+vEeA0XLST0Zz173bmEt0dNbDE9606	intact-crc:45A55A6018D76A99|rigid:tZmPPoUmePSvHDA1MiUl7/XJkqo	false	his tag:?-?	his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q13404	uniprotkb:P61088	intact:EBI-1050671|uniprotkb:Q13403|uniprotkb:Q13532|uniprotkb:Q96H34|uniprotkb:Q9GZT0|uniprotkb:Q9GZW1|uniprotkb:Q9H4J3|uniprotkb:Q9H4J4|uniprotkb:Q9UKL1|uniprotkb:Q9UM48|uniprotkb:Q9UM49|uniprotkb:Q9UM50|uniprotkb:Q5TGE3|uniprotkb:E1P629|uniprotkb:Q5TGE0|ensembl:ENSP00000360739	intact:EBI-1052908|uniprotkb:Q16781|uniprotkb:Q53Y81|ensembl:ENSP00000316176	psi-mi:ub2v1_human(display_long)|uniprotkb:CROC-1(gene name synonym)|uniprotkb:TRAF6-regulated IKK activator 1 beta Uev1A(gene name synonym)|uniprotkb:P/OKcl.19(orf name)|uniprotkb:UBE2V1(gene name)|psi-mi:UBE2V1(display_short)|uniprotkb:CROC1(gene name synonym)|uniprotkb:UBE2V(gene name synonym)|uniprotkb:UEV1(gene name synonym)	psi-mi:ube2n_human(display_long)|uniprotkb:Ubiquitin-protein ligase N(gene name synonym)|uniprotkb:Ubiquitin carrier protein N(gene name synonym)|uniprotkb:Ubc13(gene name synonym)|uniprotkb:Bendless-like ubiquitin-conjugating enzyme(gene name synonym)|uniprotkb:UBE2N(gene name)|psi-mi:UBE2N(display_short)|uniprotkb:BLU(gene name synonym)|uniprotkb:UbcH13(gene name synonym)|uniprotkb:E2 ubiquitin-conjugating enzyme N(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9971170|imex:IM-22822-60	author-confidence:Z-score = 3.55	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001027459.1|refseq:NP_068823.2|refseq:NP_071887.1|refseq:NP_954595.1|refseq:NP_954673.1|refseq:NP_001244322.1|refseq:NP_001244323.1|refseq:NP_001244325.1|ensembl:ENSG00000244687(gene)|ensembl:ENST00000371674(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006282"(regulation of DNA repair)|go:"GO:0006301"(postreplication repair)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0030154"(cell differentiation)|go:"GO:0031371"(ubiquitin conjugating enzyme complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035370"(UBC13-UEV1A complex)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070534"(protein K63-linked ubiquitination)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|rcsb pdb:2A4D|rcsb pdb:2C2V|rcsb pdb:2HLW|rcsb pdb:6D6I|reactome:R-HSA-168638|reactome:R-HSA-168927|reactome:R-HSA-202424|reactome:R-HSA-2871837|reactome:R-HSA-445989|reactome:R-HSA-450302|reactome:R-HSA-450321|reactome:R-HSA-5607764|reactome:R-HSA-9020702|reactome:R-HSA-937039|reactome:R-HSA-937041|reactome:R-HSA-9646399|reactome:R-HSA-975110|reactome:R-HSA-975144|reactome:R-HSA-983168|dip:DIP-41911N	refseq:NP_003339.1|dip:DIP-29829N|ensembl:ENSG00000177889(gene)|ensembl:ENST00000318066(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000729"(DNA double-strand break processing)|go:"GO:0001650"(fibrillar center)|go:"GO:0003723"(RNA binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006282"(regulation of DNA repair)|go:"GO:0006301"(postreplication repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016574"(histone ubiquitination)|go:"GO:0031058"(positive regulation of histone modification)|go:"GO:0031372"(UBC13-MMS2 complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033182"(regulation of histone ubiquitination)|go:"GO:0035370"(UBC13-UEV1A complex)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0061631"(ubiquitin conjugating enzyme activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070534"(protein K63-linked ubiquitination)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|interpro:IPR023313|rcsb pdb:1J7D|rcsb pdb:2C2V|rcsb pdb:3HCT|rcsb pdb:3HCU|rcsb pdb:3VON|rcsb pdb:3W31|rcsb pdb:4DHI|rcsb pdb:4DHJ|rcsb pdb:4DHZ|rcsb pdb:4IP3|rcsb pdb:4NR3|rcsb pdb:4NRG|rcsb pdb:4NRI|rcsb pdb:4ONL|rcsb pdb:4ONM|rcsb pdb:4ONN|rcsb pdb:4ORH|rcsb pdb:4TKP|rcsb pdb:4WHV|rcsb pdb:5AIT|rcsb pdb:5AIU|rcsb pdb:5EYA|rcsb pdb:5H7S|rcsb pdb:5VNZ|rcsb pdb:5VO0|rcsb pdb:5YWR|rcsb pdb:6D6I|rcsb pdb:6JKY|rcsb pdb:6KFP|rcsb pdb:6KG6|rcsb pdb:6KL4|rcsb pdb:6LP2|rcsb pdb:6P5B|rcsb pdb:6S53|reactome:R-HSA-168927|reactome:R-HSA-202424|reactome:R-HSA-2871837|reactome:R-HSA-445989|reactome:R-HSA-450302|reactome:R-HSA-450321|reactome:R-HSA-5607764|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-5696395|reactome:R-HSA-69473|reactome:R-HSA-8866654|reactome:R-HSA-9020702|reactome:R-HSA-937039|reactome:R-HSA-937041|reactome:R-HSA-9646399|reactome:R-HSA-975110|reactome:R-HSA-975144|reactome:R-HSA-983168|rcsb pdb:6ULH|rcsb pdb:6UMP|rcsb pdb:6UMS|rcsb pdb:7BBD|rcsb pdb:7BBF|rcsb pdb:7BXG|reactome:R-HSA-1169408|reactome:R-HSA-168638	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S2|caution:"UBE2N has been marked as the enzyme in this assay, although it is the UBE2N-UBE2V1 complex that has ubiquitinase (E3) activity. Neither UBE2N nor UBE2V1 have E2 or E3 activity on their own."|resulting-ptm:Q9NRR5 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:x95N7Dj2KIqu5gySX59xLmfthUg9606	rogid:dqdszHlq5FLPHC6UWX6uvkC6Yz89606	intact-crc:45A55A6018D76A99|rigid:tZmPPoUmePSvHDA1MiUl7/XJkqo	false	his tag:?-?	his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q13404	uniprotkb:Q9NRR5	intact:EBI-1050671|uniprotkb:Q13403|uniprotkb:Q13532|uniprotkb:Q96H34|uniprotkb:Q9GZT0|uniprotkb:Q9GZW1|uniprotkb:Q9H4J3|uniprotkb:Q9H4J4|uniprotkb:Q9UKL1|uniprotkb:Q9UM48|uniprotkb:Q9UM49|uniprotkb:Q9UM50|uniprotkb:Q5TGE3|uniprotkb:E1P629|uniprotkb:Q5TGE0|ensembl:ENSP00000360739	intact:EBI-711226|intact:EBI-722657|uniprotkb:Q9BR98|uniprotkb:Q9UHX4|ensembl:ENSP00000357292|uniprotkb:Q5VYA1|uniprotkb:B2RAY7|uniprotkb:A6ND44|uniprotkb:Q5VYA0	psi-mi:ub2v1_human(display_long)|uniprotkb:CROC-1(gene name synonym)|uniprotkb:TRAF6-regulated IKK activator 1 beta Uev1A(gene name synonym)|uniprotkb:P/OKcl.19(orf name)|uniprotkb:UBE2V1(gene name)|psi-mi:UBE2V1(display_short)|uniprotkb:CROC1(gene name synonym)|uniprotkb:UBE2V(gene name synonym)|uniprotkb:UEV1(gene name synonym)	psi-mi:ubql4_human(display_long)|uniprotkb:UBQLN4(gene name)|psi-mi:UBQLN4(display_short)|uniprotkb:C1orf6(gene name synonym)|uniprotkb:UBIN(gene name synonym)|uniprotkb:Ataxin-1 ubiquitin-like-interacting protein A1U(gene name synonym)|uniprotkb:Ataxin-1 interacting ubiquitin-like protein(gene name synonym)|uniprotkb:CIP75(gene name synonym)|uniprotkb:Connexin43-interacting protein of 75 kDa(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9971170|imex:IM-22822-60	author-confidence:Z-score = 3.55	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001027459.1|refseq:NP_068823.2|refseq:NP_071887.1|refseq:NP_954595.1|refseq:NP_954673.1|refseq:NP_001244322.1|refseq:NP_001244323.1|refseq:NP_001244325.1|ensembl:ENSG00000244687(gene)|ensembl:ENST00000371674(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006282"(regulation of DNA repair)|go:"GO:0006301"(postreplication repair)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0030154"(cell differentiation)|go:"GO:0031371"(ubiquitin conjugating enzyme complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035370"(UBC13-UEV1A complex)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070534"(protein K63-linked ubiquitination)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|rcsb pdb:2A4D|rcsb pdb:2C2V|rcsb pdb:2HLW|rcsb pdb:6D6I|reactome:R-HSA-168638|reactome:R-HSA-168927|reactome:R-HSA-202424|reactome:R-HSA-2871837|reactome:R-HSA-445989|reactome:R-HSA-450302|reactome:R-HSA-450321|reactome:R-HSA-5607764|reactome:R-HSA-9020702|reactome:R-HSA-937039|reactome:R-HSA-937041|reactome:R-HSA-9646399|reactome:R-HSA-975110|reactome:R-HSA-975144|reactome:R-HSA-983168|dip:DIP-41911N	refseq:NP_001291271.1|refseq:NP_064516.2|ensembl:ENSG00000160803(gene)|interpro:IPR029071|ensembl:ENST00000368309(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005776"(autophagosome)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006914"(autophagy)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031593"(polyubiquitin modification-dependent protein binding)|go:"GO:0032434"(regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0036435"(K48-linked polyubiquitin modification-dependent protein binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0090734"(site of DNA damage)|go:"GO:1901097"(negative regulation of autophagosome maturation)|go:"GO:2000042"(negative regulation of double-strand break repair via homologous recombination)|interpro:IPR000626(Ubiquitin)|interpro:IPR006636(Heat shock chaperonin-binding)|interpro:IPR009060(UBA-like)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S2|caution:"UBE2N has been marked as the enzyme in this assay, although it is the UBE2N-UBE2V1 complex that has ubiquitinase (E3) activity. Neither UBE2N nor UBE2V1 have E2 or E3 activity on their own."|resulting-ptm:Q9NRR5 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:x95N7Dj2KIqu5gySX59xLmfthUg9606	rogid:H/kLIS8aSMue9jYu1Q4qTcBLt5o9606	intact-crc:45A55A6018D76A99|rigid:tZmPPoUmePSvHDA1MiUl7/XJkqo	false	his tag:?-?	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:G3V219	uniprotkb:Q62925	intact:EBI-9916770|ensembl:ENSP00000450394	intact:EBI-636664	psi-mi:g3v219_human(display_long)|uniprotkb:YAF2(gene name)|psi-mi:YAF2(display_short)|uniprotkb:hCG_1997687(orf name)	psi-mi:m3k1_rat(display_long)|uniprotkb:MAPK/ERK kinase kinase 1(gene name synonym)|uniprotkb:Map3k1(gene name)|psi-mi:Map3k1(display_short)|uniprotkb:Mekk(gene name synonym)|uniprotkb:Mekk1(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9971258|imex:IM-22822-64	author-confidence:Z-score = 7.42|author-confidence:Z-score = 8.64	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000015153(gene)|ensembl:ENST00000547351(transcript)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0046872"(metal ion binding)|interpro:IPR001876(Zinc finger, RanBP2-type)|interpro:IPR036443|interpro:IPR038039|interpro:IPR039958	rgd:620966|refseq:NP_446339.1|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR007527(Zinc finger, SWIM-type)|go:"GO:0000165"(MAPK cascade)|interpro:IPR016024(Armadillo-type fold)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0002011"(morphogenesis of an epithelial sheet)|go:"GO:0003382"(epithelial cell morphogenesis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004706"(JUN kinase kinase kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007254"(JNK cascade)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008432"(JUN kinase binding)|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0016020"(membrane)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0031434"(mitogen-activated protein kinase kinase binding)|go:"GO:0031941"(filamentous actin)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0042060"(wound healing)|go:"GO:0043010"(camera-type eye development)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046625"(sphingolipid binding)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050434"(positive regulation of viral transcription)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0061029"(eyelid development in camera-type eye)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|reactome:R-RNO-166058|reactome:R-RNO-2871796|reactome:R-RNO-975138|reactome:R-RNO-975871|interpro:IPR011989(Armadillo-like helical)|mint:Q62925	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S3|resulting-ptm:G3V219 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:zOjgmrRVXZMkx32Ql/WNSVFX+JQ9606	rogid:EwhjYjowkZIAt4UyPcZBUtf9uak10116	intact-crc:99FB424769310367|rigid:t4zI++28EFn3R96dDgIzKp8AX6w	false	-	sufficient binding region:433-481(IPR013083)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:G3V219	uniprotkb:Q13404	intact:EBI-9916770|ensembl:ENSP00000450394	intact:EBI-1050671|uniprotkb:Q13403|uniprotkb:Q13532|uniprotkb:Q96H34|uniprotkb:Q9GZT0|uniprotkb:Q9GZW1|uniprotkb:Q9H4J3|uniprotkb:Q9H4J4|uniprotkb:Q9UKL1|uniprotkb:Q9UM48|uniprotkb:Q9UM49|uniprotkb:Q9UM50|uniprotkb:Q5TGE3|uniprotkb:E1P629|uniprotkb:Q5TGE0|ensembl:ENSP00000360739	psi-mi:g3v219_human(display_long)|uniprotkb:YAF2(gene name)|psi-mi:YAF2(display_short)|uniprotkb:hCG_1997687(orf name)	psi-mi:ub2v1_human(display_long)|uniprotkb:CROC-1(gene name synonym)|uniprotkb:TRAF6-regulated IKK activator 1 beta Uev1A(gene name synonym)|uniprotkb:P/OKcl.19(orf name)|uniprotkb:UBE2V1(gene name)|psi-mi:UBE2V1(display_short)|uniprotkb:CROC1(gene name synonym)|uniprotkb:UBE2V(gene name synonym)|uniprotkb:UEV1(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9971258|imex:IM-22822-64	author-confidence:Z-score = 7.42|author-confidence:Z-score = 8.64	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000015153(gene)|ensembl:ENST00000547351(transcript)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0046872"(metal ion binding)|interpro:IPR001876(Zinc finger, RanBP2-type)|interpro:IPR036443|interpro:IPR038039|interpro:IPR039958	refseq:NP_001027459.1|refseq:NP_068823.2|refseq:NP_071887.1|refseq:NP_954595.1|refseq:NP_954673.1|refseq:NP_001244322.1|refseq:NP_001244323.1|refseq:NP_001244325.1|ensembl:ENSG00000244687(gene)|ensembl:ENST00000371674(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006282"(regulation of DNA repair)|go:"GO:0006301"(postreplication repair)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0030154"(cell differentiation)|go:"GO:0031371"(ubiquitin conjugating enzyme complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035370"(UBC13-UEV1A complex)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070534"(protein K63-linked ubiquitination)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|rcsb pdb:2A4D|rcsb pdb:2C2V|rcsb pdb:2HLW|rcsb pdb:6D6I|reactome:R-HSA-168638|reactome:R-HSA-168927|reactome:R-HSA-202424|reactome:R-HSA-2871837|reactome:R-HSA-445989|reactome:R-HSA-450302|reactome:R-HSA-450321|reactome:R-HSA-5607764|reactome:R-HSA-9020702|reactome:R-HSA-937039|reactome:R-HSA-937041|reactome:R-HSA-9646399|reactome:R-HSA-975110|reactome:R-HSA-975144|reactome:R-HSA-983168|dip:DIP-41911N	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S3|resulting-ptm:G3V219 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:zOjgmrRVXZMkx32Ql/WNSVFX+JQ9606	rogid:x95N7Dj2KIqu5gySX59xLmfthUg9606	intact-crc:99FB424769310367|rigid:t4zI++28EFn3R96dDgIzKp8AX6w	false	-	his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:G3V219	uniprotkb:P22314	intact:EBI-9916770|ensembl:ENSP00000450394	intact:EBI-709688|uniprotkb:Q96E13|uniprotkb:Q5JRR8|ensembl:ENSP00000338413|ensembl:ENSP00000366568	psi-mi:g3v219_human(display_long)|uniprotkb:YAF2(gene name)|psi-mi:YAF2(display_short)|uniprotkb:hCG_1997687(orf name)	psi-mi:uba1_human(display_long)|uniprotkb:Ubiquitin-activating enzyme E1(gene name synonym)|uniprotkb:Protein A1S9(gene name synonym)|uniprotkb:UBA1(gene name)|psi-mi:UBA1(display_short)|uniprotkb:A1S9T(gene name synonym)|uniprotkb:UBE1(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9971258|imex:IM-22822-64	author-confidence:Z-score = 7.42|author-confidence:Z-score = 8.64	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000015153(gene)|ensembl:ENST00000547351(transcript)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0046872"(metal ion binding)|interpro:IPR001876(Zinc finger, RanBP2-type)|interpro:IPR036443|interpro:IPR038039|interpro:IPR039958	refseq:NP_003325.2|refseq:NP_695012.1|refseq:XP_016885269.1|refseq:XP_016885270.1|dip:DIP-33686N|ensembl:ENSG00000130985(gene)|ensembl:ENST00000335972(transcript)|ensembl:ENST00000377351(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0004839"(ubiquitin activating enzyme activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0032446"(protein modification by small protein conjugation)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000011(Ubiquitin-activating enzyme, E1)|interpro:IPR000594(UBA/THIF-type NAD/FAD binding fold)|interpro:IPR018074|interpro:IPR018075|interpro:IPR018965|interpro:IPR019572|interpro:IPR032418|interpro:IPR032420|interpro:IPR033127|interpro:IPR035985|interpro:IPR038252|interpro:IPR042063|interpro:IPR042302|interpro:IPR042449|mint:P22314|rcsb pdb:4P22|rcsb pdb:6DC6|reactome:R-HSA-8866652|reactome:R-HSA-983168	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S3|resulting-ptm:G3V219 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:zOjgmrRVXZMkx32Ql/WNSVFX+JQ9606	rogid:q+vEeA0XLST0Zz173bmEt0dNbDE9606	intact-crc:99FB424769310367|rigid:t4zI++28EFn3R96dDgIzKp8AX6w	false	-	his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:G3V219	uniprotkb:P61088	intact:EBI-9916770|ensembl:ENSP00000450394	intact:EBI-1052908|uniprotkb:Q16781|uniprotkb:Q53Y81|ensembl:ENSP00000316176	psi-mi:g3v219_human(display_long)|uniprotkb:YAF2(gene name)|psi-mi:YAF2(display_short)|uniprotkb:hCG_1997687(orf name)	psi-mi:ube2n_human(display_long)|uniprotkb:Ubiquitin-protein ligase N(gene name synonym)|uniprotkb:Ubiquitin carrier protein N(gene name synonym)|uniprotkb:Ubc13(gene name synonym)|uniprotkb:Bendless-like ubiquitin-conjugating enzyme(gene name synonym)|uniprotkb:UBE2N(gene name)|psi-mi:UBE2N(display_short)|uniprotkb:BLU(gene name synonym)|uniprotkb:UbcH13(gene name synonym)|uniprotkb:E2 ubiquitin-conjugating enzyme N(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9971258|imex:IM-22822-64	author-confidence:Z-score = 7.42|author-confidence:Z-score = 8.64	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000015153(gene)|ensembl:ENST00000547351(transcript)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0046872"(metal ion binding)|interpro:IPR001876(Zinc finger, RanBP2-type)|interpro:IPR036443|interpro:IPR038039|interpro:IPR039958	refseq:NP_003339.1|dip:DIP-29829N|ensembl:ENSG00000177889(gene)|ensembl:ENST00000318066(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000729"(DNA double-strand break processing)|go:"GO:0001650"(fibrillar center)|go:"GO:0003723"(RNA binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006282"(regulation of DNA repair)|go:"GO:0006301"(postreplication repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016574"(histone ubiquitination)|go:"GO:0031058"(positive regulation of histone modification)|go:"GO:0031372"(UBC13-MMS2 complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033182"(regulation of histone ubiquitination)|go:"GO:0035370"(UBC13-UEV1A complex)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0061631"(ubiquitin conjugating enzyme activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070534"(protein K63-linked ubiquitination)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|interpro:IPR023313|rcsb pdb:1J7D|rcsb pdb:2C2V|rcsb pdb:3HCT|rcsb pdb:3HCU|rcsb pdb:3VON|rcsb pdb:3W31|rcsb pdb:4DHI|rcsb pdb:4DHJ|rcsb pdb:4DHZ|rcsb pdb:4IP3|rcsb pdb:4NR3|rcsb pdb:4NRG|rcsb pdb:4NRI|rcsb pdb:4ONL|rcsb pdb:4ONM|rcsb pdb:4ONN|rcsb pdb:4ORH|rcsb pdb:4TKP|rcsb pdb:4WHV|rcsb pdb:5AIT|rcsb pdb:5AIU|rcsb pdb:5EYA|rcsb pdb:5H7S|rcsb pdb:5VNZ|rcsb pdb:5VO0|rcsb pdb:5YWR|rcsb pdb:6D6I|rcsb pdb:6JKY|rcsb pdb:6KFP|rcsb pdb:6KG6|rcsb pdb:6KL4|rcsb pdb:6LP2|rcsb pdb:6P5B|rcsb pdb:6S53|reactome:R-HSA-168927|reactome:R-HSA-202424|reactome:R-HSA-2871837|reactome:R-HSA-445989|reactome:R-HSA-450302|reactome:R-HSA-450321|reactome:R-HSA-5607764|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-5696395|reactome:R-HSA-69473|reactome:R-HSA-8866654|reactome:R-HSA-9020702|reactome:R-HSA-937039|reactome:R-HSA-937041|reactome:R-HSA-9646399|reactome:R-HSA-975110|reactome:R-HSA-975144|reactome:R-HSA-983168|rcsb pdb:6ULH|rcsb pdb:6UMP|rcsb pdb:6UMS|rcsb pdb:7BBD|rcsb pdb:7BBF|rcsb pdb:7BXG|reactome:R-HSA-1169408|reactome:R-HSA-168638	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S3|resulting-ptm:G3V219 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:zOjgmrRVXZMkx32Ql/WNSVFX+JQ9606	rogid:dqdszHlq5FLPHC6UWX6uvkC6Yz89606	intact-crc:99FB424769310367|rigid:t4zI++28EFn3R96dDgIzKp8AX6w	false	-	his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:A6NI79	uniprotkb:Q62925	intact:EBI-5652866|uniprotkb:A8K9X6|ensembl:ENSP00000347586	intact:EBI-636664	psi-mi:ccd69_human(display_long)|uniprotkb:CCDC69(gene name)|psi-mi:CCDC69(display_short)	psi-mi:m3k1_rat(display_long)|uniprotkb:MAPK/ERK kinase kinase 1(gene name synonym)|uniprotkb:Map3k1(gene name)|psi-mi:Map3k1(display_short)|uniprotkb:Mekk(gene name synonym)|uniprotkb:Mekk1(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9971233|imex:IM-22822-63	author-confidence:Z-score = 3.22	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_056436.2|ensembl:ENSG00000198624(gene)|ensembl:ENST00000355417(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0008017"(microtubule binding)|go:"GO:0030496"(midbody)|go:"GO:0051233"(spindle midzone)|go:"GO:0051255"(spindle midzone assembly)	rgd:620966|refseq:NP_446339.1|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR007527(Zinc finger, SWIM-type)|go:"GO:0000165"(MAPK cascade)|interpro:IPR016024(Armadillo-type fold)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0002011"(morphogenesis of an epithelial sheet)|go:"GO:0003382"(epithelial cell morphogenesis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004706"(JUN kinase kinase kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007254"(JNK cascade)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008432"(JUN kinase binding)|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0016020"(membrane)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0031434"(mitogen-activated protein kinase kinase binding)|go:"GO:0031941"(filamentous actin)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0042060"(wound healing)|go:"GO:0043010"(camera-type eye development)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046625"(sphingolipid binding)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050434"(positive regulation of viral transcription)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0061029"(eyelid development in camera-type eye)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|reactome:R-RNO-166058|reactome:R-RNO-2871796|reactome:R-RNO-975138|reactome:R-RNO-975871|interpro:IPR011989(Armadillo-like helical)|mint:Q62925	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S3|resulting-ptm:A6NI79 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:IC6SaRpdaGLfv9bD8aXbUZY7syU9606	rogid:EwhjYjowkZIAt4UyPcZBUtf9uak10116	intact-crc:4D55182EAEF56D38|rigid:K4JawJnoTUAy43fm8fn+0ibubjI	false	-	sufficient binding region:433-481(IPR013083)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:A6NI79	uniprotkb:Q13404	intact:EBI-5652866|uniprotkb:A8K9X6|ensembl:ENSP00000347586	intact:EBI-1050671|uniprotkb:Q13403|uniprotkb:Q13532|uniprotkb:Q96H34|uniprotkb:Q9GZT0|uniprotkb:Q9GZW1|uniprotkb:Q9H4J3|uniprotkb:Q9H4J4|uniprotkb:Q9UKL1|uniprotkb:Q9UM48|uniprotkb:Q9UM49|uniprotkb:Q9UM50|uniprotkb:Q5TGE3|uniprotkb:E1P629|uniprotkb:Q5TGE0|ensembl:ENSP00000360739	psi-mi:ccd69_human(display_long)|uniprotkb:CCDC69(gene name)|psi-mi:CCDC69(display_short)	psi-mi:ub2v1_human(display_long)|uniprotkb:CROC-1(gene name synonym)|uniprotkb:TRAF6-regulated IKK activator 1 beta Uev1A(gene name synonym)|uniprotkb:P/OKcl.19(orf name)|uniprotkb:UBE2V1(gene name)|psi-mi:UBE2V1(display_short)|uniprotkb:CROC1(gene name synonym)|uniprotkb:UBE2V(gene name synonym)|uniprotkb:UEV1(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9971233|imex:IM-22822-63	author-confidence:Z-score = 3.22	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_056436.2|ensembl:ENSG00000198624(gene)|ensembl:ENST00000355417(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0008017"(microtubule binding)|go:"GO:0030496"(midbody)|go:"GO:0051233"(spindle midzone)|go:"GO:0051255"(spindle midzone assembly)	refseq:NP_001027459.1|refseq:NP_068823.2|refseq:NP_071887.1|refseq:NP_954595.1|refseq:NP_954673.1|refseq:NP_001244322.1|refseq:NP_001244323.1|refseq:NP_001244325.1|ensembl:ENSG00000244687(gene)|ensembl:ENST00000371674(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006282"(regulation of DNA repair)|go:"GO:0006301"(postreplication repair)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0030154"(cell differentiation)|go:"GO:0031371"(ubiquitin conjugating enzyme complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035370"(UBC13-UEV1A complex)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070534"(protein K63-linked ubiquitination)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|rcsb pdb:2A4D|rcsb pdb:2C2V|rcsb pdb:2HLW|rcsb pdb:6D6I|reactome:R-HSA-168638|reactome:R-HSA-168927|reactome:R-HSA-202424|reactome:R-HSA-2871837|reactome:R-HSA-445989|reactome:R-HSA-450302|reactome:R-HSA-450321|reactome:R-HSA-5607764|reactome:R-HSA-9020702|reactome:R-HSA-937039|reactome:R-HSA-937041|reactome:R-HSA-9646399|reactome:R-HSA-975110|reactome:R-HSA-975144|reactome:R-HSA-983168|dip:DIP-41911N	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S3|resulting-ptm:A6NI79 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:IC6SaRpdaGLfv9bD8aXbUZY7syU9606	rogid:x95N7Dj2KIqu5gySX59xLmfthUg9606	intact-crc:4D55182EAEF56D38|rigid:K4JawJnoTUAy43fm8fn+0ibubjI	false	-	his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:A6NI79	uniprotkb:P22314	intact:EBI-5652866|uniprotkb:A8K9X6|ensembl:ENSP00000347586	intact:EBI-709688|uniprotkb:Q96E13|uniprotkb:Q5JRR8|ensembl:ENSP00000338413|ensembl:ENSP00000366568	psi-mi:ccd69_human(display_long)|uniprotkb:CCDC69(gene name)|psi-mi:CCDC69(display_short)	psi-mi:uba1_human(display_long)|uniprotkb:Ubiquitin-activating enzyme E1(gene name synonym)|uniprotkb:Protein A1S9(gene name synonym)|uniprotkb:UBA1(gene name)|psi-mi:UBA1(display_short)|uniprotkb:A1S9T(gene name synonym)|uniprotkb:UBE1(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9971233|imex:IM-22822-63	author-confidence:Z-score = 3.22	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_056436.2|ensembl:ENSG00000198624(gene)|ensembl:ENST00000355417(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0008017"(microtubule binding)|go:"GO:0030496"(midbody)|go:"GO:0051233"(spindle midzone)|go:"GO:0051255"(spindle midzone assembly)	refseq:NP_003325.2|refseq:NP_695012.1|refseq:XP_016885269.1|refseq:XP_016885270.1|dip:DIP-33686N|ensembl:ENSG00000130985(gene)|ensembl:ENST00000335972(transcript)|ensembl:ENST00000377351(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0004839"(ubiquitin activating enzyme activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0032446"(protein modification by small protein conjugation)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000011(Ubiquitin-activating enzyme, E1)|interpro:IPR000594(UBA/THIF-type NAD/FAD binding fold)|interpro:IPR018074|interpro:IPR018075|interpro:IPR018965|interpro:IPR019572|interpro:IPR032418|interpro:IPR032420|interpro:IPR033127|interpro:IPR035985|interpro:IPR038252|interpro:IPR042063|interpro:IPR042302|interpro:IPR042449|mint:P22314|rcsb pdb:4P22|rcsb pdb:6DC6|reactome:R-HSA-8866652|reactome:R-HSA-983168	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S3|resulting-ptm:A6NI79 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:IC6SaRpdaGLfv9bD8aXbUZY7syU9606	rogid:q+vEeA0XLST0Zz173bmEt0dNbDE9606	intact-crc:4D55182EAEF56D38|rigid:K4JawJnoTUAy43fm8fn+0ibubjI	false	-	his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:A6NI79	uniprotkb:P61088	intact:EBI-5652866|uniprotkb:A8K9X6|ensembl:ENSP00000347586	intact:EBI-1052908|uniprotkb:Q16781|uniprotkb:Q53Y81|ensembl:ENSP00000316176	psi-mi:ccd69_human(display_long)|uniprotkb:CCDC69(gene name)|psi-mi:CCDC69(display_short)	psi-mi:ube2n_human(display_long)|uniprotkb:Ubiquitin-protein ligase N(gene name synonym)|uniprotkb:Ubiquitin carrier protein N(gene name synonym)|uniprotkb:Ubc13(gene name synonym)|uniprotkb:Bendless-like ubiquitin-conjugating enzyme(gene name synonym)|uniprotkb:UBE2N(gene name)|psi-mi:UBE2N(display_short)|uniprotkb:BLU(gene name synonym)|uniprotkb:UbcH13(gene name synonym)|uniprotkb:E2 ubiquitin-conjugating enzyme N(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9971233|imex:IM-22822-63	author-confidence:Z-score = 3.22	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_056436.2|ensembl:ENSG00000198624(gene)|ensembl:ENST00000355417(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0008017"(microtubule binding)|go:"GO:0030496"(midbody)|go:"GO:0051233"(spindle midzone)|go:"GO:0051255"(spindle midzone assembly)	refseq:NP_003339.1|dip:DIP-29829N|ensembl:ENSG00000177889(gene)|ensembl:ENST00000318066(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000729"(DNA double-strand break processing)|go:"GO:0001650"(fibrillar center)|go:"GO:0003723"(RNA binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006282"(regulation of DNA repair)|go:"GO:0006301"(postreplication repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016574"(histone ubiquitination)|go:"GO:0031058"(positive regulation of histone modification)|go:"GO:0031372"(UBC13-MMS2 complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033182"(regulation of histone ubiquitination)|go:"GO:0035370"(UBC13-UEV1A complex)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0061631"(ubiquitin conjugating enzyme activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070534"(protein K63-linked ubiquitination)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|interpro:IPR023313|rcsb pdb:1J7D|rcsb pdb:2C2V|rcsb pdb:3HCT|rcsb pdb:3HCU|rcsb pdb:3VON|rcsb pdb:3W31|rcsb pdb:4DHI|rcsb pdb:4DHJ|rcsb pdb:4DHZ|rcsb pdb:4IP3|rcsb pdb:4NR3|rcsb pdb:4NRG|rcsb pdb:4NRI|rcsb pdb:4ONL|rcsb pdb:4ONM|rcsb pdb:4ONN|rcsb pdb:4ORH|rcsb pdb:4TKP|rcsb pdb:4WHV|rcsb pdb:5AIT|rcsb pdb:5AIU|rcsb pdb:5EYA|rcsb pdb:5H7S|rcsb pdb:5VNZ|rcsb pdb:5VO0|rcsb pdb:5YWR|rcsb pdb:6D6I|rcsb pdb:6JKY|rcsb pdb:6KFP|rcsb pdb:6KG6|rcsb pdb:6KL4|rcsb pdb:6LP2|rcsb pdb:6P5B|rcsb pdb:6S53|reactome:R-HSA-168927|reactome:R-HSA-202424|reactome:R-HSA-2871837|reactome:R-HSA-445989|reactome:R-HSA-450302|reactome:R-HSA-450321|reactome:R-HSA-5607764|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-5696395|reactome:R-HSA-69473|reactome:R-HSA-8866654|reactome:R-HSA-9020702|reactome:R-HSA-937039|reactome:R-HSA-937041|reactome:R-HSA-9646399|reactome:R-HSA-975110|reactome:R-HSA-975144|reactome:R-HSA-983168|rcsb pdb:6ULH|rcsb pdb:6UMP|rcsb pdb:6UMS|rcsb pdb:7BBD|rcsb pdb:7BBF|rcsb pdb:7BXG|reactome:R-HSA-1169408|reactome:R-HSA-168638	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S3|resulting-ptm:A6NI79 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:IC6SaRpdaGLfv9bD8aXbUZY7syU9606	rogid:dqdszHlq5FLPHC6UWX6uvkC6Yz89606	intact-crc:4D55182EAEF56D38|rigid:K4JawJnoTUAy43fm8fn+0ibubjI	false	-	his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O00291	uniprotkb:Q62925	intact:EBI-473886|uniprotkb:O00328|uniprotkb:Q8TDL4|uniprotkb:Q2TB58|uniprotkb:V5LU97|uniprotkb:B4E3I7|uniprotkb:E7ES17|ensembl:ENSP00000336747	intact:EBI-636664	psi-mi:hip1_human(display_long)|uniprotkb:HIP1(gene name)|psi-mi:HIP1(display_short)|uniprotkb:Huntingtin-interacting protein I(gene name synonym)	psi-mi:m3k1_rat(display_long)|uniprotkb:MAPK/ERK kinase kinase 1(gene name synonym)|uniprotkb:Map3k1(gene name)|psi-mi:Map3k1(display_short)|uniprotkb:Mekk(gene name synonym)|uniprotkb:Mekk1(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9971284|imex:IM-22822-65	author-confidence:Z-score = 10.76	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0051015"(actin filament binding)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0072583"(clathrin-dependent endocytosis)|go:"GO:0080025"(phosphatidylinositol-3,5-bisphosphate binding)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098888"(extrinsic component of presynaptic membrane)|go:"GO:0098890"(extrinsic component of postsynaptic membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099637"(neurotransmitter receptor transport)|go:"GO:2000588"(positive regulation of platelet-derived growth factor receptor-beta signaling pathway)|interpro:IPR002558(I/LWEQ)|interpro:IPR008942(ENTH/VHS)|interpro:IPR011417(ANTH)|interpro:IPR013809(Epsin-like, N-terminal)|interpro:IPR030224|interpro:IPR030554|interpro:IPR032422|interpro:IPR035964|mint:O00291|rcsb pdb:2NO2|rcsb pdb:2QA7|rcsb pdb:3I00|reactome:R-HSA-8856828|refseq:NP_005329.3|refseq:NP_001230127.1|refseq:XP_005250361.1|refseq:XP_011514418.1|ensembl:ENSG00000127946(gene)|ensembl:ENST00000336926(transcript)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006897"(endocytosis)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007015"(actin filament organization)|go:"GO:0016020"(membrane)|go:"GO:0030100"(regulation of endocytosis)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030154"(cell differentiation)|go:"GO:0030276"(clathrin binding)|go:"GO:0030665"(clathrin-coated vesicle membrane)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032051"(clathrin light chain binding)|go:"GO:0032266"(phosphatidylinositol-3-phosphate binding)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0035612"(AP-2 adaptor complex binding)|go:"GO:0035615"(clathrin adaptor activity)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043325"(phosphatidylinositol-3,4-bisphosphate binding)|go:"GO:0045742"(positive regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048260"(positive regulation of receptor-mediated endocytosis)|go:"GO:0048268"(clathrin coat assembly)|go:"GO:0050821"(protein stabilization)|dip:DIP-17041N	rgd:620966|refseq:NP_446339.1|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR007527(Zinc finger, SWIM-type)|go:"GO:0000165"(MAPK cascade)|interpro:IPR016024(Armadillo-type fold)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0002011"(morphogenesis of an epithelial sheet)|go:"GO:0003382"(epithelial cell morphogenesis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004706"(JUN kinase kinase kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007254"(JNK cascade)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008432"(JUN kinase binding)|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0016020"(membrane)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0031434"(mitogen-activated protein kinase kinase binding)|go:"GO:0031941"(filamentous actin)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0042060"(wound healing)|go:"GO:0043010"(camera-type eye development)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046625"(sphingolipid binding)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050434"(positive regulation of viral transcription)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0061029"(eyelid development in camera-type eye)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|reactome:R-RNO-166058|reactome:R-RNO-2871796|reactome:R-RNO-975138|reactome:R-RNO-975871|interpro:IPR011989(Armadillo-like helical)|mint:Q62925	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S3|resulting-ptm:O00291 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:tv7gJyUeUPo98+42G8L980EnE/c9606	rogid:EwhjYjowkZIAt4UyPcZBUtf9uak10116	intact-crc:1135AEDDFEEE9934|rigid:EzusNMqyv6gxz5PGrrO8NXbCUTE	false	-	sufficient binding region:433-481(IPR013083)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O00291	uniprotkb:Q13404	intact:EBI-473886|uniprotkb:O00328|uniprotkb:Q8TDL4|uniprotkb:Q2TB58|uniprotkb:V5LU97|uniprotkb:B4E3I7|uniprotkb:E7ES17|ensembl:ENSP00000336747	intact:EBI-1050671|uniprotkb:Q13403|uniprotkb:Q13532|uniprotkb:Q96H34|uniprotkb:Q9GZT0|uniprotkb:Q9GZW1|uniprotkb:Q9H4J3|uniprotkb:Q9H4J4|uniprotkb:Q9UKL1|uniprotkb:Q9UM48|uniprotkb:Q9UM49|uniprotkb:Q9UM50|uniprotkb:Q5TGE3|uniprotkb:E1P629|uniprotkb:Q5TGE0|ensembl:ENSP00000360739	psi-mi:hip1_human(display_long)|uniprotkb:HIP1(gene name)|psi-mi:HIP1(display_short)|uniprotkb:Huntingtin-interacting protein I(gene name synonym)	psi-mi:ub2v1_human(display_long)|uniprotkb:CROC-1(gene name synonym)|uniprotkb:TRAF6-regulated IKK activator 1 beta Uev1A(gene name synonym)|uniprotkb:P/OKcl.19(orf name)|uniprotkb:UBE2V1(gene name)|psi-mi:UBE2V1(display_short)|uniprotkb:CROC1(gene name synonym)|uniprotkb:UBE2V(gene name synonym)|uniprotkb:UEV1(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9971284|imex:IM-22822-65	author-confidence:Z-score = 10.76	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0051015"(actin filament binding)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0072583"(clathrin-dependent endocytosis)|go:"GO:0080025"(phosphatidylinositol-3,5-bisphosphate binding)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098888"(extrinsic component of presynaptic membrane)|go:"GO:0098890"(extrinsic component of postsynaptic membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099637"(neurotransmitter receptor transport)|go:"GO:2000588"(positive regulation of platelet-derived growth factor receptor-beta signaling pathway)|interpro:IPR002558(I/LWEQ)|interpro:IPR008942(ENTH/VHS)|interpro:IPR011417(ANTH)|interpro:IPR013809(Epsin-like, N-terminal)|interpro:IPR030224|interpro:IPR030554|interpro:IPR032422|interpro:IPR035964|mint:O00291|rcsb pdb:2NO2|rcsb pdb:2QA7|rcsb pdb:3I00|reactome:R-HSA-8856828|refseq:NP_005329.3|refseq:NP_001230127.1|refseq:XP_005250361.1|refseq:XP_011514418.1|ensembl:ENSG00000127946(gene)|ensembl:ENST00000336926(transcript)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006897"(endocytosis)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007015"(actin filament organization)|go:"GO:0016020"(membrane)|go:"GO:0030100"(regulation of endocytosis)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030154"(cell differentiation)|go:"GO:0030276"(clathrin binding)|go:"GO:0030665"(clathrin-coated vesicle membrane)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032051"(clathrin light chain binding)|go:"GO:0032266"(phosphatidylinositol-3-phosphate binding)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0035612"(AP-2 adaptor complex binding)|go:"GO:0035615"(clathrin adaptor activity)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043325"(phosphatidylinositol-3,4-bisphosphate binding)|go:"GO:0045742"(positive regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048260"(positive regulation of receptor-mediated endocytosis)|go:"GO:0048268"(clathrin coat assembly)|go:"GO:0050821"(protein stabilization)|dip:DIP-17041N	refseq:NP_001027459.1|refseq:NP_068823.2|refseq:NP_071887.1|refseq:NP_954595.1|refseq:NP_954673.1|refseq:NP_001244322.1|refseq:NP_001244323.1|refseq:NP_001244325.1|ensembl:ENSG00000244687(gene)|ensembl:ENST00000371674(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006282"(regulation of DNA repair)|go:"GO:0006301"(postreplication repair)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0030154"(cell differentiation)|go:"GO:0031371"(ubiquitin conjugating enzyme complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035370"(UBC13-UEV1A complex)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070534"(protein K63-linked ubiquitination)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|rcsb pdb:2A4D|rcsb pdb:2C2V|rcsb pdb:2HLW|rcsb pdb:6D6I|reactome:R-HSA-168638|reactome:R-HSA-168927|reactome:R-HSA-202424|reactome:R-HSA-2871837|reactome:R-HSA-445989|reactome:R-HSA-450302|reactome:R-HSA-450321|reactome:R-HSA-5607764|reactome:R-HSA-9020702|reactome:R-HSA-937039|reactome:R-HSA-937041|reactome:R-HSA-9646399|reactome:R-HSA-975110|reactome:R-HSA-975144|reactome:R-HSA-983168|dip:DIP-41911N	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S3|resulting-ptm:O00291 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:tv7gJyUeUPo98+42G8L980EnE/c9606	rogid:x95N7Dj2KIqu5gySX59xLmfthUg9606	intact-crc:1135AEDDFEEE9934|rigid:EzusNMqyv6gxz5PGrrO8NXbCUTE	false	-	his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O00291	uniprotkb:P22314	intact:EBI-473886|uniprotkb:O00328|uniprotkb:Q8TDL4|uniprotkb:Q2TB58|uniprotkb:V5LU97|uniprotkb:B4E3I7|uniprotkb:E7ES17|ensembl:ENSP00000336747	intact:EBI-709688|uniprotkb:Q96E13|uniprotkb:Q5JRR8|ensembl:ENSP00000338413|ensembl:ENSP00000366568	psi-mi:hip1_human(display_long)|uniprotkb:HIP1(gene name)|psi-mi:HIP1(display_short)|uniprotkb:Huntingtin-interacting protein I(gene name synonym)	psi-mi:uba1_human(display_long)|uniprotkb:Ubiquitin-activating enzyme E1(gene name synonym)|uniprotkb:Protein A1S9(gene name synonym)|uniprotkb:UBA1(gene name)|psi-mi:UBA1(display_short)|uniprotkb:A1S9T(gene name synonym)|uniprotkb:UBE1(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9971284|imex:IM-22822-65	author-confidence:Z-score = 10.76	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0051015"(actin filament binding)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0072583"(clathrin-dependent endocytosis)|go:"GO:0080025"(phosphatidylinositol-3,5-bisphosphate binding)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098888"(extrinsic component of presynaptic membrane)|go:"GO:0098890"(extrinsic component of postsynaptic membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099637"(neurotransmitter receptor transport)|go:"GO:2000588"(positive regulation of platelet-derived growth factor receptor-beta signaling pathway)|interpro:IPR002558(I/LWEQ)|interpro:IPR008942(ENTH/VHS)|interpro:IPR011417(ANTH)|interpro:IPR013809(Epsin-like, N-terminal)|interpro:IPR030224|interpro:IPR030554|interpro:IPR032422|interpro:IPR035964|mint:O00291|rcsb pdb:2NO2|rcsb pdb:2QA7|rcsb pdb:3I00|reactome:R-HSA-8856828|refseq:NP_005329.3|refseq:NP_001230127.1|refseq:XP_005250361.1|refseq:XP_011514418.1|ensembl:ENSG00000127946(gene)|ensembl:ENST00000336926(transcript)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006897"(endocytosis)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007015"(actin filament organization)|go:"GO:0016020"(membrane)|go:"GO:0030100"(regulation of endocytosis)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030154"(cell differentiation)|go:"GO:0030276"(clathrin binding)|go:"GO:0030665"(clathrin-coated vesicle membrane)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032051"(clathrin light chain binding)|go:"GO:0032266"(phosphatidylinositol-3-phosphate binding)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0035612"(AP-2 adaptor complex binding)|go:"GO:0035615"(clathrin adaptor activity)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043325"(phosphatidylinositol-3,4-bisphosphate binding)|go:"GO:0045742"(positive regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048260"(positive regulation of receptor-mediated endocytosis)|go:"GO:0048268"(clathrin coat assembly)|go:"GO:0050821"(protein stabilization)|dip:DIP-17041N	refseq:NP_003325.2|refseq:NP_695012.1|refseq:XP_016885269.1|refseq:XP_016885270.1|dip:DIP-33686N|ensembl:ENSG00000130985(gene)|ensembl:ENST00000335972(transcript)|ensembl:ENST00000377351(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0004839"(ubiquitin activating enzyme activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0032446"(protein modification by small protein conjugation)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000011(Ubiquitin-activating enzyme, E1)|interpro:IPR000594(UBA/THIF-type NAD/FAD binding fold)|interpro:IPR018074|interpro:IPR018075|interpro:IPR018965|interpro:IPR019572|interpro:IPR032418|interpro:IPR032420|interpro:IPR033127|interpro:IPR035985|interpro:IPR038252|interpro:IPR042063|interpro:IPR042302|interpro:IPR042449|mint:P22314|rcsb pdb:4P22|rcsb pdb:6DC6|reactome:R-HSA-8866652|reactome:R-HSA-983168	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S3|resulting-ptm:O00291 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:tv7gJyUeUPo98+42G8L980EnE/c9606	rogid:q+vEeA0XLST0Zz173bmEt0dNbDE9606	intact-crc:1135AEDDFEEE9934|rigid:EzusNMqyv6gxz5PGrrO8NXbCUTE	false	-	his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O00291	uniprotkb:P61088	intact:EBI-473886|uniprotkb:O00328|uniprotkb:Q8TDL4|uniprotkb:Q2TB58|uniprotkb:V5LU97|uniprotkb:B4E3I7|uniprotkb:E7ES17|ensembl:ENSP00000336747	intact:EBI-1052908|uniprotkb:Q16781|uniprotkb:Q53Y81|ensembl:ENSP00000316176	psi-mi:hip1_human(display_long)|uniprotkb:HIP1(gene name)|psi-mi:HIP1(display_short)|uniprotkb:Huntingtin-interacting protein I(gene name synonym)	psi-mi:ube2n_human(display_long)|uniprotkb:Ubiquitin-protein ligase N(gene name synonym)|uniprotkb:Ubiquitin carrier protein N(gene name synonym)|uniprotkb:Ubc13(gene name synonym)|uniprotkb:Bendless-like ubiquitin-conjugating enzyme(gene name synonym)|uniprotkb:UBE2N(gene name)|psi-mi:UBE2N(display_short)|uniprotkb:BLU(gene name synonym)|uniprotkb:UbcH13(gene name synonym)|uniprotkb:E2 ubiquitin-conjugating enzyme N(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9971284|imex:IM-22822-65	author-confidence:Z-score = 10.76	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0051015"(actin filament binding)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0072583"(clathrin-dependent endocytosis)|go:"GO:0080025"(phosphatidylinositol-3,5-bisphosphate binding)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098888"(extrinsic component of presynaptic membrane)|go:"GO:0098890"(extrinsic component of postsynaptic membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099637"(neurotransmitter receptor transport)|go:"GO:2000588"(positive regulation of platelet-derived growth factor receptor-beta signaling pathway)|interpro:IPR002558(I/LWEQ)|interpro:IPR008942(ENTH/VHS)|interpro:IPR011417(ANTH)|interpro:IPR013809(Epsin-like, N-terminal)|interpro:IPR030224|interpro:IPR030554|interpro:IPR032422|interpro:IPR035964|mint:O00291|rcsb pdb:2NO2|rcsb pdb:2QA7|rcsb pdb:3I00|reactome:R-HSA-8856828|refseq:NP_005329.3|refseq:NP_001230127.1|refseq:XP_005250361.1|refseq:XP_011514418.1|ensembl:ENSG00000127946(gene)|ensembl:ENST00000336926(transcript)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006897"(endocytosis)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007015"(actin filament organization)|go:"GO:0016020"(membrane)|go:"GO:0030100"(regulation of endocytosis)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030154"(cell differentiation)|go:"GO:0030276"(clathrin binding)|go:"GO:0030665"(clathrin-coated vesicle membrane)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032051"(clathrin light chain binding)|go:"GO:0032266"(phosphatidylinositol-3-phosphate binding)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0035612"(AP-2 adaptor complex binding)|go:"GO:0035615"(clathrin adaptor activity)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043325"(phosphatidylinositol-3,4-bisphosphate binding)|go:"GO:0045742"(positive regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048260"(positive regulation of receptor-mediated endocytosis)|go:"GO:0048268"(clathrin coat assembly)|go:"GO:0050821"(protein stabilization)|dip:DIP-17041N	refseq:NP_003339.1|dip:DIP-29829N|ensembl:ENSG00000177889(gene)|ensembl:ENST00000318066(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000729"(DNA double-strand break processing)|go:"GO:0001650"(fibrillar center)|go:"GO:0003723"(RNA binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006282"(regulation of DNA repair)|go:"GO:0006301"(postreplication repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016574"(histone ubiquitination)|go:"GO:0031058"(positive regulation of histone modification)|go:"GO:0031372"(UBC13-MMS2 complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033182"(regulation of histone ubiquitination)|go:"GO:0035370"(UBC13-UEV1A complex)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0061631"(ubiquitin conjugating enzyme activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070534"(protein K63-linked ubiquitination)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|interpro:IPR023313|rcsb pdb:1J7D|rcsb pdb:2C2V|rcsb pdb:3HCT|rcsb pdb:3HCU|rcsb pdb:3VON|rcsb pdb:3W31|rcsb pdb:4DHI|rcsb pdb:4DHJ|rcsb pdb:4DHZ|rcsb pdb:4IP3|rcsb pdb:4NR3|rcsb pdb:4NRG|rcsb pdb:4NRI|rcsb pdb:4ONL|rcsb pdb:4ONM|rcsb pdb:4ONN|rcsb pdb:4ORH|rcsb pdb:4TKP|rcsb pdb:4WHV|rcsb pdb:5AIT|rcsb pdb:5AIU|rcsb pdb:5EYA|rcsb pdb:5H7S|rcsb pdb:5VNZ|rcsb pdb:5VO0|rcsb pdb:5YWR|rcsb pdb:6D6I|rcsb pdb:6JKY|rcsb pdb:6KFP|rcsb pdb:6KG6|rcsb pdb:6KL4|rcsb pdb:6LP2|rcsb pdb:6P5B|rcsb pdb:6S53|reactome:R-HSA-168927|reactome:R-HSA-202424|reactome:R-HSA-2871837|reactome:R-HSA-445989|reactome:R-HSA-450302|reactome:R-HSA-450321|reactome:R-HSA-5607764|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-5696395|reactome:R-HSA-69473|reactome:R-HSA-8866654|reactome:R-HSA-9020702|reactome:R-HSA-937039|reactome:R-HSA-937041|reactome:R-HSA-9646399|reactome:R-HSA-975110|reactome:R-HSA-975144|reactome:R-HSA-983168|rcsb pdb:6ULH|rcsb pdb:6UMP|rcsb pdb:6UMS|rcsb pdb:7BBD|rcsb pdb:7BBF|rcsb pdb:7BXG|reactome:R-HSA-1169408|reactome:R-HSA-168638	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S3|resulting-ptm:O00291 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:tv7gJyUeUPo98+42G8L980EnE/c9606	rogid:dqdszHlq5FLPHC6UWX6uvkC6Yz89606	intact-crc:1135AEDDFEEE9934|rigid:EzusNMqyv6gxz5PGrrO8NXbCUTE	false	-	his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q62925	uniprotkb:O14730	intact:EBI-636664	intact:EBI-1047061|uniprotkb:Q8IXN9|ensembl:ENSP00000341874	psi-mi:m3k1_rat(display_long)|uniprotkb:MAPK/ERK kinase kinase 1(gene name synonym)|uniprotkb:Map3k1(gene name)|psi-mi:Map3k1(display_short)|uniprotkb:Mekk(gene name synonym)|uniprotkb:Mekk1(gene name synonym)	psi-mi:riok3_human(display_long)|uniprotkb:sudD homolog(gene name synonym)|uniprotkb:RIOK3(gene name)|psi-mi:RIOK3(display_short)|uniprotkb:SUDD(gene name synonym)|uniprotkb:RIO kinase 3(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9971309|imex:IM-22822-66	author-confidence:Z-score = 10.78	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:620966|refseq:NP_446339.1|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR007527(Zinc finger, SWIM-type)|go:"GO:0000165"(MAPK cascade)|interpro:IPR016024(Armadillo-type fold)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0002011"(morphogenesis of an epithelial sheet)|go:"GO:0003382"(epithelial cell morphogenesis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004706"(JUN kinase kinase kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007254"(JNK cascade)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008432"(JUN kinase binding)|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0016020"(membrane)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0031434"(mitogen-activated protein kinase kinase binding)|go:"GO:0031941"(filamentous actin)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0042060"(wound healing)|go:"GO:0043010"(camera-type eye development)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046625"(sphingolipid binding)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050434"(positive regulation of viral transcription)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0061029"(eyelid development in camera-type eye)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|reactome:R-RNO-166058|reactome:R-RNO-2871796|reactome:R-RNO-975138|reactome:R-RNO-975871|interpro:IPR011989(Armadillo-like helical)|mint:Q62925	refseq:NP_003822.2|ensembl:ENSG00000101782(gene)|ensembl:ENST00000339486(transcript)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0007059"(chromosome segregation)|go:"GO:0030490"(maturation of SSU-rRNA)|go:"GO:0030688"(preribosome, small subunit precursor)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0039534"(negative regulation of MDA-5 signaling pathway)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045087"(innate immune response)|go:"GO:0045089"(positive regulation of innate immune response)|go:"GO:0046872"(metal ion binding)|go:"GO:0051607"(defense response to virus)|go:"GO:0071359"(cellular response to dsRNA)|go:"GO:0089720"(caspase binding)|go:"GO:0098586"(cellular response to virus)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1990786"(cellular response to dsDNA)|interpro:IPR000687(RIO kinase)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017406(Serine/threonine-protein kinase Rio3)|interpro:IPR018935|reactome:R-HSA-6791226	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S3|resulting-ptm:O14730 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:EwhjYjowkZIAt4UyPcZBUtf9uak10116	rogid:pC/TdpTG0HK/d1F4KIIpU3bzTcg9606	intact-crc:CFE617E8D665746B|rigid:iLpgZ+0J9BWB1Tc7YwGy3MV1pVE	false	sufficient binding region:433-481(IPR013083)	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q62925	uniprotkb:Q13404	intact:EBI-636664	intact:EBI-1050671|uniprotkb:Q13403|uniprotkb:Q13532|uniprotkb:Q96H34|uniprotkb:Q9GZT0|uniprotkb:Q9GZW1|uniprotkb:Q9H4J3|uniprotkb:Q9H4J4|uniprotkb:Q9UKL1|uniprotkb:Q9UM48|uniprotkb:Q9UM49|uniprotkb:Q9UM50|uniprotkb:Q5TGE3|uniprotkb:E1P629|uniprotkb:Q5TGE0|ensembl:ENSP00000360739	psi-mi:m3k1_rat(display_long)|uniprotkb:MAPK/ERK kinase kinase 1(gene name synonym)|uniprotkb:Map3k1(gene name)|psi-mi:Map3k1(display_short)|uniprotkb:Mekk(gene name synonym)|uniprotkb:Mekk1(gene name synonym)	psi-mi:ub2v1_human(display_long)|uniprotkb:CROC-1(gene name synonym)|uniprotkb:TRAF6-regulated IKK activator 1 beta Uev1A(gene name synonym)|uniprotkb:P/OKcl.19(orf name)|uniprotkb:UBE2V1(gene name)|psi-mi:UBE2V1(display_short)|uniprotkb:CROC1(gene name synonym)|uniprotkb:UBE2V(gene name synonym)|uniprotkb:UEV1(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9971309|imex:IM-22822-66	author-confidence:Z-score = 10.78	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:620966|refseq:NP_446339.1|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR007527(Zinc finger, SWIM-type)|go:"GO:0000165"(MAPK cascade)|interpro:IPR016024(Armadillo-type fold)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0002011"(morphogenesis of an epithelial sheet)|go:"GO:0003382"(epithelial cell morphogenesis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004706"(JUN kinase kinase kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007254"(JNK cascade)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008432"(JUN kinase binding)|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0016020"(membrane)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0031434"(mitogen-activated protein kinase kinase binding)|go:"GO:0031941"(filamentous actin)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0042060"(wound healing)|go:"GO:0043010"(camera-type eye development)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046625"(sphingolipid binding)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050434"(positive regulation of viral transcription)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0061029"(eyelid development in camera-type eye)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|reactome:R-RNO-166058|reactome:R-RNO-2871796|reactome:R-RNO-975138|reactome:R-RNO-975871|interpro:IPR011989(Armadillo-like helical)|mint:Q62925	refseq:NP_001027459.1|refseq:NP_068823.2|refseq:NP_071887.1|refseq:NP_954595.1|refseq:NP_954673.1|refseq:NP_001244322.1|refseq:NP_001244323.1|refseq:NP_001244325.1|ensembl:ENSG00000244687(gene)|ensembl:ENST00000371674(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006282"(regulation of DNA repair)|go:"GO:0006301"(postreplication repair)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0030154"(cell differentiation)|go:"GO:0031371"(ubiquitin conjugating enzyme complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035370"(UBC13-UEV1A complex)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070534"(protein K63-linked ubiquitination)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|rcsb pdb:2A4D|rcsb pdb:2C2V|rcsb pdb:2HLW|rcsb pdb:6D6I|reactome:R-HSA-168638|reactome:R-HSA-168927|reactome:R-HSA-202424|reactome:R-HSA-2871837|reactome:R-HSA-445989|reactome:R-HSA-450302|reactome:R-HSA-450321|reactome:R-HSA-5607764|reactome:R-HSA-9020702|reactome:R-HSA-937039|reactome:R-HSA-937041|reactome:R-HSA-9646399|reactome:R-HSA-975110|reactome:R-HSA-975144|reactome:R-HSA-983168|dip:DIP-41911N	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S3|resulting-ptm:O14730 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:EwhjYjowkZIAt4UyPcZBUtf9uak10116	rogid:x95N7Dj2KIqu5gySX59xLmfthUg9606	intact-crc:CFE617E8D665746B|rigid:iLpgZ+0J9BWB1Tc7YwGy3MV1pVE	false	sufficient binding region:433-481(IPR013083)	his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q62925	uniprotkb:P22314	intact:EBI-636664	intact:EBI-709688|uniprotkb:Q96E13|uniprotkb:Q5JRR8|ensembl:ENSP00000338413|ensembl:ENSP00000366568	psi-mi:m3k1_rat(display_long)|uniprotkb:MAPK/ERK kinase kinase 1(gene name synonym)|uniprotkb:Map3k1(gene name)|psi-mi:Map3k1(display_short)|uniprotkb:Mekk(gene name synonym)|uniprotkb:Mekk1(gene name synonym)	psi-mi:uba1_human(display_long)|uniprotkb:Ubiquitin-activating enzyme E1(gene name synonym)|uniprotkb:Protein A1S9(gene name synonym)|uniprotkb:UBA1(gene name)|psi-mi:UBA1(display_short)|uniprotkb:A1S9T(gene name synonym)|uniprotkb:UBE1(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9971309|imex:IM-22822-66	author-confidence:Z-score = 10.78	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:620966|refseq:NP_446339.1|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR007527(Zinc finger, SWIM-type)|go:"GO:0000165"(MAPK cascade)|interpro:IPR016024(Armadillo-type fold)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0002011"(morphogenesis of an epithelial sheet)|go:"GO:0003382"(epithelial cell morphogenesis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004706"(JUN kinase kinase kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007254"(JNK cascade)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008432"(JUN kinase binding)|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0016020"(membrane)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0031434"(mitogen-activated protein kinase kinase binding)|go:"GO:0031941"(filamentous actin)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0042060"(wound healing)|go:"GO:0043010"(camera-type eye development)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046625"(sphingolipid binding)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050434"(positive regulation of viral transcription)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0061029"(eyelid development in camera-type eye)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|reactome:R-RNO-166058|reactome:R-RNO-2871796|reactome:R-RNO-975138|reactome:R-RNO-975871|interpro:IPR011989(Armadillo-like helical)|mint:Q62925	refseq:NP_003325.2|refseq:NP_695012.1|refseq:XP_016885269.1|refseq:XP_016885270.1|dip:DIP-33686N|ensembl:ENSG00000130985(gene)|ensembl:ENST00000335972(transcript)|ensembl:ENST00000377351(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0004839"(ubiquitin activating enzyme activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0032446"(protein modification by small protein conjugation)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000011(Ubiquitin-activating enzyme, E1)|interpro:IPR000594(UBA/THIF-type NAD/FAD binding fold)|interpro:IPR018074|interpro:IPR018075|interpro:IPR018965|interpro:IPR019572|interpro:IPR032418|interpro:IPR032420|interpro:IPR033127|interpro:IPR035985|interpro:IPR038252|interpro:IPR042063|interpro:IPR042302|interpro:IPR042449|mint:P22314|rcsb pdb:4P22|rcsb pdb:6DC6|reactome:R-HSA-8866652|reactome:R-HSA-983168	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S3|resulting-ptm:O14730 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:EwhjYjowkZIAt4UyPcZBUtf9uak10116	rogid:q+vEeA0XLST0Zz173bmEt0dNbDE9606	intact-crc:CFE617E8D665746B|rigid:iLpgZ+0J9BWB1Tc7YwGy3MV1pVE	false	sufficient binding region:433-481(IPR013083)	his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q62925	uniprotkb:P61088	intact:EBI-636664	intact:EBI-1052908|uniprotkb:Q16781|uniprotkb:Q53Y81|ensembl:ENSP00000316176	psi-mi:m3k1_rat(display_long)|uniprotkb:MAPK/ERK kinase kinase 1(gene name synonym)|uniprotkb:Map3k1(gene name)|psi-mi:Map3k1(display_short)|uniprotkb:Mekk(gene name synonym)|uniprotkb:Mekk1(gene name synonym)	psi-mi:ube2n_human(display_long)|uniprotkb:Ubiquitin-protein ligase N(gene name synonym)|uniprotkb:Ubiquitin carrier protein N(gene name synonym)|uniprotkb:Ubc13(gene name synonym)|uniprotkb:Bendless-like ubiquitin-conjugating enzyme(gene name synonym)|uniprotkb:UBE2N(gene name)|psi-mi:UBE2N(display_short)|uniprotkb:BLU(gene name synonym)|uniprotkb:UbcH13(gene name synonym)|uniprotkb:E2 ubiquitin-conjugating enzyme N(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9971309|imex:IM-22822-66	author-confidence:Z-score = 10.78	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:620966|refseq:NP_446339.1|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR007527(Zinc finger, SWIM-type)|go:"GO:0000165"(MAPK cascade)|interpro:IPR016024(Armadillo-type fold)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0002011"(morphogenesis of an epithelial sheet)|go:"GO:0003382"(epithelial cell morphogenesis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004706"(JUN kinase kinase kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007254"(JNK cascade)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008432"(JUN kinase binding)|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0016020"(membrane)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0031434"(mitogen-activated protein kinase kinase binding)|go:"GO:0031941"(filamentous actin)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0042060"(wound healing)|go:"GO:0043010"(camera-type eye development)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046625"(sphingolipid binding)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050434"(positive regulation of viral transcription)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0061029"(eyelid development in camera-type eye)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|reactome:R-RNO-166058|reactome:R-RNO-2871796|reactome:R-RNO-975138|reactome:R-RNO-975871|interpro:IPR011989(Armadillo-like helical)|mint:Q62925	refseq:NP_003339.1|dip:DIP-29829N|ensembl:ENSG00000177889(gene)|ensembl:ENST00000318066(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000729"(DNA double-strand break processing)|go:"GO:0001650"(fibrillar center)|go:"GO:0003723"(RNA binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006282"(regulation of DNA repair)|go:"GO:0006301"(postreplication repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016574"(histone ubiquitination)|go:"GO:0031058"(positive regulation of histone modification)|go:"GO:0031372"(UBC13-MMS2 complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033182"(regulation of histone ubiquitination)|go:"GO:0035370"(UBC13-UEV1A complex)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0061631"(ubiquitin conjugating enzyme activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070534"(protein K63-linked ubiquitination)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|interpro:IPR023313|rcsb pdb:1J7D|rcsb pdb:2C2V|rcsb pdb:3HCT|rcsb pdb:3HCU|rcsb pdb:3VON|rcsb pdb:3W31|rcsb pdb:4DHI|rcsb pdb:4DHJ|rcsb pdb:4DHZ|rcsb pdb:4IP3|rcsb pdb:4NR3|rcsb pdb:4NRG|rcsb pdb:4NRI|rcsb pdb:4ONL|rcsb pdb:4ONM|rcsb pdb:4ONN|rcsb pdb:4ORH|rcsb pdb:4TKP|rcsb pdb:4WHV|rcsb pdb:5AIT|rcsb pdb:5AIU|rcsb pdb:5EYA|rcsb pdb:5H7S|rcsb pdb:5VNZ|rcsb pdb:5VO0|rcsb pdb:5YWR|rcsb pdb:6D6I|rcsb pdb:6JKY|rcsb pdb:6KFP|rcsb pdb:6KG6|rcsb pdb:6KL4|rcsb pdb:6LP2|rcsb pdb:6P5B|rcsb pdb:6S53|reactome:R-HSA-168927|reactome:R-HSA-202424|reactome:R-HSA-2871837|reactome:R-HSA-445989|reactome:R-HSA-450302|reactome:R-HSA-450321|reactome:R-HSA-5607764|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-5696395|reactome:R-HSA-69473|reactome:R-HSA-8866654|reactome:R-HSA-9020702|reactome:R-HSA-937039|reactome:R-HSA-937041|reactome:R-HSA-9646399|reactome:R-HSA-975110|reactome:R-HSA-975144|reactome:R-HSA-983168|rcsb pdb:6ULH|rcsb pdb:6UMP|rcsb pdb:6UMS|rcsb pdb:7BBD|rcsb pdb:7BBF|rcsb pdb:7BXG|reactome:R-HSA-1169408|reactome:R-HSA-168638	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S3|resulting-ptm:O14730 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:EwhjYjowkZIAt4UyPcZBUtf9uak10116	rogid:dqdszHlq5FLPHC6UWX6uvkC6Yz89606	intact-crc:CFE617E8D665746B|rigid:iLpgZ+0J9BWB1Tc7YwGy3MV1pVE	false	sufficient binding region:433-481(IPR013083)	his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O14964	uniprotkb:Q62925	intact:EBI-740220|uniprotkb:Q9NR36|ensembl:ENSP00000331201|ensembl:ENSP00000504106	intact:EBI-636664	psi-mi:hgs_human(display_long)|uniprotkb:Protein pp110(gene name synonym)|uniprotkb:Hrs(gene name synonym)|uniprotkb:HGS(gene name)|psi-mi:HGS(display_short)|uniprotkb:HRS(gene name synonym)	psi-mi:m3k1_rat(display_long)|uniprotkb:MAPK/ERK kinase kinase 1(gene name synonym)|uniprotkb:Map3k1(gene name)|psi-mi:Map3k1(display_short)|uniprotkb:Mekk(gene name synonym)|uniprotkb:Mekk1(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9971334|imex:IM-22822-67	author-confidence:Z-score = 11.26	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_004703.1|dip:DIP-29050N|ensembl:ENSG00000185359(gene)|ensembl:ENST00000329138(transcript)|ensembl:ENST00000676546(transcript)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0006622"(protein targeting to lysosome)|go:"GO:0007165"(signal transduction)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010324"(membrane invagination)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010642"(negative regulation of platelet-derived growth factor receptor signaling pathway)|go:"GO:0016197"(endosomal transport)|go:"GO:0016236"(macroautophagy)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030948"(negative regulation of vascular endothelial growth factor receptor signaling pathway)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032585"(multivesicular body membrane)|go:"GO:0033565"(ESCRT-0 complex)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0036258"(multivesicular body assembly)|go:"GO:0042176"(regulation of protein catabolic process)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043405"(regulation of MAP kinase activity)|go:"GO:0044389"(ubiquitin-like protein ligase binding)|go:"GO:0046426"(negative regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0046872"(metal ion binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072657"(protein localization to membrane)|go:"GO:0097013"(phagocytic vesicle lumen)|go:"GO:1903543"(positive regulation of exosomal secretion)|interpro:IPR000306(Zinc finger, FYVE-type)|interpro:IPR002014(VHS)|interpro:IPR003903(Ubiquitin interacting motif)|interpro:IPR008942(ENTH/VHS)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017073(Ubiquitin binding protein, Hrs/VPS27)|interpro:IPR017455(Zinc finger, FYVE-related)|interpro:IPR024641|mint:O14964|rcsb pdb:2D3G|rcsb pdb:3F1I|rcsb pdb:3OBQ|rcsb pdb:3ZYQ|rcsb pdb:4AVX|reactome:R-HSA-182971|reactome:R-HSA-432720|reactome:R-HSA-5689880|reactome:R-HSA-6807004|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-8875360|reactome:R-HSA-9013420|reactome:R-HSA-917729|reactome:R-HSA-9635644|reactome:R-HSA-9636383|reactome:R-HSA-9706019	rgd:620966|refseq:NP_446339.1|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR007527(Zinc finger, SWIM-type)|go:"GO:0000165"(MAPK cascade)|interpro:IPR016024(Armadillo-type fold)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0002011"(morphogenesis of an epithelial sheet)|go:"GO:0003382"(epithelial cell morphogenesis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004706"(JUN kinase kinase kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007254"(JNK cascade)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008432"(JUN kinase binding)|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0016020"(membrane)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0031434"(mitogen-activated protein kinase kinase binding)|go:"GO:0031941"(filamentous actin)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0042060"(wound healing)|go:"GO:0043010"(camera-type eye development)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046625"(sphingolipid binding)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050434"(positive regulation of viral transcription)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0061029"(eyelid development in camera-type eye)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|reactome:R-RNO-166058|reactome:R-RNO-2871796|reactome:R-RNO-975138|reactome:R-RNO-975871|interpro:IPR011989(Armadillo-like helical)|mint:Q62925	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S3|resulting-ptm:O14964 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:z/AnREuqEpyJ9/Zj6JFCJCJem1I9606	rogid:EwhjYjowkZIAt4UyPcZBUtf9uak10116	intact-crc:FFDEF4AC7B05FE7D|rigid:hO/vS27pQET2bE16aMAT5TtSNRM	false	-	sufficient binding region:433-481(IPR013083)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O14964	uniprotkb:Q13404	intact:EBI-740220|uniprotkb:Q9NR36|ensembl:ENSP00000331201|ensembl:ENSP00000504106	intact:EBI-1050671|uniprotkb:Q13403|uniprotkb:Q13532|uniprotkb:Q96H34|uniprotkb:Q9GZT0|uniprotkb:Q9GZW1|uniprotkb:Q9H4J3|uniprotkb:Q9H4J4|uniprotkb:Q9UKL1|uniprotkb:Q9UM48|uniprotkb:Q9UM49|uniprotkb:Q9UM50|uniprotkb:Q5TGE3|uniprotkb:E1P629|uniprotkb:Q5TGE0|ensembl:ENSP00000360739	psi-mi:hgs_human(display_long)|uniprotkb:Protein pp110(gene name synonym)|uniprotkb:Hrs(gene name synonym)|uniprotkb:HGS(gene name)|psi-mi:HGS(display_short)|uniprotkb:HRS(gene name synonym)	psi-mi:ub2v1_human(display_long)|uniprotkb:CROC-1(gene name synonym)|uniprotkb:TRAF6-regulated IKK activator 1 beta Uev1A(gene name synonym)|uniprotkb:P/OKcl.19(orf name)|uniprotkb:UBE2V1(gene name)|psi-mi:UBE2V1(display_short)|uniprotkb:CROC1(gene name synonym)|uniprotkb:UBE2V(gene name synonym)|uniprotkb:UEV1(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9971334|imex:IM-22822-67	author-confidence:Z-score = 11.26	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_004703.1|dip:DIP-29050N|ensembl:ENSG00000185359(gene)|ensembl:ENST00000329138(transcript)|ensembl:ENST00000676546(transcript)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0006622"(protein targeting to lysosome)|go:"GO:0007165"(signal transduction)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010324"(membrane invagination)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010642"(negative regulation of platelet-derived growth factor receptor signaling pathway)|go:"GO:0016197"(endosomal transport)|go:"GO:0016236"(macroautophagy)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030948"(negative regulation of vascular endothelial growth factor receptor signaling pathway)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032585"(multivesicular body membrane)|go:"GO:0033565"(ESCRT-0 complex)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0036258"(multivesicular body assembly)|go:"GO:0042176"(regulation of protein catabolic process)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043405"(regulation of MAP kinase activity)|go:"GO:0044389"(ubiquitin-like protein ligase binding)|go:"GO:0046426"(negative regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0046872"(metal ion binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072657"(protein localization to membrane)|go:"GO:0097013"(phagocytic vesicle lumen)|go:"GO:1903543"(positive regulation of exosomal secretion)|interpro:IPR000306(Zinc finger, FYVE-type)|interpro:IPR002014(VHS)|interpro:IPR003903(Ubiquitin interacting motif)|interpro:IPR008942(ENTH/VHS)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017073(Ubiquitin binding protein, Hrs/VPS27)|interpro:IPR017455(Zinc finger, FYVE-related)|interpro:IPR024641|mint:O14964|rcsb pdb:2D3G|rcsb pdb:3F1I|rcsb pdb:3OBQ|rcsb pdb:3ZYQ|rcsb pdb:4AVX|reactome:R-HSA-182971|reactome:R-HSA-432720|reactome:R-HSA-5689880|reactome:R-HSA-6807004|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-8875360|reactome:R-HSA-9013420|reactome:R-HSA-917729|reactome:R-HSA-9635644|reactome:R-HSA-9636383|reactome:R-HSA-9706019	refseq:NP_001027459.1|refseq:NP_068823.2|refseq:NP_071887.1|refseq:NP_954595.1|refseq:NP_954673.1|refseq:NP_001244322.1|refseq:NP_001244323.1|refseq:NP_001244325.1|ensembl:ENSG00000244687(gene)|ensembl:ENST00000371674(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006282"(regulation of DNA repair)|go:"GO:0006301"(postreplication repair)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0030154"(cell differentiation)|go:"GO:0031371"(ubiquitin conjugating enzyme complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035370"(UBC13-UEV1A complex)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070534"(protein K63-linked ubiquitination)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|rcsb pdb:2A4D|rcsb pdb:2C2V|rcsb pdb:2HLW|rcsb pdb:6D6I|reactome:R-HSA-168638|reactome:R-HSA-168927|reactome:R-HSA-202424|reactome:R-HSA-2871837|reactome:R-HSA-445989|reactome:R-HSA-450302|reactome:R-HSA-450321|reactome:R-HSA-5607764|reactome:R-HSA-9020702|reactome:R-HSA-937039|reactome:R-HSA-937041|reactome:R-HSA-9646399|reactome:R-HSA-975110|reactome:R-HSA-975144|reactome:R-HSA-983168|dip:DIP-41911N	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S3|resulting-ptm:O14964 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:z/AnREuqEpyJ9/Zj6JFCJCJem1I9606	rogid:x95N7Dj2KIqu5gySX59xLmfthUg9606	intact-crc:FFDEF4AC7B05FE7D|rigid:hO/vS27pQET2bE16aMAT5TtSNRM	false	-	his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O14964	uniprotkb:P22314	intact:EBI-740220|uniprotkb:Q9NR36|ensembl:ENSP00000331201|ensembl:ENSP00000504106	intact:EBI-709688|uniprotkb:Q96E13|uniprotkb:Q5JRR8|ensembl:ENSP00000338413|ensembl:ENSP00000366568	psi-mi:hgs_human(display_long)|uniprotkb:Protein pp110(gene name synonym)|uniprotkb:Hrs(gene name synonym)|uniprotkb:HGS(gene name)|psi-mi:HGS(display_short)|uniprotkb:HRS(gene name synonym)	psi-mi:uba1_human(display_long)|uniprotkb:Ubiquitin-activating enzyme E1(gene name synonym)|uniprotkb:Protein A1S9(gene name synonym)|uniprotkb:UBA1(gene name)|psi-mi:UBA1(display_short)|uniprotkb:A1S9T(gene name synonym)|uniprotkb:UBE1(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9971334|imex:IM-22822-67	author-confidence:Z-score = 11.26	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_004703.1|dip:DIP-29050N|ensembl:ENSG00000185359(gene)|ensembl:ENST00000329138(transcript)|ensembl:ENST00000676546(transcript)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0006622"(protein targeting to lysosome)|go:"GO:0007165"(signal transduction)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010324"(membrane invagination)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010642"(negative regulation of platelet-derived growth factor receptor signaling pathway)|go:"GO:0016197"(endosomal transport)|go:"GO:0016236"(macroautophagy)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030948"(negative regulation of vascular endothelial growth factor receptor signaling pathway)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032585"(multivesicular body membrane)|go:"GO:0033565"(ESCRT-0 complex)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0036258"(multivesicular body assembly)|go:"GO:0042176"(regulation of protein catabolic process)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043405"(regulation of MAP kinase activity)|go:"GO:0044389"(ubiquitin-like protein ligase binding)|go:"GO:0046426"(negative regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0046872"(metal ion binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072657"(protein localization to membrane)|go:"GO:0097013"(phagocytic vesicle lumen)|go:"GO:1903543"(positive regulation of exosomal secretion)|interpro:IPR000306(Zinc finger, FYVE-type)|interpro:IPR002014(VHS)|interpro:IPR003903(Ubiquitin interacting motif)|interpro:IPR008942(ENTH/VHS)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017073(Ubiquitin binding protein, Hrs/VPS27)|interpro:IPR017455(Zinc finger, FYVE-related)|interpro:IPR024641|mint:O14964|rcsb pdb:2D3G|rcsb pdb:3F1I|rcsb pdb:3OBQ|rcsb pdb:3ZYQ|rcsb pdb:4AVX|reactome:R-HSA-182971|reactome:R-HSA-432720|reactome:R-HSA-5689880|reactome:R-HSA-6807004|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-8875360|reactome:R-HSA-9013420|reactome:R-HSA-917729|reactome:R-HSA-9635644|reactome:R-HSA-9636383|reactome:R-HSA-9706019	refseq:NP_003325.2|refseq:NP_695012.1|refseq:XP_016885269.1|refseq:XP_016885270.1|dip:DIP-33686N|ensembl:ENSG00000130985(gene)|ensembl:ENST00000335972(transcript)|ensembl:ENST00000377351(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0004839"(ubiquitin activating enzyme activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0032446"(protein modification by small protein conjugation)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000011(Ubiquitin-activating enzyme, E1)|interpro:IPR000594(UBA/THIF-type NAD/FAD binding fold)|interpro:IPR018074|interpro:IPR018075|interpro:IPR018965|interpro:IPR019572|interpro:IPR032418|interpro:IPR032420|interpro:IPR033127|interpro:IPR035985|interpro:IPR038252|interpro:IPR042063|interpro:IPR042302|interpro:IPR042449|mint:P22314|rcsb pdb:4P22|rcsb pdb:6DC6|reactome:R-HSA-8866652|reactome:R-HSA-983168	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S3|resulting-ptm:O14964 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:z/AnREuqEpyJ9/Zj6JFCJCJem1I9606	rogid:q+vEeA0XLST0Zz173bmEt0dNbDE9606	intact-crc:FFDEF4AC7B05FE7D|rigid:hO/vS27pQET2bE16aMAT5TtSNRM	false	-	his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O14964	uniprotkb:P61088	intact:EBI-740220|uniprotkb:Q9NR36|ensembl:ENSP00000331201|ensembl:ENSP00000504106	intact:EBI-1052908|uniprotkb:Q16781|uniprotkb:Q53Y81|ensembl:ENSP00000316176	psi-mi:hgs_human(display_long)|uniprotkb:Protein pp110(gene name synonym)|uniprotkb:Hrs(gene name synonym)|uniprotkb:HGS(gene name)|psi-mi:HGS(display_short)|uniprotkb:HRS(gene name synonym)	psi-mi:ube2n_human(display_long)|uniprotkb:Ubiquitin-protein ligase N(gene name synonym)|uniprotkb:Ubiquitin carrier protein N(gene name synonym)|uniprotkb:Ubc13(gene name synonym)|uniprotkb:Bendless-like ubiquitin-conjugating enzyme(gene name synonym)|uniprotkb:UBE2N(gene name)|psi-mi:UBE2N(display_short)|uniprotkb:BLU(gene name synonym)|uniprotkb:UbcH13(gene name synonym)|uniprotkb:E2 ubiquitin-conjugating enzyme N(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9971334|imex:IM-22822-67	author-confidence:Z-score = 11.26	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_004703.1|dip:DIP-29050N|ensembl:ENSG00000185359(gene)|ensembl:ENST00000329138(transcript)|ensembl:ENST00000676546(transcript)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0006622"(protein targeting to lysosome)|go:"GO:0007165"(signal transduction)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010324"(membrane invagination)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010642"(negative regulation of platelet-derived growth factor receptor signaling pathway)|go:"GO:0016197"(endosomal transport)|go:"GO:0016236"(macroautophagy)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030948"(negative regulation of vascular endothelial growth factor receptor signaling pathway)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032585"(multivesicular body membrane)|go:"GO:0033565"(ESCRT-0 complex)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0036258"(multivesicular body assembly)|go:"GO:0042176"(regulation of protein catabolic process)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043405"(regulation of MAP kinase activity)|go:"GO:0044389"(ubiquitin-like protein ligase binding)|go:"GO:0046426"(negative regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0046872"(metal ion binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072657"(protein localization to membrane)|go:"GO:0097013"(phagocytic vesicle lumen)|go:"GO:1903543"(positive regulation of exosomal secretion)|interpro:IPR000306(Zinc finger, FYVE-type)|interpro:IPR002014(VHS)|interpro:IPR003903(Ubiquitin interacting motif)|interpro:IPR008942(ENTH/VHS)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017073(Ubiquitin binding protein, Hrs/VPS27)|interpro:IPR017455(Zinc finger, FYVE-related)|interpro:IPR024641|mint:O14964|rcsb pdb:2D3G|rcsb pdb:3F1I|rcsb pdb:3OBQ|rcsb pdb:3ZYQ|rcsb pdb:4AVX|reactome:R-HSA-182971|reactome:R-HSA-432720|reactome:R-HSA-5689880|reactome:R-HSA-6807004|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-8875360|reactome:R-HSA-9013420|reactome:R-HSA-917729|reactome:R-HSA-9635644|reactome:R-HSA-9636383|reactome:R-HSA-9706019	refseq:NP_003339.1|dip:DIP-29829N|ensembl:ENSG00000177889(gene)|ensembl:ENST00000318066(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000729"(DNA double-strand break processing)|go:"GO:0001650"(fibrillar center)|go:"GO:0003723"(RNA binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006282"(regulation of DNA repair)|go:"GO:0006301"(postreplication repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016574"(histone ubiquitination)|go:"GO:0031058"(positive regulation of histone modification)|go:"GO:0031372"(UBC13-MMS2 complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033182"(regulation of histone ubiquitination)|go:"GO:0035370"(UBC13-UEV1A complex)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0061631"(ubiquitin conjugating enzyme activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070534"(protein K63-linked ubiquitination)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|interpro:IPR023313|rcsb pdb:1J7D|rcsb pdb:2C2V|rcsb pdb:3HCT|rcsb pdb:3HCU|rcsb pdb:3VON|rcsb pdb:3W31|rcsb pdb:4DHI|rcsb pdb:4DHJ|rcsb pdb:4DHZ|rcsb pdb:4IP3|rcsb pdb:4NR3|rcsb pdb:4NRG|rcsb pdb:4NRI|rcsb pdb:4ONL|rcsb pdb:4ONM|rcsb pdb:4ONN|rcsb pdb:4ORH|rcsb pdb:4TKP|rcsb pdb:4WHV|rcsb pdb:5AIT|rcsb pdb:5AIU|rcsb pdb:5EYA|rcsb pdb:5H7S|rcsb pdb:5VNZ|rcsb pdb:5VO0|rcsb pdb:5YWR|rcsb pdb:6D6I|rcsb pdb:6JKY|rcsb pdb:6KFP|rcsb pdb:6KG6|rcsb pdb:6KL4|rcsb pdb:6LP2|rcsb pdb:6P5B|rcsb pdb:6S53|reactome:R-HSA-168927|reactome:R-HSA-202424|reactome:R-HSA-2871837|reactome:R-HSA-445989|reactome:R-HSA-450302|reactome:R-HSA-450321|reactome:R-HSA-5607764|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-5696395|reactome:R-HSA-69473|reactome:R-HSA-8866654|reactome:R-HSA-9020702|reactome:R-HSA-937039|reactome:R-HSA-937041|reactome:R-HSA-9646399|reactome:R-HSA-975110|reactome:R-HSA-975144|reactome:R-HSA-983168|rcsb pdb:6ULH|rcsb pdb:6UMP|rcsb pdb:6UMS|rcsb pdb:7BBD|rcsb pdb:7BBF|rcsb pdb:7BXG|reactome:R-HSA-1169408|reactome:R-HSA-168638	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S3|resulting-ptm:O14964 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:z/AnREuqEpyJ9/Zj6JFCJCJem1I9606	rogid:dqdszHlq5FLPHC6UWX6uvkC6Yz89606	intact-crc:FFDEF4AC7B05FE7D|rigid:hO/vS27pQET2bE16aMAT5TtSNRM	false	-	his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q62925	uniprotkb:O60784	intact:EBI-636664	intact:EBI-74634|intact:EBI-28971074|ensembl:ENSP00000394466|uniprotkb:Q5TIJ6|uniprotkb:B4DEL9|uniprotkb:B4DNA1|uniprotkb:Q86X74	psi-mi:m3k1_rat(display_long)|uniprotkb:MAPK/ERK kinase kinase 1(gene name synonym)|uniprotkb:Map3k1(gene name)|psi-mi:Map3k1(display_short)|uniprotkb:Mekk(gene name synonym)|uniprotkb:Mekk1(gene name synonym)	psi-mi:tom1_human(display_long)|uniprotkb:TOM1(gene name)|psi-mi:TOM1(display_short)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9971359|imex:IM-22822-68	author-confidence:Z-score = 10.77	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:620966|refseq:NP_446339.1|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR007527(Zinc finger, SWIM-type)|go:"GO:0000165"(MAPK cascade)|interpro:IPR016024(Armadillo-type fold)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0002011"(morphogenesis of an epithelial sheet)|go:"GO:0003382"(epithelial cell morphogenesis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004706"(JUN kinase kinase kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007254"(JNK cascade)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008432"(JUN kinase binding)|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0016020"(membrane)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0031434"(mitogen-activated protein kinase kinase binding)|go:"GO:0031941"(filamentous actin)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0042060"(wound healing)|go:"GO:0043010"(camera-type eye development)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046625"(sphingolipid binding)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050434"(positive regulation of viral transcription)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0061029"(eyelid development in camera-type eye)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|reactome:R-RNO-166058|reactome:R-RNO-2871796|reactome:R-RNO-975138|reactome:R-RNO-975871|interpro:IPR011989(Armadillo-like helical)|mint:Q62925	ensembl:ENSG00000100284(gene)|ensembl:ENST00000449058(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006897"(endocytosis)|go:"GO:0007165"(signal transduction)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0016197"(endosomal transport)|go:"GO:0030276"(clathrin binding)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0035579"(specific granule membrane)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR002014(VHS)|interpro:IPR004152(GAT)|interpro:IPR008942(ENTH/VHS)|interpro:IPR014645(Target of Myb protein 1)|interpro:IPR038425|mint:O60784|ensembl:ENST00000411850|ensembl:ENSP00000413697|ensembl:ENST00000425375|ensembl:ENSP00000394924|ensembl:ENST00000447733|ensembl:ENSP00000398876|ensembl:ENSP00000394466|refseq:NP_001129201.1|refseq:NP_001129202.1|refseq:NP_001129204.1|refseq:NP_005479.1|rcsb pdb:1ELK|rcsb pdb:1WRD|rcsb pdb:2N2N|rcsb pdb:2N9D|rcsb pdb:6J56|reactome:R-HSA-6798695|dip:DIP-30844N	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S3|resulting-ptm:O60784 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:EwhjYjowkZIAt4UyPcZBUtf9uak10116	rogid:MLXfzLA4x1/vwxwbzO5zowzkOtU9606	intact-crc:7C542A3033B2C758|rigid:t9XUTEHQGOP5hvEn4ibHSTmzQBQ	false	sufficient binding region:433-481(IPR013083)	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q62925	uniprotkb:Q13404	intact:EBI-636664	intact:EBI-1050671|uniprotkb:Q13403|uniprotkb:Q13532|uniprotkb:Q96H34|uniprotkb:Q9GZT0|uniprotkb:Q9GZW1|uniprotkb:Q9H4J3|uniprotkb:Q9H4J4|uniprotkb:Q9UKL1|uniprotkb:Q9UM48|uniprotkb:Q9UM49|uniprotkb:Q9UM50|uniprotkb:Q5TGE3|uniprotkb:E1P629|uniprotkb:Q5TGE0|ensembl:ENSP00000360739	psi-mi:m3k1_rat(display_long)|uniprotkb:MAPK/ERK kinase kinase 1(gene name synonym)|uniprotkb:Map3k1(gene name)|psi-mi:Map3k1(display_short)|uniprotkb:Mekk(gene name synonym)|uniprotkb:Mekk1(gene name synonym)	psi-mi:ub2v1_human(display_long)|uniprotkb:CROC-1(gene name synonym)|uniprotkb:TRAF6-regulated IKK activator 1 beta Uev1A(gene name synonym)|uniprotkb:P/OKcl.19(orf name)|uniprotkb:UBE2V1(gene name)|psi-mi:UBE2V1(display_short)|uniprotkb:CROC1(gene name synonym)|uniprotkb:UBE2V(gene name synonym)|uniprotkb:UEV1(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9971359|imex:IM-22822-68	author-confidence:Z-score = 10.77	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:620966|refseq:NP_446339.1|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR007527(Zinc finger, SWIM-type)|go:"GO:0000165"(MAPK cascade)|interpro:IPR016024(Armadillo-type fold)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0002011"(morphogenesis of an epithelial sheet)|go:"GO:0003382"(epithelial cell morphogenesis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004706"(JUN kinase kinase kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007254"(JNK cascade)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008432"(JUN kinase binding)|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0016020"(membrane)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0031434"(mitogen-activated protein kinase kinase binding)|go:"GO:0031941"(filamentous actin)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0042060"(wound healing)|go:"GO:0043010"(camera-type eye development)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046625"(sphingolipid binding)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050434"(positive regulation of viral transcription)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0061029"(eyelid development in camera-type eye)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|reactome:R-RNO-166058|reactome:R-RNO-2871796|reactome:R-RNO-975138|reactome:R-RNO-975871|interpro:IPR011989(Armadillo-like helical)|mint:Q62925	refseq:NP_001027459.1|refseq:NP_068823.2|refseq:NP_071887.1|refseq:NP_954595.1|refseq:NP_954673.1|refseq:NP_001244322.1|refseq:NP_001244323.1|refseq:NP_001244325.1|ensembl:ENSG00000244687(gene)|ensembl:ENST00000371674(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006282"(regulation of DNA repair)|go:"GO:0006301"(postreplication repair)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0030154"(cell differentiation)|go:"GO:0031371"(ubiquitin conjugating enzyme complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035370"(UBC13-UEV1A complex)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070534"(protein K63-linked ubiquitination)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|rcsb pdb:2A4D|rcsb pdb:2C2V|rcsb pdb:2HLW|rcsb pdb:6D6I|reactome:R-HSA-168638|reactome:R-HSA-168927|reactome:R-HSA-202424|reactome:R-HSA-2871837|reactome:R-HSA-445989|reactome:R-HSA-450302|reactome:R-HSA-450321|reactome:R-HSA-5607764|reactome:R-HSA-9020702|reactome:R-HSA-937039|reactome:R-HSA-937041|reactome:R-HSA-9646399|reactome:R-HSA-975110|reactome:R-HSA-975144|reactome:R-HSA-983168|dip:DIP-41911N	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S3|resulting-ptm:O60784 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:EwhjYjowkZIAt4UyPcZBUtf9uak10116	rogid:x95N7Dj2KIqu5gySX59xLmfthUg9606	intact-crc:7C542A3033B2C758|rigid:t9XUTEHQGOP5hvEn4ibHSTmzQBQ	false	sufficient binding region:433-481(IPR013083)	his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q62925	uniprotkb:P22314	intact:EBI-636664	intact:EBI-709688|uniprotkb:Q96E13|uniprotkb:Q5JRR8|ensembl:ENSP00000338413|ensembl:ENSP00000366568	psi-mi:m3k1_rat(display_long)|uniprotkb:MAPK/ERK kinase kinase 1(gene name synonym)|uniprotkb:Map3k1(gene name)|psi-mi:Map3k1(display_short)|uniprotkb:Mekk(gene name synonym)|uniprotkb:Mekk1(gene name synonym)	psi-mi:uba1_human(display_long)|uniprotkb:Ubiquitin-activating enzyme E1(gene name synonym)|uniprotkb:Protein A1S9(gene name synonym)|uniprotkb:UBA1(gene name)|psi-mi:UBA1(display_short)|uniprotkb:A1S9T(gene name synonym)|uniprotkb:UBE1(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9971359|imex:IM-22822-68	author-confidence:Z-score = 10.77	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:620966|refseq:NP_446339.1|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR007527(Zinc finger, SWIM-type)|go:"GO:0000165"(MAPK cascade)|interpro:IPR016024(Armadillo-type fold)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0002011"(morphogenesis of an epithelial sheet)|go:"GO:0003382"(epithelial cell morphogenesis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004706"(JUN kinase kinase kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007254"(JNK cascade)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008432"(JUN kinase binding)|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0016020"(membrane)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0031434"(mitogen-activated protein kinase kinase binding)|go:"GO:0031941"(filamentous actin)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0042060"(wound healing)|go:"GO:0043010"(camera-type eye development)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046625"(sphingolipid binding)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050434"(positive regulation of viral transcription)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0061029"(eyelid development in camera-type eye)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|reactome:R-RNO-166058|reactome:R-RNO-2871796|reactome:R-RNO-975138|reactome:R-RNO-975871|interpro:IPR011989(Armadillo-like helical)|mint:Q62925	refseq:NP_003325.2|refseq:NP_695012.1|refseq:XP_016885269.1|refseq:XP_016885270.1|dip:DIP-33686N|ensembl:ENSG00000130985(gene)|ensembl:ENST00000335972(transcript)|ensembl:ENST00000377351(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0004839"(ubiquitin activating enzyme activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0032446"(protein modification by small protein conjugation)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000011(Ubiquitin-activating enzyme, E1)|interpro:IPR000594(UBA/THIF-type NAD/FAD binding fold)|interpro:IPR018074|interpro:IPR018075|interpro:IPR018965|interpro:IPR019572|interpro:IPR032418|interpro:IPR032420|interpro:IPR033127|interpro:IPR035985|interpro:IPR038252|interpro:IPR042063|interpro:IPR042302|interpro:IPR042449|mint:P22314|rcsb pdb:4P22|rcsb pdb:6DC6|reactome:R-HSA-8866652|reactome:R-HSA-983168	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S3|resulting-ptm:O60784 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:EwhjYjowkZIAt4UyPcZBUtf9uak10116	rogid:q+vEeA0XLST0Zz173bmEt0dNbDE9606	intact-crc:7C542A3033B2C758|rigid:t9XUTEHQGOP5hvEn4ibHSTmzQBQ	false	sufficient binding region:433-481(IPR013083)	his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q62925	uniprotkb:P61088	intact:EBI-636664	intact:EBI-1052908|uniprotkb:Q16781|uniprotkb:Q53Y81|ensembl:ENSP00000316176	psi-mi:m3k1_rat(display_long)|uniprotkb:MAPK/ERK kinase kinase 1(gene name synonym)|uniprotkb:Map3k1(gene name)|psi-mi:Map3k1(display_short)|uniprotkb:Mekk(gene name synonym)|uniprotkb:Mekk1(gene name synonym)	psi-mi:ube2n_human(display_long)|uniprotkb:Ubiquitin-protein ligase N(gene name synonym)|uniprotkb:Ubiquitin carrier protein N(gene name synonym)|uniprotkb:Ubc13(gene name synonym)|uniprotkb:Bendless-like ubiquitin-conjugating enzyme(gene name synonym)|uniprotkb:UBE2N(gene name)|psi-mi:UBE2N(display_short)|uniprotkb:BLU(gene name synonym)|uniprotkb:UbcH13(gene name synonym)|uniprotkb:E2 ubiquitin-conjugating enzyme N(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9971359|imex:IM-22822-68	author-confidence:Z-score = 10.77	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:620966|refseq:NP_446339.1|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR007527(Zinc finger, SWIM-type)|go:"GO:0000165"(MAPK cascade)|interpro:IPR016024(Armadillo-type fold)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0002011"(morphogenesis of an epithelial sheet)|go:"GO:0003382"(epithelial cell morphogenesis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004706"(JUN kinase kinase kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007254"(JNK cascade)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008432"(JUN kinase binding)|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0016020"(membrane)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0031434"(mitogen-activated protein kinase kinase binding)|go:"GO:0031941"(filamentous actin)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0042060"(wound healing)|go:"GO:0043010"(camera-type eye development)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046625"(sphingolipid binding)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050434"(positive regulation of viral transcription)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0061029"(eyelid development in camera-type eye)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|reactome:R-RNO-166058|reactome:R-RNO-2871796|reactome:R-RNO-975138|reactome:R-RNO-975871|interpro:IPR011989(Armadillo-like helical)|mint:Q62925	refseq:NP_003339.1|dip:DIP-29829N|ensembl:ENSG00000177889(gene)|ensembl:ENST00000318066(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000729"(DNA double-strand break processing)|go:"GO:0001650"(fibrillar center)|go:"GO:0003723"(RNA binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006282"(regulation of DNA repair)|go:"GO:0006301"(postreplication repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016574"(histone ubiquitination)|go:"GO:0031058"(positive regulation of histone modification)|go:"GO:0031372"(UBC13-MMS2 complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033182"(regulation of histone ubiquitination)|go:"GO:0035370"(UBC13-UEV1A complex)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0061631"(ubiquitin conjugating enzyme activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070534"(protein K63-linked ubiquitination)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|interpro:IPR023313|rcsb pdb:1J7D|rcsb pdb:2C2V|rcsb pdb:3HCT|rcsb pdb:3HCU|rcsb pdb:3VON|rcsb pdb:3W31|rcsb pdb:4DHI|rcsb pdb:4DHJ|rcsb pdb:4DHZ|rcsb pdb:4IP3|rcsb pdb:4NR3|rcsb pdb:4NRG|rcsb pdb:4NRI|rcsb pdb:4ONL|rcsb pdb:4ONM|rcsb pdb:4ONN|rcsb pdb:4ORH|rcsb pdb:4TKP|rcsb pdb:4WHV|rcsb pdb:5AIT|rcsb pdb:5AIU|rcsb pdb:5EYA|rcsb pdb:5H7S|rcsb pdb:5VNZ|rcsb pdb:5VO0|rcsb pdb:5YWR|rcsb pdb:6D6I|rcsb pdb:6JKY|rcsb pdb:6KFP|rcsb pdb:6KG6|rcsb pdb:6KL4|rcsb pdb:6LP2|rcsb pdb:6P5B|rcsb pdb:6S53|reactome:R-HSA-168927|reactome:R-HSA-202424|reactome:R-HSA-2871837|reactome:R-HSA-445989|reactome:R-HSA-450302|reactome:R-HSA-450321|reactome:R-HSA-5607764|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-5696395|reactome:R-HSA-69473|reactome:R-HSA-8866654|reactome:R-HSA-9020702|reactome:R-HSA-937039|reactome:R-HSA-937041|reactome:R-HSA-9646399|reactome:R-HSA-975110|reactome:R-HSA-975144|reactome:R-HSA-983168|rcsb pdb:6ULH|rcsb pdb:6UMP|rcsb pdb:6UMS|rcsb pdb:7BBD|rcsb pdb:7BBF|rcsb pdb:7BXG|reactome:R-HSA-1169408|reactome:R-HSA-168638	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S3|resulting-ptm:O60784 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:EwhjYjowkZIAt4UyPcZBUtf9uak10116	rogid:dqdszHlq5FLPHC6UWX6uvkC6Yz89606	intact-crc:7C542A3033B2C758|rigid:t9XUTEHQGOP5hvEn4ibHSTmzQBQ	false	sufficient binding region:433-481(IPR013083)	his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O75190	uniprotkb:Q62925	intact:EBI-1053164|uniprotkb:A4D232|uniprotkb:O95806|uniprotkb:A8KAG0|uniprotkb:B4DN73|uniprotkb:E9PCZ2|uniprotkb:Q53EN8|uniprotkb:Q59EF2|uniprotkb:Q6FIC8|uniprotkb:Q75MA2|uniprotkb:Q9UIK6|uniprotkb:A8K7D8|ensembl:ENSP00000262177	intact:EBI-636664	psi-mi:dnjb6_human(display_long)|uniprotkb:Heat shock protein J2(gene name synonym)|uniprotkb:MSJ-1(gene name synonym)|uniprotkb:HHDJ1(gene name synonym)|uniprotkb:DNAJB6(gene name)|psi-mi:DNAJB6(display_short)|uniprotkb:HSJ2(gene name synonym)|uniprotkb:MSJ1(gene name synonym)|uniprotkb:MRJ(gene name synonym)	psi-mi:m3k1_rat(display_long)|uniprotkb:MAPK/ERK kinase kinase 1(gene name synonym)|uniprotkb:Map3k1(gene name)|psi-mi:Map3k1(display_short)|uniprotkb:Mekk(gene name synonym)|uniprotkb:Mekk1(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9971410|imex:IM-22822-70	author-confidence:Z-score = 10.77	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005485.1|refseq:NP_490647.1|ensembl:ENSG00000105993(gene)|ensembl:ENST00000262177(transcript)|go:"GO:0001671"(ATPase activator activity)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0045109"(intermediate filament organization)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0060710"(chorio-allantoic fusion)|go:"GO:0060715"(syncytiotrophoblast cell differentiation involved in labyrinthine layer development)|go:"GO:0060717"(chorion development)|go:"GO:0090084"(negative regulation of inclusion body assembly)|go:"GO:1900034"(regulation of cellular response to heat)|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR018253|interpro:IPR036869|mint:O75190|rcsb pdb:6U3R|rcsb pdb:6U3S|rcsb pdb:7JSQ|reactome:R-HSA-3371453|go:"GO:0016020"(membrane)|go:"GO:0030018"(Z disc)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0042802"(identical protein binding)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)	rgd:620966|refseq:NP_446339.1|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR007527(Zinc finger, SWIM-type)|go:"GO:0000165"(MAPK cascade)|interpro:IPR016024(Armadillo-type fold)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0002011"(morphogenesis of an epithelial sheet)|go:"GO:0003382"(epithelial cell morphogenesis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004706"(JUN kinase kinase kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007254"(JNK cascade)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008432"(JUN kinase binding)|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0016020"(membrane)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0031434"(mitogen-activated protein kinase kinase binding)|go:"GO:0031941"(filamentous actin)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0042060"(wound healing)|go:"GO:0043010"(camera-type eye development)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046625"(sphingolipid binding)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050434"(positive regulation of viral transcription)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0061029"(eyelid development in camera-type eye)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|reactome:R-RNO-166058|reactome:R-RNO-2871796|reactome:R-RNO-975138|reactome:R-RNO-975871|interpro:IPR011989(Armadillo-like helical)|mint:Q62925	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S3|resulting-ptm:O75190 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:6X99Uu2SBlHsGCv61ZbwSz4LRp89606	rogid:EwhjYjowkZIAt4UyPcZBUtf9uak10116	intact-crc:05F74660092620C2|rigid:Pq1RiIdfHYJxEi4fu4I26FzfhUs	false	-	sufficient binding region:433-481(IPR013083)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O75190	uniprotkb:Q13404	intact:EBI-1053164|uniprotkb:A4D232|uniprotkb:O95806|uniprotkb:A8KAG0|uniprotkb:B4DN73|uniprotkb:E9PCZ2|uniprotkb:Q53EN8|uniprotkb:Q59EF2|uniprotkb:Q6FIC8|uniprotkb:Q75MA2|uniprotkb:Q9UIK6|uniprotkb:A8K7D8|ensembl:ENSP00000262177	intact:EBI-1050671|uniprotkb:Q13403|uniprotkb:Q13532|uniprotkb:Q96H34|uniprotkb:Q9GZT0|uniprotkb:Q9GZW1|uniprotkb:Q9H4J3|uniprotkb:Q9H4J4|uniprotkb:Q9UKL1|uniprotkb:Q9UM48|uniprotkb:Q9UM49|uniprotkb:Q9UM50|uniprotkb:Q5TGE3|uniprotkb:E1P629|uniprotkb:Q5TGE0|ensembl:ENSP00000360739	psi-mi:dnjb6_human(display_long)|uniprotkb:Heat shock protein J2(gene name synonym)|uniprotkb:MSJ-1(gene name synonym)|uniprotkb:HHDJ1(gene name synonym)|uniprotkb:DNAJB6(gene name)|psi-mi:DNAJB6(display_short)|uniprotkb:HSJ2(gene name synonym)|uniprotkb:MSJ1(gene name synonym)|uniprotkb:MRJ(gene name synonym)	psi-mi:ub2v1_human(display_long)|uniprotkb:CROC-1(gene name synonym)|uniprotkb:TRAF6-regulated IKK activator 1 beta Uev1A(gene name synonym)|uniprotkb:P/OKcl.19(orf name)|uniprotkb:UBE2V1(gene name)|psi-mi:UBE2V1(display_short)|uniprotkb:CROC1(gene name synonym)|uniprotkb:UBE2V(gene name synonym)|uniprotkb:UEV1(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9971410|imex:IM-22822-70	author-confidence:Z-score = 10.77	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005485.1|refseq:NP_490647.1|ensembl:ENSG00000105993(gene)|ensembl:ENST00000262177(transcript)|go:"GO:0001671"(ATPase activator activity)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0045109"(intermediate filament organization)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0060710"(chorio-allantoic fusion)|go:"GO:0060715"(syncytiotrophoblast cell differentiation involved in labyrinthine layer development)|go:"GO:0060717"(chorion development)|go:"GO:0090084"(negative regulation of inclusion body assembly)|go:"GO:1900034"(regulation of cellular response to heat)|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR018253|interpro:IPR036869|mint:O75190|rcsb pdb:6U3R|rcsb pdb:6U3S|rcsb pdb:7JSQ|reactome:R-HSA-3371453|go:"GO:0016020"(membrane)|go:"GO:0030018"(Z disc)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0042802"(identical protein binding)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)	refseq:NP_001027459.1|refseq:NP_068823.2|refseq:NP_071887.1|refseq:NP_954595.1|refseq:NP_954673.1|refseq:NP_001244322.1|refseq:NP_001244323.1|refseq:NP_001244325.1|ensembl:ENSG00000244687(gene)|ensembl:ENST00000371674(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006282"(regulation of DNA repair)|go:"GO:0006301"(postreplication repair)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0030154"(cell differentiation)|go:"GO:0031371"(ubiquitin conjugating enzyme complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035370"(UBC13-UEV1A complex)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070534"(protein K63-linked ubiquitination)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|rcsb pdb:2A4D|rcsb pdb:2C2V|rcsb pdb:2HLW|rcsb pdb:6D6I|reactome:R-HSA-168638|reactome:R-HSA-168927|reactome:R-HSA-202424|reactome:R-HSA-2871837|reactome:R-HSA-445989|reactome:R-HSA-450302|reactome:R-HSA-450321|reactome:R-HSA-5607764|reactome:R-HSA-9020702|reactome:R-HSA-937039|reactome:R-HSA-937041|reactome:R-HSA-9646399|reactome:R-HSA-975110|reactome:R-HSA-975144|reactome:R-HSA-983168|dip:DIP-41911N	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S3|resulting-ptm:O75190 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:6X99Uu2SBlHsGCv61ZbwSz4LRp89606	rogid:x95N7Dj2KIqu5gySX59xLmfthUg9606	intact-crc:05F74660092620C2|rigid:Pq1RiIdfHYJxEi4fu4I26FzfhUs	false	-	his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O75190	uniprotkb:P22314	intact:EBI-1053164|uniprotkb:A4D232|uniprotkb:O95806|uniprotkb:A8KAG0|uniprotkb:B4DN73|uniprotkb:E9PCZ2|uniprotkb:Q53EN8|uniprotkb:Q59EF2|uniprotkb:Q6FIC8|uniprotkb:Q75MA2|uniprotkb:Q9UIK6|uniprotkb:A8K7D8|ensembl:ENSP00000262177	intact:EBI-709688|uniprotkb:Q96E13|uniprotkb:Q5JRR8|ensembl:ENSP00000338413|ensembl:ENSP00000366568	psi-mi:dnjb6_human(display_long)|uniprotkb:Heat shock protein J2(gene name synonym)|uniprotkb:MSJ-1(gene name synonym)|uniprotkb:HHDJ1(gene name synonym)|uniprotkb:DNAJB6(gene name)|psi-mi:DNAJB6(display_short)|uniprotkb:HSJ2(gene name synonym)|uniprotkb:MSJ1(gene name synonym)|uniprotkb:MRJ(gene name synonym)	psi-mi:uba1_human(display_long)|uniprotkb:Ubiquitin-activating enzyme E1(gene name synonym)|uniprotkb:Protein A1S9(gene name synonym)|uniprotkb:UBA1(gene name)|psi-mi:UBA1(display_short)|uniprotkb:A1S9T(gene name synonym)|uniprotkb:UBE1(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9971410|imex:IM-22822-70	author-confidence:Z-score = 10.77	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005485.1|refseq:NP_490647.1|ensembl:ENSG00000105993(gene)|ensembl:ENST00000262177(transcript)|go:"GO:0001671"(ATPase activator activity)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0045109"(intermediate filament organization)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0060710"(chorio-allantoic fusion)|go:"GO:0060715"(syncytiotrophoblast cell differentiation involved in labyrinthine layer development)|go:"GO:0060717"(chorion development)|go:"GO:0090084"(negative regulation of inclusion body assembly)|go:"GO:1900034"(regulation of cellular response to heat)|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR018253|interpro:IPR036869|mint:O75190|rcsb pdb:6U3R|rcsb pdb:6U3S|rcsb pdb:7JSQ|reactome:R-HSA-3371453|go:"GO:0016020"(membrane)|go:"GO:0030018"(Z disc)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0042802"(identical protein binding)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)	refseq:NP_003325.2|refseq:NP_695012.1|refseq:XP_016885269.1|refseq:XP_016885270.1|dip:DIP-33686N|ensembl:ENSG00000130985(gene)|ensembl:ENST00000335972(transcript)|ensembl:ENST00000377351(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0004839"(ubiquitin activating enzyme activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0032446"(protein modification by small protein conjugation)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000011(Ubiquitin-activating enzyme, E1)|interpro:IPR000594(UBA/THIF-type NAD/FAD binding fold)|interpro:IPR018074|interpro:IPR018075|interpro:IPR018965|interpro:IPR019572|interpro:IPR032418|interpro:IPR032420|interpro:IPR033127|interpro:IPR035985|interpro:IPR038252|interpro:IPR042063|interpro:IPR042302|interpro:IPR042449|mint:P22314|rcsb pdb:4P22|rcsb pdb:6DC6|reactome:R-HSA-8866652|reactome:R-HSA-983168	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S3|resulting-ptm:O75190 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:6X99Uu2SBlHsGCv61ZbwSz4LRp89606	rogid:q+vEeA0XLST0Zz173bmEt0dNbDE9606	intact-crc:05F74660092620C2|rigid:Pq1RiIdfHYJxEi4fu4I26FzfhUs	false	-	his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O75190	uniprotkb:P61088	intact:EBI-1053164|uniprotkb:A4D232|uniprotkb:O95806|uniprotkb:A8KAG0|uniprotkb:B4DN73|uniprotkb:E9PCZ2|uniprotkb:Q53EN8|uniprotkb:Q59EF2|uniprotkb:Q6FIC8|uniprotkb:Q75MA2|uniprotkb:Q9UIK6|uniprotkb:A8K7D8|ensembl:ENSP00000262177	intact:EBI-1052908|uniprotkb:Q16781|uniprotkb:Q53Y81|ensembl:ENSP00000316176	psi-mi:dnjb6_human(display_long)|uniprotkb:Heat shock protein J2(gene name synonym)|uniprotkb:MSJ-1(gene name synonym)|uniprotkb:HHDJ1(gene name synonym)|uniprotkb:DNAJB6(gene name)|psi-mi:DNAJB6(display_short)|uniprotkb:HSJ2(gene name synonym)|uniprotkb:MSJ1(gene name synonym)|uniprotkb:MRJ(gene name synonym)	psi-mi:ube2n_human(display_long)|uniprotkb:Ubiquitin-protein ligase N(gene name synonym)|uniprotkb:Ubiquitin carrier protein N(gene name synonym)|uniprotkb:Ubc13(gene name synonym)|uniprotkb:Bendless-like ubiquitin-conjugating enzyme(gene name synonym)|uniprotkb:UBE2N(gene name)|psi-mi:UBE2N(display_short)|uniprotkb:BLU(gene name synonym)|uniprotkb:UbcH13(gene name synonym)|uniprotkb:E2 ubiquitin-conjugating enzyme N(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9971410|imex:IM-22822-70	author-confidence:Z-score = 10.77	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005485.1|refseq:NP_490647.1|ensembl:ENSG00000105993(gene)|ensembl:ENST00000262177(transcript)|go:"GO:0001671"(ATPase activator activity)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0045109"(intermediate filament organization)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0060710"(chorio-allantoic fusion)|go:"GO:0060715"(syncytiotrophoblast cell differentiation involved in labyrinthine layer development)|go:"GO:0060717"(chorion development)|go:"GO:0090084"(negative regulation of inclusion body assembly)|go:"GO:1900034"(regulation of cellular response to heat)|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR018253|interpro:IPR036869|mint:O75190|rcsb pdb:6U3R|rcsb pdb:6U3S|rcsb pdb:7JSQ|reactome:R-HSA-3371453|go:"GO:0016020"(membrane)|go:"GO:0030018"(Z disc)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0042802"(identical protein binding)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)	refseq:NP_003339.1|dip:DIP-29829N|ensembl:ENSG00000177889(gene)|ensembl:ENST00000318066(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000729"(DNA double-strand break processing)|go:"GO:0001650"(fibrillar center)|go:"GO:0003723"(RNA binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006282"(regulation of DNA repair)|go:"GO:0006301"(postreplication repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016574"(histone ubiquitination)|go:"GO:0031058"(positive regulation of histone modification)|go:"GO:0031372"(UBC13-MMS2 complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033182"(regulation of histone ubiquitination)|go:"GO:0035370"(UBC13-UEV1A complex)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0061631"(ubiquitin conjugating enzyme activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070534"(protein K63-linked ubiquitination)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|interpro:IPR023313|rcsb pdb:1J7D|rcsb pdb:2C2V|rcsb pdb:3HCT|rcsb pdb:3HCU|rcsb pdb:3VON|rcsb pdb:3W31|rcsb pdb:4DHI|rcsb pdb:4DHJ|rcsb pdb:4DHZ|rcsb pdb:4IP3|rcsb pdb:4NR3|rcsb pdb:4NRG|rcsb pdb:4NRI|rcsb pdb:4ONL|rcsb pdb:4ONM|rcsb pdb:4ONN|rcsb pdb:4ORH|rcsb pdb:4TKP|rcsb pdb:4WHV|rcsb pdb:5AIT|rcsb pdb:5AIU|rcsb pdb:5EYA|rcsb pdb:5H7S|rcsb pdb:5VNZ|rcsb pdb:5VO0|rcsb pdb:5YWR|rcsb pdb:6D6I|rcsb pdb:6JKY|rcsb pdb:6KFP|rcsb pdb:6KG6|rcsb pdb:6KL4|rcsb pdb:6LP2|rcsb pdb:6P5B|rcsb pdb:6S53|reactome:R-HSA-168927|reactome:R-HSA-202424|reactome:R-HSA-2871837|reactome:R-HSA-445989|reactome:R-HSA-450302|reactome:R-HSA-450321|reactome:R-HSA-5607764|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-5696395|reactome:R-HSA-69473|reactome:R-HSA-8866654|reactome:R-HSA-9020702|reactome:R-HSA-937039|reactome:R-HSA-937041|reactome:R-HSA-9646399|reactome:R-HSA-975110|reactome:R-HSA-975144|reactome:R-HSA-983168|rcsb pdb:6ULH|rcsb pdb:6UMP|rcsb pdb:6UMS|rcsb pdb:7BBD|rcsb pdb:7BBF|rcsb pdb:7BXG|reactome:R-HSA-1169408|reactome:R-HSA-168638	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S3|resulting-ptm:O75190 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:6X99Uu2SBlHsGCv61ZbwSz4LRp89606	rogid:dqdszHlq5FLPHC6UWX6uvkC6Yz89606	intact-crc:05F74660092620C2|rigid:Pq1RiIdfHYJxEi4fu4I26FzfhUs	false	-	his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O75146	uniprotkb:Q62925	intact:EBI-4402639|uniprotkb:A6NHQ6|uniprotkb:Q9UED9|uniprotkb:Q6NXG8|ensembl:ENSP00000253083	intact:EBI-636664	psi-mi:hip1r_human(display_long)|uniprotkb:HIP1R(gene name)|psi-mi:HIP1R(display_short)|uniprotkb:HIP12(gene name synonym)|uniprotkb:KIAA0655(gene name synonym)|uniprotkb:Huntingtin-interacting protein 12(gene name synonym)	psi-mi:m3k1_rat(display_long)|uniprotkb:MAPK/ERK kinase kinase 1(gene name synonym)|uniprotkb:Map3k1(gene name)|psi-mi:Map3k1(display_short)|uniprotkb:Mekk(gene name synonym)|uniprotkb:Mekk1(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9971384|imex:IM-22822-69	author-confidence:Z-score = 7.84|author-confidence:Z-score = 7.92	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_003950.1|refseq:NP_001290026.1|dip:DIP-17042N|ensembl:ENST00000253083(transcript)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005547"(phosphatidylinositol-3,4,5-trisphosphate binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0005938"(cell cortex)|go:"GO:0006897"(endocytosis)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007015"(actin filament organization)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0030100"(regulation of endocytosis)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030276"(clathrin binding)|ensembl:ENSG00000130787(gene)|go:"GO:0030837"(negative regulation of actin filament polymerization)|go:"GO:0032051"(clathrin light chain binding)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0034316"(negative regulation of Arp2/3 complex-mediated actin nucleation)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0035615"(clathrin adaptor activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043197"(dendritic spine)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043325"(phosphatidylinositol-3,4-bisphosphate binding)|go:"GO:0045742"(positive regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048268"(clathrin coat assembly)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050821"(protein stabilization)|go:"GO:0051015"(actin filament binding)|go:"GO:0055123"(digestive system development)|go:"GO:0060453"(regulation of gastric acid secretion)|go:"GO:0080025"(phosphatidylinositol-3,5-bisphosphate binding)|go:"GO:0097060"(synaptic membrane)|go:"GO:1901030"(positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway)|go:"GO:1905445"(positive regulation of clathrin coat assembly)|go:"GO:2000369"(regulation of clathrin-dependent endocytosis)|go:"GO:2000588"(positive regulation of platelet-derived growth factor receptor-beta signaling pathway)|interpro:IPR002558(I/LWEQ)|interpro:IPR008942(ENTH/VHS)|interpro:IPR011417(ANTH)|interpro:IPR013809(Epsin-like, N-terminal)|interpro:IPR030224|interpro:IPR030555|interpro:IPR032422|interpro:IPR035964|rcsb pdb:1R0D|reactome:R-HSA-432722|reactome:R-HSA-8856828|go:"GO:0030665"(clathrin-coated vesicle membrane)	rgd:620966|refseq:NP_446339.1|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR007527(Zinc finger, SWIM-type)|go:"GO:0000165"(MAPK cascade)|interpro:IPR016024(Armadillo-type fold)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0002011"(morphogenesis of an epithelial sheet)|go:"GO:0003382"(epithelial cell morphogenesis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004706"(JUN kinase kinase kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007254"(JNK cascade)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008432"(JUN kinase binding)|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0016020"(membrane)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0031434"(mitogen-activated protein kinase kinase binding)|go:"GO:0031941"(filamentous actin)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0042060"(wound healing)|go:"GO:0043010"(camera-type eye development)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046625"(sphingolipid binding)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050434"(positive regulation of viral transcription)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0061029"(eyelid development in camera-type eye)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|reactome:R-RNO-166058|reactome:R-RNO-2871796|reactome:R-RNO-975138|reactome:R-RNO-975871|interpro:IPR011989(Armadillo-like helical)|mint:Q62925	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S3|resulting-ptm:O75146 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:CnPCKHH1VcVfplrU2eR8WQ/+dho9606	rogid:EwhjYjowkZIAt4UyPcZBUtf9uak10116	intact-crc:B73940293CAD3BE6|rigid:Qwne4MW6aQXLnbq/loX7OqDxlFg	false	-	sufficient binding region:433-481(IPR013083)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O75146	uniprotkb:Q13404	intact:EBI-4402639|uniprotkb:A6NHQ6|uniprotkb:Q9UED9|uniprotkb:Q6NXG8|ensembl:ENSP00000253083	intact:EBI-1050671|uniprotkb:Q13403|uniprotkb:Q13532|uniprotkb:Q96H34|uniprotkb:Q9GZT0|uniprotkb:Q9GZW1|uniprotkb:Q9H4J3|uniprotkb:Q9H4J4|uniprotkb:Q9UKL1|uniprotkb:Q9UM48|uniprotkb:Q9UM49|uniprotkb:Q9UM50|uniprotkb:Q5TGE3|uniprotkb:E1P629|uniprotkb:Q5TGE0|ensembl:ENSP00000360739	psi-mi:hip1r_human(display_long)|uniprotkb:HIP1R(gene name)|psi-mi:HIP1R(display_short)|uniprotkb:HIP12(gene name synonym)|uniprotkb:KIAA0655(gene name synonym)|uniprotkb:Huntingtin-interacting protein 12(gene name synonym)	psi-mi:ub2v1_human(display_long)|uniprotkb:CROC-1(gene name synonym)|uniprotkb:TRAF6-regulated IKK activator 1 beta Uev1A(gene name synonym)|uniprotkb:P/OKcl.19(orf name)|uniprotkb:UBE2V1(gene name)|psi-mi:UBE2V1(display_short)|uniprotkb:CROC1(gene name synonym)|uniprotkb:UBE2V(gene name synonym)|uniprotkb:UEV1(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9971384|imex:IM-22822-69	author-confidence:Z-score = 7.84|author-confidence:Z-score = 7.92	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_003950.1|refseq:NP_001290026.1|dip:DIP-17042N|ensembl:ENST00000253083(transcript)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005547"(phosphatidylinositol-3,4,5-trisphosphate binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0005938"(cell cortex)|go:"GO:0006897"(endocytosis)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007015"(actin filament organization)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0030100"(regulation of endocytosis)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030276"(clathrin binding)|ensembl:ENSG00000130787(gene)|go:"GO:0030837"(negative regulation of actin filament polymerization)|go:"GO:0032051"(clathrin light chain binding)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0034316"(negative regulation of Arp2/3 complex-mediated actin nucleation)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0035615"(clathrin adaptor activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043197"(dendritic spine)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043325"(phosphatidylinositol-3,4-bisphosphate binding)|go:"GO:0045742"(positive regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048268"(clathrin coat assembly)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050821"(protein stabilization)|go:"GO:0051015"(actin filament binding)|go:"GO:0055123"(digestive system development)|go:"GO:0060453"(regulation of gastric acid secretion)|go:"GO:0080025"(phosphatidylinositol-3,5-bisphosphate binding)|go:"GO:0097060"(synaptic membrane)|go:"GO:1901030"(positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway)|go:"GO:1905445"(positive regulation of clathrin coat assembly)|go:"GO:2000369"(regulation of clathrin-dependent endocytosis)|go:"GO:2000588"(positive regulation of platelet-derived growth factor receptor-beta signaling pathway)|interpro:IPR002558(I/LWEQ)|interpro:IPR008942(ENTH/VHS)|interpro:IPR011417(ANTH)|interpro:IPR013809(Epsin-like, N-terminal)|interpro:IPR030224|interpro:IPR030555|interpro:IPR032422|interpro:IPR035964|rcsb pdb:1R0D|reactome:R-HSA-432722|reactome:R-HSA-8856828|go:"GO:0030665"(clathrin-coated vesicle membrane)	refseq:NP_001027459.1|refseq:NP_068823.2|refseq:NP_071887.1|refseq:NP_954595.1|refseq:NP_954673.1|refseq:NP_001244322.1|refseq:NP_001244323.1|refseq:NP_001244325.1|ensembl:ENSG00000244687(gene)|ensembl:ENST00000371674(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006282"(regulation of DNA repair)|go:"GO:0006301"(postreplication repair)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0030154"(cell differentiation)|go:"GO:0031371"(ubiquitin conjugating enzyme complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035370"(UBC13-UEV1A complex)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070534"(protein K63-linked ubiquitination)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|rcsb pdb:2A4D|rcsb pdb:2C2V|rcsb pdb:2HLW|rcsb pdb:6D6I|reactome:R-HSA-168638|reactome:R-HSA-168927|reactome:R-HSA-202424|reactome:R-HSA-2871837|reactome:R-HSA-445989|reactome:R-HSA-450302|reactome:R-HSA-450321|reactome:R-HSA-5607764|reactome:R-HSA-9020702|reactome:R-HSA-937039|reactome:R-HSA-937041|reactome:R-HSA-9646399|reactome:R-HSA-975110|reactome:R-HSA-975144|reactome:R-HSA-983168|dip:DIP-41911N	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S3|resulting-ptm:O75146 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:CnPCKHH1VcVfplrU2eR8WQ/+dho9606	rogid:x95N7Dj2KIqu5gySX59xLmfthUg9606	intact-crc:B73940293CAD3BE6|rigid:Qwne4MW6aQXLnbq/loX7OqDxlFg	false	-	his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O75146	uniprotkb:P22314	intact:EBI-4402639|uniprotkb:A6NHQ6|uniprotkb:Q9UED9|uniprotkb:Q6NXG8|ensembl:ENSP00000253083	intact:EBI-709688|uniprotkb:Q96E13|uniprotkb:Q5JRR8|ensembl:ENSP00000338413|ensembl:ENSP00000366568	psi-mi:hip1r_human(display_long)|uniprotkb:HIP1R(gene name)|psi-mi:HIP1R(display_short)|uniprotkb:HIP12(gene name synonym)|uniprotkb:KIAA0655(gene name synonym)|uniprotkb:Huntingtin-interacting protein 12(gene name synonym)	psi-mi:uba1_human(display_long)|uniprotkb:Ubiquitin-activating enzyme E1(gene name synonym)|uniprotkb:Protein A1S9(gene name synonym)|uniprotkb:UBA1(gene name)|psi-mi:UBA1(display_short)|uniprotkb:A1S9T(gene name synonym)|uniprotkb:UBE1(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9971384|imex:IM-22822-69	author-confidence:Z-score = 7.84|author-confidence:Z-score = 7.92	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_003950.1|refseq:NP_001290026.1|dip:DIP-17042N|ensembl:ENST00000253083(transcript)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005547"(phosphatidylinositol-3,4,5-trisphosphate binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0005938"(cell cortex)|go:"GO:0006897"(endocytosis)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007015"(actin filament organization)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0030100"(regulation of endocytosis)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030276"(clathrin binding)|ensembl:ENSG00000130787(gene)|go:"GO:0030837"(negative regulation of actin filament polymerization)|go:"GO:0032051"(clathrin light chain binding)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0034316"(negative regulation of Arp2/3 complex-mediated actin nucleation)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0035615"(clathrin adaptor activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043197"(dendritic spine)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043325"(phosphatidylinositol-3,4-bisphosphate binding)|go:"GO:0045742"(positive regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048268"(clathrin coat assembly)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050821"(protein stabilization)|go:"GO:0051015"(actin filament binding)|go:"GO:0055123"(digestive system development)|go:"GO:0060453"(regulation of gastric acid secretion)|go:"GO:0080025"(phosphatidylinositol-3,5-bisphosphate binding)|go:"GO:0097060"(synaptic membrane)|go:"GO:1901030"(positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway)|go:"GO:1905445"(positive regulation of clathrin coat assembly)|go:"GO:2000369"(regulation of clathrin-dependent endocytosis)|go:"GO:2000588"(positive regulation of platelet-derived growth factor receptor-beta signaling pathway)|interpro:IPR002558(I/LWEQ)|interpro:IPR008942(ENTH/VHS)|interpro:IPR011417(ANTH)|interpro:IPR013809(Epsin-like, N-terminal)|interpro:IPR030224|interpro:IPR030555|interpro:IPR032422|interpro:IPR035964|rcsb pdb:1R0D|reactome:R-HSA-432722|reactome:R-HSA-8856828|go:"GO:0030665"(clathrin-coated vesicle membrane)	refseq:NP_003325.2|refseq:NP_695012.1|refseq:XP_016885269.1|refseq:XP_016885270.1|dip:DIP-33686N|ensembl:ENSG00000130985(gene)|ensembl:ENST00000335972(transcript)|ensembl:ENST00000377351(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0004839"(ubiquitin activating enzyme activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0032446"(protein modification by small protein conjugation)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000011(Ubiquitin-activating enzyme, E1)|interpro:IPR000594(UBA/THIF-type NAD/FAD binding fold)|interpro:IPR018074|interpro:IPR018075|interpro:IPR018965|interpro:IPR019572|interpro:IPR032418|interpro:IPR032420|interpro:IPR033127|interpro:IPR035985|interpro:IPR038252|interpro:IPR042063|interpro:IPR042302|interpro:IPR042449|mint:P22314|rcsb pdb:4P22|rcsb pdb:6DC6|reactome:R-HSA-8866652|reactome:R-HSA-983168	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S3|resulting-ptm:O75146 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:CnPCKHH1VcVfplrU2eR8WQ/+dho9606	rogid:q+vEeA0XLST0Zz173bmEt0dNbDE9606	intact-crc:B73940293CAD3BE6|rigid:Qwne4MW6aQXLnbq/loX7OqDxlFg	false	-	his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O75146	uniprotkb:P61088	intact:EBI-4402639|uniprotkb:A6NHQ6|uniprotkb:Q9UED9|uniprotkb:Q6NXG8|ensembl:ENSP00000253083	intact:EBI-1052908|uniprotkb:Q16781|uniprotkb:Q53Y81|ensembl:ENSP00000316176	psi-mi:hip1r_human(display_long)|uniprotkb:HIP1R(gene name)|psi-mi:HIP1R(display_short)|uniprotkb:HIP12(gene name synonym)|uniprotkb:KIAA0655(gene name synonym)|uniprotkb:Huntingtin-interacting protein 12(gene name synonym)	psi-mi:ube2n_human(display_long)|uniprotkb:Ubiquitin-protein ligase N(gene name synonym)|uniprotkb:Ubiquitin carrier protein N(gene name synonym)|uniprotkb:Ubc13(gene name synonym)|uniprotkb:Bendless-like ubiquitin-conjugating enzyme(gene name synonym)|uniprotkb:UBE2N(gene name)|psi-mi:UBE2N(display_short)|uniprotkb:BLU(gene name synonym)|uniprotkb:UbcH13(gene name synonym)|uniprotkb:E2 ubiquitin-conjugating enzyme N(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9971384|imex:IM-22822-69	author-confidence:Z-score = 7.84|author-confidence:Z-score = 7.92	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_003950.1|refseq:NP_001290026.1|dip:DIP-17042N|ensembl:ENST00000253083(transcript)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005547"(phosphatidylinositol-3,4,5-trisphosphate binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0005938"(cell cortex)|go:"GO:0006897"(endocytosis)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007015"(actin filament organization)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0030100"(regulation of endocytosis)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030276"(clathrin binding)|ensembl:ENSG00000130787(gene)|go:"GO:0030837"(negative regulation of actin filament polymerization)|go:"GO:0032051"(clathrin light chain binding)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0034316"(negative regulation of Arp2/3 complex-mediated actin nucleation)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0035615"(clathrin adaptor activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043197"(dendritic spine)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043325"(phosphatidylinositol-3,4-bisphosphate binding)|go:"GO:0045742"(positive regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048268"(clathrin coat assembly)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050821"(protein stabilization)|go:"GO:0051015"(actin filament binding)|go:"GO:0055123"(digestive system development)|go:"GO:0060453"(regulation of gastric acid secretion)|go:"GO:0080025"(phosphatidylinositol-3,5-bisphosphate binding)|go:"GO:0097060"(synaptic membrane)|go:"GO:1901030"(positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway)|go:"GO:1905445"(positive regulation of clathrin coat assembly)|go:"GO:2000369"(regulation of clathrin-dependent endocytosis)|go:"GO:2000588"(positive regulation of platelet-derived growth factor receptor-beta signaling pathway)|interpro:IPR002558(I/LWEQ)|interpro:IPR008942(ENTH/VHS)|interpro:IPR011417(ANTH)|interpro:IPR013809(Epsin-like, N-terminal)|interpro:IPR030224|interpro:IPR030555|interpro:IPR032422|interpro:IPR035964|rcsb pdb:1R0D|reactome:R-HSA-432722|reactome:R-HSA-8856828|go:"GO:0030665"(clathrin-coated vesicle membrane)	refseq:NP_003339.1|dip:DIP-29829N|ensembl:ENSG00000177889(gene)|ensembl:ENST00000318066(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000729"(DNA double-strand break processing)|go:"GO:0001650"(fibrillar center)|go:"GO:0003723"(RNA binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006282"(regulation of DNA repair)|go:"GO:0006301"(postreplication repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016574"(histone ubiquitination)|go:"GO:0031058"(positive regulation of histone modification)|go:"GO:0031372"(UBC13-MMS2 complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033182"(regulation of histone ubiquitination)|go:"GO:0035370"(UBC13-UEV1A complex)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0061631"(ubiquitin conjugating enzyme activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070534"(protein K63-linked ubiquitination)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|interpro:IPR023313|rcsb pdb:1J7D|rcsb pdb:2C2V|rcsb pdb:3HCT|rcsb pdb:3HCU|rcsb pdb:3VON|rcsb pdb:3W31|rcsb pdb:4DHI|rcsb pdb:4DHJ|rcsb pdb:4DHZ|rcsb pdb:4IP3|rcsb pdb:4NR3|rcsb pdb:4NRG|rcsb pdb:4NRI|rcsb pdb:4ONL|rcsb pdb:4ONM|rcsb pdb:4ONN|rcsb pdb:4ORH|rcsb pdb:4TKP|rcsb pdb:4WHV|rcsb pdb:5AIT|rcsb pdb:5AIU|rcsb pdb:5EYA|rcsb pdb:5H7S|rcsb pdb:5VNZ|rcsb pdb:5VO0|rcsb pdb:5YWR|rcsb pdb:6D6I|rcsb pdb:6JKY|rcsb pdb:6KFP|rcsb pdb:6KG6|rcsb pdb:6KL4|rcsb pdb:6LP2|rcsb pdb:6P5B|rcsb pdb:6S53|reactome:R-HSA-168927|reactome:R-HSA-202424|reactome:R-HSA-2871837|reactome:R-HSA-445989|reactome:R-HSA-450302|reactome:R-HSA-450321|reactome:R-HSA-5607764|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-5696395|reactome:R-HSA-69473|reactome:R-HSA-8866654|reactome:R-HSA-9020702|reactome:R-HSA-937039|reactome:R-HSA-937041|reactome:R-HSA-9646399|reactome:R-HSA-975110|reactome:R-HSA-975144|reactome:R-HSA-983168|rcsb pdb:6ULH|rcsb pdb:6UMP|rcsb pdb:6UMS|rcsb pdb:7BBD|rcsb pdb:7BBF|rcsb pdb:7BXG|reactome:R-HSA-1169408|reactome:R-HSA-168638	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S3|resulting-ptm:O75146 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:CnPCKHH1VcVfplrU2eR8WQ/+dho9606	rogid:dqdszHlq5FLPHC6UWX6uvkC6Yz89606	intact-crc:B73940293CAD3BE6|rigid:Qwne4MW6aQXLnbq/loX7OqDxlFg	false	-	his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q62925	uniprotkb:O75886	intact:EBI-636664	intact:EBI-373258|uniprotkb:Q7LDQ0|uniprotkb:Q9UF58|uniprotkb:A8K8A0|uniprotkb:D3DPA1|ensembl:ENSP00000263904	psi-mi:m3k1_rat(display_long)|uniprotkb:MAPK/ERK kinase kinase 1(gene name synonym)|uniprotkb:Map3k1(gene name)|psi-mi:Map3k1(display_short)|uniprotkb:Mekk(gene name synonym)|uniprotkb:Mekk1(gene name synonym)	psi-mi:stam2_human(display_long)|uniprotkb:STAM2(gene name)|psi-mi:STAM2(display_short)|uniprotkb:HBP(gene name synonym)|uniprotkb:Hrs-binding protein(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9971460|imex:IM-22822-72	author-confidence:Z-score = 8.84	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:620966|refseq:NP_446339.1|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR007527(Zinc finger, SWIM-type)|go:"GO:0000165"(MAPK cascade)|interpro:IPR016024(Armadillo-type fold)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0002011"(morphogenesis of an epithelial sheet)|go:"GO:0003382"(epithelial cell morphogenesis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004706"(JUN kinase kinase kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007254"(JNK cascade)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008432"(JUN kinase binding)|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0016020"(membrane)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0031434"(mitogen-activated protein kinase kinase binding)|go:"GO:0031941"(filamentous actin)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0042060"(wound healing)|go:"GO:0043010"(camera-type eye development)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046625"(sphingolipid binding)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050434"(positive regulation of viral transcription)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0061029"(eyelid development in camera-type eye)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|reactome:R-RNO-166058|reactome:R-RNO-2871796|reactome:R-RNO-975138|reactome:R-RNO-975871|interpro:IPR011989(Armadillo-like helical)|mint:Q62925	refseq:NP_005834.4|ensembl:ENSG00000115145(gene)|ensembl:ENST00000263904(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007165"(signal transduction)|go:"GO:0015031"(protein transport)|go:"GO:0016236"(macroautophagy)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0031901"(early endosome membrane)|go:"GO:0033565"(ESCRT-0 complex)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0036258"(multivesicular body assembly)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|interpro:IPR001452(Src homology-3)|interpro:IPR002014(VHS)|interpro:IPR003903(Ubiquitin interacting motif)|interpro:IPR008942(ENTH/VHS)|interpro:IPR035675|interpro:IPR036028|mint:O75886|rcsb pdb:1X2Q|rcsb pdb:1X5B|rcsb pdb:2L0T|rcsb pdb:5CRV|rcsb pdb:5IXF|reactome:R-HSA-182971|reactome:R-HSA-5689880|reactome:R-HSA-6807004|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-8875360|reactome:R-HSA-9013420|reactome:R-HSA-917729	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S3|resulting-ptm:O75886 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:EwhjYjowkZIAt4UyPcZBUtf9uak10116	rogid:e5brcAWS5So29SdnZV3cAm/dZAk9606	intact-crc:7BB75331ED4265AE|rigid:U/0SnjDNk4PN8J85SFDuepk9hWo	false	sufficient binding region:433-481(IPR013083)	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q62925	uniprotkb:Q13404	intact:EBI-636664	intact:EBI-1050671|uniprotkb:Q13403|uniprotkb:Q13532|uniprotkb:Q96H34|uniprotkb:Q9GZT0|uniprotkb:Q9GZW1|uniprotkb:Q9H4J3|uniprotkb:Q9H4J4|uniprotkb:Q9UKL1|uniprotkb:Q9UM48|uniprotkb:Q9UM49|uniprotkb:Q9UM50|uniprotkb:Q5TGE3|uniprotkb:E1P629|uniprotkb:Q5TGE0|ensembl:ENSP00000360739	psi-mi:m3k1_rat(display_long)|uniprotkb:MAPK/ERK kinase kinase 1(gene name synonym)|uniprotkb:Map3k1(gene name)|psi-mi:Map3k1(display_short)|uniprotkb:Mekk(gene name synonym)|uniprotkb:Mekk1(gene name synonym)	psi-mi:ub2v1_human(display_long)|uniprotkb:CROC-1(gene name synonym)|uniprotkb:TRAF6-regulated IKK activator 1 beta Uev1A(gene name synonym)|uniprotkb:P/OKcl.19(orf name)|uniprotkb:UBE2V1(gene name)|psi-mi:UBE2V1(display_short)|uniprotkb:CROC1(gene name synonym)|uniprotkb:UBE2V(gene name synonym)|uniprotkb:UEV1(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9971460|imex:IM-22822-72	author-confidence:Z-score = 8.84	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:620966|refseq:NP_446339.1|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR007527(Zinc finger, SWIM-type)|go:"GO:0000165"(MAPK cascade)|interpro:IPR016024(Armadillo-type fold)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0002011"(morphogenesis of an epithelial sheet)|go:"GO:0003382"(epithelial cell morphogenesis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004706"(JUN kinase kinase kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007254"(JNK cascade)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008432"(JUN kinase binding)|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0016020"(membrane)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0031434"(mitogen-activated protein kinase kinase binding)|go:"GO:0031941"(filamentous actin)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0042060"(wound healing)|go:"GO:0043010"(camera-type eye development)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046625"(sphingolipid binding)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050434"(positive regulation of viral transcription)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0061029"(eyelid development in camera-type eye)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|reactome:R-RNO-166058|reactome:R-RNO-2871796|reactome:R-RNO-975138|reactome:R-RNO-975871|interpro:IPR011989(Armadillo-like helical)|mint:Q62925	refseq:NP_001027459.1|refseq:NP_068823.2|refseq:NP_071887.1|refseq:NP_954595.1|refseq:NP_954673.1|refseq:NP_001244322.1|refseq:NP_001244323.1|refseq:NP_001244325.1|ensembl:ENSG00000244687(gene)|ensembl:ENST00000371674(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006282"(regulation of DNA repair)|go:"GO:0006301"(postreplication repair)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0030154"(cell differentiation)|go:"GO:0031371"(ubiquitin conjugating enzyme complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035370"(UBC13-UEV1A complex)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070534"(protein K63-linked ubiquitination)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|rcsb pdb:2A4D|rcsb pdb:2C2V|rcsb pdb:2HLW|rcsb pdb:6D6I|reactome:R-HSA-168638|reactome:R-HSA-168927|reactome:R-HSA-202424|reactome:R-HSA-2871837|reactome:R-HSA-445989|reactome:R-HSA-450302|reactome:R-HSA-450321|reactome:R-HSA-5607764|reactome:R-HSA-9020702|reactome:R-HSA-937039|reactome:R-HSA-937041|reactome:R-HSA-9646399|reactome:R-HSA-975110|reactome:R-HSA-975144|reactome:R-HSA-983168|dip:DIP-41911N	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S3|resulting-ptm:O75886 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:EwhjYjowkZIAt4UyPcZBUtf9uak10116	rogid:x95N7Dj2KIqu5gySX59xLmfthUg9606	intact-crc:7BB75331ED4265AE|rigid:U/0SnjDNk4PN8J85SFDuepk9hWo	false	sufficient binding region:433-481(IPR013083)	his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q62925	uniprotkb:P22314	intact:EBI-636664	intact:EBI-709688|uniprotkb:Q96E13|uniprotkb:Q5JRR8|ensembl:ENSP00000338413|ensembl:ENSP00000366568	psi-mi:m3k1_rat(display_long)|uniprotkb:MAPK/ERK kinase kinase 1(gene name synonym)|uniprotkb:Map3k1(gene name)|psi-mi:Map3k1(display_short)|uniprotkb:Mekk(gene name synonym)|uniprotkb:Mekk1(gene name synonym)	psi-mi:uba1_human(display_long)|uniprotkb:Ubiquitin-activating enzyme E1(gene name synonym)|uniprotkb:Protein A1S9(gene name synonym)|uniprotkb:UBA1(gene name)|psi-mi:UBA1(display_short)|uniprotkb:A1S9T(gene name synonym)|uniprotkb:UBE1(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9971460|imex:IM-22822-72	author-confidence:Z-score = 8.84	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:620966|refseq:NP_446339.1|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR007527(Zinc finger, SWIM-type)|go:"GO:0000165"(MAPK cascade)|interpro:IPR016024(Armadillo-type fold)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0002011"(morphogenesis of an epithelial sheet)|go:"GO:0003382"(epithelial cell morphogenesis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004706"(JUN kinase kinase kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007254"(JNK cascade)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008432"(JUN kinase binding)|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0016020"(membrane)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0031434"(mitogen-activated protein kinase kinase binding)|go:"GO:0031941"(filamentous actin)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0042060"(wound healing)|go:"GO:0043010"(camera-type eye development)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046625"(sphingolipid binding)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050434"(positive regulation of viral transcription)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0061029"(eyelid development in camera-type eye)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|reactome:R-RNO-166058|reactome:R-RNO-2871796|reactome:R-RNO-975138|reactome:R-RNO-975871|interpro:IPR011989(Armadillo-like helical)|mint:Q62925	refseq:NP_003325.2|refseq:NP_695012.1|refseq:XP_016885269.1|refseq:XP_016885270.1|dip:DIP-33686N|ensembl:ENSG00000130985(gene)|ensembl:ENST00000335972(transcript)|ensembl:ENST00000377351(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0004839"(ubiquitin activating enzyme activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0032446"(protein modification by small protein conjugation)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000011(Ubiquitin-activating enzyme, E1)|interpro:IPR000594(UBA/THIF-type NAD/FAD binding fold)|interpro:IPR018074|interpro:IPR018075|interpro:IPR018965|interpro:IPR019572|interpro:IPR032418|interpro:IPR032420|interpro:IPR033127|interpro:IPR035985|interpro:IPR038252|interpro:IPR042063|interpro:IPR042302|interpro:IPR042449|mint:P22314|rcsb pdb:4P22|rcsb pdb:6DC6|reactome:R-HSA-8866652|reactome:R-HSA-983168	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S3|resulting-ptm:O75886 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:EwhjYjowkZIAt4UyPcZBUtf9uak10116	rogid:q+vEeA0XLST0Zz173bmEt0dNbDE9606	intact-crc:7BB75331ED4265AE|rigid:U/0SnjDNk4PN8J85SFDuepk9hWo	false	sufficient binding region:433-481(IPR013083)	his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q62925	uniprotkb:P61088	intact:EBI-636664	intact:EBI-1052908|uniprotkb:Q16781|uniprotkb:Q53Y81|ensembl:ENSP00000316176	psi-mi:m3k1_rat(display_long)|uniprotkb:MAPK/ERK kinase kinase 1(gene name synonym)|uniprotkb:Map3k1(gene name)|psi-mi:Map3k1(display_short)|uniprotkb:Mekk(gene name synonym)|uniprotkb:Mekk1(gene name synonym)	psi-mi:ube2n_human(display_long)|uniprotkb:Ubiquitin-protein ligase N(gene name synonym)|uniprotkb:Ubiquitin carrier protein N(gene name synonym)|uniprotkb:Ubc13(gene name synonym)|uniprotkb:Bendless-like ubiquitin-conjugating enzyme(gene name synonym)|uniprotkb:UBE2N(gene name)|psi-mi:UBE2N(display_short)|uniprotkb:BLU(gene name synonym)|uniprotkb:UbcH13(gene name synonym)|uniprotkb:E2 ubiquitin-conjugating enzyme N(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9971460|imex:IM-22822-72	author-confidence:Z-score = 8.84	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:620966|refseq:NP_446339.1|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR007527(Zinc finger, SWIM-type)|go:"GO:0000165"(MAPK cascade)|interpro:IPR016024(Armadillo-type fold)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0002011"(morphogenesis of an epithelial sheet)|go:"GO:0003382"(epithelial cell morphogenesis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004706"(JUN kinase kinase kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007254"(JNK cascade)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008432"(JUN kinase binding)|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0016020"(membrane)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0031434"(mitogen-activated protein kinase kinase binding)|go:"GO:0031941"(filamentous actin)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0042060"(wound healing)|go:"GO:0043010"(camera-type eye development)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046625"(sphingolipid binding)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050434"(positive regulation of viral transcription)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0061029"(eyelid development in camera-type eye)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|reactome:R-RNO-166058|reactome:R-RNO-2871796|reactome:R-RNO-975138|reactome:R-RNO-975871|interpro:IPR011989(Armadillo-like helical)|mint:Q62925	refseq:NP_003339.1|dip:DIP-29829N|ensembl:ENSG00000177889(gene)|ensembl:ENST00000318066(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000729"(DNA double-strand break processing)|go:"GO:0001650"(fibrillar center)|go:"GO:0003723"(RNA binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006282"(regulation of DNA repair)|go:"GO:0006301"(postreplication repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016574"(histone ubiquitination)|go:"GO:0031058"(positive regulation of histone modification)|go:"GO:0031372"(UBC13-MMS2 complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033182"(regulation of histone ubiquitination)|go:"GO:0035370"(UBC13-UEV1A complex)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0061631"(ubiquitin conjugating enzyme activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070534"(protein K63-linked ubiquitination)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|interpro:IPR023313|rcsb pdb:1J7D|rcsb pdb:2C2V|rcsb pdb:3HCT|rcsb pdb:3HCU|rcsb pdb:3VON|rcsb pdb:3W31|rcsb pdb:4DHI|rcsb pdb:4DHJ|rcsb pdb:4DHZ|rcsb pdb:4IP3|rcsb pdb:4NR3|rcsb pdb:4NRG|rcsb pdb:4NRI|rcsb pdb:4ONL|rcsb pdb:4ONM|rcsb pdb:4ONN|rcsb pdb:4ORH|rcsb pdb:4TKP|rcsb pdb:4WHV|rcsb pdb:5AIT|rcsb pdb:5AIU|rcsb pdb:5EYA|rcsb pdb:5H7S|rcsb pdb:5VNZ|rcsb pdb:5VO0|rcsb pdb:5YWR|rcsb pdb:6D6I|rcsb pdb:6JKY|rcsb pdb:6KFP|rcsb pdb:6KG6|rcsb pdb:6KL4|rcsb pdb:6LP2|rcsb pdb:6P5B|rcsb pdb:6S53|reactome:R-HSA-168927|reactome:R-HSA-202424|reactome:R-HSA-2871837|reactome:R-HSA-445989|reactome:R-HSA-450302|reactome:R-HSA-450321|reactome:R-HSA-5607764|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-5696395|reactome:R-HSA-69473|reactome:R-HSA-8866654|reactome:R-HSA-9020702|reactome:R-HSA-937039|reactome:R-HSA-937041|reactome:R-HSA-9646399|reactome:R-HSA-975110|reactome:R-HSA-975144|reactome:R-HSA-983168|rcsb pdb:6ULH|rcsb pdb:6UMP|rcsb pdb:6UMS|rcsb pdb:7BBD|rcsb pdb:7BBF|rcsb pdb:7BXG|reactome:R-HSA-1169408|reactome:R-HSA-168638	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S3|resulting-ptm:O75886 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:EwhjYjowkZIAt4UyPcZBUtf9uak10116	rogid:dqdszHlq5FLPHC6UWX6uvkC6Yz89606	intact-crc:7BB75331ED4265AE|rigid:U/0SnjDNk4PN8J85SFDuepk9hWo	false	sufficient binding region:433-481(IPR013083)	his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O75344	uniprotkb:Q62925	intact:EBI-744771|uniprotkb:Q9UDS0|ensembl:ENSP00000252037|uniprotkb:B4DXT7|uniprotkb:G3V0I2|uniprotkb:Q7Z4T4	intact:EBI-636664	psi-mi:fkbp6_human(display_long)|uniprotkb:FK506-binding protein 6(gene name synonym)|uniprotkb:36 kDa FK506-binding protein(gene name synonym)|uniprotkb:Immunophilin FKBP36(gene name synonym)|uniprotkb:FKBP6(gene name)|psi-mi:FKBP6(display_short)|uniprotkb:FKBP36(gene name synonym)	psi-mi:m3k1_rat(display_long)|uniprotkb:MAPK/ERK kinase kinase 1(gene name synonym)|uniprotkb:Map3k1(gene name)|psi-mi:Map3k1(display_short)|uniprotkb:Mekk(gene name synonym)|uniprotkb:Mekk1(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9971435|imex:IM-22822-71	author-confidence:Z-score = 10.78	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_003593.3|ensembl:ENSG00000077800(gene)|ensembl:ENST00000252037(transcript)|go:"GO:0000413"(protein peptidyl-prolyl isomerization)|go:"GO:0000795"(synaptonemal complex)|go:"GO:0005528"(FK506 binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0007283"(spermatogenesis)|go:"GO:0030154"(cell differentiation)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0034587"(piRNA metabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043046"(DNA methylation involved in gamete generation)|go:"GO:0045070"(positive regulation of viral genome replication)|go:"GO:0051321"(meiotic cell cycle)|go:"GO:0051879"(Hsp90 protein binding)|interpro:IPR001179(Peptidyl-prolyl cis-trans isomerase, FKBP-type)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR042282|rcsb pdb:3B7X|reactome:R-HSA-1221632|reactome:R-HSA-5601884|refseq:NP_001128683.1|refseq:NP_001268233.1	rgd:620966|refseq:NP_446339.1|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR007527(Zinc finger, SWIM-type)|go:"GO:0000165"(MAPK cascade)|interpro:IPR016024(Armadillo-type fold)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0002011"(morphogenesis of an epithelial sheet)|go:"GO:0003382"(epithelial cell morphogenesis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004706"(JUN kinase kinase kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007254"(JNK cascade)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008432"(JUN kinase binding)|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0016020"(membrane)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0031434"(mitogen-activated protein kinase kinase binding)|go:"GO:0031941"(filamentous actin)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0042060"(wound healing)|go:"GO:0043010"(camera-type eye development)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046625"(sphingolipid binding)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050434"(positive regulation of viral transcription)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0061029"(eyelid development in camera-type eye)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|reactome:R-RNO-166058|reactome:R-RNO-2871796|reactome:R-RNO-975138|reactome:R-RNO-975871|interpro:IPR011989(Armadillo-like helical)|mint:Q62925	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S3|resulting-ptm:O75344 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:eTZEJks6RqGNmT2RKvRYaZQnl7o9606	rogid:EwhjYjowkZIAt4UyPcZBUtf9uak10116	intact-crc:BA24D2C93DEE38FA|rigid:aAifgiABDtkYJbAlG04/3mJH7Ds	false	-	sufficient binding region:433-481(IPR013083)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O75344	uniprotkb:Q13404	intact:EBI-744771|uniprotkb:Q9UDS0|ensembl:ENSP00000252037|uniprotkb:B4DXT7|uniprotkb:G3V0I2|uniprotkb:Q7Z4T4	intact:EBI-1050671|uniprotkb:Q13403|uniprotkb:Q13532|uniprotkb:Q96H34|uniprotkb:Q9GZT0|uniprotkb:Q9GZW1|uniprotkb:Q9H4J3|uniprotkb:Q9H4J4|uniprotkb:Q9UKL1|uniprotkb:Q9UM48|uniprotkb:Q9UM49|uniprotkb:Q9UM50|uniprotkb:Q5TGE3|uniprotkb:E1P629|uniprotkb:Q5TGE0|ensembl:ENSP00000360739	psi-mi:fkbp6_human(display_long)|uniprotkb:FK506-binding protein 6(gene name synonym)|uniprotkb:36 kDa FK506-binding protein(gene name synonym)|uniprotkb:Immunophilin FKBP36(gene name synonym)|uniprotkb:FKBP6(gene name)|psi-mi:FKBP6(display_short)|uniprotkb:FKBP36(gene name synonym)	psi-mi:ub2v1_human(display_long)|uniprotkb:CROC-1(gene name synonym)|uniprotkb:TRAF6-regulated IKK activator 1 beta Uev1A(gene name synonym)|uniprotkb:P/OKcl.19(orf name)|uniprotkb:UBE2V1(gene name)|psi-mi:UBE2V1(display_short)|uniprotkb:CROC1(gene name synonym)|uniprotkb:UBE2V(gene name synonym)|uniprotkb:UEV1(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9971435|imex:IM-22822-71	author-confidence:Z-score = 10.78	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_003593.3|ensembl:ENSG00000077800(gene)|ensembl:ENST00000252037(transcript)|go:"GO:0000413"(protein peptidyl-prolyl isomerization)|go:"GO:0000795"(synaptonemal complex)|go:"GO:0005528"(FK506 binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0007283"(spermatogenesis)|go:"GO:0030154"(cell differentiation)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0034587"(piRNA metabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043046"(DNA methylation involved in gamete generation)|go:"GO:0045070"(positive regulation of viral genome replication)|go:"GO:0051321"(meiotic cell cycle)|go:"GO:0051879"(Hsp90 protein binding)|interpro:IPR001179(Peptidyl-prolyl cis-trans isomerase, FKBP-type)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR042282|rcsb pdb:3B7X|reactome:R-HSA-1221632|reactome:R-HSA-5601884|refseq:NP_001128683.1|refseq:NP_001268233.1	refseq:NP_001027459.1|refseq:NP_068823.2|refseq:NP_071887.1|refseq:NP_954595.1|refseq:NP_954673.1|refseq:NP_001244322.1|refseq:NP_001244323.1|refseq:NP_001244325.1|ensembl:ENSG00000244687(gene)|ensembl:ENST00000371674(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006282"(regulation of DNA repair)|go:"GO:0006301"(postreplication repair)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0030154"(cell differentiation)|go:"GO:0031371"(ubiquitin conjugating enzyme complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035370"(UBC13-UEV1A complex)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070534"(protein K63-linked ubiquitination)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|rcsb pdb:2A4D|rcsb pdb:2C2V|rcsb pdb:2HLW|rcsb pdb:6D6I|reactome:R-HSA-168638|reactome:R-HSA-168927|reactome:R-HSA-202424|reactome:R-HSA-2871837|reactome:R-HSA-445989|reactome:R-HSA-450302|reactome:R-HSA-450321|reactome:R-HSA-5607764|reactome:R-HSA-9020702|reactome:R-HSA-937039|reactome:R-HSA-937041|reactome:R-HSA-9646399|reactome:R-HSA-975110|reactome:R-HSA-975144|reactome:R-HSA-983168|dip:DIP-41911N	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S3|resulting-ptm:O75344 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:eTZEJks6RqGNmT2RKvRYaZQnl7o9606	rogid:x95N7Dj2KIqu5gySX59xLmfthUg9606	intact-crc:BA24D2C93DEE38FA|rigid:aAifgiABDtkYJbAlG04/3mJH7Ds	false	-	his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O75344	uniprotkb:P22314	intact:EBI-744771|uniprotkb:Q9UDS0|ensembl:ENSP00000252037|uniprotkb:B4DXT7|uniprotkb:G3V0I2|uniprotkb:Q7Z4T4	intact:EBI-709688|uniprotkb:Q96E13|uniprotkb:Q5JRR8|ensembl:ENSP00000338413|ensembl:ENSP00000366568	psi-mi:fkbp6_human(display_long)|uniprotkb:FK506-binding protein 6(gene name synonym)|uniprotkb:36 kDa FK506-binding protein(gene name synonym)|uniprotkb:Immunophilin FKBP36(gene name synonym)|uniprotkb:FKBP6(gene name)|psi-mi:FKBP6(display_short)|uniprotkb:FKBP36(gene name synonym)	psi-mi:uba1_human(display_long)|uniprotkb:Ubiquitin-activating enzyme E1(gene name synonym)|uniprotkb:Protein A1S9(gene name synonym)|uniprotkb:UBA1(gene name)|psi-mi:UBA1(display_short)|uniprotkb:A1S9T(gene name synonym)|uniprotkb:UBE1(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9971435|imex:IM-22822-71	author-confidence:Z-score = 10.78	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_003593.3|ensembl:ENSG00000077800(gene)|ensembl:ENST00000252037(transcript)|go:"GO:0000413"(protein peptidyl-prolyl isomerization)|go:"GO:0000795"(synaptonemal complex)|go:"GO:0005528"(FK506 binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0007283"(spermatogenesis)|go:"GO:0030154"(cell differentiation)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0034587"(piRNA metabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043046"(DNA methylation involved in gamete generation)|go:"GO:0045070"(positive regulation of viral genome replication)|go:"GO:0051321"(meiotic cell cycle)|go:"GO:0051879"(Hsp90 protein binding)|interpro:IPR001179(Peptidyl-prolyl cis-trans isomerase, FKBP-type)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR042282|rcsb pdb:3B7X|reactome:R-HSA-1221632|reactome:R-HSA-5601884|refseq:NP_001128683.1|refseq:NP_001268233.1	refseq:NP_003325.2|refseq:NP_695012.1|refseq:XP_016885269.1|refseq:XP_016885270.1|dip:DIP-33686N|ensembl:ENSG00000130985(gene)|ensembl:ENST00000335972(transcript)|ensembl:ENST00000377351(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0004839"(ubiquitin activating enzyme activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0032446"(protein modification by small protein conjugation)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000011(Ubiquitin-activating enzyme, E1)|interpro:IPR000594(UBA/THIF-type NAD/FAD binding fold)|interpro:IPR018074|interpro:IPR018075|interpro:IPR018965|interpro:IPR019572|interpro:IPR032418|interpro:IPR032420|interpro:IPR033127|interpro:IPR035985|interpro:IPR038252|interpro:IPR042063|interpro:IPR042302|interpro:IPR042449|mint:P22314|rcsb pdb:4P22|rcsb pdb:6DC6|reactome:R-HSA-8866652|reactome:R-HSA-983168	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S3|resulting-ptm:O75344 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:eTZEJks6RqGNmT2RKvRYaZQnl7o9606	rogid:q+vEeA0XLST0Zz173bmEt0dNbDE9606	intact-crc:BA24D2C93DEE38FA|rigid:aAifgiABDtkYJbAlG04/3mJH7Ds	false	-	his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O75344	uniprotkb:P61088	intact:EBI-744771|uniprotkb:Q9UDS0|ensembl:ENSP00000252037|uniprotkb:B4DXT7|uniprotkb:G3V0I2|uniprotkb:Q7Z4T4	intact:EBI-1052908|uniprotkb:Q16781|uniprotkb:Q53Y81|ensembl:ENSP00000316176	psi-mi:fkbp6_human(display_long)|uniprotkb:FK506-binding protein 6(gene name synonym)|uniprotkb:36 kDa FK506-binding protein(gene name synonym)|uniprotkb:Immunophilin FKBP36(gene name synonym)|uniprotkb:FKBP6(gene name)|psi-mi:FKBP6(display_short)|uniprotkb:FKBP36(gene name synonym)	psi-mi:ube2n_human(display_long)|uniprotkb:Ubiquitin-protein ligase N(gene name synonym)|uniprotkb:Ubiquitin carrier protein N(gene name synonym)|uniprotkb:Ubc13(gene name synonym)|uniprotkb:Bendless-like ubiquitin-conjugating enzyme(gene name synonym)|uniprotkb:UBE2N(gene name)|psi-mi:UBE2N(display_short)|uniprotkb:BLU(gene name synonym)|uniprotkb:UbcH13(gene name synonym)|uniprotkb:E2 ubiquitin-conjugating enzyme N(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9971435|imex:IM-22822-71	author-confidence:Z-score = 10.78	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_003593.3|ensembl:ENSG00000077800(gene)|ensembl:ENST00000252037(transcript)|go:"GO:0000413"(protein peptidyl-prolyl isomerization)|go:"GO:0000795"(synaptonemal complex)|go:"GO:0005528"(FK506 binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0007283"(spermatogenesis)|go:"GO:0030154"(cell differentiation)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0034587"(piRNA metabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043046"(DNA methylation involved in gamete generation)|go:"GO:0045070"(positive regulation of viral genome replication)|go:"GO:0051321"(meiotic cell cycle)|go:"GO:0051879"(Hsp90 protein binding)|interpro:IPR001179(Peptidyl-prolyl cis-trans isomerase, FKBP-type)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR042282|rcsb pdb:3B7X|reactome:R-HSA-1221632|reactome:R-HSA-5601884|refseq:NP_001128683.1|refseq:NP_001268233.1	refseq:NP_003339.1|dip:DIP-29829N|ensembl:ENSG00000177889(gene)|ensembl:ENST00000318066(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000729"(DNA double-strand break processing)|go:"GO:0001650"(fibrillar center)|go:"GO:0003723"(RNA binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006282"(regulation of DNA repair)|go:"GO:0006301"(postreplication repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016574"(histone ubiquitination)|go:"GO:0031058"(positive regulation of histone modification)|go:"GO:0031372"(UBC13-MMS2 complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033182"(regulation of histone ubiquitination)|go:"GO:0035370"(UBC13-UEV1A complex)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0061631"(ubiquitin conjugating enzyme activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070534"(protein K63-linked ubiquitination)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|interpro:IPR023313|rcsb pdb:1J7D|rcsb pdb:2C2V|rcsb pdb:3HCT|rcsb pdb:3HCU|rcsb pdb:3VON|rcsb pdb:3W31|rcsb pdb:4DHI|rcsb pdb:4DHJ|rcsb pdb:4DHZ|rcsb pdb:4IP3|rcsb pdb:4NR3|rcsb pdb:4NRG|rcsb pdb:4NRI|rcsb pdb:4ONL|rcsb pdb:4ONM|rcsb pdb:4ONN|rcsb pdb:4ORH|rcsb pdb:4TKP|rcsb pdb:4WHV|rcsb pdb:5AIT|rcsb pdb:5AIU|rcsb pdb:5EYA|rcsb pdb:5H7S|rcsb pdb:5VNZ|rcsb pdb:5VO0|rcsb pdb:5YWR|rcsb pdb:6D6I|rcsb pdb:6JKY|rcsb pdb:6KFP|rcsb pdb:6KG6|rcsb pdb:6KL4|rcsb pdb:6LP2|rcsb pdb:6P5B|rcsb pdb:6S53|reactome:R-HSA-168927|reactome:R-HSA-202424|reactome:R-HSA-2871837|reactome:R-HSA-445989|reactome:R-HSA-450302|reactome:R-HSA-450321|reactome:R-HSA-5607764|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-5696395|reactome:R-HSA-69473|reactome:R-HSA-8866654|reactome:R-HSA-9020702|reactome:R-HSA-937039|reactome:R-HSA-937041|reactome:R-HSA-9646399|reactome:R-HSA-975110|reactome:R-HSA-975144|reactome:R-HSA-983168|rcsb pdb:6ULH|rcsb pdb:6UMP|rcsb pdb:6UMS|rcsb pdb:7BBD|rcsb pdb:7BBF|rcsb pdb:7BXG|reactome:R-HSA-1169408|reactome:R-HSA-168638	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S3|resulting-ptm:O75344 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:eTZEJks6RqGNmT2RKvRYaZQnl7o9606	rogid:dqdszHlq5FLPHC6UWX6uvkC6Yz89606	intact-crc:BA24D2C93DEE38FA|rigid:aAifgiABDtkYJbAlG04/3mJH7Ds	false	-	his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O76013	uniprotkb:Q62925	intact:EBI-1054946|uniprotkb:Q86XG4|ensembl:ENSP00000329165	intact:EBI-636664	psi-mi:krt36_human(display_long)|uniprotkb:KRTHA6(gene name synonym)|uniprotkb:Hair keratin, type I Ha6(gene name synonym)|uniprotkb:Keratin-36(gene name synonym)|uniprotkb:KRT36(gene name)|psi-mi:KRT36(display_short)|uniprotkb:HHA6(gene name synonym)|uniprotkb:HKA6(gene name synonym)	psi-mi:m3k1_rat(display_long)|uniprotkb:MAPK/ERK kinase kinase 1(gene name synonym)|uniprotkb:Map3k1(gene name)|psi-mi:Map3k1(display_short)|uniprotkb:Mekk(gene name synonym)|uniprotkb:Mekk1(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9971485|imex:IM-22822-73	author-confidence:Z-score = 4.14	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_003762.1|ensembl:ENSG00000126337(gene)|ensembl:ENST00000328119(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0005882"(intermediate filament)|go:"GO:0030280"(structural constituent of skin epidermis)|go:"GO:0045616"(regulation of keratinocyte differentiation)|go:"GO:0070062"(extracellular exosome)|interpro:IPR002957(Keratin, type I)|interpro:IPR018039|interpro:IPR039008|reactome:R-HSA-6805567|reactome:R-HSA-6809371	rgd:620966|refseq:NP_446339.1|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR007527(Zinc finger, SWIM-type)|go:"GO:0000165"(MAPK cascade)|interpro:IPR016024(Armadillo-type fold)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0002011"(morphogenesis of an epithelial sheet)|go:"GO:0003382"(epithelial cell morphogenesis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004706"(JUN kinase kinase kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007254"(JNK cascade)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008432"(JUN kinase binding)|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0016020"(membrane)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0031434"(mitogen-activated protein kinase kinase binding)|go:"GO:0031941"(filamentous actin)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0042060"(wound healing)|go:"GO:0043010"(camera-type eye development)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046625"(sphingolipid binding)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050434"(positive regulation of viral transcription)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0061029"(eyelid development in camera-type eye)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|reactome:R-RNO-166058|reactome:R-RNO-2871796|reactome:R-RNO-975138|reactome:R-RNO-975871|interpro:IPR011989(Armadillo-like helical)|mint:Q62925	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S3|resulting-ptm:O76013 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:T3L08n7jEhsouGDkQuK0jBLanBQ9606	rogid:EwhjYjowkZIAt4UyPcZBUtf9uak10116	intact-crc:4467ECCE78444F9E|rigid:+/QQLmHlvRZmcMtJn5bZ16nTY3Y	false	-	sufficient binding region:433-481(IPR013083)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O76013	uniprotkb:Q13404	intact:EBI-1054946|uniprotkb:Q86XG4|ensembl:ENSP00000329165	intact:EBI-1050671|uniprotkb:Q13403|uniprotkb:Q13532|uniprotkb:Q96H34|uniprotkb:Q9GZT0|uniprotkb:Q9GZW1|uniprotkb:Q9H4J3|uniprotkb:Q9H4J4|uniprotkb:Q9UKL1|uniprotkb:Q9UM48|uniprotkb:Q9UM49|uniprotkb:Q9UM50|uniprotkb:Q5TGE3|uniprotkb:E1P629|uniprotkb:Q5TGE0|ensembl:ENSP00000360739	psi-mi:krt36_human(display_long)|uniprotkb:KRTHA6(gene name synonym)|uniprotkb:Hair keratin, type I Ha6(gene name synonym)|uniprotkb:Keratin-36(gene name synonym)|uniprotkb:KRT36(gene name)|psi-mi:KRT36(display_short)|uniprotkb:HHA6(gene name synonym)|uniprotkb:HKA6(gene name synonym)	psi-mi:ub2v1_human(display_long)|uniprotkb:CROC-1(gene name synonym)|uniprotkb:TRAF6-regulated IKK activator 1 beta Uev1A(gene name synonym)|uniprotkb:P/OKcl.19(orf name)|uniprotkb:UBE2V1(gene name)|psi-mi:UBE2V1(display_short)|uniprotkb:CROC1(gene name synonym)|uniprotkb:UBE2V(gene name synonym)|uniprotkb:UEV1(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9971485|imex:IM-22822-73	author-confidence:Z-score = 4.14	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_003762.1|ensembl:ENSG00000126337(gene)|ensembl:ENST00000328119(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0005882"(intermediate filament)|go:"GO:0030280"(structural constituent of skin epidermis)|go:"GO:0045616"(regulation of keratinocyte differentiation)|go:"GO:0070062"(extracellular exosome)|interpro:IPR002957(Keratin, type I)|interpro:IPR018039|interpro:IPR039008|reactome:R-HSA-6805567|reactome:R-HSA-6809371	refseq:NP_001027459.1|refseq:NP_068823.2|refseq:NP_071887.1|refseq:NP_954595.1|refseq:NP_954673.1|refseq:NP_001244322.1|refseq:NP_001244323.1|refseq:NP_001244325.1|ensembl:ENSG00000244687(gene)|ensembl:ENST00000371674(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006282"(regulation of DNA repair)|go:"GO:0006301"(postreplication repair)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0030154"(cell differentiation)|go:"GO:0031371"(ubiquitin conjugating enzyme complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035370"(UBC13-UEV1A complex)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070534"(protein K63-linked ubiquitination)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|rcsb pdb:2A4D|rcsb pdb:2C2V|rcsb pdb:2HLW|rcsb pdb:6D6I|reactome:R-HSA-168638|reactome:R-HSA-168927|reactome:R-HSA-202424|reactome:R-HSA-2871837|reactome:R-HSA-445989|reactome:R-HSA-450302|reactome:R-HSA-450321|reactome:R-HSA-5607764|reactome:R-HSA-9020702|reactome:R-HSA-937039|reactome:R-HSA-937041|reactome:R-HSA-9646399|reactome:R-HSA-975110|reactome:R-HSA-975144|reactome:R-HSA-983168|dip:DIP-41911N	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S3|resulting-ptm:O76013 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:T3L08n7jEhsouGDkQuK0jBLanBQ9606	rogid:x95N7Dj2KIqu5gySX59xLmfthUg9606	intact-crc:4467ECCE78444F9E|rigid:+/QQLmHlvRZmcMtJn5bZ16nTY3Y	false	-	his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O76013	uniprotkb:P22314	intact:EBI-1054946|uniprotkb:Q86XG4|ensembl:ENSP00000329165	intact:EBI-709688|uniprotkb:Q96E13|uniprotkb:Q5JRR8|ensembl:ENSP00000338413|ensembl:ENSP00000366568	psi-mi:krt36_human(display_long)|uniprotkb:KRTHA6(gene name synonym)|uniprotkb:Hair keratin, type I Ha6(gene name synonym)|uniprotkb:Keratin-36(gene name synonym)|uniprotkb:KRT36(gene name)|psi-mi:KRT36(display_short)|uniprotkb:HHA6(gene name synonym)|uniprotkb:HKA6(gene name synonym)	psi-mi:uba1_human(display_long)|uniprotkb:Ubiquitin-activating enzyme E1(gene name synonym)|uniprotkb:Protein A1S9(gene name synonym)|uniprotkb:UBA1(gene name)|psi-mi:UBA1(display_short)|uniprotkb:A1S9T(gene name synonym)|uniprotkb:UBE1(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9971485|imex:IM-22822-73	author-confidence:Z-score = 4.14	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_003762.1|ensembl:ENSG00000126337(gene)|ensembl:ENST00000328119(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0005882"(intermediate filament)|go:"GO:0030280"(structural constituent of skin epidermis)|go:"GO:0045616"(regulation of keratinocyte differentiation)|go:"GO:0070062"(extracellular exosome)|interpro:IPR002957(Keratin, type I)|interpro:IPR018039|interpro:IPR039008|reactome:R-HSA-6805567|reactome:R-HSA-6809371	refseq:NP_003325.2|refseq:NP_695012.1|refseq:XP_016885269.1|refseq:XP_016885270.1|dip:DIP-33686N|ensembl:ENSG00000130985(gene)|ensembl:ENST00000335972(transcript)|ensembl:ENST00000377351(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0004839"(ubiquitin activating enzyme activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0032446"(protein modification by small protein conjugation)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000011(Ubiquitin-activating enzyme, E1)|interpro:IPR000594(UBA/THIF-type NAD/FAD binding fold)|interpro:IPR018074|interpro:IPR018075|interpro:IPR018965|interpro:IPR019572|interpro:IPR032418|interpro:IPR032420|interpro:IPR033127|interpro:IPR035985|interpro:IPR038252|interpro:IPR042063|interpro:IPR042302|interpro:IPR042449|mint:P22314|rcsb pdb:4P22|rcsb pdb:6DC6|reactome:R-HSA-8866652|reactome:R-HSA-983168	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S3|resulting-ptm:O76013 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:T3L08n7jEhsouGDkQuK0jBLanBQ9606	rogid:q+vEeA0XLST0Zz173bmEt0dNbDE9606	intact-crc:4467ECCE78444F9E|rigid:+/QQLmHlvRZmcMtJn5bZ16nTY3Y	false	-	his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O76013	uniprotkb:P61088	intact:EBI-1054946|uniprotkb:Q86XG4|ensembl:ENSP00000329165	intact:EBI-1052908|uniprotkb:Q16781|uniprotkb:Q53Y81|ensembl:ENSP00000316176	psi-mi:krt36_human(display_long)|uniprotkb:KRTHA6(gene name synonym)|uniprotkb:Hair keratin, type I Ha6(gene name synonym)|uniprotkb:Keratin-36(gene name synonym)|uniprotkb:KRT36(gene name)|psi-mi:KRT36(display_short)|uniprotkb:HHA6(gene name synonym)|uniprotkb:HKA6(gene name synonym)	psi-mi:ube2n_human(display_long)|uniprotkb:Ubiquitin-protein ligase N(gene name synonym)|uniprotkb:Ubiquitin carrier protein N(gene name synonym)|uniprotkb:Ubc13(gene name synonym)|uniprotkb:Bendless-like ubiquitin-conjugating enzyme(gene name synonym)|uniprotkb:UBE2N(gene name)|psi-mi:UBE2N(display_short)|uniprotkb:BLU(gene name synonym)|uniprotkb:UbcH13(gene name synonym)|uniprotkb:E2 ubiquitin-conjugating enzyme N(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9971485|imex:IM-22822-73	author-confidence:Z-score = 4.14	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_003762.1|ensembl:ENSG00000126337(gene)|ensembl:ENST00000328119(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0005882"(intermediate filament)|go:"GO:0030280"(structural constituent of skin epidermis)|go:"GO:0045616"(regulation of keratinocyte differentiation)|go:"GO:0070062"(extracellular exosome)|interpro:IPR002957(Keratin, type I)|interpro:IPR018039|interpro:IPR039008|reactome:R-HSA-6805567|reactome:R-HSA-6809371	refseq:NP_003339.1|dip:DIP-29829N|ensembl:ENSG00000177889(gene)|ensembl:ENST00000318066(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000729"(DNA double-strand break processing)|go:"GO:0001650"(fibrillar center)|go:"GO:0003723"(RNA binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006282"(regulation of DNA repair)|go:"GO:0006301"(postreplication repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016574"(histone ubiquitination)|go:"GO:0031058"(positive regulation of histone modification)|go:"GO:0031372"(UBC13-MMS2 complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033182"(regulation of histone ubiquitination)|go:"GO:0035370"(UBC13-UEV1A complex)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0061631"(ubiquitin conjugating enzyme activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070534"(protein K63-linked ubiquitination)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|interpro:IPR023313|rcsb pdb:1J7D|rcsb pdb:2C2V|rcsb pdb:3HCT|rcsb pdb:3HCU|rcsb pdb:3VON|rcsb pdb:3W31|rcsb pdb:4DHI|rcsb pdb:4DHJ|rcsb pdb:4DHZ|rcsb pdb:4IP3|rcsb pdb:4NR3|rcsb pdb:4NRG|rcsb pdb:4NRI|rcsb pdb:4ONL|rcsb pdb:4ONM|rcsb pdb:4ONN|rcsb pdb:4ORH|rcsb pdb:4TKP|rcsb pdb:4WHV|rcsb pdb:5AIT|rcsb pdb:5AIU|rcsb pdb:5EYA|rcsb pdb:5H7S|rcsb pdb:5VNZ|rcsb pdb:5VO0|rcsb pdb:5YWR|rcsb pdb:6D6I|rcsb pdb:6JKY|rcsb pdb:6KFP|rcsb pdb:6KG6|rcsb pdb:6KL4|rcsb pdb:6LP2|rcsb pdb:6P5B|rcsb pdb:6S53|reactome:R-HSA-168927|reactome:R-HSA-202424|reactome:R-HSA-2871837|reactome:R-HSA-445989|reactome:R-HSA-450302|reactome:R-HSA-450321|reactome:R-HSA-5607764|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-5696395|reactome:R-HSA-69473|reactome:R-HSA-8866654|reactome:R-HSA-9020702|reactome:R-HSA-937039|reactome:R-HSA-937041|reactome:R-HSA-9646399|reactome:R-HSA-975110|reactome:R-HSA-975144|reactome:R-HSA-983168|rcsb pdb:6ULH|rcsb pdb:6UMP|rcsb pdb:6UMS|rcsb pdb:7BBD|rcsb pdb:7BBF|rcsb pdb:7BXG|reactome:R-HSA-1169408|reactome:R-HSA-168638	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S3|resulting-ptm:O76013 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:T3L08n7jEhsouGDkQuK0jBLanBQ9606	rogid:dqdszHlq5FLPHC6UWX6uvkC6Yz89606	intact-crc:4467ECCE78444F9E|rigid:+/QQLmHlvRZmcMtJn5bZ16nTY3Y	false	-	his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q62925	uniprotkb:Q13404	intact:EBI-636664	intact:EBI-1050671|uniprotkb:Q13403|uniprotkb:Q13532|uniprotkb:Q96H34|uniprotkb:Q9GZT0|uniprotkb:Q9GZW1|uniprotkb:Q9H4J3|uniprotkb:Q9H4J4|uniprotkb:Q9UKL1|uniprotkb:Q9UM48|uniprotkb:Q9UM49|uniprotkb:Q9UM50|uniprotkb:Q5TGE3|uniprotkb:E1P629|uniprotkb:Q5TGE0|ensembl:ENSP00000360739	psi-mi:m3k1_rat(display_long)|uniprotkb:MAPK/ERK kinase kinase 1(gene name synonym)|uniprotkb:Map3k1(gene name)|psi-mi:Map3k1(display_short)|uniprotkb:Mekk(gene name synonym)|uniprotkb:Mekk1(gene name synonym)	psi-mi:ub2v1_human(display_long)|uniprotkb:CROC-1(gene name synonym)|uniprotkb:TRAF6-regulated IKK activator 1 beta Uev1A(gene name synonym)|uniprotkb:P/OKcl.19(orf name)|uniprotkb:UBE2V1(gene name)|psi-mi:UBE2V1(display_short)|uniprotkb:CROC1(gene name synonym)|uniprotkb:UBE2V(gene name synonym)|uniprotkb:UEV1(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9971510|imex:IM-22822-74	author-confidence:Z-score = 10.77	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:620966|refseq:NP_446339.1|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR007527(Zinc finger, SWIM-type)|go:"GO:0000165"(MAPK cascade)|interpro:IPR016024(Armadillo-type fold)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0002011"(morphogenesis of an epithelial sheet)|go:"GO:0003382"(epithelial cell morphogenesis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004706"(JUN kinase kinase kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007254"(JNK cascade)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008432"(JUN kinase binding)|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0016020"(membrane)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0031434"(mitogen-activated protein kinase kinase binding)|go:"GO:0031941"(filamentous actin)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0042060"(wound healing)|go:"GO:0043010"(camera-type eye development)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046625"(sphingolipid binding)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050434"(positive regulation of viral transcription)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0061029"(eyelid development in camera-type eye)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|reactome:R-RNO-166058|reactome:R-RNO-2871796|reactome:R-RNO-975138|reactome:R-RNO-975871|interpro:IPR011989(Armadillo-like helical)|mint:Q62925	refseq:NP_001027459.1|refseq:NP_068823.2|refseq:NP_071887.1|refseq:NP_954595.1|refseq:NP_954673.1|refseq:NP_001244322.1|refseq:NP_001244323.1|refseq:NP_001244325.1|ensembl:ENSG00000244687(gene)|ensembl:ENST00000371674(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006282"(regulation of DNA repair)|go:"GO:0006301"(postreplication repair)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0030154"(cell differentiation)|go:"GO:0031371"(ubiquitin conjugating enzyme complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035370"(UBC13-UEV1A complex)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070534"(protein K63-linked ubiquitination)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|rcsb pdb:2A4D|rcsb pdb:2C2V|rcsb pdb:2HLW|rcsb pdb:6D6I|reactome:R-HSA-168638|reactome:R-HSA-168927|reactome:R-HSA-202424|reactome:R-HSA-2871837|reactome:R-HSA-445989|reactome:R-HSA-450302|reactome:R-HSA-450321|reactome:R-HSA-5607764|reactome:R-HSA-9020702|reactome:R-HSA-937039|reactome:R-HSA-937041|reactome:R-HSA-9646399|reactome:R-HSA-975110|reactome:R-HSA-975144|reactome:R-HSA-983168|dip:DIP-41911N	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S3|resulting-ptm:O76080 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:EwhjYjowkZIAt4UyPcZBUtf9uak10116	rogid:x95N7Dj2KIqu5gySX59xLmfthUg9606	intact-crc:A97962C207AF1F6A|rigid:U+x5uwy85UjVZ25BdGS0FuAmg9c	false	sufficient binding region:433-481(IPR013083)	his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q62925	uniprotkb:P22314	intact:EBI-636664	intact:EBI-709688|uniprotkb:Q96E13|uniprotkb:Q5JRR8|ensembl:ENSP00000338413|ensembl:ENSP00000366568	psi-mi:m3k1_rat(display_long)|uniprotkb:MAPK/ERK kinase kinase 1(gene name synonym)|uniprotkb:Map3k1(gene name)|psi-mi:Map3k1(display_short)|uniprotkb:Mekk(gene name synonym)|uniprotkb:Mekk1(gene name synonym)	psi-mi:uba1_human(display_long)|uniprotkb:Ubiquitin-activating enzyme E1(gene name synonym)|uniprotkb:Protein A1S9(gene name synonym)|uniprotkb:UBA1(gene name)|psi-mi:UBA1(display_short)|uniprotkb:A1S9T(gene name synonym)|uniprotkb:UBE1(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9971510|imex:IM-22822-74	author-confidence:Z-score = 10.77	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:620966|refseq:NP_446339.1|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR007527(Zinc finger, SWIM-type)|go:"GO:0000165"(MAPK cascade)|interpro:IPR016024(Armadillo-type fold)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0002011"(morphogenesis of an epithelial sheet)|go:"GO:0003382"(epithelial cell morphogenesis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004706"(JUN kinase kinase kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007254"(JNK cascade)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008432"(JUN kinase binding)|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0016020"(membrane)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0031434"(mitogen-activated protein kinase kinase binding)|go:"GO:0031941"(filamentous actin)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0042060"(wound healing)|go:"GO:0043010"(camera-type eye development)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046625"(sphingolipid binding)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050434"(positive regulation of viral transcription)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0061029"(eyelid development in camera-type eye)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|reactome:R-RNO-166058|reactome:R-RNO-2871796|reactome:R-RNO-975138|reactome:R-RNO-975871|interpro:IPR011989(Armadillo-like helical)|mint:Q62925	refseq:NP_003325.2|refseq:NP_695012.1|refseq:XP_016885269.1|refseq:XP_016885270.1|dip:DIP-33686N|ensembl:ENSG00000130985(gene)|ensembl:ENST00000335972(transcript)|ensembl:ENST00000377351(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0004839"(ubiquitin activating enzyme activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0032446"(protein modification by small protein conjugation)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000011(Ubiquitin-activating enzyme, E1)|interpro:IPR000594(UBA/THIF-type NAD/FAD binding fold)|interpro:IPR018074|interpro:IPR018075|interpro:IPR018965|interpro:IPR019572|interpro:IPR032418|interpro:IPR032420|interpro:IPR033127|interpro:IPR035985|interpro:IPR038252|interpro:IPR042063|interpro:IPR042302|interpro:IPR042449|mint:P22314|rcsb pdb:4P22|rcsb pdb:6DC6|reactome:R-HSA-8866652|reactome:R-HSA-983168	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S3|resulting-ptm:O76080 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:EwhjYjowkZIAt4UyPcZBUtf9uak10116	rogid:q+vEeA0XLST0Zz173bmEt0dNbDE9606	intact-crc:A97962C207AF1F6A|rigid:U+x5uwy85UjVZ25BdGS0FuAmg9c	false	sufficient binding region:433-481(IPR013083)	his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q62925	uniprotkb:P61088	intact:EBI-636664	intact:EBI-1052908|uniprotkb:Q16781|uniprotkb:Q53Y81|ensembl:ENSP00000316176	psi-mi:m3k1_rat(display_long)|uniprotkb:MAPK/ERK kinase kinase 1(gene name synonym)|uniprotkb:Map3k1(gene name)|psi-mi:Map3k1(display_short)|uniprotkb:Mekk(gene name synonym)|uniprotkb:Mekk1(gene name synonym)	psi-mi:ube2n_human(display_long)|uniprotkb:Ubiquitin-protein ligase N(gene name synonym)|uniprotkb:Ubiquitin carrier protein N(gene name synonym)|uniprotkb:Ubc13(gene name synonym)|uniprotkb:Bendless-like ubiquitin-conjugating enzyme(gene name synonym)|uniprotkb:UBE2N(gene name)|psi-mi:UBE2N(display_short)|uniprotkb:BLU(gene name synonym)|uniprotkb:UbcH13(gene name synonym)|uniprotkb:E2 ubiquitin-conjugating enzyme N(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9971510|imex:IM-22822-74	author-confidence:Z-score = 10.77	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:620966|refseq:NP_446339.1|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR007527(Zinc finger, SWIM-type)|go:"GO:0000165"(MAPK cascade)|interpro:IPR016024(Armadillo-type fold)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0002011"(morphogenesis of an epithelial sheet)|go:"GO:0003382"(epithelial cell morphogenesis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004706"(JUN kinase kinase kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007254"(JNK cascade)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008432"(JUN kinase binding)|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0016020"(membrane)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0031434"(mitogen-activated protein kinase kinase binding)|go:"GO:0031941"(filamentous actin)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0042060"(wound healing)|go:"GO:0043010"(camera-type eye development)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046625"(sphingolipid binding)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050434"(positive regulation of viral transcription)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0061029"(eyelid development in camera-type eye)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|reactome:R-RNO-166058|reactome:R-RNO-2871796|reactome:R-RNO-975138|reactome:R-RNO-975871|interpro:IPR011989(Armadillo-like helical)|mint:Q62925	refseq:NP_003339.1|dip:DIP-29829N|ensembl:ENSG00000177889(gene)|ensembl:ENST00000318066(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000729"(DNA double-strand break processing)|go:"GO:0001650"(fibrillar center)|go:"GO:0003723"(RNA binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006282"(regulation of DNA repair)|go:"GO:0006301"(postreplication repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016574"(histone ubiquitination)|go:"GO:0031058"(positive regulation of histone modification)|go:"GO:0031372"(UBC13-MMS2 complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033182"(regulation of histone ubiquitination)|go:"GO:0035370"(UBC13-UEV1A complex)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0061631"(ubiquitin conjugating enzyme activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070534"(protein K63-linked ubiquitination)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|interpro:IPR023313|rcsb pdb:1J7D|rcsb pdb:2C2V|rcsb pdb:3HCT|rcsb pdb:3HCU|rcsb pdb:3VON|rcsb pdb:3W31|rcsb pdb:4DHI|rcsb pdb:4DHJ|rcsb pdb:4DHZ|rcsb pdb:4IP3|rcsb pdb:4NR3|rcsb pdb:4NRG|rcsb pdb:4NRI|rcsb pdb:4ONL|rcsb pdb:4ONM|rcsb pdb:4ONN|rcsb pdb:4ORH|rcsb pdb:4TKP|rcsb pdb:4WHV|rcsb pdb:5AIT|rcsb pdb:5AIU|rcsb pdb:5EYA|rcsb pdb:5H7S|rcsb pdb:5VNZ|rcsb pdb:5VO0|rcsb pdb:5YWR|rcsb pdb:6D6I|rcsb pdb:6JKY|rcsb pdb:6KFP|rcsb pdb:6KG6|rcsb pdb:6KL4|rcsb pdb:6LP2|rcsb pdb:6P5B|rcsb pdb:6S53|reactome:R-HSA-168927|reactome:R-HSA-202424|reactome:R-HSA-2871837|reactome:R-HSA-445989|reactome:R-HSA-450302|reactome:R-HSA-450321|reactome:R-HSA-5607764|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-5696395|reactome:R-HSA-69473|reactome:R-HSA-8866654|reactome:R-HSA-9020702|reactome:R-HSA-937039|reactome:R-HSA-937041|reactome:R-HSA-9646399|reactome:R-HSA-975110|reactome:R-HSA-975144|reactome:R-HSA-983168|rcsb pdb:6ULH|rcsb pdb:6UMP|rcsb pdb:6UMS|rcsb pdb:7BBD|rcsb pdb:7BBF|rcsb pdb:7BXG|reactome:R-HSA-1169408|reactome:R-HSA-168638	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S3|resulting-ptm:O76080 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:EwhjYjowkZIAt4UyPcZBUtf9uak10116	rogid:dqdszHlq5FLPHC6UWX6uvkC6Yz89606	intact-crc:A97962C207AF1F6A|rigid:U+x5uwy85UjVZ25BdGS0FuAmg9c	false	sufficient binding region:433-481(IPR013083)	his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q62925	uniprotkb:O76080	intact:EBI-636664	intact:EBI-8028844|uniprotkb:A8K484|intact:MINT-1958864|ensembl:ENSP00000237937|ensembl:ENSP00000350586|ensembl:ENSP00000366159|ensembl:ENSP00000366161	psi-mi:m3k1_rat(display_long)|uniprotkb:MAPK/ERK kinase kinase 1(gene name synonym)|uniprotkb:Map3k1(gene name)|psi-mi:Map3k1(display_short)|uniprotkb:Mekk(gene name synonym)|uniprotkb:Mekk1(gene name synonym)	psi-mi:zfan5_human(display_long)|uniprotkb:ZNF216(gene name synonym)|uniprotkb:ZFAND5(gene name)|psi-mi:ZFAND5(display_short)|uniprotkb:ZA20D2(gene name synonym)|uniprotkb:Zinc finger protein 216(gene name synonym)|uniprotkb:Zinc finger A20 domain-containing protein 2(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9971510|imex:IM-22822-74	author-confidence:Z-score = 10.77	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:620966|refseq:NP_446339.1|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR007527(Zinc finger, SWIM-type)|go:"GO:0000165"(MAPK cascade)|interpro:IPR016024(Armadillo-type fold)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0002011"(morphogenesis of an epithelial sheet)|go:"GO:0003382"(epithelial cell morphogenesis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004706"(JUN kinase kinase kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007254"(JNK cascade)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008432"(JUN kinase binding)|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0016020"(membrane)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0031434"(mitogen-activated protein kinase kinase binding)|go:"GO:0031941"(filamentous actin)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0042060"(wound healing)|go:"GO:0043010"(camera-type eye development)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046625"(sphingolipid binding)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050434"(positive regulation of viral transcription)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0061029"(eyelid development in camera-type eye)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|reactome:R-RNO-166058|reactome:R-RNO-2871796|reactome:R-RNO-975138|reactome:R-RNO-975871|interpro:IPR011989(Armadillo-like helical)|mint:Q62925	refseq:NP_001095890.1|refseq:NP_001095891.1|refseq:NP_005998.1|refseq:NP_001265172.1|refseq:NP_001265173.1|refseq:NP_001265174.1|ensembl:ENSG00000107372(gene)|ensembl:ENST00000237937(transcript)|ensembl:ENST00000343431(transcript)|ensembl:ENST00000376960(transcript)|ensembl:ENST00000376962(transcript)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001944"(vasculature development)|go:"GO:0003016"(respiratory system process)|go:"GO:0003677"(DNA binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010761"(fibroblast migration)|go:"GO:0048008"(platelet-derived growth factor receptor signaling pathway)|go:"GO:0048705"(skeletal system morphogenesis)|go:"GO:0048745"(smooth muscle tissue development)|go:"GO:0060324"(face development)|interpro:IPR000058(Zinc finger, AN1-type)|interpro:IPR002653(Zinc finger, A20-type)|interpro:IPR035896|mint:O76080	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	comment:mint	figure legend:Table S3|resulting-ptm:O76080 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:EwhjYjowkZIAt4UyPcZBUtf9uak10116	rogid:0SuLQ7JPu3KBaE4uWHXMC9D3nbA9606	intact-crc:A97962C207AF1F6A|rigid:U+x5uwy85UjVZ25BdGS0FuAmg9c	false	sufficient binding region:433-481(IPR013083)	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P04233	uniprotkb:Q62925	intact:EBI-2622890|uniprotkb:D3DQG3|uniprotkb:D3DQG4|uniprotkb:A8K7R1|uniprotkb:B4DNE8|uniprotkb:Q29832|uniprotkb:Q14597|uniprotkb:Q8SNA0|uniprotkb:Q8WLP6|uniprotkb:Q5U0J8|ensembl:ENSP00000009530	intact:EBI-636664	psi-mi:hg2a_human(display_long)|uniprotkb:DHLAG(gene name synonym)|uniprotkb:HLA-DR antigens-associated invariant chain(gene name synonym)|uniprotkb:Ia antigen-associated invariant chain(gene name synonym)|uniprotkb:CD74(gene name)|psi-mi:CD74(display_short)	psi-mi:m3k1_rat(display_long)|uniprotkb:MAPK/ERK kinase kinase 1(gene name synonym)|uniprotkb:Map3k1(gene name)|psi-mi:Map3k1(display_short)|uniprotkb:Mekk(gene name synonym)|uniprotkb:Mekk1(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9971560|imex:IM-22822-76	author-confidence:Z-score = 10.76	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001020329.1|refseq:NP_001020330.1|refseq:NP_004346.1|ensembl:ENSG00000019582(gene)|ensembl:ENST00000009530(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001516"(prostaglandin biosynthetic process)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001961"(positive regulation of cytokine-mediated signaling pathway)|go:"GO:0002286"(T cell activation involved in immune response)|go:"GO:0002606"(positive regulation of dendritic cell antigen processing and presentation)|go:"GO:0002792"(negative regulation of peptide secretion)|go:"GO:0002830"(positive regulation of type 2 immune response)|go:"GO:0002906"(negative regulation of mature B cell apoptotic process)|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005770"(late endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005773"(vacuole)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0008283"(cell population proliferation)|go:"GO:0009986"(cell surface)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016064"(immunoglobulin mediated immune response)|go:"GO:0019882"(antigen processing and presentation)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0019883"(antigen processing and presentation of endogenous antigen)|go:"GO:0019886"(antigen processing and presentation of exogenous peptide antigen via MHC class II)|go:"GO:0019955"(cytokine binding)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0031394"(positive regulation of prostaglandin biosynthetic process)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0034341"(response to interferon-gamma)|go:"GO:0035691"(macrophage migration inhibitory factor signaling pathway)|go:"GO:0035692"(macrophage migration inhibitory factor receptor complex)|go:"GO:0035693"(NOS2-CD74 complex)|go:"GO:0035718"(macrophage migration inhibitory factor binding)|go:"GO:0042289"(MHC class II protein binding)|go:"GO:0042609"(CD4 receptor binding)|go:"GO:0042613"(MHC class II protein complex)|go:"GO:0042658"(MHC class II protein binding, via antigen binding groove)|go:"GO:0042802"(identical protein binding)|go:"GO:0043030"(regulation of macrophage activation)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043518"(negative regulation of DNA damage response, signal transduction by p53 class mediator)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0045058"(T cell selection)|go:"GO:0045059"(positive thymic T cell selection)|go:"GO:0045060"(negative thymic T cell selection)|go:"GO:0045581"(negative regulation of T cell differentiation)|go:"GO:0045582"(positive regulation of T cell differentiation)|go:"GO:0045657"(positive regulation of monocyte differentiation)|go:"GO:0071556"(integral component of lumenal side of endoplasmic reticulum membrane)|go:"GO:0090023"(positive regulation of neutrophil chemotaxis)|go:"GO:1902166"(negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:2000343"("positive regulation of chemokine (C-X-C motif) ligand 2 production")|go:"GO:2000448"(positive regulation of macrophage migration inhibitory factor signaling pathway)|interpro:IPR000716(Thyroglobulin type-1)|interpro:IPR011988(MHC class II-associated invariant chain, trimerisation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|interpro:IPR015386(MHC class II-associated invariant chain/CLIP, MHC II-interacting)|interpro:IPR022339|interpro:IPR036613|go:"GO:0046597"(negative regulation of viral entry into host cell)|interpro:IPR036857|interpro:IPR043530|mint:P04233|rcsb pdb:1A6A|rcsb pdb:1ICF|rcsb pdb:1IIE|rcsb pdb:1L3H|rcsb pdb:1MUJ|rcsb pdb:3PDO|rcsb pdb:3PGC|rcsb pdb:3PGD|go:"GO:0046598"(positive regulation of viral entry into host cell)|rcsb pdb:3QXA|go:"GO:0048146"(positive regulation of fibroblast proliferation)|rcsb pdb:3QXD|rcsb pdb:4AEN|rcsb pdb:4AH2|rcsb pdb:4X5W|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|rcsb pdb:5KSU|rcsb pdb:5KSV|go:"GO:0050821"(protein stabilization)|reactome:R-HSA-202733|reactome:R-HSA-2132295|go:"GO:0050998"(nitric-oxide synthase binding)|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0060907"(positive regulation of macrophage cytokine production)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070206"(protein trimerization)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)	rgd:620966|refseq:NP_446339.1|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR007527(Zinc finger, SWIM-type)|go:"GO:0000165"(MAPK cascade)|interpro:IPR016024(Armadillo-type fold)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0002011"(morphogenesis of an epithelial sheet)|go:"GO:0003382"(epithelial cell morphogenesis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004706"(JUN kinase kinase kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007254"(JNK cascade)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008432"(JUN kinase binding)|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0016020"(membrane)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0031434"(mitogen-activated protein kinase kinase binding)|go:"GO:0031941"(filamentous actin)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0042060"(wound healing)|go:"GO:0043010"(camera-type eye development)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046625"(sphingolipid binding)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050434"(positive regulation of viral transcription)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0061029"(eyelid development in camera-type eye)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|reactome:R-RNO-166058|reactome:R-RNO-2871796|reactome:R-RNO-975138|reactome:R-RNO-975871|interpro:IPR011989(Armadillo-like helical)|mint:Q62925	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S3|resulting-ptm:P04233 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:jP1UH09kpXY45O7Qr5OdAfDDIXY9606	rogid:EwhjYjowkZIAt4UyPcZBUtf9uak10116	intact-crc:3D266AAE43529A3B|rigid:6sNyd9/yZm+Uys4Ichfp5ZxrdMU	false	-	sufficient binding region:433-481(IPR013083)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P04233	uniprotkb:Q13404	intact:EBI-2622890|uniprotkb:D3DQG3|uniprotkb:D3DQG4|uniprotkb:A8K7R1|uniprotkb:B4DNE8|uniprotkb:Q29832|uniprotkb:Q14597|uniprotkb:Q8SNA0|uniprotkb:Q8WLP6|uniprotkb:Q5U0J8|ensembl:ENSP00000009530	intact:EBI-1050671|uniprotkb:Q13403|uniprotkb:Q13532|uniprotkb:Q96H34|uniprotkb:Q9GZT0|uniprotkb:Q9GZW1|uniprotkb:Q9H4J3|uniprotkb:Q9H4J4|uniprotkb:Q9UKL1|uniprotkb:Q9UM48|uniprotkb:Q9UM49|uniprotkb:Q9UM50|uniprotkb:Q5TGE3|uniprotkb:E1P629|uniprotkb:Q5TGE0|ensembl:ENSP00000360739	psi-mi:hg2a_human(display_long)|uniprotkb:DHLAG(gene name synonym)|uniprotkb:HLA-DR antigens-associated invariant chain(gene name synonym)|uniprotkb:Ia antigen-associated invariant chain(gene name synonym)|uniprotkb:CD74(gene name)|psi-mi:CD74(display_short)	psi-mi:ub2v1_human(display_long)|uniprotkb:CROC-1(gene name synonym)|uniprotkb:TRAF6-regulated IKK activator 1 beta Uev1A(gene name synonym)|uniprotkb:P/OKcl.19(orf name)|uniprotkb:UBE2V1(gene name)|psi-mi:UBE2V1(display_short)|uniprotkb:CROC1(gene name synonym)|uniprotkb:UBE2V(gene name synonym)|uniprotkb:UEV1(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9971560|imex:IM-22822-76	author-confidence:Z-score = 10.76	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001020329.1|refseq:NP_001020330.1|refseq:NP_004346.1|ensembl:ENSG00000019582(gene)|ensembl:ENST00000009530(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001516"(prostaglandin biosynthetic process)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001961"(positive regulation of cytokine-mediated signaling pathway)|go:"GO:0002286"(T cell activation involved in immune response)|go:"GO:0002606"(positive regulation of dendritic cell antigen processing and presentation)|go:"GO:0002792"(negative regulation of peptide secretion)|go:"GO:0002830"(positive regulation of type 2 immune response)|go:"GO:0002906"(negative regulation of mature B cell apoptotic process)|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005770"(late endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005773"(vacuole)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0008283"(cell population proliferation)|go:"GO:0009986"(cell surface)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016064"(immunoglobulin mediated immune response)|go:"GO:0019882"(antigen processing and presentation)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0019883"(antigen processing and presentation of endogenous antigen)|go:"GO:0019886"(antigen processing and presentation of exogenous peptide antigen via MHC class II)|go:"GO:0019955"(cytokine binding)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0031394"(positive regulation of prostaglandin biosynthetic process)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0034341"(response to interferon-gamma)|go:"GO:0035691"(macrophage migration inhibitory factor signaling pathway)|go:"GO:0035692"(macrophage migration inhibitory factor receptor complex)|go:"GO:0035693"(NOS2-CD74 complex)|go:"GO:0035718"(macrophage migration inhibitory factor binding)|go:"GO:0042289"(MHC class II protein binding)|go:"GO:0042609"(CD4 receptor binding)|go:"GO:0042613"(MHC class II protein complex)|go:"GO:0042658"(MHC class II protein binding, via antigen binding groove)|go:"GO:0042802"(identical protein binding)|go:"GO:0043030"(regulation of macrophage activation)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043518"(negative regulation of DNA damage response, signal transduction by p53 class mediator)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0045058"(T cell selection)|go:"GO:0045059"(positive thymic T cell selection)|go:"GO:0045060"(negative thymic T cell selection)|go:"GO:0045581"(negative regulation of T cell differentiation)|go:"GO:0045582"(positive regulation of T cell differentiation)|go:"GO:0045657"(positive regulation of monocyte differentiation)|go:"GO:0071556"(integral component of lumenal side of endoplasmic reticulum membrane)|go:"GO:0090023"(positive regulation of neutrophil chemotaxis)|go:"GO:1902166"(negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:2000343"("positive regulation of chemokine (C-X-C motif) ligand 2 production")|go:"GO:2000448"(positive regulation of macrophage migration inhibitory factor signaling pathway)|interpro:IPR000716(Thyroglobulin type-1)|interpro:IPR011988(MHC class II-associated invariant chain, trimerisation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|interpro:IPR015386(MHC class II-associated invariant chain/CLIP, MHC II-interacting)|interpro:IPR022339|interpro:IPR036613|go:"GO:0046597"(negative regulation of viral entry into host cell)|interpro:IPR036857|interpro:IPR043530|mint:P04233|rcsb pdb:1A6A|rcsb pdb:1ICF|rcsb pdb:1IIE|rcsb pdb:1L3H|rcsb pdb:1MUJ|rcsb pdb:3PDO|rcsb pdb:3PGC|rcsb pdb:3PGD|go:"GO:0046598"(positive regulation of viral entry into host cell)|rcsb pdb:3QXA|go:"GO:0048146"(positive regulation of fibroblast proliferation)|rcsb pdb:3QXD|rcsb pdb:4AEN|rcsb pdb:4AH2|rcsb pdb:4X5W|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|rcsb pdb:5KSU|rcsb pdb:5KSV|go:"GO:0050821"(protein stabilization)|reactome:R-HSA-202733|reactome:R-HSA-2132295|go:"GO:0050998"(nitric-oxide synthase binding)|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0060907"(positive regulation of macrophage cytokine production)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070206"(protein trimerization)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)	refseq:NP_001027459.1|refseq:NP_068823.2|refseq:NP_071887.1|refseq:NP_954595.1|refseq:NP_954673.1|refseq:NP_001244322.1|refseq:NP_001244323.1|refseq:NP_001244325.1|ensembl:ENSG00000244687(gene)|ensembl:ENST00000371674(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006282"(regulation of DNA repair)|go:"GO:0006301"(postreplication repair)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0030154"(cell differentiation)|go:"GO:0031371"(ubiquitin conjugating enzyme complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035370"(UBC13-UEV1A complex)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070534"(protein K63-linked ubiquitination)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|rcsb pdb:2A4D|rcsb pdb:2C2V|rcsb pdb:2HLW|rcsb pdb:6D6I|reactome:R-HSA-168638|reactome:R-HSA-168927|reactome:R-HSA-202424|reactome:R-HSA-2871837|reactome:R-HSA-445989|reactome:R-HSA-450302|reactome:R-HSA-450321|reactome:R-HSA-5607764|reactome:R-HSA-9020702|reactome:R-HSA-937039|reactome:R-HSA-937041|reactome:R-HSA-9646399|reactome:R-HSA-975110|reactome:R-HSA-975144|reactome:R-HSA-983168|dip:DIP-41911N	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S3|resulting-ptm:P04233 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:jP1UH09kpXY45O7Qr5OdAfDDIXY9606	rogid:x95N7Dj2KIqu5gySX59xLmfthUg9606	intact-crc:3D266AAE43529A3B|rigid:6sNyd9/yZm+Uys4Ichfp5ZxrdMU	false	-	his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P04233	uniprotkb:P22314	intact:EBI-2622890|uniprotkb:D3DQG3|uniprotkb:D3DQG4|uniprotkb:A8K7R1|uniprotkb:B4DNE8|uniprotkb:Q29832|uniprotkb:Q14597|uniprotkb:Q8SNA0|uniprotkb:Q8WLP6|uniprotkb:Q5U0J8|ensembl:ENSP00000009530	intact:EBI-709688|uniprotkb:Q96E13|uniprotkb:Q5JRR8|ensembl:ENSP00000338413|ensembl:ENSP00000366568	psi-mi:hg2a_human(display_long)|uniprotkb:DHLAG(gene name synonym)|uniprotkb:HLA-DR antigens-associated invariant chain(gene name synonym)|uniprotkb:Ia antigen-associated invariant chain(gene name synonym)|uniprotkb:CD74(gene name)|psi-mi:CD74(display_short)	psi-mi:uba1_human(display_long)|uniprotkb:Ubiquitin-activating enzyme E1(gene name synonym)|uniprotkb:Protein A1S9(gene name synonym)|uniprotkb:UBA1(gene name)|psi-mi:UBA1(display_short)|uniprotkb:A1S9T(gene name synonym)|uniprotkb:UBE1(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9971560|imex:IM-22822-76	author-confidence:Z-score = 10.76	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001020329.1|refseq:NP_001020330.1|refseq:NP_004346.1|ensembl:ENSG00000019582(gene)|ensembl:ENST00000009530(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001516"(prostaglandin biosynthetic process)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001961"(positive regulation of cytokine-mediated signaling pathway)|go:"GO:0002286"(T cell activation involved in immune response)|go:"GO:0002606"(positive regulation of dendritic cell antigen processing and presentation)|go:"GO:0002792"(negative regulation of peptide secretion)|go:"GO:0002830"(positive regulation of type 2 immune response)|go:"GO:0002906"(negative regulation of mature B cell apoptotic process)|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005770"(late endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005773"(vacuole)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0008283"(cell population proliferation)|go:"GO:0009986"(cell surface)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016064"(immunoglobulin mediated immune response)|go:"GO:0019882"(antigen processing and presentation)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0019883"(antigen processing and presentation of endogenous antigen)|go:"GO:0019886"(antigen processing and presentation of exogenous peptide antigen via MHC class II)|go:"GO:0019955"(cytokine binding)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0031394"(positive regulation of prostaglandin biosynthetic process)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0034341"(response to interferon-gamma)|go:"GO:0035691"(macrophage migration inhibitory factor signaling pathway)|go:"GO:0035692"(macrophage migration inhibitory factor receptor complex)|go:"GO:0035693"(NOS2-CD74 complex)|go:"GO:0035718"(macrophage migration inhibitory factor binding)|go:"GO:0042289"(MHC class II protein binding)|go:"GO:0042609"(CD4 receptor binding)|go:"GO:0042613"(MHC class II protein complex)|go:"GO:0042658"(MHC class II protein binding, via antigen binding groove)|go:"GO:0042802"(identical protein binding)|go:"GO:0043030"(regulation of macrophage activation)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043518"(negative regulation of DNA damage response, signal transduction by p53 class mediator)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0045058"(T cell selection)|go:"GO:0045059"(positive thymic T cell selection)|go:"GO:0045060"(negative thymic T cell selection)|go:"GO:0045581"(negative regulation of T cell differentiation)|go:"GO:0045582"(positive regulation of T cell differentiation)|go:"GO:0045657"(positive regulation of monocyte differentiation)|go:"GO:0071556"(integral component of lumenal side of endoplasmic reticulum membrane)|go:"GO:0090023"(positive regulation of neutrophil chemotaxis)|go:"GO:1902166"(negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:2000343"("positive regulation of chemokine (C-X-C motif) ligand 2 production")|go:"GO:2000448"(positive regulation of macrophage migration inhibitory factor signaling pathway)|interpro:IPR000716(Thyroglobulin type-1)|interpro:IPR011988(MHC class II-associated invariant chain, trimerisation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|interpro:IPR015386(MHC class II-associated invariant chain/CLIP, MHC II-interacting)|interpro:IPR022339|interpro:IPR036613|go:"GO:0046597"(negative regulation of viral entry into host cell)|interpro:IPR036857|interpro:IPR043530|mint:P04233|rcsb pdb:1A6A|rcsb pdb:1ICF|rcsb pdb:1IIE|rcsb pdb:1L3H|rcsb pdb:1MUJ|rcsb pdb:3PDO|rcsb pdb:3PGC|rcsb pdb:3PGD|go:"GO:0046598"(positive regulation of viral entry into host cell)|rcsb pdb:3QXA|go:"GO:0048146"(positive regulation of fibroblast proliferation)|rcsb pdb:3QXD|rcsb pdb:4AEN|rcsb pdb:4AH2|rcsb pdb:4X5W|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|rcsb pdb:5KSU|rcsb pdb:5KSV|go:"GO:0050821"(protein stabilization)|reactome:R-HSA-202733|reactome:R-HSA-2132295|go:"GO:0050998"(nitric-oxide synthase binding)|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0060907"(positive regulation of macrophage cytokine production)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070206"(protein trimerization)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)	refseq:NP_003325.2|refseq:NP_695012.1|refseq:XP_016885269.1|refseq:XP_016885270.1|dip:DIP-33686N|ensembl:ENSG00000130985(gene)|ensembl:ENST00000335972(transcript)|ensembl:ENST00000377351(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0004839"(ubiquitin activating enzyme activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0032446"(protein modification by small protein conjugation)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000011(Ubiquitin-activating enzyme, E1)|interpro:IPR000594(UBA/THIF-type NAD/FAD binding fold)|interpro:IPR018074|interpro:IPR018075|interpro:IPR018965|interpro:IPR019572|interpro:IPR032418|interpro:IPR032420|interpro:IPR033127|interpro:IPR035985|interpro:IPR038252|interpro:IPR042063|interpro:IPR042302|interpro:IPR042449|mint:P22314|rcsb pdb:4P22|rcsb pdb:6DC6|reactome:R-HSA-8866652|reactome:R-HSA-983168	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S3|resulting-ptm:P04233 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:jP1UH09kpXY45O7Qr5OdAfDDIXY9606	rogid:q+vEeA0XLST0Zz173bmEt0dNbDE9606	intact-crc:3D266AAE43529A3B|rigid:6sNyd9/yZm+Uys4Ichfp5ZxrdMU	false	-	his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P04233	uniprotkb:P61088	intact:EBI-2622890|uniprotkb:D3DQG3|uniprotkb:D3DQG4|uniprotkb:A8K7R1|uniprotkb:B4DNE8|uniprotkb:Q29832|uniprotkb:Q14597|uniprotkb:Q8SNA0|uniprotkb:Q8WLP6|uniprotkb:Q5U0J8|ensembl:ENSP00000009530	intact:EBI-1052908|uniprotkb:Q16781|uniprotkb:Q53Y81|ensembl:ENSP00000316176	psi-mi:hg2a_human(display_long)|uniprotkb:DHLAG(gene name synonym)|uniprotkb:HLA-DR antigens-associated invariant chain(gene name synonym)|uniprotkb:Ia antigen-associated invariant chain(gene name synonym)|uniprotkb:CD74(gene name)|psi-mi:CD74(display_short)	psi-mi:ube2n_human(display_long)|uniprotkb:Ubiquitin-protein ligase N(gene name synonym)|uniprotkb:Ubiquitin carrier protein N(gene name synonym)|uniprotkb:Ubc13(gene name synonym)|uniprotkb:Bendless-like ubiquitin-conjugating enzyme(gene name synonym)|uniprotkb:UBE2N(gene name)|psi-mi:UBE2N(display_short)|uniprotkb:BLU(gene name synonym)|uniprotkb:UbcH13(gene name synonym)|uniprotkb:E2 ubiquitin-conjugating enzyme N(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9971560|imex:IM-22822-76	author-confidence:Z-score = 10.76	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001020329.1|refseq:NP_001020330.1|refseq:NP_004346.1|ensembl:ENSG00000019582(gene)|ensembl:ENST00000009530(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001516"(prostaglandin biosynthetic process)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001961"(positive regulation of cytokine-mediated signaling pathway)|go:"GO:0002286"(T cell activation involved in immune response)|go:"GO:0002606"(positive regulation of dendritic cell antigen processing and presentation)|go:"GO:0002792"(negative regulation of peptide secretion)|go:"GO:0002830"(positive regulation of type 2 immune response)|go:"GO:0002906"(negative regulation of mature B cell apoptotic process)|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005770"(late endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005773"(vacuole)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0008283"(cell population proliferation)|go:"GO:0009986"(cell surface)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016064"(immunoglobulin mediated immune response)|go:"GO:0019882"(antigen processing and presentation)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0019883"(antigen processing and presentation of endogenous antigen)|go:"GO:0019886"(antigen processing and presentation of exogenous peptide antigen via MHC class II)|go:"GO:0019955"(cytokine binding)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0031394"(positive regulation of prostaglandin biosynthetic process)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0034341"(response to interferon-gamma)|go:"GO:0035691"(macrophage migration inhibitory factor signaling pathway)|go:"GO:0035692"(macrophage migration inhibitory factor receptor complex)|go:"GO:0035693"(NOS2-CD74 complex)|go:"GO:0035718"(macrophage migration inhibitory factor binding)|go:"GO:0042289"(MHC class II protein binding)|go:"GO:0042609"(CD4 receptor binding)|go:"GO:0042613"(MHC class II protein complex)|go:"GO:0042658"(MHC class II protein binding, via antigen binding groove)|go:"GO:0042802"(identical protein binding)|go:"GO:0043030"(regulation of macrophage activation)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043518"(negative regulation of DNA damage response, signal transduction by p53 class mediator)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0045058"(T cell selection)|go:"GO:0045059"(positive thymic T cell selection)|go:"GO:0045060"(negative thymic T cell selection)|go:"GO:0045581"(negative regulation of T cell differentiation)|go:"GO:0045582"(positive regulation of T cell differentiation)|go:"GO:0045657"(positive regulation of monocyte differentiation)|go:"GO:0071556"(integral component of lumenal side of endoplasmic reticulum membrane)|go:"GO:0090023"(positive regulation of neutrophil chemotaxis)|go:"GO:1902166"(negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:2000343"("positive regulation of chemokine (C-X-C motif) ligand 2 production")|go:"GO:2000448"(positive regulation of macrophage migration inhibitory factor signaling pathway)|interpro:IPR000716(Thyroglobulin type-1)|interpro:IPR011988(MHC class II-associated invariant chain, trimerisation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|interpro:IPR015386(MHC class II-associated invariant chain/CLIP, MHC II-interacting)|interpro:IPR022339|interpro:IPR036613|go:"GO:0046597"(negative regulation of viral entry into host cell)|interpro:IPR036857|interpro:IPR043530|mint:P04233|rcsb pdb:1A6A|rcsb pdb:1ICF|rcsb pdb:1IIE|rcsb pdb:1L3H|rcsb pdb:1MUJ|rcsb pdb:3PDO|rcsb pdb:3PGC|rcsb pdb:3PGD|go:"GO:0046598"(positive regulation of viral entry into host cell)|rcsb pdb:3QXA|go:"GO:0048146"(positive regulation of fibroblast proliferation)|rcsb pdb:3QXD|rcsb pdb:4AEN|rcsb pdb:4AH2|rcsb pdb:4X5W|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|rcsb pdb:5KSU|rcsb pdb:5KSV|go:"GO:0050821"(protein stabilization)|reactome:R-HSA-202733|reactome:R-HSA-2132295|go:"GO:0050998"(nitric-oxide synthase binding)|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0060907"(positive regulation of macrophage cytokine production)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070206"(protein trimerization)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)	refseq:NP_003339.1|dip:DIP-29829N|ensembl:ENSG00000177889(gene)|ensembl:ENST00000318066(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000729"(DNA double-strand break processing)|go:"GO:0001650"(fibrillar center)|go:"GO:0003723"(RNA binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006282"(regulation of DNA repair)|go:"GO:0006301"(postreplication repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016574"(histone ubiquitination)|go:"GO:0031058"(positive regulation of histone modification)|go:"GO:0031372"(UBC13-MMS2 complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033182"(regulation of histone ubiquitination)|go:"GO:0035370"(UBC13-UEV1A complex)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0061631"(ubiquitin conjugating enzyme activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070534"(protein K63-linked ubiquitination)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|interpro:IPR023313|rcsb pdb:1J7D|rcsb pdb:2C2V|rcsb pdb:3HCT|rcsb pdb:3HCU|rcsb pdb:3VON|rcsb pdb:3W31|rcsb pdb:4DHI|rcsb pdb:4DHJ|rcsb pdb:4DHZ|rcsb pdb:4IP3|rcsb pdb:4NR3|rcsb pdb:4NRG|rcsb pdb:4NRI|rcsb pdb:4ONL|rcsb pdb:4ONM|rcsb pdb:4ONN|rcsb pdb:4ORH|rcsb pdb:4TKP|rcsb pdb:4WHV|rcsb pdb:5AIT|rcsb pdb:5AIU|rcsb pdb:5EYA|rcsb pdb:5H7S|rcsb pdb:5VNZ|rcsb pdb:5VO0|rcsb pdb:5YWR|rcsb pdb:6D6I|rcsb pdb:6JKY|rcsb pdb:6KFP|rcsb pdb:6KG6|rcsb pdb:6KL4|rcsb pdb:6LP2|rcsb pdb:6P5B|rcsb pdb:6S53|reactome:R-HSA-168927|reactome:R-HSA-202424|reactome:R-HSA-2871837|reactome:R-HSA-445989|reactome:R-HSA-450302|reactome:R-HSA-450321|reactome:R-HSA-5607764|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-5696395|reactome:R-HSA-69473|reactome:R-HSA-8866654|reactome:R-HSA-9020702|reactome:R-HSA-937039|reactome:R-HSA-937041|reactome:R-HSA-9646399|reactome:R-HSA-975110|reactome:R-HSA-975144|reactome:R-HSA-983168|rcsb pdb:6ULH|rcsb pdb:6UMP|rcsb pdb:6UMS|rcsb pdb:7BBD|rcsb pdb:7BBF|rcsb pdb:7BXG|reactome:R-HSA-1169408|reactome:R-HSA-168638	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S3|resulting-ptm:P04233 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:jP1UH09kpXY45O7Qr5OdAfDDIXY9606	rogid:dqdszHlq5FLPHC6UWX6uvkC6Yz89606	intact-crc:3D266AAE43529A3B|rigid:6sNyd9/yZm+Uys4Ichfp5ZxrdMU	false	-	his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q62925	uniprotkb:Q13404	intact:EBI-636664	intact:EBI-1050671|uniprotkb:Q13403|uniprotkb:Q13532|uniprotkb:Q96H34|uniprotkb:Q9GZT0|uniprotkb:Q9GZW1|uniprotkb:Q9H4J3|uniprotkb:Q9H4J4|uniprotkb:Q9UKL1|uniprotkb:Q9UM48|uniprotkb:Q9UM49|uniprotkb:Q9UM50|uniprotkb:Q5TGE3|uniprotkb:E1P629|uniprotkb:Q5TGE0|ensembl:ENSP00000360739	psi-mi:m3k1_rat(display_long)|uniprotkb:MAPK/ERK kinase kinase 1(gene name synonym)|uniprotkb:Map3k1(gene name)|psi-mi:Map3k1(display_short)|uniprotkb:Mekk(gene name synonym)|uniprotkb:Mekk1(gene name synonym)	psi-mi:ub2v1_human(display_long)|uniprotkb:CROC-1(gene name synonym)|uniprotkb:TRAF6-regulated IKK activator 1 beta Uev1A(gene name synonym)|uniprotkb:P/OKcl.19(orf name)|uniprotkb:UBE2V1(gene name)|psi-mi:UBE2V1(display_short)|uniprotkb:CROC1(gene name synonym)|uniprotkb:UBE2V(gene name synonym)|uniprotkb:UEV1(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9971535|imex:IM-22822-75	author-confidence:Z-score = 11.27	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:620966|refseq:NP_446339.1|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR007527(Zinc finger, SWIM-type)|go:"GO:0000165"(MAPK cascade)|interpro:IPR016024(Armadillo-type fold)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0002011"(morphogenesis of an epithelial sheet)|go:"GO:0003382"(epithelial cell morphogenesis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004706"(JUN kinase kinase kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007254"(JNK cascade)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008432"(JUN kinase binding)|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0016020"(membrane)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0031434"(mitogen-activated protein kinase kinase binding)|go:"GO:0031941"(filamentous actin)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0042060"(wound healing)|go:"GO:0043010"(camera-type eye development)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046625"(sphingolipid binding)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050434"(positive regulation of viral transcription)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0061029"(eyelid development in camera-type eye)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|reactome:R-RNO-166058|reactome:R-RNO-2871796|reactome:R-RNO-975138|reactome:R-RNO-975871|interpro:IPR011989(Armadillo-like helical)|mint:Q62925	refseq:NP_001027459.1|refseq:NP_068823.2|refseq:NP_071887.1|refseq:NP_954595.1|refseq:NP_954673.1|refseq:NP_001244322.1|refseq:NP_001244323.1|refseq:NP_001244325.1|ensembl:ENSG00000244687(gene)|ensembl:ENST00000371674(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006282"(regulation of DNA repair)|go:"GO:0006301"(postreplication repair)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0030154"(cell differentiation)|go:"GO:0031371"(ubiquitin conjugating enzyme complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035370"(UBC13-UEV1A complex)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070534"(protein K63-linked ubiquitination)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|rcsb pdb:2A4D|rcsb pdb:2C2V|rcsb pdb:2HLW|rcsb pdb:6D6I|reactome:R-HSA-168638|reactome:R-HSA-168927|reactome:R-HSA-202424|reactome:R-HSA-2871837|reactome:R-HSA-445989|reactome:R-HSA-450302|reactome:R-HSA-450321|reactome:R-HSA-5607764|reactome:R-HSA-9020702|reactome:R-HSA-937039|reactome:R-HSA-937041|reactome:R-HSA-9646399|reactome:R-HSA-975110|reactome:R-HSA-975144|reactome:R-HSA-983168|dip:DIP-41911N	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S3|resulting-ptm:O94888 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:EwhjYjowkZIAt4UyPcZBUtf9uak10116	rogid:x95N7Dj2KIqu5gySX59xLmfthUg9606	intact-crc:FB35C37416571B4F|rigid:wvNrh4/qYhEYI9JT2MI0sR/05bQ	false	sufficient binding region:433-481(IPR013083)	his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q62925	uniprotkb:P22314	intact:EBI-636664	intact:EBI-709688|uniprotkb:Q96E13|uniprotkb:Q5JRR8|ensembl:ENSP00000338413|ensembl:ENSP00000366568	psi-mi:m3k1_rat(display_long)|uniprotkb:MAPK/ERK kinase kinase 1(gene name synonym)|uniprotkb:Map3k1(gene name)|psi-mi:Map3k1(display_short)|uniprotkb:Mekk(gene name synonym)|uniprotkb:Mekk1(gene name synonym)	psi-mi:uba1_human(display_long)|uniprotkb:Ubiquitin-activating enzyme E1(gene name synonym)|uniprotkb:Protein A1S9(gene name synonym)|uniprotkb:UBA1(gene name)|psi-mi:UBA1(display_short)|uniprotkb:A1S9T(gene name synonym)|uniprotkb:UBE1(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9971535|imex:IM-22822-75	author-confidence:Z-score = 11.27	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:620966|refseq:NP_446339.1|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR007527(Zinc finger, SWIM-type)|go:"GO:0000165"(MAPK cascade)|interpro:IPR016024(Armadillo-type fold)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0002011"(morphogenesis of an epithelial sheet)|go:"GO:0003382"(epithelial cell morphogenesis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004706"(JUN kinase kinase kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007254"(JNK cascade)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008432"(JUN kinase binding)|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0016020"(membrane)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0031434"(mitogen-activated protein kinase kinase binding)|go:"GO:0031941"(filamentous actin)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0042060"(wound healing)|go:"GO:0043010"(camera-type eye development)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046625"(sphingolipid binding)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050434"(positive regulation of viral transcription)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0061029"(eyelid development in camera-type eye)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|reactome:R-RNO-166058|reactome:R-RNO-2871796|reactome:R-RNO-975138|reactome:R-RNO-975871|interpro:IPR011989(Armadillo-like helical)|mint:Q62925	refseq:NP_003325.2|refseq:NP_695012.1|refseq:XP_016885269.1|refseq:XP_016885270.1|dip:DIP-33686N|ensembl:ENSG00000130985(gene)|ensembl:ENST00000335972(transcript)|ensembl:ENST00000377351(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0004839"(ubiquitin activating enzyme activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0032446"(protein modification by small protein conjugation)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000011(Ubiquitin-activating enzyme, E1)|interpro:IPR000594(UBA/THIF-type NAD/FAD binding fold)|interpro:IPR018074|interpro:IPR018075|interpro:IPR018965|interpro:IPR019572|interpro:IPR032418|interpro:IPR032420|interpro:IPR033127|interpro:IPR035985|interpro:IPR038252|interpro:IPR042063|interpro:IPR042302|interpro:IPR042449|mint:P22314|rcsb pdb:4P22|rcsb pdb:6DC6|reactome:R-HSA-8866652|reactome:R-HSA-983168	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S3|resulting-ptm:O94888 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:EwhjYjowkZIAt4UyPcZBUtf9uak10116	rogid:q+vEeA0XLST0Zz173bmEt0dNbDE9606	intact-crc:FB35C37416571B4F|rigid:wvNrh4/qYhEYI9JT2MI0sR/05bQ	false	sufficient binding region:433-481(IPR013083)	his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q62925	uniprotkb:P61088	intact:EBI-636664	intact:EBI-1052908|uniprotkb:Q16781|uniprotkb:Q53Y81|ensembl:ENSP00000316176	psi-mi:m3k1_rat(display_long)|uniprotkb:MAPK/ERK kinase kinase 1(gene name synonym)|uniprotkb:Map3k1(gene name)|psi-mi:Map3k1(display_short)|uniprotkb:Mekk(gene name synonym)|uniprotkb:Mekk1(gene name synonym)	psi-mi:ube2n_human(display_long)|uniprotkb:Ubiquitin-protein ligase N(gene name synonym)|uniprotkb:Ubiquitin carrier protein N(gene name synonym)|uniprotkb:Ubc13(gene name synonym)|uniprotkb:Bendless-like ubiquitin-conjugating enzyme(gene name synonym)|uniprotkb:UBE2N(gene name)|psi-mi:UBE2N(display_short)|uniprotkb:BLU(gene name synonym)|uniprotkb:UbcH13(gene name synonym)|uniprotkb:E2 ubiquitin-conjugating enzyme N(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9971535|imex:IM-22822-75	author-confidence:Z-score = 11.27	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:620966|refseq:NP_446339.1|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR007527(Zinc finger, SWIM-type)|go:"GO:0000165"(MAPK cascade)|interpro:IPR016024(Armadillo-type fold)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0002011"(morphogenesis of an epithelial sheet)|go:"GO:0003382"(epithelial cell morphogenesis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004706"(JUN kinase kinase kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007254"(JNK cascade)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008432"(JUN kinase binding)|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0016020"(membrane)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0031434"(mitogen-activated protein kinase kinase binding)|go:"GO:0031941"(filamentous actin)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0042060"(wound healing)|go:"GO:0043010"(camera-type eye development)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046625"(sphingolipid binding)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050434"(positive regulation of viral transcription)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0061029"(eyelid development in camera-type eye)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|reactome:R-RNO-166058|reactome:R-RNO-2871796|reactome:R-RNO-975138|reactome:R-RNO-975871|interpro:IPR011989(Armadillo-like helical)|mint:Q62925	refseq:NP_003339.1|dip:DIP-29829N|ensembl:ENSG00000177889(gene)|ensembl:ENST00000318066(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000729"(DNA double-strand break processing)|go:"GO:0001650"(fibrillar center)|go:"GO:0003723"(RNA binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006282"(regulation of DNA repair)|go:"GO:0006301"(postreplication repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016574"(histone ubiquitination)|go:"GO:0031058"(positive regulation of histone modification)|go:"GO:0031372"(UBC13-MMS2 complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033182"(regulation of histone ubiquitination)|go:"GO:0035370"(UBC13-UEV1A complex)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0061631"(ubiquitin conjugating enzyme activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070534"(protein K63-linked ubiquitination)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|interpro:IPR023313|rcsb pdb:1J7D|rcsb pdb:2C2V|rcsb pdb:3HCT|rcsb pdb:3HCU|rcsb pdb:3VON|rcsb pdb:3W31|rcsb pdb:4DHI|rcsb pdb:4DHJ|rcsb pdb:4DHZ|rcsb pdb:4IP3|rcsb pdb:4NR3|rcsb pdb:4NRG|rcsb pdb:4NRI|rcsb pdb:4ONL|rcsb pdb:4ONM|rcsb pdb:4ONN|rcsb pdb:4ORH|rcsb pdb:4TKP|rcsb pdb:4WHV|rcsb pdb:5AIT|rcsb pdb:5AIU|rcsb pdb:5EYA|rcsb pdb:5H7S|rcsb pdb:5VNZ|rcsb pdb:5VO0|rcsb pdb:5YWR|rcsb pdb:6D6I|rcsb pdb:6JKY|rcsb pdb:6KFP|rcsb pdb:6KG6|rcsb pdb:6KL4|rcsb pdb:6LP2|rcsb pdb:6P5B|rcsb pdb:6S53|reactome:R-HSA-168927|reactome:R-HSA-202424|reactome:R-HSA-2871837|reactome:R-HSA-445989|reactome:R-HSA-450302|reactome:R-HSA-450321|reactome:R-HSA-5607764|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-5696395|reactome:R-HSA-69473|reactome:R-HSA-8866654|reactome:R-HSA-9020702|reactome:R-HSA-937039|reactome:R-HSA-937041|reactome:R-HSA-9646399|reactome:R-HSA-975110|reactome:R-HSA-975144|reactome:R-HSA-983168|rcsb pdb:6ULH|rcsb pdb:6UMP|rcsb pdb:6UMS|rcsb pdb:7BBD|rcsb pdb:7BBF|rcsb pdb:7BXG|reactome:R-HSA-1169408|reactome:R-HSA-168638	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S3|resulting-ptm:O94888 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:EwhjYjowkZIAt4UyPcZBUtf9uak10116	rogid:dqdszHlq5FLPHC6UWX6uvkC6Yz89606	intact-crc:FB35C37416571B4F|rigid:wvNrh4/qYhEYI9JT2MI0sR/05bQ	false	sufficient binding region:433-481(IPR013083)	his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q62925	uniprotkb:O94888	intact:EBI-636664	intact:EBI-1993627|uniprotkb:D3DXB3|uniprotkb:Q6ZP77|uniprotkb:Q86X20|uniprotkb:Q8N327|ensembl:ENSP00000296328	psi-mi:m3k1_rat(display_long)|uniprotkb:MAPK/ERK kinase kinase 1(gene name synonym)|uniprotkb:Map3k1(gene name)|psi-mi:Map3k1(display_short)|uniprotkb:Mekk(gene name synonym)|uniprotkb:Mekk1(gene name synonym)	psi-mi:ubxn7_human(display_long)|uniprotkb:UBXD7(gene name synonym)|uniprotkb:UBXN7(gene name)|psi-mi:UBXN7(display_short)|uniprotkb:KIAA0794(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9971535|imex:IM-22822-75	author-confidence:Z-score = 11.27	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:620966|refseq:NP_446339.1|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR007527(Zinc finger, SWIM-type)|go:"GO:0000165"(MAPK cascade)|interpro:IPR016024(Armadillo-type fold)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0002011"(morphogenesis of an epithelial sheet)|go:"GO:0003382"(epithelial cell morphogenesis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004706"(JUN kinase kinase kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007254"(JNK cascade)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008432"(JUN kinase binding)|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0016020"(membrane)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0031434"(mitogen-activated protein kinase kinase binding)|go:"GO:0031941"(filamentous actin)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0042060"(wound healing)|go:"GO:0043010"(camera-type eye development)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046625"(sphingolipid binding)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050434"(positive regulation of viral transcription)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0061029"(eyelid development in camera-type eye)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|reactome:R-RNO-166058|reactome:R-RNO-2871796|reactome:R-RNO-975138|reactome:R-RNO-975871|interpro:IPR011989(Armadillo-like helical)|mint:Q62925	refseq:NP_056377.1|dip:DIP-47029N|ensembl:ENSG00000163960(gene)|ensembl:ENST00000296328(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0008134"(transcription factor binding)|go:"GO:0016604"(nuclear body)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0034098"(VCP-NPL4-UFD1 AAA ATPase complex)|go:"GO:0043130"(ubiquitin binding)|interpro:IPR001012(UBX)|interpro:IPR006577(UAS)|interpro:IPR009060(UBA-like)|interpro:IPR017346(Uncharacterised conserved protein UCP037991, UAS, UBX)|interpro:IPR029071|interpro:IPR036249|rcsb pdb:1WJ4|rcsb pdb:2DAL|rcsb pdb:2DLX|rcsb pdb:5X3P|rcsb pdb:5X4L|reactome:R-HSA-8951664	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S3|resulting-ptm:O94888 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:EwhjYjowkZIAt4UyPcZBUtf9uak10116	rogid:TyFBtC4hXtG1WTSl8wLgPIoDxpg9606	intact-crc:FB35C37416571B4F|rigid:wvNrh4/qYhEYI9JT2MI0sR/05bQ	false	sufficient binding region:433-481(IPR013083)	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P25686	uniprotkb:Q62925	intact:EBI-6166532|ensembl:ENSP00000338019|uniprotkb:A8K9P6|uniprotkb:Q8IUK1|uniprotkb:Q8IUK2|uniprotkb:Q96F52|uniprotkb:Q53QD7	intact:EBI-636664	psi-mi:dnjb2_human(display_long)|uniprotkb:DNAJB2(gene name)|psi-mi:DNAJB2(display_short)|uniprotkb:HSJ1(gene name synonym)|uniprotkb:HSPF3(gene name synonym)|uniprotkb:Heat shock 40 kDa protein 3(gene name synonym)|uniprotkb:Heat shock protein J1(gene name synonym)	psi-mi:m3k1_rat(display_long)|uniprotkb:MAPK/ERK kinase kinase 1(gene name synonym)|uniprotkb:Map3k1(gene name)|psi-mi:Map3k1(display_short)|uniprotkb:Mekk(gene name synonym)|uniprotkb:Mekk1(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9971610|imex:IM-22822-78	author-confidence:Z-score = 9.96	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000135924(gene)|ensembl:ENST00000336576(transcript)|go:"GO:0001671"(ATPase activator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0016234"(inclusion body)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0061077"(chaperone-mediated protein folding)|go:"GO:0070050"(neuron cellular homeostasis)|go:"GO:0070628"(proteasome binding)|go:"GO:0090084"(negative regulation of inclusion body assembly)|go:"GO:0090086"(negative regulation of protein deubiquitination)|go:"GO:0098554"(cytoplasmic side of endoplasmic reticulum membrane)|go:"GO:0140036"(ubiquitin-dependent protein binding)|go:"GO:1903644"(regulation of chaperone-mediated protein folding)|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|interpro:IPR003903(Ubiquitin interacting motif)|interpro:IPR018253|interpro:IPR036869|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0031227"(intrinsic component of endoplasmic reticulum membrane)|go:"GO:0031396"(regulation of protein ubiquitination)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0031593"(polyubiquitin modification-dependent protein binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032781"(positive regulation of ATP-dependent activity)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0042026"(protein refolding)|go:"GO:0042406"(extrinsic component of endoplasmic reticulum membrane)|go:"GO:0043130"(ubiquitin binding)|mint:P25686|rcsb pdb:2LGW|interpro:IPR043183|refseq:NP_001034639.1|refseq:NP_006727.2|dip:DIP-29051N	rgd:620966|refseq:NP_446339.1|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR007527(Zinc finger, SWIM-type)|go:"GO:0000165"(MAPK cascade)|interpro:IPR016024(Armadillo-type fold)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0002011"(morphogenesis of an epithelial sheet)|go:"GO:0003382"(epithelial cell morphogenesis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004706"(JUN kinase kinase kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007254"(JNK cascade)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008432"(JUN kinase binding)|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0016020"(membrane)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0031434"(mitogen-activated protein kinase kinase binding)|go:"GO:0031941"(filamentous actin)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0042060"(wound healing)|go:"GO:0043010"(camera-type eye development)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046625"(sphingolipid binding)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050434"(positive regulation of viral transcription)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0061029"(eyelid development in camera-type eye)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|reactome:R-RNO-166058|reactome:R-RNO-2871796|reactome:R-RNO-975138|reactome:R-RNO-975871|interpro:IPR011989(Armadillo-like helical)|mint:Q62925	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S3|resulting-ptm:P25686 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:BpmS2Mrk3FLzXLC0o3vIvSVPd3c9606	rogid:EwhjYjowkZIAt4UyPcZBUtf9uak10116	intact-crc:B643A8DF77F598D7|rigid:C+8s7JiOdqiE8MWkIB3OvMsxqzc	false	-	sufficient binding region:433-481(IPR013083)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P25686	uniprotkb:Q13404	intact:EBI-6166532|ensembl:ENSP00000338019|uniprotkb:A8K9P6|uniprotkb:Q8IUK1|uniprotkb:Q8IUK2|uniprotkb:Q96F52|uniprotkb:Q53QD7	intact:EBI-1050671|uniprotkb:Q13403|uniprotkb:Q13532|uniprotkb:Q96H34|uniprotkb:Q9GZT0|uniprotkb:Q9GZW1|uniprotkb:Q9H4J3|uniprotkb:Q9H4J4|uniprotkb:Q9UKL1|uniprotkb:Q9UM48|uniprotkb:Q9UM49|uniprotkb:Q9UM50|uniprotkb:Q5TGE3|uniprotkb:E1P629|uniprotkb:Q5TGE0|ensembl:ENSP00000360739	psi-mi:dnjb2_human(display_long)|uniprotkb:DNAJB2(gene name)|psi-mi:DNAJB2(display_short)|uniprotkb:HSJ1(gene name synonym)|uniprotkb:HSPF3(gene name synonym)|uniprotkb:Heat shock 40 kDa protein 3(gene name synonym)|uniprotkb:Heat shock protein J1(gene name synonym)	psi-mi:ub2v1_human(display_long)|uniprotkb:CROC-1(gene name synonym)|uniprotkb:TRAF6-regulated IKK activator 1 beta Uev1A(gene name synonym)|uniprotkb:P/OKcl.19(orf name)|uniprotkb:UBE2V1(gene name)|psi-mi:UBE2V1(display_short)|uniprotkb:CROC1(gene name synonym)|uniprotkb:UBE2V(gene name synonym)|uniprotkb:UEV1(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9971610|imex:IM-22822-78	author-confidence:Z-score = 9.96	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000135924(gene)|ensembl:ENST00000336576(transcript)|go:"GO:0001671"(ATPase activator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0016234"(inclusion body)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0061077"(chaperone-mediated protein folding)|go:"GO:0070050"(neuron cellular homeostasis)|go:"GO:0070628"(proteasome binding)|go:"GO:0090084"(negative regulation of inclusion body assembly)|go:"GO:0090086"(negative regulation of protein deubiquitination)|go:"GO:0098554"(cytoplasmic side of endoplasmic reticulum membrane)|go:"GO:0140036"(ubiquitin-dependent protein binding)|go:"GO:1903644"(regulation of chaperone-mediated protein folding)|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|interpro:IPR003903(Ubiquitin interacting motif)|interpro:IPR018253|interpro:IPR036869|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0031227"(intrinsic component of endoplasmic reticulum membrane)|go:"GO:0031396"(regulation of protein ubiquitination)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0031593"(polyubiquitin modification-dependent protein binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032781"(positive regulation of ATP-dependent activity)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0042026"(protein refolding)|go:"GO:0042406"(extrinsic component of endoplasmic reticulum membrane)|go:"GO:0043130"(ubiquitin binding)|mint:P25686|rcsb pdb:2LGW|interpro:IPR043183|refseq:NP_001034639.1|refseq:NP_006727.2|dip:DIP-29051N	refseq:NP_001027459.1|refseq:NP_068823.2|refseq:NP_071887.1|refseq:NP_954595.1|refseq:NP_954673.1|refseq:NP_001244322.1|refseq:NP_001244323.1|refseq:NP_001244325.1|ensembl:ENSG00000244687(gene)|ensembl:ENST00000371674(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006282"(regulation of DNA repair)|go:"GO:0006301"(postreplication repair)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0030154"(cell differentiation)|go:"GO:0031371"(ubiquitin conjugating enzyme complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035370"(UBC13-UEV1A complex)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070534"(protein K63-linked ubiquitination)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|rcsb pdb:2A4D|rcsb pdb:2C2V|rcsb pdb:2HLW|rcsb pdb:6D6I|reactome:R-HSA-168638|reactome:R-HSA-168927|reactome:R-HSA-202424|reactome:R-HSA-2871837|reactome:R-HSA-445989|reactome:R-HSA-450302|reactome:R-HSA-450321|reactome:R-HSA-5607764|reactome:R-HSA-9020702|reactome:R-HSA-937039|reactome:R-HSA-937041|reactome:R-HSA-9646399|reactome:R-HSA-975110|reactome:R-HSA-975144|reactome:R-HSA-983168|dip:DIP-41911N	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S3|resulting-ptm:P25686 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:BpmS2Mrk3FLzXLC0o3vIvSVPd3c9606	rogid:x95N7Dj2KIqu5gySX59xLmfthUg9606	intact-crc:B643A8DF77F598D7|rigid:C+8s7JiOdqiE8MWkIB3OvMsxqzc	false	-	his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P25686	uniprotkb:P22314	intact:EBI-6166532|ensembl:ENSP00000338019|uniprotkb:A8K9P6|uniprotkb:Q8IUK1|uniprotkb:Q8IUK2|uniprotkb:Q96F52|uniprotkb:Q53QD7	intact:EBI-709688|uniprotkb:Q96E13|uniprotkb:Q5JRR8|ensembl:ENSP00000338413|ensembl:ENSP00000366568	psi-mi:dnjb2_human(display_long)|uniprotkb:DNAJB2(gene name)|psi-mi:DNAJB2(display_short)|uniprotkb:HSJ1(gene name synonym)|uniprotkb:HSPF3(gene name synonym)|uniprotkb:Heat shock 40 kDa protein 3(gene name synonym)|uniprotkb:Heat shock protein J1(gene name synonym)	psi-mi:uba1_human(display_long)|uniprotkb:Ubiquitin-activating enzyme E1(gene name synonym)|uniprotkb:Protein A1S9(gene name synonym)|uniprotkb:UBA1(gene name)|psi-mi:UBA1(display_short)|uniprotkb:A1S9T(gene name synonym)|uniprotkb:UBE1(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9971610|imex:IM-22822-78	author-confidence:Z-score = 9.96	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000135924(gene)|ensembl:ENST00000336576(transcript)|go:"GO:0001671"(ATPase activator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0016234"(inclusion body)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0061077"(chaperone-mediated protein folding)|go:"GO:0070050"(neuron cellular homeostasis)|go:"GO:0070628"(proteasome binding)|go:"GO:0090084"(negative regulation of inclusion body assembly)|go:"GO:0090086"(negative regulation of protein deubiquitination)|go:"GO:0098554"(cytoplasmic side of endoplasmic reticulum membrane)|go:"GO:0140036"(ubiquitin-dependent protein binding)|go:"GO:1903644"(regulation of chaperone-mediated protein folding)|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|interpro:IPR003903(Ubiquitin interacting motif)|interpro:IPR018253|interpro:IPR036869|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0031227"(intrinsic component of endoplasmic reticulum membrane)|go:"GO:0031396"(regulation of protein ubiquitination)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0031593"(polyubiquitin modification-dependent protein binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032781"(positive regulation of ATP-dependent activity)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0042026"(protein refolding)|go:"GO:0042406"(extrinsic component of endoplasmic reticulum membrane)|go:"GO:0043130"(ubiquitin binding)|mint:P25686|rcsb pdb:2LGW|interpro:IPR043183|refseq:NP_001034639.1|refseq:NP_006727.2|dip:DIP-29051N	refseq:NP_003325.2|refseq:NP_695012.1|refseq:XP_016885269.1|refseq:XP_016885270.1|dip:DIP-33686N|ensembl:ENSG00000130985(gene)|ensembl:ENST00000335972(transcript)|ensembl:ENST00000377351(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0004839"(ubiquitin activating enzyme activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0032446"(protein modification by small protein conjugation)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000011(Ubiquitin-activating enzyme, E1)|interpro:IPR000594(UBA/THIF-type NAD/FAD binding fold)|interpro:IPR018074|interpro:IPR018075|interpro:IPR018965|interpro:IPR019572|interpro:IPR032418|interpro:IPR032420|interpro:IPR033127|interpro:IPR035985|interpro:IPR038252|interpro:IPR042063|interpro:IPR042302|interpro:IPR042449|mint:P22314|rcsb pdb:4P22|rcsb pdb:6DC6|reactome:R-HSA-8866652|reactome:R-HSA-983168	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S3|resulting-ptm:P25686 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:BpmS2Mrk3FLzXLC0o3vIvSVPd3c9606	rogid:q+vEeA0XLST0Zz173bmEt0dNbDE9606	intact-crc:B643A8DF77F598D7|rigid:C+8s7JiOdqiE8MWkIB3OvMsxqzc	false	-	his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P25686	uniprotkb:P61088	intact:EBI-6166532|ensembl:ENSP00000338019|uniprotkb:A8K9P6|uniprotkb:Q8IUK1|uniprotkb:Q8IUK2|uniprotkb:Q96F52|uniprotkb:Q53QD7	intact:EBI-1052908|uniprotkb:Q16781|uniprotkb:Q53Y81|ensembl:ENSP00000316176	psi-mi:dnjb2_human(display_long)|uniprotkb:DNAJB2(gene name)|psi-mi:DNAJB2(display_short)|uniprotkb:HSJ1(gene name synonym)|uniprotkb:HSPF3(gene name synonym)|uniprotkb:Heat shock 40 kDa protein 3(gene name synonym)|uniprotkb:Heat shock protein J1(gene name synonym)	psi-mi:ube2n_human(display_long)|uniprotkb:Ubiquitin-protein ligase N(gene name synonym)|uniprotkb:Ubiquitin carrier protein N(gene name synonym)|uniprotkb:Ubc13(gene name synonym)|uniprotkb:Bendless-like ubiquitin-conjugating enzyme(gene name synonym)|uniprotkb:UBE2N(gene name)|psi-mi:UBE2N(display_short)|uniprotkb:BLU(gene name synonym)|uniprotkb:UbcH13(gene name synonym)|uniprotkb:E2 ubiquitin-conjugating enzyme N(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9971610|imex:IM-22822-78	author-confidence:Z-score = 9.96	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000135924(gene)|ensembl:ENST00000336576(transcript)|go:"GO:0001671"(ATPase activator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0016234"(inclusion body)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0061077"(chaperone-mediated protein folding)|go:"GO:0070050"(neuron cellular homeostasis)|go:"GO:0070628"(proteasome binding)|go:"GO:0090084"(negative regulation of inclusion body assembly)|go:"GO:0090086"(negative regulation of protein deubiquitination)|go:"GO:0098554"(cytoplasmic side of endoplasmic reticulum membrane)|go:"GO:0140036"(ubiquitin-dependent protein binding)|go:"GO:1903644"(regulation of chaperone-mediated protein folding)|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|interpro:IPR003903(Ubiquitin interacting motif)|interpro:IPR018253|interpro:IPR036869|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0031227"(intrinsic component of endoplasmic reticulum membrane)|go:"GO:0031396"(regulation of protein ubiquitination)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0031593"(polyubiquitin modification-dependent protein binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032781"(positive regulation of ATP-dependent activity)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0042026"(protein refolding)|go:"GO:0042406"(extrinsic component of endoplasmic reticulum membrane)|go:"GO:0043130"(ubiquitin binding)|mint:P25686|rcsb pdb:2LGW|interpro:IPR043183|refseq:NP_001034639.1|refseq:NP_006727.2|dip:DIP-29051N	refseq:NP_003339.1|dip:DIP-29829N|ensembl:ENSG00000177889(gene)|ensembl:ENST00000318066(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000729"(DNA double-strand break processing)|go:"GO:0001650"(fibrillar center)|go:"GO:0003723"(RNA binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006282"(regulation of DNA repair)|go:"GO:0006301"(postreplication repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016574"(histone ubiquitination)|go:"GO:0031058"(positive regulation of histone modification)|go:"GO:0031372"(UBC13-MMS2 complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033182"(regulation of histone ubiquitination)|go:"GO:0035370"(UBC13-UEV1A complex)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0061631"(ubiquitin conjugating enzyme activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070534"(protein K63-linked ubiquitination)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|interpro:IPR023313|rcsb pdb:1J7D|rcsb pdb:2C2V|rcsb pdb:3HCT|rcsb pdb:3HCU|rcsb pdb:3VON|rcsb pdb:3W31|rcsb pdb:4DHI|rcsb pdb:4DHJ|rcsb pdb:4DHZ|rcsb pdb:4IP3|rcsb pdb:4NR3|rcsb pdb:4NRG|rcsb pdb:4NRI|rcsb pdb:4ONL|rcsb pdb:4ONM|rcsb pdb:4ONN|rcsb pdb:4ORH|rcsb pdb:4TKP|rcsb pdb:4WHV|rcsb pdb:5AIT|rcsb pdb:5AIU|rcsb pdb:5EYA|rcsb pdb:5H7S|rcsb pdb:5VNZ|rcsb pdb:5VO0|rcsb pdb:5YWR|rcsb pdb:6D6I|rcsb pdb:6JKY|rcsb pdb:6KFP|rcsb pdb:6KG6|rcsb pdb:6KL4|rcsb pdb:6LP2|rcsb pdb:6P5B|rcsb pdb:6S53|reactome:R-HSA-168927|reactome:R-HSA-202424|reactome:R-HSA-2871837|reactome:R-HSA-445989|reactome:R-HSA-450302|reactome:R-HSA-450321|reactome:R-HSA-5607764|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-5696395|reactome:R-HSA-69473|reactome:R-HSA-8866654|reactome:R-HSA-9020702|reactome:R-HSA-937039|reactome:R-HSA-937041|reactome:R-HSA-9646399|reactome:R-HSA-975110|reactome:R-HSA-975144|reactome:R-HSA-983168|rcsb pdb:6ULH|rcsb pdb:6UMP|rcsb pdb:6UMS|rcsb pdb:7BBD|rcsb pdb:7BBF|rcsb pdb:7BXG|reactome:R-HSA-1169408|reactome:R-HSA-168638	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S3|resulting-ptm:P25686 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:BpmS2Mrk3FLzXLC0o3vIvSVPd3c9606	rogid:dqdszHlq5FLPHC6UWX6uvkC6Yz89606	intact-crc:B643A8DF77F598D7|rigid:C+8s7JiOdqiE8MWkIB3OvMsxqzc	false	-	his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P21709	uniprotkb:Q62925	intact:EBI-968453|ensembl:ENSP00000275815|ensembl:ENSP00000494931|uniprotkb:B5A966|uniprotkb:B5A967|uniprotkb:Q15405|uniprotkb:A1L3V3	intact:EBI-636664	psi-mi:epha1_human(display_long)|uniprotkb:EPHA1(gene name)|psi-mi:EPHA1(display_short)|uniprotkb:EPH(gene name synonym)|uniprotkb:EPHT(gene name synonym)|uniprotkb:EPHT1(gene name synonym)|uniprotkb:Tyrosine-protein kinase receptor EPH(gene name synonym)|uniprotkb:EPH tyrosine kinase(gene name synonym)|uniprotkb:EPH tyrosine kinase 1(gene name synonym)|uniprotkb:Erythropoietin-producing hepatoma receptor(gene name synonym)	psi-mi:m3k1_rat(display_long)|uniprotkb:MAPK/ERK kinase kinase 1(gene name synonym)|uniprotkb:Map3k1(gene name)|psi-mi:Map3k1(display_short)|uniprotkb:Mekk(gene name synonym)|uniprotkb:Mekk1(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9971585|imex:IM-22822-77	author-confidence:Z-score = 8.76	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000146904(gene)|ensembl:ENSG00000284816(gene)|ensembl:ENST00000275815(transcript)|ensembl:ENST00000645847(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0001968"(fibronectin binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005005"(transmembrane-ephrin receptor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007411"(axon guidance)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0043005"(neuron projection)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043235"(receptor complex)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0090630"(activation of GTPase activity)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001090(Ephrin receptor, ligand binding)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001426(Receptor tyrosine kinase, class V, conserved site)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR008979(Galactose-binding like)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR016257(Tyrosine-protein kinase, ephrin receptor)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR027936|interpro:IPR034251|interpro:IPR036116|mint:P21709|rcsb pdb:2K1K|rcsb pdb:2K1L|rcsb pdb:3HIL|rcsb pdb:3KKA|reactome:R-HSA-2682334|reactome:R-HSA-2892247|reactome:R-HSA-3928663|reactome:R-HSA-3928665|refseq:NP_005223.4|dip:DIP-34886N	rgd:620966|refseq:NP_446339.1|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR007527(Zinc finger, SWIM-type)|go:"GO:0000165"(MAPK cascade)|interpro:IPR016024(Armadillo-type fold)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0002011"(morphogenesis of an epithelial sheet)|go:"GO:0003382"(epithelial cell morphogenesis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004706"(JUN kinase kinase kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007254"(JNK cascade)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008432"(JUN kinase binding)|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0016020"(membrane)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0031434"(mitogen-activated protein kinase kinase binding)|go:"GO:0031941"(filamentous actin)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0042060"(wound healing)|go:"GO:0043010"(camera-type eye development)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046625"(sphingolipid binding)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050434"(positive regulation of viral transcription)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0061029"(eyelid development in camera-type eye)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|reactome:R-RNO-166058|reactome:R-RNO-2871796|reactome:R-RNO-975138|reactome:R-RNO-975871|interpro:IPR011989(Armadillo-like helical)|mint:Q62925	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S3|resulting-ptm:P21709 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:TB6kRxNntZnW6eicjTb94922jDM9606	rogid:EwhjYjowkZIAt4UyPcZBUtf9uak10116	intact-crc:C64385392CCA3888|rigid:wJ5so0scGiGCjFfSCAL6tE+aa1A	false	-	sufficient binding region:433-481(IPR013083)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P21709	uniprotkb:Q13404	intact:EBI-968453|ensembl:ENSP00000275815|ensembl:ENSP00000494931|uniprotkb:B5A966|uniprotkb:B5A967|uniprotkb:Q15405|uniprotkb:A1L3V3	intact:EBI-1050671|uniprotkb:Q13403|uniprotkb:Q13532|uniprotkb:Q96H34|uniprotkb:Q9GZT0|uniprotkb:Q9GZW1|uniprotkb:Q9H4J3|uniprotkb:Q9H4J4|uniprotkb:Q9UKL1|uniprotkb:Q9UM48|uniprotkb:Q9UM49|uniprotkb:Q9UM50|uniprotkb:Q5TGE3|uniprotkb:E1P629|uniprotkb:Q5TGE0|ensembl:ENSP00000360739	psi-mi:epha1_human(display_long)|uniprotkb:EPHA1(gene name)|psi-mi:EPHA1(display_short)|uniprotkb:EPH(gene name synonym)|uniprotkb:EPHT(gene name synonym)|uniprotkb:EPHT1(gene name synonym)|uniprotkb:Tyrosine-protein kinase receptor EPH(gene name synonym)|uniprotkb:EPH tyrosine kinase(gene name synonym)|uniprotkb:EPH tyrosine kinase 1(gene name synonym)|uniprotkb:Erythropoietin-producing hepatoma receptor(gene name synonym)	psi-mi:ub2v1_human(display_long)|uniprotkb:CROC-1(gene name synonym)|uniprotkb:TRAF6-regulated IKK activator 1 beta Uev1A(gene name synonym)|uniprotkb:P/OKcl.19(orf name)|uniprotkb:UBE2V1(gene name)|psi-mi:UBE2V1(display_short)|uniprotkb:CROC1(gene name synonym)|uniprotkb:UBE2V(gene name synonym)|uniprotkb:UEV1(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9971585|imex:IM-22822-77	author-confidence:Z-score = 8.76	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000146904(gene)|ensembl:ENSG00000284816(gene)|ensembl:ENST00000275815(transcript)|ensembl:ENST00000645847(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0001968"(fibronectin binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005005"(transmembrane-ephrin receptor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007411"(axon guidance)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0043005"(neuron projection)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043235"(receptor complex)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0090630"(activation of GTPase activity)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001090(Ephrin receptor, ligand binding)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001426(Receptor tyrosine kinase, class V, conserved site)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR008979(Galactose-binding like)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR016257(Tyrosine-protein kinase, ephrin receptor)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR027936|interpro:IPR034251|interpro:IPR036116|mint:P21709|rcsb pdb:2K1K|rcsb pdb:2K1L|rcsb pdb:3HIL|rcsb pdb:3KKA|reactome:R-HSA-2682334|reactome:R-HSA-2892247|reactome:R-HSA-3928663|reactome:R-HSA-3928665|refseq:NP_005223.4|dip:DIP-34886N	refseq:NP_001027459.1|refseq:NP_068823.2|refseq:NP_071887.1|refseq:NP_954595.1|refseq:NP_954673.1|refseq:NP_001244322.1|refseq:NP_001244323.1|refseq:NP_001244325.1|ensembl:ENSG00000244687(gene)|ensembl:ENST00000371674(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006282"(regulation of DNA repair)|go:"GO:0006301"(postreplication repair)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0030154"(cell differentiation)|go:"GO:0031371"(ubiquitin conjugating enzyme complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035370"(UBC13-UEV1A complex)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070534"(protein K63-linked ubiquitination)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|rcsb pdb:2A4D|rcsb pdb:2C2V|rcsb pdb:2HLW|rcsb pdb:6D6I|reactome:R-HSA-168638|reactome:R-HSA-168927|reactome:R-HSA-202424|reactome:R-HSA-2871837|reactome:R-HSA-445989|reactome:R-HSA-450302|reactome:R-HSA-450321|reactome:R-HSA-5607764|reactome:R-HSA-9020702|reactome:R-HSA-937039|reactome:R-HSA-937041|reactome:R-HSA-9646399|reactome:R-HSA-975110|reactome:R-HSA-975144|reactome:R-HSA-983168|dip:DIP-41911N	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S3|resulting-ptm:P21709 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:TB6kRxNntZnW6eicjTb94922jDM9606	rogid:x95N7Dj2KIqu5gySX59xLmfthUg9606	intact-crc:C64385392CCA3888|rigid:wJ5so0scGiGCjFfSCAL6tE+aa1A	false	-	his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P21709	uniprotkb:P22314	intact:EBI-968453|ensembl:ENSP00000275815|ensembl:ENSP00000494931|uniprotkb:B5A966|uniprotkb:B5A967|uniprotkb:Q15405|uniprotkb:A1L3V3	intact:EBI-709688|uniprotkb:Q96E13|uniprotkb:Q5JRR8|ensembl:ENSP00000338413|ensembl:ENSP00000366568	psi-mi:epha1_human(display_long)|uniprotkb:EPHA1(gene name)|psi-mi:EPHA1(display_short)|uniprotkb:EPH(gene name synonym)|uniprotkb:EPHT(gene name synonym)|uniprotkb:EPHT1(gene name synonym)|uniprotkb:Tyrosine-protein kinase receptor EPH(gene name synonym)|uniprotkb:EPH tyrosine kinase(gene name synonym)|uniprotkb:EPH tyrosine kinase 1(gene name synonym)|uniprotkb:Erythropoietin-producing hepatoma receptor(gene name synonym)	psi-mi:uba1_human(display_long)|uniprotkb:Ubiquitin-activating enzyme E1(gene name synonym)|uniprotkb:Protein A1S9(gene name synonym)|uniprotkb:UBA1(gene name)|psi-mi:UBA1(display_short)|uniprotkb:A1S9T(gene name synonym)|uniprotkb:UBE1(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9971585|imex:IM-22822-77	author-confidence:Z-score = 8.76	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000146904(gene)|ensembl:ENSG00000284816(gene)|ensembl:ENST00000275815(transcript)|ensembl:ENST00000645847(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0001968"(fibronectin binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005005"(transmembrane-ephrin receptor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007411"(axon guidance)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0043005"(neuron projection)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043235"(receptor complex)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0090630"(activation of GTPase activity)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001090(Ephrin receptor, ligand binding)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001426(Receptor tyrosine kinase, class V, conserved site)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR008979(Galactose-binding like)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR016257(Tyrosine-protein kinase, ephrin receptor)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR027936|interpro:IPR034251|interpro:IPR036116|mint:P21709|rcsb pdb:2K1K|rcsb pdb:2K1L|rcsb pdb:3HIL|rcsb pdb:3KKA|reactome:R-HSA-2682334|reactome:R-HSA-2892247|reactome:R-HSA-3928663|reactome:R-HSA-3928665|refseq:NP_005223.4|dip:DIP-34886N	refseq:NP_003325.2|refseq:NP_695012.1|refseq:XP_016885269.1|refseq:XP_016885270.1|dip:DIP-33686N|ensembl:ENSG00000130985(gene)|ensembl:ENST00000335972(transcript)|ensembl:ENST00000377351(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0004839"(ubiquitin activating enzyme activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0032446"(protein modification by small protein conjugation)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000011(Ubiquitin-activating enzyme, E1)|interpro:IPR000594(UBA/THIF-type NAD/FAD binding fold)|interpro:IPR018074|interpro:IPR018075|interpro:IPR018965|interpro:IPR019572|interpro:IPR032418|interpro:IPR032420|interpro:IPR033127|interpro:IPR035985|interpro:IPR038252|interpro:IPR042063|interpro:IPR042302|interpro:IPR042449|mint:P22314|rcsb pdb:4P22|rcsb pdb:6DC6|reactome:R-HSA-8866652|reactome:R-HSA-983168	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S3|resulting-ptm:P21709 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:TB6kRxNntZnW6eicjTb94922jDM9606	rogid:q+vEeA0XLST0Zz173bmEt0dNbDE9606	intact-crc:C64385392CCA3888|rigid:wJ5so0scGiGCjFfSCAL6tE+aa1A	false	-	his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P21709	uniprotkb:P61088	intact:EBI-968453|ensembl:ENSP00000275815|ensembl:ENSP00000494931|uniprotkb:B5A966|uniprotkb:B5A967|uniprotkb:Q15405|uniprotkb:A1L3V3	intact:EBI-1052908|uniprotkb:Q16781|uniprotkb:Q53Y81|ensembl:ENSP00000316176	psi-mi:epha1_human(display_long)|uniprotkb:EPHA1(gene name)|psi-mi:EPHA1(display_short)|uniprotkb:EPH(gene name synonym)|uniprotkb:EPHT(gene name synonym)|uniprotkb:EPHT1(gene name synonym)|uniprotkb:Tyrosine-protein kinase receptor EPH(gene name synonym)|uniprotkb:EPH tyrosine kinase(gene name synonym)|uniprotkb:EPH tyrosine kinase 1(gene name synonym)|uniprotkb:Erythropoietin-producing hepatoma receptor(gene name synonym)	psi-mi:ube2n_human(display_long)|uniprotkb:Ubiquitin-protein ligase N(gene name synonym)|uniprotkb:Ubiquitin carrier protein N(gene name synonym)|uniprotkb:Ubc13(gene name synonym)|uniprotkb:Bendless-like ubiquitin-conjugating enzyme(gene name synonym)|uniprotkb:UBE2N(gene name)|psi-mi:UBE2N(display_short)|uniprotkb:BLU(gene name synonym)|uniprotkb:UbcH13(gene name synonym)|uniprotkb:E2 ubiquitin-conjugating enzyme N(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9971585|imex:IM-22822-77	author-confidence:Z-score = 8.76	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000146904(gene)|ensembl:ENSG00000284816(gene)|ensembl:ENST00000275815(transcript)|ensembl:ENST00000645847(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0001968"(fibronectin binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005005"(transmembrane-ephrin receptor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007411"(axon guidance)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0043005"(neuron projection)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043235"(receptor complex)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0090630"(activation of GTPase activity)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001090(Ephrin receptor, ligand binding)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001426(Receptor tyrosine kinase, class V, conserved site)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR008979(Galactose-binding like)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR016257(Tyrosine-protein kinase, ephrin receptor)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR027936|interpro:IPR034251|interpro:IPR036116|mint:P21709|rcsb pdb:2K1K|rcsb pdb:2K1L|rcsb pdb:3HIL|rcsb pdb:3KKA|reactome:R-HSA-2682334|reactome:R-HSA-2892247|reactome:R-HSA-3928663|reactome:R-HSA-3928665|refseq:NP_005223.4|dip:DIP-34886N	refseq:NP_003339.1|dip:DIP-29829N|ensembl:ENSG00000177889(gene)|ensembl:ENST00000318066(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000729"(DNA double-strand break processing)|go:"GO:0001650"(fibrillar center)|go:"GO:0003723"(RNA binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006282"(regulation of DNA repair)|go:"GO:0006301"(postreplication repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016574"(histone ubiquitination)|go:"GO:0031058"(positive regulation of histone modification)|go:"GO:0031372"(UBC13-MMS2 complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033182"(regulation of histone ubiquitination)|go:"GO:0035370"(UBC13-UEV1A complex)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0061631"(ubiquitin conjugating enzyme activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070534"(protein K63-linked ubiquitination)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|interpro:IPR023313|rcsb pdb:1J7D|rcsb pdb:2C2V|rcsb pdb:3HCT|rcsb pdb:3HCU|rcsb pdb:3VON|rcsb pdb:3W31|rcsb pdb:4DHI|rcsb pdb:4DHJ|rcsb pdb:4DHZ|rcsb pdb:4IP3|rcsb pdb:4NR3|rcsb pdb:4NRG|rcsb pdb:4NRI|rcsb pdb:4ONL|rcsb pdb:4ONM|rcsb pdb:4ONN|rcsb pdb:4ORH|rcsb pdb:4TKP|rcsb pdb:4WHV|rcsb pdb:5AIT|rcsb pdb:5AIU|rcsb pdb:5EYA|rcsb pdb:5H7S|rcsb pdb:5VNZ|rcsb pdb:5VO0|rcsb pdb:5YWR|rcsb pdb:6D6I|rcsb pdb:6JKY|rcsb pdb:6KFP|rcsb pdb:6KG6|rcsb pdb:6KL4|rcsb pdb:6LP2|rcsb pdb:6P5B|rcsb pdb:6S53|reactome:R-HSA-168927|reactome:R-HSA-202424|reactome:R-HSA-2871837|reactome:R-HSA-445989|reactome:R-HSA-450302|reactome:R-HSA-450321|reactome:R-HSA-5607764|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-5696395|reactome:R-HSA-69473|reactome:R-HSA-8866654|reactome:R-HSA-9020702|reactome:R-HSA-937039|reactome:R-HSA-937041|reactome:R-HSA-9646399|reactome:R-HSA-975110|reactome:R-HSA-975144|reactome:R-HSA-983168|rcsb pdb:6ULH|rcsb pdb:6UMP|rcsb pdb:6UMS|rcsb pdb:7BBD|rcsb pdb:7BBF|rcsb pdb:7BXG|reactome:R-HSA-1169408|reactome:R-HSA-168638	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S3|resulting-ptm:P21709 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:TB6kRxNntZnW6eicjTb94922jDM9606	rogid:dqdszHlq5FLPHC6UWX6uvkC6Yz89606	intact-crc:C64385392CCA3888|rigid:wJ5so0scGiGCjFfSCAL6tE+aa1A	false	-	his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q62925	uniprotkb:P54252-1	intact:EBI-636664	intact:EBI-946068|ensembl:ENSP00000437157	psi-mi:m3k1_rat(display_long)|uniprotkb:MAPK/ERK kinase kinase 1(gene name synonym)|uniprotkb:Map3k1(gene name)|psi-mi:Map3k1(display_short)|uniprotkb:Mekk(gene name synonym)|uniprotkb:Mekk1(gene name synonym)	psi-mi:p54252-1(display_long)|uniprotkb:ATXN3(gene name)|psi-mi:ATXN3(display_short)|uniprotkb:ATX3(gene name synonym)|uniprotkb:MJD(gene name synonym)|uniprotkb:MJD1(gene name synonym)|uniprotkb:SCA3(gene name synonym)|uniprotkb:Machado-Joseph disease protein 1(gene name synonym)|uniprotkb:Spinocerebellar ataxia type 3 protein(gene name synonym)|uniprotkb:MJD1a(isoform synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9971635|imex:IM-22822-79	author-confidence:Z-score = 6.53	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:620966|refseq:NP_446339.1|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR007527(Zinc finger, SWIM-type)|go:"GO:0000165"(MAPK cascade)|interpro:IPR016024(Armadillo-type fold)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0002011"(morphogenesis of an epithelial sheet)|go:"GO:0003382"(epithelial cell morphogenesis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004706"(JUN kinase kinase kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007254"(JNK cascade)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008432"(JUN kinase binding)|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0016020"(membrane)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0031434"(mitogen-activated protein kinase kinase binding)|go:"GO:0031941"(filamentous actin)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0042060"(wound healing)|go:"GO:0043010"(camera-type eye development)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046625"(sphingolipid binding)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050434"(positive regulation of viral transcription)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0061029"(eyelid development in camera-type eye)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|reactome:R-RNO-166058|reactome:R-RNO-2871796|reactome:R-RNO-975138|reactome:R-RNO-975871|interpro:IPR011989(Armadillo-like helical)|mint:Q62925	intact:EBI-946046(atx3_human)|ensembl:ENSG00000066427(gene)|ensembl:ENST00000532032(transcript)	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	isoform-comment:"Variant in position: 349:YELHVIFALHYSSFPL->Missing (in short isoform 1, due to a stop-gain single nucleotide polymorphism, has reduced half-life due to increased proteasomal degradation, has reduced solubility and increased tendency to form aggregates, increased localization to the nucleus)."	figure legend:Table S3|resulting-ptm:P54252 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2018/01/16	rogid:EwhjYjowkZIAt4UyPcZBUtf9uak10116	rogid:gFCEB9aqDG+N0hP6xAwf967TUKI9606	intact-crc:FB9345214677E3B9|rigid:Q2ZoTZo4+mgcPikAF5SFPhwB4mQ	false	sufficient binding region:433-481(IPR013083)	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q62925	uniprotkb:Q13404	intact:EBI-636664	intact:EBI-1050671|uniprotkb:Q13403|uniprotkb:Q13532|uniprotkb:Q96H34|uniprotkb:Q9GZT0|uniprotkb:Q9GZW1|uniprotkb:Q9H4J3|uniprotkb:Q9H4J4|uniprotkb:Q9UKL1|uniprotkb:Q9UM48|uniprotkb:Q9UM49|uniprotkb:Q9UM50|uniprotkb:Q5TGE3|uniprotkb:E1P629|uniprotkb:Q5TGE0|ensembl:ENSP00000360739	psi-mi:m3k1_rat(display_long)|uniprotkb:MAPK/ERK kinase kinase 1(gene name synonym)|uniprotkb:Map3k1(gene name)|psi-mi:Map3k1(display_short)|uniprotkb:Mekk(gene name synonym)|uniprotkb:Mekk1(gene name synonym)	psi-mi:ub2v1_human(display_long)|uniprotkb:CROC-1(gene name synonym)|uniprotkb:TRAF6-regulated IKK activator 1 beta Uev1A(gene name synonym)|uniprotkb:P/OKcl.19(orf name)|uniprotkb:UBE2V1(gene name)|psi-mi:UBE2V1(display_short)|uniprotkb:CROC1(gene name synonym)|uniprotkb:UBE2V(gene name synonym)|uniprotkb:UEV1(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9971635|imex:IM-22822-79	author-confidence:Z-score = 6.53	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:620966|refseq:NP_446339.1|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR007527(Zinc finger, SWIM-type)|go:"GO:0000165"(MAPK cascade)|interpro:IPR016024(Armadillo-type fold)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0002011"(morphogenesis of an epithelial sheet)|go:"GO:0003382"(epithelial cell morphogenesis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004706"(JUN kinase kinase kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007254"(JNK cascade)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008432"(JUN kinase binding)|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0016020"(membrane)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0031434"(mitogen-activated protein kinase kinase binding)|go:"GO:0031941"(filamentous actin)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0042060"(wound healing)|go:"GO:0043010"(camera-type eye development)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046625"(sphingolipid binding)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050434"(positive regulation of viral transcription)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0061029"(eyelid development in camera-type eye)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|reactome:R-RNO-166058|reactome:R-RNO-2871796|reactome:R-RNO-975138|reactome:R-RNO-975871|interpro:IPR011989(Armadillo-like helical)|mint:Q62925	refseq:NP_001027459.1|refseq:NP_068823.2|refseq:NP_071887.1|refseq:NP_954595.1|refseq:NP_954673.1|refseq:NP_001244322.1|refseq:NP_001244323.1|refseq:NP_001244325.1|ensembl:ENSG00000244687(gene)|ensembl:ENST00000371674(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006282"(regulation of DNA repair)|go:"GO:0006301"(postreplication repair)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0030154"(cell differentiation)|go:"GO:0031371"(ubiquitin conjugating enzyme complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035370"(UBC13-UEV1A complex)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070534"(protein K63-linked ubiquitination)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|rcsb pdb:2A4D|rcsb pdb:2C2V|rcsb pdb:2HLW|rcsb pdb:6D6I|reactome:R-HSA-168638|reactome:R-HSA-168927|reactome:R-HSA-202424|reactome:R-HSA-2871837|reactome:R-HSA-445989|reactome:R-HSA-450302|reactome:R-HSA-450321|reactome:R-HSA-5607764|reactome:R-HSA-9020702|reactome:R-HSA-937039|reactome:R-HSA-937041|reactome:R-HSA-9646399|reactome:R-HSA-975110|reactome:R-HSA-975144|reactome:R-HSA-983168|dip:DIP-41911N	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S3|resulting-ptm:P54252 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2018/01/16	rogid:EwhjYjowkZIAt4UyPcZBUtf9uak10116	rogid:x95N7Dj2KIqu5gySX59xLmfthUg9606	intact-crc:FB9345214677E3B9|rigid:Q2ZoTZo4+mgcPikAF5SFPhwB4mQ	false	sufficient binding region:433-481(IPR013083)	his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q62925	uniprotkb:P22314	intact:EBI-636664	intact:EBI-709688|uniprotkb:Q96E13|uniprotkb:Q5JRR8|ensembl:ENSP00000338413|ensembl:ENSP00000366568	psi-mi:m3k1_rat(display_long)|uniprotkb:MAPK/ERK kinase kinase 1(gene name synonym)|uniprotkb:Map3k1(gene name)|psi-mi:Map3k1(display_short)|uniprotkb:Mekk(gene name synonym)|uniprotkb:Mekk1(gene name synonym)	psi-mi:uba1_human(display_long)|uniprotkb:Ubiquitin-activating enzyme E1(gene name synonym)|uniprotkb:Protein A1S9(gene name synonym)|uniprotkb:UBA1(gene name)|psi-mi:UBA1(display_short)|uniprotkb:A1S9T(gene name synonym)|uniprotkb:UBE1(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9971635|imex:IM-22822-79	author-confidence:Z-score = 6.53	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:620966|refseq:NP_446339.1|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR007527(Zinc finger, SWIM-type)|go:"GO:0000165"(MAPK cascade)|interpro:IPR016024(Armadillo-type fold)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0002011"(morphogenesis of an epithelial sheet)|go:"GO:0003382"(epithelial cell morphogenesis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004706"(JUN kinase kinase kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007254"(JNK cascade)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008432"(JUN kinase binding)|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0016020"(membrane)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0031434"(mitogen-activated protein kinase kinase binding)|go:"GO:0031941"(filamentous actin)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0042060"(wound healing)|go:"GO:0043010"(camera-type eye development)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046625"(sphingolipid binding)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050434"(positive regulation of viral transcription)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0061029"(eyelid development in camera-type eye)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|reactome:R-RNO-166058|reactome:R-RNO-2871796|reactome:R-RNO-975138|reactome:R-RNO-975871|interpro:IPR011989(Armadillo-like helical)|mint:Q62925	refseq:NP_003325.2|refseq:NP_695012.1|refseq:XP_016885269.1|refseq:XP_016885270.1|dip:DIP-33686N|ensembl:ENSG00000130985(gene)|ensembl:ENST00000335972(transcript)|ensembl:ENST00000377351(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0004839"(ubiquitin activating enzyme activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0032446"(protein modification by small protein conjugation)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000011(Ubiquitin-activating enzyme, E1)|interpro:IPR000594(UBA/THIF-type NAD/FAD binding fold)|interpro:IPR018074|interpro:IPR018075|interpro:IPR018965|interpro:IPR019572|interpro:IPR032418|interpro:IPR032420|interpro:IPR033127|interpro:IPR035985|interpro:IPR038252|interpro:IPR042063|interpro:IPR042302|interpro:IPR042449|mint:P22314|rcsb pdb:4P22|rcsb pdb:6DC6|reactome:R-HSA-8866652|reactome:R-HSA-983168	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S3|resulting-ptm:P54252 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2018/01/16	rogid:EwhjYjowkZIAt4UyPcZBUtf9uak10116	rogid:q+vEeA0XLST0Zz173bmEt0dNbDE9606	intact-crc:FB9345214677E3B9|rigid:Q2ZoTZo4+mgcPikAF5SFPhwB4mQ	false	sufficient binding region:433-481(IPR013083)	his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q62925	uniprotkb:P61088	intact:EBI-636664	intact:EBI-1052908|uniprotkb:Q16781|uniprotkb:Q53Y81|ensembl:ENSP00000316176	psi-mi:m3k1_rat(display_long)|uniprotkb:MAPK/ERK kinase kinase 1(gene name synonym)|uniprotkb:Map3k1(gene name)|psi-mi:Map3k1(display_short)|uniprotkb:Mekk(gene name synonym)|uniprotkb:Mekk1(gene name synonym)	psi-mi:ube2n_human(display_long)|uniprotkb:Ubiquitin-protein ligase N(gene name synonym)|uniprotkb:Ubiquitin carrier protein N(gene name synonym)|uniprotkb:Ubc13(gene name synonym)|uniprotkb:Bendless-like ubiquitin-conjugating enzyme(gene name synonym)|uniprotkb:UBE2N(gene name)|psi-mi:UBE2N(display_short)|uniprotkb:BLU(gene name synonym)|uniprotkb:UbcH13(gene name synonym)|uniprotkb:E2 ubiquitin-conjugating enzyme N(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9971635|imex:IM-22822-79	author-confidence:Z-score = 6.53	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:620966|refseq:NP_446339.1|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR007527(Zinc finger, SWIM-type)|go:"GO:0000165"(MAPK cascade)|interpro:IPR016024(Armadillo-type fold)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0002011"(morphogenesis of an epithelial sheet)|go:"GO:0003382"(epithelial cell morphogenesis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004706"(JUN kinase kinase kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007254"(JNK cascade)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008432"(JUN kinase binding)|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0016020"(membrane)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0031434"(mitogen-activated protein kinase kinase binding)|go:"GO:0031941"(filamentous actin)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0042060"(wound healing)|go:"GO:0043010"(camera-type eye development)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046625"(sphingolipid binding)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050434"(positive regulation of viral transcription)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0061029"(eyelid development in camera-type eye)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|reactome:R-RNO-166058|reactome:R-RNO-2871796|reactome:R-RNO-975138|reactome:R-RNO-975871|interpro:IPR011989(Armadillo-like helical)|mint:Q62925	refseq:NP_003339.1|dip:DIP-29829N|ensembl:ENSG00000177889(gene)|ensembl:ENST00000318066(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000729"(DNA double-strand break processing)|go:"GO:0001650"(fibrillar center)|go:"GO:0003723"(RNA binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006282"(regulation of DNA repair)|go:"GO:0006301"(postreplication repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016574"(histone ubiquitination)|go:"GO:0031058"(positive regulation of histone modification)|go:"GO:0031372"(UBC13-MMS2 complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033182"(regulation of histone ubiquitination)|go:"GO:0035370"(UBC13-UEV1A complex)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0061631"(ubiquitin conjugating enzyme activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070534"(protein K63-linked ubiquitination)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|interpro:IPR023313|rcsb pdb:1J7D|rcsb pdb:2C2V|rcsb pdb:3HCT|rcsb pdb:3HCU|rcsb pdb:3VON|rcsb pdb:3W31|rcsb pdb:4DHI|rcsb pdb:4DHJ|rcsb pdb:4DHZ|rcsb pdb:4IP3|rcsb pdb:4NR3|rcsb pdb:4NRG|rcsb pdb:4NRI|rcsb pdb:4ONL|rcsb pdb:4ONM|rcsb pdb:4ONN|rcsb pdb:4ORH|rcsb pdb:4TKP|rcsb pdb:4WHV|rcsb pdb:5AIT|rcsb pdb:5AIU|rcsb pdb:5EYA|rcsb pdb:5H7S|rcsb pdb:5VNZ|rcsb pdb:5VO0|rcsb pdb:5YWR|rcsb pdb:6D6I|rcsb pdb:6JKY|rcsb pdb:6KFP|rcsb pdb:6KG6|rcsb pdb:6KL4|rcsb pdb:6LP2|rcsb pdb:6P5B|rcsb pdb:6S53|reactome:R-HSA-168927|reactome:R-HSA-202424|reactome:R-HSA-2871837|reactome:R-HSA-445989|reactome:R-HSA-450302|reactome:R-HSA-450321|reactome:R-HSA-5607764|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-5696395|reactome:R-HSA-69473|reactome:R-HSA-8866654|reactome:R-HSA-9020702|reactome:R-HSA-937039|reactome:R-HSA-937041|reactome:R-HSA-9646399|reactome:R-HSA-975110|reactome:R-HSA-975144|reactome:R-HSA-983168|rcsb pdb:6ULH|rcsb pdb:6UMP|rcsb pdb:6UMS|rcsb pdb:7BBD|rcsb pdb:7BBF|rcsb pdb:7BXG|reactome:R-HSA-1169408|reactome:R-HSA-168638	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S3|resulting-ptm:P54252 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2018/01/16	rogid:EwhjYjowkZIAt4UyPcZBUtf9uak10116	rogid:dqdszHlq5FLPHC6UWX6uvkC6Yz89606	intact-crc:FB9345214677E3B9|rigid:Q2ZoTZo4+mgcPikAF5SFPhwB4mQ	false	sufficient binding region:433-481(IPR013083)	his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q62925	uniprotkb:P54725	intact:EBI-636664	intact:EBI-746453|uniprotkb:Q59EU8|uniprotkb:Q5M7Z1|uniprotkb:K7ESE3|ensembl:ENSP00000467024	psi-mi:m3k1_rat(display_long)|uniprotkb:MAPK/ERK kinase kinase 1(gene name synonym)|uniprotkb:Map3k1(gene name)|psi-mi:Map3k1(display_short)|uniprotkb:Mekk(gene name synonym)|uniprotkb:Mekk1(gene name synonym)	psi-mi:rd23a_human(display_long)|uniprotkb:RAD23A(gene name)|psi-mi:RAD23A(display_short)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9971660|imex:IM-22822-80	author-confidence:Z-score = 10.77	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:620966|refseq:NP_446339.1|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR007527(Zinc finger, SWIM-type)|go:"GO:0000165"(MAPK cascade)|interpro:IPR016024(Armadillo-type fold)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0002011"(morphogenesis of an epithelial sheet)|go:"GO:0003382"(epithelial cell morphogenesis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004706"(JUN kinase kinase kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007254"(JNK cascade)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008432"(JUN kinase binding)|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0016020"(membrane)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0031434"(mitogen-activated protein kinase kinase binding)|go:"GO:0031941"(filamentous actin)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0042060"(wound healing)|go:"GO:0043010"(camera-type eye development)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046625"(sphingolipid binding)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050434"(positive regulation of viral transcription)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0061029"(eyelid development in camera-type eye)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|reactome:R-RNO-166058|reactome:R-RNO-2871796|reactome:R-RNO-975138|reactome:R-RNO-975871|interpro:IPR011989(Armadillo-like helical)|mint:Q62925	refseq:NP_005044.1|refseq:NP_001257291.1|refseq:NP_001257292.1|dip:DIP-34442N|ensembl:ENSG00000179262(gene)|ensembl:ENST00000586534(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006289"(nucleotide-excision repair)|go:"GO:0019900"(kinase binding)|go:"GO:0031593"(polyubiquitin modification-dependent protein binding)|go:"GO:0031648"(protein destabilization)|go:"GO:0032434"(regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034451"(centriolar satellite)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045070"(positive regulation of viral genome replication)|go:"GO:0045787"(positive regulation of cell cycle)|go:"GO:0070628"(proteasome binding)|go:"GO:1990381"(ubiquitin-specific protease binding)|interpro:IPR000626(Ubiquitin)|interpro:IPR004806(UV excision repair protein Rad23)|interpro:IPR006636(Heat shock chaperonin-binding)|interpro:IPR009060(UBA-like)|interpro:IPR015360(XPC-binding domain)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR029071|interpro:IPR036353|interpro:IPR041811|mint:P54725|rcsb pdb:1DV0|rcsb pdb:1F4I|rcsb pdb:1IFY|rcsb pdb:1OQY|rcsb pdb:1P98|rcsb pdb:1P9D|rcsb pdb:1QZE|rcsb pdb:1TP4|rcsb pdb:1ZO6|rcsb pdb:2WYQ|rcsb pdb:5XBO|rcsb pdb:6W2G|rcsb pdb:6W2H|rcsb pdb:6W2I|reactome:R-HSA-5689877|reactome:R-HSA-5696394|reactome:R-HSA-5696395	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S3|resulting-ptm:P54725 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:EwhjYjowkZIAt4UyPcZBUtf9uak10116	rogid:l/29QSvlTrWQMG3wLyeb/QxeaiU9606	intact-crc:E3FFE7CA3BABAA6E|rigid:KcUhJDwyMRaO4ScO1+AvQzfw78U	false	sufficient binding region:433-481(IPR013083)	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q62925	uniprotkb:Q13404	intact:EBI-636664	intact:EBI-1050671|uniprotkb:Q13403|uniprotkb:Q13532|uniprotkb:Q96H34|uniprotkb:Q9GZT0|uniprotkb:Q9GZW1|uniprotkb:Q9H4J3|uniprotkb:Q9H4J4|uniprotkb:Q9UKL1|uniprotkb:Q9UM48|uniprotkb:Q9UM49|uniprotkb:Q9UM50|uniprotkb:Q5TGE3|uniprotkb:E1P629|uniprotkb:Q5TGE0|ensembl:ENSP00000360739	psi-mi:m3k1_rat(display_long)|uniprotkb:MAPK/ERK kinase kinase 1(gene name synonym)|uniprotkb:Map3k1(gene name)|psi-mi:Map3k1(display_short)|uniprotkb:Mekk(gene name synonym)|uniprotkb:Mekk1(gene name synonym)	psi-mi:ub2v1_human(display_long)|uniprotkb:CROC-1(gene name synonym)|uniprotkb:TRAF6-regulated IKK activator 1 beta Uev1A(gene name synonym)|uniprotkb:P/OKcl.19(orf name)|uniprotkb:UBE2V1(gene name)|psi-mi:UBE2V1(display_short)|uniprotkb:CROC1(gene name synonym)|uniprotkb:UBE2V(gene name synonym)|uniprotkb:UEV1(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9971660|imex:IM-22822-80	author-confidence:Z-score = 10.77	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:620966|refseq:NP_446339.1|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR007527(Zinc finger, SWIM-type)|go:"GO:0000165"(MAPK cascade)|interpro:IPR016024(Armadillo-type fold)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0002011"(morphogenesis of an epithelial sheet)|go:"GO:0003382"(epithelial cell morphogenesis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004706"(JUN kinase kinase kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007254"(JNK cascade)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008432"(JUN kinase binding)|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0016020"(membrane)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0031434"(mitogen-activated protein kinase kinase binding)|go:"GO:0031941"(filamentous actin)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0042060"(wound healing)|go:"GO:0043010"(camera-type eye development)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046625"(sphingolipid binding)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050434"(positive regulation of viral transcription)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0061029"(eyelid development in camera-type eye)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|reactome:R-RNO-166058|reactome:R-RNO-2871796|reactome:R-RNO-975138|reactome:R-RNO-975871|interpro:IPR011989(Armadillo-like helical)|mint:Q62925	refseq:NP_001027459.1|refseq:NP_068823.2|refseq:NP_071887.1|refseq:NP_954595.1|refseq:NP_954673.1|refseq:NP_001244322.1|refseq:NP_001244323.1|refseq:NP_001244325.1|ensembl:ENSG00000244687(gene)|ensembl:ENST00000371674(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006282"(regulation of DNA repair)|go:"GO:0006301"(postreplication repair)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0030154"(cell differentiation)|go:"GO:0031371"(ubiquitin conjugating enzyme complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035370"(UBC13-UEV1A complex)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070534"(protein K63-linked ubiquitination)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|rcsb pdb:2A4D|rcsb pdb:2C2V|rcsb pdb:2HLW|rcsb pdb:6D6I|reactome:R-HSA-168638|reactome:R-HSA-168927|reactome:R-HSA-202424|reactome:R-HSA-2871837|reactome:R-HSA-445989|reactome:R-HSA-450302|reactome:R-HSA-450321|reactome:R-HSA-5607764|reactome:R-HSA-9020702|reactome:R-HSA-937039|reactome:R-HSA-937041|reactome:R-HSA-9646399|reactome:R-HSA-975110|reactome:R-HSA-975144|reactome:R-HSA-983168|dip:DIP-41911N	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S3|resulting-ptm:P54725 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:EwhjYjowkZIAt4UyPcZBUtf9uak10116	rogid:x95N7Dj2KIqu5gySX59xLmfthUg9606	intact-crc:E3FFE7CA3BABAA6E|rigid:KcUhJDwyMRaO4ScO1+AvQzfw78U	false	sufficient binding region:433-481(IPR013083)	his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q62925	uniprotkb:P22314	intact:EBI-636664	intact:EBI-709688|uniprotkb:Q96E13|uniprotkb:Q5JRR8|ensembl:ENSP00000338413|ensembl:ENSP00000366568	psi-mi:m3k1_rat(display_long)|uniprotkb:MAPK/ERK kinase kinase 1(gene name synonym)|uniprotkb:Map3k1(gene name)|psi-mi:Map3k1(display_short)|uniprotkb:Mekk(gene name synonym)|uniprotkb:Mekk1(gene name synonym)	psi-mi:uba1_human(display_long)|uniprotkb:Ubiquitin-activating enzyme E1(gene name synonym)|uniprotkb:Protein A1S9(gene name synonym)|uniprotkb:UBA1(gene name)|psi-mi:UBA1(display_short)|uniprotkb:A1S9T(gene name synonym)|uniprotkb:UBE1(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9971660|imex:IM-22822-80	author-confidence:Z-score = 10.77	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:620966|refseq:NP_446339.1|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR007527(Zinc finger, SWIM-type)|go:"GO:0000165"(MAPK cascade)|interpro:IPR016024(Armadillo-type fold)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0002011"(morphogenesis of an epithelial sheet)|go:"GO:0003382"(epithelial cell morphogenesis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004706"(JUN kinase kinase kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007254"(JNK cascade)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008432"(JUN kinase binding)|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0016020"(membrane)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0031434"(mitogen-activated protein kinase kinase binding)|go:"GO:0031941"(filamentous actin)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0042060"(wound healing)|go:"GO:0043010"(camera-type eye development)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046625"(sphingolipid binding)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050434"(positive regulation of viral transcription)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0061029"(eyelid development in camera-type eye)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|reactome:R-RNO-166058|reactome:R-RNO-2871796|reactome:R-RNO-975138|reactome:R-RNO-975871|interpro:IPR011989(Armadillo-like helical)|mint:Q62925	refseq:NP_003325.2|refseq:NP_695012.1|refseq:XP_016885269.1|refseq:XP_016885270.1|dip:DIP-33686N|ensembl:ENSG00000130985(gene)|ensembl:ENST00000335972(transcript)|ensembl:ENST00000377351(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0004839"(ubiquitin activating enzyme activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0032446"(protein modification by small protein conjugation)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000011(Ubiquitin-activating enzyme, E1)|interpro:IPR000594(UBA/THIF-type NAD/FAD binding fold)|interpro:IPR018074|interpro:IPR018075|interpro:IPR018965|interpro:IPR019572|interpro:IPR032418|interpro:IPR032420|interpro:IPR033127|interpro:IPR035985|interpro:IPR038252|interpro:IPR042063|interpro:IPR042302|interpro:IPR042449|mint:P22314|rcsb pdb:4P22|rcsb pdb:6DC6|reactome:R-HSA-8866652|reactome:R-HSA-983168	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S3|resulting-ptm:P54725 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:EwhjYjowkZIAt4UyPcZBUtf9uak10116	rogid:q+vEeA0XLST0Zz173bmEt0dNbDE9606	intact-crc:E3FFE7CA3BABAA6E|rigid:KcUhJDwyMRaO4ScO1+AvQzfw78U	false	sufficient binding region:433-481(IPR013083)	his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q62925	uniprotkb:P61088	intact:EBI-636664	intact:EBI-1052908|uniprotkb:Q16781|uniprotkb:Q53Y81|ensembl:ENSP00000316176	psi-mi:m3k1_rat(display_long)|uniprotkb:MAPK/ERK kinase kinase 1(gene name synonym)|uniprotkb:Map3k1(gene name)|psi-mi:Map3k1(display_short)|uniprotkb:Mekk(gene name synonym)|uniprotkb:Mekk1(gene name synonym)	psi-mi:ube2n_human(display_long)|uniprotkb:Ubiquitin-protein ligase N(gene name synonym)|uniprotkb:Ubiquitin carrier protein N(gene name synonym)|uniprotkb:Ubc13(gene name synonym)|uniprotkb:Bendless-like ubiquitin-conjugating enzyme(gene name synonym)|uniprotkb:UBE2N(gene name)|psi-mi:UBE2N(display_short)|uniprotkb:BLU(gene name synonym)|uniprotkb:UbcH13(gene name synonym)|uniprotkb:E2 ubiquitin-conjugating enzyme N(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9971660|imex:IM-22822-80	author-confidence:Z-score = 10.77	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:620966|refseq:NP_446339.1|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR007527(Zinc finger, SWIM-type)|go:"GO:0000165"(MAPK cascade)|interpro:IPR016024(Armadillo-type fold)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0002011"(morphogenesis of an epithelial sheet)|go:"GO:0003382"(epithelial cell morphogenesis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004706"(JUN kinase kinase kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007254"(JNK cascade)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008432"(JUN kinase binding)|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0016020"(membrane)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0031434"(mitogen-activated protein kinase kinase binding)|go:"GO:0031941"(filamentous actin)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0042060"(wound healing)|go:"GO:0043010"(camera-type eye development)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046625"(sphingolipid binding)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050434"(positive regulation of viral transcription)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0061029"(eyelid development in camera-type eye)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|reactome:R-RNO-166058|reactome:R-RNO-2871796|reactome:R-RNO-975138|reactome:R-RNO-975871|interpro:IPR011989(Armadillo-like helical)|mint:Q62925	refseq:NP_003339.1|dip:DIP-29829N|ensembl:ENSG00000177889(gene)|ensembl:ENST00000318066(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000729"(DNA double-strand break processing)|go:"GO:0001650"(fibrillar center)|go:"GO:0003723"(RNA binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006282"(regulation of DNA repair)|go:"GO:0006301"(postreplication repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016574"(histone ubiquitination)|go:"GO:0031058"(positive regulation of histone modification)|go:"GO:0031372"(UBC13-MMS2 complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033182"(regulation of histone ubiquitination)|go:"GO:0035370"(UBC13-UEV1A complex)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0061631"(ubiquitin conjugating enzyme activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070534"(protein K63-linked ubiquitination)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|interpro:IPR023313|rcsb pdb:1J7D|rcsb pdb:2C2V|rcsb pdb:3HCT|rcsb pdb:3HCU|rcsb pdb:3VON|rcsb pdb:3W31|rcsb pdb:4DHI|rcsb pdb:4DHJ|rcsb pdb:4DHZ|rcsb pdb:4IP3|rcsb pdb:4NR3|rcsb pdb:4NRG|rcsb pdb:4NRI|rcsb pdb:4ONL|rcsb pdb:4ONM|rcsb pdb:4ONN|rcsb pdb:4ORH|rcsb pdb:4TKP|rcsb pdb:4WHV|rcsb pdb:5AIT|rcsb pdb:5AIU|rcsb pdb:5EYA|rcsb pdb:5H7S|rcsb pdb:5VNZ|rcsb pdb:5VO0|rcsb pdb:5YWR|rcsb pdb:6D6I|rcsb pdb:6JKY|rcsb pdb:6KFP|rcsb pdb:6KG6|rcsb pdb:6KL4|rcsb pdb:6LP2|rcsb pdb:6P5B|rcsb pdb:6S53|reactome:R-HSA-168927|reactome:R-HSA-202424|reactome:R-HSA-2871837|reactome:R-HSA-445989|reactome:R-HSA-450302|reactome:R-HSA-450321|reactome:R-HSA-5607764|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-5696395|reactome:R-HSA-69473|reactome:R-HSA-8866654|reactome:R-HSA-9020702|reactome:R-HSA-937039|reactome:R-HSA-937041|reactome:R-HSA-9646399|reactome:R-HSA-975110|reactome:R-HSA-975144|reactome:R-HSA-983168|rcsb pdb:6ULH|rcsb pdb:6UMP|rcsb pdb:6UMS|rcsb pdb:7BBD|rcsb pdb:7BBF|rcsb pdb:7BXG|reactome:R-HSA-1169408|reactome:R-HSA-168638	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S3|resulting-ptm:P54725 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:EwhjYjowkZIAt4UyPcZBUtf9uak10116	rogid:dqdszHlq5FLPHC6UWX6uvkC6Yz89606	intact-crc:E3FFE7CA3BABAA6E|rigid:KcUhJDwyMRaO4ScO1+AvQzfw78U	false	sufficient binding region:433-481(IPR013083)	his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q62925	uniprotkb:P55036	intact:EBI-636664	intact:EBI-359318|uniprotkb:Q5VWC5|uniprotkb:Q9NS92|uniprotkb:D3DV16|ensembl:ENSP00000357879	psi-mi:m3k1_rat(display_long)|uniprotkb:MAPK/ERK kinase kinase 1(gene name synonym)|uniprotkb:Map3k1(gene name)|psi-mi:Map3k1(display_short)|uniprotkb:Mekk(gene name synonym)|uniprotkb:Mekk1(gene name synonym)	psi-mi:psmd4_human(display_long)|uniprotkb:PSMD4(gene name)|psi-mi:PSMD4(display_short)|uniprotkb:MCB1(gene name synonym)|uniprotkb:26S proteasome regulatory subunit S5A(gene name synonym)|uniprotkb:26S proteasome regulatory subunit RPN10(gene name synonym)|uniprotkb:Multiubiquitin chain-binding protein(gene name synonym)|uniprotkb:Antisecretory factor 1(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9971685|imex:IM-22822-81	author-confidence:Z-score = 7.47	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:620966|refseq:NP_446339.1|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR007527(Zinc finger, SWIM-type)|go:"GO:0000165"(MAPK cascade)|interpro:IPR016024(Armadillo-type fold)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0002011"(morphogenesis of an epithelial sheet)|go:"GO:0003382"(epithelial cell morphogenesis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004706"(JUN kinase kinase kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007254"(JNK cascade)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008432"(JUN kinase binding)|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0016020"(membrane)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0031434"(mitogen-activated protein kinase kinase binding)|go:"GO:0031941"(filamentous actin)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0042060"(wound healing)|go:"GO:0043010"(camera-type eye development)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046625"(sphingolipid binding)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050434"(positive regulation of viral transcription)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0061029"(eyelid development in camera-type eye)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|reactome:R-RNO-166058|reactome:R-RNO-2871796|reactome:R-RNO-975138|reactome:R-RNO-975871|interpro:IPR011989(Armadillo-like helical)|mint:Q62925	refseq:NP_002801.1|dip:DIP-38189N|ensembl:ENSG00000159352(gene)|ensembl:ENST00000368884(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0008540"(proteasome regulatory particle, base subcomplex)|go:"GO:0022624"(proteasome accessory complex)|go:"GO:0031593"(polyubiquitin modification-dependent protein binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043248"(proteasome assembly)|interpro:IPR002035(von Willebrand factor, type A)|interpro:IPR003903(Ubiquitin interacting motif)|interpro:IPR036465|mint:P55036|rcsb pdb:1P9C|rcsb pdb:1P9D|rcsb pdb:1UEL|rcsb pdb:1YX4|rcsb pdb:1YX5|rcsb pdb:1YX6|rcsb pdb:2KDE|rcsb pdb:2KDF|rcsb pdb:5GJQ|rcsb pdb:5GJR|rcsb pdb:5L4K|rcsb pdb:5LN3|rcsb pdb:5M32|rcsb pdb:5T0C|rcsb pdb:5T0G|rcsb pdb:5T0H|rcsb pdb:5T0I|rcsb pdb:5T0J|rcsb pdb:5VFP|rcsb pdb:5VFQ|rcsb pdb:5VFR|rcsb pdb:5VFS|rcsb pdb:5VFT|rcsb pdb:5VFU|rcsb pdb:5VGZ|rcsb pdb:5VHF|rcsb pdb:5VHH|rcsb pdb:5VHI|rcsb pdb:5VHS|rcsb pdb:6MSB|rcsb pdb:6MSD|rcsb pdb:6MSE|rcsb pdb:6MSG|rcsb pdb:6MSH|rcsb pdb:6MSJ|rcsb pdb:6MSK|rcsb pdb:6MUN|rcsb pdb:6U19|rcsb pdb:6WJD|rcsb pdb:6WJN|reactome:R-HSA-1169091|reactome:R-HSA-1234176|reactome:R-HSA-1236974|reactome:R-HSA-1236978|reactome:R-HSA-174084|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-180534|reactome:R-HSA-180585|reactome:R-HSA-187577|reactome:R-HSA-195253|reactome:R-HSA-202424|reactome:R-HSA-211733|reactome:R-HSA-2467813|reactome:R-HSA-2871837|reactome:R-HSA-349425|reactome:R-HSA-350562|reactome:R-HSA-382556|reactome:R-HSA-450408|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-4641258|reactome:R-HSA-5358346|reactome:R-HSA-5362768|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-5658442|reactome:R-HSA-5668541|reactome:R-HSA-5676590|reactome:R-HSA-5678895|reactome:R-HSA-5687128|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-68827|reactome:R-HSA-68949|reactome:R-HSA-69017|reactome:R-HSA-69481|reactome:R-HSA-69601|reactome:R-HSA-75815|reactome:R-HSA-8852276|reactome:R-HSA-8854050|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-8941858|reactome:R-HSA-8948751|reactome:R-HSA-8951664|reactome:R-HSA-9010553|reactome:R-HSA-9020702|reactome:R-HSA-9604323|reactome:R-HSA-983168	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S3|resulting-ptm:P55036 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:EwhjYjowkZIAt4UyPcZBUtf9uak10116	rogid:FTJG3ns3Ag/Y3xP3yEydGxppRcA9606	intact-crc:84F437909E66E8A1|rigid:dfGIJpoD5G3BOw0X4jDDIbrkDiI	false	sufficient binding region:433-481(IPR013083)	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q62925	uniprotkb:Q13404	intact:EBI-636664	intact:EBI-1050671|uniprotkb:Q13403|uniprotkb:Q13532|uniprotkb:Q96H34|uniprotkb:Q9GZT0|uniprotkb:Q9GZW1|uniprotkb:Q9H4J3|uniprotkb:Q9H4J4|uniprotkb:Q9UKL1|uniprotkb:Q9UM48|uniprotkb:Q9UM49|uniprotkb:Q9UM50|uniprotkb:Q5TGE3|uniprotkb:E1P629|uniprotkb:Q5TGE0|ensembl:ENSP00000360739	psi-mi:m3k1_rat(display_long)|uniprotkb:MAPK/ERK kinase kinase 1(gene name synonym)|uniprotkb:Map3k1(gene name)|psi-mi:Map3k1(display_short)|uniprotkb:Mekk(gene name synonym)|uniprotkb:Mekk1(gene name synonym)	psi-mi:ub2v1_human(display_long)|uniprotkb:CROC-1(gene name synonym)|uniprotkb:TRAF6-regulated IKK activator 1 beta Uev1A(gene name synonym)|uniprotkb:P/OKcl.19(orf name)|uniprotkb:UBE2V1(gene name)|psi-mi:UBE2V1(display_short)|uniprotkb:CROC1(gene name synonym)|uniprotkb:UBE2V(gene name synonym)|uniprotkb:UEV1(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9971685|imex:IM-22822-81	author-confidence:Z-score = 7.47	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:620966|refseq:NP_446339.1|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR007527(Zinc finger, SWIM-type)|go:"GO:0000165"(MAPK cascade)|interpro:IPR016024(Armadillo-type fold)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0002011"(morphogenesis of an epithelial sheet)|go:"GO:0003382"(epithelial cell morphogenesis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004706"(JUN kinase kinase kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007254"(JNK cascade)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008432"(JUN kinase binding)|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0016020"(membrane)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0031434"(mitogen-activated protein kinase kinase binding)|go:"GO:0031941"(filamentous actin)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0042060"(wound healing)|go:"GO:0043010"(camera-type eye development)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046625"(sphingolipid binding)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050434"(positive regulation of viral transcription)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0061029"(eyelid development in camera-type eye)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|reactome:R-RNO-166058|reactome:R-RNO-2871796|reactome:R-RNO-975138|reactome:R-RNO-975871|interpro:IPR011989(Armadillo-like helical)|mint:Q62925	refseq:NP_001027459.1|refseq:NP_068823.2|refseq:NP_071887.1|refseq:NP_954595.1|refseq:NP_954673.1|refseq:NP_001244322.1|refseq:NP_001244323.1|refseq:NP_001244325.1|ensembl:ENSG00000244687(gene)|ensembl:ENST00000371674(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006282"(regulation of DNA repair)|go:"GO:0006301"(postreplication repair)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0030154"(cell differentiation)|go:"GO:0031371"(ubiquitin conjugating enzyme complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035370"(UBC13-UEV1A complex)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070534"(protein K63-linked ubiquitination)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|rcsb pdb:2A4D|rcsb pdb:2C2V|rcsb pdb:2HLW|rcsb pdb:6D6I|reactome:R-HSA-168638|reactome:R-HSA-168927|reactome:R-HSA-202424|reactome:R-HSA-2871837|reactome:R-HSA-445989|reactome:R-HSA-450302|reactome:R-HSA-450321|reactome:R-HSA-5607764|reactome:R-HSA-9020702|reactome:R-HSA-937039|reactome:R-HSA-937041|reactome:R-HSA-9646399|reactome:R-HSA-975110|reactome:R-HSA-975144|reactome:R-HSA-983168|dip:DIP-41911N	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S3|resulting-ptm:P55036 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:EwhjYjowkZIAt4UyPcZBUtf9uak10116	rogid:x95N7Dj2KIqu5gySX59xLmfthUg9606	intact-crc:84F437909E66E8A1|rigid:dfGIJpoD5G3BOw0X4jDDIbrkDiI	false	sufficient binding region:433-481(IPR013083)	his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q62925	uniprotkb:P22314	intact:EBI-636664	intact:EBI-709688|uniprotkb:Q96E13|uniprotkb:Q5JRR8|ensembl:ENSP00000338413|ensembl:ENSP00000366568	psi-mi:m3k1_rat(display_long)|uniprotkb:MAPK/ERK kinase kinase 1(gene name synonym)|uniprotkb:Map3k1(gene name)|psi-mi:Map3k1(display_short)|uniprotkb:Mekk(gene name synonym)|uniprotkb:Mekk1(gene name synonym)	psi-mi:uba1_human(display_long)|uniprotkb:Ubiquitin-activating enzyme E1(gene name synonym)|uniprotkb:Protein A1S9(gene name synonym)|uniprotkb:UBA1(gene name)|psi-mi:UBA1(display_short)|uniprotkb:A1S9T(gene name synonym)|uniprotkb:UBE1(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9971685|imex:IM-22822-81	author-confidence:Z-score = 7.47	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:620966|refseq:NP_446339.1|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR007527(Zinc finger, SWIM-type)|go:"GO:0000165"(MAPK cascade)|interpro:IPR016024(Armadillo-type fold)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0002011"(morphogenesis of an epithelial sheet)|go:"GO:0003382"(epithelial cell morphogenesis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004706"(JUN kinase kinase kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007254"(JNK cascade)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008432"(JUN kinase binding)|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0016020"(membrane)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0031434"(mitogen-activated protein kinase kinase binding)|go:"GO:0031941"(filamentous actin)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0042060"(wound healing)|go:"GO:0043010"(camera-type eye development)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046625"(sphingolipid binding)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050434"(positive regulation of viral transcription)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0061029"(eyelid development in camera-type eye)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|reactome:R-RNO-166058|reactome:R-RNO-2871796|reactome:R-RNO-975138|reactome:R-RNO-975871|interpro:IPR011989(Armadillo-like helical)|mint:Q62925	refseq:NP_003325.2|refseq:NP_695012.1|refseq:XP_016885269.1|refseq:XP_016885270.1|dip:DIP-33686N|ensembl:ENSG00000130985(gene)|ensembl:ENST00000335972(transcript)|ensembl:ENST00000377351(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0004839"(ubiquitin activating enzyme activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0032446"(protein modification by small protein conjugation)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000011(Ubiquitin-activating enzyme, E1)|interpro:IPR000594(UBA/THIF-type NAD/FAD binding fold)|interpro:IPR018074|interpro:IPR018075|interpro:IPR018965|interpro:IPR019572|interpro:IPR032418|interpro:IPR032420|interpro:IPR033127|interpro:IPR035985|interpro:IPR038252|interpro:IPR042063|interpro:IPR042302|interpro:IPR042449|mint:P22314|rcsb pdb:4P22|rcsb pdb:6DC6|reactome:R-HSA-8866652|reactome:R-HSA-983168	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S3|resulting-ptm:P55036 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:EwhjYjowkZIAt4UyPcZBUtf9uak10116	rogid:q+vEeA0XLST0Zz173bmEt0dNbDE9606	intact-crc:84F437909E66E8A1|rigid:dfGIJpoD5G3BOw0X4jDDIbrkDiI	false	sufficient binding region:433-481(IPR013083)	his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q62925	uniprotkb:P61088	intact:EBI-636664	intact:EBI-1052908|uniprotkb:Q16781|uniprotkb:Q53Y81|ensembl:ENSP00000316176	psi-mi:m3k1_rat(display_long)|uniprotkb:MAPK/ERK kinase kinase 1(gene name synonym)|uniprotkb:Map3k1(gene name)|psi-mi:Map3k1(display_short)|uniprotkb:Mekk(gene name synonym)|uniprotkb:Mekk1(gene name synonym)	psi-mi:ube2n_human(display_long)|uniprotkb:Ubiquitin-protein ligase N(gene name synonym)|uniprotkb:Ubiquitin carrier protein N(gene name synonym)|uniprotkb:Ubc13(gene name synonym)|uniprotkb:Bendless-like ubiquitin-conjugating enzyme(gene name synonym)|uniprotkb:UBE2N(gene name)|psi-mi:UBE2N(display_short)|uniprotkb:BLU(gene name synonym)|uniprotkb:UbcH13(gene name synonym)|uniprotkb:E2 ubiquitin-conjugating enzyme N(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9971685|imex:IM-22822-81	author-confidence:Z-score = 7.47	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:620966|refseq:NP_446339.1|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR007527(Zinc finger, SWIM-type)|go:"GO:0000165"(MAPK cascade)|interpro:IPR016024(Armadillo-type fold)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0002011"(morphogenesis of an epithelial sheet)|go:"GO:0003382"(epithelial cell morphogenesis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004706"(JUN kinase kinase kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007254"(JNK cascade)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008432"(JUN kinase binding)|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0016020"(membrane)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0031434"(mitogen-activated protein kinase kinase binding)|go:"GO:0031941"(filamentous actin)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0042060"(wound healing)|go:"GO:0043010"(camera-type eye development)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046625"(sphingolipid binding)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050434"(positive regulation of viral transcription)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0061029"(eyelid development in camera-type eye)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|reactome:R-RNO-166058|reactome:R-RNO-2871796|reactome:R-RNO-975138|reactome:R-RNO-975871|interpro:IPR011989(Armadillo-like helical)|mint:Q62925	refseq:NP_003339.1|dip:DIP-29829N|ensembl:ENSG00000177889(gene)|ensembl:ENST00000318066(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000729"(DNA double-strand break processing)|go:"GO:0001650"(fibrillar center)|go:"GO:0003723"(RNA binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006282"(regulation of DNA repair)|go:"GO:0006301"(postreplication repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016574"(histone ubiquitination)|go:"GO:0031058"(positive regulation of histone modification)|go:"GO:0031372"(UBC13-MMS2 complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033182"(regulation of histone ubiquitination)|go:"GO:0035370"(UBC13-UEV1A complex)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0061631"(ubiquitin conjugating enzyme activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070534"(protein K63-linked ubiquitination)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|interpro:IPR023313|rcsb pdb:1J7D|rcsb pdb:2C2V|rcsb pdb:3HCT|rcsb pdb:3HCU|rcsb pdb:3VON|rcsb pdb:3W31|rcsb pdb:4DHI|rcsb pdb:4DHJ|rcsb pdb:4DHZ|rcsb pdb:4IP3|rcsb pdb:4NR3|rcsb pdb:4NRG|rcsb pdb:4NRI|rcsb pdb:4ONL|rcsb pdb:4ONM|rcsb pdb:4ONN|rcsb pdb:4ORH|rcsb pdb:4TKP|rcsb pdb:4WHV|rcsb pdb:5AIT|rcsb pdb:5AIU|rcsb pdb:5EYA|rcsb pdb:5H7S|rcsb pdb:5VNZ|rcsb pdb:5VO0|rcsb pdb:5YWR|rcsb pdb:6D6I|rcsb pdb:6JKY|rcsb pdb:6KFP|rcsb pdb:6KG6|rcsb pdb:6KL4|rcsb pdb:6LP2|rcsb pdb:6P5B|rcsb pdb:6S53|reactome:R-HSA-168927|reactome:R-HSA-202424|reactome:R-HSA-2871837|reactome:R-HSA-445989|reactome:R-HSA-450302|reactome:R-HSA-450321|reactome:R-HSA-5607764|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-5696395|reactome:R-HSA-69473|reactome:R-HSA-8866654|reactome:R-HSA-9020702|reactome:R-HSA-937039|reactome:R-HSA-937041|reactome:R-HSA-9646399|reactome:R-HSA-975110|reactome:R-HSA-975144|reactome:R-HSA-983168|rcsb pdb:6ULH|rcsb pdb:6UMP|rcsb pdb:6UMS|rcsb pdb:7BBD|rcsb pdb:7BBF|rcsb pdb:7BXG|reactome:R-HSA-1169408|reactome:R-HSA-168638	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S3|resulting-ptm:P55036 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:EwhjYjowkZIAt4UyPcZBUtf9uak10116	rogid:dqdszHlq5FLPHC6UWX6uvkC6Yz89606	intact-crc:84F437909E66E8A1|rigid:dfGIJpoD5G3BOw0X4jDDIbrkDiI	false	sufficient binding region:433-481(IPR013083)	his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q62925	uniprotkb:P61077	intact:EBI-636664	intact:EBI-348268|ensembl:ENSP00000318494|ensembl:ENSP00000337208|ensembl:ENSP00000378283|ensembl:ENSP00000396901|ensembl:ENSP00000344069|ensembl:ENSP00000378280|ensembl:ENSP00000378282|uniprotkb:A6NM99|intact:EBI-2809412|uniprotkb:P47986|uniprotkb:Q6IB88|uniprotkb:Q6NXS4|uniprotkb:Q8N924|uniprotkb:A6NJ93|uniprotkb:A6NJB1	psi-mi:m3k1_rat(display_long)|uniprotkb:MAPK/ERK kinase kinase 1(gene name synonym)|uniprotkb:Map3k1(gene name)|psi-mi:Map3k1(display_short)|uniprotkb:Mekk(gene name synonym)|uniprotkb:Mekk1(gene name synonym)	psi-mi:ub2d3_human(display_long)|uniprotkb:UBC5C(gene name synonym)|uniprotkb:Ubiquitin-protein ligase D3(gene name synonym)|uniprotkb:Ubiquitin carrier protein D3(gene name synonym)|uniprotkb:Ubiquitin-conjugating enzyme E2-17 kDa 3(gene name synonym)|uniprotkb:"Ubiquitin-conjugating enzyme E2(17)KB 3"(gene name synonym)|uniprotkb:UBE2D3(gene name)|psi-mi:UBE2D3(display_short)|uniprotkb:UBCH5C(gene name synonym)|uniprotkb:"(E3-independent) E2 ubiquitin-conjugating enzyme D3"(gene name synonym)|uniprotkb:E2 ubiquitin-conjugating enzyme D3(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9971710|imex:IM-22822-82	author-confidence:Z-score = 7.89	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:620966|refseq:NP_446339.1|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR007527(Zinc finger, SWIM-type)|go:"GO:0000165"(MAPK cascade)|interpro:IPR016024(Armadillo-type fold)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0002011"(morphogenesis of an epithelial sheet)|go:"GO:0003382"(epithelial cell morphogenesis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004706"(JUN kinase kinase kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007254"(JNK cascade)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008432"(JUN kinase binding)|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0016020"(membrane)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0031434"(mitogen-activated protein kinase kinase binding)|go:"GO:0031941"(filamentous actin)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0042060"(wound healing)|go:"GO:0043010"(camera-type eye development)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046625"(sphingolipid binding)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050434"(positive regulation of viral transcription)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0061029"(eyelid development in camera-type eye)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|reactome:R-RNO-166058|reactome:R-RNO-2871796|reactome:R-RNO-975138|reactome:R-RNO-975871|interpro:IPR011989(Armadillo-like helical)|mint:Q62925	ensembl:ENSG00000109332(gene)|ensembl:ENST00000321805(transcript)|ensembl:ENST00000338145(transcript)|ensembl:ENST00000349311(transcript)|ensembl:ENST00000394801(transcript)|ensembl:ENST00000394803(transcript)|ensembl:ENST00000394804(transcript)|ensembl:ENST00000453744(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006281"(DNA repair)|go:"GO:0006513"(protein monoubiquitination)|go:"GO:0006915"(apoptotic process)|go:"GO:0010008"(endosome membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0006464"(cellular protein modification process)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0061631"(ubiquitin conjugating enzyme activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070936"(protein K48-linked ubiquitination)|go:"GO:0070979"(protein K11-linked ubiquitination)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0071288"(cellular response to mercury ion)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|interpro:IPR023313|rcsb pdb:2FUH|rcsb pdb:3L1Z|rcsb pdb:3RPG|rcsb pdb:3UGB|rcsb pdb:4BVU|rcsb pdb:4R8P|rcsb pdb:4S3O|rcsb pdb:5EGG|rcsb pdb:5IFR|rcsb pdb:6CP0|rcsb pdb:6T7F|rcsb pdb:7JZV|reactome:R-HSA-1234176|reactome:R-HSA-168927|reactome:R-HSA-201451|reactome:R-HSA-2173795|reactome:R-HSA-8866654|reactome:R-HSA-8951664|reactome:R-HSA-9033241|reactome:R-HSA-936440|reactome:R-HSA-937041|reactome:R-HSA-9705462|reactome:R-HSA-983168|rcsb pdb:1X23|refseq:NP_003331.1|refseq:NP_871615.1|refseq:NP_871616.1|refseq:NP_871617.1|refseq:NP_871618.1|refseq:NP_871619.1|refseq:NP_871620.1|refseq:NP_871621.1|refseq:NP_871622.1|dip:DIP-29062N	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S3|resulting-ptm:P61077 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:EwhjYjowkZIAt4UyPcZBUtf9uak10116	rogid:jSQ4I+Cgli7HaN5S0OLUP+J5YXs9606	intact-crc:619BDC1F18DAAD98|rigid:gTDWQBNHO2QC2yCnfXpz8BHzG2A	false	sufficient binding region:433-481(IPR013083)	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q62925	uniprotkb:Q13404	intact:EBI-636664	intact:EBI-1050671|uniprotkb:Q13403|uniprotkb:Q13532|uniprotkb:Q96H34|uniprotkb:Q9GZT0|uniprotkb:Q9GZW1|uniprotkb:Q9H4J3|uniprotkb:Q9H4J4|uniprotkb:Q9UKL1|uniprotkb:Q9UM48|uniprotkb:Q9UM49|uniprotkb:Q9UM50|uniprotkb:Q5TGE3|uniprotkb:E1P629|uniprotkb:Q5TGE0|ensembl:ENSP00000360739	psi-mi:m3k1_rat(display_long)|uniprotkb:MAPK/ERK kinase kinase 1(gene name synonym)|uniprotkb:Map3k1(gene name)|psi-mi:Map3k1(display_short)|uniprotkb:Mekk(gene name synonym)|uniprotkb:Mekk1(gene name synonym)	psi-mi:ub2v1_human(display_long)|uniprotkb:CROC-1(gene name synonym)|uniprotkb:TRAF6-regulated IKK activator 1 beta Uev1A(gene name synonym)|uniprotkb:P/OKcl.19(orf name)|uniprotkb:UBE2V1(gene name)|psi-mi:UBE2V1(display_short)|uniprotkb:CROC1(gene name synonym)|uniprotkb:UBE2V(gene name synonym)|uniprotkb:UEV1(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9971710|imex:IM-22822-82	author-confidence:Z-score = 7.89	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:620966|refseq:NP_446339.1|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR007527(Zinc finger, SWIM-type)|go:"GO:0000165"(MAPK cascade)|interpro:IPR016024(Armadillo-type fold)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0002011"(morphogenesis of an epithelial sheet)|go:"GO:0003382"(epithelial cell morphogenesis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004706"(JUN kinase kinase kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007254"(JNK cascade)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008432"(JUN kinase binding)|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0016020"(membrane)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0031434"(mitogen-activated protein kinase kinase binding)|go:"GO:0031941"(filamentous actin)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0042060"(wound healing)|go:"GO:0043010"(camera-type eye development)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046625"(sphingolipid binding)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050434"(positive regulation of viral transcription)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0061029"(eyelid development in camera-type eye)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|reactome:R-RNO-166058|reactome:R-RNO-2871796|reactome:R-RNO-975138|reactome:R-RNO-975871|interpro:IPR011989(Armadillo-like helical)|mint:Q62925	refseq:NP_001027459.1|refseq:NP_068823.2|refseq:NP_071887.1|refseq:NP_954595.1|refseq:NP_954673.1|refseq:NP_001244322.1|refseq:NP_001244323.1|refseq:NP_001244325.1|ensembl:ENSG00000244687(gene)|ensembl:ENST00000371674(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006282"(regulation of DNA repair)|go:"GO:0006301"(postreplication repair)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0030154"(cell differentiation)|go:"GO:0031371"(ubiquitin conjugating enzyme complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035370"(UBC13-UEV1A complex)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070534"(protein K63-linked ubiquitination)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|rcsb pdb:2A4D|rcsb pdb:2C2V|rcsb pdb:2HLW|rcsb pdb:6D6I|reactome:R-HSA-168638|reactome:R-HSA-168927|reactome:R-HSA-202424|reactome:R-HSA-2871837|reactome:R-HSA-445989|reactome:R-HSA-450302|reactome:R-HSA-450321|reactome:R-HSA-5607764|reactome:R-HSA-9020702|reactome:R-HSA-937039|reactome:R-HSA-937041|reactome:R-HSA-9646399|reactome:R-HSA-975110|reactome:R-HSA-975144|reactome:R-HSA-983168|dip:DIP-41911N	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S3|resulting-ptm:P61077 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:EwhjYjowkZIAt4UyPcZBUtf9uak10116	rogid:x95N7Dj2KIqu5gySX59xLmfthUg9606	intact-crc:619BDC1F18DAAD98|rigid:gTDWQBNHO2QC2yCnfXpz8BHzG2A	false	sufficient binding region:433-481(IPR013083)	his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q62925	uniprotkb:P22314	intact:EBI-636664	intact:EBI-709688|uniprotkb:Q96E13|uniprotkb:Q5JRR8|ensembl:ENSP00000338413|ensembl:ENSP00000366568	psi-mi:m3k1_rat(display_long)|uniprotkb:MAPK/ERK kinase kinase 1(gene name synonym)|uniprotkb:Map3k1(gene name)|psi-mi:Map3k1(display_short)|uniprotkb:Mekk(gene name synonym)|uniprotkb:Mekk1(gene name synonym)	psi-mi:uba1_human(display_long)|uniprotkb:Ubiquitin-activating enzyme E1(gene name synonym)|uniprotkb:Protein A1S9(gene name synonym)|uniprotkb:UBA1(gene name)|psi-mi:UBA1(display_short)|uniprotkb:A1S9T(gene name synonym)|uniprotkb:UBE1(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9971710|imex:IM-22822-82	author-confidence:Z-score = 7.89	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:620966|refseq:NP_446339.1|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR007527(Zinc finger, SWIM-type)|go:"GO:0000165"(MAPK cascade)|interpro:IPR016024(Armadillo-type fold)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0002011"(morphogenesis of an epithelial sheet)|go:"GO:0003382"(epithelial cell morphogenesis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004706"(JUN kinase kinase kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007254"(JNK cascade)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008432"(JUN kinase binding)|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0016020"(membrane)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0031434"(mitogen-activated protein kinase kinase binding)|go:"GO:0031941"(filamentous actin)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0042060"(wound healing)|go:"GO:0043010"(camera-type eye development)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046625"(sphingolipid binding)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050434"(positive regulation of viral transcription)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0061029"(eyelid development in camera-type eye)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|reactome:R-RNO-166058|reactome:R-RNO-2871796|reactome:R-RNO-975138|reactome:R-RNO-975871|interpro:IPR011989(Armadillo-like helical)|mint:Q62925	refseq:NP_003325.2|refseq:NP_695012.1|refseq:XP_016885269.1|refseq:XP_016885270.1|dip:DIP-33686N|ensembl:ENSG00000130985(gene)|ensembl:ENST00000335972(transcript)|ensembl:ENST00000377351(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0004839"(ubiquitin activating enzyme activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0032446"(protein modification by small protein conjugation)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000011(Ubiquitin-activating enzyme, E1)|interpro:IPR000594(UBA/THIF-type NAD/FAD binding fold)|interpro:IPR018074|interpro:IPR018075|interpro:IPR018965|interpro:IPR019572|interpro:IPR032418|interpro:IPR032420|interpro:IPR033127|interpro:IPR035985|interpro:IPR038252|interpro:IPR042063|interpro:IPR042302|interpro:IPR042449|mint:P22314|rcsb pdb:4P22|rcsb pdb:6DC6|reactome:R-HSA-8866652|reactome:R-HSA-983168	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S3|resulting-ptm:P61077 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:EwhjYjowkZIAt4UyPcZBUtf9uak10116	rogid:q+vEeA0XLST0Zz173bmEt0dNbDE9606	intact-crc:619BDC1F18DAAD98|rigid:gTDWQBNHO2QC2yCnfXpz8BHzG2A	false	sufficient binding region:433-481(IPR013083)	his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q62925	uniprotkb:P61088	intact:EBI-636664	intact:EBI-1052908|uniprotkb:Q16781|uniprotkb:Q53Y81|ensembl:ENSP00000316176	psi-mi:m3k1_rat(display_long)|uniprotkb:MAPK/ERK kinase kinase 1(gene name synonym)|uniprotkb:Map3k1(gene name)|psi-mi:Map3k1(display_short)|uniprotkb:Mekk(gene name synonym)|uniprotkb:Mekk1(gene name synonym)	psi-mi:ube2n_human(display_long)|uniprotkb:Ubiquitin-protein ligase N(gene name synonym)|uniprotkb:Ubiquitin carrier protein N(gene name synonym)|uniprotkb:Ubc13(gene name synonym)|uniprotkb:Bendless-like ubiquitin-conjugating enzyme(gene name synonym)|uniprotkb:UBE2N(gene name)|psi-mi:UBE2N(display_short)|uniprotkb:BLU(gene name synonym)|uniprotkb:UbcH13(gene name synonym)|uniprotkb:E2 ubiquitin-conjugating enzyme N(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9971710|imex:IM-22822-82	author-confidence:Z-score = 7.89	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:620966|refseq:NP_446339.1|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR007527(Zinc finger, SWIM-type)|go:"GO:0000165"(MAPK cascade)|interpro:IPR016024(Armadillo-type fold)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0002011"(morphogenesis of an epithelial sheet)|go:"GO:0003382"(epithelial cell morphogenesis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004706"(JUN kinase kinase kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007254"(JNK cascade)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008432"(JUN kinase binding)|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0016020"(membrane)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0031434"(mitogen-activated protein kinase kinase binding)|go:"GO:0031941"(filamentous actin)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0042060"(wound healing)|go:"GO:0043010"(camera-type eye development)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046625"(sphingolipid binding)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050434"(positive regulation of viral transcription)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0061029"(eyelid development in camera-type eye)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|reactome:R-RNO-166058|reactome:R-RNO-2871796|reactome:R-RNO-975138|reactome:R-RNO-975871|interpro:IPR011989(Armadillo-like helical)|mint:Q62925	refseq:NP_003339.1|dip:DIP-29829N|ensembl:ENSG00000177889(gene)|ensembl:ENST00000318066(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000729"(DNA double-strand break processing)|go:"GO:0001650"(fibrillar center)|go:"GO:0003723"(RNA binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006282"(regulation of DNA repair)|go:"GO:0006301"(postreplication repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016574"(histone ubiquitination)|go:"GO:0031058"(positive regulation of histone modification)|go:"GO:0031372"(UBC13-MMS2 complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033182"(regulation of histone ubiquitination)|go:"GO:0035370"(UBC13-UEV1A complex)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0061631"(ubiquitin conjugating enzyme activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070534"(protein K63-linked ubiquitination)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|interpro:IPR023313|rcsb pdb:1J7D|rcsb pdb:2C2V|rcsb pdb:3HCT|rcsb pdb:3HCU|rcsb pdb:3VON|rcsb pdb:3W31|rcsb pdb:4DHI|rcsb pdb:4DHJ|rcsb pdb:4DHZ|rcsb pdb:4IP3|rcsb pdb:4NR3|rcsb pdb:4NRG|rcsb pdb:4NRI|rcsb pdb:4ONL|rcsb pdb:4ONM|rcsb pdb:4ONN|rcsb pdb:4ORH|rcsb pdb:4TKP|rcsb pdb:4WHV|rcsb pdb:5AIT|rcsb pdb:5AIU|rcsb pdb:5EYA|rcsb pdb:5H7S|rcsb pdb:5VNZ|rcsb pdb:5VO0|rcsb pdb:5YWR|rcsb pdb:6D6I|rcsb pdb:6JKY|rcsb pdb:6KFP|rcsb pdb:6KG6|rcsb pdb:6KL4|rcsb pdb:6LP2|rcsb pdb:6P5B|rcsb pdb:6S53|reactome:R-HSA-168927|reactome:R-HSA-202424|reactome:R-HSA-2871837|reactome:R-HSA-445989|reactome:R-HSA-450302|reactome:R-HSA-450321|reactome:R-HSA-5607764|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-5696395|reactome:R-HSA-69473|reactome:R-HSA-8866654|reactome:R-HSA-9020702|reactome:R-HSA-937039|reactome:R-HSA-937041|reactome:R-HSA-9646399|reactome:R-HSA-975110|reactome:R-HSA-975144|reactome:R-HSA-983168|rcsb pdb:6ULH|rcsb pdb:6UMP|rcsb pdb:6UMS|rcsb pdb:7BBD|rcsb pdb:7BBF|rcsb pdb:7BXG|reactome:R-HSA-1169408|reactome:R-HSA-168638	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S3|resulting-ptm:P61077 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:EwhjYjowkZIAt4UyPcZBUtf9uak10116	rogid:dqdszHlq5FLPHC6UWX6uvkC6Yz89606	intact-crc:619BDC1F18DAAD98|rigid:gTDWQBNHO2QC2yCnfXpz8BHzG2A	false	sufficient binding region:433-481(IPR013083)	his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q62925	uniprotkb:Q13404	intact:EBI-636664	intact:EBI-1050671|uniprotkb:Q13403|uniprotkb:Q13532|uniprotkb:Q96H34|uniprotkb:Q9GZT0|uniprotkb:Q9GZW1|uniprotkb:Q9H4J3|uniprotkb:Q9H4J4|uniprotkb:Q9UKL1|uniprotkb:Q9UM48|uniprotkb:Q9UM49|uniprotkb:Q9UM50|uniprotkb:Q5TGE3|uniprotkb:E1P629|uniprotkb:Q5TGE0|ensembl:ENSP00000360739	psi-mi:m3k1_rat(display_long)|uniprotkb:MAPK/ERK kinase kinase 1(gene name synonym)|uniprotkb:Map3k1(gene name)|psi-mi:Map3k1(display_short)|uniprotkb:Mekk(gene name synonym)|uniprotkb:Mekk1(gene name synonym)	psi-mi:ub2v1_human(display_long)|uniprotkb:CROC-1(gene name synonym)|uniprotkb:TRAF6-regulated IKK activator 1 beta Uev1A(gene name synonym)|uniprotkb:P/OKcl.19(orf name)|uniprotkb:UBE2V1(gene name)|psi-mi:UBE2V1(display_short)|uniprotkb:CROC1(gene name synonym)|uniprotkb:UBE2V(gene name synonym)|uniprotkb:UEV1(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9971735|imex:IM-22822-83	author-confidence:Z-score = 5.06	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:620966|refseq:NP_446339.1|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR007527(Zinc finger, SWIM-type)|go:"GO:0000165"(MAPK cascade)|interpro:IPR016024(Armadillo-type fold)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0002011"(morphogenesis of an epithelial sheet)|go:"GO:0003382"(epithelial cell morphogenesis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004706"(JUN kinase kinase kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007254"(JNK cascade)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008432"(JUN kinase binding)|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0016020"(membrane)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0031434"(mitogen-activated protein kinase kinase binding)|go:"GO:0031941"(filamentous actin)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0042060"(wound healing)|go:"GO:0043010"(camera-type eye development)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046625"(sphingolipid binding)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050434"(positive regulation of viral transcription)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0061029"(eyelid development in camera-type eye)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|reactome:R-RNO-166058|reactome:R-RNO-2871796|reactome:R-RNO-975138|reactome:R-RNO-975871|interpro:IPR011989(Armadillo-like helical)|mint:Q62925	refseq:NP_001027459.1|refseq:NP_068823.2|refseq:NP_071887.1|refseq:NP_954595.1|refseq:NP_954673.1|refseq:NP_001244322.1|refseq:NP_001244323.1|refseq:NP_001244325.1|ensembl:ENSG00000244687(gene)|ensembl:ENST00000371674(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006282"(regulation of DNA repair)|go:"GO:0006301"(postreplication repair)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0030154"(cell differentiation)|go:"GO:0031371"(ubiquitin conjugating enzyme complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035370"(UBC13-UEV1A complex)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070534"(protein K63-linked ubiquitination)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|rcsb pdb:2A4D|rcsb pdb:2C2V|rcsb pdb:2HLW|rcsb pdb:6D6I|reactome:R-HSA-168638|reactome:R-HSA-168927|reactome:R-HSA-202424|reactome:R-HSA-2871837|reactome:R-HSA-445989|reactome:R-HSA-450302|reactome:R-HSA-450321|reactome:R-HSA-5607764|reactome:R-HSA-9020702|reactome:R-HSA-937039|reactome:R-HSA-937041|reactome:R-HSA-9646399|reactome:R-HSA-975110|reactome:R-HSA-975144|reactome:R-HSA-983168|dip:DIP-41911N	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S3|resulting-ptm:P61086 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:EwhjYjowkZIAt4UyPcZBUtf9uak10116	rogid:x95N7Dj2KIqu5gySX59xLmfthUg9606	intact-crc:FFEDCB014F5A7C68|rigid:0jIh0QbCL9hzkDRznxTOt+f+fBY	false	sufficient binding region:433-481(IPR013083)	his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q62925	uniprotkb:P22314	intact:EBI-636664	intact:EBI-709688|uniprotkb:Q96E13|uniprotkb:Q5JRR8|ensembl:ENSP00000338413|ensembl:ENSP00000366568	psi-mi:m3k1_rat(display_long)|uniprotkb:MAPK/ERK kinase kinase 1(gene name synonym)|uniprotkb:Map3k1(gene name)|psi-mi:Map3k1(display_short)|uniprotkb:Mekk(gene name synonym)|uniprotkb:Mekk1(gene name synonym)	psi-mi:uba1_human(display_long)|uniprotkb:Ubiquitin-activating enzyme E1(gene name synonym)|uniprotkb:Protein A1S9(gene name synonym)|uniprotkb:UBA1(gene name)|psi-mi:UBA1(display_short)|uniprotkb:A1S9T(gene name synonym)|uniprotkb:UBE1(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9971735|imex:IM-22822-83	author-confidence:Z-score = 5.06	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:620966|refseq:NP_446339.1|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR007527(Zinc finger, SWIM-type)|go:"GO:0000165"(MAPK cascade)|interpro:IPR016024(Armadillo-type fold)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0002011"(morphogenesis of an epithelial sheet)|go:"GO:0003382"(epithelial cell morphogenesis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004706"(JUN kinase kinase kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007254"(JNK cascade)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008432"(JUN kinase binding)|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0016020"(membrane)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0031434"(mitogen-activated protein kinase kinase binding)|go:"GO:0031941"(filamentous actin)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0042060"(wound healing)|go:"GO:0043010"(camera-type eye development)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046625"(sphingolipid binding)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050434"(positive regulation of viral transcription)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0061029"(eyelid development in camera-type eye)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|reactome:R-RNO-166058|reactome:R-RNO-2871796|reactome:R-RNO-975138|reactome:R-RNO-975871|interpro:IPR011989(Armadillo-like helical)|mint:Q62925	refseq:NP_003325.2|refseq:NP_695012.1|refseq:XP_016885269.1|refseq:XP_016885270.1|dip:DIP-33686N|ensembl:ENSG00000130985(gene)|ensembl:ENST00000335972(transcript)|ensembl:ENST00000377351(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0004839"(ubiquitin activating enzyme activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0032446"(protein modification by small protein conjugation)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000011(Ubiquitin-activating enzyme, E1)|interpro:IPR000594(UBA/THIF-type NAD/FAD binding fold)|interpro:IPR018074|interpro:IPR018075|interpro:IPR018965|interpro:IPR019572|interpro:IPR032418|interpro:IPR032420|interpro:IPR033127|interpro:IPR035985|interpro:IPR038252|interpro:IPR042063|interpro:IPR042302|interpro:IPR042449|mint:P22314|rcsb pdb:4P22|rcsb pdb:6DC6|reactome:R-HSA-8866652|reactome:R-HSA-983168	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S3|resulting-ptm:P61086 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:EwhjYjowkZIAt4UyPcZBUtf9uak10116	rogid:q+vEeA0XLST0Zz173bmEt0dNbDE9606	intact-crc:FFEDCB014F5A7C68|rigid:0jIh0QbCL9hzkDRznxTOt+f+fBY	false	sufficient binding region:433-481(IPR013083)	his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q62925	uniprotkb:P61086	intact:EBI-636664	intact:EBI-473850|uniprotkb:A6NJC1|uniprotkb:O54806|uniprotkb:P27924|uniprotkb:Q16721|uniprotkb:Q9CVV9|uniprotkb:Q9Y2D3|uniprotkb:B2RDF8|uniprotkb:A8K5Y9|uniprotkb:C9JGP1|ensembl:ENSP00000261427	psi-mi:m3k1_rat(display_long)|uniprotkb:MAPK/ERK kinase kinase 1(gene name synonym)|uniprotkb:Map3k1(gene name)|psi-mi:Map3k1(display_short)|uniprotkb:Mekk(gene name synonym)|uniprotkb:Mekk1(gene name synonym)	psi-mi:ube2k_human(display_long)|uniprotkb:HIP2(gene name synonym)|uniprotkb:Ubiquitin-conjugating enzyme E2-25 kDa(gene name synonym)|uniprotkb:Ubiquitin-protein ligase(gene name synonym)|uniprotkb:Ubiquitin carrier protein(gene name synonym)|uniprotkb:Huntingtin-interacting protein 2(gene name synonym)|uniprotkb:UBE2K(gene name)|psi-mi:UBE2K(display_short)|uniprotkb:LIG(gene name synonym)|uniprotkb:E2 ubiquitin-conjugating enzyme K(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9971735|imex:IM-22822-83	author-confidence:Z-score = 5.06	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:620966|refseq:NP_446339.1|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR007527(Zinc finger, SWIM-type)|go:"GO:0000165"(MAPK cascade)|interpro:IPR016024(Armadillo-type fold)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0002011"(morphogenesis of an epithelial sheet)|go:"GO:0003382"(epithelial cell morphogenesis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004706"(JUN kinase kinase kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007254"(JNK cascade)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008432"(JUN kinase binding)|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0016020"(membrane)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0031434"(mitogen-activated protein kinase kinase binding)|go:"GO:0031941"(filamentous actin)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0042060"(wound healing)|go:"GO:0043010"(camera-type eye development)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046625"(sphingolipid binding)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050434"(positive regulation of viral transcription)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0061029"(eyelid development in camera-type eye)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|reactome:R-RNO-166058|reactome:R-RNO-2871796|reactome:R-RNO-975138|reactome:R-RNO-975871|interpro:IPR011989(Armadillo-like helical)|mint:Q62925	refseq:NP_001104582.1|refseq:NP_001104583.1|refseq:NP_005330.1|dip:DIP-32524N|ensembl:ENSG00000078140(gene)|ensembl:ENST00000261427(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0010800"(positive regulation of peptidyl-threonine phosphorylation)|go:"GO:0010994"(free ubiquitin chain polymerization)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032433"(filopodium tip)|go:"GO:0032434"(regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0034450"(ubiquitin-ubiquitin ligase activity)|go:"GO:0035458"(cellular response to interferon-beta)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0060340"(positive regulation of type I interferon-mediated signaling pathway)|go:"GO:0061631"(ubiquitin conjugating enzyme activity)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070936"(protein K48-linked ubiquitination)|go:"GO:1903265"(positive regulation of tumor necrosis factor-mediated signaling pathway)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR009060(UBA-like)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|interpro:IPR023313|interpro:IPR042599|rcsb pdb:1YLA|rcsb pdb:2O25|rcsb pdb:3E46|rcsb pdb:3F92|rcsb pdb:3K9O|rcsb pdb:3K9P|rcsb pdb:5DFL|rcsb pdb:6IF1|rcsb pdb:6JB6|rcsb pdb:6JB7|reactome:R-HSA-8866652|reactome:R-HSA-936440|reactome:R-HSA-983168	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S3|resulting-ptm:P61086 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:EwhjYjowkZIAt4UyPcZBUtf9uak10116	rogid:TTxSiXJ5fNdGUeuzYlPvDl8W7eg9606	intact-crc:FFEDCB014F5A7C68|rigid:0jIh0QbCL9hzkDRznxTOt+f+fBY	false	sufficient binding region:433-481(IPR013083)	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q62925	uniprotkb:P61088	intact:EBI-636664	intact:EBI-1052908|uniprotkb:Q16781|uniprotkb:Q53Y81|ensembl:ENSP00000316176	psi-mi:m3k1_rat(display_long)|uniprotkb:MAPK/ERK kinase kinase 1(gene name synonym)|uniprotkb:Map3k1(gene name)|psi-mi:Map3k1(display_short)|uniprotkb:Mekk(gene name synonym)|uniprotkb:Mekk1(gene name synonym)	psi-mi:ube2n_human(display_long)|uniprotkb:Ubiquitin-protein ligase N(gene name synonym)|uniprotkb:Ubiquitin carrier protein N(gene name synonym)|uniprotkb:Ubc13(gene name synonym)|uniprotkb:Bendless-like ubiquitin-conjugating enzyme(gene name synonym)|uniprotkb:UBE2N(gene name)|psi-mi:UBE2N(display_short)|uniprotkb:BLU(gene name synonym)|uniprotkb:UbcH13(gene name synonym)|uniprotkb:E2 ubiquitin-conjugating enzyme N(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9971735|imex:IM-22822-83	author-confidence:Z-score = 5.06	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:620966|refseq:NP_446339.1|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR007527(Zinc finger, SWIM-type)|go:"GO:0000165"(MAPK cascade)|interpro:IPR016024(Armadillo-type fold)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0002011"(morphogenesis of an epithelial sheet)|go:"GO:0003382"(epithelial cell morphogenesis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004706"(JUN kinase kinase kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007254"(JNK cascade)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008432"(JUN kinase binding)|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0016020"(membrane)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0031434"(mitogen-activated protein kinase kinase binding)|go:"GO:0031941"(filamentous actin)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0042060"(wound healing)|go:"GO:0043010"(camera-type eye development)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046625"(sphingolipid binding)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050434"(positive regulation of viral transcription)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0061029"(eyelid development in camera-type eye)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|reactome:R-RNO-166058|reactome:R-RNO-2871796|reactome:R-RNO-975138|reactome:R-RNO-975871|interpro:IPR011989(Armadillo-like helical)|mint:Q62925	refseq:NP_003339.1|dip:DIP-29829N|ensembl:ENSG00000177889(gene)|ensembl:ENST00000318066(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000729"(DNA double-strand break processing)|go:"GO:0001650"(fibrillar center)|go:"GO:0003723"(RNA binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006282"(regulation of DNA repair)|go:"GO:0006301"(postreplication repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016574"(histone ubiquitination)|go:"GO:0031058"(positive regulation of histone modification)|go:"GO:0031372"(UBC13-MMS2 complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033182"(regulation of histone ubiquitination)|go:"GO:0035370"(UBC13-UEV1A complex)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0061631"(ubiquitin conjugating enzyme activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070534"(protein K63-linked ubiquitination)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|interpro:IPR023313|rcsb pdb:1J7D|rcsb pdb:2C2V|rcsb pdb:3HCT|rcsb pdb:3HCU|rcsb pdb:3VON|rcsb pdb:3W31|rcsb pdb:4DHI|rcsb pdb:4DHJ|rcsb pdb:4DHZ|rcsb pdb:4IP3|rcsb pdb:4NR3|rcsb pdb:4NRG|rcsb pdb:4NRI|rcsb pdb:4ONL|rcsb pdb:4ONM|rcsb pdb:4ONN|rcsb pdb:4ORH|rcsb pdb:4TKP|rcsb pdb:4WHV|rcsb pdb:5AIT|rcsb pdb:5AIU|rcsb pdb:5EYA|rcsb pdb:5H7S|rcsb pdb:5VNZ|rcsb pdb:5VO0|rcsb pdb:5YWR|rcsb pdb:6D6I|rcsb pdb:6JKY|rcsb pdb:6KFP|rcsb pdb:6KG6|rcsb pdb:6KL4|rcsb pdb:6LP2|rcsb pdb:6P5B|rcsb pdb:6S53|reactome:R-HSA-168927|reactome:R-HSA-202424|reactome:R-HSA-2871837|reactome:R-HSA-445989|reactome:R-HSA-450302|reactome:R-HSA-450321|reactome:R-HSA-5607764|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-5696395|reactome:R-HSA-69473|reactome:R-HSA-8866654|reactome:R-HSA-9020702|reactome:R-HSA-937039|reactome:R-HSA-937041|reactome:R-HSA-9646399|reactome:R-HSA-975110|reactome:R-HSA-975144|reactome:R-HSA-983168|rcsb pdb:6ULH|rcsb pdb:6UMP|rcsb pdb:6UMS|rcsb pdb:7BBD|rcsb pdb:7BBF|rcsb pdb:7BXG|reactome:R-HSA-1169408|reactome:R-HSA-168638	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S3|resulting-ptm:P61086 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:EwhjYjowkZIAt4UyPcZBUtf9uak10116	rogid:dqdszHlq5FLPHC6UWX6uvkC6Yz89606	intact-crc:FFEDCB014F5A7C68|rigid:0jIh0QbCL9hzkDRznxTOt+f+fBY	false	sufficient binding region:433-481(IPR013083)	his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q62925	uniprotkb:P62255	intact:EBI-636664	intact:EBI-9917192|uniprotkb:Q99462|ensembl:ENSRNOP00000013486	psi-mi:m3k1_rat(display_long)|uniprotkb:MAPK/ERK kinase kinase 1(gene name synonym)|uniprotkb:Map3k1(gene name)|psi-mi:Map3k1(display_short)|uniprotkb:Mekk(gene name synonym)|uniprotkb:Mekk1(gene name synonym)	psi-mi:ub2g1_rat(display_long)|uniprotkb:E217K(gene name synonym)|uniprotkb:UBC7(gene name synonym)|uniprotkb:Ubc7(gene name synonym)|uniprotkb:Ube2g(gene name synonym)|uniprotkb:Ubiquitin carrier protein G1(gene name synonym)|uniprotkb:Ubiquitin-protein ligase G1(gene name synonym)|uniprotkb:Ube2g1(gene name)|psi-mi:Ube2g1(display_short)|uniprotkb:E2 ubiquitin-conjugating enzyme G1(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9971760|imex:IM-22822-84	author-confidence:Z-score = 6.42	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:620966|refseq:NP_446339.1|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR007527(Zinc finger, SWIM-type)|go:"GO:0000165"(MAPK cascade)|interpro:IPR016024(Armadillo-type fold)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0002011"(morphogenesis of an epithelial sheet)|go:"GO:0003382"(epithelial cell morphogenesis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004706"(JUN kinase kinase kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007254"(JNK cascade)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008432"(JUN kinase binding)|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0016020"(membrane)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0031434"(mitogen-activated protein kinase kinase binding)|go:"GO:0031941"(filamentous actin)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0042060"(wound healing)|go:"GO:0043010"(camera-type eye development)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046625"(sphingolipid binding)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050434"(positive regulation of viral transcription)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0061029"(eyelid development in camera-type eye)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|reactome:R-RNO-166058|reactome:R-RNO-2871796|reactome:R-RNO-975138|reactome:R-RNO-975871|interpro:IPR011989(Armadillo-like helical)|mint:Q62925	refseq:NP_073181.1|rgd:620392|ensembl:ENSRNOG00000010041(gene)|ensembl:ENSRNOT00000013486(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0044257"(cellular protein catabolic process)|go:"GO:0061631"(ubiquitin conjugating enzyme activity)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0070936"(protein K48-linked ubiquitination)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|interpro:IPR023313|reactome:R-RNO-8866652|reactome:R-RNO-983168	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S3|resulting-ptm:P62255 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:EwhjYjowkZIAt4UyPcZBUtf9uak10116	rogid:Yw3cuksmoC3miJRlMZhkBGFifso10116	intact-crc:7CC976163B252E29|rigid:2DFVGWWOIJUE1viw3umkVC7XweM	false	sufficient binding region:433-481(IPR013083)	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q62925	uniprotkb:Q13404	intact:EBI-636664	intact:EBI-1050671|uniprotkb:Q13403|uniprotkb:Q13532|uniprotkb:Q96H34|uniprotkb:Q9GZT0|uniprotkb:Q9GZW1|uniprotkb:Q9H4J3|uniprotkb:Q9H4J4|uniprotkb:Q9UKL1|uniprotkb:Q9UM48|uniprotkb:Q9UM49|uniprotkb:Q9UM50|uniprotkb:Q5TGE3|uniprotkb:E1P629|uniprotkb:Q5TGE0|ensembl:ENSP00000360739	psi-mi:m3k1_rat(display_long)|uniprotkb:MAPK/ERK kinase kinase 1(gene name synonym)|uniprotkb:Map3k1(gene name)|psi-mi:Map3k1(display_short)|uniprotkb:Mekk(gene name synonym)|uniprotkb:Mekk1(gene name synonym)	psi-mi:ub2v1_human(display_long)|uniprotkb:CROC-1(gene name synonym)|uniprotkb:TRAF6-regulated IKK activator 1 beta Uev1A(gene name synonym)|uniprotkb:P/OKcl.19(orf name)|uniprotkb:UBE2V1(gene name)|psi-mi:UBE2V1(display_short)|uniprotkb:CROC1(gene name synonym)|uniprotkb:UBE2V(gene name synonym)|uniprotkb:UEV1(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9971760|imex:IM-22822-84	author-confidence:Z-score = 6.42	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:620966|refseq:NP_446339.1|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR007527(Zinc finger, SWIM-type)|go:"GO:0000165"(MAPK cascade)|interpro:IPR016024(Armadillo-type fold)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0002011"(morphogenesis of an epithelial sheet)|go:"GO:0003382"(epithelial cell morphogenesis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004706"(JUN kinase kinase kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007254"(JNK cascade)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008432"(JUN kinase binding)|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0016020"(membrane)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0031434"(mitogen-activated protein kinase kinase binding)|go:"GO:0031941"(filamentous actin)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0042060"(wound healing)|go:"GO:0043010"(camera-type eye development)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046625"(sphingolipid binding)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050434"(positive regulation of viral transcription)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0061029"(eyelid development in camera-type eye)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|reactome:R-RNO-166058|reactome:R-RNO-2871796|reactome:R-RNO-975138|reactome:R-RNO-975871|interpro:IPR011989(Armadillo-like helical)|mint:Q62925	refseq:NP_001027459.1|refseq:NP_068823.2|refseq:NP_071887.1|refseq:NP_954595.1|refseq:NP_954673.1|refseq:NP_001244322.1|refseq:NP_001244323.1|refseq:NP_001244325.1|ensembl:ENSG00000244687(gene)|ensembl:ENST00000371674(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006282"(regulation of DNA repair)|go:"GO:0006301"(postreplication repair)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0030154"(cell differentiation)|go:"GO:0031371"(ubiquitin conjugating enzyme complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035370"(UBC13-UEV1A complex)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070534"(protein K63-linked ubiquitination)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|rcsb pdb:2A4D|rcsb pdb:2C2V|rcsb pdb:2HLW|rcsb pdb:6D6I|reactome:R-HSA-168638|reactome:R-HSA-168927|reactome:R-HSA-202424|reactome:R-HSA-2871837|reactome:R-HSA-445989|reactome:R-HSA-450302|reactome:R-HSA-450321|reactome:R-HSA-5607764|reactome:R-HSA-9020702|reactome:R-HSA-937039|reactome:R-HSA-937041|reactome:R-HSA-9646399|reactome:R-HSA-975110|reactome:R-HSA-975144|reactome:R-HSA-983168|dip:DIP-41911N	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S3|resulting-ptm:P62255 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:EwhjYjowkZIAt4UyPcZBUtf9uak10116	rogid:x95N7Dj2KIqu5gySX59xLmfthUg9606	intact-crc:7CC976163B252E29|rigid:2DFVGWWOIJUE1viw3umkVC7XweM	false	sufficient binding region:433-481(IPR013083)	his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q62925	uniprotkb:P22314	intact:EBI-636664	intact:EBI-709688|uniprotkb:Q96E13|uniprotkb:Q5JRR8|ensembl:ENSP00000338413|ensembl:ENSP00000366568	psi-mi:m3k1_rat(display_long)|uniprotkb:MAPK/ERK kinase kinase 1(gene name synonym)|uniprotkb:Map3k1(gene name)|psi-mi:Map3k1(display_short)|uniprotkb:Mekk(gene name synonym)|uniprotkb:Mekk1(gene name synonym)	psi-mi:uba1_human(display_long)|uniprotkb:Ubiquitin-activating enzyme E1(gene name synonym)|uniprotkb:Protein A1S9(gene name synonym)|uniprotkb:UBA1(gene name)|psi-mi:UBA1(display_short)|uniprotkb:A1S9T(gene name synonym)|uniprotkb:UBE1(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9971760|imex:IM-22822-84	author-confidence:Z-score = 6.42	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:620966|refseq:NP_446339.1|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR007527(Zinc finger, SWIM-type)|go:"GO:0000165"(MAPK cascade)|interpro:IPR016024(Armadillo-type fold)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0002011"(morphogenesis of an epithelial sheet)|go:"GO:0003382"(epithelial cell morphogenesis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004706"(JUN kinase kinase kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007254"(JNK cascade)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008432"(JUN kinase binding)|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0016020"(membrane)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0031434"(mitogen-activated protein kinase kinase binding)|go:"GO:0031941"(filamentous actin)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0042060"(wound healing)|go:"GO:0043010"(camera-type eye development)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046625"(sphingolipid binding)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050434"(positive regulation of viral transcription)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0061029"(eyelid development in camera-type eye)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|reactome:R-RNO-166058|reactome:R-RNO-2871796|reactome:R-RNO-975138|reactome:R-RNO-975871|interpro:IPR011989(Armadillo-like helical)|mint:Q62925	refseq:NP_003325.2|refseq:NP_695012.1|refseq:XP_016885269.1|refseq:XP_016885270.1|dip:DIP-33686N|ensembl:ENSG00000130985(gene)|ensembl:ENST00000335972(transcript)|ensembl:ENST00000377351(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0004839"(ubiquitin activating enzyme activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0032446"(protein modification by small protein conjugation)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000011(Ubiquitin-activating enzyme, E1)|interpro:IPR000594(UBA/THIF-type NAD/FAD binding fold)|interpro:IPR018074|interpro:IPR018075|interpro:IPR018965|interpro:IPR019572|interpro:IPR032418|interpro:IPR032420|interpro:IPR033127|interpro:IPR035985|interpro:IPR038252|interpro:IPR042063|interpro:IPR042302|interpro:IPR042449|mint:P22314|rcsb pdb:4P22|rcsb pdb:6DC6|reactome:R-HSA-8866652|reactome:R-HSA-983168	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S3|resulting-ptm:P62255 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:EwhjYjowkZIAt4UyPcZBUtf9uak10116	rogid:q+vEeA0XLST0Zz173bmEt0dNbDE9606	intact-crc:7CC976163B252E29|rigid:2DFVGWWOIJUE1viw3umkVC7XweM	false	sufficient binding region:433-481(IPR013083)	his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q62925	uniprotkb:P61088	intact:EBI-636664	intact:EBI-1052908|uniprotkb:Q16781|uniprotkb:Q53Y81|ensembl:ENSP00000316176	psi-mi:m3k1_rat(display_long)|uniprotkb:MAPK/ERK kinase kinase 1(gene name synonym)|uniprotkb:Map3k1(gene name)|psi-mi:Map3k1(display_short)|uniprotkb:Mekk(gene name synonym)|uniprotkb:Mekk1(gene name synonym)	psi-mi:ube2n_human(display_long)|uniprotkb:Ubiquitin-protein ligase N(gene name synonym)|uniprotkb:Ubiquitin carrier protein N(gene name synonym)|uniprotkb:Ubc13(gene name synonym)|uniprotkb:Bendless-like ubiquitin-conjugating enzyme(gene name synonym)|uniprotkb:UBE2N(gene name)|psi-mi:UBE2N(display_short)|uniprotkb:BLU(gene name synonym)|uniprotkb:UbcH13(gene name synonym)|uniprotkb:E2 ubiquitin-conjugating enzyme N(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9971760|imex:IM-22822-84	author-confidence:Z-score = 6.42	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:620966|refseq:NP_446339.1|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR007527(Zinc finger, SWIM-type)|go:"GO:0000165"(MAPK cascade)|interpro:IPR016024(Armadillo-type fold)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0002011"(morphogenesis of an epithelial sheet)|go:"GO:0003382"(epithelial cell morphogenesis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004706"(JUN kinase kinase kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007254"(JNK cascade)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008432"(JUN kinase binding)|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0016020"(membrane)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0031434"(mitogen-activated protein kinase kinase binding)|go:"GO:0031941"(filamentous actin)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0042060"(wound healing)|go:"GO:0043010"(camera-type eye development)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046625"(sphingolipid binding)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050434"(positive regulation of viral transcription)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0061029"(eyelid development in camera-type eye)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|reactome:R-RNO-166058|reactome:R-RNO-2871796|reactome:R-RNO-975138|reactome:R-RNO-975871|interpro:IPR011989(Armadillo-like helical)|mint:Q62925	refseq:NP_003339.1|dip:DIP-29829N|ensembl:ENSG00000177889(gene)|ensembl:ENST00000318066(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000729"(DNA double-strand break processing)|go:"GO:0001650"(fibrillar center)|go:"GO:0003723"(RNA binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006282"(regulation of DNA repair)|go:"GO:0006301"(postreplication repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016574"(histone ubiquitination)|go:"GO:0031058"(positive regulation of histone modification)|go:"GO:0031372"(UBC13-MMS2 complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033182"(regulation of histone ubiquitination)|go:"GO:0035370"(UBC13-UEV1A complex)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0061631"(ubiquitin conjugating enzyme activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070534"(protein K63-linked ubiquitination)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|interpro:IPR023313|rcsb pdb:1J7D|rcsb pdb:2C2V|rcsb pdb:3HCT|rcsb pdb:3HCU|rcsb pdb:3VON|rcsb pdb:3W31|rcsb pdb:4DHI|rcsb pdb:4DHJ|rcsb pdb:4DHZ|rcsb pdb:4IP3|rcsb pdb:4NR3|rcsb pdb:4NRG|rcsb pdb:4NRI|rcsb pdb:4ONL|rcsb pdb:4ONM|rcsb pdb:4ONN|rcsb pdb:4ORH|rcsb pdb:4TKP|rcsb pdb:4WHV|rcsb pdb:5AIT|rcsb pdb:5AIU|rcsb pdb:5EYA|rcsb pdb:5H7S|rcsb pdb:5VNZ|rcsb pdb:5VO0|rcsb pdb:5YWR|rcsb pdb:6D6I|rcsb pdb:6JKY|rcsb pdb:6KFP|rcsb pdb:6KG6|rcsb pdb:6KL4|rcsb pdb:6LP2|rcsb pdb:6P5B|rcsb pdb:6S53|reactome:R-HSA-168927|reactome:R-HSA-202424|reactome:R-HSA-2871837|reactome:R-HSA-445989|reactome:R-HSA-450302|reactome:R-HSA-450321|reactome:R-HSA-5607764|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-5696395|reactome:R-HSA-69473|reactome:R-HSA-8866654|reactome:R-HSA-9020702|reactome:R-HSA-937039|reactome:R-HSA-937041|reactome:R-HSA-9646399|reactome:R-HSA-975110|reactome:R-HSA-975144|reactome:R-HSA-983168|rcsb pdb:6ULH|rcsb pdb:6UMP|rcsb pdb:6UMS|rcsb pdb:7BBD|rcsb pdb:7BBF|rcsb pdb:7BXG|reactome:R-HSA-1169408|reactome:R-HSA-168638	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S3|resulting-ptm:P62255 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:EwhjYjowkZIAt4UyPcZBUtf9uak10116	rogid:dqdszHlq5FLPHC6UWX6uvkC6Yz89606	intact-crc:7CC976163B252E29|rigid:2DFVGWWOIJUE1viw3umkVC7XweM	false	sufficient binding region:433-481(IPR013083)	his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q62925	uniprotkb:Q12933	intact:EBI-636664	intact:EBI-355744|uniprotkb:Q96NT2|uniprotkb:A8K107|uniprotkb:B4DPJ7|uniprotkb:Q7Z337|intact:EBI-1046651|ensembl:ENSP00000247668	psi-mi:m3k1_rat(display_long)|uniprotkb:MAPK/ERK kinase kinase 1(gene name synonym)|uniprotkb:Map3k1(gene name)|psi-mi:Map3k1(display_short)|uniprotkb:Mekk(gene name synonym)|uniprotkb:Mekk1(gene name synonym)	psi-mi:traf2_human(display_long)|uniprotkb:TRAF2(gene name)|psi-mi:TRAF2(display_short)|uniprotkb:TRAP3(gene name synonym)|uniprotkb:Tumor necrosis factor type 2 receptor-associated protein 3(gene name synonym)|uniprotkb:E3 ubiquitin-protein ligase TRAF2(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase TRAF2(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9971785|imex:IM-22822-85	author-confidence:Z-score = 10.77	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:620966|refseq:NP_446339.1|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR007527(Zinc finger, SWIM-type)|go:"GO:0000165"(MAPK cascade)|interpro:IPR016024(Armadillo-type fold)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0002011"(morphogenesis of an epithelial sheet)|go:"GO:0003382"(epithelial cell morphogenesis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004706"(JUN kinase kinase kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007254"(JNK cascade)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008432"(JUN kinase binding)|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0016020"(membrane)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0031434"(mitogen-activated protein kinase kinase binding)|go:"GO:0031941"(filamentous actin)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0042060"(wound healing)|go:"GO:0043010"(camera-type eye development)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046625"(sphingolipid binding)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050434"(positive regulation of viral transcription)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0061029"(eyelid development in camera-type eye)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|reactome:R-RNO-166058|reactome:R-RNO-2871796|reactome:R-RNO-975138|reactome:R-RNO-975871|interpro:IPR011989(Armadillo-like helical)|mint:Q62925	refseq:NP_066961.2|refseq:XP_011517279.1|refseq:XP_011517280.1|refseq:XP_011517276.1|refseq:XP_011517277.1|refseq:XP_011517278.1|ensembl:ENSG00000127191(gene)|ensembl:ENST00000247668(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0002637"(regulation of immunoglobulin production)|go:"GO:0002726"(positive regulation of T cell cytokine production)|go:"GO:0002947"(tumor necrosis factor receptor superfamily complex)|go:"GO:0043254"(regulation of protein-containing complex assembly)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046625"(sphingolipid binding)|go:"GO:0048255"(mRNA stabilization)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0071732"(cellular response to nitric oxide)|go:"GO:0097057"(TRAF2-GSTP1 complex)|go:"GO:0097300"(programmed necrotic cell death)|go:"GO:0097400"(interleukin-17-mediated signaling pathway)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1903265"(positive regulation of tumor necrosis factor-mediated signaling pathway)|go:"GO:1903721"(positive regulation of I-kappaB phosphorylation)|go:"GO:1990604"(IRE1-TRAF2-ASK1 complex)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|interpro:IPR001293(Zinc finger, TRAF-type)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR002083(MATH)|interpro:IPR008974(TRAF-like)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005174"(CD40 receptor binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005938"(cell cortex)|go:"GO:0007165"(signal transduction)|go:"GO:0007250"(activation of NF-kappaB-inducing kinase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0012506"(vesicle membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0023019"(signal transduction involved in regulation of gene expression)|go:"GO:0030163"(protein catabolic process)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031435"(mitogen-activated protein kinase kinase kinase binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031996"(thioesterase binding)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034351"(negative regulation of glial cell apoptotic process)|go:"GO:0034622"|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035631"(CD40 receptor complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043120"(tumor necrosis factor binding)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|interpro:IPR012227(TNF receptor-associated factor TRAF)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR018957|interpro:IPR027133|interpro:IPR032070|interpro:IPR037305|interpro:IPR043211|mint:Q12933|rcsb pdb:1CA4|rcsb pdb:1CA9|rcsb pdb:1CZY|rcsb pdb:1CZZ|rcsb pdb:1D00|rcsb pdb:1D01|rcsb pdb:1D0A|rcsb pdb:1D0J|rcsb pdb:1F3V|rcsb pdb:1QSC|rcsb pdb:3KNV|rcsb pdb:3M06|rcsb pdb:3M0A|rcsb pdb:3M0D|reactome:R-HSA-140534|reactome:R-HSA-3371378|reactome:R-HSA-5213460|reactome:R-HSA-5218900|reactome:R-HSA-5357786|reactome:R-HSA-5357905|reactome:R-HSA-5357956|reactome:R-HSA-5668541|reactome:R-HSA-5675482|reactome:R-HSA-5676594|reactome:R-HSA-5689880|reactome:R-HSA-69416|reactome:R-HSA-75893|reactome:R-HSA-933541|reactome:R-HSA-933542|reactome:R-HSA-9693928|refseq:XP_016870584.1|dip:DIP-6223N	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S3|resulting-ptm:Q12933 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:EwhjYjowkZIAt4UyPcZBUtf9uak10116	rogid:JhaoM5kRLh3zwhXr+BsCCRNOYa09606	intact-crc:E6FAB94B3D9F5FF4|rigid:ULDNl8AFPvtSAtsCjZDAeaSHv48	false	sufficient binding region:433-481(IPR013083)	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q62925	uniprotkb:Q13404	intact:EBI-636664	intact:EBI-1050671|uniprotkb:Q13403|uniprotkb:Q13532|uniprotkb:Q96H34|uniprotkb:Q9GZT0|uniprotkb:Q9GZW1|uniprotkb:Q9H4J3|uniprotkb:Q9H4J4|uniprotkb:Q9UKL1|uniprotkb:Q9UM48|uniprotkb:Q9UM49|uniprotkb:Q9UM50|uniprotkb:Q5TGE3|uniprotkb:E1P629|uniprotkb:Q5TGE0|ensembl:ENSP00000360739	psi-mi:m3k1_rat(display_long)|uniprotkb:MAPK/ERK kinase kinase 1(gene name synonym)|uniprotkb:Map3k1(gene name)|psi-mi:Map3k1(display_short)|uniprotkb:Mekk(gene name synonym)|uniprotkb:Mekk1(gene name synonym)	psi-mi:ub2v1_human(display_long)|uniprotkb:CROC-1(gene name synonym)|uniprotkb:TRAF6-regulated IKK activator 1 beta Uev1A(gene name synonym)|uniprotkb:P/OKcl.19(orf name)|uniprotkb:UBE2V1(gene name)|psi-mi:UBE2V1(display_short)|uniprotkb:CROC1(gene name synonym)|uniprotkb:UBE2V(gene name synonym)|uniprotkb:UEV1(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9971785|imex:IM-22822-85	author-confidence:Z-score = 10.77	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:620966|refseq:NP_446339.1|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR007527(Zinc finger, SWIM-type)|go:"GO:0000165"(MAPK cascade)|interpro:IPR016024(Armadillo-type fold)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0002011"(morphogenesis of an epithelial sheet)|go:"GO:0003382"(epithelial cell morphogenesis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004706"(JUN kinase kinase kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007254"(JNK cascade)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008432"(JUN kinase binding)|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0016020"(membrane)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0031434"(mitogen-activated protein kinase kinase binding)|go:"GO:0031941"(filamentous actin)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0042060"(wound healing)|go:"GO:0043010"(camera-type eye development)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046625"(sphingolipid binding)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050434"(positive regulation of viral transcription)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0061029"(eyelid development in camera-type eye)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|reactome:R-RNO-166058|reactome:R-RNO-2871796|reactome:R-RNO-975138|reactome:R-RNO-975871|interpro:IPR011989(Armadillo-like helical)|mint:Q62925	refseq:NP_001027459.1|refseq:NP_068823.2|refseq:NP_071887.1|refseq:NP_954595.1|refseq:NP_954673.1|refseq:NP_001244322.1|refseq:NP_001244323.1|refseq:NP_001244325.1|ensembl:ENSG00000244687(gene)|ensembl:ENST00000371674(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006282"(regulation of DNA repair)|go:"GO:0006301"(postreplication repair)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0030154"(cell differentiation)|go:"GO:0031371"(ubiquitin conjugating enzyme complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035370"(UBC13-UEV1A complex)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070534"(protein K63-linked ubiquitination)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|rcsb pdb:2A4D|rcsb pdb:2C2V|rcsb pdb:2HLW|rcsb pdb:6D6I|reactome:R-HSA-168638|reactome:R-HSA-168927|reactome:R-HSA-202424|reactome:R-HSA-2871837|reactome:R-HSA-445989|reactome:R-HSA-450302|reactome:R-HSA-450321|reactome:R-HSA-5607764|reactome:R-HSA-9020702|reactome:R-HSA-937039|reactome:R-HSA-937041|reactome:R-HSA-9646399|reactome:R-HSA-975110|reactome:R-HSA-975144|reactome:R-HSA-983168|dip:DIP-41911N	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S3|resulting-ptm:Q12933 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:EwhjYjowkZIAt4UyPcZBUtf9uak10116	rogid:x95N7Dj2KIqu5gySX59xLmfthUg9606	intact-crc:E6FAB94B3D9F5FF4|rigid:ULDNl8AFPvtSAtsCjZDAeaSHv48	false	sufficient binding region:433-481(IPR013083)	his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q62925	uniprotkb:P22314	intact:EBI-636664	intact:EBI-709688|uniprotkb:Q96E13|uniprotkb:Q5JRR8|ensembl:ENSP00000338413|ensembl:ENSP00000366568	psi-mi:m3k1_rat(display_long)|uniprotkb:MAPK/ERK kinase kinase 1(gene name synonym)|uniprotkb:Map3k1(gene name)|psi-mi:Map3k1(display_short)|uniprotkb:Mekk(gene name synonym)|uniprotkb:Mekk1(gene name synonym)	psi-mi:uba1_human(display_long)|uniprotkb:Ubiquitin-activating enzyme E1(gene name synonym)|uniprotkb:Protein A1S9(gene name synonym)|uniprotkb:UBA1(gene name)|psi-mi:UBA1(display_short)|uniprotkb:A1S9T(gene name synonym)|uniprotkb:UBE1(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9971785|imex:IM-22822-85	author-confidence:Z-score = 10.77	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:620966|refseq:NP_446339.1|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR007527(Zinc finger, SWIM-type)|go:"GO:0000165"(MAPK cascade)|interpro:IPR016024(Armadillo-type fold)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0002011"(morphogenesis of an epithelial sheet)|go:"GO:0003382"(epithelial cell morphogenesis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004706"(JUN kinase kinase kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007254"(JNK cascade)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008432"(JUN kinase binding)|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0016020"(membrane)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0031434"(mitogen-activated protein kinase kinase binding)|go:"GO:0031941"(filamentous actin)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0042060"(wound healing)|go:"GO:0043010"(camera-type eye development)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046625"(sphingolipid binding)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050434"(positive regulation of viral transcription)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0061029"(eyelid development in camera-type eye)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|reactome:R-RNO-166058|reactome:R-RNO-2871796|reactome:R-RNO-975138|reactome:R-RNO-975871|interpro:IPR011989(Armadillo-like helical)|mint:Q62925	refseq:NP_003325.2|refseq:NP_695012.1|refseq:XP_016885269.1|refseq:XP_016885270.1|dip:DIP-33686N|ensembl:ENSG00000130985(gene)|ensembl:ENST00000335972(transcript)|ensembl:ENST00000377351(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0004839"(ubiquitin activating enzyme activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0032446"(protein modification by small protein conjugation)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000011(Ubiquitin-activating enzyme, E1)|interpro:IPR000594(UBA/THIF-type NAD/FAD binding fold)|interpro:IPR018074|interpro:IPR018075|interpro:IPR018965|interpro:IPR019572|interpro:IPR032418|interpro:IPR032420|interpro:IPR033127|interpro:IPR035985|interpro:IPR038252|interpro:IPR042063|interpro:IPR042302|interpro:IPR042449|mint:P22314|rcsb pdb:4P22|rcsb pdb:6DC6|reactome:R-HSA-8866652|reactome:R-HSA-983168	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S3|resulting-ptm:Q12933 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:EwhjYjowkZIAt4UyPcZBUtf9uak10116	rogid:q+vEeA0XLST0Zz173bmEt0dNbDE9606	intact-crc:E6FAB94B3D9F5FF4|rigid:ULDNl8AFPvtSAtsCjZDAeaSHv48	false	sufficient binding region:433-481(IPR013083)	his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q62925	uniprotkb:P61088	intact:EBI-636664	intact:EBI-1052908|uniprotkb:Q16781|uniprotkb:Q53Y81|ensembl:ENSP00000316176	psi-mi:m3k1_rat(display_long)|uniprotkb:MAPK/ERK kinase kinase 1(gene name synonym)|uniprotkb:Map3k1(gene name)|psi-mi:Map3k1(display_short)|uniprotkb:Mekk(gene name synonym)|uniprotkb:Mekk1(gene name synonym)	psi-mi:ube2n_human(display_long)|uniprotkb:Ubiquitin-protein ligase N(gene name synonym)|uniprotkb:Ubiquitin carrier protein N(gene name synonym)|uniprotkb:Ubc13(gene name synonym)|uniprotkb:Bendless-like ubiquitin-conjugating enzyme(gene name synonym)|uniprotkb:UBE2N(gene name)|psi-mi:UBE2N(display_short)|uniprotkb:BLU(gene name synonym)|uniprotkb:UbcH13(gene name synonym)|uniprotkb:E2 ubiquitin-conjugating enzyme N(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9971785|imex:IM-22822-85	author-confidence:Z-score = 10.77	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:620966|refseq:NP_446339.1|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR007527(Zinc finger, SWIM-type)|go:"GO:0000165"(MAPK cascade)|interpro:IPR016024(Armadillo-type fold)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0002011"(morphogenesis of an epithelial sheet)|go:"GO:0003382"(epithelial cell morphogenesis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004706"(JUN kinase kinase kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007254"(JNK cascade)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008432"(JUN kinase binding)|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0016020"(membrane)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0031434"(mitogen-activated protein kinase kinase binding)|go:"GO:0031941"(filamentous actin)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0042060"(wound healing)|go:"GO:0043010"(camera-type eye development)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046625"(sphingolipid binding)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050434"(positive regulation of viral transcription)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0061029"(eyelid development in camera-type eye)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|reactome:R-RNO-166058|reactome:R-RNO-2871796|reactome:R-RNO-975138|reactome:R-RNO-975871|interpro:IPR011989(Armadillo-like helical)|mint:Q62925	refseq:NP_003339.1|dip:DIP-29829N|ensembl:ENSG00000177889(gene)|ensembl:ENST00000318066(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000729"(DNA double-strand break processing)|go:"GO:0001650"(fibrillar center)|go:"GO:0003723"(RNA binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006282"(regulation of DNA repair)|go:"GO:0006301"(postreplication repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016574"(histone ubiquitination)|go:"GO:0031058"(positive regulation of histone modification)|go:"GO:0031372"(UBC13-MMS2 complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033182"(regulation of histone ubiquitination)|go:"GO:0035370"(UBC13-UEV1A complex)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0061631"(ubiquitin conjugating enzyme activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070534"(protein K63-linked ubiquitination)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|interpro:IPR023313|rcsb pdb:1J7D|rcsb pdb:2C2V|rcsb pdb:3HCT|rcsb pdb:3HCU|rcsb pdb:3VON|rcsb pdb:3W31|rcsb pdb:4DHI|rcsb pdb:4DHJ|rcsb pdb:4DHZ|rcsb pdb:4IP3|rcsb pdb:4NR3|rcsb pdb:4NRG|rcsb pdb:4NRI|rcsb pdb:4ONL|rcsb pdb:4ONM|rcsb pdb:4ONN|rcsb pdb:4ORH|rcsb pdb:4TKP|rcsb pdb:4WHV|rcsb pdb:5AIT|rcsb pdb:5AIU|rcsb pdb:5EYA|rcsb pdb:5H7S|rcsb pdb:5VNZ|rcsb pdb:5VO0|rcsb pdb:5YWR|rcsb pdb:6D6I|rcsb pdb:6JKY|rcsb pdb:6KFP|rcsb pdb:6KG6|rcsb pdb:6KL4|rcsb pdb:6LP2|rcsb pdb:6P5B|rcsb pdb:6S53|reactome:R-HSA-168927|reactome:R-HSA-202424|reactome:R-HSA-2871837|reactome:R-HSA-445989|reactome:R-HSA-450302|reactome:R-HSA-450321|reactome:R-HSA-5607764|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-5696395|reactome:R-HSA-69473|reactome:R-HSA-8866654|reactome:R-HSA-9020702|reactome:R-HSA-937039|reactome:R-HSA-937041|reactome:R-HSA-9646399|reactome:R-HSA-975110|reactome:R-HSA-975144|reactome:R-HSA-983168|rcsb pdb:6ULH|rcsb pdb:6UMP|rcsb pdb:6UMS|rcsb pdb:7BBD|rcsb pdb:7BBF|rcsb pdb:7BXG|reactome:R-HSA-1169408|reactome:R-HSA-168638	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S3|resulting-ptm:Q12933 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:EwhjYjowkZIAt4UyPcZBUtf9uak10116	rogid:dqdszHlq5FLPHC6UWX6uvkC6Yz89606	intact-crc:E6FAB94B3D9F5FF4|rigid:ULDNl8AFPvtSAtsCjZDAeaSHv48	false	sufficient binding region:433-481(IPR013083)	his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q62925	uniprotkb:Q13404	intact:EBI-636664	intact:EBI-1050671|uniprotkb:Q13403|uniprotkb:Q13532|uniprotkb:Q96H34|uniprotkb:Q9GZT0|uniprotkb:Q9GZW1|uniprotkb:Q9H4J3|uniprotkb:Q9H4J4|uniprotkb:Q9UKL1|uniprotkb:Q9UM48|uniprotkb:Q9UM49|uniprotkb:Q9UM50|uniprotkb:Q5TGE3|uniprotkb:E1P629|uniprotkb:Q5TGE0|ensembl:ENSP00000360739	psi-mi:m3k1_rat(display_long)|uniprotkb:MAPK/ERK kinase kinase 1(gene name synonym)|uniprotkb:Map3k1(gene name)|psi-mi:Map3k1(display_short)|uniprotkb:Mekk(gene name synonym)|uniprotkb:Mekk1(gene name synonym)	psi-mi:ub2v1_human(display_long)|uniprotkb:CROC-1(gene name synonym)|uniprotkb:TRAF6-regulated IKK activator 1 beta Uev1A(gene name synonym)|uniprotkb:P/OKcl.19(orf name)|uniprotkb:UBE2V1(gene name)|psi-mi:UBE2V1(display_short)|uniprotkb:CROC1(gene name synonym)|uniprotkb:UBE2V(gene name synonym)|uniprotkb:UEV1(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9971810|imex:IM-22822-86	author-confidence:Z-score = 10.77	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:620966|refseq:NP_446339.1|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR007527(Zinc finger, SWIM-type)|go:"GO:0000165"(MAPK cascade)|interpro:IPR016024(Armadillo-type fold)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0002011"(morphogenesis of an epithelial sheet)|go:"GO:0003382"(epithelial cell morphogenesis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004706"(JUN kinase kinase kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007254"(JNK cascade)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008432"(JUN kinase binding)|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0016020"(membrane)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0031434"(mitogen-activated protein kinase kinase binding)|go:"GO:0031941"(filamentous actin)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0042060"(wound healing)|go:"GO:0043010"(camera-type eye development)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046625"(sphingolipid binding)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050434"(positive regulation of viral transcription)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0061029"(eyelid development in camera-type eye)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|reactome:R-RNO-166058|reactome:R-RNO-2871796|reactome:R-RNO-975138|reactome:R-RNO-975871|interpro:IPR011989(Armadillo-like helical)|mint:Q62925	refseq:NP_001027459.1|refseq:NP_068823.2|refseq:NP_071887.1|refseq:NP_954595.1|refseq:NP_954673.1|refseq:NP_001244322.1|refseq:NP_001244323.1|refseq:NP_001244325.1|ensembl:ENSG00000244687(gene)|ensembl:ENST00000371674(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006282"(regulation of DNA repair)|go:"GO:0006301"(postreplication repair)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0030154"(cell differentiation)|go:"GO:0031371"(ubiquitin conjugating enzyme complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035370"(UBC13-UEV1A complex)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070534"(protein K63-linked ubiquitination)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|rcsb pdb:2A4D|rcsb pdb:2C2V|rcsb pdb:2HLW|rcsb pdb:6D6I|reactome:R-HSA-168638|reactome:R-HSA-168927|reactome:R-HSA-202424|reactome:R-HSA-2871837|reactome:R-HSA-445989|reactome:R-HSA-450302|reactome:R-HSA-450321|reactome:R-HSA-5607764|reactome:R-HSA-9020702|reactome:R-HSA-937039|reactome:R-HSA-937041|reactome:R-HSA-9646399|reactome:R-HSA-975110|reactome:R-HSA-975144|reactome:R-HSA-983168|dip:DIP-41911N	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S3|resulting-ptm:Q13404 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:EwhjYjowkZIAt4UyPcZBUtf9uak10116	rogid:x95N7Dj2KIqu5gySX59xLmfthUg9606	intact-crc:C16982A86694F88A|rigid:7NavsnSZbqlAXRAYtUFEf3bdsII	false	sufficient binding region:433-481(IPR013083)	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q62925	uniprotkb:Q13404	intact:EBI-636664	intact:EBI-1050671|uniprotkb:Q13403|uniprotkb:Q13532|uniprotkb:Q96H34|uniprotkb:Q9GZT0|uniprotkb:Q9GZW1|uniprotkb:Q9H4J3|uniprotkb:Q9H4J4|uniprotkb:Q9UKL1|uniprotkb:Q9UM48|uniprotkb:Q9UM49|uniprotkb:Q9UM50|uniprotkb:Q5TGE3|uniprotkb:E1P629|uniprotkb:Q5TGE0|ensembl:ENSP00000360739	psi-mi:m3k1_rat(display_long)|uniprotkb:MAPK/ERK kinase kinase 1(gene name synonym)|uniprotkb:Map3k1(gene name)|psi-mi:Map3k1(display_short)|uniprotkb:Mekk(gene name synonym)|uniprotkb:Mekk1(gene name synonym)	psi-mi:ub2v1_human(display_long)|uniprotkb:CROC-1(gene name synonym)|uniprotkb:TRAF6-regulated IKK activator 1 beta Uev1A(gene name synonym)|uniprotkb:P/OKcl.19(orf name)|uniprotkb:UBE2V1(gene name)|psi-mi:UBE2V1(display_short)|uniprotkb:CROC1(gene name synonym)|uniprotkb:UBE2V(gene name synonym)|uniprotkb:UEV1(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9971810|imex:IM-22822-86	author-confidence:Z-score = 10.77	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:620966|refseq:NP_446339.1|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR007527(Zinc finger, SWIM-type)|go:"GO:0000165"(MAPK cascade)|interpro:IPR016024(Armadillo-type fold)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0002011"(morphogenesis of an epithelial sheet)|go:"GO:0003382"(epithelial cell morphogenesis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004706"(JUN kinase kinase kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007254"(JNK cascade)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008432"(JUN kinase binding)|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0016020"(membrane)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0031434"(mitogen-activated protein kinase kinase binding)|go:"GO:0031941"(filamentous actin)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0042060"(wound healing)|go:"GO:0043010"(camera-type eye development)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046625"(sphingolipid binding)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050434"(positive regulation of viral transcription)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0061029"(eyelid development in camera-type eye)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|reactome:R-RNO-166058|reactome:R-RNO-2871796|reactome:R-RNO-975138|reactome:R-RNO-975871|interpro:IPR011989(Armadillo-like helical)|mint:Q62925	refseq:NP_001027459.1|refseq:NP_068823.2|refseq:NP_071887.1|refseq:NP_954595.1|refseq:NP_954673.1|refseq:NP_001244322.1|refseq:NP_001244323.1|refseq:NP_001244325.1|ensembl:ENSG00000244687(gene)|ensembl:ENST00000371674(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006282"(regulation of DNA repair)|go:"GO:0006301"(postreplication repair)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0030154"(cell differentiation)|go:"GO:0031371"(ubiquitin conjugating enzyme complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035370"(UBC13-UEV1A complex)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070534"(protein K63-linked ubiquitination)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|rcsb pdb:2A4D|rcsb pdb:2C2V|rcsb pdb:2HLW|rcsb pdb:6D6I|reactome:R-HSA-168638|reactome:R-HSA-168927|reactome:R-HSA-202424|reactome:R-HSA-2871837|reactome:R-HSA-445989|reactome:R-HSA-450302|reactome:R-HSA-450321|reactome:R-HSA-5607764|reactome:R-HSA-9020702|reactome:R-HSA-937039|reactome:R-HSA-937041|reactome:R-HSA-9646399|reactome:R-HSA-975110|reactome:R-HSA-975144|reactome:R-HSA-983168|dip:DIP-41911N	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S3|resulting-ptm:Q13404 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:EwhjYjowkZIAt4UyPcZBUtf9uak10116	rogid:x95N7Dj2KIqu5gySX59xLmfthUg9606	intact-crc:C16982A86694F88A|rigid:7NavsnSZbqlAXRAYtUFEf3bdsII	false	sufficient binding region:433-481(IPR013083)	his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q62925	uniprotkb:P22314	intact:EBI-636664	intact:EBI-709688|uniprotkb:Q96E13|uniprotkb:Q5JRR8|ensembl:ENSP00000338413|ensembl:ENSP00000366568	psi-mi:m3k1_rat(display_long)|uniprotkb:MAPK/ERK kinase kinase 1(gene name synonym)|uniprotkb:Map3k1(gene name)|psi-mi:Map3k1(display_short)|uniprotkb:Mekk(gene name synonym)|uniprotkb:Mekk1(gene name synonym)	psi-mi:uba1_human(display_long)|uniprotkb:Ubiquitin-activating enzyme E1(gene name synonym)|uniprotkb:Protein A1S9(gene name synonym)|uniprotkb:UBA1(gene name)|psi-mi:UBA1(display_short)|uniprotkb:A1S9T(gene name synonym)|uniprotkb:UBE1(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9971810|imex:IM-22822-86	author-confidence:Z-score = 10.77	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:620966|refseq:NP_446339.1|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR007527(Zinc finger, SWIM-type)|go:"GO:0000165"(MAPK cascade)|interpro:IPR016024(Armadillo-type fold)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0002011"(morphogenesis of an epithelial sheet)|go:"GO:0003382"(epithelial cell morphogenesis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004706"(JUN kinase kinase kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007254"(JNK cascade)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008432"(JUN kinase binding)|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0016020"(membrane)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0031434"(mitogen-activated protein kinase kinase binding)|go:"GO:0031941"(filamentous actin)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0042060"(wound healing)|go:"GO:0043010"(camera-type eye development)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046625"(sphingolipid binding)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050434"(positive regulation of viral transcription)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0061029"(eyelid development in camera-type eye)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|reactome:R-RNO-166058|reactome:R-RNO-2871796|reactome:R-RNO-975138|reactome:R-RNO-975871|interpro:IPR011989(Armadillo-like helical)|mint:Q62925	refseq:NP_003325.2|refseq:NP_695012.1|refseq:XP_016885269.1|refseq:XP_016885270.1|dip:DIP-33686N|ensembl:ENSG00000130985(gene)|ensembl:ENST00000335972(transcript)|ensembl:ENST00000377351(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0004839"(ubiquitin activating enzyme activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0032446"(protein modification by small protein conjugation)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000011(Ubiquitin-activating enzyme, E1)|interpro:IPR000594(UBA/THIF-type NAD/FAD binding fold)|interpro:IPR018074|interpro:IPR018075|interpro:IPR018965|interpro:IPR019572|interpro:IPR032418|interpro:IPR032420|interpro:IPR033127|interpro:IPR035985|interpro:IPR038252|interpro:IPR042063|interpro:IPR042302|interpro:IPR042449|mint:P22314|rcsb pdb:4P22|rcsb pdb:6DC6|reactome:R-HSA-8866652|reactome:R-HSA-983168	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S3|resulting-ptm:Q13404 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:EwhjYjowkZIAt4UyPcZBUtf9uak10116	rogid:q+vEeA0XLST0Zz173bmEt0dNbDE9606	intact-crc:C16982A86694F88A|rigid:7NavsnSZbqlAXRAYtUFEf3bdsII	false	sufficient binding region:433-481(IPR013083)	his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q62925	uniprotkb:P61088	intact:EBI-636664	intact:EBI-1052908|uniprotkb:Q16781|uniprotkb:Q53Y81|ensembl:ENSP00000316176	psi-mi:m3k1_rat(display_long)|uniprotkb:MAPK/ERK kinase kinase 1(gene name synonym)|uniprotkb:Map3k1(gene name)|psi-mi:Map3k1(display_short)|uniprotkb:Mekk(gene name synonym)|uniprotkb:Mekk1(gene name synonym)	psi-mi:ube2n_human(display_long)|uniprotkb:Ubiquitin-protein ligase N(gene name synonym)|uniprotkb:Ubiquitin carrier protein N(gene name synonym)|uniprotkb:Ubc13(gene name synonym)|uniprotkb:Bendless-like ubiquitin-conjugating enzyme(gene name synonym)|uniprotkb:UBE2N(gene name)|psi-mi:UBE2N(display_short)|uniprotkb:BLU(gene name synonym)|uniprotkb:UbcH13(gene name synonym)|uniprotkb:E2 ubiquitin-conjugating enzyme N(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9971810|imex:IM-22822-86	author-confidence:Z-score = 10.77	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:620966|refseq:NP_446339.1|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR007527(Zinc finger, SWIM-type)|go:"GO:0000165"(MAPK cascade)|interpro:IPR016024(Armadillo-type fold)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0002011"(morphogenesis of an epithelial sheet)|go:"GO:0003382"(epithelial cell morphogenesis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004706"(JUN kinase kinase kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007254"(JNK cascade)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008432"(JUN kinase binding)|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0016020"(membrane)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0031434"(mitogen-activated protein kinase kinase binding)|go:"GO:0031941"(filamentous actin)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0042060"(wound healing)|go:"GO:0043010"(camera-type eye development)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046625"(sphingolipid binding)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050434"(positive regulation of viral transcription)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0061029"(eyelid development in camera-type eye)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|reactome:R-RNO-166058|reactome:R-RNO-2871796|reactome:R-RNO-975138|reactome:R-RNO-975871|interpro:IPR011989(Armadillo-like helical)|mint:Q62925	refseq:NP_003339.1|dip:DIP-29829N|ensembl:ENSG00000177889(gene)|ensembl:ENST00000318066(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000729"(DNA double-strand break processing)|go:"GO:0001650"(fibrillar center)|go:"GO:0003723"(RNA binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006282"(regulation of DNA repair)|go:"GO:0006301"(postreplication repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016574"(histone ubiquitination)|go:"GO:0031058"(positive regulation of histone modification)|go:"GO:0031372"(UBC13-MMS2 complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033182"(regulation of histone ubiquitination)|go:"GO:0035370"(UBC13-UEV1A complex)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0061631"(ubiquitin conjugating enzyme activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070534"(protein K63-linked ubiquitination)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|interpro:IPR023313|rcsb pdb:1J7D|rcsb pdb:2C2V|rcsb pdb:3HCT|rcsb pdb:3HCU|rcsb pdb:3VON|rcsb pdb:3W31|rcsb pdb:4DHI|rcsb pdb:4DHJ|rcsb pdb:4DHZ|rcsb pdb:4IP3|rcsb pdb:4NR3|rcsb pdb:4NRG|rcsb pdb:4NRI|rcsb pdb:4ONL|rcsb pdb:4ONM|rcsb pdb:4ONN|rcsb pdb:4ORH|rcsb pdb:4TKP|rcsb pdb:4WHV|rcsb pdb:5AIT|rcsb pdb:5AIU|rcsb pdb:5EYA|rcsb pdb:5H7S|rcsb pdb:5VNZ|rcsb pdb:5VO0|rcsb pdb:5YWR|rcsb pdb:6D6I|rcsb pdb:6JKY|rcsb pdb:6KFP|rcsb pdb:6KG6|rcsb pdb:6KL4|rcsb pdb:6LP2|rcsb pdb:6P5B|rcsb pdb:6S53|reactome:R-HSA-168927|reactome:R-HSA-202424|reactome:R-HSA-2871837|reactome:R-HSA-445989|reactome:R-HSA-450302|reactome:R-HSA-450321|reactome:R-HSA-5607764|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-5696395|reactome:R-HSA-69473|reactome:R-HSA-8866654|reactome:R-HSA-9020702|reactome:R-HSA-937039|reactome:R-HSA-937041|reactome:R-HSA-9646399|reactome:R-HSA-975110|reactome:R-HSA-975144|reactome:R-HSA-983168|rcsb pdb:6ULH|rcsb pdb:6UMP|rcsb pdb:6UMS|rcsb pdb:7BBD|rcsb pdb:7BBF|rcsb pdb:7BXG|reactome:R-HSA-1169408|reactome:R-HSA-168638	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S3|resulting-ptm:Q13404 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:EwhjYjowkZIAt4UyPcZBUtf9uak10116	rogid:dqdszHlq5FLPHC6UWX6uvkC6Yz89606	intact-crc:C16982A86694F88A|rigid:7NavsnSZbqlAXRAYtUFEf3bdsII	false	sufficient binding region:433-481(IPR013083)	his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q62925	uniprotkb:Q13501	intact:EBI-636664	intact:EBI-307104|uniprotkb:Q13446|uniprotkb:Q9BUV7|uniprotkb:Q9BVS6|uniprotkb:Q9UEU1|uniprotkb:A6NFN7|uniprotkb:B2R661|uniprotkb:B3KUW5|intact:EBI-28976133|ensembl:ENSP00000374455	psi-mi:m3k1_rat(display_long)|uniprotkb:MAPK/ERK kinase kinase 1(gene name synonym)|uniprotkb:Map3k1(gene name)|psi-mi:Map3k1(display_short)|uniprotkb:Mekk(gene name synonym)|uniprotkb:Mekk1(gene name synonym)	psi-mi:sqstm_human(display_long)|uniprotkb:SQSTM1(gene name)|psi-mi:SQSTM1(display_short)|uniprotkb:ORCA(gene name synonym)|uniprotkb:OSIL(gene name synonym)|uniprotkb:Phosphotyrosine-independent ligand for the Lck SH2 domain of 62 kDa(gene name synonym)|uniprotkb:Ubiquitin-binding protein p62(gene name synonym)|uniprotkb:EBI3-associated protein of 60 kDa(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9971835|imex:IM-22822-87	author-confidence:Z-score = 8.23|author-confidence:Z-score = 10.77	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:620966|refseq:NP_446339.1|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR007527(Zinc finger, SWIM-type)|go:"GO:0000165"(MAPK cascade)|interpro:IPR016024(Armadillo-type fold)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0002011"(morphogenesis of an epithelial sheet)|go:"GO:0003382"(epithelial cell morphogenesis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004706"(JUN kinase kinase kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007254"(JNK cascade)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008432"(JUN kinase binding)|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0016020"(membrane)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0031434"(mitogen-activated protein kinase kinase binding)|go:"GO:0031941"(filamentous actin)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0042060"(wound healing)|go:"GO:0043010"(camera-type eye development)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046625"(sphingolipid binding)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050434"(positive regulation of viral transcription)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0061029"(eyelid development in camera-type eye)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|reactome:R-RNO-166058|reactome:R-RNO-2871796|reactome:R-RNO-975138|reactome:R-RNO-975871|interpro:IPR011989(Armadillo-like helical)|mint:Q62925	ensembl:ENST00000360718|ensembl:ENSP00000353944|ensembl:ENSP00000374455|ensembl:ENSG00000161011(gene)|ensembl:ENST00000389805(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000407"(phagophore assembly site)|go:"GO:0000422"(autophagy of mitochondrion)|go:"GO:0000423"(mitophagy)|go:"GO:0000932"(P-body)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002376"(immune system process)|go:"GO:0002931"(response to ischemia)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005770"(late endosome)|go:"GO:0005776"(autophagosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006914"(autophagy)|go:"GO:0006915"(apoptotic process)|go:"GO:0007032"(endosome organization)|go:"GO:0008104"(protein localization)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010821"(regulation of mitochondrion organization)|go:"GO:0016197"(endosomal transport)|go:"GO:0016234"(inclusion body)|go:"GO:0016235"(aggresome)|go:"GO:0016236"(macroautophagy)|go:"GO:0016605"(PML body)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030154"(cell differentiation)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035973"(aggrephagy)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046578"(regulation of Ras protein signal transduction)|go:"GO:0061635"(regulation of protein complex stability)|go:"GO:0061912"(selective autophagy)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070530"(K63-linked polyubiquitin modification-dependent protein binding)|go:"GO:0097225"(sperm midpiece)|go:"GO:0097413"(Lewy body)|go:"GO:0098780"(response to mitochondrial depolarisation)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1905719"(protein localization to perinuclear region of cytoplasm)|interpro:IPR000270(Octicosapeptide/Phox/Bem1p)|interpro:IPR000433(Zinc finger, ZZ-type)|interpro:IPR009060(UBA-like)|go:"GO:0043130"(ubiquitin binding)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|go:"GO:0043231"(intracellular membrane-bounded organelle)|interpro:IPR033741|go:"GO:0044753"(amphisome)|interpro:IPR034866|interpro:IPR043145|mint:Q13501|rcsb pdb:1Q02|rcsb pdb:2JY7|rcsb pdb:2JY8|rcsb pdb:2K0B|rcsb pdb:2KNV|go:"GO:0044754"(autolysosome)|rcsb pdb:4MJS|rcsb pdb:4UF8|rcsb pdb:4UF9|go:"GO:0044877"(protein-containing complex binding)|rcsb pdb:5YP7|rcsb pdb:5YP8|rcsb pdb:5YPA|rcsb pdb:5YPB|rcsb pdb:5YPC|rcsb pdb:5YPE|rcsb pdb:5YPF|rcsb pdb:5YPG|rcsb pdb:5YPH|rcsb pdb:6JM4|rcsb pdb:6KHZ|rcsb pdb:6MJ7|rcsb pdb:6TGY|rcsb pdb:6TH3|reactome:R-HSA-205043|reactome:R-HSA-209543|reactome:R-HSA-209560|reactome:R-HSA-5205685|reactome:R-HSA-9020702|reactome:R-HSA-9664873|refseq:NP_001135770.1|refseq:NP_001135771.1|refseq:NP_003891.1|dip:DIP-34443N|refseq:XP_016865499.1	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S3|resulting-ptm:Q13501 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:EwhjYjowkZIAt4UyPcZBUtf9uak10116	rogid:paIcBLmyiv1+D9QMym5MY3yc8MI9606	intact-crc:F64159DA04F75F77|rigid:9rrnm+y2oey/5amEjqaJreKIqow	false	sufficient binding region:433-481(IPR013083)	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q62925	uniprotkb:Q13404	intact:EBI-636664	intact:EBI-1050671|uniprotkb:Q13403|uniprotkb:Q13532|uniprotkb:Q96H34|uniprotkb:Q9GZT0|uniprotkb:Q9GZW1|uniprotkb:Q9H4J3|uniprotkb:Q9H4J4|uniprotkb:Q9UKL1|uniprotkb:Q9UM48|uniprotkb:Q9UM49|uniprotkb:Q9UM50|uniprotkb:Q5TGE3|uniprotkb:E1P629|uniprotkb:Q5TGE0|ensembl:ENSP00000360739	psi-mi:m3k1_rat(display_long)|uniprotkb:MAPK/ERK kinase kinase 1(gene name synonym)|uniprotkb:Map3k1(gene name)|psi-mi:Map3k1(display_short)|uniprotkb:Mekk(gene name synonym)|uniprotkb:Mekk1(gene name synonym)	psi-mi:ub2v1_human(display_long)|uniprotkb:CROC-1(gene name synonym)|uniprotkb:TRAF6-regulated IKK activator 1 beta Uev1A(gene name synonym)|uniprotkb:P/OKcl.19(orf name)|uniprotkb:UBE2V1(gene name)|psi-mi:UBE2V1(display_short)|uniprotkb:CROC1(gene name synonym)|uniprotkb:UBE2V(gene name synonym)|uniprotkb:UEV1(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9971835|imex:IM-22822-87	author-confidence:Z-score = 8.23|author-confidence:Z-score = 10.77	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:620966|refseq:NP_446339.1|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR007527(Zinc finger, SWIM-type)|go:"GO:0000165"(MAPK cascade)|interpro:IPR016024(Armadillo-type fold)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0002011"(morphogenesis of an epithelial sheet)|go:"GO:0003382"(epithelial cell morphogenesis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004706"(JUN kinase kinase kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007254"(JNK cascade)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008432"(JUN kinase binding)|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0016020"(membrane)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0031434"(mitogen-activated protein kinase kinase binding)|go:"GO:0031941"(filamentous actin)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0042060"(wound healing)|go:"GO:0043010"(camera-type eye development)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046625"(sphingolipid binding)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050434"(positive regulation of viral transcription)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0061029"(eyelid development in camera-type eye)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|reactome:R-RNO-166058|reactome:R-RNO-2871796|reactome:R-RNO-975138|reactome:R-RNO-975871|interpro:IPR011989(Armadillo-like helical)|mint:Q62925	refseq:NP_001027459.1|refseq:NP_068823.2|refseq:NP_071887.1|refseq:NP_954595.1|refseq:NP_954673.1|refseq:NP_001244322.1|refseq:NP_001244323.1|refseq:NP_001244325.1|ensembl:ENSG00000244687(gene)|ensembl:ENST00000371674(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006282"(regulation of DNA repair)|go:"GO:0006301"(postreplication repair)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0030154"(cell differentiation)|go:"GO:0031371"(ubiquitin conjugating enzyme complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035370"(UBC13-UEV1A complex)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070534"(protein K63-linked ubiquitination)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|rcsb pdb:2A4D|rcsb pdb:2C2V|rcsb pdb:2HLW|rcsb pdb:6D6I|reactome:R-HSA-168638|reactome:R-HSA-168927|reactome:R-HSA-202424|reactome:R-HSA-2871837|reactome:R-HSA-445989|reactome:R-HSA-450302|reactome:R-HSA-450321|reactome:R-HSA-5607764|reactome:R-HSA-9020702|reactome:R-HSA-937039|reactome:R-HSA-937041|reactome:R-HSA-9646399|reactome:R-HSA-975110|reactome:R-HSA-975144|reactome:R-HSA-983168|dip:DIP-41911N	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S3|resulting-ptm:Q13501 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:EwhjYjowkZIAt4UyPcZBUtf9uak10116	rogid:x95N7Dj2KIqu5gySX59xLmfthUg9606	intact-crc:F64159DA04F75F77|rigid:9rrnm+y2oey/5amEjqaJreKIqow	false	sufficient binding region:433-481(IPR013083)	his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q62925	uniprotkb:P22314	intact:EBI-636664	intact:EBI-709688|uniprotkb:Q96E13|uniprotkb:Q5JRR8|ensembl:ENSP00000338413|ensembl:ENSP00000366568	psi-mi:m3k1_rat(display_long)|uniprotkb:MAPK/ERK kinase kinase 1(gene name synonym)|uniprotkb:Map3k1(gene name)|psi-mi:Map3k1(display_short)|uniprotkb:Mekk(gene name synonym)|uniprotkb:Mekk1(gene name synonym)	psi-mi:uba1_human(display_long)|uniprotkb:Ubiquitin-activating enzyme E1(gene name synonym)|uniprotkb:Protein A1S9(gene name synonym)|uniprotkb:UBA1(gene name)|psi-mi:UBA1(display_short)|uniprotkb:A1S9T(gene name synonym)|uniprotkb:UBE1(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9971835|imex:IM-22822-87	author-confidence:Z-score = 8.23|author-confidence:Z-score = 10.77	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:620966|refseq:NP_446339.1|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR007527(Zinc finger, SWIM-type)|go:"GO:0000165"(MAPK cascade)|interpro:IPR016024(Armadillo-type fold)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0002011"(morphogenesis of an epithelial sheet)|go:"GO:0003382"(epithelial cell morphogenesis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004706"(JUN kinase kinase kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007254"(JNK cascade)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008432"(JUN kinase binding)|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0016020"(membrane)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0031434"(mitogen-activated protein kinase kinase binding)|go:"GO:0031941"(filamentous actin)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0042060"(wound healing)|go:"GO:0043010"(camera-type eye development)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046625"(sphingolipid binding)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050434"(positive regulation of viral transcription)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0061029"(eyelid development in camera-type eye)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|reactome:R-RNO-166058|reactome:R-RNO-2871796|reactome:R-RNO-975138|reactome:R-RNO-975871|interpro:IPR011989(Armadillo-like helical)|mint:Q62925	refseq:NP_003325.2|refseq:NP_695012.1|refseq:XP_016885269.1|refseq:XP_016885270.1|dip:DIP-33686N|ensembl:ENSG00000130985(gene)|ensembl:ENST00000335972(transcript)|ensembl:ENST00000377351(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0004839"(ubiquitin activating enzyme activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0032446"(protein modification by small protein conjugation)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000011(Ubiquitin-activating enzyme, E1)|interpro:IPR000594(UBA/THIF-type NAD/FAD binding fold)|interpro:IPR018074|interpro:IPR018075|interpro:IPR018965|interpro:IPR019572|interpro:IPR032418|interpro:IPR032420|interpro:IPR033127|interpro:IPR035985|interpro:IPR038252|interpro:IPR042063|interpro:IPR042302|interpro:IPR042449|mint:P22314|rcsb pdb:4P22|rcsb pdb:6DC6|reactome:R-HSA-8866652|reactome:R-HSA-983168	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S3|resulting-ptm:Q13501 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:EwhjYjowkZIAt4UyPcZBUtf9uak10116	rogid:q+vEeA0XLST0Zz173bmEt0dNbDE9606	intact-crc:F64159DA04F75F77|rigid:9rrnm+y2oey/5amEjqaJreKIqow	false	sufficient binding region:433-481(IPR013083)	his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q62925	uniprotkb:P61088	intact:EBI-636664	intact:EBI-1052908|uniprotkb:Q16781|uniprotkb:Q53Y81|ensembl:ENSP00000316176	psi-mi:m3k1_rat(display_long)|uniprotkb:MAPK/ERK kinase kinase 1(gene name synonym)|uniprotkb:Map3k1(gene name)|psi-mi:Map3k1(display_short)|uniprotkb:Mekk(gene name synonym)|uniprotkb:Mekk1(gene name synonym)	psi-mi:ube2n_human(display_long)|uniprotkb:Ubiquitin-protein ligase N(gene name synonym)|uniprotkb:Ubiquitin carrier protein N(gene name synonym)|uniprotkb:Ubc13(gene name synonym)|uniprotkb:Bendless-like ubiquitin-conjugating enzyme(gene name synonym)|uniprotkb:UBE2N(gene name)|psi-mi:UBE2N(display_short)|uniprotkb:BLU(gene name synonym)|uniprotkb:UbcH13(gene name synonym)|uniprotkb:E2 ubiquitin-conjugating enzyme N(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9971835|imex:IM-22822-87	author-confidence:Z-score = 8.23|author-confidence:Z-score = 10.77	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:620966|refseq:NP_446339.1|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR007527(Zinc finger, SWIM-type)|go:"GO:0000165"(MAPK cascade)|interpro:IPR016024(Armadillo-type fold)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0002011"(morphogenesis of an epithelial sheet)|go:"GO:0003382"(epithelial cell morphogenesis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004706"(JUN kinase kinase kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007254"(JNK cascade)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008432"(JUN kinase binding)|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0016020"(membrane)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0031434"(mitogen-activated protein kinase kinase binding)|go:"GO:0031941"(filamentous actin)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0042060"(wound healing)|go:"GO:0043010"(camera-type eye development)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046625"(sphingolipid binding)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050434"(positive regulation of viral transcription)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0061029"(eyelid development in camera-type eye)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|reactome:R-RNO-166058|reactome:R-RNO-2871796|reactome:R-RNO-975138|reactome:R-RNO-975871|interpro:IPR011989(Armadillo-like helical)|mint:Q62925	refseq:NP_003339.1|dip:DIP-29829N|ensembl:ENSG00000177889(gene)|ensembl:ENST00000318066(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000729"(DNA double-strand break processing)|go:"GO:0001650"(fibrillar center)|go:"GO:0003723"(RNA binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006282"(regulation of DNA repair)|go:"GO:0006301"(postreplication repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016574"(histone ubiquitination)|go:"GO:0031058"(positive regulation of histone modification)|go:"GO:0031372"(UBC13-MMS2 complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033182"(regulation of histone ubiquitination)|go:"GO:0035370"(UBC13-UEV1A complex)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0061631"(ubiquitin conjugating enzyme activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070534"(protein K63-linked ubiquitination)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|interpro:IPR023313|rcsb pdb:1J7D|rcsb pdb:2C2V|rcsb pdb:3HCT|rcsb pdb:3HCU|rcsb pdb:3VON|rcsb pdb:3W31|rcsb pdb:4DHI|rcsb pdb:4DHJ|rcsb pdb:4DHZ|rcsb pdb:4IP3|rcsb pdb:4NR3|rcsb pdb:4NRG|rcsb pdb:4NRI|rcsb pdb:4ONL|rcsb pdb:4ONM|rcsb pdb:4ONN|rcsb pdb:4ORH|rcsb pdb:4TKP|rcsb pdb:4WHV|rcsb pdb:5AIT|rcsb pdb:5AIU|rcsb pdb:5EYA|rcsb pdb:5H7S|rcsb pdb:5VNZ|rcsb pdb:5VO0|rcsb pdb:5YWR|rcsb pdb:6D6I|rcsb pdb:6JKY|rcsb pdb:6KFP|rcsb pdb:6KG6|rcsb pdb:6KL4|rcsb pdb:6LP2|rcsb pdb:6P5B|rcsb pdb:6S53|reactome:R-HSA-168927|reactome:R-HSA-202424|reactome:R-HSA-2871837|reactome:R-HSA-445989|reactome:R-HSA-450302|reactome:R-HSA-450321|reactome:R-HSA-5607764|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-5696395|reactome:R-HSA-69473|reactome:R-HSA-8866654|reactome:R-HSA-9020702|reactome:R-HSA-937039|reactome:R-HSA-937041|reactome:R-HSA-9646399|reactome:R-HSA-975110|reactome:R-HSA-975144|reactome:R-HSA-983168|rcsb pdb:6ULH|rcsb pdb:6UMP|rcsb pdb:6UMS|rcsb pdb:7BBD|rcsb pdb:7BBF|rcsb pdb:7BXG|reactome:R-HSA-1169408|reactome:R-HSA-168638	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S3|resulting-ptm:Q13501 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:EwhjYjowkZIAt4UyPcZBUtf9uak10116	rogid:dqdszHlq5FLPHC6UWX6uvkC6Yz89606	intact-crc:F64159DA04F75F77|rigid:9rrnm+y2oey/5amEjqaJreKIqow	false	sufficient binding region:433-481(IPR013083)	his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q62925	uniprotkb:Q15025	intact:EBI-636664	intact:EBI-357849|uniprotkb:A4F1W8|uniprotkb:O76008|uniprotkb:Q96EL9|uniprotkb:Q99833|uniprotkb:Q9H1J3|uniprotkb:B7Z699|uniprotkb:Q6N077|ensembl:ENSP00000317891|ensembl:ENSP00000428187|ensembl:ENSP00000430760|uniprotkb:A4F1W9|uniprotkb:A4F1X2|uniprotkb:A4F1X4|uniprotkb:A4F1X5|uniprotkb:A4F1X6|uniprotkb:A4F1X7|uniprotkb:A4F1X9|uniprotkb:E7EPY1|uniprotkb:E7ET96|uniprotkb:Q05KP3|uniprotkb:Q05KP4	psi-mi:m3k1_rat(display_long)|uniprotkb:MAPK/ERK kinase kinase 1(gene name synonym)|uniprotkb:Map3k1(gene name)|psi-mi:Map3k1(display_short)|uniprotkb:Mekk(gene name synonym)|uniprotkb:Mekk1(gene name synonym)	psi-mi:tnip1_human(display_long)|uniprotkb:TNIP1(gene name)|psi-mi:TNIP1(display_short)|uniprotkb:KIAA0113(gene name synonym)|uniprotkb:NAF1(gene name synonym)|uniprotkb:Nef-associated factor 1(gene name synonym)|uniprotkb:HIV-1 Nef-interacting protein(gene name synonym)|uniprotkb:Virion-associated nuclear shuttling protein(gene name synonym)|uniprotkb:Nip40-1(gene name synonym)|uniprotkb:A20-binding inhibitor of NF-kappa-B activation 1(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9971861|imex:IM-22822-88	author-confidence:Z-score = 3.89	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:620966|refseq:NP_446339.1|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR007527(Zinc finger, SWIM-type)|go:"GO:0000165"(MAPK cascade)|interpro:IPR016024(Armadillo-type fold)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0002011"(morphogenesis of an epithelial sheet)|go:"GO:0003382"(epithelial cell morphogenesis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004706"(JUN kinase kinase kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007254"(JNK cascade)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008432"(JUN kinase binding)|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0016020"(membrane)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0031434"(mitogen-activated protein kinase kinase binding)|go:"GO:0031941"(filamentous actin)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0042060"(wound healing)|go:"GO:0043010"(camera-type eye development)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046625"(sphingolipid binding)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050434"(positive regulation of viral transcription)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0061029"(eyelid development in camera-type eye)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|reactome:R-RNO-166058|reactome:R-RNO-2871796|reactome:R-RNO-975138|reactome:R-RNO-975871|interpro:IPR011989(Armadillo-like helical)|mint:Q62925	refseq:NP_006049.3|refseq:NP_001239319.1|refseq:NP_001239320.1|refseq:NP_001239321.1|refseq:NP_001239322.1|refseq:NP_001245383.1|dip:DIP-27577N|refseq:NP_001239315.1|ensembl:ENSG00000145901(gene)|ensembl:ENST00000315050(transcript)|ensembl:ENST00000521591(transcript)|ensembl:ENST00000522226(transcript)|go:"GO:0002755"(MyD88-dependent toll-like receptor signaling pathway)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006412"(translation)|go:"GO:0006952"(defense response)|go:"GO:0006954"(inflammatory response)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0009101"(glycoprotein biosynthetic process)|go:"GO:0031593"(polyubiquitin modification-dependent protein binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0085032"(modulation by symbiont of host I-kappaB kinase/NF-kappaB cascade)|go:"GO:1903003"(positive regulation of protein deubiquitination)|interpro:IPR033372|mint:Q15025|reactome:R-HSA-5689896|go:"GO:0051019"(mitogen-activated protein kinase binding)|refseq:NP_001239314.1|refseq:NP_001245384.1|refseq:NP_001245385.1|refseq:XP_006714814.1|refseq:XP_006714815.1	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S3|resulting-ptm:Q15025 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:EwhjYjowkZIAt4UyPcZBUtf9uak10116	rogid:16Vjb5CuGTAbW2M22qbCxgXtV1o9606	intact-crc:49D0D1B7D57ABE14|rigid:1L1D7MkdtNHDAglH241uk7uiP48	false	sufficient binding region:433-481(IPR013083)	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q62925	uniprotkb:Q13404	intact:EBI-636664	intact:EBI-1050671|uniprotkb:Q13403|uniprotkb:Q13532|uniprotkb:Q96H34|uniprotkb:Q9GZT0|uniprotkb:Q9GZW1|uniprotkb:Q9H4J3|uniprotkb:Q9H4J4|uniprotkb:Q9UKL1|uniprotkb:Q9UM48|uniprotkb:Q9UM49|uniprotkb:Q9UM50|uniprotkb:Q5TGE3|uniprotkb:E1P629|uniprotkb:Q5TGE0|ensembl:ENSP00000360739	psi-mi:m3k1_rat(display_long)|uniprotkb:MAPK/ERK kinase kinase 1(gene name synonym)|uniprotkb:Map3k1(gene name)|psi-mi:Map3k1(display_short)|uniprotkb:Mekk(gene name synonym)|uniprotkb:Mekk1(gene name synonym)	psi-mi:ub2v1_human(display_long)|uniprotkb:CROC-1(gene name synonym)|uniprotkb:TRAF6-regulated IKK activator 1 beta Uev1A(gene name synonym)|uniprotkb:P/OKcl.19(orf name)|uniprotkb:UBE2V1(gene name)|psi-mi:UBE2V1(display_short)|uniprotkb:CROC1(gene name synonym)|uniprotkb:UBE2V(gene name synonym)|uniprotkb:UEV1(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9971861|imex:IM-22822-88	author-confidence:Z-score = 3.89	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:620966|refseq:NP_446339.1|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR007527(Zinc finger, SWIM-type)|go:"GO:0000165"(MAPK cascade)|interpro:IPR016024(Armadillo-type fold)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0002011"(morphogenesis of an epithelial sheet)|go:"GO:0003382"(epithelial cell morphogenesis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004706"(JUN kinase kinase kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007254"(JNK cascade)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008432"(JUN kinase binding)|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0016020"(membrane)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0031434"(mitogen-activated protein kinase kinase binding)|go:"GO:0031941"(filamentous actin)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0042060"(wound healing)|go:"GO:0043010"(camera-type eye development)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046625"(sphingolipid binding)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050434"(positive regulation of viral transcription)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0061029"(eyelid development in camera-type eye)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|reactome:R-RNO-166058|reactome:R-RNO-2871796|reactome:R-RNO-975138|reactome:R-RNO-975871|interpro:IPR011989(Armadillo-like helical)|mint:Q62925	refseq:NP_001027459.1|refseq:NP_068823.2|refseq:NP_071887.1|refseq:NP_954595.1|refseq:NP_954673.1|refseq:NP_001244322.1|refseq:NP_001244323.1|refseq:NP_001244325.1|ensembl:ENSG00000244687(gene)|ensembl:ENST00000371674(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006282"(regulation of DNA repair)|go:"GO:0006301"(postreplication repair)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0030154"(cell differentiation)|go:"GO:0031371"(ubiquitin conjugating enzyme complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035370"(UBC13-UEV1A complex)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070534"(protein K63-linked ubiquitination)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|rcsb pdb:2A4D|rcsb pdb:2C2V|rcsb pdb:2HLW|rcsb pdb:6D6I|reactome:R-HSA-168638|reactome:R-HSA-168927|reactome:R-HSA-202424|reactome:R-HSA-2871837|reactome:R-HSA-445989|reactome:R-HSA-450302|reactome:R-HSA-450321|reactome:R-HSA-5607764|reactome:R-HSA-9020702|reactome:R-HSA-937039|reactome:R-HSA-937041|reactome:R-HSA-9646399|reactome:R-HSA-975110|reactome:R-HSA-975144|reactome:R-HSA-983168|dip:DIP-41911N	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S3|resulting-ptm:Q15025 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:EwhjYjowkZIAt4UyPcZBUtf9uak10116	rogid:x95N7Dj2KIqu5gySX59xLmfthUg9606	intact-crc:49D0D1B7D57ABE14|rigid:1L1D7MkdtNHDAglH241uk7uiP48	false	sufficient binding region:433-481(IPR013083)	his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q62925	uniprotkb:P22314	intact:EBI-636664	intact:EBI-709688|uniprotkb:Q96E13|uniprotkb:Q5JRR8|ensembl:ENSP00000338413|ensembl:ENSP00000366568	psi-mi:m3k1_rat(display_long)|uniprotkb:MAPK/ERK kinase kinase 1(gene name synonym)|uniprotkb:Map3k1(gene name)|psi-mi:Map3k1(display_short)|uniprotkb:Mekk(gene name synonym)|uniprotkb:Mekk1(gene name synonym)	psi-mi:uba1_human(display_long)|uniprotkb:Ubiquitin-activating enzyme E1(gene name synonym)|uniprotkb:Protein A1S9(gene name synonym)|uniprotkb:UBA1(gene name)|psi-mi:UBA1(display_short)|uniprotkb:A1S9T(gene name synonym)|uniprotkb:UBE1(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9971861|imex:IM-22822-88	author-confidence:Z-score = 3.89	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:620966|refseq:NP_446339.1|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR007527(Zinc finger, SWIM-type)|go:"GO:0000165"(MAPK cascade)|interpro:IPR016024(Armadillo-type fold)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0002011"(morphogenesis of an epithelial sheet)|go:"GO:0003382"(epithelial cell morphogenesis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004706"(JUN kinase kinase kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007254"(JNK cascade)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008432"(JUN kinase binding)|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0016020"(membrane)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0031434"(mitogen-activated protein kinase kinase binding)|go:"GO:0031941"(filamentous actin)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0042060"(wound healing)|go:"GO:0043010"(camera-type eye development)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046625"(sphingolipid binding)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050434"(positive regulation of viral transcription)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0061029"(eyelid development in camera-type eye)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|reactome:R-RNO-166058|reactome:R-RNO-2871796|reactome:R-RNO-975138|reactome:R-RNO-975871|interpro:IPR011989(Armadillo-like helical)|mint:Q62925	refseq:NP_003325.2|refseq:NP_695012.1|refseq:XP_016885269.1|refseq:XP_016885270.1|dip:DIP-33686N|ensembl:ENSG00000130985(gene)|ensembl:ENST00000335972(transcript)|ensembl:ENST00000377351(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0004839"(ubiquitin activating enzyme activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0032446"(protein modification by small protein conjugation)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000011(Ubiquitin-activating enzyme, E1)|interpro:IPR000594(UBA/THIF-type NAD/FAD binding fold)|interpro:IPR018074|interpro:IPR018075|interpro:IPR018965|interpro:IPR019572|interpro:IPR032418|interpro:IPR032420|interpro:IPR033127|interpro:IPR035985|interpro:IPR038252|interpro:IPR042063|interpro:IPR042302|interpro:IPR042449|mint:P22314|rcsb pdb:4P22|rcsb pdb:6DC6|reactome:R-HSA-8866652|reactome:R-HSA-983168	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S3|resulting-ptm:Q15025 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:EwhjYjowkZIAt4UyPcZBUtf9uak10116	rogid:q+vEeA0XLST0Zz173bmEt0dNbDE9606	intact-crc:49D0D1B7D57ABE14|rigid:1L1D7MkdtNHDAglH241uk7uiP48	false	sufficient binding region:433-481(IPR013083)	his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q62925	uniprotkb:P61088	intact:EBI-636664	intact:EBI-1052908|uniprotkb:Q16781|uniprotkb:Q53Y81|ensembl:ENSP00000316176	psi-mi:m3k1_rat(display_long)|uniprotkb:MAPK/ERK kinase kinase 1(gene name synonym)|uniprotkb:Map3k1(gene name)|psi-mi:Map3k1(display_short)|uniprotkb:Mekk(gene name synonym)|uniprotkb:Mekk1(gene name synonym)	psi-mi:ube2n_human(display_long)|uniprotkb:Ubiquitin-protein ligase N(gene name synonym)|uniprotkb:Ubiquitin carrier protein N(gene name synonym)|uniprotkb:Ubc13(gene name synonym)|uniprotkb:Bendless-like ubiquitin-conjugating enzyme(gene name synonym)|uniprotkb:UBE2N(gene name)|psi-mi:UBE2N(display_short)|uniprotkb:BLU(gene name synonym)|uniprotkb:UbcH13(gene name synonym)|uniprotkb:E2 ubiquitin-conjugating enzyme N(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9971861|imex:IM-22822-88	author-confidence:Z-score = 3.89	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:620966|refseq:NP_446339.1|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR007527(Zinc finger, SWIM-type)|go:"GO:0000165"(MAPK cascade)|interpro:IPR016024(Armadillo-type fold)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0002011"(morphogenesis of an epithelial sheet)|go:"GO:0003382"(epithelial cell morphogenesis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004706"(JUN kinase kinase kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007254"(JNK cascade)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008432"(JUN kinase binding)|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0016020"(membrane)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0031434"(mitogen-activated protein kinase kinase binding)|go:"GO:0031941"(filamentous actin)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0042060"(wound healing)|go:"GO:0043010"(camera-type eye development)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046625"(sphingolipid binding)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050434"(positive regulation of viral transcription)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0061029"(eyelid development in camera-type eye)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|reactome:R-RNO-166058|reactome:R-RNO-2871796|reactome:R-RNO-975138|reactome:R-RNO-975871|interpro:IPR011989(Armadillo-like helical)|mint:Q62925	refseq:NP_003339.1|dip:DIP-29829N|ensembl:ENSG00000177889(gene)|ensembl:ENST00000318066(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000729"(DNA double-strand break processing)|go:"GO:0001650"(fibrillar center)|go:"GO:0003723"(RNA binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006282"(regulation of DNA repair)|go:"GO:0006301"(postreplication repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016574"(histone ubiquitination)|go:"GO:0031058"(positive regulation of histone modification)|go:"GO:0031372"(UBC13-MMS2 complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033182"(regulation of histone ubiquitination)|go:"GO:0035370"(UBC13-UEV1A complex)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0061631"(ubiquitin conjugating enzyme activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070534"(protein K63-linked ubiquitination)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|interpro:IPR023313|rcsb pdb:1J7D|rcsb pdb:2C2V|rcsb pdb:3HCT|rcsb pdb:3HCU|rcsb pdb:3VON|rcsb pdb:3W31|rcsb pdb:4DHI|rcsb pdb:4DHJ|rcsb pdb:4DHZ|rcsb pdb:4IP3|rcsb pdb:4NR3|rcsb pdb:4NRG|rcsb pdb:4NRI|rcsb pdb:4ONL|rcsb pdb:4ONM|rcsb pdb:4ONN|rcsb pdb:4ORH|rcsb pdb:4TKP|rcsb pdb:4WHV|rcsb pdb:5AIT|rcsb pdb:5AIU|rcsb pdb:5EYA|rcsb pdb:5H7S|rcsb pdb:5VNZ|rcsb pdb:5VO0|rcsb pdb:5YWR|rcsb pdb:6D6I|rcsb pdb:6JKY|rcsb pdb:6KFP|rcsb pdb:6KG6|rcsb pdb:6KL4|rcsb pdb:6LP2|rcsb pdb:6P5B|rcsb pdb:6S53|reactome:R-HSA-168927|reactome:R-HSA-202424|reactome:R-HSA-2871837|reactome:R-HSA-445989|reactome:R-HSA-450302|reactome:R-HSA-450321|reactome:R-HSA-5607764|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-5696395|reactome:R-HSA-69473|reactome:R-HSA-8866654|reactome:R-HSA-9020702|reactome:R-HSA-937039|reactome:R-HSA-937041|reactome:R-HSA-9646399|reactome:R-HSA-975110|reactome:R-HSA-975144|reactome:R-HSA-983168|rcsb pdb:6ULH|rcsb pdb:6UMP|rcsb pdb:6UMS|rcsb pdb:7BBD|rcsb pdb:7BBF|rcsb pdb:7BXG|reactome:R-HSA-1169408|reactome:R-HSA-168638	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S3|resulting-ptm:Q15025 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:EwhjYjowkZIAt4UyPcZBUtf9uak10116	rogid:dqdszHlq5FLPHC6UWX6uvkC6Yz89606	intact-crc:49D0D1B7D57ABE14|rigid:1L1D7MkdtNHDAglH241uk7uiP48	false	sufficient binding region:433-481(IPR013083)	his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q4V328	uniprotkb:Q62925	intact:EBI-717919|uniprotkb:A6NL78|uniprotkb:Q3MJ75|uniprotkb:Q4V327|uniprotkb:Q4V330|uniprotkb:Q5HYG1|uniprotkb:Q6N046|uniprotkb:Q96DH8|uniprotkb:Q9NQ43|uniprotkb:Q9ULQ3|ensembl:ENSP00000365606	intact:EBI-636664	psi-mi:grap1_human(display_long)|uniprotkb:GRIPAP1(gene name)|psi-mi:GRIPAP1(display_short)|uniprotkb:KIAA1167(gene name synonym)	psi-mi:m3k1_rat(display_long)|uniprotkb:MAPK/ERK kinase kinase 1(gene name synonym)|uniprotkb:Map3k1(gene name)|psi-mi:Map3k1(display_short)|uniprotkb:Mekk(gene name synonym)|uniprotkb:Mekk1(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9971911|imex:IM-22822-90	author-confidence:Z-score = 8.68	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_064522.3|ensembl:ENSG00000068400(gene)|ensembl:ENST00000376423(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0072562"(blood microparticle)|go:"GO:0098837"(postsynaptic recycling endosome)|go:"GO:0098887"(neurotransmitter receptor transport, endosome to postsynaptic membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098998"(extrinsic component of postsynaptic early endosome membrane)|go:"GO:0099152"(regulation of neurotransmitter receptor transport, endosome to postsynaptic membrane)|go:"GO:0099158"(regulation of recycling endosome localization within postsynapse)|go:"GO:1905244"(regulation of modification of synaptic structure)|interpro:IPR026204|mint:Q4V328|dip:DIP-47299N	rgd:620966|refseq:NP_446339.1|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR007527(Zinc finger, SWIM-type)|go:"GO:0000165"(MAPK cascade)|interpro:IPR016024(Armadillo-type fold)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0002011"(morphogenesis of an epithelial sheet)|go:"GO:0003382"(epithelial cell morphogenesis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004706"(JUN kinase kinase kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007254"(JNK cascade)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008432"(JUN kinase binding)|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0016020"(membrane)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0031434"(mitogen-activated protein kinase kinase binding)|go:"GO:0031941"(filamentous actin)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0042060"(wound healing)|go:"GO:0043010"(camera-type eye development)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046625"(sphingolipid binding)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050434"(positive regulation of viral transcription)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0061029"(eyelid development in camera-type eye)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|reactome:R-RNO-166058|reactome:R-RNO-2871796|reactome:R-RNO-975138|reactome:R-RNO-975871|interpro:IPR011989(Armadillo-like helical)|mint:Q62925	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S3|resulting-ptm:Q4V328 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2018/09/18	rogid:iIGfz5XvbexX4taRlMqWYsfAVBo9606	rogid:EwhjYjowkZIAt4UyPcZBUtf9uak10116	intact-crc:6605E099E021CF25|rigid:QPARNAZRpWWa0OL7u1pDnL3QR0I	false	-	sufficient binding region:433-481(IPR013083)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q4V328	uniprotkb:Q13404	intact:EBI-717919|uniprotkb:A6NL78|uniprotkb:Q3MJ75|uniprotkb:Q4V327|uniprotkb:Q4V330|uniprotkb:Q5HYG1|uniprotkb:Q6N046|uniprotkb:Q96DH8|uniprotkb:Q9NQ43|uniprotkb:Q9ULQ3|ensembl:ENSP00000365606	intact:EBI-1050671|uniprotkb:Q13403|uniprotkb:Q13532|uniprotkb:Q96H34|uniprotkb:Q9GZT0|uniprotkb:Q9GZW1|uniprotkb:Q9H4J3|uniprotkb:Q9H4J4|uniprotkb:Q9UKL1|uniprotkb:Q9UM48|uniprotkb:Q9UM49|uniprotkb:Q9UM50|uniprotkb:Q5TGE3|uniprotkb:E1P629|uniprotkb:Q5TGE0|ensembl:ENSP00000360739	psi-mi:grap1_human(display_long)|uniprotkb:GRIPAP1(gene name)|psi-mi:GRIPAP1(display_short)|uniprotkb:KIAA1167(gene name synonym)	psi-mi:ub2v1_human(display_long)|uniprotkb:CROC-1(gene name synonym)|uniprotkb:TRAF6-regulated IKK activator 1 beta Uev1A(gene name synonym)|uniprotkb:P/OKcl.19(orf name)|uniprotkb:UBE2V1(gene name)|psi-mi:UBE2V1(display_short)|uniprotkb:CROC1(gene name synonym)|uniprotkb:UBE2V(gene name synonym)|uniprotkb:UEV1(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9971911|imex:IM-22822-90	author-confidence:Z-score = 8.68	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_064522.3|ensembl:ENSG00000068400(gene)|ensembl:ENST00000376423(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0072562"(blood microparticle)|go:"GO:0098837"(postsynaptic recycling endosome)|go:"GO:0098887"(neurotransmitter receptor transport, endosome to postsynaptic membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098998"(extrinsic component of postsynaptic early endosome membrane)|go:"GO:0099152"(regulation of neurotransmitter receptor transport, endosome to postsynaptic membrane)|go:"GO:0099158"(regulation of recycling endosome localization within postsynapse)|go:"GO:1905244"(regulation of modification of synaptic structure)|interpro:IPR026204|mint:Q4V328|dip:DIP-47299N	refseq:NP_001027459.1|refseq:NP_068823.2|refseq:NP_071887.1|refseq:NP_954595.1|refseq:NP_954673.1|refseq:NP_001244322.1|refseq:NP_001244323.1|refseq:NP_001244325.1|ensembl:ENSG00000244687(gene)|ensembl:ENST00000371674(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006282"(regulation of DNA repair)|go:"GO:0006301"(postreplication repair)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0030154"(cell differentiation)|go:"GO:0031371"(ubiquitin conjugating enzyme complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035370"(UBC13-UEV1A complex)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070534"(protein K63-linked ubiquitination)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|rcsb pdb:2A4D|rcsb pdb:2C2V|rcsb pdb:2HLW|rcsb pdb:6D6I|reactome:R-HSA-168638|reactome:R-HSA-168927|reactome:R-HSA-202424|reactome:R-HSA-2871837|reactome:R-HSA-445989|reactome:R-HSA-450302|reactome:R-HSA-450321|reactome:R-HSA-5607764|reactome:R-HSA-9020702|reactome:R-HSA-937039|reactome:R-HSA-937041|reactome:R-HSA-9646399|reactome:R-HSA-975110|reactome:R-HSA-975144|reactome:R-HSA-983168|dip:DIP-41911N	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S3|resulting-ptm:Q4V328 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2018/09/18	rogid:iIGfz5XvbexX4taRlMqWYsfAVBo9606	rogid:x95N7Dj2KIqu5gySX59xLmfthUg9606	intact-crc:6605E099E021CF25|rigid:QPARNAZRpWWa0OL7u1pDnL3QR0I	false	-	his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q4V328	uniprotkb:P22314	intact:EBI-717919|uniprotkb:A6NL78|uniprotkb:Q3MJ75|uniprotkb:Q4V327|uniprotkb:Q4V330|uniprotkb:Q5HYG1|uniprotkb:Q6N046|uniprotkb:Q96DH8|uniprotkb:Q9NQ43|uniprotkb:Q9ULQ3|ensembl:ENSP00000365606	intact:EBI-709688|uniprotkb:Q96E13|uniprotkb:Q5JRR8|ensembl:ENSP00000338413|ensembl:ENSP00000366568	psi-mi:grap1_human(display_long)|uniprotkb:GRIPAP1(gene name)|psi-mi:GRIPAP1(display_short)|uniprotkb:KIAA1167(gene name synonym)	psi-mi:uba1_human(display_long)|uniprotkb:Ubiquitin-activating enzyme E1(gene name synonym)|uniprotkb:Protein A1S9(gene name synonym)|uniprotkb:UBA1(gene name)|psi-mi:UBA1(display_short)|uniprotkb:A1S9T(gene name synonym)|uniprotkb:UBE1(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9971911|imex:IM-22822-90	author-confidence:Z-score = 8.68	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_064522.3|ensembl:ENSG00000068400(gene)|ensembl:ENST00000376423(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0072562"(blood microparticle)|go:"GO:0098837"(postsynaptic recycling endosome)|go:"GO:0098887"(neurotransmitter receptor transport, endosome to postsynaptic membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098998"(extrinsic component of postsynaptic early endosome membrane)|go:"GO:0099152"(regulation of neurotransmitter receptor transport, endosome to postsynaptic membrane)|go:"GO:0099158"(regulation of recycling endosome localization within postsynapse)|go:"GO:1905244"(regulation of modification of synaptic structure)|interpro:IPR026204|mint:Q4V328|dip:DIP-47299N	refseq:NP_003325.2|refseq:NP_695012.1|refseq:XP_016885269.1|refseq:XP_016885270.1|dip:DIP-33686N|ensembl:ENSG00000130985(gene)|ensembl:ENST00000335972(transcript)|ensembl:ENST00000377351(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0004839"(ubiquitin activating enzyme activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0032446"(protein modification by small protein conjugation)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000011(Ubiquitin-activating enzyme, E1)|interpro:IPR000594(UBA/THIF-type NAD/FAD binding fold)|interpro:IPR018074|interpro:IPR018075|interpro:IPR018965|interpro:IPR019572|interpro:IPR032418|interpro:IPR032420|interpro:IPR033127|interpro:IPR035985|interpro:IPR038252|interpro:IPR042063|interpro:IPR042302|interpro:IPR042449|mint:P22314|rcsb pdb:4P22|rcsb pdb:6DC6|reactome:R-HSA-8866652|reactome:R-HSA-983168	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S3|resulting-ptm:Q4V328 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2018/09/18	rogid:iIGfz5XvbexX4taRlMqWYsfAVBo9606	rogid:q+vEeA0XLST0Zz173bmEt0dNbDE9606	intact-crc:6605E099E021CF25|rigid:QPARNAZRpWWa0OL7u1pDnL3QR0I	false	-	his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q4V328	uniprotkb:P61088	intact:EBI-717919|uniprotkb:A6NL78|uniprotkb:Q3MJ75|uniprotkb:Q4V327|uniprotkb:Q4V330|uniprotkb:Q5HYG1|uniprotkb:Q6N046|uniprotkb:Q96DH8|uniprotkb:Q9NQ43|uniprotkb:Q9ULQ3|ensembl:ENSP00000365606	intact:EBI-1052908|uniprotkb:Q16781|uniprotkb:Q53Y81|ensembl:ENSP00000316176	psi-mi:grap1_human(display_long)|uniprotkb:GRIPAP1(gene name)|psi-mi:GRIPAP1(display_short)|uniprotkb:KIAA1167(gene name synonym)	psi-mi:ube2n_human(display_long)|uniprotkb:Ubiquitin-protein ligase N(gene name synonym)|uniprotkb:Ubiquitin carrier protein N(gene name synonym)|uniprotkb:Ubc13(gene name synonym)|uniprotkb:Bendless-like ubiquitin-conjugating enzyme(gene name synonym)|uniprotkb:UBE2N(gene name)|psi-mi:UBE2N(display_short)|uniprotkb:BLU(gene name synonym)|uniprotkb:UbcH13(gene name synonym)|uniprotkb:E2 ubiquitin-conjugating enzyme N(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9971911|imex:IM-22822-90	author-confidence:Z-score = 8.68	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_064522.3|ensembl:ENSG00000068400(gene)|ensembl:ENST00000376423(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0072562"(blood microparticle)|go:"GO:0098837"(postsynaptic recycling endosome)|go:"GO:0098887"(neurotransmitter receptor transport, endosome to postsynaptic membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098998"(extrinsic component of postsynaptic early endosome membrane)|go:"GO:0099152"(regulation of neurotransmitter receptor transport, endosome to postsynaptic membrane)|go:"GO:0099158"(regulation of recycling endosome localization within postsynapse)|go:"GO:1905244"(regulation of modification of synaptic structure)|interpro:IPR026204|mint:Q4V328|dip:DIP-47299N	refseq:NP_003339.1|dip:DIP-29829N|ensembl:ENSG00000177889(gene)|ensembl:ENST00000318066(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000729"(DNA double-strand break processing)|go:"GO:0001650"(fibrillar center)|go:"GO:0003723"(RNA binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006282"(regulation of DNA repair)|go:"GO:0006301"(postreplication repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016574"(histone ubiquitination)|go:"GO:0031058"(positive regulation of histone modification)|go:"GO:0031372"(UBC13-MMS2 complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033182"(regulation of histone ubiquitination)|go:"GO:0035370"(UBC13-UEV1A complex)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0061631"(ubiquitin conjugating enzyme activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070534"(protein K63-linked ubiquitination)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|interpro:IPR023313|rcsb pdb:1J7D|rcsb pdb:2C2V|rcsb pdb:3HCT|rcsb pdb:3HCU|rcsb pdb:3VON|rcsb pdb:3W31|rcsb pdb:4DHI|rcsb pdb:4DHJ|rcsb pdb:4DHZ|rcsb pdb:4IP3|rcsb pdb:4NR3|rcsb pdb:4NRG|rcsb pdb:4NRI|rcsb pdb:4ONL|rcsb pdb:4ONM|rcsb pdb:4ONN|rcsb pdb:4ORH|rcsb pdb:4TKP|rcsb pdb:4WHV|rcsb pdb:5AIT|rcsb pdb:5AIU|rcsb pdb:5EYA|rcsb pdb:5H7S|rcsb pdb:5VNZ|rcsb pdb:5VO0|rcsb pdb:5YWR|rcsb pdb:6D6I|rcsb pdb:6JKY|rcsb pdb:6KFP|rcsb pdb:6KG6|rcsb pdb:6KL4|rcsb pdb:6LP2|rcsb pdb:6P5B|rcsb pdb:6S53|reactome:R-HSA-168927|reactome:R-HSA-202424|reactome:R-HSA-2871837|reactome:R-HSA-445989|reactome:R-HSA-450302|reactome:R-HSA-450321|reactome:R-HSA-5607764|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-5696395|reactome:R-HSA-69473|reactome:R-HSA-8866654|reactome:R-HSA-9020702|reactome:R-HSA-937039|reactome:R-HSA-937041|reactome:R-HSA-9646399|reactome:R-HSA-975110|reactome:R-HSA-975144|reactome:R-HSA-983168|rcsb pdb:6ULH|rcsb pdb:6UMP|rcsb pdb:6UMS|rcsb pdb:7BBD|rcsb pdb:7BBF|rcsb pdb:7BXG|reactome:R-HSA-1169408|reactome:R-HSA-168638	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S3|resulting-ptm:Q4V328 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2018/09/18	rogid:iIGfz5XvbexX4taRlMqWYsfAVBo9606	rogid:dqdszHlq5FLPHC6UWX6uvkC6Yz89606	intact-crc:6605E099E021CF25|rigid:QPARNAZRpWWa0OL7u1pDnL3QR0I	false	-	his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q62925	uniprotkb:Q15750	intact:EBI-636664	intact:EBI-358643|uniprotkb:Q2PP09|intact:EBI-3959873|uniprotkb:Q8IZW2|ensembl:ENSP00000216160	psi-mi:m3k1_rat(display_long)|uniprotkb:MAPK/ERK kinase kinase 1(gene name synonym)|uniprotkb:Map3k1(gene name)|psi-mi:Map3k1(display_short)|uniprotkb:Mekk(gene name synonym)|uniprotkb:Mekk1(gene name synonym)	psi-mi:tab1_human(display_long)|uniprotkb:TAB1(gene name)|psi-mi:TAB1(display_short)|uniprotkb:MAP3K7IP1(gene name synonym)|uniprotkb:TGF-beta-activated kinase 1-binding protein 1(gene name synonym)|uniprotkb:Mitogen-activated protein kinase kinase kinase 7-interacting protein 1(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9971886|imex:IM-22822-89	author-confidence:Z-score = 10.24	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:620966|refseq:NP_446339.1|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR007527(Zinc finger, SWIM-type)|go:"GO:0000165"(MAPK cascade)|interpro:IPR016024(Armadillo-type fold)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0002011"(morphogenesis of an epithelial sheet)|go:"GO:0003382"(epithelial cell morphogenesis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004706"(JUN kinase kinase kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007254"(JNK cascade)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008432"(JUN kinase binding)|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0016020"(membrane)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0031434"(mitogen-activated protein kinase kinase binding)|go:"GO:0031941"(filamentous actin)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0042060"(wound healing)|go:"GO:0043010"(camera-type eye development)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046625"(sphingolipid binding)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050434"(positive regulation of viral transcription)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0061029"(eyelid development in camera-type eye)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|reactome:R-RNO-166058|reactome:R-RNO-2871796|reactome:R-RNO-975138|reactome:R-RNO-975871|interpro:IPR011989(Armadillo-like helical)|mint:Q62925	refseq:NP_006107.1|refseq:NP_705717.1|ensembl:ENSP00000216160|ensembl:ENST00000331454|ensembl:ENSP00000333049|go:"GO:0003279"(cardiac septum development)|rcsb pdb:7NTI|go:"GO:0003007"(heart morphogenesis)|ensembl:ENSG00000100324(gene)|ensembl:ENST00000216160(transcript)|go:"GO:0000185"(obsolete activation of MAPKKK activity)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0008047"(enzyme activator activity)|go:"GO:0010008"(endosome membrane)|go:"GO:0016607"(nuclear speck)|go:"GO:0016791"(phosphatase activity)|go:"GO:0019209"(kinase activator activity)|go:"GO:0030324"(lung development)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035904"(aorta development)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0048273"(mitogen-activated protein kinase p38 binding)|go:"GO:0060976"(coronary vasculature development)|interpro:IPR001932(Protein phosphatase 2C-related)|interpro:IPR015655(Protein phosphatase 2C)|interpro:IPR036457|mint:Q15750|rcsb pdb:2J4O|rcsb pdb:2POM|rcsb pdb:2POP|rcsb pdb:2YDS|rcsb pdb:2YIY|rcsb pdb:4AY5|rcsb pdb:4AY6|rcsb pdb:4GS6|rcsb pdb:4KA3|rcsb pdb:4L3P|rcsb pdb:4L52|rcsb pdb:4L53|rcsb pdb:4O91|rcsb pdb:5DIY|rcsb pdb:5E7R|rcsb pdb:5GJD|rcsb pdb:5GJF|rcsb pdb:5GJG|rcsb pdb:5J7S|rcsb pdb:5J8I|rcsb pdb:5J9L|rcsb pdb:5JGA|rcsb pdb:5JGB|rcsb pdb:5JGD|rcsb pdb:5JH6|rcsb pdb:5JK3|rcsb pdb:5NZZ|rcsb pdb:5O90|rcsb pdb:5V5N|rcsb pdb:5VVU|rcsb pdb:7NTH|reactome:R-HSA-168638|reactome:R-HSA-2871837|reactome:R-HSA-445989|reactome:R-HSA-450302|reactome:R-HSA-450321|reactome:R-HSA-5357956|reactome:R-HSA-5607764|reactome:R-HSA-5689880|reactome:R-HSA-9014325|reactome:R-HSA-9020702|reactome:R-HSA-937042|reactome:R-HSA-937072|reactome:R-HSA-9645460|reactome:R-HSA-975163|dip:DIP-27524N	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S3|resulting-ptm:Q15750 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:EwhjYjowkZIAt4UyPcZBUtf9uak10116	rogid:28+bzs6bpXJTun4XukxC/7oAYSs9606	intact-crc:5CC6A3DF5966BFBF|rigid:FhGUf1R51RDJrQ0DSQjYaNcxjQ0	false	sufficient binding region:433-481(IPR013083)	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q62925	uniprotkb:Q13404	intact:EBI-636664	intact:EBI-1050671|uniprotkb:Q13403|uniprotkb:Q13532|uniprotkb:Q96H34|uniprotkb:Q9GZT0|uniprotkb:Q9GZW1|uniprotkb:Q9H4J3|uniprotkb:Q9H4J4|uniprotkb:Q9UKL1|uniprotkb:Q9UM48|uniprotkb:Q9UM49|uniprotkb:Q9UM50|uniprotkb:Q5TGE3|uniprotkb:E1P629|uniprotkb:Q5TGE0|ensembl:ENSP00000360739	psi-mi:m3k1_rat(display_long)|uniprotkb:MAPK/ERK kinase kinase 1(gene name synonym)|uniprotkb:Map3k1(gene name)|psi-mi:Map3k1(display_short)|uniprotkb:Mekk(gene name synonym)|uniprotkb:Mekk1(gene name synonym)	psi-mi:ub2v1_human(display_long)|uniprotkb:CROC-1(gene name synonym)|uniprotkb:TRAF6-regulated IKK activator 1 beta Uev1A(gene name synonym)|uniprotkb:P/OKcl.19(orf name)|uniprotkb:UBE2V1(gene name)|psi-mi:UBE2V1(display_short)|uniprotkb:CROC1(gene name synonym)|uniprotkb:UBE2V(gene name synonym)|uniprotkb:UEV1(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9971886|imex:IM-22822-89	author-confidence:Z-score = 10.24	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:620966|refseq:NP_446339.1|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR007527(Zinc finger, SWIM-type)|go:"GO:0000165"(MAPK cascade)|interpro:IPR016024(Armadillo-type fold)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0002011"(morphogenesis of an epithelial sheet)|go:"GO:0003382"(epithelial cell morphogenesis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004706"(JUN kinase kinase kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007254"(JNK cascade)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008432"(JUN kinase binding)|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0016020"(membrane)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0031434"(mitogen-activated protein kinase kinase binding)|go:"GO:0031941"(filamentous actin)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0042060"(wound healing)|go:"GO:0043010"(camera-type eye development)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046625"(sphingolipid binding)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050434"(positive regulation of viral transcription)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0061029"(eyelid development in camera-type eye)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|reactome:R-RNO-166058|reactome:R-RNO-2871796|reactome:R-RNO-975138|reactome:R-RNO-975871|interpro:IPR011989(Armadillo-like helical)|mint:Q62925	refseq:NP_001027459.1|refseq:NP_068823.2|refseq:NP_071887.1|refseq:NP_954595.1|refseq:NP_954673.1|refseq:NP_001244322.1|refseq:NP_001244323.1|refseq:NP_001244325.1|ensembl:ENSG00000244687(gene)|ensembl:ENST00000371674(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006282"(regulation of DNA repair)|go:"GO:0006301"(postreplication repair)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0030154"(cell differentiation)|go:"GO:0031371"(ubiquitin conjugating enzyme complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035370"(UBC13-UEV1A complex)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070534"(protein K63-linked ubiquitination)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|rcsb pdb:2A4D|rcsb pdb:2C2V|rcsb pdb:2HLW|rcsb pdb:6D6I|reactome:R-HSA-168638|reactome:R-HSA-168927|reactome:R-HSA-202424|reactome:R-HSA-2871837|reactome:R-HSA-445989|reactome:R-HSA-450302|reactome:R-HSA-450321|reactome:R-HSA-5607764|reactome:R-HSA-9020702|reactome:R-HSA-937039|reactome:R-HSA-937041|reactome:R-HSA-9646399|reactome:R-HSA-975110|reactome:R-HSA-975144|reactome:R-HSA-983168|dip:DIP-41911N	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S3|resulting-ptm:Q15750 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:EwhjYjowkZIAt4UyPcZBUtf9uak10116	rogid:x95N7Dj2KIqu5gySX59xLmfthUg9606	intact-crc:5CC6A3DF5966BFBF|rigid:FhGUf1R51RDJrQ0DSQjYaNcxjQ0	false	sufficient binding region:433-481(IPR013083)	his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q62925	uniprotkb:P22314	intact:EBI-636664	intact:EBI-709688|uniprotkb:Q96E13|uniprotkb:Q5JRR8|ensembl:ENSP00000338413|ensembl:ENSP00000366568	psi-mi:m3k1_rat(display_long)|uniprotkb:MAPK/ERK kinase kinase 1(gene name synonym)|uniprotkb:Map3k1(gene name)|psi-mi:Map3k1(display_short)|uniprotkb:Mekk(gene name synonym)|uniprotkb:Mekk1(gene name synonym)	psi-mi:uba1_human(display_long)|uniprotkb:Ubiquitin-activating enzyme E1(gene name synonym)|uniprotkb:Protein A1S9(gene name synonym)|uniprotkb:UBA1(gene name)|psi-mi:UBA1(display_short)|uniprotkb:A1S9T(gene name synonym)|uniprotkb:UBE1(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9971886|imex:IM-22822-89	author-confidence:Z-score = 10.24	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:620966|refseq:NP_446339.1|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR007527(Zinc finger, SWIM-type)|go:"GO:0000165"(MAPK cascade)|interpro:IPR016024(Armadillo-type fold)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0002011"(morphogenesis of an epithelial sheet)|go:"GO:0003382"(epithelial cell morphogenesis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004706"(JUN kinase kinase kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007254"(JNK cascade)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008432"(JUN kinase binding)|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0016020"(membrane)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0031434"(mitogen-activated protein kinase kinase binding)|go:"GO:0031941"(filamentous actin)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0042060"(wound healing)|go:"GO:0043010"(camera-type eye development)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046625"(sphingolipid binding)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050434"(positive regulation of viral transcription)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0061029"(eyelid development in camera-type eye)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|reactome:R-RNO-166058|reactome:R-RNO-2871796|reactome:R-RNO-975138|reactome:R-RNO-975871|interpro:IPR011989(Armadillo-like helical)|mint:Q62925	refseq:NP_003325.2|refseq:NP_695012.1|refseq:XP_016885269.1|refseq:XP_016885270.1|dip:DIP-33686N|ensembl:ENSG00000130985(gene)|ensembl:ENST00000335972(transcript)|ensembl:ENST00000377351(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0004839"(ubiquitin activating enzyme activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0032446"(protein modification by small protein conjugation)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000011(Ubiquitin-activating enzyme, E1)|interpro:IPR000594(UBA/THIF-type NAD/FAD binding fold)|interpro:IPR018074|interpro:IPR018075|interpro:IPR018965|interpro:IPR019572|interpro:IPR032418|interpro:IPR032420|interpro:IPR033127|interpro:IPR035985|interpro:IPR038252|interpro:IPR042063|interpro:IPR042302|interpro:IPR042449|mint:P22314|rcsb pdb:4P22|rcsb pdb:6DC6|reactome:R-HSA-8866652|reactome:R-HSA-983168	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S3|resulting-ptm:Q15750 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:EwhjYjowkZIAt4UyPcZBUtf9uak10116	rogid:q+vEeA0XLST0Zz173bmEt0dNbDE9606	intact-crc:5CC6A3DF5966BFBF|rigid:FhGUf1R51RDJrQ0DSQjYaNcxjQ0	false	sufficient binding region:433-481(IPR013083)	his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q62925	uniprotkb:P61088	intact:EBI-636664	intact:EBI-1052908|uniprotkb:Q16781|uniprotkb:Q53Y81|ensembl:ENSP00000316176	psi-mi:m3k1_rat(display_long)|uniprotkb:MAPK/ERK kinase kinase 1(gene name synonym)|uniprotkb:Map3k1(gene name)|psi-mi:Map3k1(display_short)|uniprotkb:Mekk(gene name synonym)|uniprotkb:Mekk1(gene name synonym)	psi-mi:ube2n_human(display_long)|uniprotkb:Ubiquitin-protein ligase N(gene name synonym)|uniprotkb:Ubiquitin carrier protein N(gene name synonym)|uniprotkb:Ubc13(gene name synonym)|uniprotkb:Bendless-like ubiquitin-conjugating enzyme(gene name synonym)|uniprotkb:UBE2N(gene name)|psi-mi:UBE2N(display_short)|uniprotkb:BLU(gene name synonym)|uniprotkb:UbcH13(gene name synonym)|uniprotkb:E2 ubiquitin-conjugating enzyme N(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9971886|imex:IM-22822-89	author-confidence:Z-score = 10.24	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:620966|refseq:NP_446339.1|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR007527(Zinc finger, SWIM-type)|go:"GO:0000165"(MAPK cascade)|interpro:IPR016024(Armadillo-type fold)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0002011"(morphogenesis of an epithelial sheet)|go:"GO:0003382"(epithelial cell morphogenesis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004706"(JUN kinase kinase kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007254"(JNK cascade)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008432"(JUN kinase binding)|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0016020"(membrane)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0031434"(mitogen-activated protein kinase kinase binding)|go:"GO:0031941"(filamentous actin)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0042060"(wound healing)|go:"GO:0043010"(camera-type eye development)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046625"(sphingolipid binding)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050434"(positive regulation of viral transcription)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0061029"(eyelid development in camera-type eye)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|reactome:R-RNO-166058|reactome:R-RNO-2871796|reactome:R-RNO-975138|reactome:R-RNO-975871|interpro:IPR011989(Armadillo-like helical)|mint:Q62925	refseq:NP_003339.1|dip:DIP-29829N|ensembl:ENSG00000177889(gene)|ensembl:ENST00000318066(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000729"(DNA double-strand break processing)|go:"GO:0001650"(fibrillar center)|go:"GO:0003723"(RNA binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006282"(regulation of DNA repair)|go:"GO:0006301"(postreplication repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016574"(histone ubiquitination)|go:"GO:0031058"(positive regulation of histone modification)|go:"GO:0031372"(UBC13-MMS2 complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033182"(regulation of histone ubiquitination)|go:"GO:0035370"(UBC13-UEV1A complex)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0061631"(ubiquitin conjugating enzyme activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070534"(protein K63-linked ubiquitination)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|interpro:IPR023313|rcsb pdb:1J7D|rcsb pdb:2C2V|rcsb pdb:3HCT|rcsb pdb:3HCU|rcsb pdb:3VON|rcsb pdb:3W31|rcsb pdb:4DHI|rcsb pdb:4DHJ|rcsb pdb:4DHZ|rcsb pdb:4IP3|rcsb pdb:4NR3|rcsb pdb:4NRG|rcsb pdb:4NRI|rcsb pdb:4ONL|rcsb pdb:4ONM|rcsb pdb:4ONN|rcsb pdb:4ORH|rcsb pdb:4TKP|rcsb pdb:4WHV|rcsb pdb:5AIT|rcsb pdb:5AIU|rcsb pdb:5EYA|rcsb pdb:5H7S|rcsb pdb:5VNZ|rcsb pdb:5VO0|rcsb pdb:5YWR|rcsb pdb:6D6I|rcsb pdb:6JKY|rcsb pdb:6KFP|rcsb pdb:6KG6|rcsb pdb:6KL4|rcsb pdb:6LP2|rcsb pdb:6P5B|rcsb pdb:6S53|reactome:R-HSA-168927|reactome:R-HSA-202424|reactome:R-HSA-2871837|reactome:R-HSA-445989|reactome:R-HSA-450302|reactome:R-HSA-450321|reactome:R-HSA-5607764|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-5696395|reactome:R-HSA-69473|reactome:R-HSA-8866654|reactome:R-HSA-9020702|reactome:R-HSA-937039|reactome:R-HSA-937041|reactome:R-HSA-9646399|reactome:R-HSA-975110|reactome:R-HSA-975144|reactome:R-HSA-983168|rcsb pdb:6ULH|rcsb pdb:6UMP|rcsb pdb:6UMS|rcsb pdb:7BBD|rcsb pdb:7BBF|rcsb pdb:7BXG|reactome:R-HSA-1169408|reactome:R-HSA-168638	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S3|resulting-ptm:Q15750 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:EwhjYjowkZIAt4UyPcZBUtf9uak10116	rogid:dqdszHlq5FLPHC6UWX6uvkC6Yz89606	intact-crc:5CC6A3DF5966BFBF|rigid:FhGUf1R51RDJrQ0DSQjYaNcxjQ0	false	sufficient binding region:433-481(IPR013083)	his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q62925	uniprotkb:Q5BJF6	intact:EBI-636664	intact:EBI-8744243|uniprotkb:B1AND3|uniprotkb:B4DRK4|uniprotkb:B4DX73|uniprotkb:B4DZ02|uniprotkb:E7EWL2|uniprotkb:F5H6J4|uniprotkb:O14721|uniprotkb:O60631|uniprotkb:Q1W2J6|uniprotkb:Q6UN26|uniprotkb:Q7Z5I6|uniprotkb:Q96FN2|ensembl:ENSP00000403453|ensembl:ENSP00000473949	psi-mi:m3k1_rat(display_long)|uniprotkb:MAPK/ERK kinase kinase 1(gene name synonym)|uniprotkb:Map3k1(gene name)|psi-mi:Map3k1(display_short)|uniprotkb:Mekk(gene name synonym)|uniprotkb:Mekk1(gene name synonym)	psi-mi:odfp2_human(display_long)|uniprotkb:ODF2(gene name)|psi-mi:ODF2(display_short)|uniprotkb:Cenexin(gene name synonym)|uniprotkb:Outer dense fiber of sperm tails protein 2(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9971936|imex:IM-22822-91	author-confidence:Z-score = 3.62	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:620966|refseq:NP_446339.1|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR007527(Zinc finger, SWIM-type)|go:"GO:0000165"(MAPK cascade)|interpro:IPR016024(Armadillo-type fold)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0002011"(morphogenesis of an epithelial sheet)|go:"GO:0003382"(epithelial cell morphogenesis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004706"(JUN kinase kinase kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007254"(JNK cascade)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008432"(JUN kinase binding)|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0016020"(membrane)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0031434"(mitogen-activated protein kinase kinase binding)|go:"GO:0031941"(filamentous actin)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0042060"(wound healing)|go:"GO:0043010"(camera-type eye development)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046625"(sphingolipid binding)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050434"(positive regulation of viral transcription)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0061029"(eyelid development in camera-type eye)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|reactome:R-RNO-166058|reactome:R-RNO-2871796|reactome:R-RNO-975138|reactome:R-RNO-975871|interpro:IPR011989(Armadillo-like helical)|mint:Q62925	refseq:XP_016870261.1|refseq:XP_016870262.1|refseq:XP_016870263.1|refseq:NP_001229281.1|refseq:NP_001229282.1|refseq:NP_001229283.1|refseq:NP_002531.3|refseq:NP_702911.1|refseq:NP_702913.1|refseq:NP_702914.1|refseq:NP_702915.1|refseq:XP_006717189.1|ensembl:ENSG00000136811(gene)|ensembl:ENST00000434106(transcript)|ensembl:ENST00000604420(transcript)|go:"GO:0000922"(spindle pole)|go:"GO:0001520"(outer dense fiber)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005634"(nucleus)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005929"(cilium)|go:"GO:0007286"(spermatid development)|go:"GO:0008104"(protein localization)|go:"GO:0010457"(centriole-centriole cohesion)|go:"GO:0031267"(small GTPase binding)|go:"GO:0036064"(ciliary basal body)|go:"GO:0036126"(sperm flagellum)|go:"GO:0044782"(cilium organization)|go:"GO:0097539"(ciliary transition fiber)|go:"GO:0120103"(centriolar subdistal appendage)|go:"GO:1902017"(regulation of cilium assembly)|interpro:IPR026099|reactome:R-HSA-2565942|reactome:R-HSA-380259|reactome:R-HSA-380270|reactome:R-HSA-380284|reactome:R-HSA-380320|reactome:R-HSA-5620912|reactome:R-HSA-8854518|refseq:NP_702910.1|refseq:XP_016870264.1|refseq:XP_016870265.1|refseq:XP_016870266.1	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S3|resulting-ptm:Q5BJF6 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:EwhjYjowkZIAt4UyPcZBUtf9uak10116	rogid:JE/npl8sp9LQO2qRFeMMAUEJgxE9606	intact-crc:20D9E598528645FF|rigid:1aknbm/SVT4QPpWCJjGB1drYUhE	false	sufficient binding region:433-481(IPR013083)	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q62925	uniprotkb:Q13404	intact:EBI-636664	intact:EBI-1050671|uniprotkb:Q13403|uniprotkb:Q13532|uniprotkb:Q96H34|uniprotkb:Q9GZT0|uniprotkb:Q9GZW1|uniprotkb:Q9H4J3|uniprotkb:Q9H4J4|uniprotkb:Q9UKL1|uniprotkb:Q9UM48|uniprotkb:Q9UM49|uniprotkb:Q9UM50|uniprotkb:Q5TGE3|uniprotkb:E1P629|uniprotkb:Q5TGE0|ensembl:ENSP00000360739	psi-mi:m3k1_rat(display_long)|uniprotkb:MAPK/ERK kinase kinase 1(gene name synonym)|uniprotkb:Map3k1(gene name)|psi-mi:Map3k1(display_short)|uniprotkb:Mekk(gene name synonym)|uniprotkb:Mekk1(gene name synonym)	psi-mi:ub2v1_human(display_long)|uniprotkb:CROC-1(gene name synonym)|uniprotkb:TRAF6-regulated IKK activator 1 beta Uev1A(gene name synonym)|uniprotkb:P/OKcl.19(orf name)|uniprotkb:UBE2V1(gene name)|psi-mi:UBE2V1(display_short)|uniprotkb:CROC1(gene name synonym)|uniprotkb:UBE2V(gene name synonym)|uniprotkb:UEV1(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9971936|imex:IM-22822-91	author-confidence:Z-score = 3.62	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:620966|refseq:NP_446339.1|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR007527(Zinc finger, SWIM-type)|go:"GO:0000165"(MAPK cascade)|interpro:IPR016024(Armadillo-type fold)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0002011"(morphogenesis of an epithelial sheet)|go:"GO:0003382"(epithelial cell morphogenesis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004706"(JUN kinase kinase kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007254"(JNK cascade)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008432"(JUN kinase binding)|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0016020"(membrane)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0031434"(mitogen-activated protein kinase kinase binding)|go:"GO:0031941"(filamentous actin)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0042060"(wound healing)|go:"GO:0043010"(camera-type eye development)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046625"(sphingolipid binding)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050434"(positive regulation of viral transcription)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0061029"(eyelid development in camera-type eye)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|reactome:R-RNO-166058|reactome:R-RNO-2871796|reactome:R-RNO-975138|reactome:R-RNO-975871|interpro:IPR011989(Armadillo-like helical)|mint:Q62925	refseq:NP_001027459.1|refseq:NP_068823.2|refseq:NP_071887.1|refseq:NP_954595.1|refseq:NP_954673.1|refseq:NP_001244322.1|refseq:NP_001244323.1|refseq:NP_001244325.1|ensembl:ENSG00000244687(gene)|ensembl:ENST00000371674(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006282"(regulation of DNA repair)|go:"GO:0006301"(postreplication repair)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0030154"(cell differentiation)|go:"GO:0031371"(ubiquitin conjugating enzyme complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035370"(UBC13-UEV1A complex)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070534"(protein K63-linked ubiquitination)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|rcsb pdb:2A4D|rcsb pdb:2C2V|rcsb pdb:2HLW|rcsb pdb:6D6I|reactome:R-HSA-168638|reactome:R-HSA-168927|reactome:R-HSA-202424|reactome:R-HSA-2871837|reactome:R-HSA-445989|reactome:R-HSA-450302|reactome:R-HSA-450321|reactome:R-HSA-5607764|reactome:R-HSA-9020702|reactome:R-HSA-937039|reactome:R-HSA-937041|reactome:R-HSA-9646399|reactome:R-HSA-975110|reactome:R-HSA-975144|reactome:R-HSA-983168|dip:DIP-41911N	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S3|resulting-ptm:Q5BJF6 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:EwhjYjowkZIAt4UyPcZBUtf9uak10116	rogid:x95N7Dj2KIqu5gySX59xLmfthUg9606	intact-crc:20D9E598528645FF|rigid:1aknbm/SVT4QPpWCJjGB1drYUhE	false	sufficient binding region:433-481(IPR013083)	his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q62925	uniprotkb:P22314	intact:EBI-636664	intact:EBI-709688|uniprotkb:Q96E13|uniprotkb:Q5JRR8|ensembl:ENSP00000338413|ensembl:ENSP00000366568	psi-mi:m3k1_rat(display_long)|uniprotkb:MAPK/ERK kinase kinase 1(gene name synonym)|uniprotkb:Map3k1(gene name)|psi-mi:Map3k1(display_short)|uniprotkb:Mekk(gene name synonym)|uniprotkb:Mekk1(gene name synonym)	psi-mi:uba1_human(display_long)|uniprotkb:Ubiquitin-activating enzyme E1(gene name synonym)|uniprotkb:Protein A1S9(gene name synonym)|uniprotkb:UBA1(gene name)|psi-mi:UBA1(display_short)|uniprotkb:A1S9T(gene name synonym)|uniprotkb:UBE1(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9971936|imex:IM-22822-91	author-confidence:Z-score = 3.62	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:620966|refseq:NP_446339.1|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR007527(Zinc finger, SWIM-type)|go:"GO:0000165"(MAPK cascade)|interpro:IPR016024(Armadillo-type fold)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0002011"(morphogenesis of an epithelial sheet)|go:"GO:0003382"(epithelial cell morphogenesis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004706"(JUN kinase kinase kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007254"(JNK cascade)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008432"(JUN kinase binding)|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0016020"(membrane)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0031434"(mitogen-activated protein kinase kinase binding)|go:"GO:0031941"(filamentous actin)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0042060"(wound healing)|go:"GO:0043010"(camera-type eye development)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046625"(sphingolipid binding)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050434"(positive regulation of viral transcription)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0061029"(eyelid development in camera-type eye)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|reactome:R-RNO-166058|reactome:R-RNO-2871796|reactome:R-RNO-975138|reactome:R-RNO-975871|interpro:IPR011989(Armadillo-like helical)|mint:Q62925	refseq:NP_003325.2|refseq:NP_695012.1|refseq:XP_016885269.1|refseq:XP_016885270.1|dip:DIP-33686N|ensembl:ENSG00000130985(gene)|ensembl:ENST00000335972(transcript)|ensembl:ENST00000377351(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0004839"(ubiquitin activating enzyme activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0032446"(protein modification by small protein conjugation)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000011(Ubiquitin-activating enzyme, E1)|interpro:IPR000594(UBA/THIF-type NAD/FAD binding fold)|interpro:IPR018074|interpro:IPR018075|interpro:IPR018965|interpro:IPR019572|interpro:IPR032418|interpro:IPR032420|interpro:IPR033127|interpro:IPR035985|interpro:IPR038252|interpro:IPR042063|interpro:IPR042302|interpro:IPR042449|mint:P22314|rcsb pdb:4P22|rcsb pdb:6DC6|reactome:R-HSA-8866652|reactome:R-HSA-983168	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S3|resulting-ptm:Q5BJF6 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:EwhjYjowkZIAt4UyPcZBUtf9uak10116	rogid:q+vEeA0XLST0Zz173bmEt0dNbDE9606	intact-crc:20D9E598528645FF|rigid:1aknbm/SVT4QPpWCJjGB1drYUhE	false	sufficient binding region:433-481(IPR013083)	his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q62925	uniprotkb:P61088	intact:EBI-636664	intact:EBI-1052908|uniprotkb:Q16781|uniprotkb:Q53Y81|ensembl:ENSP00000316176	psi-mi:m3k1_rat(display_long)|uniprotkb:MAPK/ERK kinase kinase 1(gene name synonym)|uniprotkb:Map3k1(gene name)|psi-mi:Map3k1(display_short)|uniprotkb:Mekk(gene name synonym)|uniprotkb:Mekk1(gene name synonym)	psi-mi:ube2n_human(display_long)|uniprotkb:Ubiquitin-protein ligase N(gene name synonym)|uniprotkb:Ubiquitin carrier protein N(gene name synonym)|uniprotkb:Ubc13(gene name synonym)|uniprotkb:Bendless-like ubiquitin-conjugating enzyme(gene name synonym)|uniprotkb:UBE2N(gene name)|psi-mi:UBE2N(display_short)|uniprotkb:BLU(gene name synonym)|uniprotkb:UbcH13(gene name synonym)|uniprotkb:E2 ubiquitin-conjugating enzyme N(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9971936|imex:IM-22822-91	author-confidence:Z-score = 3.62	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:620966|refseq:NP_446339.1|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR007527(Zinc finger, SWIM-type)|go:"GO:0000165"(MAPK cascade)|interpro:IPR016024(Armadillo-type fold)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0002011"(morphogenesis of an epithelial sheet)|go:"GO:0003382"(epithelial cell morphogenesis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004706"(JUN kinase kinase kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007254"(JNK cascade)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008432"(JUN kinase binding)|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0016020"(membrane)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0031434"(mitogen-activated protein kinase kinase binding)|go:"GO:0031941"(filamentous actin)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0042060"(wound healing)|go:"GO:0043010"(camera-type eye development)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046625"(sphingolipid binding)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050434"(positive regulation of viral transcription)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0061029"(eyelid development in camera-type eye)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|reactome:R-RNO-166058|reactome:R-RNO-2871796|reactome:R-RNO-975138|reactome:R-RNO-975871|interpro:IPR011989(Armadillo-like helical)|mint:Q62925	refseq:NP_003339.1|dip:DIP-29829N|ensembl:ENSG00000177889(gene)|ensembl:ENST00000318066(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000729"(DNA double-strand break processing)|go:"GO:0001650"(fibrillar center)|go:"GO:0003723"(RNA binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006282"(regulation of DNA repair)|go:"GO:0006301"(postreplication repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016574"(histone ubiquitination)|go:"GO:0031058"(positive regulation of histone modification)|go:"GO:0031372"(UBC13-MMS2 complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033182"(regulation of histone ubiquitination)|go:"GO:0035370"(UBC13-UEV1A complex)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0061631"(ubiquitin conjugating enzyme activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070534"(protein K63-linked ubiquitination)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|interpro:IPR023313|rcsb pdb:1J7D|rcsb pdb:2C2V|rcsb pdb:3HCT|rcsb pdb:3HCU|rcsb pdb:3VON|rcsb pdb:3W31|rcsb pdb:4DHI|rcsb pdb:4DHJ|rcsb pdb:4DHZ|rcsb pdb:4IP3|rcsb pdb:4NR3|rcsb pdb:4NRG|rcsb pdb:4NRI|rcsb pdb:4ONL|rcsb pdb:4ONM|rcsb pdb:4ONN|rcsb pdb:4ORH|rcsb pdb:4TKP|rcsb pdb:4WHV|rcsb pdb:5AIT|rcsb pdb:5AIU|rcsb pdb:5EYA|rcsb pdb:5H7S|rcsb pdb:5VNZ|rcsb pdb:5VO0|rcsb pdb:5YWR|rcsb pdb:6D6I|rcsb pdb:6JKY|rcsb pdb:6KFP|rcsb pdb:6KG6|rcsb pdb:6KL4|rcsb pdb:6LP2|rcsb pdb:6P5B|rcsb pdb:6S53|reactome:R-HSA-168927|reactome:R-HSA-202424|reactome:R-HSA-2871837|reactome:R-HSA-445989|reactome:R-HSA-450302|reactome:R-HSA-450321|reactome:R-HSA-5607764|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-5696395|reactome:R-HSA-69473|reactome:R-HSA-8866654|reactome:R-HSA-9020702|reactome:R-HSA-937039|reactome:R-HSA-937041|reactome:R-HSA-9646399|reactome:R-HSA-975110|reactome:R-HSA-975144|reactome:R-HSA-983168|rcsb pdb:6ULH|rcsb pdb:6UMP|rcsb pdb:6UMS|rcsb pdb:7BBD|rcsb pdb:7BBF|rcsb pdb:7BXG|reactome:R-HSA-1169408|reactome:R-HSA-168638	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S3|resulting-ptm:Q5BJF6 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:EwhjYjowkZIAt4UyPcZBUtf9uak10116	rogid:dqdszHlq5FLPHC6UWX6uvkC6Yz89606	intact-crc:20D9E598528645FF|rigid:1aknbm/SVT4QPpWCJjGB1drYUhE	false	sufficient binding region:433-481(IPR013083)	his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q62925	uniprotkb:Q13404	intact:EBI-636664	intact:EBI-1050671|uniprotkb:Q13403|uniprotkb:Q13532|uniprotkb:Q96H34|uniprotkb:Q9GZT0|uniprotkb:Q9GZW1|uniprotkb:Q9H4J3|uniprotkb:Q9H4J4|uniprotkb:Q9UKL1|uniprotkb:Q9UM48|uniprotkb:Q9UM49|uniprotkb:Q9UM50|uniprotkb:Q5TGE3|uniprotkb:E1P629|uniprotkb:Q5TGE0|ensembl:ENSP00000360739	psi-mi:m3k1_rat(display_long)|uniprotkb:MAPK/ERK kinase kinase 1(gene name synonym)|uniprotkb:Map3k1(gene name)|psi-mi:Map3k1(display_short)|uniprotkb:Mekk(gene name synonym)|uniprotkb:Mekk1(gene name synonym)	psi-mi:ub2v1_human(display_long)|uniprotkb:CROC-1(gene name synonym)|uniprotkb:TRAF6-regulated IKK activator 1 beta Uev1A(gene name synonym)|uniprotkb:P/OKcl.19(orf name)|uniprotkb:UBE2V1(gene name)|psi-mi:UBE2V1(display_short)|uniprotkb:CROC1(gene name synonym)|uniprotkb:UBE2V(gene name synonym)|uniprotkb:UEV1(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9971961|imex:IM-22822-92	author-confidence:Z-score = 4.78	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:620966|refseq:NP_446339.1|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR007527(Zinc finger, SWIM-type)|go:"GO:0000165"(MAPK cascade)|interpro:IPR016024(Armadillo-type fold)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0002011"(morphogenesis of an epithelial sheet)|go:"GO:0003382"(epithelial cell morphogenesis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004706"(JUN kinase kinase kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007254"(JNK cascade)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008432"(JUN kinase binding)|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0016020"(membrane)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0031434"(mitogen-activated protein kinase kinase binding)|go:"GO:0031941"(filamentous actin)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0042060"(wound healing)|go:"GO:0043010"(camera-type eye development)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046625"(sphingolipid binding)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050434"(positive regulation of viral transcription)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0061029"(eyelid development in camera-type eye)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|reactome:R-RNO-166058|reactome:R-RNO-2871796|reactome:R-RNO-975138|reactome:R-RNO-975871|interpro:IPR011989(Armadillo-like helical)|mint:Q62925	refseq:NP_001027459.1|refseq:NP_068823.2|refseq:NP_071887.1|refseq:NP_954595.1|refseq:NP_954673.1|refseq:NP_001244322.1|refseq:NP_001244323.1|refseq:NP_001244325.1|ensembl:ENSG00000244687(gene)|ensembl:ENST00000371674(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006282"(regulation of DNA repair)|go:"GO:0006301"(postreplication repair)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0030154"(cell differentiation)|go:"GO:0031371"(ubiquitin conjugating enzyme complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035370"(UBC13-UEV1A complex)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070534"(protein K63-linked ubiquitination)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|rcsb pdb:2A4D|rcsb pdb:2C2V|rcsb pdb:2HLW|rcsb pdb:6D6I|reactome:R-HSA-168638|reactome:R-HSA-168927|reactome:R-HSA-202424|reactome:R-HSA-2871837|reactome:R-HSA-445989|reactome:R-HSA-450302|reactome:R-HSA-450321|reactome:R-HSA-5607764|reactome:R-HSA-9020702|reactome:R-HSA-937039|reactome:R-HSA-937041|reactome:R-HSA-9646399|reactome:R-HSA-975110|reactome:R-HSA-975144|reactome:R-HSA-983168|dip:DIP-41911N	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S3|resulting-ptm:Q6NZX9 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2015/01/17	rogid:EwhjYjowkZIAt4UyPcZBUtf9uak10116	rogid:x95N7Dj2KIqu5gySX59xLmfthUg9606	intact-crc:EE1E0177CA899FD7|rigid:+/ICLP2wRUOmJboXkIUcHw0m3Fk	false	sufficient binding region:433-481(IPR013083)	his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q62925	uniprotkb:P22314	intact:EBI-636664	intact:EBI-709688|uniprotkb:Q96E13|uniprotkb:Q5JRR8|ensembl:ENSP00000338413|ensembl:ENSP00000366568	psi-mi:m3k1_rat(display_long)|uniprotkb:MAPK/ERK kinase kinase 1(gene name synonym)|uniprotkb:Map3k1(gene name)|psi-mi:Map3k1(display_short)|uniprotkb:Mekk(gene name synonym)|uniprotkb:Mekk1(gene name synonym)	psi-mi:uba1_human(display_long)|uniprotkb:Ubiquitin-activating enzyme E1(gene name synonym)|uniprotkb:Protein A1S9(gene name synonym)|uniprotkb:UBA1(gene name)|psi-mi:UBA1(display_short)|uniprotkb:A1S9T(gene name synonym)|uniprotkb:UBE1(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9971961|imex:IM-22822-92	author-confidence:Z-score = 4.78	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:620966|refseq:NP_446339.1|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR007527(Zinc finger, SWIM-type)|go:"GO:0000165"(MAPK cascade)|interpro:IPR016024(Armadillo-type fold)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0002011"(morphogenesis of an epithelial sheet)|go:"GO:0003382"(epithelial cell morphogenesis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004706"(JUN kinase kinase kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007254"(JNK cascade)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008432"(JUN kinase binding)|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0016020"(membrane)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0031434"(mitogen-activated protein kinase kinase binding)|go:"GO:0031941"(filamentous actin)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0042060"(wound healing)|go:"GO:0043010"(camera-type eye development)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046625"(sphingolipid binding)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050434"(positive regulation of viral transcription)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0061029"(eyelid development in camera-type eye)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|reactome:R-RNO-166058|reactome:R-RNO-2871796|reactome:R-RNO-975138|reactome:R-RNO-975871|interpro:IPR011989(Armadillo-like helical)|mint:Q62925	refseq:NP_003325.2|refseq:NP_695012.1|refseq:XP_016885269.1|refseq:XP_016885270.1|dip:DIP-33686N|ensembl:ENSG00000130985(gene)|ensembl:ENST00000335972(transcript)|ensembl:ENST00000377351(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0004839"(ubiquitin activating enzyme activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0032446"(protein modification by small protein conjugation)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000011(Ubiquitin-activating enzyme, E1)|interpro:IPR000594(UBA/THIF-type NAD/FAD binding fold)|interpro:IPR018074|interpro:IPR018075|interpro:IPR018965|interpro:IPR019572|interpro:IPR032418|interpro:IPR032420|interpro:IPR033127|interpro:IPR035985|interpro:IPR038252|interpro:IPR042063|interpro:IPR042302|interpro:IPR042449|mint:P22314|rcsb pdb:4P22|rcsb pdb:6DC6|reactome:R-HSA-8866652|reactome:R-HSA-983168	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S3|resulting-ptm:Q6NZX9 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2015/01/17	rogid:EwhjYjowkZIAt4UyPcZBUtf9uak10116	rogid:q+vEeA0XLST0Zz173bmEt0dNbDE9606	intact-crc:EE1E0177CA899FD7|rigid:+/ICLP2wRUOmJboXkIUcHw0m3Fk	false	sufficient binding region:433-481(IPR013083)	his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q62925	uniprotkb:P61088	intact:EBI-636664	intact:EBI-1052908|uniprotkb:Q16781|uniprotkb:Q53Y81|ensembl:ENSP00000316176	psi-mi:m3k1_rat(display_long)|uniprotkb:MAPK/ERK kinase kinase 1(gene name synonym)|uniprotkb:Map3k1(gene name)|psi-mi:Map3k1(display_short)|uniprotkb:Mekk(gene name synonym)|uniprotkb:Mekk1(gene name synonym)	psi-mi:ube2n_human(display_long)|uniprotkb:Ubiquitin-protein ligase N(gene name synonym)|uniprotkb:Ubiquitin carrier protein N(gene name synonym)|uniprotkb:Ubc13(gene name synonym)|uniprotkb:Bendless-like ubiquitin-conjugating enzyme(gene name synonym)|uniprotkb:UBE2N(gene name)|psi-mi:UBE2N(display_short)|uniprotkb:BLU(gene name synonym)|uniprotkb:UbcH13(gene name synonym)|uniprotkb:E2 ubiquitin-conjugating enzyme N(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9971961|imex:IM-22822-92	author-confidence:Z-score = 4.78	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:620966|refseq:NP_446339.1|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR007527(Zinc finger, SWIM-type)|go:"GO:0000165"(MAPK cascade)|interpro:IPR016024(Armadillo-type fold)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0002011"(morphogenesis of an epithelial sheet)|go:"GO:0003382"(epithelial cell morphogenesis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004706"(JUN kinase kinase kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007254"(JNK cascade)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008432"(JUN kinase binding)|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0016020"(membrane)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0031434"(mitogen-activated protein kinase kinase binding)|go:"GO:0031941"(filamentous actin)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0042060"(wound healing)|go:"GO:0043010"(camera-type eye development)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046625"(sphingolipid binding)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050434"(positive regulation of viral transcription)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0061029"(eyelid development in camera-type eye)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|reactome:R-RNO-166058|reactome:R-RNO-2871796|reactome:R-RNO-975138|reactome:R-RNO-975871|interpro:IPR011989(Armadillo-like helical)|mint:Q62925	refseq:NP_003339.1|dip:DIP-29829N|ensembl:ENSG00000177889(gene)|ensembl:ENST00000318066(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000729"(DNA double-strand break processing)|go:"GO:0001650"(fibrillar center)|go:"GO:0003723"(RNA binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006282"(regulation of DNA repair)|go:"GO:0006301"(postreplication repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016574"(histone ubiquitination)|go:"GO:0031058"(positive regulation of histone modification)|go:"GO:0031372"(UBC13-MMS2 complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033182"(regulation of histone ubiquitination)|go:"GO:0035370"(UBC13-UEV1A complex)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0061631"(ubiquitin conjugating enzyme activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070534"(protein K63-linked ubiquitination)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|interpro:IPR023313|rcsb pdb:1J7D|rcsb pdb:2C2V|rcsb pdb:3HCT|rcsb pdb:3HCU|rcsb pdb:3VON|rcsb pdb:3W31|rcsb pdb:4DHI|rcsb pdb:4DHJ|rcsb pdb:4DHZ|rcsb pdb:4IP3|rcsb pdb:4NR3|rcsb pdb:4NRG|rcsb pdb:4NRI|rcsb pdb:4ONL|rcsb pdb:4ONM|rcsb pdb:4ONN|rcsb pdb:4ORH|rcsb pdb:4TKP|rcsb pdb:4WHV|rcsb pdb:5AIT|rcsb pdb:5AIU|rcsb pdb:5EYA|rcsb pdb:5H7S|rcsb pdb:5VNZ|rcsb pdb:5VO0|rcsb pdb:5YWR|rcsb pdb:6D6I|rcsb pdb:6JKY|rcsb pdb:6KFP|rcsb pdb:6KG6|rcsb pdb:6KL4|rcsb pdb:6LP2|rcsb pdb:6P5B|rcsb pdb:6S53|reactome:R-HSA-168927|reactome:R-HSA-202424|reactome:R-HSA-2871837|reactome:R-HSA-445989|reactome:R-HSA-450302|reactome:R-HSA-450321|reactome:R-HSA-5607764|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-5696395|reactome:R-HSA-69473|reactome:R-HSA-8866654|reactome:R-HSA-9020702|reactome:R-HSA-937039|reactome:R-HSA-937041|reactome:R-HSA-9646399|reactome:R-HSA-975110|reactome:R-HSA-975144|reactome:R-HSA-983168|rcsb pdb:6ULH|rcsb pdb:6UMP|rcsb pdb:6UMS|rcsb pdb:7BBD|rcsb pdb:7BBF|rcsb pdb:7BXG|reactome:R-HSA-1169408|reactome:R-HSA-168638	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S3|resulting-ptm:Q6NZX9 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2015/01/17	rogid:EwhjYjowkZIAt4UyPcZBUtf9uak10116	rogid:dqdszHlq5FLPHC6UWX6uvkC6Yz89606	intact-crc:EE1E0177CA899FD7|rigid:+/ICLP2wRUOmJboXkIUcHw0m3Fk	false	sufficient binding region:433-481(IPR013083)	his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q62925	uniprotkb:Q96RU2	intact:EBI-636664	intact:EBI-2512342|ensembl:ENSP00000003302|uniprotkb:B0YJC0|uniprotkb:B0YJC1|uniprotkb:Q9P213|intact:EBI-2796288|uniprotkb:Q6NZX9	psi-mi:m3k1_rat(display_long)|uniprotkb:MAPK/ERK kinase kinase 1(gene name synonym)|uniprotkb:Map3k1(gene name)|psi-mi:Map3k1(display_short)|uniprotkb:Mekk(gene name synonym)|uniprotkb:Mekk1(gene name synonym)	psi-mi:ubp28_human(display_long)|uniprotkb:USP28(gene name)|psi-mi:USP28(display_short)|uniprotkb:KIAA1515(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 28(gene name synonym)|uniprotkb:Deubiquitinating enzyme 28(gene name synonym)|uniprotkb:Ubiquitin thioesterase 28(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9971961|imex:IM-22822-92	author-confidence:Z-score = 4.78	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:620966|refseq:NP_446339.1|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR007527(Zinc finger, SWIM-type)|go:"GO:0000165"(MAPK cascade)|interpro:IPR016024(Armadillo-type fold)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0002011"(morphogenesis of an epithelial sheet)|go:"GO:0003382"(epithelial cell morphogenesis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004706"(JUN kinase kinase kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007254"(JNK cascade)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008432"(JUN kinase binding)|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0016020"(membrane)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0031434"(mitogen-activated protein kinase kinase binding)|go:"GO:0031941"(filamentous actin)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0042060"(wound healing)|go:"GO:0043010"(camera-type eye development)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046625"(sphingolipid binding)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050434"(positive regulation of viral transcription)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0061029"(eyelid development in camera-type eye)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|reactome:R-RNO-166058|reactome:R-RNO-2871796|reactome:R-RNO-975138|reactome:R-RNO-975871|interpro:IPR011989(Armadillo-like helical)|mint:Q62925	ensembl:ENSG00000048028(gene)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0008283"(cell population proliferation)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0016604"(nuclear body)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034644"(cellular response to UV)|go:"GO:0042771"(intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR009060(UBA-like)|interpro:IPR018200|interpro:IPR028889|interpro:IPR038765|mint:Q96RU2|rcsb pdb:2LVA|rcsb pdb:2MUU|rcsb pdb:6H4H|rcsb pdb:6H4I|rcsb pdb:6HEH|rcsb pdb:6HEI|rcsb pdb:6HEJ|rcsb pdb:6HEK|reactome:R-HSA-5689880|ensembl:ENST00000003302(transcript)|go:"GO:0000077"(DNA damage checkpoint signaling)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|refseq:NP_065937.1|refseq:NP_001333187.1|refseq:NP_001333202.1	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S3|resulting-ptm:Q6NZX9 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2015/01/17	rogid:EwhjYjowkZIAt4UyPcZBUtf9uak10116	rogid:axlPKHiS0KlPbl2dNx2h12/LtY09606	intact-crc:EE1E0177CA899FD7|rigid:+/ICLP2wRUOmJboXkIUcHw0m3Fk	false	sufficient binding region:433-481(IPR013083)	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q6P2H3	uniprotkb:Q62925	intact:EBI-2808308|ensembl:ENSP00000252992|uniprotkb:Q5VY68|uniprotkb:Q9H828|uniprotkb:Q9H6Q1|uniprotkb:Q5VY70|uniprotkb:Q9UF52|uniprotkb:D3DPK4|uniprotkb:B4DRL1|uniprotkb:F8W7K4	intact:EBI-636664	psi-mi:cep85_human(display_long)|uniprotkb:CCDC21(gene name synonym)|uniprotkb:Coiled-coil domain-containing protein 21(gene name synonym)|uniprotkb:CEP85(gene name)|psi-mi:CEP85(display_short)	psi-mi:m3k1_rat(display_long)|uniprotkb:MAPK/ERK kinase kinase 1(gene name synonym)|uniprotkb:Map3k1(gene name)|psi-mi:Map3k1(display_short)|uniprotkb:Mekk(gene name synonym)|uniprotkb:Mekk1(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9971986|imex:IM-22822-93	author-confidence:Z-score = 5.83	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000130695(gene)|ensembl:ENST00000252992(transcript)|go:"GO:0000242"(pericentriolar material)|go:"GO:0000922"(spindle pole)|go:"GO:0005730"(nucleolus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0007059"(chromosome segregation)|go:"GO:0046602"(regulation of mitotic centrosome separation)|interpro:IPR029777|interpro:IPR040210|rcsb pdb:5OI7|rcsb pdb:5OID|refseq:NP_001306873.1|refseq:NP_073615.2|refseq:NP_001268446.1|refseq:NP_001268447.1	rgd:620966|refseq:NP_446339.1|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR007527(Zinc finger, SWIM-type)|go:"GO:0000165"(MAPK cascade)|interpro:IPR016024(Armadillo-type fold)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0002011"(morphogenesis of an epithelial sheet)|go:"GO:0003382"(epithelial cell morphogenesis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004706"(JUN kinase kinase kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007254"(JNK cascade)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008432"(JUN kinase binding)|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0016020"(membrane)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0031434"(mitogen-activated protein kinase kinase binding)|go:"GO:0031941"(filamentous actin)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0042060"(wound healing)|go:"GO:0043010"(camera-type eye development)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046625"(sphingolipid binding)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050434"(positive regulation of viral transcription)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0061029"(eyelid development in camera-type eye)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|reactome:R-RNO-166058|reactome:R-RNO-2871796|reactome:R-RNO-975138|reactome:R-RNO-975871|interpro:IPR011989(Armadillo-like helical)|mint:Q62925	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S3|resulting-ptm:Q6P2H3 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:akTkilY7AIoc1FtkiNFwz4oelvI9606	rogid:EwhjYjowkZIAt4UyPcZBUtf9uak10116	intact-crc:B0BB7FE678F176ED|rigid:pn/sjwDjM4EgWBdcu2+ZAnHiUNs	false	-	sufficient binding region:433-481(IPR013083)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q6P2H3	uniprotkb:Q13404	intact:EBI-2808308|ensembl:ENSP00000252992|uniprotkb:Q5VY68|uniprotkb:Q9H828|uniprotkb:Q9H6Q1|uniprotkb:Q5VY70|uniprotkb:Q9UF52|uniprotkb:D3DPK4|uniprotkb:B4DRL1|uniprotkb:F8W7K4	intact:EBI-1050671|uniprotkb:Q13403|uniprotkb:Q13532|uniprotkb:Q96H34|uniprotkb:Q9GZT0|uniprotkb:Q9GZW1|uniprotkb:Q9H4J3|uniprotkb:Q9H4J4|uniprotkb:Q9UKL1|uniprotkb:Q9UM48|uniprotkb:Q9UM49|uniprotkb:Q9UM50|uniprotkb:Q5TGE3|uniprotkb:E1P629|uniprotkb:Q5TGE0|ensembl:ENSP00000360739	psi-mi:cep85_human(display_long)|uniprotkb:CCDC21(gene name synonym)|uniprotkb:Coiled-coil domain-containing protein 21(gene name synonym)|uniprotkb:CEP85(gene name)|psi-mi:CEP85(display_short)	psi-mi:ub2v1_human(display_long)|uniprotkb:CROC-1(gene name synonym)|uniprotkb:TRAF6-regulated IKK activator 1 beta Uev1A(gene name synonym)|uniprotkb:P/OKcl.19(orf name)|uniprotkb:UBE2V1(gene name)|psi-mi:UBE2V1(display_short)|uniprotkb:CROC1(gene name synonym)|uniprotkb:UBE2V(gene name synonym)|uniprotkb:UEV1(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9971986|imex:IM-22822-93	author-confidence:Z-score = 5.83	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000130695(gene)|ensembl:ENST00000252992(transcript)|go:"GO:0000242"(pericentriolar material)|go:"GO:0000922"(spindle pole)|go:"GO:0005730"(nucleolus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0007059"(chromosome segregation)|go:"GO:0046602"(regulation of mitotic centrosome separation)|interpro:IPR029777|interpro:IPR040210|rcsb pdb:5OI7|rcsb pdb:5OID|refseq:NP_001306873.1|refseq:NP_073615.2|refseq:NP_001268446.1|refseq:NP_001268447.1	refseq:NP_001027459.1|refseq:NP_068823.2|refseq:NP_071887.1|refseq:NP_954595.1|refseq:NP_954673.1|refseq:NP_001244322.1|refseq:NP_001244323.1|refseq:NP_001244325.1|ensembl:ENSG00000244687(gene)|ensembl:ENST00000371674(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006282"(regulation of DNA repair)|go:"GO:0006301"(postreplication repair)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0030154"(cell differentiation)|go:"GO:0031371"(ubiquitin conjugating enzyme complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035370"(UBC13-UEV1A complex)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070534"(protein K63-linked ubiquitination)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|rcsb pdb:2A4D|rcsb pdb:2C2V|rcsb pdb:2HLW|rcsb pdb:6D6I|reactome:R-HSA-168638|reactome:R-HSA-168927|reactome:R-HSA-202424|reactome:R-HSA-2871837|reactome:R-HSA-445989|reactome:R-HSA-450302|reactome:R-HSA-450321|reactome:R-HSA-5607764|reactome:R-HSA-9020702|reactome:R-HSA-937039|reactome:R-HSA-937041|reactome:R-HSA-9646399|reactome:R-HSA-975110|reactome:R-HSA-975144|reactome:R-HSA-983168|dip:DIP-41911N	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S3|resulting-ptm:Q6P2H3 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:akTkilY7AIoc1FtkiNFwz4oelvI9606	rogid:x95N7Dj2KIqu5gySX59xLmfthUg9606	intact-crc:B0BB7FE678F176ED|rigid:pn/sjwDjM4EgWBdcu2+ZAnHiUNs	false	-	his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q6P2H3	uniprotkb:P22314	intact:EBI-2808308|ensembl:ENSP00000252992|uniprotkb:Q5VY68|uniprotkb:Q9H828|uniprotkb:Q9H6Q1|uniprotkb:Q5VY70|uniprotkb:Q9UF52|uniprotkb:D3DPK4|uniprotkb:B4DRL1|uniprotkb:F8W7K4	intact:EBI-709688|uniprotkb:Q96E13|uniprotkb:Q5JRR8|ensembl:ENSP00000338413|ensembl:ENSP00000366568	psi-mi:cep85_human(display_long)|uniprotkb:CCDC21(gene name synonym)|uniprotkb:Coiled-coil domain-containing protein 21(gene name synonym)|uniprotkb:CEP85(gene name)|psi-mi:CEP85(display_short)	psi-mi:uba1_human(display_long)|uniprotkb:Ubiquitin-activating enzyme E1(gene name synonym)|uniprotkb:Protein A1S9(gene name synonym)|uniprotkb:UBA1(gene name)|psi-mi:UBA1(display_short)|uniprotkb:A1S9T(gene name synonym)|uniprotkb:UBE1(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9971986|imex:IM-22822-93	author-confidence:Z-score = 5.83	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000130695(gene)|ensembl:ENST00000252992(transcript)|go:"GO:0000242"(pericentriolar material)|go:"GO:0000922"(spindle pole)|go:"GO:0005730"(nucleolus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0007059"(chromosome segregation)|go:"GO:0046602"(regulation of mitotic centrosome separation)|interpro:IPR029777|interpro:IPR040210|rcsb pdb:5OI7|rcsb pdb:5OID|refseq:NP_001306873.1|refseq:NP_073615.2|refseq:NP_001268446.1|refseq:NP_001268447.1	refseq:NP_003325.2|refseq:NP_695012.1|refseq:XP_016885269.1|refseq:XP_016885270.1|dip:DIP-33686N|ensembl:ENSG00000130985(gene)|ensembl:ENST00000335972(transcript)|ensembl:ENST00000377351(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0004839"(ubiquitin activating enzyme activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0032446"(protein modification by small protein conjugation)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000011(Ubiquitin-activating enzyme, E1)|interpro:IPR000594(UBA/THIF-type NAD/FAD binding fold)|interpro:IPR018074|interpro:IPR018075|interpro:IPR018965|interpro:IPR019572|interpro:IPR032418|interpro:IPR032420|interpro:IPR033127|interpro:IPR035985|interpro:IPR038252|interpro:IPR042063|interpro:IPR042302|interpro:IPR042449|mint:P22314|rcsb pdb:4P22|rcsb pdb:6DC6|reactome:R-HSA-8866652|reactome:R-HSA-983168	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S3|resulting-ptm:Q6P2H3 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:akTkilY7AIoc1FtkiNFwz4oelvI9606	rogid:q+vEeA0XLST0Zz173bmEt0dNbDE9606	intact-crc:B0BB7FE678F176ED|rigid:pn/sjwDjM4EgWBdcu2+ZAnHiUNs	false	-	his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q6P2H3	uniprotkb:P61088	intact:EBI-2808308|ensembl:ENSP00000252992|uniprotkb:Q5VY68|uniprotkb:Q9H828|uniprotkb:Q9H6Q1|uniprotkb:Q5VY70|uniprotkb:Q9UF52|uniprotkb:D3DPK4|uniprotkb:B4DRL1|uniprotkb:F8W7K4	intact:EBI-1052908|uniprotkb:Q16781|uniprotkb:Q53Y81|ensembl:ENSP00000316176	psi-mi:cep85_human(display_long)|uniprotkb:CCDC21(gene name synonym)|uniprotkb:Coiled-coil domain-containing protein 21(gene name synonym)|uniprotkb:CEP85(gene name)|psi-mi:CEP85(display_short)	psi-mi:ube2n_human(display_long)|uniprotkb:Ubiquitin-protein ligase N(gene name synonym)|uniprotkb:Ubiquitin carrier protein N(gene name synonym)|uniprotkb:Ubc13(gene name synonym)|uniprotkb:Bendless-like ubiquitin-conjugating enzyme(gene name synonym)|uniprotkb:UBE2N(gene name)|psi-mi:UBE2N(display_short)|uniprotkb:BLU(gene name synonym)|uniprotkb:UbcH13(gene name synonym)|uniprotkb:E2 ubiquitin-conjugating enzyme N(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9971986|imex:IM-22822-93	author-confidence:Z-score = 5.83	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000130695(gene)|ensembl:ENST00000252992(transcript)|go:"GO:0000242"(pericentriolar material)|go:"GO:0000922"(spindle pole)|go:"GO:0005730"(nucleolus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0007059"(chromosome segregation)|go:"GO:0046602"(regulation of mitotic centrosome separation)|interpro:IPR029777|interpro:IPR040210|rcsb pdb:5OI7|rcsb pdb:5OID|refseq:NP_001306873.1|refseq:NP_073615.2|refseq:NP_001268446.1|refseq:NP_001268447.1	refseq:NP_003339.1|dip:DIP-29829N|ensembl:ENSG00000177889(gene)|ensembl:ENST00000318066(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000729"(DNA double-strand break processing)|go:"GO:0001650"(fibrillar center)|go:"GO:0003723"(RNA binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006282"(regulation of DNA repair)|go:"GO:0006301"(postreplication repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016574"(histone ubiquitination)|go:"GO:0031058"(positive regulation of histone modification)|go:"GO:0031372"(UBC13-MMS2 complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033182"(regulation of histone ubiquitination)|go:"GO:0035370"(UBC13-UEV1A complex)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0061631"(ubiquitin conjugating enzyme activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070534"(protein K63-linked ubiquitination)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|interpro:IPR023313|rcsb pdb:1J7D|rcsb pdb:2C2V|rcsb pdb:3HCT|rcsb pdb:3HCU|rcsb pdb:3VON|rcsb pdb:3W31|rcsb pdb:4DHI|rcsb pdb:4DHJ|rcsb pdb:4DHZ|rcsb pdb:4IP3|rcsb pdb:4NR3|rcsb pdb:4NRG|rcsb pdb:4NRI|rcsb pdb:4ONL|rcsb pdb:4ONM|rcsb pdb:4ONN|rcsb pdb:4ORH|rcsb pdb:4TKP|rcsb pdb:4WHV|rcsb pdb:5AIT|rcsb pdb:5AIU|rcsb pdb:5EYA|rcsb pdb:5H7S|rcsb pdb:5VNZ|rcsb pdb:5VO0|rcsb pdb:5YWR|rcsb pdb:6D6I|rcsb pdb:6JKY|rcsb pdb:6KFP|rcsb pdb:6KG6|rcsb pdb:6KL4|rcsb pdb:6LP2|rcsb pdb:6P5B|rcsb pdb:6S53|reactome:R-HSA-168927|reactome:R-HSA-202424|reactome:R-HSA-2871837|reactome:R-HSA-445989|reactome:R-HSA-450302|reactome:R-HSA-450321|reactome:R-HSA-5607764|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-5696395|reactome:R-HSA-69473|reactome:R-HSA-8866654|reactome:R-HSA-9020702|reactome:R-HSA-937039|reactome:R-HSA-937041|reactome:R-HSA-9646399|reactome:R-HSA-975110|reactome:R-HSA-975144|reactome:R-HSA-983168|rcsb pdb:6ULH|rcsb pdb:6UMP|rcsb pdb:6UMS|rcsb pdb:7BBD|rcsb pdb:7BBF|rcsb pdb:7BXG|reactome:R-HSA-1169408|reactome:R-HSA-168638	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S3|resulting-ptm:Q6P2H3 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:akTkilY7AIoc1FtkiNFwz4oelvI9606	rogid:dqdszHlq5FLPHC6UWX6uvkC6Yz89606	intact-crc:B0BB7FE678F176ED|rigid:pn/sjwDjM4EgWBdcu2+ZAnHiUNs	false	-	his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q6PH85	uniprotkb:Q62925	intact:EBI-9917408|uniprotkb:Q5JSA6|uniprotkb:Q9NXR6|uniprotkb:Q5JSA5|uniprotkb:Q9NVJ1|uniprotkb:Q5JSA7|ensembl:ENSP00000417706	intact:EBI-636664	psi-mi:dcnl2_human(display_long)|uniprotkb:C13orf17(gene name synonym)|uniprotkb:DCUN1 domain-containing protein 2(gene name synonym)|uniprotkb:DCUN1L2(gene name synonym)|uniprotkb:Defective in cullin neddylation protein 1-like protein 2(gene name synonym)|uniprotkb:DCUN1D2(gene name)|psi-mi:DCUN1D2(display_short)	psi-mi:m3k1_rat(display_long)|uniprotkb:MAPK/ERK kinase kinase 1(gene name synonym)|uniprotkb:Map3k1(gene name)|psi-mi:Map3k1(display_short)|uniprotkb:Mekk(gene name synonym)|uniprotkb:Mekk1(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9972011|imex:IM-22822-94	author-confidence:Z-score = 6.66	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001014305.1|dip:DIP-60768N|ensembl:ENSG00000150401(gene)|ensembl:ENST00000478244(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0031624"(ubiquitin conjugating enzyme binding)|go:"GO:0032182"(ubiquitin-like protein binding)|go:"GO:0045116"(protein neddylation)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0097602"(cullin family protein binding)|go:"GO:2000434"(regulation of protein neddylation)|go:"GO:2000436"(positive regulation of protein neddylation)|interpro:IPR005176(Protein of unknown function DUF298)|interpro:IPR009060(UBA-like)|interpro:IPR014764(Defective in cullin neddylation)|interpro:IPR042460|rcsb pdb:4GAO|reactome:R-HSA-8951664	rgd:620966|refseq:NP_446339.1|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR007527(Zinc finger, SWIM-type)|go:"GO:0000165"(MAPK cascade)|interpro:IPR016024(Armadillo-type fold)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0002011"(morphogenesis of an epithelial sheet)|go:"GO:0003382"(epithelial cell morphogenesis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004706"(JUN kinase kinase kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007254"(JNK cascade)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008432"(JUN kinase binding)|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0016020"(membrane)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0031434"(mitogen-activated protein kinase kinase binding)|go:"GO:0031941"(filamentous actin)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0042060"(wound healing)|go:"GO:0043010"(camera-type eye development)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046625"(sphingolipid binding)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050434"(positive regulation of viral transcription)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0061029"(eyelid development in camera-type eye)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|reactome:R-RNO-166058|reactome:R-RNO-2871796|reactome:R-RNO-975138|reactome:R-RNO-975871|interpro:IPR011989(Armadillo-like helical)|mint:Q62925	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S3|resulting-ptm:Q6PH85 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:3Gz33h06rkceJvO9VMHjBBtofZw9606	rogid:EwhjYjowkZIAt4UyPcZBUtf9uak10116	intact-crc:5282F910401A0C40|rigid:eP6VyFPv6+pSnCIWHPUNe8BuYao	false	-	sufficient binding region:433-481(IPR013083)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q6PH85	uniprotkb:Q13404	intact:EBI-9917408|uniprotkb:Q5JSA6|uniprotkb:Q9NXR6|uniprotkb:Q5JSA5|uniprotkb:Q9NVJ1|uniprotkb:Q5JSA7|ensembl:ENSP00000417706	intact:EBI-1050671|uniprotkb:Q13403|uniprotkb:Q13532|uniprotkb:Q96H34|uniprotkb:Q9GZT0|uniprotkb:Q9GZW1|uniprotkb:Q9H4J3|uniprotkb:Q9H4J4|uniprotkb:Q9UKL1|uniprotkb:Q9UM48|uniprotkb:Q9UM49|uniprotkb:Q9UM50|uniprotkb:Q5TGE3|uniprotkb:E1P629|uniprotkb:Q5TGE0|ensembl:ENSP00000360739	psi-mi:dcnl2_human(display_long)|uniprotkb:C13orf17(gene name synonym)|uniprotkb:DCUN1 domain-containing protein 2(gene name synonym)|uniprotkb:DCUN1L2(gene name synonym)|uniprotkb:Defective in cullin neddylation protein 1-like protein 2(gene name synonym)|uniprotkb:DCUN1D2(gene name)|psi-mi:DCUN1D2(display_short)	psi-mi:ub2v1_human(display_long)|uniprotkb:CROC-1(gene name synonym)|uniprotkb:TRAF6-regulated IKK activator 1 beta Uev1A(gene name synonym)|uniprotkb:P/OKcl.19(orf name)|uniprotkb:UBE2V1(gene name)|psi-mi:UBE2V1(display_short)|uniprotkb:CROC1(gene name synonym)|uniprotkb:UBE2V(gene name synonym)|uniprotkb:UEV1(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9972011|imex:IM-22822-94	author-confidence:Z-score = 6.66	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001014305.1|dip:DIP-60768N|ensembl:ENSG00000150401(gene)|ensembl:ENST00000478244(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0031624"(ubiquitin conjugating enzyme binding)|go:"GO:0032182"(ubiquitin-like protein binding)|go:"GO:0045116"(protein neddylation)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0097602"(cullin family protein binding)|go:"GO:2000434"(regulation of protein neddylation)|go:"GO:2000436"(positive regulation of protein neddylation)|interpro:IPR005176(Protein of unknown function DUF298)|interpro:IPR009060(UBA-like)|interpro:IPR014764(Defective in cullin neddylation)|interpro:IPR042460|rcsb pdb:4GAO|reactome:R-HSA-8951664	refseq:NP_001027459.1|refseq:NP_068823.2|refseq:NP_071887.1|refseq:NP_954595.1|refseq:NP_954673.1|refseq:NP_001244322.1|refseq:NP_001244323.1|refseq:NP_001244325.1|ensembl:ENSG00000244687(gene)|ensembl:ENST00000371674(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006282"(regulation of DNA repair)|go:"GO:0006301"(postreplication repair)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0030154"(cell differentiation)|go:"GO:0031371"(ubiquitin conjugating enzyme complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035370"(UBC13-UEV1A complex)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070534"(protein K63-linked ubiquitination)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|rcsb pdb:2A4D|rcsb pdb:2C2V|rcsb pdb:2HLW|rcsb pdb:6D6I|reactome:R-HSA-168638|reactome:R-HSA-168927|reactome:R-HSA-202424|reactome:R-HSA-2871837|reactome:R-HSA-445989|reactome:R-HSA-450302|reactome:R-HSA-450321|reactome:R-HSA-5607764|reactome:R-HSA-9020702|reactome:R-HSA-937039|reactome:R-HSA-937041|reactome:R-HSA-9646399|reactome:R-HSA-975110|reactome:R-HSA-975144|reactome:R-HSA-983168|dip:DIP-41911N	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S3|resulting-ptm:Q6PH85 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:3Gz33h06rkceJvO9VMHjBBtofZw9606	rogid:x95N7Dj2KIqu5gySX59xLmfthUg9606	intact-crc:5282F910401A0C40|rigid:eP6VyFPv6+pSnCIWHPUNe8BuYao	false	-	his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q6PH85	uniprotkb:P22314	intact:EBI-9917408|uniprotkb:Q5JSA6|uniprotkb:Q9NXR6|uniprotkb:Q5JSA5|uniprotkb:Q9NVJ1|uniprotkb:Q5JSA7|ensembl:ENSP00000417706	intact:EBI-709688|uniprotkb:Q96E13|uniprotkb:Q5JRR8|ensembl:ENSP00000338413|ensembl:ENSP00000366568	psi-mi:dcnl2_human(display_long)|uniprotkb:C13orf17(gene name synonym)|uniprotkb:DCUN1 domain-containing protein 2(gene name synonym)|uniprotkb:DCUN1L2(gene name synonym)|uniprotkb:Defective in cullin neddylation protein 1-like protein 2(gene name synonym)|uniprotkb:DCUN1D2(gene name)|psi-mi:DCUN1D2(display_short)	psi-mi:uba1_human(display_long)|uniprotkb:Ubiquitin-activating enzyme E1(gene name synonym)|uniprotkb:Protein A1S9(gene name synonym)|uniprotkb:UBA1(gene name)|psi-mi:UBA1(display_short)|uniprotkb:A1S9T(gene name synonym)|uniprotkb:UBE1(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9972011|imex:IM-22822-94	author-confidence:Z-score = 6.66	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001014305.1|dip:DIP-60768N|ensembl:ENSG00000150401(gene)|ensembl:ENST00000478244(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0031624"(ubiquitin conjugating enzyme binding)|go:"GO:0032182"(ubiquitin-like protein binding)|go:"GO:0045116"(protein neddylation)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0097602"(cullin family protein binding)|go:"GO:2000434"(regulation of protein neddylation)|go:"GO:2000436"(positive regulation of protein neddylation)|interpro:IPR005176(Protein of unknown function DUF298)|interpro:IPR009060(UBA-like)|interpro:IPR014764(Defective in cullin neddylation)|interpro:IPR042460|rcsb pdb:4GAO|reactome:R-HSA-8951664	refseq:NP_003325.2|refseq:NP_695012.1|refseq:XP_016885269.1|refseq:XP_016885270.1|dip:DIP-33686N|ensembl:ENSG00000130985(gene)|ensembl:ENST00000335972(transcript)|ensembl:ENST00000377351(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0004839"(ubiquitin activating enzyme activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0032446"(protein modification by small protein conjugation)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000011(Ubiquitin-activating enzyme, E1)|interpro:IPR000594(UBA/THIF-type NAD/FAD binding fold)|interpro:IPR018074|interpro:IPR018075|interpro:IPR018965|interpro:IPR019572|interpro:IPR032418|interpro:IPR032420|interpro:IPR033127|interpro:IPR035985|interpro:IPR038252|interpro:IPR042063|interpro:IPR042302|interpro:IPR042449|mint:P22314|rcsb pdb:4P22|rcsb pdb:6DC6|reactome:R-HSA-8866652|reactome:R-HSA-983168	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S3|resulting-ptm:Q6PH85 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:3Gz33h06rkceJvO9VMHjBBtofZw9606	rogid:q+vEeA0XLST0Zz173bmEt0dNbDE9606	intact-crc:5282F910401A0C40|rigid:eP6VyFPv6+pSnCIWHPUNe8BuYao	false	-	his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q6PH85	uniprotkb:P61088	intact:EBI-9917408|uniprotkb:Q5JSA6|uniprotkb:Q9NXR6|uniprotkb:Q5JSA5|uniprotkb:Q9NVJ1|uniprotkb:Q5JSA7|ensembl:ENSP00000417706	intact:EBI-1052908|uniprotkb:Q16781|uniprotkb:Q53Y81|ensembl:ENSP00000316176	psi-mi:dcnl2_human(display_long)|uniprotkb:C13orf17(gene name synonym)|uniprotkb:DCUN1 domain-containing protein 2(gene name synonym)|uniprotkb:DCUN1L2(gene name synonym)|uniprotkb:Defective in cullin neddylation protein 1-like protein 2(gene name synonym)|uniprotkb:DCUN1D2(gene name)|psi-mi:DCUN1D2(display_short)	psi-mi:ube2n_human(display_long)|uniprotkb:Ubiquitin-protein ligase N(gene name synonym)|uniprotkb:Ubiquitin carrier protein N(gene name synonym)|uniprotkb:Ubc13(gene name synonym)|uniprotkb:Bendless-like ubiquitin-conjugating enzyme(gene name synonym)|uniprotkb:UBE2N(gene name)|psi-mi:UBE2N(display_short)|uniprotkb:BLU(gene name synonym)|uniprotkb:UbcH13(gene name synonym)|uniprotkb:E2 ubiquitin-conjugating enzyme N(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9972011|imex:IM-22822-94	author-confidence:Z-score = 6.66	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001014305.1|dip:DIP-60768N|ensembl:ENSG00000150401(gene)|ensembl:ENST00000478244(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0031624"(ubiquitin conjugating enzyme binding)|go:"GO:0032182"(ubiquitin-like protein binding)|go:"GO:0045116"(protein neddylation)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0097602"(cullin family protein binding)|go:"GO:2000434"(regulation of protein neddylation)|go:"GO:2000436"(positive regulation of protein neddylation)|interpro:IPR005176(Protein of unknown function DUF298)|interpro:IPR009060(UBA-like)|interpro:IPR014764(Defective in cullin neddylation)|interpro:IPR042460|rcsb pdb:4GAO|reactome:R-HSA-8951664	refseq:NP_003339.1|dip:DIP-29829N|ensembl:ENSG00000177889(gene)|ensembl:ENST00000318066(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000729"(DNA double-strand break processing)|go:"GO:0001650"(fibrillar center)|go:"GO:0003723"(RNA binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006282"(regulation of DNA repair)|go:"GO:0006301"(postreplication repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016574"(histone ubiquitination)|go:"GO:0031058"(positive regulation of histone modification)|go:"GO:0031372"(UBC13-MMS2 complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033182"(regulation of histone ubiquitination)|go:"GO:0035370"(UBC13-UEV1A complex)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0061631"(ubiquitin conjugating enzyme activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070534"(protein K63-linked ubiquitination)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|interpro:IPR023313|rcsb pdb:1J7D|rcsb pdb:2C2V|rcsb pdb:3HCT|rcsb pdb:3HCU|rcsb pdb:3VON|rcsb pdb:3W31|rcsb pdb:4DHI|rcsb pdb:4DHJ|rcsb pdb:4DHZ|rcsb pdb:4IP3|rcsb pdb:4NR3|rcsb pdb:4NRG|rcsb pdb:4NRI|rcsb pdb:4ONL|rcsb pdb:4ONM|rcsb pdb:4ONN|rcsb pdb:4ORH|rcsb pdb:4TKP|rcsb pdb:4WHV|rcsb pdb:5AIT|rcsb pdb:5AIU|rcsb pdb:5EYA|rcsb pdb:5H7S|rcsb pdb:5VNZ|rcsb pdb:5VO0|rcsb pdb:5YWR|rcsb pdb:6D6I|rcsb pdb:6JKY|rcsb pdb:6KFP|rcsb pdb:6KG6|rcsb pdb:6KL4|rcsb pdb:6LP2|rcsb pdb:6P5B|rcsb pdb:6S53|reactome:R-HSA-168927|reactome:R-HSA-202424|reactome:R-HSA-2871837|reactome:R-HSA-445989|reactome:R-HSA-450302|reactome:R-HSA-450321|reactome:R-HSA-5607764|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-5696395|reactome:R-HSA-69473|reactome:R-HSA-8866654|reactome:R-HSA-9020702|reactome:R-HSA-937039|reactome:R-HSA-937041|reactome:R-HSA-9646399|reactome:R-HSA-975110|reactome:R-HSA-975144|reactome:R-HSA-983168|rcsb pdb:6ULH|rcsb pdb:6UMP|rcsb pdb:6UMS|rcsb pdb:7BBD|rcsb pdb:7BBF|rcsb pdb:7BXG|reactome:R-HSA-1169408|reactome:R-HSA-168638	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S3|resulting-ptm:Q6PH85 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:3Gz33h06rkceJvO9VMHjBBtofZw9606	rogid:dqdszHlq5FLPHC6UWX6uvkC6Yz89606	intact-crc:5282F910401A0C40|rigid:eP6VyFPv6+pSnCIWHPUNe8BuYao	false	-	his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q62925	uniprotkb:Q6ZWH5	intact:EBI-636664	intact:EBI-6873098|ensembl:ENSP00000395849|uniprotkb:Q96MB3|uniprotkb:A8MWG1|uniprotkb:Q45VJ4|uniprotkb:B9ZVR0|uniprotkb:Q6ZR11|uniprotkb:Q7Z671|uniprotkb:Q86XB1	psi-mi:m3k1_rat(display_long)|uniprotkb:MAPK/ERK kinase kinase 1(gene name synonym)|uniprotkb:Map3k1(gene name)|psi-mi:Map3k1(display_short)|uniprotkb:Mekk(gene name synonym)|uniprotkb:Mekk1(gene name synonym)	psi-mi:nek10_human(display_long)|uniprotkb:Never in mitosis A-related kinase 10(gene name synonym)|uniprotkb:NEK10(gene name)|psi-mi:NEK10(display_short)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9972061|imex:IM-22822-96	author-confidence:Z-score = 9.15	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:620966|refseq:NP_446339.1|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR007527(Zinc finger, SWIM-type)|go:"GO:0000165"(MAPK cascade)|interpro:IPR016024(Armadillo-type fold)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0002011"(morphogenesis of an epithelial sheet)|go:"GO:0003382"(epithelial cell morphogenesis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004706"(JUN kinase kinase kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007254"(JNK cascade)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008432"(JUN kinase binding)|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0016020"(membrane)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0031434"(mitogen-activated protein kinase kinase binding)|go:"GO:0031941"(filamentous actin)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0042060"(wound healing)|go:"GO:0043010"(camera-type eye development)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046625"(sphingolipid binding)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050434"(positive regulation of viral transcription)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0061029"(eyelid development in camera-type eye)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|reactome:R-RNO-166058|reactome:R-RNO-2871796|reactome:R-RNO-975138|reactome:R-RNO-975871|interpro:IPR011989(Armadillo-like helical)|mint:Q62925	refseq:NP_001026911.1|refseq:NP_001291313.1|refseq:NP_689747.3|refseq:XP_016861250.1|refseq:XP_016861251.1|refseq:XP_016861252.1|refseq:XP_016861253.1|refseq:XP_016861254.1|ensembl:ENSG00000163491(gene)|ensembl:ENST00000429845(transcript)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0031954"(positive regulation of protein autophosphorylation)|go:"GO:0070372"(regulation of ERK1 and ERK2 cascade)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0120197"(mucociliary clearance)|go:"GO:1902749"(regulation of cell cycle G2/M phase transition)|go:"GO:1902911"(protein kinase complex)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR042666|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0046872"(metal ion binding)|refseq:NP_955379.2	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S3|resulting-ptm:Q6ZWH5 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:EwhjYjowkZIAt4UyPcZBUtf9uak10116	rogid:1BqLrfd0JtHjkk7i1zwduMcFVQc9606	intact-crc:56278257513B60CE|rigid:ocuxdZm3OsUijs8SvGuyVHr3Ycc	false	sufficient binding region:433-481(IPR013083)	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q62925	uniprotkb:Q13404	intact:EBI-636664	intact:EBI-1050671|uniprotkb:Q13403|uniprotkb:Q13532|uniprotkb:Q96H34|uniprotkb:Q9GZT0|uniprotkb:Q9GZW1|uniprotkb:Q9H4J3|uniprotkb:Q9H4J4|uniprotkb:Q9UKL1|uniprotkb:Q9UM48|uniprotkb:Q9UM49|uniprotkb:Q9UM50|uniprotkb:Q5TGE3|uniprotkb:E1P629|uniprotkb:Q5TGE0|ensembl:ENSP00000360739	psi-mi:m3k1_rat(display_long)|uniprotkb:MAPK/ERK kinase kinase 1(gene name synonym)|uniprotkb:Map3k1(gene name)|psi-mi:Map3k1(display_short)|uniprotkb:Mekk(gene name synonym)|uniprotkb:Mekk1(gene name synonym)	psi-mi:ub2v1_human(display_long)|uniprotkb:CROC-1(gene name synonym)|uniprotkb:TRAF6-regulated IKK activator 1 beta Uev1A(gene name synonym)|uniprotkb:P/OKcl.19(orf name)|uniprotkb:UBE2V1(gene name)|psi-mi:UBE2V1(display_short)|uniprotkb:CROC1(gene name synonym)|uniprotkb:UBE2V(gene name synonym)|uniprotkb:UEV1(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9972061|imex:IM-22822-96	author-confidence:Z-score = 9.15	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:620966|refseq:NP_446339.1|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR007527(Zinc finger, SWIM-type)|go:"GO:0000165"(MAPK cascade)|interpro:IPR016024(Armadillo-type fold)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0002011"(morphogenesis of an epithelial sheet)|go:"GO:0003382"(epithelial cell morphogenesis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004706"(JUN kinase kinase kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007254"(JNK cascade)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008432"(JUN kinase binding)|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0016020"(membrane)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0031434"(mitogen-activated protein kinase kinase binding)|go:"GO:0031941"(filamentous actin)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0042060"(wound healing)|go:"GO:0043010"(camera-type eye development)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046625"(sphingolipid binding)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050434"(positive regulation of viral transcription)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0061029"(eyelid development in camera-type eye)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|reactome:R-RNO-166058|reactome:R-RNO-2871796|reactome:R-RNO-975138|reactome:R-RNO-975871|interpro:IPR011989(Armadillo-like helical)|mint:Q62925	refseq:NP_001027459.1|refseq:NP_068823.2|refseq:NP_071887.1|refseq:NP_954595.1|refseq:NP_954673.1|refseq:NP_001244322.1|refseq:NP_001244323.1|refseq:NP_001244325.1|ensembl:ENSG00000244687(gene)|ensembl:ENST00000371674(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006282"(regulation of DNA repair)|go:"GO:0006301"(postreplication repair)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0030154"(cell differentiation)|go:"GO:0031371"(ubiquitin conjugating enzyme complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035370"(UBC13-UEV1A complex)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070534"(protein K63-linked ubiquitination)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|rcsb pdb:2A4D|rcsb pdb:2C2V|rcsb pdb:2HLW|rcsb pdb:6D6I|reactome:R-HSA-168638|reactome:R-HSA-168927|reactome:R-HSA-202424|reactome:R-HSA-2871837|reactome:R-HSA-445989|reactome:R-HSA-450302|reactome:R-HSA-450321|reactome:R-HSA-5607764|reactome:R-HSA-9020702|reactome:R-HSA-937039|reactome:R-HSA-937041|reactome:R-HSA-9646399|reactome:R-HSA-975110|reactome:R-HSA-975144|reactome:R-HSA-983168|dip:DIP-41911N	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S3|resulting-ptm:Q6ZWH5 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:EwhjYjowkZIAt4UyPcZBUtf9uak10116	rogid:x95N7Dj2KIqu5gySX59xLmfthUg9606	intact-crc:56278257513B60CE|rigid:ocuxdZm3OsUijs8SvGuyVHr3Ycc	false	sufficient binding region:433-481(IPR013083)	his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q62925	uniprotkb:P22314	intact:EBI-636664	intact:EBI-709688|uniprotkb:Q96E13|uniprotkb:Q5JRR8|ensembl:ENSP00000338413|ensembl:ENSP00000366568	psi-mi:m3k1_rat(display_long)|uniprotkb:MAPK/ERK kinase kinase 1(gene name synonym)|uniprotkb:Map3k1(gene name)|psi-mi:Map3k1(display_short)|uniprotkb:Mekk(gene name synonym)|uniprotkb:Mekk1(gene name synonym)	psi-mi:uba1_human(display_long)|uniprotkb:Ubiquitin-activating enzyme E1(gene name synonym)|uniprotkb:Protein A1S9(gene name synonym)|uniprotkb:UBA1(gene name)|psi-mi:UBA1(display_short)|uniprotkb:A1S9T(gene name synonym)|uniprotkb:UBE1(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9972061|imex:IM-22822-96	author-confidence:Z-score = 9.15	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:620966|refseq:NP_446339.1|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR007527(Zinc finger, SWIM-type)|go:"GO:0000165"(MAPK cascade)|interpro:IPR016024(Armadillo-type fold)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0002011"(morphogenesis of an epithelial sheet)|go:"GO:0003382"(epithelial cell morphogenesis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004706"(JUN kinase kinase kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007254"(JNK cascade)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008432"(JUN kinase binding)|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0016020"(membrane)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0031434"(mitogen-activated protein kinase kinase binding)|go:"GO:0031941"(filamentous actin)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0042060"(wound healing)|go:"GO:0043010"(camera-type eye development)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046625"(sphingolipid binding)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050434"(positive regulation of viral transcription)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0061029"(eyelid development in camera-type eye)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|reactome:R-RNO-166058|reactome:R-RNO-2871796|reactome:R-RNO-975138|reactome:R-RNO-975871|interpro:IPR011989(Armadillo-like helical)|mint:Q62925	refseq:NP_003325.2|refseq:NP_695012.1|refseq:XP_016885269.1|refseq:XP_016885270.1|dip:DIP-33686N|ensembl:ENSG00000130985(gene)|ensembl:ENST00000335972(transcript)|ensembl:ENST00000377351(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0004839"(ubiquitin activating enzyme activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0032446"(protein modification by small protein conjugation)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000011(Ubiquitin-activating enzyme, E1)|interpro:IPR000594(UBA/THIF-type NAD/FAD binding fold)|interpro:IPR018074|interpro:IPR018075|interpro:IPR018965|interpro:IPR019572|interpro:IPR032418|interpro:IPR032420|interpro:IPR033127|interpro:IPR035985|interpro:IPR038252|interpro:IPR042063|interpro:IPR042302|interpro:IPR042449|mint:P22314|rcsb pdb:4P22|rcsb pdb:6DC6|reactome:R-HSA-8866652|reactome:R-HSA-983168	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S3|resulting-ptm:Q6ZWH5 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:EwhjYjowkZIAt4UyPcZBUtf9uak10116	rogid:q+vEeA0XLST0Zz173bmEt0dNbDE9606	intact-crc:56278257513B60CE|rigid:ocuxdZm3OsUijs8SvGuyVHr3Ycc	false	sufficient binding region:433-481(IPR013083)	his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q62925	uniprotkb:P61088	intact:EBI-636664	intact:EBI-1052908|uniprotkb:Q16781|uniprotkb:Q53Y81|ensembl:ENSP00000316176	psi-mi:m3k1_rat(display_long)|uniprotkb:MAPK/ERK kinase kinase 1(gene name synonym)|uniprotkb:Map3k1(gene name)|psi-mi:Map3k1(display_short)|uniprotkb:Mekk(gene name synonym)|uniprotkb:Mekk1(gene name synonym)	psi-mi:ube2n_human(display_long)|uniprotkb:Ubiquitin-protein ligase N(gene name synonym)|uniprotkb:Ubiquitin carrier protein N(gene name synonym)|uniprotkb:Ubc13(gene name synonym)|uniprotkb:Bendless-like ubiquitin-conjugating enzyme(gene name synonym)|uniprotkb:UBE2N(gene name)|psi-mi:UBE2N(display_short)|uniprotkb:BLU(gene name synonym)|uniprotkb:UbcH13(gene name synonym)|uniprotkb:E2 ubiquitin-conjugating enzyme N(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9972061|imex:IM-22822-96	author-confidence:Z-score = 9.15	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:620966|refseq:NP_446339.1|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR007527(Zinc finger, SWIM-type)|go:"GO:0000165"(MAPK cascade)|interpro:IPR016024(Armadillo-type fold)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0002011"(morphogenesis of an epithelial sheet)|go:"GO:0003382"(epithelial cell morphogenesis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004706"(JUN kinase kinase kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007254"(JNK cascade)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008432"(JUN kinase binding)|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0016020"(membrane)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0031434"(mitogen-activated protein kinase kinase binding)|go:"GO:0031941"(filamentous actin)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0042060"(wound healing)|go:"GO:0043010"(camera-type eye development)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046625"(sphingolipid binding)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050434"(positive regulation of viral transcription)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0061029"(eyelid development in camera-type eye)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|reactome:R-RNO-166058|reactome:R-RNO-2871796|reactome:R-RNO-975138|reactome:R-RNO-975871|interpro:IPR011989(Armadillo-like helical)|mint:Q62925	refseq:NP_003339.1|dip:DIP-29829N|ensembl:ENSG00000177889(gene)|ensembl:ENST00000318066(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000729"(DNA double-strand break processing)|go:"GO:0001650"(fibrillar center)|go:"GO:0003723"(RNA binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006282"(regulation of DNA repair)|go:"GO:0006301"(postreplication repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016574"(histone ubiquitination)|go:"GO:0031058"(positive regulation of histone modification)|go:"GO:0031372"(UBC13-MMS2 complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033182"(regulation of histone ubiquitination)|go:"GO:0035370"(UBC13-UEV1A complex)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0061631"(ubiquitin conjugating enzyme activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070534"(protein K63-linked ubiquitination)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|interpro:IPR023313|rcsb pdb:1J7D|rcsb pdb:2C2V|rcsb pdb:3HCT|rcsb pdb:3HCU|rcsb pdb:3VON|rcsb pdb:3W31|rcsb pdb:4DHI|rcsb pdb:4DHJ|rcsb pdb:4DHZ|rcsb pdb:4IP3|rcsb pdb:4NR3|rcsb pdb:4NRG|rcsb pdb:4NRI|rcsb pdb:4ONL|rcsb pdb:4ONM|rcsb pdb:4ONN|rcsb pdb:4ORH|rcsb pdb:4TKP|rcsb pdb:4WHV|rcsb pdb:5AIT|rcsb pdb:5AIU|rcsb pdb:5EYA|rcsb pdb:5H7S|rcsb pdb:5VNZ|rcsb pdb:5VO0|rcsb pdb:5YWR|rcsb pdb:6D6I|rcsb pdb:6JKY|rcsb pdb:6KFP|rcsb pdb:6KG6|rcsb pdb:6KL4|rcsb pdb:6LP2|rcsb pdb:6P5B|rcsb pdb:6S53|reactome:R-HSA-168927|reactome:R-HSA-202424|reactome:R-HSA-2871837|reactome:R-HSA-445989|reactome:R-HSA-450302|reactome:R-HSA-450321|reactome:R-HSA-5607764|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-5696395|reactome:R-HSA-69473|reactome:R-HSA-8866654|reactome:R-HSA-9020702|reactome:R-HSA-937039|reactome:R-HSA-937041|reactome:R-HSA-9646399|reactome:R-HSA-975110|reactome:R-HSA-975144|reactome:R-HSA-983168|rcsb pdb:6ULH|rcsb pdb:6UMP|rcsb pdb:6UMS|rcsb pdb:7BBD|rcsb pdb:7BBF|rcsb pdb:7BXG|reactome:R-HSA-1169408|reactome:R-HSA-168638	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S3|resulting-ptm:Q6ZWH5 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:EwhjYjowkZIAt4UyPcZBUtf9uak10116	rogid:dqdszHlq5FLPHC6UWX6uvkC6Yz89606	intact-crc:56278257513B60CE|rigid:ocuxdZm3OsUijs8SvGuyVHr3Ycc	false	sufficient binding region:433-481(IPR013083)	his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q62925	uniprotkb:Q6ZVM7	intact:EBI-636664	intact:EBI-3452240|uniprotkb:Q96M88|uniprotkb:Q86V61|uniprotkb:Q8TDE7|uniprotkb:B7Z7F4|ensembl:ENSP00000368818|uniprotkb:B7Z2L7	psi-mi:m3k1_rat(display_long)|uniprotkb:MAPK/ERK kinase kinase 1(gene name synonym)|uniprotkb:Map3k1(gene name)|psi-mi:Map3k1(display_short)|uniprotkb:Mekk(gene name synonym)|uniprotkb:Mekk1(gene name synonym)	psi-mi:tm1l2_human(display_long)|uniprotkb:TOM1L2(gene name)|psi-mi:TOM1L2(display_short)|uniprotkb:Target of Myb-like protein 2(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9972036|imex:IM-22822-95	author-confidence:Z-score = 10.77	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:620966|refseq:NP_446339.1|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR007527(Zinc finger, SWIM-type)|go:"GO:0000165"(MAPK cascade)|interpro:IPR016024(Armadillo-type fold)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0002011"(morphogenesis of an epithelial sheet)|go:"GO:0003382"(epithelial cell morphogenesis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004706"(JUN kinase kinase kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007254"(JNK cascade)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008432"(JUN kinase binding)|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0016020"(membrane)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0031434"(mitogen-activated protein kinase kinase binding)|go:"GO:0031941"(filamentous actin)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0042060"(wound healing)|go:"GO:0043010"(camera-type eye development)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046625"(sphingolipid binding)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050434"(positive regulation of viral transcription)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0061029"(eyelid development in camera-type eye)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|reactome:R-RNO-166058|reactome:R-RNO-2871796|reactome:R-RNO-975138|reactome:R-RNO-975871|interpro:IPR011989(Armadillo-like helical)|mint:Q62925	refseq:NP_001028723.1|refseq:NP_001076437.1|refseq:NP_001275715.1|refseq:NP_001275716.1|refseq:NP_001275717.1|refseq:NP_001275718.1|ensembl:ENSG00000175662(gene)|ensembl:ENST00000379504(transcript)|go:"GO:0005768"(endosome)|go:"GO:0007165"(signal transduction)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030276"(clathrin binding)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0045839"(negative regulation of mitotic nuclear division)|go:"GO:0070062"(extracellular exosome)|interpro:IPR002014(VHS)|interpro:IPR004152(GAT)|interpro:IPR008942(ENTH/VHS)|interpro:IPR014645(Target of Myb protein 1)|interpro:IPR027429|interpro:IPR038425|dip:DIP-61860N	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S3|resulting-ptm:Q6ZVM7 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:EwhjYjowkZIAt4UyPcZBUtf9uak10116	rogid:NZ3MLjhsMwb65v0h0qjwkpZjZJ09606	intact-crc:7A0EC440D50E32AB|rigid:GSOMHmcL6v94FptQlEC5tVsxXyo	false	sufficient binding region:433-481(IPR013083)	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q62925	uniprotkb:Q13404	intact:EBI-636664	intact:EBI-1050671|uniprotkb:Q13403|uniprotkb:Q13532|uniprotkb:Q96H34|uniprotkb:Q9GZT0|uniprotkb:Q9GZW1|uniprotkb:Q9H4J3|uniprotkb:Q9H4J4|uniprotkb:Q9UKL1|uniprotkb:Q9UM48|uniprotkb:Q9UM49|uniprotkb:Q9UM50|uniprotkb:Q5TGE3|uniprotkb:E1P629|uniprotkb:Q5TGE0|ensembl:ENSP00000360739	psi-mi:m3k1_rat(display_long)|uniprotkb:MAPK/ERK kinase kinase 1(gene name synonym)|uniprotkb:Map3k1(gene name)|psi-mi:Map3k1(display_short)|uniprotkb:Mekk(gene name synonym)|uniprotkb:Mekk1(gene name synonym)	psi-mi:ub2v1_human(display_long)|uniprotkb:CROC-1(gene name synonym)|uniprotkb:TRAF6-regulated IKK activator 1 beta Uev1A(gene name synonym)|uniprotkb:P/OKcl.19(orf name)|uniprotkb:UBE2V1(gene name)|psi-mi:UBE2V1(display_short)|uniprotkb:CROC1(gene name synonym)|uniprotkb:UBE2V(gene name synonym)|uniprotkb:UEV1(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9972036|imex:IM-22822-95	author-confidence:Z-score = 10.77	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:620966|refseq:NP_446339.1|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR007527(Zinc finger, SWIM-type)|go:"GO:0000165"(MAPK cascade)|interpro:IPR016024(Armadillo-type fold)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0002011"(morphogenesis of an epithelial sheet)|go:"GO:0003382"(epithelial cell morphogenesis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004706"(JUN kinase kinase kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007254"(JNK cascade)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008432"(JUN kinase binding)|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0016020"(membrane)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0031434"(mitogen-activated protein kinase kinase binding)|go:"GO:0031941"(filamentous actin)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0042060"(wound healing)|go:"GO:0043010"(camera-type eye development)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046625"(sphingolipid binding)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050434"(positive regulation of viral transcription)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0061029"(eyelid development in camera-type eye)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|reactome:R-RNO-166058|reactome:R-RNO-2871796|reactome:R-RNO-975138|reactome:R-RNO-975871|interpro:IPR011989(Armadillo-like helical)|mint:Q62925	refseq:NP_001027459.1|refseq:NP_068823.2|refseq:NP_071887.1|refseq:NP_954595.1|refseq:NP_954673.1|refseq:NP_001244322.1|refseq:NP_001244323.1|refseq:NP_001244325.1|ensembl:ENSG00000244687(gene)|ensembl:ENST00000371674(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006282"(regulation of DNA repair)|go:"GO:0006301"(postreplication repair)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0030154"(cell differentiation)|go:"GO:0031371"(ubiquitin conjugating enzyme complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035370"(UBC13-UEV1A complex)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070534"(protein K63-linked ubiquitination)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|rcsb pdb:2A4D|rcsb pdb:2C2V|rcsb pdb:2HLW|rcsb pdb:6D6I|reactome:R-HSA-168638|reactome:R-HSA-168927|reactome:R-HSA-202424|reactome:R-HSA-2871837|reactome:R-HSA-445989|reactome:R-HSA-450302|reactome:R-HSA-450321|reactome:R-HSA-5607764|reactome:R-HSA-9020702|reactome:R-HSA-937039|reactome:R-HSA-937041|reactome:R-HSA-9646399|reactome:R-HSA-975110|reactome:R-HSA-975144|reactome:R-HSA-983168|dip:DIP-41911N	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S3|resulting-ptm:Q6ZVM7 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:EwhjYjowkZIAt4UyPcZBUtf9uak10116	rogid:x95N7Dj2KIqu5gySX59xLmfthUg9606	intact-crc:7A0EC440D50E32AB|rigid:GSOMHmcL6v94FptQlEC5tVsxXyo	false	sufficient binding region:433-481(IPR013083)	his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q62925	uniprotkb:P22314	intact:EBI-636664	intact:EBI-709688|uniprotkb:Q96E13|uniprotkb:Q5JRR8|ensembl:ENSP00000338413|ensembl:ENSP00000366568	psi-mi:m3k1_rat(display_long)|uniprotkb:MAPK/ERK kinase kinase 1(gene name synonym)|uniprotkb:Map3k1(gene name)|psi-mi:Map3k1(display_short)|uniprotkb:Mekk(gene name synonym)|uniprotkb:Mekk1(gene name synonym)	psi-mi:uba1_human(display_long)|uniprotkb:Ubiquitin-activating enzyme E1(gene name synonym)|uniprotkb:Protein A1S9(gene name synonym)|uniprotkb:UBA1(gene name)|psi-mi:UBA1(display_short)|uniprotkb:A1S9T(gene name synonym)|uniprotkb:UBE1(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9972036|imex:IM-22822-95	author-confidence:Z-score = 10.77	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:620966|refseq:NP_446339.1|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR007527(Zinc finger, SWIM-type)|go:"GO:0000165"(MAPK cascade)|interpro:IPR016024(Armadillo-type fold)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0002011"(morphogenesis of an epithelial sheet)|go:"GO:0003382"(epithelial cell morphogenesis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004706"(JUN kinase kinase kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007254"(JNK cascade)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008432"(JUN kinase binding)|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0016020"(membrane)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0031434"(mitogen-activated protein kinase kinase binding)|go:"GO:0031941"(filamentous actin)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0042060"(wound healing)|go:"GO:0043010"(camera-type eye development)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046625"(sphingolipid binding)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050434"(positive regulation of viral transcription)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0061029"(eyelid development in camera-type eye)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|reactome:R-RNO-166058|reactome:R-RNO-2871796|reactome:R-RNO-975138|reactome:R-RNO-975871|interpro:IPR011989(Armadillo-like helical)|mint:Q62925	refseq:NP_003325.2|refseq:NP_695012.1|refseq:XP_016885269.1|refseq:XP_016885270.1|dip:DIP-33686N|ensembl:ENSG00000130985(gene)|ensembl:ENST00000335972(transcript)|ensembl:ENST00000377351(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0004839"(ubiquitin activating enzyme activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0032446"(protein modification by small protein conjugation)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000011(Ubiquitin-activating enzyme, E1)|interpro:IPR000594(UBA/THIF-type NAD/FAD binding fold)|interpro:IPR018074|interpro:IPR018075|interpro:IPR018965|interpro:IPR019572|interpro:IPR032418|interpro:IPR032420|interpro:IPR033127|interpro:IPR035985|interpro:IPR038252|interpro:IPR042063|interpro:IPR042302|interpro:IPR042449|mint:P22314|rcsb pdb:4P22|rcsb pdb:6DC6|reactome:R-HSA-8866652|reactome:R-HSA-983168	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S3|resulting-ptm:Q6ZVM7 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:EwhjYjowkZIAt4UyPcZBUtf9uak10116	rogid:q+vEeA0XLST0Zz173bmEt0dNbDE9606	intact-crc:7A0EC440D50E32AB|rigid:GSOMHmcL6v94FptQlEC5tVsxXyo	false	sufficient binding region:433-481(IPR013083)	his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q62925	uniprotkb:P61088	intact:EBI-636664	intact:EBI-1052908|uniprotkb:Q16781|uniprotkb:Q53Y81|ensembl:ENSP00000316176	psi-mi:m3k1_rat(display_long)|uniprotkb:MAPK/ERK kinase kinase 1(gene name synonym)|uniprotkb:Map3k1(gene name)|psi-mi:Map3k1(display_short)|uniprotkb:Mekk(gene name synonym)|uniprotkb:Mekk1(gene name synonym)	psi-mi:ube2n_human(display_long)|uniprotkb:Ubiquitin-protein ligase N(gene name synonym)|uniprotkb:Ubiquitin carrier protein N(gene name synonym)|uniprotkb:Ubc13(gene name synonym)|uniprotkb:Bendless-like ubiquitin-conjugating enzyme(gene name synonym)|uniprotkb:UBE2N(gene name)|psi-mi:UBE2N(display_short)|uniprotkb:BLU(gene name synonym)|uniprotkb:UbcH13(gene name synonym)|uniprotkb:E2 ubiquitin-conjugating enzyme N(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9972036|imex:IM-22822-95	author-confidence:Z-score = 10.77	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:620966|refseq:NP_446339.1|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR007527(Zinc finger, SWIM-type)|go:"GO:0000165"(MAPK cascade)|interpro:IPR016024(Armadillo-type fold)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0002011"(morphogenesis of an epithelial sheet)|go:"GO:0003382"(epithelial cell morphogenesis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004706"(JUN kinase kinase kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007254"(JNK cascade)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008432"(JUN kinase binding)|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0016020"(membrane)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0031434"(mitogen-activated protein kinase kinase binding)|go:"GO:0031941"(filamentous actin)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0042060"(wound healing)|go:"GO:0043010"(camera-type eye development)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046625"(sphingolipid binding)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050434"(positive regulation of viral transcription)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0061029"(eyelid development in camera-type eye)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|reactome:R-RNO-166058|reactome:R-RNO-2871796|reactome:R-RNO-975138|reactome:R-RNO-975871|interpro:IPR011989(Armadillo-like helical)|mint:Q62925	refseq:NP_003339.1|dip:DIP-29829N|ensembl:ENSG00000177889(gene)|ensembl:ENST00000318066(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000729"(DNA double-strand break processing)|go:"GO:0001650"(fibrillar center)|go:"GO:0003723"(RNA binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006282"(regulation of DNA repair)|go:"GO:0006301"(postreplication repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016574"(histone ubiquitination)|go:"GO:0031058"(positive regulation of histone modification)|go:"GO:0031372"(UBC13-MMS2 complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033182"(regulation of histone ubiquitination)|go:"GO:0035370"(UBC13-UEV1A complex)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0061631"(ubiquitin conjugating enzyme activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070534"(protein K63-linked ubiquitination)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|interpro:IPR023313|rcsb pdb:1J7D|rcsb pdb:2C2V|rcsb pdb:3HCT|rcsb pdb:3HCU|rcsb pdb:3VON|rcsb pdb:3W31|rcsb pdb:4DHI|rcsb pdb:4DHJ|rcsb pdb:4DHZ|rcsb pdb:4IP3|rcsb pdb:4NR3|rcsb pdb:4NRG|rcsb pdb:4NRI|rcsb pdb:4ONL|rcsb pdb:4ONM|rcsb pdb:4ONN|rcsb pdb:4ORH|rcsb pdb:4TKP|rcsb pdb:4WHV|rcsb pdb:5AIT|rcsb pdb:5AIU|rcsb pdb:5EYA|rcsb pdb:5H7S|rcsb pdb:5VNZ|rcsb pdb:5VO0|rcsb pdb:5YWR|rcsb pdb:6D6I|rcsb pdb:6JKY|rcsb pdb:6KFP|rcsb pdb:6KG6|rcsb pdb:6KL4|rcsb pdb:6LP2|rcsb pdb:6P5B|rcsb pdb:6S53|reactome:R-HSA-168927|reactome:R-HSA-202424|reactome:R-HSA-2871837|reactome:R-HSA-445989|reactome:R-HSA-450302|reactome:R-HSA-450321|reactome:R-HSA-5607764|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-5696395|reactome:R-HSA-69473|reactome:R-HSA-8866654|reactome:R-HSA-9020702|reactome:R-HSA-937039|reactome:R-HSA-937041|reactome:R-HSA-9646399|reactome:R-HSA-975110|reactome:R-HSA-975144|reactome:R-HSA-983168|rcsb pdb:6ULH|rcsb pdb:6UMP|rcsb pdb:6UMS|rcsb pdb:7BBD|rcsb pdb:7BBF|rcsb pdb:7BXG|reactome:R-HSA-1169408|reactome:R-HSA-168638	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S3|resulting-ptm:Q6ZVM7 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:EwhjYjowkZIAt4UyPcZBUtf9uak10116	rogid:dqdszHlq5FLPHC6UWX6uvkC6Yz89606	intact-crc:7A0EC440D50E32AB|rigid:GSOMHmcL6v94FptQlEC5tVsxXyo	false	sufficient binding region:433-481(IPR013083)	his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q62925	uniprotkb:Q8N0X7	intact:EBI-636664	intact:EBI-2643803|uniprotkb:Q9H1T3|uniprotkb:Q9H1T2|uniprotkb:O60349|uniprotkb:Q86Y67|ensembl:ENSP00000347314|ensembl:ENSP00000406061|ensembl:ENSP00000414147|ensembl:ENSP00000473599|ensembl:ENSP00000497209	psi-mi:m3k1_rat(display_long)|uniprotkb:MAPK/ERK kinase kinase 1(gene name synonym)|uniprotkb:Map3k1(gene name)|psi-mi:Map3k1(display_short)|uniprotkb:Mekk(gene name synonym)|uniprotkb:Mekk1(gene name synonym)	psi-mi:spart_human(display_long)|uniprotkb:SPART(gene name)|psi-mi:SPART(display_short)|uniprotkb:KIAA0610(gene name synonym)|uniprotkb:SPG20(gene name synonym)|uniprotkb:Spastic paraplegia 20 protein(gene name synonym)|uniprotkb:TAHCCP1(gene name synonym)|uniprotkb:Trans-activated by hepatitis C virus core protein 1(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9972086|imex:IM-22822-97	author-confidence:Z-score = 7.77	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:620966|refseq:NP_446339.1|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR007527(Zinc finger, SWIM-type)|go:"GO:0000165"(MAPK cascade)|interpro:IPR016024(Armadillo-type fold)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0002011"(morphogenesis of an epithelial sheet)|go:"GO:0003382"(epithelial cell morphogenesis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004706"(JUN kinase kinase kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007254"(JNK cascade)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008432"(JUN kinase binding)|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0016020"(membrane)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0031434"(mitogen-activated protein kinase kinase binding)|go:"GO:0031941"(filamentous actin)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0042060"(wound healing)|go:"GO:0043010"(camera-type eye development)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046625"(sphingolipid binding)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050434"(positive regulation of viral transcription)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0061029"(eyelid development in camera-type eye)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|reactome:R-RNO-166058|reactome:R-RNO-2871796|reactome:R-RNO-975138|reactome:R-RNO-975871|interpro:IPR011989(Armadillo-like helical)|mint:Q62925	refseq:NP_001135766.1|refseq:NP_001135767.1|refseq:NP_001135768.1|refseq:NP_055902.1|refseq:XP_011533314.1|refseq:XP_005266370.1|refseq:XP_005266371.1|refseq:XP_005266372.1|ensembl:ENSG00000133104(gene)|ensembl:ENST00000355182(transcript)|ensembl:ENST00000438666(transcript)|ensembl:ENST00000451493(transcript)|ensembl:ENST00000494062(transcript)|ensembl:ENST00000650221(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0009838"(abscission)|go:"GO:0030496"(midbody)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0034389"(lipid droplet organization)|go:"GO:0045202"(synapse)|go:"GO:0048698"(negative regulation of collateral sprouting in absence of injury)|go:"GO:0050905"(neuromuscular process)|go:"GO:0051301"(cell division)|go:"GO:0051881"(regulation of mitochondrial membrane potential)|go:"GO:0060612"(adipose tissue development)|interpro:IPR007330(MIT)|interpro:IPR009686(Senescence-associated)|interpro:IPR036181|rcsb pdb:2DL1|rcsb pdb:4U7I|go:"GO:0030514"(negative regulation of BMP signaling pathway)|refseq:XP_005266374.1	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S3|resulting-ptm:Q8N0X7 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:EwhjYjowkZIAt4UyPcZBUtf9uak10116	rogid:Km2bYRg7JLYy7voEgYVdAHZhzE09606	intact-crc:BBDC908D1E5A44F2|rigid:jZw8cnVSxs+OonBu+gjx2wlHZXs	false	sufficient binding region:433-481(IPR013083)	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q62925	uniprotkb:Q13404	intact:EBI-636664	intact:EBI-1050671|uniprotkb:Q13403|uniprotkb:Q13532|uniprotkb:Q96H34|uniprotkb:Q9GZT0|uniprotkb:Q9GZW1|uniprotkb:Q9H4J3|uniprotkb:Q9H4J4|uniprotkb:Q9UKL1|uniprotkb:Q9UM48|uniprotkb:Q9UM49|uniprotkb:Q9UM50|uniprotkb:Q5TGE3|uniprotkb:E1P629|uniprotkb:Q5TGE0|ensembl:ENSP00000360739	psi-mi:m3k1_rat(display_long)|uniprotkb:MAPK/ERK kinase kinase 1(gene name synonym)|uniprotkb:Map3k1(gene name)|psi-mi:Map3k1(display_short)|uniprotkb:Mekk(gene name synonym)|uniprotkb:Mekk1(gene name synonym)	psi-mi:ub2v1_human(display_long)|uniprotkb:CROC-1(gene name synonym)|uniprotkb:TRAF6-regulated IKK activator 1 beta Uev1A(gene name synonym)|uniprotkb:P/OKcl.19(orf name)|uniprotkb:UBE2V1(gene name)|psi-mi:UBE2V1(display_short)|uniprotkb:CROC1(gene name synonym)|uniprotkb:UBE2V(gene name synonym)|uniprotkb:UEV1(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9972086|imex:IM-22822-97	author-confidence:Z-score = 7.77	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:620966|refseq:NP_446339.1|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR007527(Zinc finger, SWIM-type)|go:"GO:0000165"(MAPK cascade)|interpro:IPR016024(Armadillo-type fold)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0002011"(morphogenesis of an epithelial sheet)|go:"GO:0003382"(epithelial cell morphogenesis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004706"(JUN kinase kinase kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007254"(JNK cascade)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008432"(JUN kinase binding)|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0016020"(membrane)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0031434"(mitogen-activated protein kinase kinase binding)|go:"GO:0031941"(filamentous actin)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0042060"(wound healing)|go:"GO:0043010"(camera-type eye development)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046625"(sphingolipid binding)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050434"(positive regulation of viral transcription)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0061029"(eyelid development in camera-type eye)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|reactome:R-RNO-166058|reactome:R-RNO-2871796|reactome:R-RNO-975138|reactome:R-RNO-975871|interpro:IPR011989(Armadillo-like helical)|mint:Q62925	refseq:NP_001027459.1|refseq:NP_068823.2|refseq:NP_071887.1|refseq:NP_954595.1|refseq:NP_954673.1|refseq:NP_001244322.1|refseq:NP_001244323.1|refseq:NP_001244325.1|ensembl:ENSG00000244687(gene)|ensembl:ENST00000371674(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006282"(regulation of DNA repair)|go:"GO:0006301"(postreplication repair)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0030154"(cell differentiation)|go:"GO:0031371"(ubiquitin conjugating enzyme complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035370"(UBC13-UEV1A complex)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070534"(protein K63-linked ubiquitination)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|rcsb pdb:2A4D|rcsb pdb:2C2V|rcsb pdb:2HLW|rcsb pdb:6D6I|reactome:R-HSA-168638|reactome:R-HSA-168927|reactome:R-HSA-202424|reactome:R-HSA-2871837|reactome:R-HSA-445989|reactome:R-HSA-450302|reactome:R-HSA-450321|reactome:R-HSA-5607764|reactome:R-HSA-9020702|reactome:R-HSA-937039|reactome:R-HSA-937041|reactome:R-HSA-9646399|reactome:R-HSA-975110|reactome:R-HSA-975144|reactome:R-HSA-983168|dip:DIP-41911N	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S3|resulting-ptm:Q8N0X7 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:EwhjYjowkZIAt4UyPcZBUtf9uak10116	rogid:x95N7Dj2KIqu5gySX59xLmfthUg9606	intact-crc:BBDC908D1E5A44F2|rigid:jZw8cnVSxs+OonBu+gjx2wlHZXs	false	sufficient binding region:433-481(IPR013083)	his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q62925	uniprotkb:P22314	intact:EBI-636664	intact:EBI-709688|uniprotkb:Q96E13|uniprotkb:Q5JRR8|ensembl:ENSP00000338413|ensembl:ENSP00000366568	psi-mi:m3k1_rat(display_long)|uniprotkb:MAPK/ERK kinase kinase 1(gene name synonym)|uniprotkb:Map3k1(gene name)|psi-mi:Map3k1(display_short)|uniprotkb:Mekk(gene name synonym)|uniprotkb:Mekk1(gene name synonym)	psi-mi:uba1_human(display_long)|uniprotkb:Ubiquitin-activating enzyme E1(gene name synonym)|uniprotkb:Protein A1S9(gene name synonym)|uniprotkb:UBA1(gene name)|psi-mi:UBA1(display_short)|uniprotkb:A1S9T(gene name synonym)|uniprotkb:UBE1(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9972086|imex:IM-22822-97	author-confidence:Z-score = 7.77	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:620966|refseq:NP_446339.1|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR007527(Zinc finger, SWIM-type)|go:"GO:0000165"(MAPK cascade)|interpro:IPR016024(Armadillo-type fold)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0002011"(morphogenesis of an epithelial sheet)|go:"GO:0003382"(epithelial cell morphogenesis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004706"(JUN kinase kinase kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007254"(JNK cascade)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008432"(JUN kinase binding)|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0016020"(membrane)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0031434"(mitogen-activated protein kinase kinase binding)|go:"GO:0031941"(filamentous actin)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0042060"(wound healing)|go:"GO:0043010"(camera-type eye development)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046625"(sphingolipid binding)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050434"(positive regulation of viral transcription)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0061029"(eyelid development in camera-type eye)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|reactome:R-RNO-166058|reactome:R-RNO-2871796|reactome:R-RNO-975138|reactome:R-RNO-975871|interpro:IPR011989(Armadillo-like helical)|mint:Q62925	refseq:NP_003325.2|refseq:NP_695012.1|refseq:XP_016885269.1|refseq:XP_016885270.1|dip:DIP-33686N|ensembl:ENSG00000130985(gene)|ensembl:ENST00000335972(transcript)|ensembl:ENST00000377351(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0004839"(ubiquitin activating enzyme activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0032446"(protein modification by small protein conjugation)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000011(Ubiquitin-activating enzyme, E1)|interpro:IPR000594(UBA/THIF-type NAD/FAD binding fold)|interpro:IPR018074|interpro:IPR018075|interpro:IPR018965|interpro:IPR019572|interpro:IPR032418|interpro:IPR032420|interpro:IPR033127|interpro:IPR035985|interpro:IPR038252|interpro:IPR042063|interpro:IPR042302|interpro:IPR042449|mint:P22314|rcsb pdb:4P22|rcsb pdb:6DC6|reactome:R-HSA-8866652|reactome:R-HSA-983168	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S3|resulting-ptm:Q8N0X7 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:EwhjYjowkZIAt4UyPcZBUtf9uak10116	rogid:q+vEeA0XLST0Zz173bmEt0dNbDE9606	intact-crc:BBDC908D1E5A44F2|rigid:jZw8cnVSxs+OonBu+gjx2wlHZXs	false	sufficient binding region:433-481(IPR013083)	his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q62925	uniprotkb:P61088	intact:EBI-636664	intact:EBI-1052908|uniprotkb:Q16781|uniprotkb:Q53Y81|ensembl:ENSP00000316176	psi-mi:m3k1_rat(display_long)|uniprotkb:MAPK/ERK kinase kinase 1(gene name synonym)|uniprotkb:Map3k1(gene name)|psi-mi:Map3k1(display_short)|uniprotkb:Mekk(gene name synonym)|uniprotkb:Mekk1(gene name synonym)	psi-mi:ube2n_human(display_long)|uniprotkb:Ubiquitin-protein ligase N(gene name synonym)|uniprotkb:Ubiquitin carrier protein N(gene name synonym)|uniprotkb:Ubc13(gene name synonym)|uniprotkb:Bendless-like ubiquitin-conjugating enzyme(gene name synonym)|uniprotkb:UBE2N(gene name)|psi-mi:UBE2N(display_short)|uniprotkb:BLU(gene name synonym)|uniprotkb:UbcH13(gene name synonym)|uniprotkb:E2 ubiquitin-conjugating enzyme N(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9972086|imex:IM-22822-97	author-confidence:Z-score = 7.77	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:620966|refseq:NP_446339.1|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR007527(Zinc finger, SWIM-type)|go:"GO:0000165"(MAPK cascade)|interpro:IPR016024(Armadillo-type fold)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0002011"(morphogenesis of an epithelial sheet)|go:"GO:0003382"(epithelial cell morphogenesis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004706"(JUN kinase kinase kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007254"(JNK cascade)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008432"(JUN kinase binding)|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0016020"(membrane)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0031434"(mitogen-activated protein kinase kinase binding)|go:"GO:0031941"(filamentous actin)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0042060"(wound healing)|go:"GO:0043010"(camera-type eye development)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046625"(sphingolipid binding)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050434"(positive regulation of viral transcription)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0061029"(eyelid development in camera-type eye)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|reactome:R-RNO-166058|reactome:R-RNO-2871796|reactome:R-RNO-975138|reactome:R-RNO-975871|interpro:IPR011989(Armadillo-like helical)|mint:Q62925	refseq:NP_003339.1|dip:DIP-29829N|ensembl:ENSG00000177889(gene)|ensembl:ENST00000318066(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000729"(DNA double-strand break processing)|go:"GO:0001650"(fibrillar center)|go:"GO:0003723"(RNA binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006282"(regulation of DNA repair)|go:"GO:0006301"(postreplication repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016574"(histone ubiquitination)|go:"GO:0031058"(positive regulation of histone modification)|go:"GO:0031372"(UBC13-MMS2 complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033182"(regulation of histone ubiquitination)|go:"GO:0035370"(UBC13-UEV1A complex)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0061631"(ubiquitin conjugating enzyme activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070534"(protein K63-linked ubiquitination)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|interpro:IPR023313|rcsb pdb:1J7D|rcsb pdb:2C2V|rcsb pdb:3HCT|rcsb pdb:3HCU|rcsb pdb:3VON|rcsb pdb:3W31|rcsb pdb:4DHI|rcsb pdb:4DHJ|rcsb pdb:4DHZ|rcsb pdb:4IP3|rcsb pdb:4NR3|rcsb pdb:4NRG|rcsb pdb:4NRI|rcsb pdb:4ONL|rcsb pdb:4ONM|rcsb pdb:4ONN|rcsb pdb:4ORH|rcsb pdb:4TKP|rcsb pdb:4WHV|rcsb pdb:5AIT|rcsb pdb:5AIU|rcsb pdb:5EYA|rcsb pdb:5H7S|rcsb pdb:5VNZ|rcsb pdb:5VO0|rcsb pdb:5YWR|rcsb pdb:6D6I|rcsb pdb:6JKY|rcsb pdb:6KFP|rcsb pdb:6KG6|rcsb pdb:6KL4|rcsb pdb:6LP2|rcsb pdb:6P5B|rcsb pdb:6S53|reactome:R-HSA-168927|reactome:R-HSA-202424|reactome:R-HSA-2871837|reactome:R-HSA-445989|reactome:R-HSA-450302|reactome:R-HSA-450321|reactome:R-HSA-5607764|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-5696395|reactome:R-HSA-69473|reactome:R-HSA-8866654|reactome:R-HSA-9020702|reactome:R-HSA-937039|reactome:R-HSA-937041|reactome:R-HSA-9646399|reactome:R-HSA-975110|reactome:R-HSA-975144|reactome:R-HSA-983168|rcsb pdb:6ULH|rcsb pdb:6UMP|rcsb pdb:6UMS|rcsb pdb:7BBD|rcsb pdb:7BBF|rcsb pdb:7BXG|reactome:R-HSA-1169408|reactome:R-HSA-168638	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S3|resulting-ptm:Q8N0X7 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:EwhjYjowkZIAt4UyPcZBUtf9uak10116	rogid:dqdszHlq5FLPHC6UWX6uvkC6Yz89606	intact-crc:BBDC908D1E5A44F2|rigid:jZw8cnVSxs+OonBu+gjx2wlHZXs	false	sufficient binding region:433-481(IPR013083)	his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q8NB25	uniprotkb:Q62925	intact:EBI-9917523|uniprotkb:B9DI75|uniprotkb:Q5TBS9|uniprotkb:Q96GY8|uniprotkb:Q9H851|uniprotkb:Q7Z323|uniprotkb:Q9H0J8|uniprotkb:F8W8D6|ensembl:ENSP00000342604	intact:EBI-636664	psi-mi:f184a_human(display_long)|uniprotkb:C6orf60(gene name synonym)|uniprotkb:FAM184A(gene name)|psi-mi:FAM184A(display_short)	psi-mi:m3k1_rat(display_long)|uniprotkb:MAPK/ERK kinase kinase 1(gene name synonym)|uniprotkb:Map3k1(gene name)|psi-mi:Map3k1(display_short)|uniprotkb:Mekk(gene name synonym)|uniprotkb:Mekk1(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9972137|imex:IM-22822-99	author-confidence:Z-score = 4.37	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001093881.1|refseq:NP_001275505.1|refseq:NP_078857.5|ensembl:ENSG00000111879(gene)|ensembl:ENST00000338891(transcript)|go:"GO:0005615"(extracellular space)|interpro:IPR029605|interpro:IPR029607|interpro:IPR039478	rgd:620966|refseq:NP_446339.1|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR007527(Zinc finger, SWIM-type)|go:"GO:0000165"(MAPK cascade)|interpro:IPR016024(Armadillo-type fold)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0002011"(morphogenesis of an epithelial sheet)|go:"GO:0003382"(epithelial cell morphogenesis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004706"(JUN kinase kinase kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007254"(JNK cascade)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008432"(JUN kinase binding)|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0016020"(membrane)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0031434"(mitogen-activated protein kinase kinase binding)|go:"GO:0031941"(filamentous actin)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0042060"(wound healing)|go:"GO:0043010"(camera-type eye development)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046625"(sphingolipid binding)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050434"(positive regulation of viral transcription)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0061029"(eyelid development in camera-type eye)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|reactome:R-RNO-166058|reactome:R-RNO-2871796|reactome:R-RNO-975138|reactome:R-RNO-975871|interpro:IPR011989(Armadillo-like helical)|mint:Q62925	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S3|resulting-ptm:Q8NB25 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:A9gX4FWK+lMGWE31zzMr1cszuHg9606	rogid:EwhjYjowkZIAt4UyPcZBUtf9uak10116	intact-crc:C26EBBD79AC044B8|rigid:sF7Okor0kUzv2Ll+7+VMlYDWwJA	false	-	sufficient binding region:433-481(IPR013083)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q8NB25	uniprotkb:Q13404	intact:EBI-9917523|uniprotkb:B9DI75|uniprotkb:Q5TBS9|uniprotkb:Q96GY8|uniprotkb:Q9H851|uniprotkb:Q7Z323|uniprotkb:Q9H0J8|uniprotkb:F8W8D6|ensembl:ENSP00000342604	intact:EBI-1050671|uniprotkb:Q13403|uniprotkb:Q13532|uniprotkb:Q96H34|uniprotkb:Q9GZT0|uniprotkb:Q9GZW1|uniprotkb:Q9H4J3|uniprotkb:Q9H4J4|uniprotkb:Q9UKL1|uniprotkb:Q9UM48|uniprotkb:Q9UM49|uniprotkb:Q9UM50|uniprotkb:Q5TGE3|uniprotkb:E1P629|uniprotkb:Q5TGE0|ensembl:ENSP00000360739	psi-mi:f184a_human(display_long)|uniprotkb:C6orf60(gene name synonym)|uniprotkb:FAM184A(gene name)|psi-mi:FAM184A(display_short)	psi-mi:ub2v1_human(display_long)|uniprotkb:CROC-1(gene name synonym)|uniprotkb:TRAF6-regulated IKK activator 1 beta Uev1A(gene name synonym)|uniprotkb:P/OKcl.19(orf name)|uniprotkb:UBE2V1(gene name)|psi-mi:UBE2V1(display_short)|uniprotkb:CROC1(gene name synonym)|uniprotkb:UBE2V(gene name synonym)|uniprotkb:UEV1(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9972137|imex:IM-22822-99	author-confidence:Z-score = 4.37	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001093881.1|refseq:NP_001275505.1|refseq:NP_078857.5|ensembl:ENSG00000111879(gene)|ensembl:ENST00000338891(transcript)|go:"GO:0005615"(extracellular space)|interpro:IPR029605|interpro:IPR029607|interpro:IPR039478	refseq:NP_001027459.1|refseq:NP_068823.2|refseq:NP_071887.1|refseq:NP_954595.1|refseq:NP_954673.1|refseq:NP_001244322.1|refseq:NP_001244323.1|refseq:NP_001244325.1|ensembl:ENSG00000244687(gene)|ensembl:ENST00000371674(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006282"(regulation of DNA repair)|go:"GO:0006301"(postreplication repair)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0030154"(cell differentiation)|go:"GO:0031371"(ubiquitin conjugating enzyme complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035370"(UBC13-UEV1A complex)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070534"(protein K63-linked ubiquitination)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|rcsb pdb:2A4D|rcsb pdb:2C2V|rcsb pdb:2HLW|rcsb pdb:6D6I|reactome:R-HSA-168638|reactome:R-HSA-168927|reactome:R-HSA-202424|reactome:R-HSA-2871837|reactome:R-HSA-445989|reactome:R-HSA-450302|reactome:R-HSA-450321|reactome:R-HSA-5607764|reactome:R-HSA-9020702|reactome:R-HSA-937039|reactome:R-HSA-937041|reactome:R-HSA-9646399|reactome:R-HSA-975110|reactome:R-HSA-975144|reactome:R-HSA-983168|dip:DIP-41911N	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S3|resulting-ptm:Q8NB25 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:A9gX4FWK+lMGWE31zzMr1cszuHg9606	rogid:x95N7Dj2KIqu5gySX59xLmfthUg9606	intact-crc:C26EBBD79AC044B8|rigid:sF7Okor0kUzv2Ll+7+VMlYDWwJA	false	-	his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q8NB25	uniprotkb:P22314	intact:EBI-9917523|uniprotkb:B9DI75|uniprotkb:Q5TBS9|uniprotkb:Q96GY8|uniprotkb:Q9H851|uniprotkb:Q7Z323|uniprotkb:Q9H0J8|uniprotkb:F8W8D6|ensembl:ENSP00000342604	intact:EBI-709688|uniprotkb:Q96E13|uniprotkb:Q5JRR8|ensembl:ENSP00000338413|ensembl:ENSP00000366568	psi-mi:f184a_human(display_long)|uniprotkb:C6orf60(gene name synonym)|uniprotkb:FAM184A(gene name)|psi-mi:FAM184A(display_short)	psi-mi:uba1_human(display_long)|uniprotkb:Ubiquitin-activating enzyme E1(gene name synonym)|uniprotkb:Protein A1S9(gene name synonym)|uniprotkb:UBA1(gene name)|psi-mi:UBA1(display_short)|uniprotkb:A1S9T(gene name synonym)|uniprotkb:UBE1(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9972137|imex:IM-22822-99	author-confidence:Z-score = 4.37	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001093881.1|refseq:NP_001275505.1|refseq:NP_078857.5|ensembl:ENSG00000111879(gene)|ensembl:ENST00000338891(transcript)|go:"GO:0005615"(extracellular space)|interpro:IPR029605|interpro:IPR029607|interpro:IPR039478	refseq:NP_003325.2|refseq:NP_695012.1|refseq:XP_016885269.1|refseq:XP_016885270.1|dip:DIP-33686N|ensembl:ENSG00000130985(gene)|ensembl:ENST00000335972(transcript)|ensembl:ENST00000377351(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0004839"(ubiquitin activating enzyme activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0032446"(protein modification by small protein conjugation)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000011(Ubiquitin-activating enzyme, E1)|interpro:IPR000594(UBA/THIF-type NAD/FAD binding fold)|interpro:IPR018074|interpro:IPR018075|interpro:IPR018965|interpro:IPR019572|interpro:IPR032418|interpro:IPR032420|interpro:IPR033127|interpro:IPR035985|interpro:IPR038252|interpro:IPR042063|interpro:IPR042302|interpro:IPR042449|mint:P22314|rcsb pdb:4P22|rcsb pdb:6DC6|reactome:R-HSA-8866652|reactome:R-HSA-983168	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S3|resulting-ptm:Q8NB25 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:A9gX4FWK+lMGWE31zzMr1cszuHg9606	rogid:q+vEeA0XLST0Zz173bmEt0dNbDE9606	intact-crc:C26EBBD79AC044B8|rigid:sF7Okor0kUzv2Ll+7+VMlYDWwJA	false	-	his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q8NB25	uniprotkb:P61088	intact:EBI-9917523|uniprotkb:B9DI75|uniprotkb:Q5TBS9|uniprotkb:Q96GY8|uniprotkb:Q9H851|uniprotkb:Q7Z323|uniprotkb:Q9H0J8|uniprotkb:F8W8D6|ensembl:ENSP00000342604	intact:EBI-1052908|uniprotkb:Q16781|uniprotkb:Q53Y81|ensembl:ENSP00000316176	psi-mi:f184a_human(display_long)|uniprotkb:C6orf60(gene name synonym)|uniprotkb:FAM184A(gene name)|psi-mi:FAM184A(display_short)	psi-mi:ube2n_human(display_long)|uniprotkb:Ubiquitin-protein ligase N(gene name synonym)|uniprotkb:Ubiquitin carrier protein N(gene name synonym)|uniprotkb:Ubc13(gene name synonym)|uniprotkb:Bendless-like ubiquitin-conjugating enzyme(gene name synonym)|uniprotkb:UBE2N(gene name)|psi-mi:UBE2N(display_short)|uniprotkb:BLU(gene name synonym)|uniprotkb:UbcH13(gene name synonym)|uniprotkb:E2 ubiquitin-conjugating enzyme N(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9972137|imex:IM-22822-99	author-confidence:Z-score = 4.37	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001093881.1|refseq:NP_001275505.1|refseq:NP_078857.5|ensembl:ENSG00000111879(gene)|ensembl:ENST00000338891(transcript)|go:"GO:0005615"(extracellular space)|interpro:IPR029605|interpro:IPR029607|interpro:IPR039478	refseq:NP_003339.1|dip:DIP-29829N|ensembl:ENSG00000177889(gene)|ensembl:ENST00000318066(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000729"(DNA double-strand break processing)|go:"GO:0001650"(fibrillar center)|go:"GO:0003723"(RNA binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006282"(regulation of DNA repair)|go:"GO:0006301"(postreplication repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016574"(histone ubiquitination)|go:"GO:0031058"(positive regulation of histone modification)|go:"GO:0031372"(UBC13-MMS2 complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033182"(regulation of histone ubiquitination)|go:"GO:0035370"(UBC13-UEV1A complex)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0061631"(ubiquitin conjugating enzyme activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070534"(protein K63-linked ubiquitination)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|interpro:IPR023313|rcsb pdb:1J7D|rcsb pdb:2C2V|rcsb pdb:3HCT|rcsb pdb:3HCU|rcsb pdb:3VON|rcsb pdb:3W31|rcsb pdb:4DHI|rcsb pdb:4DHJ|rcsb pdb:4DHZ|rcsb pdb:4IP3|rcsb pdb:4NR3|rcsb pdb:4NRG|rcsb pdb:4NRI|rcsb pdb:4ONL|rcsb pdb:4ONM|rcsb pdb:4ONN|rcsb pdb:4ORH|rcsb pdb:4TKP|rcsb pdb:4WHV|rcsb pdb:5AIT|rcsb pdb:5AIU|rcsb pdb:5EYA|rcsb pdb:5H7S|rcsb pdb:5VNZ|rcsb pdb:5VO0|rcsb pdb:5YWR|rcsb pdb:6D6I|rcsb pdb:6JKY|rcsb pdb:6KFP|rcsb pdb:6KG6|rcsb pdb:6KL4|rcsb pdb:6LP2|rcsb pdb:6P5B|rcsb pdb:6S53|reactome:R-HSA-168927|reactome:R-HSA-202424|reactome:R-HSA-2871837|reactome:R-HSA-445989|reactome:R-HSA-450302|reactome:R-HSA-450321|reactome:R-HSA-5607764|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-5696395|reactome:R-HSA-69473|reactome:R-HSA-8866654|reactome:R-HSA-9020702|reactome:R-HSA-937039|reactome:R-HSA-937041|reactome:R-HSA-9646399|reactome:R-HSA-975110|reactome:R-HSA-975144|reactome:R-HSA-983168|rcsb pdb:6ULH|rcsb pdb:6UMP|rcsb pdb:6UMS|rcsb pdb:7BBD|rcsb pdb:7BBF|rcsb pdb:7BXG|reactome:R-HSA-1169408|reactome:R-HSA-168638	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S3|resulting-ptm:Q8NB25 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:A9gX4FWK+lMGWE31zzMr1cszuHg9606	rogid:dqdszHlq5FLPHC6UWX6uvkC6Yz89606	intact-crc:C26EBBD79AC044B8|rigid:sF7Okor0kUzv2Ll+7+VMlYDWwJA	false	-	his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q62925	uniprotkb:Q8N5Y2	intact:EBI-636664	intact:EBI-2560796|ensembl:ENSP00000312244|uniprotkb:Q9Y5Z8|uniprotkb:Q9UG70|uniprotkb:B7Z227|uniprotkb:B4DUV8|uniprotkb:A6NCU2|uniprotkb:A6NHW8|uniprotkb:A8K165	psi-mi:m3k1_rat(display_long)|uniprotkb:MAPK/ERK kinase kinase 1(gene name synonym)|uniprotkb:Map3k1(gene name)|psi-mi:Map3k1(display_short)|uniprotkb:Mekk(gene name synonym)|uniprotkb:Mekk1(gene name synonym)	psi-mi:ms3l1_human(display_long)|uniprotkb:MSL3(gene name)|psi-mi:MSL3(display_short)|uniprotkb:MSL3L1(gene name synonym)|uniprotkb:Male-specific lethal-3 protein-like 1(gene name synonym)|uniprotkb:Male-specific lethal-3 homolog 1(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9972111|imex:IM-22822-98	author-confidence:Z-score = 5.14|author-confidence:Z-score = 10.77	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:620966|refseq:NP_446339.1|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR007527(Zinc finger, SWIM-type)|go:"GO:0000165"(MAPK cascade)|interpro:IPR016024(Armadillo-type fold)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0002011"(morphogenesis of an epithelial sheet)|go:"GO:0003382"(epithelial cell morphogenesis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004706"(JUN kinase kinase kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007254"(JNK cascade)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008432"(JUN kinase binding)|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0016020"(membrane)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0031434"(mitogen-activated protein kinase kinase binding)|go:"GO:0031941"(filamentous actin)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0042060"(wound healing)|go:"GO:0043010"(camera-type eye development)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046625"(sphingolipid binding)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050434"(positive regulation of viral transcription)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0061029"(eyelid development in camera-type eye)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|reactome:R-RNO-166058|reactome:R-RNO-2871796|reactome:R-RNO-975138|reactome:R-RNO-975871|interpro:IPR011989(Armadillo-like helical)|mint:Q62925	ensembl:ENSG00000005302(gene)|ensembl:ENST00000312196(transcript)|go:"GO:0000123"(histone acetyltransferase complex)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006342"|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0016573"(histone acetylation)|go:"GO:0016575"(histone deacetylation)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035267"(NuA4 histone acetyltransferase complex)|go:"GO:0043967"(histone H4 acetylation)|go:"GO:0043968"(histone H2A acetylation)|go:"GO:0043984"(histone H4-K16 acetylation)|go:"GO:0046972"("histone acetyltransferase activity (H4-K16 specific)")|go:"GO:0072487"(MSL complex)|interpro:IPR000953(Chromo domain)|interpro:IPR008676(MRG)|interpro:IPR016197(Chromo domain-like)|interpro:IPR025995|interpro:IPR026541|interpro:IPR037921|interpro:IPR038217|mint:Q8N5Y2|rcsb pdb:2Y0N|rcsb pdb:3OA6|rcsb pdb:3OB9|reactome:R-HSA-3214847|refseq:NP_001180199.1|refseq:NP_523352.1|refseq:NP_523353.2|refseq:NP_006791.2|refseq:NP_001269103.1|refseq:XP_005274497.1|dip:DIP-56857N	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S3|resulting-ptm:Q8N5Y2 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:EwhjYjowkZIAt4UyPcZBUtf9uak10116	rogid:uZsUcEHPwWI+o+d7aGwhfnxVltA9606	intact-crc:6285367EBD2204CF|rigid:J7iDtE2kLvh7TFWWyn8vu2Ng3LY	false	sufficient binding region:433-481(IPR013083)	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q62925	uniprotkb:Q13404	intact:EBI-636664	intact:EBI-1050671|uniprotkb:Q13403|uniprotkb:Q13532|uniprotkb:Q96H34|uniprotkb:Q9GZT0|uniprotkb:Q9GZW1|uniprotkb:Q9H4J3|uniprotkb:Q9H4J4|uniprotkb:Q9UKL1|uniprotkb:Q9UM48|uniprotkb:Q9UM49|uniprotkb:Q9UM50|uniprotkb:Q5TGE3|uniprotkb:E1P629|uniprotkb:Q5TGE0|ensembl:ENSP00000360739	psi-mi:m3k1_rat(display_long)|uniprotkb:MAPK/ERK kinase kinase 1(gene name synonym)|uniprotkb:Map3k1(gene name)|psi-mi:Map3k1(display_short)|uniprotkb:Mekk(gene name synonym)|uniprotkb:Mekk1(gene name synonym)	psi-mi:ub2v1_human(display_long)|uniprotkb:CROC-1(gene name synonym)|uniprotkb:TRAF6-regulated IKK activator 1 beta Uev1A(gene name synonym)|uniprotkb:P/OKcl.19(orf name)|uniprotkb:UBE2V1(gene name)|psi-mi:UBE2V1(display_short)|uniprotkb:CROC1(gene name synonym)|uniprotkb:UBE2V(gene name synonym)|uniprotkb:UEV1(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9972111|imex:IM-22822-98	author-confidence:Z-score = 5.14|author-confidence:Z-score = 10.77	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:620966|refseq:NP_446339.1|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR007527(Zinc finger, SWIM-type)|go:"GO:0000165"(MAPK cascade)|interpro:IPR016024(Armadillo-type fold)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0002011"(morphogenesis of an epithelial sheet)|go:"GO:0003382"(epithelial cell morphogenesis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004706"(JUN kinase kinase kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007254"(JNK cascade)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008432"(JUN kinase binding)|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0016020"(membrane)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0031434"(mitogen-activated protein kinase kinase binding)|go:"GO:0031941"(filamentous actin)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0042060"(wound healing)|go:"GO:0043010"(camera-type eye development)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046625"(sphingolipid binding)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050434"(positive regulation of viral transcription)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0061029"(eyelid development in camera-type eye)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|reactome:R-RNO-166058|reactome:R-RNO-2871796|reactome:R-RNO-975138|reactome:R-RNO-975871|interpro:IPR011989(Armadillo-like helical)|mint:Q62925	refseq:NP_001027459.1|refseq:NP_068823.2|refseq:NP_071887.1|refseq:NP_954595.1|refseq:NP_954673.1|refseq:NP_001244322.1|refseq:NP_001244323.1|refseq:NP_001244325.1|ensembl:ENSG00000244687(gene)|ensembl:ENST00000371674(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006282"(regulation of DNA repair)|go:"GO:0006301"(postreplication repair)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0030154"(cell differentiation)|go:"GO:0031371"(ubiquitin conjugating enzyme complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035370"(UBC13-UEV1A complex)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070534"(protein K63-linked ubiquitination)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|rcsb pdb:2A4D|rcsb pdb:2C2V|rcsb pdb:2HLW|rcsb pdb:6D6I|reactome:R-HSA-168638|reactome:R-HSA-168927|reactome:R-HSA-202424|reactome:R-HSA-2871837|reactome:R-HSA-445989|reactome:R-HSA-450302|reactome:R-HSA-450321|reactome:R-HSA-5607764|reactome:R-HSA-9020702|reactome:R-HSA-937039|reactome:R-HSA-937041|reactome:R-HSA-9646399|reactome:R-HSA-975110|reactome:R-HSA-975144|reactome:R-HSA-983168|dip:DIP-41911N	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S3|resulting-ptm:Q8N5Y2 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:EwhjYjowkZIAt4UyPcZBUtf9uak10116	rogid:x95N7Dj2KIqu5gySX59xLmfthUg9606	intact-crc:6285367EBD2204CF|rigid:J7iDtE2kLvh7TFWWyn8vu2Ng3LY	false	sufficient binding region:433-481(IPR013083)	his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q62925	uniprotkb:P22314	intact:EBI-636664	intact:EBI-709688|uniprotkb:Q96E13|uniprotkb:Q5JRR8|ensembl:ENSP00000338413|ensembl:ENSP00000366568	psi-mi:m3k1_rat(display_long)|uniprotkb:MAPK/ERK kinase kinase 1(gene name synonym)|uniprotkb:Map3k1(gene name)|psi-mi:Map3k1(display_short)|uniprotkb:Mekk(gene name synonym)|uniprotkb:Mekk1(gene name synonym)	psi-mi:uba1_human(display_long)|uniprotkb:Ubiquitin-activating enzyme E1(gene name synonym)|uniprotkb:Protein A1S9(gene name synonym)|uniprotkb:UBA1(gene name)|psi-mi:UBA1(display_short)|uniprotkb:A1S9T(gene name synonym)|uniprotkb:UBE1(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9972111|imex:IM-22822-98	author-confidence:Z-score = 5.14|author-confidence:Z-score = 10.77	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:620966|refseq:NP_446339.1|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR007527(Zinc finger, SWIM-type)|go:"GO:0000165"(MAPK cascade)|interpro:IPR016024(Armadillo-type fold)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0002011"(morphogenesis of an epithelial sheet)|go:"GO:0003382"(epithelial cell morphogenesis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004706"(JUN kinase kinase kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007254"(JNK cascade)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008432"(JUN kinase binding)|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0016020"(membrane)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0031434"(mitogen-activated protein kinase kinase binding)|go:"GO:0031941"(filamentous actin)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0042060"(wound healing)|go:"GO:0043010"(camera-type eye development)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046625"(sphingolipid binding)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050434"(positive regulation of viral transcription)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0061029"(eyelid development in camera-type eye)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|reactome:R-RNO-166058|reactome:R-RNO-2871796|reactome:R-RNO-975138|reactome:R-RNO-975871|interpro:IPR011989(Armadillo-like helical)|mint:Q62925	refseq:NP_003325.2|refseq:NP_695012.1|refseq:XP_016885269.1|refseq:XP_016885270.1|dip:DIP-33686N|ensembl:ENSG00000130985(gene)|ensembl:ENST00000335972(transcript)|ensembl:ENST00000377351(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0004839"(ubiquitin activating enzyme activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0032446"(protein modification by small protein conjugation)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000011(Ubiquitin-activating enzyme, E1)|interpro:IPR000594(UBA/THIF-type NAD/FAD binding fold)|interpro:IPR018074|interpro:IPR018075|interpro:IPR018965|interpro:IPR019572|interpro:IPR032418|interpro:IPR032420|interpro:IPR033127|interpro:IPR035985|interpro:IPR038252|interpro:IPR042063|interpro:IPR042302|interpro:IPR042449|mint:P22314|rcsb pdb:4P22|rcsb pdb:6DC6|reactome:R-HSA-8866652|reactome:R-HSA-983168	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S3|resulting-ptm:Q8N5Y2 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:EwhjYjowkZIAt4UyPcZBUtf9uak10116	rogid:q+vEeA0XLST0Zz173bmEt0dNbDE9606	intact-crc:6285367EBD2204CF|rigid:J7iDtE2kLvh7TFWWyn8vu2Ng3LY	false	sufficient binding region:433-481(IPR013083)	his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q62925	uniprotkb:P61088	intact:EBI-636664	intact:EBI-1052908|uniprotkb:Q16781|uniprotkb:Q53Y81|ensembl:ENSP00000316176	psi-mi:m3k1_rat(display_long)|uniprotkb:MAPK/ERK kinase kinase 1(gene name synonym)|uniprotkb:Map3k1(gene name)|psi-mi:Map3k1(display_short)|uniprotkb:Mekk(gene name synonym)|uniprotkb:Mekk1(gene name synonym)	psi-mi:ube2n_human(display_long)|uniprotkb:Ubiquitin-protein ligase N(gene name synonym)|uniprotkb:Ubiquitin carrier protein N(gene name synonym)|uniprotkb:Ubc13(gene name synonym)|uniprotkb:Bendless-like ubiquitin-conjugating enzyme(gene name synonym)|uniprotkb:UBE2N(gene name)|psi-mi:UBE2N(display_short)|uniprotkb:BLU(gene name synonym)|uniprotkb:UbcH13(gene name synonym)|uniprotkb:E2 ubiquitin-conjugating enzyme N(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9972111|imex:IM-22822-98	author-confidence:Z-score = 5.14|author-confidence:Z-score = 10.77	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:620966|refseq:NP_446339.1|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR007527(Zinc finger, SWIM-type)|go:"GO:0000165"(MAPK cascade)|interpro:IPR016024(Armadillo-type fold)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0002011"(morphogenesis of an epithelial sheet)|go:"GO:0003382"(epithelial cell morphogenesis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004706"(JUN kinase kinase kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007254"(JNK cascade)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008432"(JUN kinase binding)|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0016020"(membrane)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0031434"(mitogen-activated protein kinase kinase binding)|go:"GO:0031941"(filamentous actin)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0042060"(wound healing)|go:"GO:0043010"(camera-type eye development)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046625"(sphingolipid binding)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050434"(positive regulation of viral transcription)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0061029"(eyelid development in camera-type eye)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|reactome:R-RNO-166058|reactome:R-RNO-2871796|reactome:R-RNO-975138|reactome:R-RNO-975871|interpro:IPR011989(Armadillo-like helical)|mint:Q62925	refseq:NP_003339.1|dip:DIP-29829N|ensembl:ENSG00000177889(gene)|ensembl:ENST00000318066(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000729"(DNA double-strand break processing)|go:"GO:0001650"(fibrillar center)|go:"GO:0003723"(RNA binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006282"(regulation of DNA repair)|go:"GO:0006301"(postreplication repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016574"(histone ubiquitination)|go:"GO:0031058"(positive regulation of histone modification)|go:"GO:0031372"(UBC13-MMS2 complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033182"(regulation of histone ubiquitination)|go:"GO:0035370"(UBC13-UEV1A complex)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0061631"(ubiquitin conjugating enzyme activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070534"(protein K63-linked ubiquitination)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|interpro:IPR023313|rcsb pdb:1J7D|rcsb pdb:2C2V|rcsb pdb:3HCT|rcsb pdb:3HCU|rcsb pdb:3VON|rcsb pdb:3W31|rcsb pdb:4DHI|rcsb pdb:4DHJ|rcsb pdb:4DHZ|rcsb pdb:4IP3|rcsb pdb:4NR3|rcsb pdb:4NRG|rcsb pdb:4NRI|rcsb pdb:4ONL|rcsb pdb:4ONM|rcsb pdb:4ONN|rcsb pdb:4ORH|rcsb pdb:4TKP|rcsb pdb:4WHV|rcsb pdb:5AIT|rcsb pdb:5AIU|rcsb pdb:5EYA|rcsb pdb:5H7S|rcsb pdb:5VNZ|rcsb pdb:5VO0|rcsb pdb:5YWR|rcsb pdb:6D6I|rcsb pdb:6JKY|rcsb pdb:6KFP|rcsb pdb:6KG6|rcsb pdb:6KL4|rcsb pdb:6LP2|rcsb pdb:6P5B|rcsb pdb:6S53|reactome:R-HSA-168927|reactome:R-HSA-202424|reactome:R-HSA-2871837|reactome:R-HSA-445989|reactome:R-HSA-450302|reactome:R-HSA-450321|reactome:R-HSA-5607764|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-5696395|reactome:R-HSA-69473|reactome:R-HSA-8866654|reactome:R-HSA-9020702|reactome:R-HSA-937039|reactome:R-HSA-937041|reactome:R-HSA-9646399|reactome:R-HSA-975110|reactome:R-HSA-975144|reactome:R-HSA-983168|rcsb pdb:6ULH|rcsb pdb:6UMP|rcsb pdb:6UMS|rcsb pdb:7BBD|rcsb pdb:7BBF|rcsb pdb:7BXG|reactome:R-HSA-1169408|reactome:R-HSA-168638	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S3|resulting-ptm:Q8N5Y2 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:EwhjYjowkZIAt4UyPcZBUtf9uak10116	rogid:dqdszHlq5FLPHC6UWX6uvkC6Yz89606	intact-crc:6285367EBD2204CF|rigid:J7iDtE2kLvh7TFWWyn8vu2Ng3LY	false	sufficient binding region:433-481(IPR013083)	his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q8NEG7	uniprotkb:Q62925	intact:EBI-3957009|uniprotkb:A6X8I5|ensembl:ENSP00000391524	intact:EBI-636664	psi-mi:den6b_human(display_long)|uniprotkb:DENND6B(gene name)|psi-mi:DENND6B(display_short)|uniprotkb:DENN domain-containing protein 6B(gene name synonym)|uniprotkb:FAM116B(gene name synonym)	psi-mi:m3k1_rat(display_long)|uniprotkb:MAPK/ERK kinase kinase 1(gene name synonym)|uniprotkb:Map3k1(gene name)|psi-mi:Map3k1(display_short)|uniprotkb:Mekk(gene name synonym)|uniprotkb:Mekk1(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9972162|imex:IM-22822-100	author-confidence:Z-score = 3.50	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR024224|interpro:IPR037516|reactome:R-HSA-8876198|refseq:NP_001001794.3|ensembl:ENSG00000205593(gene)|ensembl:ENST00000413817(transcript)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005829"(cytosol)|go:"GO:0055037"(recycling endosome)|interpro:IPR018307	rgd:620966|refseq:NP_446339.1|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR007527(Zinc finger, SWIM-type)|go:"GO:0000165"(MAPK cascade)|interpro:IPR016024(Armadillo-type fold)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0002011"(morphogenesis of an epithelial sheet)|go:"GO:0003382"(epithelial cell morphogenesis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004706"(JUN kinase kinase kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007254"(JNK cascade)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008432"(JUN kinase binding)|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0016020"(membrane)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0031434"(mitogen-activated protein kinase kinase binding)|go:"GO:0031941"(filamentous actin)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0042060"(wound healing)|go:"GO:0043010"(camera-type eye development)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046625"(sphingolipid binding)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050434"(positive regulation of viral transcription)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0061029"(eyelid development in camera-type eye)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|reactome:R-RNO-166058|reactome:R-RNO-2871796|reactome:R-RNO-975138|reactome:R-RNO-975871|interpro:IPR011989(Armadillo-like helical)|mint:Q62925	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S3|resulting-ptm:Q8NEG7 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:2J4E9XtJ5uKlO4xfX/27xRqv3ZY9606	rogid:EwhjYjowkZIAt4UyPcZBUtf9uak10116	intact-crc:68730BC4E8FFF1E5|rigid:iWBguV1NvZ6+rP0T8QrMxnJ+mIo	false	-	sufficient binding region:433-481(IPR013083)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q8NEG7	uniprotkb:Q13404	intact:EBI-3957009|uniprotkb:A6X8I5|ensembl:ENSP00000391524	intact:EBI-1050671|uniprotkb:Q13403|uniprotkb:Q13532|uniprotkb:Q96H34|uniprotkb:Q9GZT0|uniprotkb:Q9GZW1|uniprotkb:Q9H4J3|uniprotkb:Q9H4J4|uniprotkb:Q9UKL1|uniprotkb:Q9UM48|uniprotkb:Q9UM49|uniprotkb:Q9UM50|uniprotkb:Q5TGE3|uniprotkb:E1P629|uniprotkb:Q5TGE0|ensembl:ENSP00000360739	psi-mi:den6b_human(display_long)|uniprotkb:DENND6B(gene name)|psi-mi:DENND6B(display_short)|uniprotkb:DENN domain-containing protein 6B(gene name synonym)|uniprotkb:FAM116B(gene name synonym)	psi-mi:ub2v1_human(display_long)|uniprotkb:CROC-1(gene name synonym)|uniprotkb:TRAF6-regulated IKK activator 1 beta Uev1A(gene name synonym)|uniprotkb:P/OKcl.19(orf name)|uniprotkb:UBE2V1(gene name)|psi-mi:UBE2V1(display_short)|uniprotkb:CROC1(gene name synonym)|uniprotkb:UBE2V(gene name synonym)|uniprotkb:UEV1(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9972162|imex:IM-22822-100	author-confidence:Z-score = 3.50	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR024224|interpro:IPR037516|reactome:R-HSA-8876198|refseq:NP_001001794.3|ensembl:ENSG00000205593(gene)|ensembl:ENST00000413817(transcript)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005829"(cytosol)|go:"GO:0055037"(recycling endosome)|interpro:IPR018307	refseq:NP_001027459.1|refseq:NP_068823.2|refseq:NP_071887.1|refseq:NP_954595.1|refseq:NP_954673.1|refseq:NP_001244322.1|refseq:NP_001244323.1|refseq:NP_001244325.1|ensembl:ENSG00000244687(gene)|ensembl:ENST00000371674(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006282"(regulation of DNA repair)|go:"GO:0006301"(postreplication repair)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0030154"(cell differentiation)|go:"GO:0031371"(ubiquitin conjugating enzyme complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035370"(UBC13-UEV1A complex)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070534"(protein K63-linked ubiquitination)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|rcsb pdb:2A4D|rcsb pdb:2C2V|rcsb pdb:2HLW|rcsb pdb:6D6I|reactome:R-HSA-168638|reactome:R-HSA-168927|reactome:R-HSA-202424|reactome:R-HSA-2871837|reactome:R-HSA-445989|reactome:R-HSA-450302|reactome:R-HSA-450321|reactome:R-HSA-5607764|reactome:R-HSA-9020702|reactome:R-HSA-937039|reactome:R-HSA-937041|reactome:R-HSA-9646399|reactome:R-HSA-975110|reactome:R-HSA-975144|reactome:R-HSA-983168|dip:DIP-41911N	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S3|resulting-ptm:Q8NEG7 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:2J4E9XtJ5uKlO4xfX/27xRqv3ZY9606	rogid:x95N7Dj2KIqu5gySX59xLmfthUg9606	intact-crc:68730BC4E8FFF1E5|rigid:iWBguV1NvZ6+rP0T8QrMxnJ+mIo	false	-	his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q8NEG7	uniprotkb:P22314	intact:EBI-3957009|uniprotkb:A6X8I5|ensembl:ENSP00000391524	intact:EBI-709688|uniprotkb:Q96E13|uniprotkb:Q5JRR8|ensembl:ENSP00000338413|ensembl:ENSP00000366568	psi-mi:den6b_human(display_long)|uniprotkb:DENND6B(gene name)|psi-mi:DENND6B(display_short)|uniprotkb:DENN domain-containing protein 6B(gene name synonym)|uniprotkb:FAM116B(gene name synonym)	psi-mi:uba1_human(display_long)|uniprotkb:Ubiquitin-activating enzyme E1(gene name synonym)|uniprotkb:Protein A1S9(gene name synonym)|uniprotkb:UBA1(gene name)|psi-mi:UBA1(display_short)|uniprotkb:A1S9T(gene name synonym)|uniprotkb:UBE1(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9972162|imex:IM-22822-100	author-confidence:Z-score = 3.50	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR024224|interpro:IPR037516|reactome:R-HSA-8876198|refseq:NP_001001794.3|ensembl:ENSG00000205593(gene)|ensembl:ENST00000413817(transcript)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005829"(cytosol)|go:"GO:0055037"(recycling endosome)|interpro:IPR018307	refseq:NP_003325.2|refseq:NP_695012.1|refseq:XP_016885269.1|refseq:XP_016885270.1|dip:DIP-33686N|ensembl:ENSG00000130985(gene)|ensembl:ENST00000335972(transcript)|ensembl:ENST00000377351(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0004839"(ubiquitin activating enzyme activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0032446"(protein modification by small protein conjugation)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000011(Ubiquitin-activating enzyme, E1)|interpro:IPR000594(UBA/THIF-type NAD/FAD binding fold)|interpro:IPR018074|interpro:IPR018075|interpro:IPR018965|interpro:IPR019572|interpro:IPR032418|interpro:IPR032420|interpro:IPR033127|interpro:IPR035985|interpro:IPR038252|interpro:IPR042063|interpro:IPR042302|interpro:IPR042449|mint:P22314|rcsb pdb:4P22|rcsb pdb:6DC6|reactome:R-HSA-8866652|reactome:R-HSA-983168	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S3|resulting-ptm:Q8NEG7 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:2J4E9XtJ5uKlO4xfX/27xRqv3ZY9606	rogid:q+vEeA0XLST0Zz173bmEt0dNbDE9606	intact-crc:68730BC4E8FFF1E5|rigid:iWBguV1NvZ6+rP0T8QrMxnJ+mIo	false	-	his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q8NEG7	uniprotkb:P61088	intact:EBI-3957009|uniprotkb:A6X8I5|ensembl:ENSP00000391524	intact:EBI-1052908|uniprotkb:Q16781|uniprotkb:Q53Y81|ensembl:ENSP00000316176	psi-mi:den6b_human(display_long)|uniprotkb:DENND6B(gene name)|psi-mi:DENND6B(display_short)|uniprotkb:DENN domain-containing protein 6B(gene name synonym)|uniprotkb:FAM116B(gene name synonym)	psi-mi:ube2n_human(display_long)|uniprotkb:Ubiquitin-protein ligase N(gene name synonym)|uniprotkb:Ubiquitin carrier protein N(gene name synonym)|uniprotkb:Ubc13(gene name synonym)|uniprotkb:Bendless-like ubiquitin-conjugating enzyme(gene name synonym)|uniprotkb:UBE2N(gene name)|psi-mi:UBE2N(display_short)|uniprotkb:BLU(gene name synonym)|uniprotkb:UbcH13(gene name synonym)|uniprotkb:E2 ubiquitin-conjugating enzyme N(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9972162|imex:IM-22822-100	author-confidence:Z-score = 3.50	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR024224|interpro:IPR037516|reactome:R-HSA-8876198|refseq:NP_001001794.3|ensembl:ENSG00000205593(gene)|ensembl:ENST00000413817(transcript)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005829"(cytosol)|go:"GO:0055037"(recycling endosome)|interpro:IPR018307	refseq:NP_003339.1|dip:DIP-29829N|ensembl:ENSG00000177889(gene)|ensembl:ENST00000318066(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000729"(DNA double-strand break processing)|go:"GO:0001650"(fibrillar center)|go:"GO:0003723"(RNA binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006282"(regulation of DNA repair)|go:"GO:0006301"(postreplication repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016574"(histone ubiquitination)|go:"GO:0031058"(positive regulation of histone modification)|go:"GO:0031372"(UBC13-MMS2 complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033182"(regulation of histone ubiquitination)|go:"GO:0035370"(UBC13-UEV1A complex)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0061631"(ubiquitin conjugating enzyme activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070534"(protein K63-linked ubiquitination)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|interpro:IPR023313|rcsb pdb:1J7D|rcsb pdb:2C2V|rcsb pdb:3HCT|rcsb pdb:3HCU|rcsb pdb:3VON|rcsb pdb:3W31|rcsb pdb:4DHI|rcsb pdb:4DHJ|rcsb pdb:4DHZ|rcsb pdb:4IP3|rcsb pdb:4NR3|rcsb pdb:4NRG|rcsb pdb:4NRI|rcsb pdb:4ONL|rcsb pdb:4ONM|rcsb pdb:4ONN|rcsb pdb:4ORH|rcsb pdb:4TKP|rcsb pdb:4WHV|rcsb pdb:5AIT|rcsb pdb:5AIU|rcsb pdb:5EYA|rcsb pdb:5H7S|rcsb pdb:5VNZ|rcsb pdb:5VO0|rcsb pdb:5YWR|rcsb pdb:6D6I|rcsb pdb:6JKY|rcsb pdb:6KFP|rcsb pdb:6KG6|rcsb pdb:6KL4|rcsb pdb:6LP2|rcsb pdb:6P5B|rcsb pdb:6S53|reactome:R-HSA-168927|reactome:R-HSA-202424|reactome:R-HSA-2871837|reactome:R-HSA-445989|reactome:R-HSA-450302|reactome:R-HSA-450321|reactome:R-HSA-5607764|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-5696395|reactome:R-HSA-69473|reactome:R-HSA-8866654|reactome:R-HSA-9020702|reactome:R-HSA-937039|reactome:R-HSA-937041|reactome:R-HSA-9646399|reactome:R-HSA-975110|reactome:R-HSA-975144|reactome:R-HSA-983168|rcsb pdb:6ULH|rcsb pdb:6UMP|rcsb pdb:6UMS|rcsb pdb:7BBD|rcsb pdb:7BBF|rcsb pdb:7BXG|reactome:R-HSA-1169408|reactome:R-HSA-168638	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S3|resulting-ptm:Q8NEG7 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:2J4E9XtJ5uKlO4xfX/27xRqv3ZY9606	rogid:dqdszHlq5FLPHC6UWX6uvkC6Yz89606	intact-crc:68730BC4E8FFF1E5|rigid:iWBguV1NvZ6+rP0T8QrMxnJ+mIo	false	-	his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q62925	uniprotkb:Q8NFZ5	intact:EBI-636664	intact:EBI-359372|uniprotkb:Q7L5L2|uniprotkb:Q9BQR6|uniprotkb:Q9H682|uniprotkb:B1AKS4|uniprotkb:B3KTY8|uniprotkb:D3DVQ9|ensembl:ENSP00000321203	psi-mi:m3k1_rat(display_long)|uniprotkb:MAPK/ERK kinase kinase 1(gene name synonym)|uniprotkb:Map3k1(gene name)|psi-mi:Map3k1(display_short)|uniprotkb:Mekk(gene name synonym)|uniprotkb:Mekk1(gene name synonym)	psi-mi:tnip2_human(display_long)|uniprotkb:TNIP2(gene name)|psi-mi:TNIP2(display_short)|uniprotkb:ABIN2(gene name synonym)|uniprotkb:FLIP1(gene name synonym)|uniprotkb:Fetal liver LKB1-interacting protein(gene name synonym)|uniprotkb:A20-binding inhibitor of NF-kappa-B activation 2(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9972187|imex:IM-22822-101	author-confidence:Z-score = 10.76|author-confidence:Z-score = 10.77	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:620966|refseq:NP_446339.1|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR007527(Zinc finger, SWIM-type)|go:"GO:0000165"(MAPK cascade)|interpro:IPR016024(Armadillo-type fold)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0002011"(morphogenesis of an epithelial sheet)|go:"GO:0003382"(epithelial cell morphogenesis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004706"(JUN kinase kinase kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007254"(JNK cascade)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008432"(JUN kinase binding)|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0016020"(membrane)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0031434"(mitogen-activated protein kinase kinase binding)|go:"GO:0031941"(filamentous actin)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0042060"(wound healing)|go:"GO:0043010"(camera-type eye development)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046625"(sphingolipid binding)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050434"(positive regulation of viral transcription)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0061029"(eyelid development in camera-type eye)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|reactome:R-RNO-166058|reactome:R-RNO-2871796|reactome:R-RNO-975138|reactome:R-RNO-975871|interpro:IPR011989(Armadillo-like helical)|mint:Q62925	refseq:NP_001154999.1|refseq:NP_077285.3|ensembl:ENSG00000168884(gene)|ensembl:ENST00000315423(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0019901"(protein kinase binding)|go:"GO:0023035"(CD40 signaling pathway)|go:"GO:0031593"(polyubiquitin modification-dependent protein binding)|go:"GO:0034134"(toll-like receptor 2 signaling pathway)|go:"GO:0034138"(toll-like receptor 3 signaling pathway)|go:"GO:0034162"(toll-like receptor 9 signaling pathway)|go:"GO:0043032"(positive regulation of macrophage activation)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0050871"(positive regulation of B cell activation)|go:"GO:0070498"(interleukin-1-mediated signaling pathway)|go:"GO:0070530"(K63-linked polyubiquitin modification-dependent protein binding)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:2000352"(negative regulation of endothelial cell apoptotic process)|interpro:IPR022008|interpro:IPR034735|mint:Q8NFZ5|rcsb pdb:5H07|reactome:R-HSA-5684264|reactome:R-HSA-5689896|refseq:NP_001278945.1|dip:DIP-27617N	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S3|resulting-ptm:Q8NFZ5 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:EwhjYjowkZIAt4UyPcZBUtf9uak10116	rogid:K9Ee06++lTFEHy1d/3tMu6uwyU09606	intact-crc:1521157276042F57|rigid:KV2dFLRu0QI+jfq4y8sr/ue6K2E	false	sufficient binding region:433-481(IPR013083)	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q62925	uniprotkb:Q13404	intact:EBI-636664	intact:EBI-1050671|uniprotkb:Q13403|uniprotkb:Q13532|uniprotkb:Q96H34|uniprotkb:Q9GZT0|uniprotkb:Q9GZW1|uniprotkb:Q9H4J3|uniprotkb:Q9H4J4|uniprotkb:Q9UKL1|uniprotkb:Q9UM48|uniprotkb:Q9UM49|uniprotkb:Q9UM50|uniprotkb:Q5TGE3|uniprotkb:E1P629|uniprotkb:Q5TGE0|ensembl:ENSP00000360739	psi-mi:m3k1_rat(display_long)|uniprotkb:MAPK/ERK kinase kinase 1(gene name synonym)|uniprotkb:Map3k1(gene name)|psi-mi:Map3k1(display_short)|uniprotkb:Mekk(gene name synonym)|uniprotkb:Mekk1(gene name synonym)	psi-mi:ub2v1_human(display_long)|uniprotkb:CROC-1(gene name synonym)|uniprotkb:TRAF6-regulated IKK activator 1 beta Uev1A(gene name synonym)|uniprotkb:P/OKcl.19(orf name)|uniprotkb:UBE2V1(gene name)|psi-mi:UBE2V1(display_short)|uniprotkb:CROC1(gene name synonym)|uniprotkb:UBE2V(gene name synonym)|uniprotkb:UEV1(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9972187|imex:IM-22822-101	author-confidence:Z-score = 10.76|author-confidence:Z-score = 10.77	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:620966|refseq:NP_446339.1|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR007527(Zinc finger, SWIM-type)|go:"GO:0000165"(MAPK cascade)|interpro:IPR016024(Armadillo-type fold)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0002011"(morphogenesis of an epithelial sheet)|go:"GO:0003382"(epithelial cell morphogenesis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004706"(JUN kinase kinase kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007254"(JNK cascade)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008432"(JUN kinase binding)|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0016020"(membrane)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0031434"(mitogen-activated protein kinase kinase binding)|go:"GO:0031941"(filamentous actin)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0042060"(wound healing)|go:"GO:0043010"(camera-type eye development)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046625"(sphingolipid binding)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050434"(positive regulation of viral transcription)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0061029"(eyelid development in camera-type eye)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|reactome:R-RNO-166058|reactome:R-RNO-2871796|reactome:R-RNO-975138|reactome:R-RNO-975871|interpro:IPR011989(Armadillo-like helical)|mint:Q62925	refseq:NP_001027459.1|refseq:NP_068823.2|refseq:NP_071887.1|refseq:NP_954595.1|refseq:NP_954673.1|refseq:NP_001244322.1|refseq:NP_001244323.1|refseq:NP_001244325.1|ensembl:ENSG00000244687(gene)|ensembl:ENST00000371674(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006282"(regulation of DNA repair)|go:"GO:0006301"(postreplication repair)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0030154"(cell differentiation)|go:"GO:0031371"(ubiquitin conjugating enzyme complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035370"(UBC13-UEV1A complex)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070534"(protein K63-linked ubiquitination)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|rcsb pdb:2A4D|rcsb pdb:2C2V|rcsb pdb:2HLW|rcsb pdb:6D6I|reactome:R-HSA-168638|reactome:R-HSA-168927|reactome:R-HSA-202424|reactome:R-HSA-2871837|reactome:R-HSA-445989|reactome:R-HSA-450302|reactome:R-HSA-450321|reactome:R-HSA-5607764|reactome:R-HSA-9020702|reactome:R-HSA-937039|reactome:R-HSA-937041|reactome:R-HSA-9646399|reactome:R-HSA-975110|reactome:R-HSA-975144|reactome:R-HSA-983168|dip:DIP-41911N	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S3|resulting-ptm:Q8NFZ5 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:EwhjYjowkZIAt4UyPcZBUtf9uak10116	rogid:x95N7Dj2KIqu5gySX59xLmfthUg9606	intact-crc:1521157276042F57|rigid:KV2dFLRu0QI+jfq4y8sr/ue6K2E	false	sufficient binding region:433-481(IPR013083)	his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q62925	uniprotkb:P22314	intact:EBI-636664	intact:EBI-709688|uniprotkb:Q96E13|uniprotkb:Q5JRR8|ensembl:ENSP00000338413|ensembl:ENSP00000366568	psi-mi:m3k1_rat(display_long)|uniprotkb:MAPK/ERK kinase kinase 1(gene name synonym)|uniprotkb:Map3k1(gene name)|psi-mi:Map3k1(display_short)|uniprotkb:Mekk(gene name synonym)|uniprotkb:Mekk1(gene name synonym)	psi-mi:uba1_human(display_long)|uniprotkb:Ubiquitin-activating enzyme E1(gene name synonym)|uniprotkb:Protein A1S9(gene name synonym)|uniprotkb:UBA1(gene name)|psi-mi:UBA1(display_short)|uniprotkb:A1S9T(gene name synonym)|uniprotkb:UBE1(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9972187|imex:IM-22822-101	author-confidence:Z-score = 10.76|author-confidence:Z-score = 10.77	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:620966|refseq:NP_446339.1|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR007527(Zinc finger, SWIM-type)|go:"GO:0000165"(MAPK cascade)|interpro:IPR016024(Armadillo-type fold)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0002011"(morphogenesis of an epithelial sheet)|go:"GO:0003382"(epithelial cell morphogenesis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004706"(JUN kinase kinase kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007254"(JNK cascade)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008432"(JUN kinase binding)|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0016020"(membrane)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0031434"(mitogen-activated protein kinase kinase binding)|go:"GO:0031941"(filamentous actin)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0042060"(wound healing)|go:"GO:0043010"(camera-type eye development)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046625"(sphingolipid binding)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050434"(positive regulation of viral transcription)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0061029"(eyelid development in camera-type eye)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|reactome:R-RNO-166058|reactome:R-RNO-2871796|reactome:R-RNO-975138|reactome:R-RNO-975871|interpro:IPR011989(Armadillo-like helical)|mint:Q62925	refseq:NP_003325.2|refseq:NP_695012.1|refseq:XP_016885269.1|refseq:XP_016885270.1|dip:DIP-33686N|ensembl:ENSG00000130985(gene)|ensembl:ENST00000335972(transcript)|ensembl:ENST00000377351(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0004839"(ubiquitin activating enzyme activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0032446"(protein modification by small protein conjugation)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000011(Ubiquitin-activating enzyme, E1)|interpro:IPR000594(UBA/THIF-type NAD/FAD binding fold)|interpro:IPR018074|interpro:IPR018075|interpro:IPR018965|interpro:IPR019572|interpro:IPR032418|interpro:IPR032420|interpro:IPR033127|interpro:IPR035985|interpro:IPR038252|interpro:IPR042063|interpro:IPR042302|interpro:IPR042449|mint:P22314|rcsb pdb:4P22|rcsb pdb:6DC6|reactome:R-HSA-8866652|reactome:R-HSA-983168	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S3|resulting-ptm:Q8NFZ5 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:EwhjYjowkZIAt4UyPcZBUtf9uak10116	rogid:q+vEeA0XLST0Zz173bmEt0dNbDE9606	intact-crc:1521157276042F57|rigid:KV2dFLRu0QI+jfq4y8sr/ue6K2E	false	sufficient binding region:433-481(IPR013083)	his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q62925	uniprotkb:P61088	intact:EBI-636664	intact:EBI-1052908|uniprotkb:Q16781|uniprotkb:Q53Y81|ensembl:ENSP00000316176	psi-mi:m3k1_rat(display_long)|uniprotkb:MAPK/ERK kinase kinase 1(gene name synonym)|uniprotkb:Map3k1(gene name)|psi-mi:Map3k1(display_short)|uniprotkb:Mekk(gene name synonym)|uniprotkb:Mekk1(gene name synonym)	psi-mi:ube2n_human(display_long)|uniprotkb:Ubiquitin-protein ligase N(gene name synonym)|uniprotkb:Ubiquitin carrier protein N(gene name synonym)|uniprotkb:Ubc13(gene name synonym)|uniprotkb:Bendless-like ubiquitin-conjugating enzyme(gene name synonym)|uniprotkb:UBE2N(gene name)|psi-mi:UBE2N(display_short)|uniprotkb:BLU(gene name synonym)|uniprotkb:UbcH13(gene name synonym)|uniprotkb:E2 ubiquitin-conjugating enzyme N(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9972187|imex:IM-22822-101	author-confidence:Z-score = 10.76|author-confidence:Z-score = 10.77	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:620966|refseq:NP_446339.1|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR007527(Zinc finger, SWIM-type)|go:"GO:0000165"(MAPK cascade)|interpro:IPR016024(Armadillo-type fold)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0002011"(morphogenesis of an epithelial sheet)|go:"GO:0003382"(epithelial cell morphogenesis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004706"(JUN kinase kinase kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007254"(JNK cascade)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008432"(JUN kinase binding)|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0016020"(membrane)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0031434"(mitogen-activated protein kinase kinase binding)|go:"GO:0031941"(filamentous actin)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0042060"(wound healing)|go:"GO:0043010"(camera-type eye development)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046625"(sphingolipid binding)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050434"(positive regulation of viral transcription)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0061029"(eyelid development in camera-type eye)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|reactome:R-RNO-166058|reactome:R-RNO-2871796|reactome:R-RNO-975138|reactome:R-RNO-975871|interpro:IPR011989(Armadillo-like helical)|mint:Q62925	refseq:NP_003339.1|dip:DIP-29829N|ensembl:ENSG00000177889(gene)|ensembl:ENST00000318066(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000729"(DNA double-strand break processing)|go:"GO:0001650"(fibrillar center)|go:"GO:0003723"(RNA binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006282"(regulation of DNA repair)|go:"GO:0006301"(postreplication repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016574"(histone ubiquitination)|go:"GO:0031058"(positive regulation of histone modification)|go:"GO:0031372"(UBC13-MMS2 complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033182"(regulation of histone ubiquitination)|go:"GO:0035370"(UBC13-UEV1A complex)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0061631"(ubiquitin conjugating enzyme activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070534"(protein K63-linked ubiquitination)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|interpro:IPR023313|rcsb pdb:1J7D|rcsb pdb:2C2V|rcsb pdb:3HCT|rcsb pdb:3HCU|rcsb pdb:3VON|rcsb pdb:3W31|rcsb pdb:4DHI|rcsb pdb:4DHJ|rcsb pdb:4DHZ|rcsb pdb:4IP3|rcsb pdb:4NR3|rcsb pdb:4NRG|rcsb pdb:4NRI|rcsb pdb:4ONL|rcsb pdb:4ONM|rcsb pdb:4ONN|rcsb pdb:4ORH|rcsb pdb:4TKP|rcsb pdb:4WHV|rcsb pdb:5AIT|rcsb pdb:5AIU|rcsb pdb:5EYA|rcsb pdb:5H7S|rcsb pdb:5VNZ|rcsb pdb:5VO0|rcsb pdb:5YWR|rcsb pdb:6D6I|rcsb pdb:6JKY|rcsb pdb:6KFP|rcsb pdb:6KG6|rcsb pdb:6KL4|rcsb pdb:6LP2|rcsb pdb:6P5B|rcsb pdb:6S53|reactome:R-HSA-168927|reactome:R-HSA-202424|reactome:R-HSA-2871837|reactome:R-HSA-445989|reactome:R-HSA-450302|reactome:R-HSA-450321|reactome:R-HSA-5607764|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-5696395|reactome:R-HSA-69473|reactome:R-HSA-8866654|reactome:R-HSA-9020702|reactome:R-HSA-937039|reactome:R-HSA-937041|reactome:R-HSA-9646399|reactome:R-HSA-975110|reactome:R-HSA-975144|reactome:R-HSA-983168|rcsb pdb:6ULH|rcsb pdb:6UMP|rcsb pdb:6UMS|rcsb pdb:7BBD|rcsb pdb:7BBF|rcsb pdb:7BXG|reactome:R-HSA-1169408|reactome:R-HSA-168638	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S3|resulting-ptm:Q8NFZ5 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:EwhjYjowkZIAt4UyPcZBUtf9uak10116	rogid:dqdszHlq5FLPHC6UWX6uvkC6Yz89606	intact-crc:1521157276042F57|rigid:KV2dFLRu0QI+jfq4y8sr/ue6K2E	false	sufficient binding region:433-481(IPR013083)	his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q62925	uniprotkb:Q8TBN0	intact:EBI-636664	intact:EBI-743796|uniprotkb:Q86V32|uniprotkb:Q9P1Q8|ensembl:ENSP00000378313	psi-mi:m3k1_rat(display_long)|uniprotkb:MAPK/ERK kinase kinase 1(gene name synonym)|uniprotkb:Map3k1(gene name)|psi-mi:Map3k1(display_short)|uniprotkb:Mekk(gene name synonym)|uniprotkb:Mekk1(gene name synonym)	psi-mi:r3gef_human(display_long)|uniprotkb:Rab-3A-interacting-like protein 1(gene name synonym)|uniprotkb:Rabin3-like 1(gene name synonym)|uniprotkb:RAB3IL1(gene name)|psi-mi:RAB3IL1(display_short)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9972238|imex:IM-22822-103	author-confidence:Z-score = 11.25	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:620966|refseq:NP_446339.1|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR007527(Zinc finger, SWIM-type)|go:"GO:0000165"(MAPK cascade)|interpro:IPR016024(Armadillo-type fold)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0002011"(morphogenesis of an epithelial sheet)|go:"GO:0003382"(epithelial cell morphogenesis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004706"(JUN kinase kinase kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007254"(JNK cascade)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008432"(JUN kinase binding)|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0016020"(membrane)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0031434"(mitogen-activated protein kinase kinase binding)|go:"GO:0031941"(filamentous actin)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0042060"(wound healing)|go:"GO:0043010"(camera-type eye development)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046625"(sphingolipid binding)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050434"(positive regulation of viral transcription)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0061029"(eyelid development in camera-type eye)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|reactome:R-RNO-166058|reactome:R-RNO-2871796|reactome:R-RNO-975138|reactome:R-RNO-975871|interpro:IPR011989(Armadillo-like helical)|mint:Q62925	refseq:NP_037533.2|refseq:NP_001258615.1|ensembl:ENSG00000167994(gene)|ensembl:ENST00000394836(transcript)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005829"(cytosol)|go:"GO:0006887"(exocytosis)|go:"GO:0015031"(protein transport)|go:"GO:0042802"(identical protein binding)|go:"GO:0070319"(Golgi to plasma membrane transport vesicle)|interpro:IPR009449(GDPGTP exchange factor Sec2p)|interpro:IPR040351|rcsb pdb:4LI0|reactome:R-HSA-8876198	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S3|resulting-ptm:Q8TBN0 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:EwhjYjowkZIAt4UyPcZBUtf9uak10116	rogid:kT4iWSZ+jRCNm3fDdDR5VhdF81o9606	intact-crc:DEB1E4271DD4E351|rigid:2kPXBMFm12TfkLjVnf4Y20dMuRQ	false	sufficient binding region:433-481(IPR013083)	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q62925	uniprotkb:Q13404	intact:EBI-636664	intact:EBI-1050671|uniprotkb:Q13403|uniprotkb:Q13532|uniprotkb:Q96H34|uniprotkb:Q9GZT0|uniprotkb:Q9GZW1|uniprotkb:Q9H4J3|uniprotkb:Q9H4J4|uniprotkb:Q9UKL1|uniprotkb:Q9UM48|uniprotkb:Q9UM49|uniprotkb:Q9UM50|uniprotkb:Q5TGE3|uniprotkb:E1P629|uniprotkb:Q5TGE0|ensembl:ENSP00000360739	psi-mi:m3k1_rat(display_long)|uniprotkb:MAPK/ERK kinase kinase 1(gene name synonym)|uniprotkb:Map3k1(gene name)|psi-mi:Map3k1(display_short)|uniprotkb:Mekk(gene name synonym)|uniprotkb:Mekk1(gene name synonym)	psi-mi:ub2v1_human(display_long)|uniprotkb:CROC-1(gene name synonym)|uniprotkb:TRAF6-regulated IKK activator 1 beta Uev1A(gene name synonym)|uniprotkb:P/OKcl.19(orf name)|uniprotkb:UBE2V1(gene name)|psi-mi:UBE2V1(display_short)|uniprotkb:CROC1(gene name synonym)|uniprotkb:UBE2V(gene name synonym)|uniprotkb:UEV1(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9972238|imex:IM-22822-103	author-confidence:Z-score = 11.25	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:620966|refseq:NP_446339.1|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR007527(Zinc finger, SWIM-type)|go:"GO:0000165"(MAPK cascade)|interpro:IPR016024(Armadillo-type fold)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0002011"(morphogenesis of an epithelial sheet)|go:"GO:0003382"(epithelial cell morphogenesis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004706"(JUN kinase kinase kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007254"(JNK cascade)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008432"(JUN kinase binding)|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0016020"(membrane)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0031434"(mitogen-activated protein kinase kinase binding)|go:"GO:0031941"(filamentous actin)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0042060"(wound healing)|go:"GO:0043010"(camera-type eye development)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046625"(sphingolipid binding)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050434"(positive regulation of viral transcription)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0061029"(eyelid development in camera-type eye)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|reactome:R-RNO-166058|reactome:R-RNO-2871796|reactome:R-RNO-975138|reactome:R-RNO-975871|interpro:IPR011989(Armadillo-like helical)|mint:Q62925	refseq:NP_001027459.1|refseq:NP_068823.2|refseq:NP_071887.1|refseq:NP_954595.1|refseq:NP_954673.1|refseq:NP_001244322.1|refseq:NP_001244323.1|refseq:NP_001244325.1|ensembl:ENSG00000244687(gene)|ensembl:ENST00000371674(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006282"(regulation of DNA repair)|go:"GO:0006301"(postreplication repair)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0030154"(cell differentiation)|go:"GO:0031371"(ubiquitin conjugating enzyme complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035370"(UBC13-UEV1A complex)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070534"(protein K63-linked ubiquitination)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|rcsb pdb:2A4D|rcsb pdb:2C2V|rcsb pdb:2HLW|rcsb pdb:6D6I|reactome:R-HSA-168638|reactome:R-HSA-168927|reactome:R-HSA-202424|reactome:R-HSA-2871837|reactome:R-HSA-445989|reactome:R-HSA-450302|reactome:R-HSA-450321|reactome:R-HSA-5607764|reactome:R-HSA-9020702|reactome:R-HSA-937039|reactome:R-HSA-937041|reactome:R-HSA-9646399|reactome:R-HSA-975110|reactome:R-HSA-975144|reactome:R-HSA-983168|dip:DIP-41911N	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S3|resulting-ptm:Q8TBN0 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:EwhjYjowkZIAt4UyPcZBUtf9uak10116	rogid:x95N7Dj2KIqu5gySX59xLmfthUg9606	intact-crc:DEB1E4271DD4E351|rigid:2kPXBMFm12TfkLjVnf4Y20dMuRQ	false	sufficient binding region:433-481(IPR013083)	his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q62925	uniprotkb:P22314	intact:EBI-636664	intact:EBI-709688|uniprotkb:Q96E13|uniprotkb:Q5JRR8|ensembl:ENSP00000338413|ensembl:ENSP00000366568	psi-mi:m3k1_rat(display_long)|uniprotkb:MAPK/ERK kinase kinase 1(gene name synonym)|uniprotkb:Map3k1(gene name)|psi-mi:Map3k1(display_short)|uniprotkb:Mekk(gene name synonym)|uniprotkb:Mekk1(gene name synonym)	psi-mi:uba1_human(display_long)|uniprotkb:Ubiquitin-activating enzyme E1(gene name synonym)|uniprotkb:Protein A1S9(gene name synonym)|uniprotkb:UBA1(gene name)|psi-mi:UBA1(display_short)|uniprotkb:A1S9T(gene name synonym)|uniprotkb:UBE1(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9972238|imex:IM-22822-103	author-confidence:Z-score = 11.25	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:620966|refseq:NP_446339.1|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR007527(Zinc finger, SWIM-type)|go:"GO:0000165"(MAPK cascade)|interpro:IPR016024(Armadillo-type fold)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0002011"(morphogenesis of an epithelial sheet)|go:"GO:0003382"(epithelial cell morphogenesis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004706"(JUN kinase kinase kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007254"(JNK cascade)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008432"(JUN kinase binding)|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0016020"(membrane)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0031434"(mitogen-activated protein kinase kinase binding)|go:"GO:0031941"(filamentous actin)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0042060"(wound healing)|go:"GO:0043010"(camera-type eye development)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046625"(sphingolipid binding)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050434"(positive regulation of viral transcription)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0061029"(eyelid development in camera-type eye)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|reactome:R-RNO-166058|reactome:R-RNO-2871796|reactome:R-RNO-975138|reactome:R-RNO-975871|interpro:IPR011989(Armadillo-like helical)|mint:Q62925	refseq:NP_003325.2|refseq:NP_695012.1|refseq:XP_016885269.1|refseq:XP_016885270.1|dip:DIP-33686N|ensembl:ENSG00000130985(gene)|ensembl:ENST00000335972(transcript)|ensembl:ENST00000377351(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0004839"(ubiquitin activating enzyme activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0032446"(protein modification by small protein conjugation)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000011(Ubiquitin-activating enzyme, E1)|interpro:IPR000594(UBA/THIF-type NAD/FAD binding fold)|interpro:IPR018074|interpro:IPR018075|interpro:IPR018965|interpro:IPR019572|interpro:IPR032418|interpro:IPR032420|interpro:IPR033127|interpro:IPR035985|interpro:IPR038252|interpro:IPR042063|interpro:IPR042302|interpro:IPR042449|mint:P22314|rcsb pdb:4P22|rcsb pdb:6DC6|reactome:R-HSA-8866652|reactome:R-HSA-983168	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S3|resulting-ptm:Q8TBN0 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:EwhjYjowkZIAt4UyPcZBUtf9uak10116	rogid:q+vEeA0XLST0Zz173bmEt0dNbDE9606	intact-crc:DEB1E4271DD4E351|rigid:2kPXBMFm12TfkLjVnf4Y20dMuRQ	false	sufficient binding region:433-481(IPR013083)	his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q62925	uniprotkb:P61088	intact:EBI-636664	intact:EBI-1052908|uniprotkb:Q16781|uniprotkb:Q53Y81|ensembl:ENSP00000316176	psi-mi:m3k1_rat(display_long)|uniprotkb:MAPK/ERK kinase kinase 1(gene name synonym)|uniprotkb:Map3k1(gene name)|psi-mi:Map3k1(display_short)|uniprotkb:Mekk(gene name synonym)|uniprotkb:Mekk1(gene name synonym)	psi-mi:ube2n_human(display_long)|uniprotkb:Ubiquitin-protein ligase N(gene name synonym)|uniprotkb:Ubiquitin carrier protein N(gene name synonym)|uniprotkb:Ubc13(gene name synonym)|uniprotkb:Bendless-like ubiquitin-conjugating enzyme(gene name synonym)|uniprotkb:UBE2N(gene name)|psi-mi:UBE2N(display_short)|uniprotkb:BLU(gene name synonym)|uniprotkb:UbcH13(gene name synonym)|uniprotkb:E2 ubiquitin-conjugating enzyme N(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9972238|imex:IM-22822-103	author-confidence:Z-score = 11.25	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:620966|refseq:NP_446339.1|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR007527(Zinc finger, SWIM-type)|go:"GO:0000165"(MAPK cascade)|interpro:IPR016024(Armadillo-type fold)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0002011"(morphogenesis of an epithelial sheet)|go:"GO:0003382"(epithelial cell morphogenesis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004706"(JUN kinase kinase kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007254"(JNK cascade)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008432"(JUN kinase binding)|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0016020"(membrane)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0031434"(mitogen-activated protein kinase kinase binding)|go:"GO:0031941"(filamentous actin)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0042060"(wound healing)|go:"GO:0043010"(camera-type eye development)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046625"(sphingolipid binding)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050434"(positive regulation of viral transcription)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0061029"(eyelid development in camera-type eye)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|reactome:R-RNO-166058|reactome:R-RNO-2871796|reactome:R-RNO-975138|reactome:R-RNO-975871|interpro:IPR011989(Armadillo-like helical)|mint:Q62925	refseq:NP_003339.1|dip:DIP-29829N|ensembl:ENSG00000177889(gene)|ensembl:ENST00000318066(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000729"(DNA double-strand break processing)|go:"GO:0001650"(fibrillar center)|go:"GO:0003723"(RNA binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006282"(regulation of DNA repair)|go:"GO:0006301"(postreplication repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016574"(histone ubiquitination)|go:"GO:0031058"(positive regulation of histone modification)|go:"GO:0031372"(UBC13-MMS2 complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033182"(regulation of histone ubiquitination)|go:"GO:0035370"(UBC13-UEV1A complex)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0061631"(ubiquitin conjugating enzyme activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070534"(protein K63-linked ubiquitination)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|interpro:IPR023313|rcsb pdb:1J7D|rcsb pdb:2C2V|rcsb pdb:3HCT|rcsb pdb:3HCU|rcsb pdb:3VON|rcsb pdb:3W31|rcsb pdb:4DHI|rcsb pdb:4DHJ|rcsb pdb:4DHZ|rcsb pdb:4IP3|rcsb pdb:4NR3|rcsb pdb:4NRG|rcsb pdb:4NRI|rcsb pdb:4ONL|rcsb pdb:4ONM|rcsb pdb:4ONN|rcsb pdb:4ORH|rcsb pdb:4TKP|rcsb pdb:4WHV|rcsb pdb:5AIT|rcsb pdb:5AIU|rcsb pdb:5EYA|rcsb pdb:5H7S|rcsb pdb:5VNZ|rcsb pdb:5VO0|rcsb pdb:5YWR|rcsb pdb:6D6I|rcsb pdb:6JKY|rcsb pdb:6KFP|rcsb pdb:6KG6|rcsb pdb:6KL4|rcsb pdb:6LP2|rcsb pdb:6P5B|rcsb pdb:6S53|reactome:R-HSA-168927|reactome:R-HSA-202424|reactome:R-HSA-2871837|reactome:R-HSA-445989|reactome:R-HSA-450302|reactome:R-HSA-450321|reactome:R-HSA-5607764|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-5696395|reactome:R-HSA-69473|reactome:R-HSA-8866654|reactome:R-HSA-9020702|reactome:R-HSA-937039|reactome:R-HSA-937041|reactome:R-HSA-9646399|reactome:R-HSA-975110|reactome:R-HSA-975144|reactome:R-HSA-983168|rcsb pdb:6ULH|rcsb pdb:6UMP|rcsb pdb:6UMS|rcsb pdb:7BBD|rcsb pdb:7BBF|rcsb pdb:7BXG|reactome:R-HSA-1169408|reactome:R-HSA-168638	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S3|resulting-ptm:Q8TBN0 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:EwhjYjowkZIAt4UyPcZBUtf9uak10116	rogid:dqdszHlq5FLPHC6UWX6uvkC6Yz89606	intact-crc:DEB1E4271DD4E351|rigid:2kPXBMFm12TfkLjVnf4Y20dMuRQ	false	sufficient binding region:433-481(IPR013083)	his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q62925	uniprotkb:Q8TAT6	intact:EBI-636664	intact:EBI-1994109|uniprotkb:Q8N3J1|uniprotkb:Q9H8V2|uniprotkb:Q9H964|uniprotkb:Q9NWR5|uniprotkb:Q9P229|ensembl:ENSP00000331487	psi-mi:m3k1_rat(display_long)|uniprotkb:MAPK/ERK kinase kinase 1(gene name synonym)|uniprotkb:Map3k1(gene name)|psi-mi:Map3k1(display_short)|uniprotkb:Mekk(gene name synonym)|uniprotkb:Mekk1(gene name synonym)	psi-mi:npl4_human(display_long)|uniprotkb:NPLOC4(gene name)|psi-mi:NPLOC4(display_short)|uniprotkb:KIAA1499(gene name synonym)|uniprotkb:NPL4(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9972213|imex:IM-22822-102	author-confidence:Z-score = 10.78	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:620966|refseq:NP_446339.1|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR007527(Zinc finger, SWIM-type)|go:"GO:0000165"(MAPK cascade)|interpro:IPR016024(Armadillo-type fold)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0002011"(morphogenesis of an epithelial sheet)|go:"GO:0003382"(epithelial cell morphogenesis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004706"(JUN kinase kinase kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007254"(JNK cascade)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008432"(JUN kinase binding)|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0016020"(membrane)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0031434"(mitogen-activated protein kinase kinase binding)|go:"GO:0031941"(filamentous actin)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0042060"(wound healing)|go:"GO:0043010"(camera-type eye development)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046625"(sphingolipid binding)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050434"(positive regulation of viral transcription)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0061029"(eyelid development in camera-type eye)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|reactome:R-RNO-166058|reactome:R-RNO-2871796|reactome:R-RNO-975138|reactome:R-RNO-975871|interpro:IPR011989(Armadillo-like helical)|mint:Q62925	refseq:XP_011523281.1|refseq:NP_060391.2|dip:DIP-44059N|ensembl:ENSG00000182446(gene)|ensembl:ENST00000331134(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0007030"(Golgi organization)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030970"(retrograde protein transport, ER to cytosol)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032480"(negative regulation of type I interferon production)|go:"GO:0034098"(VCP-NPL4-UFD1 AAA ATPase complex)|go:"GO:0036501"(UFD1-NPL4 complex)|go:"GO:0039536"(negative regulation of RIG-I signaling pathway)|go:"GO:0042175"(nuclear outer membrane-endoplasmic reticulum membrane network)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0046872"(metal ion binding)|interpro:IPR001876(Zinc finger, RanBP2-type)|interpro:IPR007716(NPL4, zinc-binding putative)|interpro:IPR007717(NPL4)|interpro:IPR016563(Polyubiquitin-tagged protein recognition complex, Npl4 component)|interpro:IPR024682|interpro:IPR029071|interpro:IPR036443|interpro:IPR037518|mint:Q8TAT6|reactome:R-HSA-110320	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S3|resulting-ptm:Q8TAT6 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:EwhjYjowkZIAt4UyPcZBUtf9uak10116	rogid:GXRNmG7yqEf5aFMo7yPDih93yfk9606	intact-crc:3FAECB0ADBDBE3DF|rigid:v7nb1GuaPRnZ6HTUbvMczXw5+i4	false	sufficient binding region:433-481(IPR013083)	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q62925	uniprotkb:Q13404	intact:EBI-636664	intact:EBI-1050671|uniprotkb:Q13403|uniprotkb:Q13532|uniprotkb:Q96H34|uniprotkb:Q9GZT0|uniprotkb:Q9GZW1|uniprotkb:Q9H4J3|uniprotkb:Q9H4J4|uniprotkb:Q9UKL1|uniprotkb:Q9UM48|uniprotkb:Q9UM49|uniprotkb:Q9UM50|uniprotkb:Q5TGE3|uniprotkb:E1P629|uniprotkb:Q5TGE0|ensembl:ENSP00000360739	psi-mi:m3k1_rat(display_long)|uniprotkb:MAPK/ERK kinase kinase 1(gene name synonym)|uniprotkb:Map3k1(gene name)|psi-mi:Map3k1(display_short)|uniprotkb:Mekk(gene name synonym)|uniprotkb:Mekk1(gene name synonym)	psi-mi:ub2v1_human(display_long)|uniprotkb:CROC-1(gene name synonym)|uniprotkb:TRAF6-regulated IKK activator 1 beta Uev1A(gene name synonym)|uniprotkb:P/OKcl.19(orf name)|uniprotkb:UBE2V1(gene name)|psi-mi:UBE2V1(display_short)|uniprotkb:CROC1(gene name synonym)|uniprotkb:UBE2V(gene name synonym)|uniprotkb:UEV1(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9972213|imex:IM-22822-102	author-confidence:Z-score = 10.78	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:620966|refseq:NP_446339.1|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR007527(Zinc finger, SWIM-type)|go:"GO:0000165"(MAPK cascade)|interpro:IPR016024(Armadillo-type fold)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0002011"(morphogenesis of an epithelial sheet)|go:"GO:0003382"(epithelial cell morphogenesis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004706"(JUN kinase kinase kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007254"(JNK cascade)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008432"(JUN kinase binding)|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0016020"(membrane)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0031434"(mitogen-activated protein kinase kinase binding)|go:"GO:0031941"(filamentous actin)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0042060"(wound healing)|go:"GO:0043010"(camera-type eye development)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046625"(sphingolipid binding)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050434"(positive regulation of viral transcription)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0061029"(eyelid development in camera-type eye)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|reactome:R-RNO-166058|reactome:R-RNO-2871796|reactome:R-RNO-975138|reactome:R-RNO-975871|interpro:IPR011989(Armadillo-like helical)|mint:Q62925	refseq:NP_001027459.1|refseq:NP_068823.2|refseq:NP_071887.1|refseq:NP_954595.1|refseq:NP_954673.1|refseq:NP_001244322.1|refseq:NP_001244323.1|refseq:NP_001244325.1|ensembl:ENSG00000244687(gene)|ensembl:ENST00000371674(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006282"(regulation of DNA repair)|go:"GO:0006301"(postreplication repair)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0030154"(cell differentiation)|go:"GO:0031371"(ubiquitin conjugating enzyme complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035370"(UBC13-UEV1A complex)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070534"(protein K63-linked ubiquitination)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|rcsb pdb:2A4D|rcsb pdb:2C2V|rcsb pdb:2HLW|rcsb pdb:6D6I|reactome:R-HSA-168638|reactome:R-HSA-168927|reactome:R-HSA-202424|reactome:R-HSA-2871837|reactome:R-HSA-445989|reactome:R-HSA-450302|reactome:R-HSA-450321|reactome:R-HSA-5607764|reactome:R-HSA-9020702|reactome:R-HSA-937039|reactome:R-HSA-937041|reactome:R-HSA-9646399|reactome:R-HSA-975110|reactome:R-HSA-975144|reactome:R-HSA-983168|dip:DIP-41911N	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S3|resulting-ptm:Q8TAT6 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:EwhjYjowkZIAt4UyPcZBUtf9uak10116	rogid:x95N7Dj2KIqu5gySX59xLmfthUg9606	intact-crc:3FAECB0ADBDBE3DF|rigid:v7nb1GuaPRnZ6HTUbvMczXw5+i4	false	sufficient binding region:433-481(IPR013083)	his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q62925	uniprotkb:P22314	intact:EBI-636664	intact:EBI-709688|uniprotkb:Q96E13|uniprotkb:Q5JRR8|ensembl:ENSP00000338413|ensembl:ENSP00000366568	psi-mi:m3k1_rat(display_long)|uniprotkb:MAPK/ERK kinase kinase 1(gene name synonym)|uniprotkb:Map3k1(gene name)|psi-mi:Map3k1(display_short)|uniprotkb:Mekk(gene name synonym)|uniprotkb:Mekk1(gene name synonym)	psi-mi:uba1_human(display_long)|uniprotkb:Ubiquitin-activating enzyme E1(gene name synonym)|uniprotkb:Protein A1S9(gene name synonym)|uniprotkb:UBA1(gene name)|psi-mi:UBA1(display_short)|uniprotkb:A1S9T(gene name synonym)|uniprotkb:UBE1(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9972213|imex:IM-22822-102	author-confidence:Z-score = 10.78	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:620966|refseq:NP_446339.1|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR007527(Zinc finger, SWIM-type)|go:"GO:0000165"(MAPK cascade)|interpro:IPR016024(Armadillo-type fold)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0002011"(morphogenesis of an epithelial sheet)|go:"GO:0003382"(epithelial cell morphogenesis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004706"(JUN kinase kinase kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007254"(JNK cascade)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008432"(JUN kinase binding)|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0016020"(membrane)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0031434"(mitogen-activated protein kinase kinase binding)|go:"GO:0031941"(filamentous actin)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0042060"(wound healing)|go:"GO:0043010"(camera-type eye development)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046625"(sphingolipid binding)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050434"(positive regulation of viral transcription)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0061029"(eyelid development in camera-type eye)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|reactome:R-RNO-166058|reactome:R-RNO-2871796|reactome:R-RNO-975138|reactome:R-RNO-975871|interpro:IPR011989(Armadillo-like helical)|mint:Q62925	refseq:NP_003325.2|refseq:NP_695012.1|refseq:XP_016885269.1|refseq:XP_016885270.1|dip:DIP-33686N|ensembl:ENSG00000130985(gene)|ensembl:ENST00000335972(transcript)|ensembl:ENST00000377351(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0004839"(ubiquitin activating enzyme activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0032446"(protein modification by small protein conjugation)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000011(Ubiquitin-activating enzyme, E1)|interpro:IPR000594(UBA/THIF-type NAD/FAD binding fold)|interpro:IPR018074|interpro:IPR018075|interpro:IPR018965|interpro:IPR019572|interpro:IPR032418|interpro:IPR032420|interpro:IPR033127|interpro:IPR035985|interpro:IPR038252|interpro:IPR042063|interpro:IPR042302|interpro:IPR042449|mint:P22314|rcsb pdb:4P22|rcsb pdb:6DC6|reactome:R-HSA-8866652|reactome:R-HSA-983168	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S3|resulting-ptm:Q8TAT6 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:EwhjYjowkZIAt4UyPcZBUtf9uak10116	rogid:q+vEeA0XLST0Zz173bmEt0dNbDE9606	intact-crc:3FAECB0ADBDBE3DF|rigid:v7nb1GuaPRnZ6HTUbvMczXw5+i4	false	sufficient binding region:433-481(IPR013083)	his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q62925	uniprotkb:P61088	intact:EBI-636664	intact:EBI-1052908|uniprotkb:Q16781|uniprotkb:Q53Y81|ensembl:ENSP00000316176	psi-mi:m3k1_rat(display_long)|uniprotkb:MAPK/ERK kinase kinase 1(gene name synonym)|uniprotkb:Map3k1(gene name)|psi-mi:Map3k1(display_short)|uniprotkb:Mekk(gene name synonym)|uniprotkb:Mekk1(gene name synonym)	psi-mi:ube2n_human(display_long)|uniprotkb:Ubiquitin-protein ligase N(gene name synonym)|uniprotkb:Ubiquitin carrier protein N(gene name synonym)|uniprotkb:Ubc13(gene name synonym)|uniprotkb:Bendless-like ubiquitin-conjugating enzyme(gene name synonym)|uniprotkb:UBE2N(gene name)|psi-mi:UBE2N(display_short)|uniprotkb:BLU(gene name synonym)|uniprotkb:UbcH13(gene name synonym)|uniprotkb:E2 ubiquitin-conjugating enzyme N(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9972213|imex:IM-22822-102	author-confidence:Z-score = 10.78	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:620966|refseq:NP_446339.1|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR007527(Zinc finger, SWIM-type)|go:"GO:0000165"(MAPK cascade)|interpro:IPR016024(Armadillo-type fold)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0002011"(morphogenesis of an epithelial sheet)|go:"GO:0003382"(epithelial cell morphogenesis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004706"(JUN kinase kinase kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007254"(JNK cascade)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008432"(JUN kinase binding)|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0016020"(membrane)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0031434"(mitogen-activated protein kinase kinase binding)|go:"GO:0031941"(filamentous actin)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0042060"(wound healing)|go:"GO:0043010"(camera-type eye development)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046625"(sphingolipid binding)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050434"(positive regulation of viral transcription)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0061029"(eyelid development in camera-type eye)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|reactome:R-RNO-166058|reactome:R-RNO-2871796|reactome:R-RNO-975138|reactome:R-RNO-975871|interpro:IPR011989(Armadillo-like helical)|mint:Q62925	refseq:NP_003339.1|dip:DIP-29829N|ensembl:ENSG00000177889(gene)|ensembl:ENST00000318066(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000729"(DNA double-strand break processing)|go:"GO:0001650"(fibrillar center)|go:"GO:0003723"(RNA binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006282"(regulation of DNA repair)|go:"GO:0006301"(postreplication repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016574"(histone ubiquitination)|go:"GO:0031058"(positive regulation of histone modification)|go:"GO:0031372"(UBC13-MMS2 complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033182"(regulation of histone ubiquitination)|go:"GO:0035370"(UBC13-UEV1A complex)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0061631"(ubiquitin conjugating enzyme activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070534"(protein K63-linked ubiquitination)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|interpro:IPR023313|rcsb pdb:1J7D|rcsb pdb:2C2V|rcsb pdb:3HCT|rcsb pdb:3HCU|rcsb pdb:3VON|rcsb pdb:3W31|rcsb pdb:4DHI|rcsb pdb:4DHJ|rcsb pdb:4DHZ|rcsb pdb:4IP3|rcsb pdb:4NR3|rcsb pdb:4NRG|rcsb pdb:4NRI|rcsb pdb:4ONL|rcsb pdb:4ONM|rcsb pdb:4ONN|rcsb pdb:4ORH|rcsb pdb:4TKP|rcsb pdb:4WHV|rcsb pdb:5AIT|rcsb pdb:5AIU|rcsb pdb:5EYA|rcsb pdb:5H7S|rcsb pdb:5VNZ|rcsb pdb:5VO0|rcsb pdb:5YWR|rcsb pdb:6D6I|rcsb pdb:6JKY|rcsb pdb:6KFP|rcsb pdb:6KG6|rcsb pdb:6KL4|rcsb pdb:6LP2|rcsb pdb:6P5B|rcsb pdb:6S53|reactome:R-HSA-168927|reactome:R-HSA-202424|reactome:R-HSA-2871837|reactome:R-HSA-445989|reactome:R-HSA-450302|reactome:R-HSA-450321|reactome:R-HSA-5607764|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-5696395|reactome:R-HSA-69473|reactome:R-HSA-8866654|reactome:R-HSA-9020702|reactome:R-HSA-937039|reactome:R-HSA-937041|reactome:R-HSA-9646399|reactome:R-HSA-975110|reactome:R-HSA-975144|reactome:R-HSA-983168|rcsb pdb:6ULH|rcsb pdb:6UMP|rcsb pdb:6UMS|rcsb pdb:7BBD|rcsb pdb:7BBF|rcsb pdb:7BXG|reactome:R-HSA-1169408|reactome:R-HSA-168638	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S3|resulting-ptm:Q8TAT6 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:EwhjYjowkZIAt4UyPcZBUtf9uak10116	rogid:dqdszHlq5FLPHC6UWX6uvkC6Yz89606	intact-crc:3FAECB0ADBDBE3DF|rigid:v7nb1GuaPRnZ6HTUbvMczXw5+i4	false	sufficient binding region:433-481(IPR013083)	his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q62925	uniprotkb:Q13404	intact:EBI-636664	intact:EBI-1050671|uniprotkb:Q13403|uniprotkb:Q13532|uniprotkb:Q96H34|uniprotkb:Q9GZT0|uniprotkb:Q9GZW1|uniprotkb:Q9H4J3|uniprotkb:Q9H4J4|uniprotkb:Q9UKL1|uniprotkb:Q9UM48|uniprotkb:Q9UM49|uniprotkb:Q9UM50|uniprotkb:Q5TGE3|uniprotkb:E1P629|uniprotkb:Q5TGE0|ensembl:ENSP00000360739	psi-mi:m3k1_rat(display_long)|uniprotkb:MAPK/ERK kinase kinase 1(gene name synonym)|uniprotkb:Map3k1(gene name)|psi-mi:Map3k1(display_short)|uniprotkb:Mekk(gene name synonym)|uniprotkb:Mekk1(gene name synonym)	psi-mi:ub2v1_human(display_long)|uniprotkb:CROC-1(gene name synonym)|uniprotkb:TRAF6-regulated IKK activator 1 beta Uev1A(gene name synonym)|uniprotkb:P/OKcl.19(orf name)|uniprotkb:UBE2V1(gene name)|psi-mi:UBE2V1(display_short)|uniprotkb:CROC1(gene name synonym)|uniprotkb:UBE2V(gene name synonym)|uniprotkb:UEV1(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9972288|imex:IM-22822-105	author-confidence:Z-score = 11.20	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:620966|refseq:NP_446339.1|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR007527(Zinc finger, SWIM-type)|go:"GO:0000165"(MAPK cascade)|interpro:IPR016024(Armadillo-type fold)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0002011"(morphogenesis of an epithelial sheet)|go:"GO:0003382"(epithelial cell morphogenesis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004706"(JUN kinase kinase kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007254"(JNK cascade)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008432"(JUN kinase binding)|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0016020"(membrane)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0031434"(mitogen-activated protein kinase kinase binding)|go:"GO:0031941"(filamentous actin)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0042060"(wound healing)|go:"GO:0043010"(camera-type eye development)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046625"(sphingolipid binding)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050434"(positive regulation of viral transcription)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0061029"(eyelid development in camera-type eye)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|reactome:R-RNO-166058|reactome:R-RNO-2871796|reactome:R-RNO-975138|reactome:R-RNO-975871|interpro:IPR011989(Armadillo-like helical)|mint:Q62925	refseq:NP_001027459.1|refseq:NP_068823.2|refseq:NP_071887.1|refseq:NP_954595.1|refseq:NP_954673.1|refseq:NP_001244322.1|refseq:NP_001244323.1|refseq:NP_001244325.1|ensembl:ENSG00000244687(gene)|ensembl:ENST00000371674(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006282"(regulation of DNA repair)|go:"GO:0006301"(postreplication repair)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0030154"(cell differentiation)|go:"GO:0031371"(ubiquitin conjugating enzyme complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035370"(UBC13-UEV1A complex)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070534"(protein K63-linked ubiquitination)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|rcsb pdb:2A4D|rcsb pdb:2C2V|rcsb pdb:2HLW|rcsb pdb:6D6I|reactome:R-HSA-168638|reactome:R-HSA-168927|reactome:R-HSA-202424|reactome:R-HSA-2871837|reactome:R-HSA-445989|reactome:R-HSA-450302|reactome:R-HSA-450321|reactome:R-HSA-5607764|reactome:R-HSA-9020702|reactome:R-HSA-937039|reactome:R-HSA-937041|reactome:R-HSA-9646399|reactome:R-HSA-975110|reactome:R-HSA-975144|reactome:R-HSA-983168|dip:DIP-41911N	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S3|resulting-ptm:Q8TF42 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:EwhjYjowkZIAt4UyPcZBUtf9uak10116	rogid:x95N7Dj2KIqu5gySX59xLmfthUg9606	intact-crc:2396066858F225E7|rigid:mbz6AXkbbybQ1FuCXqvPDy62U9c	false	sufficient binding region:433-481(IPR013083)	his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q62925	uniprotkb:P22314	intact:EBI-636664	intact:EBI-709688|uniprotkb:Q96E13|uniprotkb:Q5JRR8|ensembl:ENSP00000338413|ensembl:ENSP00000366568	psi-mi:m3k1_rat(display_long)|uniprotkb:MAPK/ERK kinase kinase 1(gene name synonym)|uniprotkb:Map3k1(gene name)|psi-mi:Map3k1(display_short)|uniprotkb:Mekk(gene name synonym)|uniprotkb:Mekk1(gene name synonym)	psi-mi:uba1_human(display_long)|uniprotkb:Ubiquitin-activating enzyme E1(gene name synonym)|uniprotkb:Protein A1S9(gene name synonym)|uniprotkb:UBA1(gene name)|psi-mi:UBA1(display_short)|uniprotkb:A1S9T(gene name synonym)|uniprotkb:UBE1(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9972288|imex:IM-22822-105	author-confidence:Z-score = 11.20	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:620966|refseq:NP_446339.1|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR007527(Zinc finger, SWIM-type)|go:"GO:0000165"(MAPK cascade)|interpro:IPR016024(Armadillo-type fold)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0002011"(morphogenesis of an epithelial sheet)|go:"GO:0003382"(epithelial cell morphogenesis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004706"(JUN kinase kinase kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007254"(JNK cascade)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008432"(JUN kinase binding)|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0016020"(membrane)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0031434"(mitogen-activated protein kinase kinase binding)|go:"GO:0031941"(filamentous actin)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0042060"(wound healing)|go:"GO:0043010"(camera-type eye development)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046625"(sphingolipid binding)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050434"(positive regulation of viral transcription)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0061029"(eyelid development in camera-type eye)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|reactome:R-RNO-166058|reactome:R-RNO-2871796|reactome:R-RNO-975138|reactome:R-RNO-975871|interpro:IPR011989(Armadillo-like helical)|mint:Q62925	refseq:NP_003325.2|refseq:NP_695012.1|refseq:XP_016885269.1|refseq:XP_016885270.1|dip:DIP-33686N|ensembl:ENSG00000130985(gene)|ensembl:ENST00000335972(transcript)|ensembl:ENST00000377351(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0004839"(ubiquitin activating enzyme activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0032446"(protein modification by small protein conjugation)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000011(Ubiquitin-activating enzyme, E1)|interpro:IPR000594(UBA/THIF-type NAD/FAD binding fold)|interpro:IPR018074|interpro:IPR018075|interpro:IPR018965|interpro:IPR019572|interpro:IPR032418|interpro:IPR032420|interpro:IPR033127|interpro:IPR035985|interpro:IPR038252|interpro:IPR042063|interpro:IPR042302|interpro:IPR042449|mint:P22314|rcsb pdb:4P22|rcsb pdb:6DC6|reactome:R-HSA-8866652|reactome:R-HSA-983168	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S3|resulting-ptm:Q8TF42 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:EwhjYjowkZIAt4UyPcZBUtf9uak10116	rogid:q+vEeA0XLST0Zz173bmEt0dNbDE9606	intact-crc:2396066858F225E7|rigid:mbz6AXkbbybQ1FuCXqvPDy62U9c	false	sufficient binding region:433-481(IPR013083)	his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q62925	uniprotkb:P61088	intact:EBI-636664	intact:EBI-1052908|uniprotkb:Q16781|uniprotkb:Q53Y81|ensembl:ENSP00000316176	psi-mi:m3k1_rat(display_long)|uniprotkb:MAPK/ERK kinase kinase 1(gene name synonym)|uniprotkb:Map3k1(gene name)|psi-mi:Map3k1(display_short)|uniprotkb:Mekk(gene name synonym)|uniprotkb:Mekk1(gene name synonym)	psi-mi:ube2n_human(display_long)|uniprotkb:Ubiquitin-protein ligase N(gene name synonym)|uniprotkb:Ubiquitin carrier protein N(gene name synonym)|uniprotkb:Ubc13(gene name synonym)|uniprotkb:Bendless-like ubiquitin-conjugating enzyme(gene name synonym)|uniprotkb:UBE2N(gene name)|psi-mi:UBE2N(display_short)|uniprotkb:BLU(gene name synonym)|uniprotkb:UbcH13(gene name synonym)|uniprotkb:E2 ubiquitin-conjugating enzyme N(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9972288|imex:IM-22822-105	author-confidence:Z-score = 11.20	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:620966|refseq:NP_446339.1|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR007527(Zinc finger, SWIM-type)|go:"GO:0000165"(MAPK cascade)|interpro:IPR016024(Armadillo-type fold)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0002011"(morphogenesis of an epithelial sheet)|go:"GO:0003382"(epithelial cell morphogenesis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004706"(JUN kinase kinase kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007254"(JNK cascade)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008432"(JUN kinase binding)|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0016020"(membrane)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0031434"(mitogen-activated protein kinase kinase binding)|go:"GO:0031941"(filamentous actin)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0042060"(wound healing)|go:"GO:0043010"(camera-type eye development)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046625"(sphingolipid binding)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050434"(positive regulation of viral transcription)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0061029"(eyelid development in camera-type eye)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|reactome:R-RNO-166058|reactome:R-RNO-2871796|reactome:R-RNO-975138|reactome:R-RNO-975871|interpro:IPR011989(Armadillo-like helical)|mint:Q62925	refseq:NP_003339.1|dip:DIP-29829N|ensembl:ENSG00000177889(gene)|ensembl:ENST00000318066(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000729"(DNA double-strand break processing)|go:"GO:0001650"(fibrillar center)|go:"GO:0003723"(RNA binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006282"(regulation of DNA repair)|go:"GO:0006301"(postreplication repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016574"(histone ubiquitination)|go:"GO:0031058"(positive regulation of histone modification)|go:"GO:0031372"(UBC13-MMS2 complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033182"(regulation of histone ubiquitination)|go:"GO:0035370"(UBC13-UEV1A complex)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0061631"(ubiquitin conjugating enzyme activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070534"(protein K63-linked ubiquitination)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|interpro:IPR023313|rcsb pdb:1J7D|rcsb pdb:2C2V|rcsb pdb:3HCT|rcsb pdb:3HCU|rcsb pdb:3VON|rcsb pdb:3W31|rcsb pdb:4DHI|rcsb pdb:4DHJ|rcsb pdb:4DHZ|rcsb pdb:4IP3|rcsb pdb:4NR3|rcsb pdb:4NRG|rcsb pdb:4NRI|rcsb pdb:4ONL|rcsb pdb:4ONM|rcsb pdb:4ONN|rcsb pdb:4ORH|rcsb pdb:4TKP|rcsb pdb:4WHV|rcsb pdb:5AIT|rcsb pdb:5AIU|rcsb pdb:5EYA|rcsb pdb:5H7S|rcsb pdb:5VNZ|rcsb pdb:5VO0|rcsb pdb:5YWR|rcsb pdb:6D6I|rcsb pdb:6JKY|rcsb pdb:6KFP|rcsb pdb:6KG6|rcsb pdb:6KL4|rcsb pdb:6LP2|rcsb pdb:6P5B|rcsb pdb:6S53|reactome:R-HSA-168927|reactome:R-HSA-202424|reactome:R-HSA-2871837|reactome:R-HSA-445989|reactome:R-HSA-450302|reactome:R-HSA-450321|reactome:R-HSA-5607764|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-5696395|reactome:R-HSA-69473|reactome:R-HSA-8866654|reactome:R-HSA-9020702|reactome:R-HSA-937039|reactome:R-HSA-937041|reactome:R-HSA-9646399|reactome:R-HSA-975110|reactome:R-HSA-975144|reactome:R-HSA-983168|rcsb pdb:6ULH|rcsb pdb:6UMP|rcsb pdb:6UMS|rcsb pdb:7BBD|rcsb pdb:7BBF|rcsb pdb:7BXG|reactome:R-HSA-1169408|reactome:R-HSA-168638	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S3|resulting-ptm:Q8TF42 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:EwhjYjowkZIAt4UyPcZBUtf9uak10116	rogid:dqdszHlq5FLPHC6UWX6uvkC6Yz89606	intact-crc:2396066858F225E7|rigid:mbz6AXkbbybQ1FuCXqvPDy62U9c	false	sufficient binding region:433-481(IPR013083)	his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q62925	uniprotkb:Q8TF42	intact:EBI-636664	intact:EBI-1380492|uniprotkb:Q53GT5|uniprotkb:Q53GT8|uniprotkb:Q8NBV7|uniprotkb:Q96IG9|uniprotkb:Q96NZ2|ensembl:ENSP00000284273	psi-mi:m3k1_rat(display_long)|uniprotkb:MAPK/ERK kinase kinase 1(gene name synonym)|uniprotkb:Map3k1(gene name)|psi-mi:Map3k1(display_short)|uniprotkb:Mekk(gene name synonym)|uniprotkb:Mekk1(gene name synonym)	psi-mi:ubs3b_human(display_long)|uniprotkb:UBASH3B(gene name)|psi-mi:UBASH3B(display_short)|uniprotkb:KIAA1959(gene name synonym)|uniprotkb:STS1(gene name synonym)|uniprotkb:Suppressor of T-cell receptor signaling 1(gene name synonym)|uniprotkb:Cbl-interacting protein p70(gene name synonym)|uniprotkb:T-cell ubiquitin ligand 2(gene name synonym)|uniprotkb:Tyrosine-protein phosphatase STS1/TULA2(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9972288|imex:IM-22822-105	author-confidence:Z-score = 11.20	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:620966|refseq:NP_446339.1|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR007527(Zinc finger, SWIM-type)|go:"GO:0000165"(MAPK cascade)|interpro:IPR016024(Armadillo-type fold)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0002011"(morphogenesis of an epithelial sheet)|go:"GO:0003382"(epithelial cell morphogenesis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004706"(JUN kinase kinase kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007254"(JNK cascade)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008432"(JUN kinase binding)|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0016020"(membrane)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0031434"(mitogen-activated protein kinase kinase binding)|go:"GO:0031941"(filamentous actin)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0042060"(wound healing)|go:"GO:0043010"(camera-type eye development)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046625"(sphingolipid binding)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050434"(positive regulation of viral transcription)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0061029"(eyelid development in camera-type eye)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|reactome:R-RNO-166058|reactome:R-RNO-2871796|reactome:R-RNO-975138|reactome:R-RNO-975871|interpro:IPR011989(Armadillo-like helical)|mint:Q62925	refseq:NP_116262.2|ensembl:ENSG00000154127(gene)|ensembl:ENST00000284273(transcript)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0009968"(negative regulation of signal transduction)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0035335"(peptidyl-tyrosine dephosphorylation)|go:"GO:0038063"(collagen-activated tyrosine kinase receptor signaling pathway)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0045670"(regulation of osteoclast differentiation)|go:"GO:0045671"(negative regulation of osteoclast differentiation)|go:"GO:0045779"(negative regulation of bone resorption)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051279"(regulation of release of sequestered calcium ion into cytosol)|go:"GO:0070527"(platelet aggregation)|go:"GO:0090331"(negative regulation of platelet aggregation)|interpro:IPR001452(Src homology-3)|interpro:IPR009060(UBA-like)|interpro:IPR013078(Phosphoglycerate mutase)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR029033|interpro:IPR035632|interpro:IPR036028|mint:Q8TF42|rcsb pdb:2CPW|rcsb pdb:2E5K|rcsb pdb:5VR6|rcsb pdb:5W5G|go:"GO:0042802"(identical protein binding)	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S3|resulting-ptm:Q8TF42 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:EwhjYjowkZIAt4UyPcZBUtf9uak10116	rogid:rInBY4dNsLDJJPjZQqMSkuKJwns9606	intact-crc:2396066858F225E7|rigid:mbz6AXkbbybQ1FuCXqvPDy62U9c	false	sufficient binding region:433-481(IPR013083)	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q62925	uniprotkb:Q8TEB9	intact:EBI-636664	intact:EBI-9916444|uniprotkb:Q8IV60|uniprotkb:Q53S43|uniprotkb:Q5EBM8|uniprotkb:Q495B9|uniprotkb:Q6P5V8|uniprotkb:Q9H057|ensembl:ENSP00000344779|ensembl:ENSP00000375914|intact:EBI-28982195	psi-mi:m3k1_rat(display_long)|uniprotkb:MAPK/ERK kinase kinase 1(gene name synonym)|uniprotkb:Map3k1(gene name)|psi-mi:Map3k1(display_short)|uniprotkb:Mekk(gene name synonym)|uniprotkb:Mekk1(gene name synonym)	psi-mi:rhbl4_human(display_long)|uniprotkb:RHBDL4(gene name synonym)|uniprotkb:Rhomboid domain-containing protein 1(gene name synonym)|uniprotkb:Rhomboid-like protein 4(gene name synonym)|uniprotkb:HSD-50(orf name)|uniprotkb:HSD50(orf name)|uniprotkb:RHBDD1(gene name)|psi-mi:RHBDD1(display_short)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9972263|imex:IM-22822-104	author-confidence:Z-score = 10.77	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:620966|refseq:NP_446339.1|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR007527(Zinc finger, SWIM-type)|go:"GO:0000165"(MAPK cascade)|interpro:IPR016024(Armadillo-type fold)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0002011"(morphogenesis of an epithelial sheet)|go:"GO:0003382"(epithelial cell morphogenesis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004706"(JUN kinase kinase kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007254"(JNK cascade)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008432"(JUN kinase binding)|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0016020"(membrane)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0031434"(mitogen-activated protein kinase kinase binding)|go:"GO:0031941"(filamentous actin)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0042060"(wound healing)|go:"GO:0043010"(camera-type eye development)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046625"(sphingolipid binding)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050434"(positive regulation of viral transcription)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0061029"(eyelid development in camera-type eye)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|reactome:R-RNO-166058|reactome:R-RNO-2871796|reactome:R-RNO-975138|reactome:R-RNO-975871|interpro:IPR011989(Armadillo-like helical)|mint:Q62925	ensembl:ENSP00000344779|ensembl:ENSP00000375914|refseq:NP_001161080.1|refseq:NP_115652.2|refseq:XP_016860572.1|refseq:XP_016860573.1|refseq:XP_016860574.1|refseq:XP_016860575.1|refseq:XP_016860576.1|refseq:XP_016860577.1|refseq:XP_016860578.1|refseq:XP_016860579.1|refseq:XP_016860580.1|refseq:XP_016860581.1|ensembl:ENSG00000144468(gene)|ensembl:ENST00000341329(transcript)|ensembl:ENST00000392062(transcript)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0010954"(positive regulation of protein processing)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0031293"(membrane protein intracellular domain proteolysis)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0033619"(membrane protein proteolysis)|go:"GO:0034620"(cellular response to unfolded protein)|go:"GO:0034644"(cellular response to UV)|go:"GO:0036503"(ERAD pathway)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043687"(post-translational protein modification)|go:"GO:0044322"(endoplasmic reticulum quality control compartment)|go:"GO:0048515"(spermatid differentiation)|go:"GO:0051047"(positive regulation of secretion)|go:"GO:1904211"(membrane protein proteolysis involved in retrograde protein transport, ER to cytosol)|interpro:IPR022764|interpro:IPR035952|rcsb pdb:5EPP|go:"GO:0045732"(positive regulation of protein catabolic process)	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S3|resulting-ptm:Q8TEB9 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:EwhjYjowkZIAt4UyPcZBUtf9uak10116	rogid:SlP71PmrPHFnC5EcRuzD9NjO7/09606	intact-crc:8574CFA998BFD312|rigid:L8KFsd2fn1mXEkVroumuztYq8rA	false	sufficient binding region:433-481(IPR013083)	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q62925	uniprotkb:Q13404	intact:EBI-636664	intact:EBI-1050671|uniprotkb:Q13403|uniprotkb:Q13532|uniprotkb:Q96H34|uniprotkb:Q9GZT0|uniprotkb:Q9GZW1|uniprotkb:Q9H4J3|uniprotkb:Q9H4J4|uniprotkb:Q9UKL1|uniprotkb:Q9UM48|uniprotkb:Q9UM49|uniprotkb:Q9UM50|uniprotkb:Q5TGE3|uniprotkb:E1P629|uniprotkb:Q5TGE0|ensembl:ENSP00000360739	psi-mi:m3k1_rat(display_long)|uniprotkb:MAPK/ERK kinase kinase 1(gene name synonym)|uniprotkb:Map3k1(gene name)|psi-mi:Map3k1(display_short)|uniprotkb:Mekk(gene name synonym)|uniprotkb:Mekk1(gene name synonym)	psi-mi:ub2v1_human(display_long)|uniprotkb:CROC-1(gene name synonym)|uniprotkb:TRAF6-regulated IKK activator 1 beta Uev1A(gene name synonym)|uniprotkb:P/OKcl.19(orf name)|uniprotkb:UBE2V1(gene name)|psi-mi:UBE2V1(display_short)|uniprotkb:CROC1(gene name synonym)|uniprotkb:UBE2V(gene name synonym)|uniprotkb:UEV1(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9972263|imex:IM-22822-104	author-confidence:Z-score = 10.77	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:620966|refseq:NP_446339.1|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR007527(Zinc finger, SWIM-type)|go:"GO:0000165"(MAPK cascade)|interpro:IPR016024(Armadillo-type fold)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0002011"(morphogenesis of an epithelial sheet)|go:"GO:0003382"(epithelial cell morphogenesis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004706"(JUN kinase kinase kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007254"(JNK cascade)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008432"(JUN kinase binding)|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0016020"(membrane)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0031434"(mitogen-activated protein kinase kinase binding)|go:"GO:0031941"(filamentous actin)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0042060"(wound healing)|go:"GO:0043010"(camera-type eye development)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046625"(sphingolipid binding)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050434"(positive regulation of viral transcription)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0061029"(eyelid development in camera-type eye)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|reactome:R-RNO-166058|reactome:R-RNO-2871796|reactome:R-RNO-975138|reactome:R-RNO-975871|interpro:IPR011989(Armadillo-like helical)|mint:Q62925	refseq:NP_001027459.1|refseq:NP_068823.2|refseq:NP_071887.1|refseq:NP_954595.1|refseq:NP_954673.1|refseq:NP_001244322.1|refseq:NP_001244323.1|refseq:NP_001244325.1|ensembl:ENSG00000244687(gene)|ensembl:ENST00000371674(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006282"(regulation of DNA repair)|go:"GO:0006301"(postreplication repair)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0030154"(cell differentiation)|go:"GO:0031371"(ubiquitin conjugating enzyme complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035370"(UBC13-UEV1A complex)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070534"(protein K63-linked ubiquitination)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|rcsb pdb:2A4D|rcsb pdb:2C2V|rcsb pdb:2HLW|rcsb pdb:6D6I|reactome:R-HSA-168638|reactome:R-HSA-168927|reactome:R-HSA-202424|reactome:R-HSA-2871837|reactome:R-HSA-445989|reactome:R-HSA-450302|reactome:R-HSA-450321|reactome:R-HSA-5607764|reactome:R-HSA-9020702|reactome:R-HSA-937039|reactome:R-HSA-937041|reactome:R-HSA-9646399|reactome:R-HSA-975110|reactome:R-HSA-975144|reactome:R-HSA-983168|dip:DIP-41911N	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S3|resulting-ptm:Q8TEB9 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:EwhjYjowkZIAt4UyPcZBUtf9uak10116	rogid:x95N7Dj2KIqu5gySX59xLmfthUg9606	intact-crc:8574CFA998BFD312|rigid:L8KFsd2fn1mXEkVroumuztYq8rA	false	sufficient binding region:433-481(IPR013083)	his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q62925	uniprotkb:P22314	intact:EBI-636664	intact:EBI-709688|uniprotkb:Q96E13|uniprotkb:Q5JRR8|ensembl:ENSP00000338413|ensembl:ENSP00000366568	psi-mi:m3k1_rat(display_long)|uniprotkb:MAPK/ERK kinase kinase 1(gene name synonym)|uniprotkb:Map3k1(gene name)|psi-mi:Map3k1(display_short)|uniprotkb:Mekk(gene name synonym)|uniprotkb:Mekk1(gene name synonym)	psi-mi:uba1_human(display_long)|uniprotkb:Ubiquitin-activating enzyme E1(gene name synonym)|uniprotkb:Protein A1S9(gene name synonym)|uniprotkb:UBA1(gene name)|psi-mi:UBA1(display_short)|uniprotkb:A1S9T(gene name synonym)|uniprotkb:UBE1(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9972263|imex:IM-22822-104	author-confidence:Z-score = 10.77	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:620966|refseq:NP_446339.1|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR007527(Zinc finger, SWIM-type)|go:"GO:0000165"(MAPK cascade)|interpro:IPR016024(Armadillo-type fold)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0002011"(morphogenesis of an epithelial sheet)|go:"GO:0003382"(epithelial cell morphogenesis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004706"(JUN kinase kinase kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007254"(JNK cascade)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008432"(JUN kinase binding)|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0016020"(membrane)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0031434"(mitogen-activated protein kinase kinase binding)|go:"GO:0031941"(filamentous actin)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0042060"(wound healing)|go:"GO:0043010"(camera-type eye development)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046625"(sphingolipid binding)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050434"(positive regulation of viral transcription)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0061029"(eyelid development in camera-type eye)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|reactome:R-RNO-166058|reactome:R-RNO-2871796|reactome:R-RNO-975138|reactome:R-RNO-975871|interpro:IPR011989(Armadillo-like helical)|mint:Q62925	refseq:NP_003325.2|refseq:NP_695012.1|refseq:XP_016885269.1|refseq:XP_016885270.1|dip:DIP-33686N|ensembl:ENSG00000130985(gene)|ensembl:ENST00000335972(transcript)|ensembl:ENST00000377351(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0004839"(ubiquitin activating enzyme activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0032446"(protein modification by small protein conjugation)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000011(Ubiquitin-activating enzyme, E1)|interpro:IPR000594(UBA/THIF-type NAD/FAD binding fold)|interpro:IPR018074|interpro:IPR018075|interpro:IPR018965|interpro:IPR019572|interpro:IPR032418|interpro:IPR032420|interpro:IPR033127|interpro:IPR035985|interpro:IPR038252|interpro:IPR042063|interpro:IPR042302|interpro:IPR042449|mint:P22314|rcsb pdb:4P22|rcsb pdb:6DC6|reactome:R-HSA-8866652|reactome:R-HSA-983168	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S3|resulting-ptm:Q8TEB9 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:EwhjYjowkZIAt4UyPcZBUtf9uak10116	rogid:q+vEeA0XLST0Zz173bmEt0dNbDE9606	intact-crc:8574CFA998BFD312|rigid:L8KFsd2fn1mXEkVroumuztYq8rA	false	sufficient binding region:433-481(IPR013083)	his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q62925	uniprotkb:P61088	intact:EBI-636664	intact:EBI-1052908|uniprotkb:Q16781|uniprotkb:Q53Y81|ensembl:ENSP00000316176	psi-mi:m3k1_rat(display_long)|uniprotkb:MAPK/ERK kinase kinase 1(gene name synonym)|uniprotkb:Map3k1(gene name)|psi-mi:Map3k1(display_short)|uniprotkb:Mekk(gene name synonym)|uniprotkb:Mekk1(gene name synonym)	psi-mi:ube2n_human(display_long)|uniprotkb:Ubiquitin-protein ligase N(gene name synonym)|uniprotkb:Ubiquitin carrier protein N(gene name synonym)|uniprotkb:Ubc13(gene name synonym)|uniprotkb:Bendless-like ubiquitin-conjugating enzyme(gene name synonym)|uniprotkb:UBE2N(gene name)|psi-mi:UBE2N(display_short)|uniprotkb:BLU(gene name synonym)|uniprotkb:UbcH13(gene name synonym)|uniprotkb:E2 ubiquitin-conjugating enzyme N(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9972263|imex:IM-22822-104	author-confidence:Z-score = 10.77	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:620966|refseq:NP_446339.1|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR007527(Zinc finger, SWIM-type)|go:"GO:0000165"(MAPK cascade)|interpro:IPR016024(Armadillo-type fold)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0002011"(morphogenesis of an epithelial sheet)|go:"GO:0003382"(epithelial cell morphogenesis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004706"(JUN kinase kinase kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007254"(JNK cascade)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008432"(JUN kinase binding)|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0016020"(membrane)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0031434"(mitogen-activated protein kinase kinase binding)|go:"GO:0031941"(filamentous actin)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0042060"(wound healing)|go:"GO:0043010"(camera-type eye development)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046625"(sphingolipid binding)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050434"(positive regulation of viral transcription)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0061029"(eyelid development in camera-type eye)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|reactome:R-RNO-166058|reactome:R-RNO-2871796|reactome:R-RNO-975138|reactome:R-RNO-975871|interpro:IPR011989(Armadillo-like helical)|mint:Q62925	refseq:NP_003339.1|dip:DIP-29829N|ensembl:ENSG00000177889(gene)|ensembl:ENST00000318066(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000729"(DNA double-strand break processing)|go:"GO:0001650"(fibrillar center)|go:"GO:0003723"(RNA binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006282"(regulation of DNA repair)|go:"GO:0006301"(postreplication repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016574"(histone ubiquitination)|go:"GO:0031058"(positive regulation of histone modification)|go:"GO:0031372"(UBC13-MMS2 complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033182"(regulation of histone ubiquitination)|go:"GO:0035370"(UBC13-UEV1A complex)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0061631"(ubiquitin conjugating enzyme activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070534"(protein K63-linked ubiquitination)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|interpro:IPR023313|rcsb pdb:1J7D|rcsb pdb:2C2V|rcsb pdb:3HCT|rcsb pdb:3HCU|rcsb pdb:3VON|rcsb pdb:3W31|rcsb pdb:4DHI|rcsb pdb:4DHJ|rcsb pdb:4DHZ|rcsb pdb:4IP3|rcsb pdb:4NR3|rcsb pdb:4NRG|rcsb pdb:4NRI|rcsb pdb:4ONL|rcsb pdb:4ONM|rcsb pdb:4ONN|rcsb pdb:4ORH|rcsb pdb:4TKP|rcsb pdb:4WHV|rcsb pdb:5AIT|rcsb pdb:5AIU|rcsb pdb:5EYA|rcsb pdb:5H7S|rcsb pdb:5VNZ|rcsb pdb:5VO0|rcsb pdb:5YWR|rcsb pdb:6D6I|rcsb pdb:6JKY|rcsb pdb:6KFP|rcsb pdb:6KG6|rcsb pdb:6KL4|rcsb pdb:6LP2|rcsb pdb:6P5B|rcsb pdb:6S53|reactome:R-HSA-168927|reactome:R-HSA-202424|reactome:R-HSA-2871837|reactome:R-HSA-445989|reactome:R-HSA-450302|reactome:R-HSA-450321|reactome:R-HSA-5607764|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-5696395|reactome:R-HSA-69473|reactome:R-HSA-8866654|reactome:R-HSA-9020702|reactome:R-HSA-937039|reactome:R-HSA-937041|reactome:R-HSA-9646399|reactome:R-HSA-975110|reactome:R-HSA-975144|reactome:R-HSA-983168|rcsb pdb:6ULH|rcsb pdb:6UMP|rcsb pdb:6UMS|rcsb pdb:7BBD|rcsb pdb:7BBF|rcsb pdb:7BXG|reactome:R-HSA-1169408|reactome:R-HSA-168638	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S3|resulting-ptm:Q8TEB9 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:EwhjYjowkZIAt4UyPcZBUtf9uak10116	rogid:dqdszHlq5FLPHC6UWX6uvkC6Yz89606	intact-crc:8574CFA998BFD312|rigid:L8KFsd2fn1mXEkVroumuztYq8rA	false	sufficient binding region:433-481(IPR013083)	his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q62925	uniprotkb:Q8WVD5	intact:EBI-636664	intact:EBI-4308142|uniprotkb:A8K149|uniprotkb:Q9NZB4|ensembl:ENSP00000265981	psi-mi:m3k1_rat(display_long)|uniprotkb:MAPK/ERK kinase kinase 1(gene name synonym)|uniprotkb:Map3k1(gene name)|psi-mi:Map3k1(display_short)|uniprotkb:Mekk(gene name synonym)|uniprotkb:Mekk1(gene name synonym)	psi-mi:rn141_human(display_long)|uniprotkb:RNF141(gene name)|psi-mi:RNF141(display_short)|uniprotkb:ZNF230(gene name synonym)|uniprotkb:Zinc finger protein 230(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9972313|imex:IM-22822-106	author-confidence:Z-score = 9.85	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:620966|refseq:NP_446339.1|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR007527(Zinc finger, SWIM-type)|go:"GO:0000165"(MAPK cascade)|interpro:IPR016024(Armadillo-type fold)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0002011"(morphogenesis of an epithelial sheet)|go:"GO:0003382"(epithelial cell morphogenesis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004706"(JUN kinase kinase kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007254"(JNK cascade)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008432"(JUN kinase binding)|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0016020"(membrane)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0031434"(mitogen-activated protein kinase kinase binding)|go:"GO:0031941"(filamentous actin)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0042060"(wound healing)|go:"GO:0043010"(camera-type eye development)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046625"(sphingolipid binding)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050434"(positive regulation of viral transcription)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0061029"(eyelid development in camera-type eye)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|reactome:R-RNO-166058|reactome:R-RNO-2871796|reactome:R-RNO-975138|reactome:R-RNO-975871|interpro:IPR011989(Armadillo-like helical)|mint:Q62925	refseq:NP_057506.2|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0016020"(membrane)|go:"GO:0046872"(metal ion binding)|go:"GO:0051865"(protein autoubiquitination)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR043400|rcsb pdb:2ECN|rcsb pdb:5XEK|ensembl:ENST00000265981(transcript)|ensembl:ENSG00000110315(gene)	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S3|resulting-ptm:Q8WVD5 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:EwhjYjowkZIAt4UyPcZBUtf9uak10116	rogid:7TPOeObb58gh04opCkEFgsvhzMQ9606	intact-crc:AD94B42DA76B46F2|rigid:FfHaqVXrebZlSgNBhLgYiW3sLBg	false	sufficient binding region:433-481(IPR013083)	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q62925	uniprotkb:Q13404	intact:EBI-636664	intact:EBI-1050671|uniprotkb:Q13403|uniprotkb:Q13532|uniprotkb:Q96H34|uniprotkb:Q9GZT0|uniprotkb:Q9GZW1|uniprotkb:Q9H4J3|uniprotkb:Q9H4J4|uniprotkb:Q9UKL1|uniprotkb:Q9UM48|uniprotkb:Q9UM49|uniprotkb:Q9UM50|uniprotkb:Q5TGE3|uniprotkb:E1P629|uniprotkb:Q5TGE0|ensembl:ENSP00000360739	psi-mi:m3k1_rat(display_long)|uniprotkb:MAPK/ERK kinase kinase 1(gene name synonym)|uniprotkb:Map3k1(gene name)|psi-mi:Map3k1(display_short)|uniprotkb:Mekk(gene name synonym)|uniprotkb:Mekk1(gene name synonym)	psi-mi:ub2v1_human(display_long)|uniprotkb:CROC-1(gene name synonym)|uniprotkb:TRAF6-regulated IKK activator 1 beta Uev1A(gene name synonym)|uniprotkb:P/OKcl.19(orf name)|uniprotkb:UBE2V1(gene name)|psi-mi:UBE2V1(display_short)|uniprotkb:CROC1(gene name synonym)|uniprotkb:UBE2V(gene name synonym)|uniprotkb:UEV1(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9972313|imex:IM-22822-106	author-confidence:Z-score = 9.85	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:620966|refseq:NP_446339.1|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR007527(Zinc finger, SWIM-type)|go:"GO:0000165"(MAPK cascade)|interpro:IPR016024(Armadillo-type fold)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0002011"(morphogenesis of an epithelial sheet)|go:"GO:0003382"(epithelial cell morphogenesis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004706"(JUN kinase kinase kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007254"(JNK cascade)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008432"(JUN kinase binding)|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0016020"(membrane)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0031434"(mitogen-activated protein kinase kinase binding)|go:"GO:0031941"(filamentous actin)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0042060"(wound healing)|go:"GO:0043010"(camera-type eye development)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046625"(sphingolipid binding)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050434"(positive regulation of viral transcription)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0061029"(eyelid development in camera-type eye)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|reactome:R-RNO-166058|reactome:R-RNO-2871796|reactome:R-RNO-975138|reactome:R-RNO-975871|interpro:IPR011989(Armadillo-like helical)|mint:Q62925	refseq:NP_001027459.1|refseq:NP_068823.2|refseq:NP_071887.1|refseq:NP_954595.1|refseq:NP_954673.1|refseq:NP_001244322.1|refseq:NP_001244323.1|refseq:NP_001244325.1|ensembl:ENSG00000244687(gene)|ensembl:ENST00000371674(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006282"(regulation of DNA repair)|go:"GO:0006301"(postreplication repair)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0030154"(cell differentiation)|go:"GO:0031371"(ubiquitin conjugating enzyme complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035370"(UBC13-UEV1A complex)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070534"(protein K63-linked ubiquitination)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|rcsb pdb:2A4D|rcsb pdb:2C2V|rcsb pdb:2HLW|rcsb pdb:6D6I|reactome:R-HSA-168638|reactome:R-HSA-168927|reactome:R-HSA-202424|reactome:R-HSA-2871837|reactome:R-HSA-445989|reactome:R-HSA-450302|reactome:R-HSA-450321|reactome:R-HSA-5607764|reactome:R-HSA-9020702|reactome:R-HSA-937039|reactome:R-HSA-937041|reactome:R-HSA-9646399|reactome:R-HSA-975110|reactome:R-HSA-975144|reactome:R-HSA-983168|dip:DIP-41911N	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S3|resulting-ptm:Q8WVD5 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:EwhjYjowkZIAt4UyPcZBUtf9uak10116	rogid:x95N7Dj2KIqu5gySX59xLmfthUg9606	intact-crc:AD94B42DA76B46F2|rigid:FfHaqVXrebZlSgNBhLgYiW3sLBg	false	sufficient binding region:433-481(IPR013083)	his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q62925	uniprotkb:P22314	intact:EBI-636664	intact:EBI-709688|uniprotkb:Q96E13|uniprotkb:Q5JRR8|ensembl:ENSP00000338413|ensembl:ENSP00000366568	psi-mi:m3k1_rat(display_long)|uniprotkb:MAPK/ERK kinase kinase 1(gene name synonym)|uniprotkb:Map3k1(gene name)|psi-mi:Map3k1(display_short)|uniprotkb:Mekk(gene name synonym)|uniprotkb:Mekk1(gene name synonym)	psi-mi:uba1_human(display_long)|uniprotkb:Ubiquitin-activating enzyme E1(gene name synonym)|uniprotkb:Protein A1S9(gene name synonym)|uniprotkb:UBA1(gene name)|psi-mi:UBA1(display_short)|uniprotkb:A1S9T(gene name synonym)|uniprotkb:UBE1(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9972313|imex:IM-22822-106	author-confidence:Z-score = 9.85	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:620966|refseq:NP_446339.1|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR007527(Zinc finger, SWIM-type)|go:"GO:0000165"(MAPK cascade)|interpro:IPR016024(Armadillo-type fold)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0002011"(morphogenesis of an epithelial sheet)|go:"GO:0003382"(epithelial cell morphogenesis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004706"(JUN kinase kinase kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007254"(JNK cascade)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008432"(JUN kinase binding)|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0016020"(membrane)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0031434"(mitogen-activated protein kinase kinase binding)|go:"GO:0031941"(filamentous actin)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0042060"(wound healing)|go:"GO:0043010"(camera-type eye development)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046625"(sphingolipid binding)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050434"(positive regulation of viral transcription)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0061029"(eyelid development in camera-type eye)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|reactome:R-RNO-166058|reactome:R-RNO-2871796|reactome:R-RNO-975138|reactome:R-RNO-975871|interpro:IPR011989(Armadillo-like helical)|mint:Q62925	refseq:NP_003325.2|refseq:NP_695012.1|refseq:XP_016885269.1|refseq:XP_016885270.1|dip:DIP-33686N|ensembl:ENSG00000130985(gene)|ensembl:ENST00000335972(transcript)|ensembl:ENST00000377351(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0004839"(ubiquitin activating enzyme activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0032446"(protein modification by small protein conjugation)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000011(Ubiquitin-activating enzyme, E1)|interpro:IPR000594(UBA/THIF-type NAD/FAD binding fold)|interpro:IPR018074|interpro:IPR018075|interpro:IPR018965|interpro:IPR019572|interpro:IPR032418|interpro:IPR032420|interpro:IPR033127|interpro:IPR035985|interpro:IPR038252|interpro:IPR042063|interpro:IPR042302|interpro:IPR042449|mint:P22314|rcsb pdb:4P22|rcsb pdb:6DC6|reactome:R-HSA-8866652|reactome:R-HSA-983168	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S3|resulting-ptm:Q8WVD5 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:EwhjYjowkZIAt4UyPcZBUtf9uak10116	rogid:q+vEeA0XLST0Zz173bmEt0dNbDE9606	intact-crc:AD94B42DA76B46F2|rigid:FfHaqVXrebZlSgNBhLgYiW3sLBg	false	sufficient binding region:433-481(IPR013083)	his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q62925	uniprotkb:P61088	intact:EBI-636664	intact:EBI-1052908|uniprotkb:Q16781|uniprotkb:Q53Y81|ensembl:ENSP00000316176	psi-mi:m3k1_rat(display_long)|uniprotkb:MAPK/ERK kinase kinase 1(gene name synonym)|uniprotkb:Map3k1(gene name)|psi-mi:Map3k1(display_short)|uniprotkb:Mekk(gene name synonym)|uniprotkb:Mekk1(gene name synonym)	psi-mi:ube2n_human(display_long)|uniprotkb:Ubiquitin-protein ligase N(gene name synonym)|uniprotkb:Ubiquitin carrier protein N(gene name synonym)|uniprotkb:Ubc13(gene name synonym)|uniprotkb:Bendless-like ubiquitin-conjugating enzyme(gene name synonym)|uniprotkb:UBE2N(gene name)|psi-mi:UBE2N(display_short)|uniprotkb:BLU(gene name synonym)|uniprotkb:UbcH13(gene name synonym)|uniprotkb:E2 ubiquitin-conjugating enzyme N(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9972313|imex:IM-22822-106	author-confidence:Z-score = 9.85	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:620966|refseq:NP_446339.1|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR007527(Zinc finger, SWIM-type)|go:"GO:0000165"(MAPK cascade)|interpro:IPR016024(Armadillo-type fold)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0002011"(morphogenesis of an epithelial sheet)|go:"GO:0003382"(epithelial cell morphogenesis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004706"(JUN kinase kinase kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007254"(JNK cascade)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008432"(JUN kinase binding)|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0016020"(membrane)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0031434"(mitogen-activated protein kinase kinase binding)|go:"GO:0031941"(filamentous actin)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0042060"(wound healing)|go:"GO:0043010"(camera-type eye development)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046625"(sphingolipid binding)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050434"(positive regulation of viral transcription)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0061029"(eyelid development in camera-type eye)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|reactome:R-RNO-166058|reactome:R-RNO-2871796|reactome:R-RNO-975138|reactome:R-RNO-975871|interpro:IPR011989(Armadillo-like helical)|mint:Q62925	refseq:NP_003339.1|dip:DIP-29829N|ensembl:ENSG00000177889(gene)|ensembl:ENST00000318066(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000729"(DNA double-strand break processing)|go:"GO:0001650"(fibrillar center)|go:"GO:0003723"(RNA binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006282"(regulation of DNA repair)|go:"GO:0006301"(postreplication repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016574"(histone ubiquitination)|go:"GO:0031058"(positive regulation of histone modification)|go:"GO:0031372"(UBC13-MMS2 complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033182"(regulation of histone ubiquitination)|go:"GO:0035370"(UBC13-UEV1A complex)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0061631"(ubiquitin conjugating enzyme activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070534"(protein K63-linked ubiquitination)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|interpro:IPR023313|rcsb pdb:1J7D|rcsb pdb:2C2V|rcsb pdb:3HCT|rcsb pdb:3HCU|rcsb pdb:3VON|rcsb pdb:3W31|rcsb pdb:4DHI|rcsb pdb:4DHJ|rcsb pdb:4DHZ|rcsb pdb:4IP3|rcsb pdb:4NR3|rcsb pdb:4NRG|rcsb pdb:4NRI|rcsb pdb:4ONL|rcsb pdb:4ONM|rcsb pdb:4ONN|rcsb pdb:4ORH|rcsb pdb:4TKP|rcsb pdb:4WHV|rcsb pdb:5AIT|rcsb pdb:5AIU|rcsb pdb:5EYA|rcsb pdb:5H7S|rcsb pdb:5VNZ|rcsb pdb:5VO0|rcsb pdb:5YWR|rcsb pdb:6D6I|rcsb pdb:6JKY|rcsb pdb:6KFP|rcsb pdb:6KG6|rcsb pdb:6KL4|rcsb pdb:6LP2|rcsb pdb:6P5B|rcsb pdb:6S53|reactome:R-HSA-168927|reactome:R-HSA-202424|reactome:R-HSA-2871837|reactome:R-HSA-445989|reactome:R-HSA-450302|reactome:R-HSA-450321|reactome:R-HSA-5607764|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-5696395|reactome:R-HSA-69473|reactome:R-HSA-8866654|reactome:R-HSA-9020702|reactome:R-HSA-937039|reactome:R-HSA-937041|reactome:R-HSA-9646399|reactome:R-HSA-975110|reactome:R-HSA-975144|reactome:R-HSA-983168|rcsb pdb:6ULH|rcsb pdb:6UMP|rcsb pdb:6UMS|rcsb pdb:7BBD|rcsb pdb:7BBF|rcsb pdb:7BXG|reactome:R-HSA-1169408|reactome:R-HSA-168638	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S3|resulting-ptm:Q8WVD5 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:EwhjYjowkZIAt4UyPcZBUtf9uak10116	rogid:dqdszHlq5FLPHC6UWX6uvkC6Yz89606	intact-crc:AD94B42DA76B46F2|rigid:FfHaqVXrebZlSgNBhLgYiW3sLBg	false	sufficient binding region:433-481(IPR013083)	his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q62925	uniprotkb:Q92783	intact:EBI-636664	intact:EBI-752333|uniprotkb:Q8N6D9|uniprotkb:B0YJ99|intact:EBI-3447129|uniprotkb:D3DRU5|intact:EBI-28983444|ensembl:ENSP00000366746	psi-mi:m3k1_rat(display_long)|uniprotkb:MAPK/ERK kinase kinase 1(gene name synonym)|uniprotkb:Map3k1(gene name)|psi-mi:Map3k1(display_short)|uniprotkb:Mekk(gene name synonym)|uniprotkb:Mekk1(gene name synonym)	psi-mi:stam1_human(display_long)|uniprotkb:STAM(gene name)|psi-mi:STAM(display_short)|uniprotkb:STAM1(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9972363|imex:IM-22822-108	author-confidence:Z-score = 10.76	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:620966|refseq:NP_446339.1|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR007527(Zinc finger, SWIM-type)|go:"GO:0000165"(MAPK cascade)|interpro:IPR016024(Armadillo-type fold)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0002011"(morphogenesis of an epithelial sheet)|go:"GO:0003382"(epithelial cell morphogenesis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004706"(JUN kinase kinase kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007254"(JNK cascade)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008432"(JUN kinase binding)|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0016020"(membrane)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0031434"(mitogen-activated protein kinase kinase binding)|go:"GO:0031941"(filamentous actin)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0042060"(wound healing)|go:"GO:0043010"(camera-type eye development)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046625"(sphingolipid binding)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050434"(positive regulation of viral transcription)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0061029"(eyelid development in camera-type eye)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|reactome:R-RNO-166058|reactome:R-RNO-2871796|reactome:R-RNO-975138|reactome:R-RNO-975871|interpro:IPR011989(Armadillo-like helical)|mint:Q62925	refseq:NP_003464.1|ensembl:ENSP00000366746|dip:DIP-37761N|go:"GO:0043328"(protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway)|go:"GO:0044389"(ubiquitin-like protein ligase binding)|go:"GO:1903543"(positive regulation of exosomal secretion)|go:"GO:1903551"(regulation of extracellular exosome assembly)|interpro:IPR001452(Src homology-3)|interpro:IPR002014(VHS)|interpro:IPR003903(Ubiquitin interacting motif)|interpro:IPR008942(ENTH/VHS)|interpro:IPR035657|interpro:IPR036028|mint:Q92783|rcsb pdb:2L0A|rcsb pdb:3F1I|rcsb pdb:3LDZ|reactome:R-HSA-182971|reactome:R-HSA-5689901|reactome:R-HSA-6807004|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-8875360|reactome:R-HSA-9013420|reactome:R-HSA-917729|ensembl:ENSG00000136738(gene)|ensembl:ENST00000377524(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0007165"(signal transduction)|go:"GO:0016236"(macroautophagy)|go:"GO:0031901"(early endosome membrane)|go:"GO:0033565"(ESCRT-0 complex)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0036258"(multivesicular body assembly)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S3|resulting-ptm:Q92783 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:EwhjYjowkZIAt4UyPcZBUtf9uak10116	rogid:+XzmsTsMqOFTM5SM1fuVB+0UzeQ9606	intact-crc:B218847C246661C3|rigid:EZXdXMoAOoHgKfG2MQSX3FUrIzA	false	sufficient binding region:433-481(IPR013083)	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q62925	uniprotkb:Q13404	intact:EBI-636664	intact:EBI-1050671|uniprotkb:Q13403|uniprotkb:Q13532|uniprotkb:Q96H34|uniprotkb:Q9GZT0|uniprotkb:Q9GZW1|uniprotkb:Q9H4J3|uniprotkb:Q9H4J4|uniprotkb:Q9UKL1|uniprotkb:Q9UM48|uniprotkb:Q9UM49|uniprotkb:Q9UM50|uniprotkb:Q5TGE3|uniprotkb:E1P629|uniprotkb:Q5TGE0|ensembl:ENSP00000360739	psi-mi:m3k1_rat(display_long)|uniprotkb:MAPK/ERK kinase kinase 1(gene name synonym)|uniprotkb:Map3k1(gene name)|psi-mi:Map3k1(display_short)|uniprotkb:Mekk(gene name synonym)|uniprotkb:Mekk1(gene name synonym)	psi-mi:ub2v1_human(display_long)|uniprotkb:CROC-1(gene name synonym)|uniprotkb:TRAF6-regulated IKK activator 1 beta Uev1A(gene name synonym)|uniprotkb:P/OKcl.19(orf name)|uniprotkb:UBE2V1(gene name)|psi-mi:UBE2V1(display_short)|uniprotkb:CROC1(gene name synonym)|uniprotkb:UBE2V(gene name synonym)|uniprotkb:UEV1(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9972363|imex:IM-22822-108	author-confidence:Z-score = 10.76	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:620966|refseq:NP_446339.1|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR007527(Zinc finger, SWIM-type)|go:"GO:0000165"(MAPK cascade)|interpro:IPR016024(Armadillo-type fold)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0002011"(morphogenesis of an epithelial sheet)|go:"GO:0003382"(epithelial cell morphogenesis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004706"(JUN kinase kinase kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007254"(JNK cascade)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008432"(JUN kinase binding)|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0016020"(membrane)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0031434"(mitogen-activated protein kinase kinase binding)|go:"GO:0031941"(filamentous actin)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0042060"(wound healing)|go:"GO:0043010"(camera-type eye development)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046625"(sphingolipid binding)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050434"(positive regulation of viral transcription)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0061029"(eyelid development in camera-type eye)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|reactome:R-RNO-166058|reactome:R-RNO-2871796|reactome:R-RNO-975138|reactome:R-RNO-975871|interpro:IPR011989(Armadillo-like helical)|mint:Q62925	refseq:NP_001027459.1|refseq:NP_068823.2|refseq:NP_071887.1|refseq:NP_954595.1|refseq:NP_954673.1|refseq:NP_001244322.1|refseq:NP_001244323.1|refseq:NP_001244325.1|ensembl:ENSG00000244687(gene)|ensembl:ENST00000371674(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006282"(regulation of DNA repair)|go:"GO:0006301"(postreplication repair)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0030154"(cell differentiation)|go:"GO:0031371"(ubiquitin conjugating enzyme complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035370"(UBC13-UEV1A complex)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070534"(protein K63-linked ubiquitination)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|rcsb pdb:2A4D|rcsb pdb:2C2V|rcsb pdb:2HLW|rcsb pdb:6D6I|reactome:R-HSA-168638|reactome:R-HSA-168927|reactome:R-HSA-202424|reactome:R-HSA-2871837|reactome:R-HSA-445989|reactome:R-HSA-450302|reactome:R-HSA-450321|reactome:R-HSA-5607764|reactome:R-HSA-9020702|reactome:R-HSA-937039|reactome:R-HSA-937041|reactome:R-HSA-9646399|reactome:R-HSA-975110|reactome:R-HSA-975144|reactome:R-HSA-983168|dip:DIP-41911N	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S3|resulting-ptm:Q92783 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:EwhjYjowkZIAt4UyPcZBUtf9uak10116	rogid:x95N7Dj2KIqu5gySX59xLmfthUg9606	intact-crc:B218847C246661C3|rigid:EZXdXMoAOoHgKfG2MQSX3FUrIzA	false	sufficient binding region:433-481(IPR013083)	his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q62925	uniprotkb:P22314	intact:EBI-636664	intact:EBI-709688|uniprotkb:Q96E13|uniprotkb:Q5JRR8|ensembl:ENSP00000338413|ensembl:ENSP00000366568	psi-mi:m3k1_rat(display_long)|uniprotkb:MAPK/ERK kinase kinase 1(gene name synonym)|uniprotkb:Map3k1(gene name)|psi-mi:Map3k1(display_short)|uniprotkb:Mekk(gene name synonym)|uniprotkb:Mekk1(gene name synonym)	psi-mi:uba1_human(display_long)|uniprotkb:Ubiquitin-activating enzyme E1(gene name synonym)|uniprotkb:Protein A1S9(gene name synonym)|uniprotkb:UBA1(gene name)|psi-mi:UBA1(display_short)|uniprotkb:A1S9T(gene name synonym)|uniprotkb:UBE1(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9972363|imex:IM-22822-108	author-confidence:Z-score = 10.76	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:620966|refseq:NP_446339.1|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR007527(Zinc finger, SWIM-type)|go:"GO:0000165"(MAPK cascade)|interpro:IPR016024(Armadillo-type fold)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0002011"(morphogenesis of an epithelial sheet)|go:"GO:0003382"(epithelial cell morphogenesis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004706"(JUN kinase kinase kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007254"(JNK cascade)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008432"(JUN kinase binding)|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0016020"(membrane)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0031434"(mitogen-activated protein kinase kinase binding)|go:"GO:0031941"(filamentous actin)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0042060"(wound healing)|go:"GO:0043010"(camera-type eye development)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046625"(sphingolipid binding)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050434"(positive regulation of viral transcription)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0061029"(eyelid development in camera-type eye)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|reactome:R-RNO-166058|reactome:R-RNO-2871796|reactome:R-RNO-975138|reactome:R-RNO-975871|interpro:IPR011989(Armadillo-like helical)|mint:Q62925	refseq:NP_003325.2|refseq:NP_695012.1|refseq:XP_016885269.1|refseq:XP_016885270.1|dip:DIP-33686N|ensembl:ENSG00000130985(gene)|ensembl:ENST00000335972(transcript)|ensembl:ENST00000377351(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0004839"(ubiquitin activating enzyme activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0032446"(protein modification by small protein conjugation)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000011(Ubiquitin-activating enzyme, E1)|interpro:IPR000594(UBA/THIF-type NAD/FAD binding fold)|interpro:IPR018074|interpro:IPR018075|interpro:IPR018965|interpro:IPR019572|interpro:IPR032418|interpro:IPR032420|interpro:IPR033127|interpro:IPR035985|interpro:IPR038252|interpro:IPR042063|interpro:IPR042302|interpro:IPR042449|mint:P22314|rcsb pdb:4P22|rcsb pdb:6DC6|reactome:R-HSA-8866652|reactome:R-HSA-983168	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S3|resulting-ptm:Q92783 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:EwhjYjowkZIAt4UyPcZBUtf9uak10116	rogid:q+vEeA0XLST0Zz173bmEt0dNbDE9606	intact-crc:B218847C246661C3|rigid:EZXdXMoAOoHgKfG2MQSX3FUrIzA	false	sufficient binding region:433-481(IPR013083)	his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q62925	uniprotkb:P61088	intact:EBI-636664	intact:EBI-1052908|uniprotkb:Q16781|uniprotkb:Q53Y81|ensembl:ENSP00000316176	psi-mi:m3k1_rat(display_long)|uniprotkb:MAPK/ERK kinase kinase 1(gene name synonym)|uniprotkb:Map3k1(gene name)|psi-mi:Map3k1(display_short)|uniprotkb:Mekk(gene name synonym)|uniprotkb:Mekk1(gene name synonym)	psi-mi:ube2n_human(display_long)|uniprotkb:Ubiquitin-protein ligase N(gene name synonym)|uniprotkb:Ubiquitin carrier protein N(gene name synonym)|uniprotkb:Ubc13(gene name synonym)|uniprotkb:Bendless-like ubiquitin-conjugating enzyme(gene name synonym)|uniprotkb:UBE2N(gene name)|psi-mi:UBE2N(display_short)|uniprotkb:BLU(gene name synonym)|uniprotkb:UbcH13(gene name synonym)|uniprotkb:E2 ubiquitin-conjugating enzyme N(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9972363|imex:IM-22822-108	author-confidence:Z-score = 10.76	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:620966|refseq:NP_446339.1|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR007527(Zinc finger, SWIM-type)|go:"GO:0000165"(MAPK cascade)|interpro:IPR016024(Armadillo-type fold)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0002011"(morphogenesis of an epithelial sheet)|go:"GO:0003382"(epithelial cell morphogenesis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004706"(JUN kinase kinase kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007254"(JNK cascade)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008432"(JUN kinase binding)|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0016020"(membrane)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0031434"(mitogen-activated protein kinase kinase binding)|go:"GO:0031941"(filamentous actin)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0042060"(wound healing)|go:"GO:0043010"(camera-type eye development)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046625"(sphingolipid binding)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050434"(positive regulation of viral transcription)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0061029"(eyelid development in camera-type eye)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|reactome:R-RNO-166058|reactome:R-RNO-2871796|reactome:R-RNO-975138|reactome:R-RNO-975871|interpro:IPR011989(Armadillo-like helical)|mint:Q62925	refseq:NP_003339.1|dip:DIP-29829N|ensembl:ENSG00000177889(gene)|ensembl:ENST00000318066(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000729"(DNA double-strand break processing)|go:"GO:0001650"(fibrillar center)|go:"GO:0003723"(RNA binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006282"(regulation of DNA repair)|go:"GO:0006301"(postreplication repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016574"(histone ubiquitination)|go:"GO:0031058"(positive regulation of histone modification)|go:"GO:0031372"(UBC13-MMS2 complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033182"(regulation of histone ubiquitination)|go:"GO:0035370"(UBC13-UEV1A complex)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0061631"(ubiquitin conjugating enzyme activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070534"(protein K63-linked ubiquitination)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|interpro:IPR023313|rcsb pdb:1J7D|rcsb pdb:2C2V|rcsb pdb:3HCT|rcsb pdb:3HCU|rcsb pdb:3VON|rcsb pdb:3W31|rcsb pdb:4DHI|rcsb pdb:4DHJ|rcsb pdb:4DHZ|rcsb pdb:4IP3|rcsb pdb:4NR3|rcsb pdb:4NRG|rcsb pdb:4NRI|rcsb pdb:4ONL|rcsb pdb:4ONM|rcsb pdb:4ONN|rcsb pdb:4ORH|rcsb pdb:4TKP|rcsb pdb:4WHV|rcsb pdb:5AIT|rcsb pdb:5AIU|rcsb pdb:5EYA|rcsb pdb:5H7S|rcsb pdb:5VNZ|rcsb pdb:5VO0|rcsb pdb:5YWR|rcsb pdb:6D6I|rcsb pdb:6JKY|rcsb pdb:6KFP|rcsb pdb:6KG6|rcsb pdb:6KL4|rcsb pdb:6LP2|rcsb pdb:6P5B|rcsb pdb:6S53|reactome:R-HSA-168927|reactome:R-HSA-202424|reactome:R-HSA-2871837|reactome:R-HSA-445989|reactome:R-HSA-450302|reactome:R-HSA-450321|reactome:R-HSA-5607764|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-5696395|reactome:R-HSA-69473|reactome:R-HSA-8866654|reactome:R-HSA-9020702|reactome:R-HSA-937039|reactome:R-HSA-937041|reactome:R-HSA-9646399|reactome:R-HSA-975110|reactome:R-HSA-975144|reactome:R-HSA-983168|rcsb pdb:6ULH|rcsb pdb:6UMP|rcsb pdb:6UMS|rcsb pdb:7BBD|rcsb pdb:7BBF|rcsb pdb:7BXG|reactome:R-HSA-1169408|reactome:R-HSA-168638	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S3|resulting-ptm:Q92783 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:EwhjYjowkZIAt4UyPcZBUtf9uak10116	rogid:dqdszHlq5FLPHC6UWX6uvkC6Yz89606	intact-crc:B218847C246661C3|rigid:EZXdXMoAOoHgKfG2MQSX3FUrIzA	false	sufficient binding region:433-481(IPR013083)	his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q92560	uniprotkb:Q62925	intact:EBI-1791447|uniprotkb:Q6LEM0|uniprotkb:Q7Z5E8|uniprotkb:A8K993|intact:EBI-2558090|ensembl:ENSP00000417132	intact:EBI-636664	psi-mi:bap1_human(display_long)|uniprotkb:BAP1(gene name)|psi-mi:BAP1(display_short)|uniprotkb:KIAA0272(gene name synonym)|uniprotkb:hucep-6(orf name)|uniprotkb:BRCA1-associated protein 1(gene name synonym)|uniprotkb:Cerebral protein 6(gene name synonym)	psi-mi:m3k1_rat(display_long)|uniprotkb:MAPK/ERK kinase kinase 1(gene name synonym)|uniprotkb:Map3k1(gene name)|psi-mi:Map3k1(display_short)|uniprotkb:Mekk(gene name synonym)|uniprotkb:Mekk1(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9972338|imex:IM-22822-107	author-confidence:Z-score = 10.80	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	dip:DIP-47004N|refseq:NP_004647.1|ensembl:ENSG00000163930(gene)|ensembl:ENST00000460680(transcript)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0003682"(chromatin binding)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006464"(cellular protein modification process)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008233"(peptidase activity)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010035"(response to inorganic substance)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0035517"(PR-DUB complex)|go:"GO:0035520"(monoubiquitinated protein deubiquitination)|go:"GO:0035522"(monoubiquitinated histone H2A deubiquitination)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0061519"(macrophage homeostasis)|go:"GO:0071108"(protein K48-linked deubiquitination)|go:"GO:1900015"(regulation of cytokine production involved in inflammatory response)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|interpro:IPR001578(Peptidase C12, ubiquitin carboxyl-terminal hydrolase 1)|interpro:IPR036959|interpro:IPR038765|interpro:IPR041507|mint:Q92560|reactome:R-HSA-5689603|reactome:R-HSA-5693565	rgd:620966|refseq:NP_446339.1|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR007527(Zinc finger, SWIM-type)|go:"GO:0000165"(MAPK cascade)|interpro:IPR016024(Armadillo-type fold)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0002011"(morphogenesis of an epithelial sheet)|go:"GO:0003382"(epithelial cell morphogenesis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004706"(JUN kinase kinase kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007254"(JNK cascade)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008432"(JUN kinase binding)|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0016020"(membrane)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0031434"(mitogen-activated protein kinase kinase binding)|go:"GO:0031941"(filamentous actin)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0042060"(wound healing)|go:"GO:0043010"(camera-type eye development)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046625"(sphingolipid binding)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050434"(positive regulation of viral transcription)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0061029"(eyelid development in camera-type eye)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|reactome:R-RNO-166058|reactome:R-RNO-2871796|reactome:R-RNO-975138|reactome:R-RNO-975871|interpro:IPR011989(Armadillo-like helical)|mint:Q62925	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S3|resulting-ptm:Q92560 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:GMWdT1u5HUl29N+YgC/bCKTbxm49606	rogid:EwhjYjowkZIAt4UyPcZBUtf9uak10116	intact-crc:8AD655361B06FAD5|rigid:Vk4TvOrgVklHWOkua705QnP0uR8	false	-	sufficient binding region:433-481(IPR013083)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q92560	uniprotkb:Q13404	intact:EBI-1791447|uniprotkb:Q6LEM0|uniprotkb:Q7Z5E8|uniprotkb:A8K993|intact:EBI-2558090|ensembl:ENSP00000417132	intact:EBI-1050671|uniprotkb:Q13403|uniprotkb:Q13532|uniprotkb:Q96H34|uniprotkb:Q9GZT0|uniprotkb:Q9GZW1|uniprotkb:Q9H4J3|uniprotkb:Q9H4J4|uniprotkb:Q9UKL1|uniprotkb:Q9UM48|uniprotkb:Q9UM49|uniprotkb:Q9UM50|uniprotkb:Q5TGE3|uniprotkb:E1P629|uniprotkb:Q5TGE0|ensembl:ENSP00000360739	psi-mi:bap1_human(display_long)|uniprotkb:BAP1(gene name)|psi-mi:BAP1(display_short)|uniprotkb:KIAA0272(gene name synonym)|uniprotkb:hucep-6(orf name)|uniprotkb:BRCA1-associated protein 1(gene name synonym)|uniprotkb:Cerebral protein 6(gene name synonym)	psi-mi:ub2v1_human(display_long)|uniprotkb:CROC-1(gene name synonym)|uniprotkb:TRAF6-regulated IKK activator 1 beta Uev1A(gene name synonym)|uniprotkb:P/OKcl.19(orf name)|uniprotkb:UBE2V1(gene name)|psi-mi:UBE2V1(display_short)|uniprotkb:CROC1(gene name synonym)|uniprotkb:UBE2V(gene name synonym)|uniprotkb:UEV1(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9972338|imex:IM-22822-107	author-confidence:Z-score = 10.80	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	dip:DIP-47004N|refseq:NP_004647.1|ensembl:ENSG00000163930(gene)|ensembl:ENST00000460680(transcript)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0003682"(chromatin binding)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006464"(cellular protein modification process)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008233"(peptidase activity)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010035"(response to inorganic substance)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0035517"(PR-DUB complex)|go:"GO:0035520"(monoubiquitinated protein deubiquitination)|go:"GO:0035522"(monoubiquitinated histone H2A deubiquitination)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0061519"(macrophage homeostasis)|go:"GO:0071108"(protein K48-linked deubiquitination)|go:"GO:1900015"(regulation of cytokine production involved in inflammatory response)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|interpro:IPR001578(Peptidase C12, ubiquitin carboxyl-terminal hydrolase 1)|interpro:IPR036959|interpro:IPR038765|interpro:IPR041507|mint:Q92560|reactome:R-HSA-5689603|reactome:R-HSA-5693565	refseq:NP_001027459.1|refseq:NP_068823.2|refseq:NP_071887.1|refseq:NP_954595.1|refseq:NP_954673.1|refseq:NP_001244322.1|refseq:NP_001244323.1|refseq:NP_001244325.1|ensembl:ENSG00000244687(gene)|ensembl:ENST00000371674(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006282"(regulation of DNA repair)|go:"GO:0006301"(postreplication repair)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0030154"(cell differentiation)|go:"GO:0031371"(ubiquitin conjugating enzyme complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035370"(UBC13-UEV1A complex)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070534"(protein K63-linked ubiquitination)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|rcsb pdb:2A4D|rcsb pdb:2C2V|rcsb pdb:2HLW|rcsb pdb:6D6I|reactome:R-HSA-168638|reactome:R-HSA-168927|reactome:R-HSA-202424|reactome:R-HSA-2871837|reactome:R-HSA-445989|reactome:R-HSA-450302|reactome:R-HSA-450321|reactome:R-HSA-5607764|reactome:R-HSA-9020702|reactome:R-HSA-937039|reactome:R-HSA-937041|reactome:R-HSA-9646399|reactome:R-HSA-975110|reactome:R-HSA-975144|reactome:R-HSA-983168|dip:DIP-41911N	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S3|resulting-ptm:Q92560 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:GMWdT1u5HUl29N+YgC/bCKTbxm49606	rogid:x95N7Dj2KIqu5gySX59xLmfthUg9606	intact-crc:8AD655361B06FAD5|rigid:Vk4TvOrgVklHWOkua705QnP0uR8	false	-	his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q92560	uniprotkb:P22314	intact:EBI-1791447|uniprotkb:Q6LEM0|uniprotkb:Q7Z5E8|uniprotkb:A8K993|intact:EBI-2558090|ensembl:ENSP00000417132	intact:EBI-709688|uniprotkb:Q96E13|uniprotkb:Q5JRR8|ensembl:ENSP00000338413|ensembl:ENSP00000366568	psi-mi:bap1_human(display_long)|uniprotkb:BAP1(gene name)|psi-mi:BAP1(display_short)|uniprotkb:KIAA0272(gene name synonym)|uniprotkb:hucep-6(orf name)|uniprotkb:BRCA1-associated protein 1(gene name synonym)|uniprotkb:Cerebral protein 6(gene name synonym)	psi-mi:uba1_human(display_long)|uniprotkb:Ubiquitin-activating enzyme E1(gene name synonym)|uniprotkb:Protein A1S9(gene name synonym)|uniprotkb:UBA1(gene name)|psi-mi:UBA1(display_short)|uniprotkb:A1S9T(gene name synonym)|uniprotkb:UBE1(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9972338|imex:IM-22822-107	author-confidence:Z-score = 10.80	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	dip:DIP-47004N|refseq:NP_004647.1|ensembl:ENSG00000163930(gene)|ensembl:ENST00000460680(transcript)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0003682"(chromatin binding)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006464"(cellular protein modification process)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008233"(peptidase activity)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010035"(response to inorganic substance)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0035517"(PR-DUB complex)|go:"GO:0035520"(monoubiquitinated protein deubiquitination)|go:"GO:0035522"(monoubiquitinated histone H2A deubiquitination)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0061519"(macrophage homeostasis)|go:"GO:0071108"(protein K48-linked deubiquitination)|go:"GO:1900015"(regulation of cytokine production involved in inflammatory response)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|interpro:IPR001578(Peptidase C12, ubiquitin carboxyl-terminal hydrolase 1)|interpro:IPR036959|interpro:IPR038765|interpro:IPR041507|mint:Q92560|reactome:R-HSA-5689603|reactome:R-HSA-5693565	refseq:NP_003325.2|refseq:NP_695012.1|refseq:XP_016885269.1|refseq:XP_016885270.1|dip:DIP-33686N|ensembl:ENSG00000130985(gene)|ensembl:ENST00000335972(transcript)|ensembl:ENST00000377351(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0004839"(ubiquitin activating enzyme activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0032446"(protein modification by small protein conjugation)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000011(Ubiquitin-activating enzyme, E1)|interpro:IPR000594(UBA/THIF-type NAD/FAD binding fold)|interpro:IPR018074|interpro:IPR018075|interpro:IPR018965|interpro:IPR019572|interpro:IPR032418|interpro:IPR032420|interpro:IPR033127|interpro:IPR035985|interpro:IPR038252|interpro:IPR042063|interpro:IPR042302|interpro:IPR042449|mint:P22314|rcsb pdb:4P22|rcsb pdb:6DC6|reactome:R-HSA-8866652|reactome:R-HSA-983168	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S3|resulting-ptm:Q92560 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:GMWdT1u5HUl29N+YgC/bCKTbxm49606	rogid:q+vEeA0XLST0Zz173bmEt0dNbDE9606	intact-crc:8AD655361B06FAD5|rigid:Vk4TvOrgVklHWOkua705QnP0uR8	false	-	his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q92560	uniprotkb:P61088	intact:EBI-1791447|uniprotkb:Q6LEM0|uniprotkb:Q7Z5E8|uniprotkb:A8K993|intact:EBI-2558090|ensembl:ENSP00000417132	intact:EBI-1052908|uniprotkb:Q16781|uniprotkb:Q53Y81|ensembl:ENSP00000316176	psi-mi:bap1_human(display_long)|uniprotkb:BAP1(gene name)|psi-mi:BAP1(display_short)|uniprotkb:KIAA0272(gene name synonym)|uniprotkb:hucep-6(orf name)|uniprotkb:BRCA1-associated protein 1(gene name synonym)|uniprotkb:Cerebral protein 6(gene name synonym)	psi-mi:ube2n_human(display_long)|uniprotkb:Ubiquitin-protein ligase N(gene name synonym)|uniprotkb:Ubiquitin carrier protein N(gene name synonym)|uniprotkb:Ubc13(gene name synonym)|uniprotkb:Bendless-like ubiquitin-conjugating enzyme(gene name synonym)|uniprotkb:UBE2N(gene name)|psi-mi:UBE2N(display_short)|uniprotkb:BLU(gene name synonym)|uniprotkb:UbcH13(gene name synonym)|uniprotkb:E2 ubiquitin-conjugating enzyme N(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9972338|imex:IM-22822-107	author-confidence:Z-score = 10.80	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	dip:DIP-47004N|refseq:NP_004647.1|ensembl:ENSG00000163930(gene)|ensembl:ENST00000460680(transcript)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0003682"(chromatin binding)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006464"(cellular protein modification process)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008233"(peptidase activity)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010035"(response to inorganic substance)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0035517"(PR-DUB complex)|go:"GO:0035520"(monoubiquitinated protein deubiquitination)|go:"GO:0035522"(monoubiquitinated histone H2A deubiquitination)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0061519"(macrophage homeostasis)|go:"GO:0071108"(protein K48-linked deubiquitination)|go:"GO:1900015"(regulation of cytokine production involved in inflammatory response)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|interpro:IPR001578(Peptidase C12, ubiquitin carboxyl-terminal hydrolase 1)|interpro:IPR036959|interpro:IPR038765|interpro:IPR041507|mint:Q92560|reactome:R-HSA-5689603|reactome:R-HSA-5693565	refseq:NP_003339.1|dip:DIP-29829N|ensembl:ENSG00000177889(gene)|ensembl:ENST00000318066(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000729"(DNA double-strand break processing)|go:"GO:0001650"(fibrillar center)|go:"GO:0003723"(RNA binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006282"(regulation of DNA repair)|go:"GO:0006301"(postreplication repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016574"(histone ubiquitination)|go:"GO:0031058"(positive regulation of histone modification)|go:"GO:0031372"(UBC13-MMS2 complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033182"(regulation of histone ubiquitination)|go:"GO:0035370"(UBC13-UEV1A complex)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0061631"(ubiquitin conjugating enzyme activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070534"(protein K63-linked ubiquitination)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|interpro:IPR023313|rcsb pdb:1J7D|rcsb pdb:2C2V|rcsb pdb:3HCT|rcsb pdb:3HCU|rcsb pdb:3VON|rcsb pdb:3W31|rcsb pdb:4DHI|rcsb pdb:4DHJ|rcsb pdb:4DHZ|rcsb pdb:4IP3|rcsb pdb:4NR3|rcsb pdb:4NRG|rcsb pdb:4NRI|rcsb pdb:4ONL|rcsb pdb:4ONM|rcsb pdb:4ONN|rcsb pdb:4ORH|rcsb pdb:4TKP|rcsb pdb:4WHV|rcsb pdb:5AIT|rcsb pdb:5AIU|rcsb pdb:5EYA|rcsb pdb:5H7S|rcsb pdb:5VNZ|rcsb pdb:5VO0|rcsb pdb:5YWR|rcsb pdb:6D6I|rcsb pdb:6JKY|rcsb pdb:6KFP|rcsb pdb:6KG6|rcsb pdb:6KL4|rcsb pdb:6LP2|rcsb pdb:6P5B|rcsb pdb:6S53|reactome:R-HSA-168927|reactome:R-HSA-202424|reactome:R-HSA-2871837|reactome:R-HSA-445989|reactome:R-HSA-450302|reactome:R-HSA-450321|reactome:R-HSA-5607764|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-5696395|reactome:R-HSA-69473|reactome:R-HSA-8866654|reactome:R-HSA-9020702|reactome:R-HSA-937039|reactome:R-HSA-937041|reactome:R-HSA-9646399|reactome:R-HSA-975110|reactome:R-HSA-975144|reactome:R-HSA-983168|rcsb pdb:6ULH|rcsb pdb:6UMP|rcsb pdb:6UMS|rcsb pdb:7BBD|rcsb pdb:7BBF|rcsb pdb:7BXG|reactome:R-HSA-1169408|reactome:R-HSA-168638	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S3|resulting-ptm:Q92560 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:GMWdT1u5HUl29N+YgC/bCKTbxm49606	rogid:dqdszHlq5FLPHC6UWX6uvkC6Yz89606	intact-crc:8AD655361B06FAD5|rigid:Vk4TvOrgVklHWOkua705QnP0uR8	false	-	his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q62925	uniprotkb:Q13404	intact:EBI-636664	intact:EBI-1050671|uniprotkb:Q13403|uniprotkb:Q13532|uniprotkb:Q96H34|uniprotkb:Q9GZT0|uniprotkb:Q9GZW1|uniprotkb:Q9H4J3|uniprotkb:Q9H4J4|uniprotkb:Q9UKL1|uniprotkb:Q9UM48|uniprotkb:Q9UM49|uniprotkb:Q9UM50|uniprotkb:Q5TGE3|uniprotkb:E1P629|uniprotkb:Q5TGE0|ensembl:ENSP00000360739	psi-mi:m3k1_rat(display_long)|uniprotkb:MAPK/ERK kinase kinase 1(gene name synonym)|uniprotkb:Map3k1(gene name)|psi-mi:Map3k1(display_short)|uniprotkb:Mekk(gene name synonym)|uniprotkb:Mekk1(gene name synonym)	psi-mi:ub2v1_human(display_long)|uniprotkb:CROC-1(gene name synonym)|uniprotkb:TRAF6-regulated IKK activator 1 beta Uev1A(gene name synonym)|uniprotkb:P/OKcl.19(orf name)|uniprotkb:UBE2V1(gene name)|psi-mi:UBE2V1(display_short)|uniprotkb:CROC1(gene name synonym)|uniprotkb:UBE2V(gene name synonym)|uniprotkb:UEV1(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9972388|imex:IM-22822-109	author-confidence:Z-score = 5.43	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:620966|refseq:NP_446339.1|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR007527(Zinc finger, SWIM-type)|go:"GO:0000165"(MAPK cascade)|interpro:IPR016024(Armadillo-type fold)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0002011"(morphogenesis of an epithelial sheet)|go:"GO:0003382"(epithelial cell morphogenesis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004706"(JUN kinase kinase kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007254"(JNK cascade)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008432"(JUN kinase binding)|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0016020"(membrane)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0031434"(mitogen-activated protein kinase kinase binding)|go:"GO:0031941"(filamentous actin)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0042060"(wound healing)|go:"GO:0043010"(camera-type eye development)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046625"(sphingolipid binding)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050434"(positive regulation of viral transcription)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0061029"(eyelid development in camera-type eye)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|reactome:R-RNO-166058|reactome:R-RNO-2871796|reactome:R-RNO-975138|reactome:R-RNO-975871|interpro:IPR011989(Armadillo-like helical)|mint:Q62925	refseq:NP_001027459.1|refseq:NP_068823.2|refseq:NP_071887.1|refseq:NP_954595.1|refseq:NP_954673.1|refseq:NP_001244322.1|refseq:NP_001244323.1|refseq:NP_001244325.1|ensembl:ENSG00000244687(gene)|ensembl:ENST00000371674(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006282"(regulation of DNA repair)|go:"GO:0006301"(postreplication repair)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0030154"(cell differentiation)|go:"GO:0031371"(ubiquitin conjugating enzyme complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035370"(UBC13-UEV1A complex)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070534"(protein K63-linked ubiquitination)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|rcsb pdb:2A4D|rcsb pdb:2C2V|rcsb pdb:2HLW|rcsb pdb:6D6I|reactome:R-HSA-168638|reactome:R-HSA-168927|reactome:R-HSA-202424|reactome:R-HSA-2871837|reactome:R-HSA-445989|reactome:R-HSA-450302|reactome:R-HSA-450321|reactome:R-HSA-5607764|reactome:R-HSA-9020702|reactome:R-HSA-937039|reactome:R-HSA-937041|reactome:R-HSA-9646399|reactome:R-HSA-975110|reactome:R-HSA-975144|reactome:R-HSA-983168|dip:DIP-41911N	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S3|resulting-ptm:Q92890 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:EwhjYjowkZIAt4UyPcZBUtf9uak10116	rogid:x95N7Dj2KIqu5gySX59xLmfthUg9606	intact-crc:992F9F2994F56971|rigid:RmF0C13CI/U8+GVNFIzKdPOypM0	false	sufficient binding region:433-481(IPR013083)	his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q62925	uniprotkb:P22314	intact:EBI-636664	intact:EBI-709688|uniprotkb:Q96E13|uniprotkb:Q5JRR8|ensembl:ENSP00000338413|ensembl:ENSP00000366568	psi-mi:m3k1_rat(display_long)|uniprotkb:MAPK/ERK kinase kinase 1(gene name synonym)|uniprotkb:Map3k1(gene name)|psi-mi:Map3k1(display_short)|uniprotkb:Mekk(gene name synonym)|uniprotkb:Mekk1(gene name synonym)	psi-mi:uba1_human(display_long)|uniprotkb:Ubiquitin-activating enzyme E1(gene name synonym)|uniprotkb:Protein A1S9(gene name synonym)|uniprotkb:UBA1(gene name)|psi-mi:UBA1(display_short)|uniprotkb:A1S9T(gene name synonym)|uniprotkb:UBE1(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9972388|imex:IM-22822-109	author-confidence:Z-score = 5.43	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:620966|refseq:NP_446339.1|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR007527(Zinc finger, SWIM-type)|go:"GO:0000165"(MAPK cascade)|interpro:IPR016024(Armadillo-type fold)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0002011"(morphogenesis of an epithelial sheet)|go:"GO:0003382"(epithelial cell morphogenesis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004706"(JUN kinase kinase kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007254"(JNK cascade)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008432"(JUN kinase binding)|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0016020"(membrane)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0031434"(mitogen-activated protein kinase kinase binding)|go:"GO:0031941"(filamentous actin)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0042060"(wound healing)|go:"GO:0043010"(camera-type eye development)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046625"(sphingolipid binding)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050434"(positive regulation of viral transcription)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0061029"(eyelid development in camera-type eye)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|reactome:R-RNO-166058|reactome:R-RNO-2871796|reactome:R-RNO-975138|reactome:R-RNO-975871|interpro:IPR011989(Armadillo-like helical)|mint:Q62925	refseq:NP_003325.2|refseq:NP_695012.1|refseq:XP_016885269.1|refseq:XP_016885270.1|dip:DIP-33686N|ensembl:ENSG00000130985(gene)|ensembl:ENST00000335972(transcript)|ensembl:ENST00000377351(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0004839"(ubiquitin activating enzyme activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0032446"(protein modification by small protein conjugation)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000011(Ubiquitin-activating enzyme, E1)|interpro:IPR000594(UBA/THIF-type NAD/FAD binding fold)|interpro:IPR018074|interpro:IPR018075|interpro:IPR018965|interpro:IPR019572|interpro:IPR032418|interpro:IPR032420|interpro:IPR033127|interpro:IPR035985|interpro:IPR038252|interpro:IPR042063|interpro:IPR042302|interpro:IPR042449|mint:P22314|rcsb pdb:4P22|rcsb pdb:6DC6|reactome:R-HSA-8866652|reactome:R-HSA-983168	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S3|resulting-ptm:Q92890 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:EwhjYjowkZIAt4UyPcZBUtf9uak10116	rogid:q+vEeA0XLST0Zz173bmEt0dNbDE9606	intact-crc:992F9F2994F56971|rigid:RmF0C13CI/U8+GVNFIzKdPOypM0	false	sufficient binding region:433-481(IPR013083)	his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q62925	uniprotkb:P61088	intact:EBI-636664	intact:EBI-1052908|uniprotkb:Q16781|uniprotkb:Q53Y81|ensembl:ENSP00000316176	psi-mi:m3k1_rat(display_long)|uniprotkb:MAPK/ERK kinase kinase 1(gene name synonym)|uniprotkb:Map3k1(gene name)|psi-mi:Map3k1(display_short)|uniprotkb:Mekk(gene name synonym)|uniprotkb:Mekk1(gene name synonym)	psi-mi:ube2n_human(display_long)|uniprotkb:Ubiquitin-protein ligase N(gene name synonym)|uniprotkb:Ubiquitin carrier protein N(gene name synonym)|uniprotkb:Ubc13(gene name synonym)|uniprotkb:Bendless-like ubiquitin-conjugating enzyme(gene name synonym)|uniprotkb:UBE2N(gene name)|psi-mi:UBE2N(display_short)|uniprotkb:BLU(gene name synonym)|uniprotkb:UbcH13(gene name synonym)|uniprotkb:E2 ubiquitin-conjugating enzyme N(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9972388|imex:IM-22822-109	author-confidence:Z-score = 5.43	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:620966|refseq:NP_446339.1|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR007527(Zinc finger, SWIM-type)|go:"GO:0000165"(MAPK cascade)|interpro:IPR016024(Armadillo-type fold)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0002011"(morphogenesis of an epithelial sheet)|go:"GO:0003382"(epithelial cell morphogenesis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004706"(JUN kinase kinase kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007254"(JNK cascade)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008432"(JUN kinase binding)|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0016020"(membrane)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0031434"(mitogen-activated protein kinase kinase binding)|go:"GO:0031941"(filamentous actin)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0042060"(wound healing)|go:"GO:0043010"(camera-type eye development)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046625"(sphingolipid binding)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050434"(positive regulation of viral transcription)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0061029"(eyelid development in camera-type eye)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|reactome:R-RNO-166058|reactome:R-RNO-2871796|reactome:R-RNO-975138|reactome:R-RNO-975871|interpro:IPR011989(Armadillo-like helical)|mint:Q62925	refseq:NP_003339.1|dip:DIP-29829N|ensembl:ENSG00000177889(gene)|ensembl:ENST00000318066(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000729"(DNA double-strand break processing)|go:"GO:0001650"(fibrillar center)|go:"GO:0003723"(RNA binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006282"(regulation of DNA repair)|go:"GO:0006301"(postreplication repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016574"(histone ubiquitination)|go:"GO:0031058"(positive regulation of histone modification)|go:"GO:0031372"(UBC13-MMS2 complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033182"(regulation of histone ubiquitination)|go:"GO:0035370"(UBC13-UEV1A complex)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0061631"(ubiquitin conjugating enzyme activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070534"(protein K63-linked ubiquitination)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|interpro:IPR023313|rcsb pdb:1J7D|rcsb pdb:2C2V|rcsb pdb:3HCT|rcsb pdb:3HCU|rcsb pdb:3VON|rcsb pdb:3W31|rcsb pdb:4DHI|rcsb pdb:4DHJ|rcsb pdb:4DHZ|rcsb pdb:4IP3|rcsb pdb:4NR3|rcsb pdb:4NRG|rcsb pdb:4NRI|rcsb pdb:4ONL|rcsb pdb:4ONM|rcsb pdb:4ONN|rcsb pdb:4ORH|rcsb pdb:4TKP|rcsb pdb:4WHV|rcsb pdb:5AIT|rcsb pdb:5AIU|rcsb pdb:5EYA|rcsb pdb:5H7S|rcsb pdb:5VNZ|rcsb pdb:5VO0|rcsb pdb:5YWR|rcsb pdb:6D6I|rcsb pdb:6JKY|rcsb pdb:6KFP|rcsb pdb:6KG6|rcsb pdb:6KL4|rcsb pdb:6LP2|rcsb pdb:6P5B|rcsb pdb:6S53|reactome:R-HSA-168927|reactome:R-HSA-202424|reactome:R-HSA-2871837|reactome:R-HSA-445989|reactome:R-HSA-450302|reactome:R-HSA-450321|reactome:R-HSA-5607764|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-5696395|reactome:R-HSA-69473|reactome:R-HSA-8866654|reactome:R-HSA-9020702|reactome:R-HSA-937039|reactome:R-HSA-937041|reactome:R-HSA-9646399|reactome:R-HSA-975110|reactome:R-HSA-975144|reactome:R-HSA-983168|rcsb pdb:6ULH|rcsb pdb:6UMP|rcsb pdb:6UMS|rcsb pdb:7BBD|rcsb pdb:7BBF|rcsb pdb:7BXG|reactome:R-HSA-1169408|reactome:R-HSA-168638	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S3|resulting-ptm:Q92890 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:EwhjYjowkZIAt4UyPcZBUtf9uak10116	rogid:dqdszHlq5FLPHC6UWX6uvkC6Yz89606	intact-crc:992F9F2994F56971|rigid:RmF0C13CI/U8+GVNFIzKdPOypM0	false	sufficient binding region:433-481(IPR013083)	his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q62925	uniprotkb:Q92890	intact:EBI-636664	intact:EBI-1994090|uniprotkb:Q9Y5N0|uniprotkb:A8MW31|ensembl:ENSP00000263202	psi-mi:m3k1_rat(display_long)|uniprotkb:MAPK/ERK kinase kinase 1(gene name synonym)|uniprotkb:Map3k1(gene name)|psi-mi:Map3k1(display_short)|uniprotkb:Mekk(gene name synonym)|uniprotkb:Mekk1(gene name synonym)	psi-mi:ufd1_human(display_long)|uniprotkb:UFD1(gene name)|psi-mi:UFD1(display_short)|uniprotkb:UFD1L(gene name synonym)|uniprotkb:Ubiquitin fusion degradation protein 1(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9972388|imex:IM-22822-109	author-confidence:Z-score = 5.43	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:620966|refseq:NP_446339.1|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR007527(Zinc finger, SWIM-type)|go:"GO:0000165"(MAPK cascade)|interpro:IPR016024(Armadillo-type fold)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0002011"(morphogenesis of an epithelial sheet)|go:"GO:0003382"(epithelial cell morphogenesis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004706"(JUN kinase kinase kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007254"(JNK cascade)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008432"(JUN kinase binding)|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0016020"(membrane)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0031434"(mitogen-activated protein kinase kinase binding)|go:"GO:0031941"(filamentous actin)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0042060"(wound healing)|go:"GO:0043010"(camera-type eye development)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046625"(sphingolipid binding)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050434"(positive regulation of viral transcription)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0061029"(eyelid development in camera-type eye)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|reactome:R-RNO-166058|reactome:R-RNO-2871796|reactome:R-RNO-975138|reactome:R-RNO-975871|interpro:IPR011989(Armadillo-like helical)|mint:Q62925	refseq:NP_005650.2|refseq:NP_001030324.2|dip:DIP-45954N|ensembl:ENSG00000070010(gene)|ensembl:ENST00000263202(transcript)|go:"GO:0001501"(skeletal system development)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030970"(retrograde protein transport, ER to cytosol)|go:"GO:0032480"(negative regulation of type I interferon production)|go:"GO:0034098"(VCP-NPL4-UFD1 AAA ATPase complex)|go:"GO:0036435"(K48-linked polyubiquitin modification-dependent protein binding)|go:"GO:0036501"(UFD1-NPL4 complex)|go:"GO:0039536"(negative regulation of RIG-I signaling pathway)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0051117"(ATPase binding)|go:"GO:0071712"(ER-associated misfolded protein catabolic process)|interpro:IPR004854(Ubiquitin fusion degradation protein UFD1)|interpro:IPR042299|mint:Q92890|rcsb pdb:2YUJ|rcsb pdb:5B6C|rcsb pdb:5C1B|reactome:R-HSA-110320|reactome:R-HSA-5689880|go:"GO:0031593"(polyubiquitin modification-dependent protein binding)	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S3|resulting-ptm:Q92890 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:EwhjYjowkZIAt4UyPcZBUtf9uak10116	rogid:TD7xj2n1cP5JexKMoVg1JfTQArI9606	intact-crc:992F9F2994F56971|rigid:RmF0C13CI/U8+GVNFIzKdPOypM0	false	sufficient binding region:433-481(IPR013083)	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q62925	uniprotkb:Q96B01	intact:EBI-636664	intact:EBI-1178724|uniprotkb:O43403|uniprotkb:Q7Z779|uniprotkb:A8K7D3|ensembl:ENSP00000228843	psi-mi:m3k1_rat(display_long)|uniprotkb:MAPK/ERK kinase kinase 1(gene name synonym)|uniprotkb:Map3k1(gene name)|psi-mi:Map3k1(display_short)|uniprotkb:Mekk(gene name synonym)|uniprotkb:Mekk1(gene name synonym)	psi-mi:r51a1_human(display_long)|uniprotkb:RAD51-interacting protein(gene name synonym)|uniprotkb:RAD51AP1(gene name)|psi-mi:RAD51AP1(display_short)|uniprotkb:PIR51(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9972413|imex:IM-22822-110	author-confidence:Z-score = 4.22	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:620966|refseq:NP_446339.1|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR007527(Zinc finger, SWIM-type)|go:"GO:0000165"(MAPK cascade)|interpro:IPR016024(Armadillo-type fold)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0002011"(morphogenesis of an epithelial sheet)|go:"GO:0003382"(epithelial cell morphogenesis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004706"(JUN kinase kinase kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007254"(JNK cascade)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008432"(JUN kinase binding)|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0016020"(membrane)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0031434"(mitogen-activated protein kinase kinase binding)|go:"GO:0031941"(filamentous actin)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0042060"(wound healing)|go:"GO:0043010"(camera-type eye development)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046625"(sphingolipid binding)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050434"(positive regulation of viral transcription)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0061029"(eyelid development in camera-type eye)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|reactome:R-RNO-166058|reactome:R-RNO-2871796|reactome:R-RNO-975138|reactome:R-RNO-975871|interpro:IPR011989(Armadillo-like helical)|mint:Q62925	refseq:NP_001124334.1|refseq:NP_006470.1|ensembl:ENSG00000111247(gene)|ensembl:ENST00000228843(transcript)|go:"GO:0000217"(DNA secondary structure binding)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000785"(chromatin)|go:"GO:0003677"(DNA binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0006281"(DNA repair)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0010569"(regulation of double-strand break repair via homologous recombination)|go:"GO:0010845"(positive regulation of reciprocal meiotic recombination)|go:"GO:0032991"(protein-containing complex)|go:"GO:0036297"(interstrand cross-link repair)|go:"GO:0051321"(meiotic cell cycle)|go:"GO:0062037"(D-loop DNA binding)|go:"GO:0071479"(cellular response to ionizing radiation)|go:"GO:1905168"(positive regulation of double-strand break repair via homologous recombination)|interpro:IPR026632|interpro:IPR031419|reactome:R-HSA-5685942|reactome:R-HSA-5693554|reactome:R-HSA-5693568|reactome:R-HSA-5693579|dip:DIP-35257N	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S3|resulting-ptm:Q96B01 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:EwhjYjowkZIAt4UyPcZBUtf9uak10116	rogid:5f/zzkdZZSmaPFxkg52s60rDnqQ9606	intact-crc:12185E36ACD7DB67|rigid:lA+Tbrb0DfcgOW9GFQWlR6YIGQ0	false	sufficient binding region:433-481(IPR013083)	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q62925	uniprotkb:Q13404	intact:EBI-636664	intact:EBI-1050671|uniprotkb:Q13403|uniprotkb:Q13532|uniprotkb:Q96H34|uniprotkb:Q9GZT0|uniprotkb:Q9GZW1|uniprotkb:Q9H4J3|uniprotkb:Q9H4J4|uniprotkb:Q9UKL1|uniprotkb:Q9UM48|uniprotkb:Q9UM49|uniprotkb:Q9UM50|uniprotkb:Q5TGE3|uniprotkb:E1P629|uniprotkb:Q5TGE0|ensembl:ENSP00000360739	psi-mi:m3k1_rat(display_long)|uniprotkb:MAPK/ERK kinase kinase 1(gene name synonym)|uniprotkb:Map3k1(gene name)|psi-mi:Map3k1(display_short)|uniprotkb:Mekk(gene name synonym)|uniprotkb:Mekk1(gene name synonym)	psi-mi:ub2v1_human(display_long)|uniprotkb:CROC-1(gene name synonym)|uniprotkb:TRAF6-regulated IKK activator 1 beta Uev1A(gene name synonym)|uniprotkb:P/OKcl.19(orf name)|uniprotkb:UBE2V1(gene name)|psi-mi:UBE2V1(display_short)|uniprotkb:CROC1(gene name synonym)|uniprotkb:UBE2V(gene name synonym)|uniprotkb:UEV1(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9972413|imex:IM-22822-110	author-confidence:Z-score = 4.22	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:620966|refseq:NP_446339.1|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR007527(Zinc finger, SWIM-type)|go:"GO:0000165"(MAPK cascade)|interpro:IPR016024(Armadillo-type fold)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0002011"(morphogenesis of an epithelial sheet)|go:"GO:0003382"(epithelial cell morphogenesis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004706"(JUN kinase kinase kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007254"(JNK cascade)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008432"(JUN kinase binding)|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0016020"(membrane)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0031434"(mitogen-activated protein kinase kinase binding)|go:"GO:0031941"(filamentous actin)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0042060"(wound healing)|go:"GO:0043010"(camera-type eye development)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046625"(sphingolipid binding)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050434"(positive regulation of viral transcription)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0061029"(eyelid development in camera-type eye)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|reactome:R-RNO-166058|reactome:R-RNO-2871796|reactome:R-RNO-975138|reactome:R-RNO-975871|interpro:IPR011989(Armadillo-like helical)|mint:Q62925	refseq:NP_001027459.1|refseq:NP_068823.2|refseq:NP_071887.1|refseq:NP_954595.1|refseq:NP_954673.1|refseq:NP_001244322.1|refseq:NP_001244323.1|refseq:NP_001244325.1|ensembl:ENSG00000244687(gene)|ensembl:ENST00000371674(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006282"(regulation of DNA repair)|go:"GO:0006301"(postreplication repair)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0030154"(cell differentiation)|go:"GO:0031371"(ubiquitin conjugating enzyme complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035370"(UBC13-UEV1A complex)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070534"(protein K63-linked ubiquitination)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|rcsb pdb:2A4D|rcsb pdb:2C2V|rcsb pdb:2HLW|rcsb pdb:6D6I|reactome:R-HSA-168638|reactome:R-HSA-168927|reactome:R-HSA-202424|reactome:R-HSA-2871837|reactome:R-HSA-445989|reactome:R-HSA-450302|reactome:R-HSA-450321|reactome:R-HSA-5607764|reactome:R-HSA-9020702|reactome:R-HSA-937039|reactome:R-HSA-937041|reactome:R-HSA-9646399|reactome:R-HSA-975110|reactome:R-HSA-975144|reactome:R-HSA-983168|dip:DIP-41911N	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S3|resulting-ptm:Q96B01 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:EwhjYjowkZIAt4UyPcZBUtf9uak10116	rogid:x95N7Dj2KIqu5gySX59xLmfthUg9606	intact-crc:12185E36ACD7DB67|rigid:lA+Tbrb0DfcgOW9GFQWlR6YIGQ0	false	sufficient binding region:433-481(IPR013083)	his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q62925	uniprotkb:P22314	intact:EBI-636664	intact:EBI-709688|uniprotkb:Q96E13|uniprotkb:Q5JRR8|ensembl:ENSP00000338413|ensembl:ENSP00000366568	psi-mi:m3k1_rat(display_long)|uniprotkb:MAPK/ERK kinase kinase 1(gene name synonym)|uniprotkb:Map3k1(gene name)|psi-mi:Map3k1(display_short)|uniprotkb:Mekk(gene name synonym)|uniprotkb:Mekk1(gene name synonym)	psi-mi:uba1_human(display_long)|uniprotkb:Ubiquitin-activating enzyme E1(gene name synonym)|uniprotkb:Protein A1S9(gene name synonym)|uniprotkb:UBA1(gene name)|psi-mi:UBA1(display_short)|uniprotkb:A1S9T(gene name synonym)|uniprotkb:UBE1(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9972413|imex:IM-22822-110	author-confidence:Z-score = 4.22	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:620966|refseq:NP_446339.1|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR007527(Zinc finger, SWIM-type)|go:"GO:0000165"(MAPK cascade)|interpro:IPR016024(Armadillo-type fold)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0002011"(morphogenesis of an epithelial sheet)|go:"GO:0003382"(epithelial cell morphogenesis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004706"(JUN kinase kinase kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007254"(JNK cascade)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008432"(JUN kinase binding)|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0016020"(membrane)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0031434"(mitogen-activated protein kinase kinase binding)|go:"GO:0031941"(filamentous actin)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0042060"(wound healing)|go:"GO:0043010"(camera-type eye development)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046625"(sphingolipid binding)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050434"(positive regulation of viral transcription)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0061029"(eyelid development in camera-type eye)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|reactome:R-RNO-166058|reactome:R-RNO-2871796|reactome:R-RNO-975138|reactome:R-RNO-975871|interpro:IPR011989(Armadillo-like helical)|mint:Q62925	refseq:NP_003325.2|refseq:NP_695012.1|refseq:XP_016885269.1|refseq:XP_016885270.1|dip:DIP-33686N|ensembl:ENSG00000130985(gene)|ensembl:ENST00000335972(transcript)|ensembl:ENST00000377351(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0004839"(ubiquitin activating enzyme activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0032446"(protein modification by small protein conjugation)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000011(Ubiquitin-activating enzyme, E1)|interpro:IPR000594(UBA/THIF-type NAD/FAD binding fold)|interpro:IPR018074|interpro:IPR018075|interpro:IPR018965|interpro:IPR019572|interpro:IPR032418|interpro:IPR032420|interpro:IPR033127|interpro:IPR035985|interpro:IPR038252|interpro:IPR042063|interpro:IPR042302|interpro:IPR042449|mint:P22314|rcsb pdb:4P22|rcsb pdb:6DC6|reactome:R-HSA-8866652|reactome:R-HSA-983168	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S3|resulting-ptm:Q96B01 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:EwhjYjowkZIAt4UyPcZBUtf9uak10116	rogid:q+vEeA0XLST0Zz173bmEt0dNbDE9606	intact-crc:12185E36ACD7DB67|rigid:lA+Tbrb0DfcgOW9GFQWlR6YIGQ0	false	sufficient binding region:433-481(IPR013083)	his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q62925	uniprotkb:P61088	intact:EBI-636664	intact:EBI-1052908|uniprotkb:Q16781|uniprotkb:Q53Y81|ensembl:ENSP00000316176	psi-mi:m3k1_rat(display_long)|uniprotkb:MAPK/ERK kinase kinase 1(gene name synonym)|uniprotkb:Map3k1(gene name)|psi-mi:Map3k1(display_short)|uniprotkb:Mekk(gene name synonym)|uniprotkb:Mekk1(gene name synonym)	psi-mi:ube2n_human(display_long)|uniprotkb:Ubiquitin-protein ligase N(gene name synonym)|uniprotkb:Ubiquitin carrier protein N(gene name synonym)|uniprotkb:Ubc13(gene name synonym)|uniprotkb:Bendless-like ubiquitin-conjugating enzyme(gene name synonym)|uniprotkb:UBE2N(gene name)|psi-mi:UBE2N(display_short)|uniprotkb:BLU(gene name synonym)|uniprotkb:UbcH13(gene name synonym)|uniprotkb:E2 ubiquitin-conjugating enzyme N(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9972413|imex:IM-22822-110	author-confidence:Z-score = 4.22	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:620966|refseq:NP_446339.1|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR007527(Zinc finger, SWIM-type)|go:"GO:0000165"(MAPK cascade)|interpro:IPR016024(Armadillo-type fold)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0002011"(morphogenesis of an epithelial sheet)|go:"GO:0003382"(epithelial cell morphogenesis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004706"(JUN kinase kinase kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007254"(JNK cascade)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008432"(JUN kinase binding)|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0016020"(membrane)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0031434"(mitogen-activated protein kinase kinase binding)|go:"GO:0031941"(filamentous actin)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0042060"(wound healing)|go:"GO:0043010"(camera-type eye development)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046625"(sphingolipid binding)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050434"(positive regulation of viral transcription)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0061029"(eyelid development in camera-type eye)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|reactome:R-RNO-166058|reactome:R-RNO-2871796|reactome:R-RNO-975138|reactome:R-RNO-975871|interpro:IPR011989(Armadillo-like helical)|mint:Q62925	refseq:NP_003339.1|dip:DIP-29829N|ensembl:ENSG00000177889(gene)|ensembl:ENST00000318066(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000729"(DNA double-strand break processing)|go:"GO:0001650"(fibrillar center)|go:"GO:0003723"(RNA binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006282"(regulation of DNA repair)|go:"GO:0006301"(postreplication repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016574"(histone ubiquitination)|go:"GO:0031058"(positive regulation of histone modification)|go:"GO:0031372"(UBC13-MMS2 complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033182"(regulation of histone ubiquitination)|go:"GO:0035370"(UBC13-UEV1A complex)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0061631"(ubiquitin conjugating enzyme activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070534"(protein K63-linked ubiquitination)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|interpro:IPR023313|rcsb pdb:1J7D|rcsb pdb:2C2V|rcsb pdb:3HCT|rcsb pdb:3HCU|rcsb pdb:3VON|rcsb pdb:3W31|rcsb pdb:4DHI|rcsb pdb:4DHJ|rcsb pdb:4DHZ|rcsb pdb:4IP3|rcsb pdb:4NR3|rcsb pdb:4NRG|rcsb pdb:4NRI|rcsb pdb:4ONL|rcsb pdb:4ONM|rcsb pdb:4ONN|rcsb pdb:4ORH|rcsb pdb:4TKP|rcsb pdb:4WHV|rcsb pdb:5AIT|rcsb pdb:5AIU|rcsb pdb:5EYA|rcsb pdb:5H7S|rcsb pdb:5VNZ|rcsb pdb:5VO0|rcsb pdb:5YWR|rcsb pdb:6D6I|rcsb pdb:6JKY|rcsb pdb:6KFP|rcsb pdb:6KG6|rcsb pdb:6KL4|rcsb pdb:6LP2|rcsb pdb:6P5B|rcsb pdb:6S53|reactome:R-HSA-168927|reactome:R-HSA-202424|reactome:R-HSA-2871837|reactome:R-HSA-445989|reactome:R-HSA-450302|reactome:R-HSA-450321|reactome:R-HSA-5607764|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-5696395|reactome:R-HSA-69473|reactome:R-HSA-8866654|reactome:R-HSA-9020702|reactome:R-HSA-937039|reactome:R-HSA-937041|reactome:R-HSA-9646399|reactome:R-HSA-975110|reactome:R-HSA-975144|reactome:R-HSA-983168|rcsb pdb:6ULH|rcsb pdb:6UMP|rcsb pdb:6UMS|rcsb pdb:7BBD|rcsb pdb:7BBF|rcsb pdb:7BXG|reactome:R-HSA-1169408|reactome:R-HSA-168638	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S3|resulting-ptm:Q96B01 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:EwhjYjowkZIAt4UyPcZBUtf9uak10116	rogid:dqdszHlq5FLPHC6UWX6uvkC6Yz89606	intact-crc:12185E36ACD7DB67|rigid:lA+Tbrb0DfcgOW9GFQWlR6YIGQ0	false	sufficient binding region:433-481(IPR013083)	his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q96CS3	uniprotkb:Q62925	intact:EBI-1055805|uniprotkb:O94963|uniprotkb:Q8IUF2|uniprotkb:Q9BRP2|uniprotkb:Q9BVM7|ensembl:ENSP00000261942	intact:EBI-636664	psi-mi:faf2_human(display_long)|uniprotkb:Protein ETEA(gene name synonym)|uniprotkb:FAF2(gene name)|psi-mi:FAF2(display_short)|uniprotkb:ETEA(gene name synonym)|uniprotkb:KIAA0887(gene name synonym)|uniprotkb:UBXD8(gene name synonym)|uniprotkb:UBXN3B(gene name synonym)|uniprotkb:UBX domain-containing protein 3B(gene name synonym)|uniprotkb:UBX domain-containing protein 8(gene name synonym)	psi-mi:m3k1_rat(display_long)|uniprotkb:MAPK/ERK kinase kinase 1(gene name synonym)|uniprotkb:Map3k1(gene name)|psi-mi:Map3k1(display_short)|uniprotkb:Mekk(gene name synonym)|uniprotkb:Mekk1(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9972438|imex:IM-22822-111	author-confidence:Z-score = 6.04	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_055428.1|ensembl:ENSP00000261942|ensembl:ENST00000261942(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005811"(lipid droplet)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030970"(retrograde protein transport, ER to cytosol)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0034098"(VCP-NPL4-UFD1 AAA ATPase complex)|go:"GO:0034389"(lipid droplet organization)|go:"GO:0035473"(lipase binding)|go:"GO:0035578"(azurophil granule lumen)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0055102"(lipase inhibitor activity)|interpro:IPR001012(UBX)|interpro:IPR006577(UAS)|interpro:IPR009060(UBA-like)|interpro:IPR029071|interpro:IPR036249|mint:Q96CS3|rcsb pdb:2DAM|reactome:R-HSA-6798695|reactome:R-HSA-8980692|ensembl:ENSG00000113194(gene)|dip:DIP-46261N	rgd:620966|refseq:NP_446339.1|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR007527(Zinc finger, SWIM-type)|go:"GO:0000165"(MAPK cascade)|interpro:IPR016024(Armadillo-type fold)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0002011"(morphogenesis of an epithelial sheet)|go:"GO:0003382"(epithelial cell morphogenesis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004706"(JUN kinase kinase kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007254"(JNK cascade)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008432"(JUN kinase binding)|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0016020"(membrane)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0031434"(mitogen-activated protein kinase kinase binding)|go:"GO:0031941"(filamentous actin)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0042060"(wound healing)|go:"GO:0043010"(camera-type eye development)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046625"(sphingolipid binding)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050434"(positive regulation of viral transcription)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0061029"(eyelid development in camera-type eye)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|reactome:R-RNO-166058|reactome:R-RNO-2871796|reactome:R-RNO-975138|reactome:R-RNO-975871|interpro:IPR011989(Armadillo-like helical)|mint:Q62925	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S3|resulting-ptm:Q96CS3 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:GCm7BqDpwxDW1iABu0cShmWHtZQ9606	rogid:EwhjYjowkZIAt4UyPcZBUtf9uak10116	intact-crc:1F0A48BD3E81801F|rigid:eOBSKe0uylVKyePGBGaiva54aeE	false	-	sufficient binding region:433-481(IPR013083)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q96CS3	uniprotkb:Q13404	intact:EBI-1055805|uniprotkb:O94963|uniprotkb:Q8IUF2|uniprotkb:Q9BRP2|uniprotkb:Q9BVM7|ensembl:ENSP00000261942	intact:EBI-1050671|uniprotkb:Q13403|uniprotkb:Q13532|uniprotkb:Q96H34|uniprotkb:Q9GZT0|uniprotkb:Q9GZW1|uniprotkb:Q9H4J3|uniprotkb:Q9H4J4|uniprotkb:Q9UKL1|uniprotkb:Q9UM48|uniprotkb:Q9UM49|uniprotkb:Q9UM50|uniprotkb:Q5TGE3|uniprotkb:E1P629|uniprotkb:Q5TGE0|ensembl:ENSP00000360739	psi-mi:faf2_human(display_long)|uniprotkb:Protein ETEA(gene name synonym)|uniprotkb:FAF2(gene name)|psi-mi:FAF2(display_short)|uniprotkb:ETEA(gene name synonym)|uniprotkb:KIAA0887(gene name synonym)|uniprotkb:UBXD8(gene name synonym)|uniprotkb:UBXN3B(gene name synonym)|uniprotkb:UBX domain-containing protein 3B(gene name synonym)|uniprotkb:UBX domain-containing protein 8(gene name synonym)	psi-mi:ub2v1_human(display_long)|uniprotkb:CROC-1(gene name synonym)|uniprotkb:TRAF6-regulated IKK activator 1 beta Uev1A(gene name synonym)|uniprotkb:P/OKcl.19(orf name)|uniprotkb:UBE2V1(gene name)|psi-mi:UBE2V1(display_short)|uniprotkb:CROC1(gene name synonym)|uniprotkb:UBE2V(gene name synonym)|uniprotkb:UEV1(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9972438|imex:IM-22822-111	author-confidence:Z-score = 6.04	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_055428.1|ensembl:ENSP00000261942|ensembl:ENST00000261942(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005811"(lipid droplet)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030970"(retrograde protein transport, ER to cytosol)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0034098"(VCP-NPL4-UFD1 AAA ATPase complex)|go:"GO:0034389"(lipid droplet organization)|go:"GO:0035473"(lipase binding)|go:"GO:0035578"(azurophil granule lumen)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0055102"(lipase inhibitor activity)|interpro:IPR001012(UBX)|interpro:IPR006577(UAS)|interpro:IPR009060(UBA-like)|interpro:IPR029071|interpro:IPR036249|mint:Q96CS3|rcsb pdb:2DAM|reactome:R-HSA-6798695|reactome:R-HSA-8980692|ensembl:ENSG00000113194(gene)|dip:DIP-46261N	refseq:NP_001027459.1|refseq:NP_068823.2|refseq:NP_071887.1|refseq:NP_954595.1|refseq:NP_954673.1|refseq:NP_001244322.1|refseq:NP_001244323.1|refseq:NP_001244325.1|ensembl:ENSG00000244687(gene)|ensembl:ENST00000371674(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006282"(regulation of DNA repair)|go:"GO:0006301"(postreplication repair)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0030154"(cell differentiation)|go:"GO:0031371"(ubiquitin conjugating enzyme complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035370"(UBC13-UEV1A complex)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070534"(protein K63-linked ubiquitination)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|rcsb pdb:2A4D|rcsb pdb:2C2V|rcsb pdb:2HLW|rcsb pdb:6D6I|reactome:R-HSA-168638|reactome:R-HSA-168927|reactome:R-HSA-202424|reactome:R-HSA-2871837|reactome:R-HSA-445989|reactome:R-HSA-450302|reactome:R-HSA-450321|reactome:R-HSA-5607764|reactome:R-HSA-9020702|reactome:R-HSA-937039|reactome:R-HSA-937041|reactome:R-HSA-9646399|reactome:R-HSA-975110|reactome:R-HSA-975144|reactome:R-HSA-983168|dip:DIP-41911N	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S3|resulting-ptm:Q96CS3 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:GCm7BqDpwxDW1iABu0cShmWHtZQ9606	rogid:x95N7Dj2KIqu5gySX59xLmfthUg9606	intact-crc:1F0A48BD3E81801F|rigid:eOBSKe0uylVKyePGBGaiva54aeE	false	-	his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q96CS3	uniprotkb:P22314	intact:EBI-1055805|uniprotkb:O94963|uniprotkb:Q8IUF2|uniprotkb:Q9BRP2|uniprotkb:Q9BVM7|ensembl:ENSP00000261942	intact:EBI-709688|uniprotkb:Q96E13|uniprotkb:Q5JRR8|ensembl:ENSP00000338413|ensembl:ENSP00000366568	psi-mi:faf2_human(display_long)|uniprotkb:Protein ETEA(gene name synonym)|uniprotkb:FAF2(gene name)|psi-mi:FAF2(display_short)|uniprotkb:ETEA(gene name synonym)|uniprotkb:KIAA0887(gene name synonym)|uniprotkb:UBXD8(gene name synonym)|uniprotkb:UBXN3B(gene name synonym)|uniprotkb:UBX domain-containing protein 3B(gene name synonym)|uniprotkb:UBX domain-containing protein 8(gene name synonym)	psi-mi:uba1_human(display_long)|uniprotkb:Ubiquitin-activating enzyme E1(gene name synonym)|uniprotkb:Protein A1S9(gene name synonym)|uniprotkb:UBA1(gene name)|psi-mi:UBA1(display_short)|uniprotkb:A1S9T(gene name synonym)|uniprotkb:UBE1(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9972438|imex:IM-22822-111	author-confidence:Z-score = 6.04	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_055428.1|ensembl:ENSP00000261942|ensembl:ENST00000261942(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005811"(lipid droplet)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030970"(retrograde protein transport, ER to cytosol)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0034098"(VCP-NPL4-UFD1 AAA ATPase complex)|go:"GO:0034389"(lipid droplet organization)|go:"GO:0035473"(lipase binding)|go:"GO:0035578"(azurophil granule lumen)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0055102"(lipase inhibitor activity)|interpro:IPR001012(UBX)|interpro:IPR006577(UAS)|interpro:IPR009060(UBA-like)|interpro:IPR029071|interpro:IPR036249|mint:Q96CS3|rcsb pdb:2DAM|reactome:R-HSA-6798695|reactome:R-HSA-8980692|ensembl:ENSG00000113194(gene)|dip:DIP-46261N	refseq:NP_003325.2|refseq:NP_695012.1|refseq:XP_016885269.1|refseq:XP_016885270.1|dip:DIP-33686N|ensembl:ENSG00000130985(gene)|ensembl:ENST00000335972(transcript)|ensembl:ENST00000377351(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0004839"(ubiquitin activating enzyme activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0032446"(protein modification by small protein conjugation)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000011(Ubiquitin-activating enzyme, E1)|interpro:IPR000594(UBA/THIF-type NAD/FAD binding fold)|interpro:IPR018074|interpro:IPR018075|interpro:IPR018965|interpro:IPR019572|interpro:IPR032418|interpro:IPR032420|interpro:IPR033127|interpro:IPR035985|interpro:IPR038252|interpro:IPR042063|interpro:IPR042302|interpro:IPR042449|mint:P22314|rcsb pdb:4P22|rcsb pdb:6DC6|reactome:R-HSA-8866652|reactome:R-HSA-983168	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S3|resulting-ptm:Q96CS3 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:GCm7BqDpwxDW1iABu0cShmWHtZQ9606	rogid:q+vEeA0XLST0Zz173bmEt0dNbDE9606	intact-crc:1F0A48BD3E81801F|rigid:eOBSKe0uylVKyePGBGaiva54aeE	false	-	his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q96CS3	uniprotkb:P61088	intact:EBI-1055805|uniprotkb:O94963|uniprotkb:Q8IUF2|uniprotkb:Q9BRP2|uniprotkb:Q9BVM7|ensembl:ENSP00000261942	intact:EBI-1052908|uniprotkb:Q16781|uniprotkb:Q53Y81|ensembl:ENSP00000316176	psi-mi:faf2_human(display_long)|uniprotkb:Protein ETEA(gene name synonym)|uniprotkb:FAF2(gene name)|psi-mi:FAF2(display_short)|uniprotkb:ETEA(gene name synonym)|uniprotkb:KIAA0887(gene name synonym)|uniprotkb:UBXD8(gene name synonym)|uniprotkb:UBXN3B(gene name synonym)|uniprotkb:UBX domain-containing protein 3B(gene name synonym)|uniprotkb:UBX domain-containing protein 8(gene name synonym)	psi-mi:ube2n_human(display_long)|uniprotkb:Ubiquitin-protein ligase N(gene name synonym)|uniprotkb:Ubiquitin carrier protein N(gene name synonym)|uniprotkb:Ubc13(gene name synonym)|uniprotkb:Bendless-like ubiquitin-conjugating enzyme(gene name synonym)|uniprotkb:UBE2N(gene name)|psi-mi:UBE2N(display_short)|uniprotkb:BLU(gene name synonym)|uniprotkb:UbcH13(gene name synonym)|uniprotkb:E2 ubiquitin-conjugating enzyme N(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9972438|imex:IM-22822-111	author-confidence:Z-score = 6.04	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_055428.1|ensembl:ENSP00000261942|ensembl:ENST00000261942(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005811"(lipid droplet)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030970"(retrograde protein transport, ER to cytosol)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0034098"(VCP-NPL4-UFD1 AAA ATPase complex)|go:"GO:0034389"(lipid droplet organization)|go:"GO:0035473"(lipase binding)|go:"GO:0035578"(azurophil granule lumen)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0055102"(lipase inhibitor activity)|interpro:IPR001012(UBX)|interpro:IPR006577(UAS)|interpro:IPR009060(UBA-like)|interpro:IPR029071|interpro:IPR036249|mint:Q96CS3|rcsb pdb:2DAM|reactome:R-HSA-6798695|reactome:R-HSA-8980692|ensembl:ENSG00000113194(gene)|dip:DIP-46261N	refseq:NP_003339.1|dip:DIP-29829N|ensembl:ENSG00000177889(gene)|ensembl:ENST00000318066(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000729"(DNA double-strand break processing)|go:"GO:0001650"(fibrillar center)|go:"GO:0003723"(RNA binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006282"(regulation of DNA repair)|go:"GO:0006301"(postreplication repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016574"(histone ubiquitination)|go:"GO:0031058"(positive regulation of histone modification)|go:"GO:0031372"(UBC13-MMS2 complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033182"(regulation of histone ubiquitination)|go:"GO:0035370"(UBC13-UEV1A complex)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0061631"(ubiquitin conjugating enzyme activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070534"(protein K63-linked ubiquitination)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|interpro:IPR023313|rcsb pdb:1J7D|rcsb pdb:2C2V|rcsb pdb:3HCT|rcsb pdb:3HCU|rcsb pdb:3VON|rcsb pdb:3W31|rcsb pdb:4DHI|rcsb pdb:4DHJ|rcsb pdb:4DHZ|rcsb pdb:4IP3|rcsb pdb:4NR3|rcsb pdb:4NRG|rcsb pdb:4NRI|rcsb pdb:4ONL|rcsb pdb:4ONM|rcsb pdb:4ONN|rcsb pdb:4ORH|rcsb pdb:4TKP|rcsb pdb:4WHV|rcsb pdb:5AIT|rcsb pdb:5AIU|rcsb pdb:5EYA|rcsb pdb:5H7S|rcsb pdb:5VNZ|rcsb pdb:5VO0|rcsb pdb:5YWR|rcsb pdb:6D6I|rcsb pdb:6JKY|rcsb pdb:6KFP|rcsb pdb:6KG6|rcsb pdb:6KL4|rcsb pdb:6LP2|rcsb pdb:6P5B|rcsb pdb:6S53|reactome:R-HSA-168927|reactome:R-HSA-202424|reactome:R-HSA-2871837|reactome:R-HSA-445989|reactome:R-HSA-450302|reactome:R-HSA-450321|reactome:R-HSA-5607764|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-5696395|reactome:R-HSA-69473|reactome:R-HSA-8866654|reactome:R-HSA-9020702|reactome:R-HSA-937039|reactome:R-HSA-937041|reactome:R-HSA-9646399|reactome:R-HSA-975110|reactome:R-HSA-975144|reactome:R-HSA-983168|rcsb pdb:6ULH|rcsb pdb:6UMP|rcsb pdb:6UMS|rcsb pdb:7BBD|rcsb pdb:7BBF|rcsb pdb:7BXG|reactome:R-HSA-1169408|reactome:R-HSA-168638	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S3|resulting-ptm:Q96CS3 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:GCm7BqDpwxDW1iABu0cShmWHtZQ9606	rogid:dqdszHlq5FLPHC6UWX6uvkC6Yz89606	intact-crc:1F0A48BD3E81801F|rigid:eOBSKe0uylVKyePGBGaiva54aeE	false	-	his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q62925	uniprotkb:Q96CS7	intact:EBI-636664	intact:EBI-373552|uniprotkb:Q53TH7|uniprotkb:Q86W37|uniprotkb:Q9BV75|uniprotkb:Q9NWK1|uniprotkb:Q53FF1|uniprotkb:B8ZZN1|uniprotkb:B4DF08|uniprotkb:B4DZ66|ensembl:ENSP00000386662|ensembl:ENSP00000386666	psi-mi:m3k1_rat(display_long)|uniprotkb:MAPK/ERK kinase kinase 1(gene name synonym)|uniprotkb:Map3k1(gene name)|psi-mi:Map3k1(display_short)|uniprotkb:Mekk(gene name synonym)|uniprotkb:Mekk1(gene name synonym)	psi-mi:pkhb2_human(display_long)|uniprotkb:PLEKHB2(gene name)|psi-mi:PLEKHB2(display_short)|uniprotkb:EVT2(gene name synonym)|uniprotkb:Evectin-2(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9972463|imex:IM-22822-112	author-confidence:Z-score = 4.23	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:620966|refseq:NP_446339.1|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR007527(Zinc finger, SWIM-type)|go:"GO:0000165"(MAPK cascade)|interpro:IPR016024(Armadillo-type fold)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0002011"(morphogenesis of an epithelial sheet)|go:"GO:0003382"(epithelial cell morphogenesis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004706"(JUN kinase kinase kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007254"(JNK cascade)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008432"(JUN kinase binding)|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0016020"(membrane)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0031434"(mitogen-activated protein kinase kinase binding)|go:"GO:0031941"(filamentous actin)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0042060"(wound healing)|go:"GO:0043010"(camera-type eye development)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046625"(sphingolipid binding)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050434"(positive regulation of viral transcription)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0061029"(eyelid development in camera-type eye)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|reactome:R-RNO-166058|reactome:R-RNO-2871796|reactome:R-RNO-975138|reactome:R-RNO-975871|interpro:IPR011989(Armadillo-like helical)|mint:Q62925	refseq:NP_001296377.1|refseq:NP_001296379.1|refseq:NP_001296380.1|refseq:NP_001296381.1|refseq:NP_001094093.1|refseq:NP_060428.2|refseq:NP_001253991.1|refseq:NP_001253992.1|refseq:NP_001253993.1|refseq:NP_001253994.1|refseq:NP_001253995.1|refseq:NP_001253996.1|refseq:NP_001253997.1|refseq:XP_016859900.1|refseq:XP_016859901.1|ensembl:ENSG00000115762(gene)|ensembl:ENST00000409279(transcript)|ensembl:ENST00000409612(transcript)|go:"GO:0005547"(phosphatidylinositol-3,4,5-trisphosphate binding)|go:"GO:0016021"(integral component of membrane)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0055038"(recycling endosome membrane)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR039680|interpro:IPR039815|rcsb pdb:3AJ4|rcsb pdb:3VIA	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S3|resulting-ptm:Q96CS7 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:EwhjYjowkZIAt4UyPcZBUtf9uak10116	rogid:m2csf4ODNOWiaXzaJAuMwQxTCS49606	intact-crc:B28B58FA13057998|rigid:Fs7hmpcxNOD5Kcfq5VxYdCjye60	false	sufficient binding region:433-481(IPR013083)	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q62925	uniprotkb:Q13404	intact:EBI-636664	intact:EBI-1050671|uniprotkb:Q13403|uniprotkb:Q13532|uniprotkb:Q96H34|uniprotkb:Q9GZT0|uniprotkb:Q9GZW1|uniprotkb:Q9H4J3|uniprotkb:Q9H4J4|uniprotkb:Q9UKL1|uniprotkb:Q9UM48|uniprotkb:Q9UM49|uniprotkb:Q9UM50|uniprotkb:Q5TGE3|uniprotkb:E1P629|uniprotkb:Q5TGE0|ensembl:ENSP00000360739	psi-mi:m3k1_rat(display_long)|uniprotkb:MAPK/ERK kinase kinase 1(gene name synonym)|uniprotkb:Map3k1(gene name)|psi-mi:Map3k1(display_short)|uniprotkb:Mekk(gene name synonym)|uniprotkb:Mekk1(gene name synonym)	psi-mi:ub2v1_human(display_long)|uniprotkb:CROC-1(gene name synonym)|uniprotkb:TRAF6-regulated IKK activator 1 beta Uev1A(gene name synonym)|uniprotkb:P/OKcl.19(orf name)|uniprotkb:UBE2V1(gene name)|psi-mi:UBE2V1(display_short)|uniprotkb:CROC1(gene name synonym)|uniprotkb:UBE2V(gene name synonym)|uniprotkb:UEV1(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9972463|imex:IM-22822-112	author-confidence:Z-score = 4.23	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:620966|refseq:NP_446339.1|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR007527(Zinc finger, SWIM-type)|go:"GO:0000165"(MAPK cascade)|interpro:IPR016024(Armadillo-type fold)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0002011"(morphogenesis of an epithelial sheet)|go:"GO:0003382"(epithelial cell morphogenesis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004706"(JUN kinase kinase kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007254"(JNK cascade)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008432"(JUN kinase binding)|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0016020"(membrane)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0031434"(mitogen-activated protein kinase kinase binding)|go:"GO:0031941"(filamentous actin)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0042060"(wound healing)|go:"GO:0043010"(camera-type eye development)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046625"(sphingolipid binding)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050434"(positive regulation of viral transcription)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0061029"(eyelid development in camera-type eye)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|reactome:R-RNO-166058|reactome:R-RNO-2871796|reactome:R-RNO-975138|reactome:R-RNO-975871|interpro:IPR011989(Armadillo-like helical)|mint:Q62925	refseq:NP_001027459.1|refseq:NP_068823.2|refseq:NP_071887.1|refseq:NP_954595.1|refseq:NP_954673.1|refseq:NP_001244322.1|refseq:NP_001244323.1|refseq:NP_001244325.1|ensembl:ENSG00000244687(gene)|ensembl:ENST00000371674(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006282"(regulation of DNA repair)|go:"GO:0006301"(postreplication repair)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0030154"(cell differentiation)|go:"GO:0031371"(ubiquitin conjugating enzyme complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035370"(UBC13-UEV1A complex)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070534"(protein K63-linked ubiquitination)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|rcsb pdb:2A4D|rcsb pdb:2C2V|rcsb pdb:2HLW|rcsb pdb:6D6I|reactome:R-HSA-168638|reactome:R-HSA-168927|reactome:R-HSA-202424|reactome:R-HSA-2871837|reactome:R-HSA-445989|reactome:R-HSA-450302|reactome:R-HSA-450321|reactome:R-HSA-5607764|reactome:R-HSA-9020702|reactome:R-HSA-937039|reactome:R-HSA-937041|reactome:R-HSA-9646399|reactome:R-HSA-975110|reactome:R-HSA-975144|reactome:R-HSA-983168|dip:DIP-41911N	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S3|resulting-ptm:Q96CS7 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:EwhjYjowkZIAt4UyPcZBUtf9uak10116	rogid:x95N7Dj2KIqu5gySX59xLmfthUg9606	intact-crc:B28B58FA13057998|rigid:Fs7hmpcxNOD5Kcfq5VxYdCjye60	false	sufficient binding region:433-481(IPR013083)	his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q62925	uniprotkb:P22314	intact:EBI-636664	intact:EBI-709688|uniprotkb:Q96E13|uniprotkb:Q5JRR8|ensembl:ENSP00000338413|ensembl:ENSP00000366568	psi-mi:m3k1_rat(display_long)|uniprotkb:MAPK/ERK kinase kinase 1(gene name synonym)|uniprotkb:Map3k1(gene name)|psi-mi:Map3k1(display_short)|uniprotkb:Mekk(gene name synonym)|uniprotkb:Mekk1(gene name synonym)	psi-mi:uba1_human(display_long)|uniprotkb:Ubiquitin-activating enzyme E1(gene name synonym)|uniprotkb:Protein A1S9(gene name synonym)|uniprotkb:UBA1(gene name)|psi-mi:UBA1(display_short)|uniprotkb:A1S9T(gene name synonym)|uniprotkb:UBE1(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9972463|imex:IM-22822-112	author-confidence:Z-score = 4.23	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:620966|refseq:NP_446339.1|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR007527(Zinc finger, SWIM-type)|go:"GO:0000165"(MAPK cascade)|interpro:IPR016024(Armadillo-type fold)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0002011"(morphogenesis of an epithelial sheet)|go:"GO:0003382"(epithelial cell morphogenesis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004706"(JUN kinase kinase kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007254"(JNK cascade)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008432"(JUN kinase binding)|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0016020"(membrane)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0031434"(mitogen-activated protein kinase kinase binding)|go:"GO:0031941"(filamentous actin)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0042060"(wound healing)|go:"GO:0043010"(camera-type eye development)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046625"(sphingolipid binding)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050434"(positive regulation of viral transcription)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0061029"(eyelid development in camera-type eye)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|reactome:R-RNO-166058|reactome:R-RNO-2871796|reactome:R-RNO-975138|reactome:R-RNO-975871|interpro:IPR011989(Armadillo-like helical)|mint:Q62925	refseq:NP_003325.2|refseq:NP_695012.1|refseq:XP_016885269.1|refseq:XP_016885270.1|dip:DIP-33686N|ensembl:ENSG00000130985(gene)|ensembl:ENST00000335972(transcript)|ensembl:ENST00000377351(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0004839"(ubiquitin activating enzyme activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0032446"(protein modification by small protein conjugation)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000011(Ubiquitin-activating enzyme, E1)|interpro:IPR000594(UBA/THIF-type NAD/FAD binding fold)|interpro:IPR018074|interpro:IPR018075|interpro:IPR018965|interpro:IPR019572|interpro:IPR032418|interpro:IPR032420|interpro:IPR033127|interpro:IPR035985|interpro:IPR038252|interpro:IPR042063|interpro:IPR042302|interpro:IPR042449|mint:P22314|rcsb pdb:4P22|rcsb pdb:6DC6|reactome:R-HSA-8866652|reactome:R-HSA-983168	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S3|resulting-ptm:Q96CS7 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:EwhjYjowkZIAt4UyPcZBUtf9uak10116	rogid:q+vEeA0XLST0Zz173bmEt0dNbDE9606	intact-crc:B28B58FA13057998|rigid:Fs7hmpcxNOD5Kcfq5VxYdCjye60	false	sufficient binding region:433-481(IPR013083)	his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q62925	uniprotkb:P61088	intact:EBI-636664	intact:EBI-1052908|uniprotkb:Q16781|uniprotkb:Q53Y81|ensembl:ENSP00000316176	psi-mi:m3k1_rat(display_long)|uniprotkb:MAPK/ERK kinase kinase 1(gene name synonym)|uniprotkb:Map3k1(gene name)|psi-mi:Map3k1(display_short)|uniprotkb:Mekk(gene name synonym)|uniprotkb:Mekk1(gene name synonym)	psi-mi:ube2n_human(display_long)|uniprotkb:Ubiquitin-protein ligase N(gene name synonym)|uniprotkb:Ubiquitin carrier protein N(gene name synonym)|uniprotkb:Ubc13(gene name synonym)|uniprotkb:Bendless-like ubiquitin-conjugating enzyme(gene name synonym)|uniprotkb:UBE2N(gene name)|psi-mi:UBE2N(display_short)|uniprotkb:BLU(gene name synonym)|uniprotkb:UbcH13(gene name synonym)|uniprotkb:E2 ubiquitin-conjugating enzyme N(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9972463|imex:IM-22822-112	author-confidence:Z-score = 4.23	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:620966|refseq:NP_446339.1|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR007527(Zinc finger, SWIM-type)|go:"GO:0000165"(MAPK cascade)|interpro:IPR016024(Armadillo-type fold)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0002011"(morphogenesis of an epithelial sheet)|go:"GO:0003382"(epithelial cell morphogenesis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004706"(JUN kinase kinase kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007254"(JNK cascade)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008432"(JUN kinase binding)|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0016020"(membrane)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0031434"(mitogen-activated protein kinase kinase binding)|go:"GO:0031941"(filamentous actin)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0042060"(wound healing)|go:"GO:0043010"(camera-type eye development)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046625"(sphingolipid binding)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050434"(positive regulation of viral transcription)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0061029"(eyelid development in camera-type eye)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|reactome:R-RNO-166058|reactome:R-RNO-2871796|reactome:R-RNO-975138|reactome:R-RNO-975871|interpro:IPR011989(Armadillo-like helical)|mint:Q62925	refseq:NP_003339.1|dip:DIP-29829N|ensembl:ENSG00000177889(gene)|ensembl:ENST00000318066(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000729"(DNA double-strand break processing)|go:"GO:0001650"(fibrillar center)|go:"GO:0003723"(RNA binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006282"(regulation of DNA repair)|go:"GO:0006301"(postreplication repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016574"(histone ubiquitination)|go:"GO:0031058"(positive regulation of histone modification)|go:"GO:0031372"(UBC13-MMS2 complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033182"(regulation of histone ubiquitination)|go:"GO:0035370"(UBC13-UEV1A complex)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0061631"(ubiquitin conjugating enzyme activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070534"(protein K63-linked ubiquitination)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|interpro:IPR023313|rcsb pdb:1J7D|rcsb pdb:2C2V|rcsb pdb:3HCT|rcsb pdb:3HCU|rcsb pdb:3VON|rcsb pdb:3W31|rcsb pdb:4DHI|rcsb pdb:4DHJ|rcsb pdb:4DHZ|rcsb pdb:4IP3|rcsb pdb:4NR3|rcsb pdb:4NRG|rcsb pdb:4NRI|rcsb pdb:4ONL|rcsb pdb:4ONM|rcsb pdb:4ONN|rcsb pdb:4ORH|rcsb pdb:4TKP|rcsb pdb:4WHV|rcsb pdb:5AIT|rcsb pdb:5AIU|rcsb pdb:5EYA|rcsb pdb:5H7S|rcsb pdb:5VNZ|rcsb pdb:5VO0|rcsb pdb:5YWR|rcsb pdb:6D6I|rcsb pdb:6JKY|rcsb pdb:6KFP|rcsb pdb:6KG6|rcsb pdb:6KL4|rcsb pdb:6LP2|rcsb pdb:6P5B|rcsb pdb:6S53|reactome:R-HSA-168927|reactome:R-HSA-202424|reactome:R-HSA-2871837|reactome:R-HSA-445989|reactome:R-HSA-450302|reactome:R-HSA-450321|reactome:R-HSA-5607764|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-5696395|reactome:R-HSA-69473|reactome:R-HSA-8866654|reactome:R-HSA-9020702|reactome:R-HSA-937039|reactome:R-HSA-937041|reactome:R-HSA-9646399|reactome:R-HSA-975110|reactome:R-HSA-975144|reactome:R-HSA-983168|rcsb pdb:6ULH|rcsb pdb:6UMP|rcsb pdb:6UMS|rcsb pdb:7BBD|rcsb pdb:7BBF|rcsb pdb:7BXG|reactome:R-HSA-1169408|reactome:R-HSA-168638	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S3|resulting-ptm:Q96CS7 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:EwhjYjowkZIAt4UyPcZBUtf9uak10116	rogid:dqdszHlq5FLPHC6UWX6uvkC6Yz89606	intact-crc:B28B58FA13057998|rigid:Fs7hmpcxNOD5Kcfq5VxYdCjye60	false	sufficient binding region:433-481(IPR013083)	his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q96HD1	uniprotkb:Q62925	intact:EBI-713009|uniprotkb:Q6I9X5|uniprotkb:Q8NFT4|uniprotkb:Q9Y409|uniprotkb:A8MX90|uniprotkb:B2RAA9|ensembl:ENSP00000373322|ensembl:ENSP00000393643|ensembl:ENSP00000507127|ensembl:ENSP00000508358	intact:EBI-636664	psi-mi:crel1_human(display_long)|uniprotkb:CRELD1(gene name)|psi-mi:CRELD1(display_short)|uniprotkb:CIRRIN(gene name synonym)|uniprotkb:Cysteine-rich with EGF-like domain protein 1(gene name synonym)|uniprotkb:UNQ188/PRO214(orf name)	psi-mi:m3k1_rat(display_long)|uniprotkb:MAPK/ERK kinase kinase 1(gene name synonym)|uniprotkb:Map3k1(gene name)|psi-mi:Map3k1(display_short)|uniprotkb:Mekk(gene name synonym)|uniprotkb:Mekk1(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9972513|imex:IM-22822-114	author-confidence:Z-score = 6.25	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001026887.1|refseq:NP_001070883.1|refseq:NP_056328.2|refseq:XP_016862664.1|ensembl:ENSG00000163703(gene)|ensembl:ENST00000383811(transcript)|ensembl:ENST00000452070(transcript)|ensembl:ENST00000682783(transcript)|ensembl:ENST00000684493(transcript)|go:"GO:0003197"(endocardial cushion development)|go:"GO:0003279"(cardiac septum development)|go:"GO:0003756"(protein disulfide isomerase activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0016021"(integral component of membrane)|go:"GO:0062023"(collagen-containing extracellular matrix)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR002049(EGF-like, laminin)|interpro:IPR006212(Furin-like repeat)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR018097|interpro:IPR021852|mint:Q96HD1	rgd:620966|refseq:NP_446339.1|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR007527(Zinc finger, SWIM-type)|go:"GO:0000165"(MAPK cascade)|interpro:IPR016024(Armadillo-type fold)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0002011"(morphogenesis of an epithelial sheet)|go:"GO:0003382"(epithelial cell morphogenesis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004706"(JUN kinase kinase kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007254"(JNK cascade)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008432"(JUN kinase binding)|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0016020"(membrane)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0031434"(mitogen-activated protein kinase kinase binding)|go:"GO:0031941"(filamentous actin)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0042060"(wound healing)|go:"GO:0043010"(camera-type eye development)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046625"(sphingolipid binding)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050434"(positive regulation of viral transcription)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0061029"(eyelid development in camera-type eye)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|reactome:R-RNO-166058|reactome:R-RNO-2871796|reactome:R-RNO-975138|reactome:R-RNO-975871|interpro:IPR011989(Armadillo-like helical)|mint:Q62925	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S3|resulting-ptm:Q96HD1 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:YCHTMCBYRLSWAJ4W+2lmt/EjUlQ9606	rogid:EwhjYjowkZIAt4UyPcZBUtf9uak10116	intact-crc:46A4EFA12D39CE2B|rigid:C+Hrxtw9LjsEt15/weNAOQ1SZMk	false	-	sufficient binding region:433-481(IPR013083)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q96HD1	uniprotkb:Q13404	intact:EBI-713009|uniprotkb:Q6I9X5|uniprotkb:Q8NFT4|uniprotkb:Q9Y409|uniprotkb:A8MX90|uniprotkb:B2RAA9|ensembl:ENSP00000373322|ensembl:ENSP00000393643|ensembl:ENSP00000507127|ensembl:ENSP00000508358	intact:EBI-1050671|uniprotkb:Q13403|uniprotkb:Q13532|uniprotkb:Q96H34|uniprotkb:Q9GZT0|uniprotkb:Q9GZW1|uniprotkb:Q9H4J3|uniprotkb:Q9H4J4|uniprotkb:Q9UKL1|uniprotkb:Q9UM48|uniprotkb:Q9UM49|uniprotkb:Q9UM50|uniprotkb:Q5TGE3|uniprotkb:E1P629|uniprotkb:Q5TGE0|ensembl:ENSP00000360739	psi-mi:crel1_human(display_long)|uniprotkb:CRELD1(gene name)|psi-mi:CRELD1(display_short)|uniprotkb:CIRRIN(gene name synonym)|uniprotkb:Cysteine-rich with EGF-like domain protein 1(gene name synonym)|uniprotkb:UNQ188/PRO214(orf name)	psi-mi:ub2v1_human(display_long)|uniprotkb:CROC-1(gene name synonym)|uniprotkb:TRAF6-regulated IKK activator 1 beta Uev1A(gene name synonym)|uniprotkb:P/OKcl.19(orf name)|uniprotkb:UBE2V1(gene name)|psi-mi:UBE2V1(display_short)|uniprotkb:CROC1(gene name synonym)|uniprotkb:UBE2V(gene name synonym)|uniprotkb:UEV1(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9972513|imex:IM-22822-114	author-confidence:Z-score = 6.25	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001026887.1|refseq:NP_001070883.1|refseq:NP_056328.2|refseq:XP_016862664.1|ensembl:ENSG00000163703(gene)|ensembl:ENST00000383811(transcript)|ensembl:ENST00000452070(transcript)|ensembl:ENST00000682783(transcript)|ensembl:ENST00000684493(transcript)|go:"GO:0003197"(endocardial cushion development)|go:"GO:0003279"(cardiac septum development)|go:"GO:0003756"(protein disulfide isomerase activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0016021"(integral component of membrane)|go:"GO:0062023"(collagen-containing extracellular matrix)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR002049(EGF-like, laminin)|interpro:IPR006212(Furin-like repeat)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR018097|interpro:IPR021852|mint:Q96HD1	refseq:NP_001027459.1|refseq:NP_068823.2|refseq:NP_071887.1|refseq:NP_954595.1|refseq:NP_954673.1|refseq:NP_001244322.1|refseq:NP_001244323.1|refseq:NP_001244325.1|ensembl:ENSG00000244687(gene)|ensembl:ENST00000371674(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006282"(regulation of DNA repair)|go:"GO:0006301"(postreplication repair)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0030154"(cell differentiation)|go:"GO:0031371"(ubiquitin conjugating enzyme complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035370"(UBC13-UEV1A complex)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070534"(protein K63-linked ubiquitination)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|rcsb pdb:2A4D|rcsb pdb:2C2V|rcsb pdb:2HLW|rcsb pdb:6D6I|reactome:R-HSA-168638|reactome:R-HSA-168927|reactome:R-HSA-202424|reactome:R-HSA-2871837|reactome:R-HSA-445989|reactome:R-HSA-450302|reactome:R-HSA-450321|reactome:R-HSA-5607764|reactome:R-HSA-9020702|reactome:R-HSA-937039|reactome:R-HSA-937041|reactome:R-HSA-9646399|reactome:R-HSA-975110|reactome:R-HSA-975144|reactome:R-HSA-983168|dip:DIP-41911N	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S3|resulting-ptm:Q96HD1 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:YCHTMCBYRLSWAJ4W+2lmt/EjUlQ9606	rogid:x95N7Dj2KIqu5gySX59xLmfthUg9606	intact-crc:46A4EFA12D39CE2B|rigid:C+Hrxtw9LjsEt15/weNAOQ1SZMk	false	-	his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q96HD1	uniprotkb:P22314	intact:EBI-713009|uniprotkb:Q6I9X5|uniprotkb:Q8NFT4|uniprotkb:Q9Y409|uniprotkb:A8MX90|uniprotkb:B2RAA9|ensembl:ENSP00000373322|ensembl:ENSP00000393643|ensembl:ENSP00000507127|ensembl:ENSP00000508358	intact:EBI-709688|uniprotkb:Q96E13|uniprotkb:Q5JRR8|ensembl:ENSP00000338413|ensembl:ENSP00000366568	psi-mi:crel1_human(display_long)|uniprotkb:CRELD1(gene name)|psi-mi:CRELD1(display_short)|uniprotkb:CIRRIN(gene name synonym)|uniprotkb:Cysteine-rich with EGF-like domain protein 1(gene name synonym)|uniprotkb:UNQ188/PRO214(orf name)	psi-mi:uba1_human(display_long)|uniprotkb:Ubiquitin-activating enzyme E1(gene name synonym)|uniprotkb:Protein A1S9(gene name synonym)|uniprotkb:UBA1(gene name)|psi-mi:UBA1(display_short)|uniprotkb:A1S9T(gene name synonym)|uniprotkb:UBE1(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9972513|imex:IM-22822-114	author-confidence:Z-score = 6.25	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001026887.1|refseq:NP_001070883.1|refseq:NP_056328.2|refseq:XP_016862664.1|ensembl:ENSG00000163703(gene)|ensembl:ENST00000383811(transcript)|ensembl:ENST00000452070(transcript)|ensembl:ENST00000682783(transcript)|ensembl:ENST00000684493(transcript)|go:"GO:0003197"(endocardial cushion development)|go:"GO:0003279"(cardiac septum development)|go:"GO:0003756"(protein disulfide isomerase activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0016021"(integral component of membrane)|go:"GO:0062023"(collagen-containing extracellular matrix)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR002049(EGF-like, laminin)|interpro:IPR006212(Furin-like repeat)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR018097|interpro:IPR021852|mint:Q96HD1	refseq:NP_003325.2|refseq:NP_695012.1|refseq:XP_016885269.1|refseq:XP_016885270.1|dip:DIP-33686N|ensembl:ENSG00000130985(gene)|ensembl:ENST00000335972(transcript)|ensembl:ENST00000377351(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0004839"(ubiquitin activating enzyme activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0032446"(protein modification by small protein conjugation)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000011(Ubiquitin-activating enzyme, E1)|interpro:IPR000594(UBA/THIF-type NAD/FAD binding fold)|interpro:IPR018074|interpro:IPR018075|interpro:IPR018965|interpro:IPR019572|interpro:IPR032418|interpro:IPR032420|interpro:IPR033127|interpro:IPR035985|interpro:IPR038252|interpro:IPR042063|interpro:IPR042302|interpro:IPR042449|mint:P22314|rcsb pdb:4P22|rcsb pdb:6DC6|reactome:R-HSA-8866652|reactome:R-HSA-983168	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S3|resulting-ptm:Q96HD1 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:YCHTMCBYRLSWAJ4W+2lmt/EjUlQ9606	rogid:q+vEeA0XLST0Zz173bmEt0dNbDE9606	intact-crc:46A4EFA12D39CE2B|rigid:C+Hrxtw9LjsEt15/weNAOQ1SZMk	false	-	his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q96HD1	uniprotkb:P61088	intact:EBI-713009|uniprotkb:Q6I9X5|uniprotkb:Q8NFT4|uniprotkb:Q9Y409|uniprotkb:A8MX90|uniprotkb:B2RAA9|ensembl:ENSP00000373322|ensembl:ENSP00000393643|ensembl:ENSP00000507127|ensembl:ENSP00000508358	intact:EBI-1052908|uniprotkb:Q16781|uniprotkb:Q53Y81|ensembl:ENSP00000316176	psi-mi:crel1_human(display_long)|uniprotkb:CRELD1(gene name)|psi-mi:CRELD1(display_short)|uniprotkb:CIRRIN(gene name synonym)|uniprotkb:Cysteine-rich with EGF-like domain protein 1(gene name synonym)|uniprotkb:UNQ188/PRO214(orf name)	psi-mi:ube2n_human(display_long)|uniprotkb:Ubiquitin-protein ligase N(gene name synonym)|uniprotkb:Ubiquitin carrier protein N(gene name synonym)|uniprotkb:Ubc13(gene name synonym)|uniprotkb:Bendless-like ubiquitin-conjugating enzyme(gene name synonym)|uniprotkb:UBE2N(gene name)|psi-mi:UBE2N(display_short)|uniprotkb:BLU(gene name synonym)|uniprotkb:UbcH13(gene name synonym)|uniprotkb:E2 ubiquitin-conjugating enzyme N(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9972513|imex:IM-22822-114	author-confidence:Z-score = 6.25	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001026887.1|refseq:NP_001070883.1|refseq:NP_056328.2|refseq:XP_016862664.1|ensembl:ENSG00000163703(gene)|ensembl:ENST00000383811(transcript)|ensembl:ENST00000452070(transcript)|ensembl:ENST00000682783(transcript)|ensembl:ENST00000684493(transcript)|go:"GO:0003197"(endocardial cushion development)|go:"GO:0003279"(cardiac septum development)|go:"GO:0003756"(protein disulfide isomerase activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0016021"(integral component of membrane)|go:"GO:0062023"(collagen-containing extracellular matrix)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR002049(EGF-like, laminin)|interpro:IPR006212(Furin-like repeat)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR018097|interpro:IPR021852|mint:Q96HD1	refseq:NP_003339.1|dip:DIP-29829N|ensembl:ENSG00000177889(gene)|ensembl:ENST00000318066(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000729"(DNA double-strand break processing)|go:"GO:0001650"(fibrillar center)|go:"GO:0003723"(RNA binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006282"(regulation of DNA repair)|go:"GO:0006301"(postreplication repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016574"(histone ubiquitination)|go:"GO:0031058"(positive regulation of histone modification)|go:"GO:0031372"(UBC13-MMS2 complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033182"(regulation of histone ubiquitination)|go:"GO:0035370"(UBC13-UEV1A complex)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0061631"(ubiquitin conjugating enzyme activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070534"(protein K63-linked ubiquitination)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|interpro:IPR023313|rcsb pdb:1J7D|rcsb pdb:2C2V|rcsb pdb:3HCT|rcsb pdb:3HCU|rcsb pdb:3VON|rcsb pdb:3W31|rcsb pdb:4DHI|rcsb pdb:4DHJ|rcsb pdb:4DHZ|rcsb pdb:4IP3|rcsb pdb:4NR3|rcsb pdb:4NRG|rcsb pdb:4NRI|rcsb pdb:4ONL|rcsb pdb:4ONM|rcsb pdb:4ONN|rcsb pdb:4ORH|rcsb pdb:4TKP|rcsb pdb:4WHV|rcsb pdb:5AIT|rcsb pdb:5AIU|rcsb pdb:5EYA|rcsb pdb:5H7S|rcsb pdb:5VNZ|rcsb pdb:5VO0|rcsb pdb:5YWR|rcsb pdb:6D6I|rcsb pdb:6JKY|rcsb pdb:6KFP|rcsb pdb:6KG6|rcsb pdb:6KL4|rcsb pdb:6LP2|rcsb pdb:6P5B|rcsb pdb:6S53|reactome:R-HSA-168927|reactome:R-HSA-202424|reactome:R-HSA-2871837|reactome:R-HSA-445989|reactome:R-HSA-450302|reactome:R-HSA-450321|reactome:R-HSA-5607764|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-5696395|reactome:R-HSA-69473|reactome:R-HSA-8866654|reactome:R-HSA-9020702|reactome:R-HSA-937039|reactome:R-HSA-937041|reactome:R-HSA-9646399|reactome:R-HSA-975110|reactome:R-HSA-975144|reactome:R-HSA-983168|rcsb pdb:6ULH|rcsb pdb:6UMP|rcsb pdb:6UMS|rcsb pdb:7BBD|rcsb pdb:7BBF|rcsb pdb:7BXG|reactome:R-HSA-1169408|reactome:R-HSA-168638	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S3|resulting-ptm:Q96HD1 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:YCHTMCBYRLSWAJ4W+2lmt/EjUlQ9606	rogid:dqdszHlq5FLPHC6UWX6uvkC6Yz89606	intact-crc:46A4EFA12D39CE2B|rigid:C+Hrxtw9LjsEt15/weNAOQ1SZMk	false	-	his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q96GG9	uniprotkb:Q62925	intact:EBI-740086|uniprotkb:B2RB37|uniprotkb:Q7L3G9|uniprotkb:Q8TEX7|uniprotkb:Q9H6M1|uniprotkb:Q9HCT3|ensembl:ENSP00000292782	intact:EBI-636664	psi-mi:dcnl1_human(display_long)|uniprotkb:DCUN1D1(gene name)|psi-mi:DCUN1D1(display_short)|uniprotkb:DCUN1L1(gene name synonym)|uniprotkb:RP42(gene name synonym)|uniprotkb:SCCRO(gene name synonym)|uniprotkb:Defective in cullin neddylation protein 1-like protein 1(gene name synonym)|uniprotkb:DCUN1 domain-containing protein 1(gene name synonym)|uniprotkb:Squamous cell carcinoma-related oncogene(gene name synonym)|uniprotkb:DCN1(gene name synonym)	psi-mi:m3k1_rat(display_long)|uniprotkb:MAPK/ERK kinase kinase 1(gene name synonym)|uniprotkb:Map3k1(gene name)|psi-mi:Map3k1(display_short)|uniprotkb:Mekk(gene name synonym)|uniprotkb:Mekk1(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9972488|imex:IM-22822-113	author-confidence:Z-score = 9.65	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_065691.2|ensembl:ENSG00000043093(gene)|ensembl:ENST00000292782(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0031396"(regulation of protein ubiquitination)|go:"GO:0032182"(ubiquitin-like protein binding)|go:"GO:0045116"(protein neddylation)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0097602"(cullin family protein binding)|go:"GO:2000434"(regulation of protein neddylation)|go:"GO:2000436"(positive regulation of protein neddylation)|interpro:IPR005176(Protein of unknown function DUF298)|interpro:IPR009060(UBA-like)|interpro:IPR014764(Defective in cullin neddylation)|interpro:IPR042460|rcsb pdb:3TDU|rcsb pdb:3TDZ|rcsb pdb:4P5O|rcsb pdb:5UFI|rcsb pdb:5V83|rcsb pdb:5V86|go:"GO:0031624"(ubiquitin conjugating enzyme binding)|rcsb pdb:6B5Q|rcsb pdb:6BG3|rcsb pdb:6BG5|rcsb pdb:6P5V|rcsb pdb:6P5W|rcsb pdb:6XOL|rcsb pdb:6XOM|rcsb pdb:6XON|rcsb pdb:6XOO|rcsb pdb:6XOP|rcsb pdb:6XOQ|reactome:R-HSA-8951664|rcsb pdb:5V88|refseq:NP_001295030.1|dip:DIP-42121N	rgd:620966|refseq:NP_446339.1|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR007527(Zinc finger, SWIM-type)|go:"GO:0000165"(MAPK cascade)|interpro:IPR016024(Armadillo-type fold)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0002011"(morphogenesis of an epithelial sheet)|go:"GO:0003382"(epithelial cell morphogenesis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004706"(JUN kinase kinase kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007254"(JNK cascade)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008432"(JUN kinase binding)|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0016020"(membrane)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0031434"(mitogen-activated protein kinase kinase binding)|go:"GO:0031941"(filamentous actin)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0042060"(wound healing)|go:"GO:0043010"(camera-type eye development)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046625"(sphingolipid binding)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050434"(positive regulation of viral transcription)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0061029"(eyelid development in camera-type eye)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|reactome:R-RNO-166058|reactome:R-RNO-2871796|reactome:R-RNO-975138|reactome:R-RNO-975871|interpro:IPR011989(Armadillo-like helical)|mint:Q62925	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S3|resulting-ptm:Q96GG9 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:TiHJulV7MphxjMdNbVvrlQKkAPo9606	rogid:EwhjYjowkZIAt4UyPcZBUtf9uak10116	intact-crc:216FD8C0B896B548|rigid:D0FSDiv5Z+1QMEmNWSnQ9CcFpFg	false	-	sufficient binding region:433-481(IPR013083)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q96GG9	uniprotkb:Q13404	intact:EBI-740086|uniprotkb:B2RB37|uniprotkb:Q7L3G9|uniprotkb:Q8TEX7|uniprotkb:Q9H6M1|uniprotkb:Q9HCT3|ensembl:ENSP00000292782	intact:EBI-1050671|uniprotkb:Q13403|uniprotkb:Q13532|uniprotkb:Q96H34|uniprotkb:Q9GZT0|uniprotkb:Q9GZW1|uniprotkb:Q9H4J3|uniprotkb:Q9H4J4|uniprotkb:Q9UKL1|uniprotkb:Q9UM48|uniprotkb:Q9UM49|uniprotkb:Q9UM50|uniprotkb:Q5TGE3|uniprotkb:E1P629|uniprotkb:Q5TGE0|ensembl:ENSP00000360739	psi-mi:dcnl1_human(display_long)|uniprotkb:DCUN1D1(gene name)|psi-mi:DCUN1D1(display_short)|uniprotkb:DCUN1L1(gene name synonym)|uniprotkb:RP42(gene name synonym)|uniprotkb:SCCRO(gene name synonym)|uniprotkb:Defective in cullin neddylation protein 1-like protein 1(gene name synonym)|uniprotkb:DCUN1 domain-containing protein 1(gene name synonym)|uniprotkb:Squamous cell carcinoma-related oncogene(gene name synonym)|uniprotkb:DCN1(gene name synonym)	psi-mi:ub2v1_human(display_long)|uniprotkb:CROC-1(gene name synonym)|uniprotkb:TRAF6-regulated IKK activator 1 beta Uev1A(gene name synonym)|uniprotkb:P/OKcl.19(orf name)|uniprotkb:UBE2V1(gene name)|psi-mi:UBE2V1(display_short)|uniprotkb:CROC1(gene name synonym)|uniprotkb:UBE2V(gene name synonym)|uniprotkb:UEV1(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9972488|imex:IM-22822-113	author-confidence:Z-score = 9.65	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_065691.2|ensembl:ENSG00000043093(gene)|ensembl:ENST00000292782(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0031396"(regulation of protein ubiquitination)|go:"GO:0032182"(ubiquitin-like protein binding)|go:"GO:0045116"(protein neddylation)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0097602"(cullin family protein binding)|go:"GO:2000434"(regulation of protein neddylation)|go:"GO:2000436"(positive regulation of protein neddylation)|interpro:IPR005176(Protein of unknown function DUF298)|interpro:IPR009060(UBA-like)|interpro:IPR014764(Defective in cullin neddylation)|interpro:IPR042460|rcsb pdb:3TDU|rcsb pdb:3TDZ|rcsb pdb:4P5O|rcsb pdb:5UFI|rcsb pdb:5V83|rcsb pdb:5V86|go:"GO:0031624"(ubiquitin conjugating enzyme binding)|rcsb pdb:6B5Q|rcsb pdb:6BG3|rcsb pdb:6BG5|rcsb pdb:6P5V|rcsb pdb:6P5W|rcsb pdb:6XOL|rcsb pdb:6XOM|rcsb pdb:6XON|rcsb pdb:6XOO|rcsb pdb:6XOP|rcsb pdb:6XOQ|reactome:R-HSA-8951664|rcsb pdb:5V88|refseq:NP_001295030.1|dip:DIP-42121N	refseq:NP_001027459.1|refseq:NP_068823.2|refseq:NP_071887.1|refseq:NP_954595.1|refseq:NP_954673.1|refseq:NP_001244322.1|refseq:NP_001244323.1|refseq:NP_001244325.1|ensembl:ENSG00000244687(gene)|ensembl:ENST00000371674(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006282"(regulation of DNA repair)|go:"GO:0006301"(postreplication repair)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0030154"(cell differentiation)|go:"GO:0031371"(ubiquitin conjugating enzyme complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035370"(UBC13-UEV1A complex)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070534"(protein K63-linked ubiquitination)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|rcsb pdb:2A4D|rcsb pdb:2C2V|rcsb pdb:2HLW|rcsb pdb:6D6I|reactome:R-HSA-168638|reactome:R-HSA-168927|reactome:R-HSA-202424|reactome:R-HSA-2871837|reactome:R-HSA-445989|reactome:R-HSA-450302|reactome:R-HSA-450321|reactome:R-HSA-5607764|reactome:R-HSA-9020702|reactome:R-HSA-937039|reactome:R-HSA-937041|reactome:R-HSA-9646399|reactome:R-HSA-975110|reactome:R-HSA-975144|reactome:R-HSA-983168|dip:DIP-41911N	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S3|resulting-ptm:Q96GG9 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:TiHJulV7MphxjMdNbVvrlQKkAPo9606	rogid:x95N7Dj2KIqu5gySX59xLmfthUg9606	intact-crc:216FD8C0B896B548|rigid:D0FSDiv5Z+1QMEmNWSnQ9CcFpFg	false	-	his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q96GG9	uniprotkb:P22314	intact:EBI-740086|uniprotkb:B2RB37|uniprotkb:Q7L3G9|uniprotkb:Q8TEX7|uniprotkb:Q9H6M1|uniprotkb:Q9HCT3|ensembl:ENSP00000292782	intact:EBI-709688|uniprotkb:Q96E13|uniprotkb:Q5JRR8|ensembl:ENSP00000338413|ensembl:ENSP00000366568	psi-mi:dcnl1_human(display_long)|uniprotkb:DCUN1D1(gene name)|psi-mi:DCUN1D1(display_short)|uniprotkb:DCUN1L1(gene name synonym)|uniprotkb:RP42(gene name synonym)|uniprotkb:SCCRO(gene name synonym)|uniprotkb:Defective in cullin neddylation protein 1-like protein 1(gene name synonym)|uniprotkb:DCUN1 domain-containing protein 1(gene name synonym)|uniprotkb:Squamous cell carcinoma-related oncogene(gene name synonym)|uniprotkb:DCN1(gene name synonym)	psi-mi:uba1_human(display_long)|uniprotkb:Ubiquitin-activating enzyme E1(gene name synonym)|uniprotkb:Protein A1S9(gene name synonym)|uniprotkb:UBA1(gene name)|psi-mi:UBA1(display_short)|uniprotkb:A1S9T(gene name synonym)|uniprotkb:UBE1(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9972488|imex:IM-22822-113	author-confidence:Z-score = 9.65	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_065691.2|ensembl:ENSG00000043093(gene)|ensembl:ENST00000292782(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0031396"(regulation of protein ubiquitination)|go:"GO:0032182"(ubiquitin-like protein binding)|go:"GO:0045116"(protein neddylation)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0097602"(cullin family protein binding)|go:"GO:2000434"(regulation of protein neddylation)|go:"GO:2000436"(positive regulation of protein neddylation)|interpro:IPR005176(Protein of unknown function DUF298)|interpro:IPR009060(UBA-like)|interpro:IPR014764(Defective in cullin neddylation)|interpro:IPR042460|rcsb pdb:3TDU|rcsb pdb:3TDZ|rcsb pdb:4P5O|rcsb pdb:5UFI|rcsb pdb:5V83|rcsb pdb:5V86|go:"GO:0031624"(ubiquitin conjugating enzyme binding)|rcsb pdb:6B5Q|rcsb pdb:6BG3|rcsb pdb:6BG5|rcsb pdb:6P5V|rcsb pdb:6P5W|rcsb pdb:6XOL|rcsb pdb:6XOM|rcsb pdb:6XON|rcsb pdb:6XOO|rcsb pdb:6XOP|rcsb pdb:6XOQ|reactome:R-HSA-8951664|rcsb pdb:5V88|refseq:NP_001295030.1|dip:DIP-42121N	refseq:NP_003325.2|refseq:NP_695012.1|refseq:XP_016885269.1|refseq:XP_016885270.1|dip:DIP-33686N|ensembl:ENSG00000130985(gene)|ensembl:ENST00000335972(transcript)|ensembl:ENST00000377351(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0004839"(ubiquitin activating enzyme activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0032446"(protein modification by small protein conjugation)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000011(Ubiquitin-activating enzyme, E1)|interpro:IPR000594(UBA/THIF-type NAD/FAD binding fold)|interpro:IPR018074|interpro:IPR018075|interpro:IPR018965|interpro:IPR019572|interpro:IPR032418|interpro:IPR032420|interpro:IPR033127|interpro:IPR035985|interpro:IPR038252|interpro:IPR042063|interpro:IPR042302|interpro:IPR042449|mint:P22314|rcsb pdb:4P22|rcsb pdb:6DC6|reactome:R-HSA-8866652|reactome:R-HSA-983168	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S3|resulting-ptm:Q96GG9 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:TiHJulV7MphxjMdNbVvrlQKkAPo9606	rogid:q+vEeA0XLST0Zz173bmEt0dNbDE9606	intact-crc:216FD8C0B896B548|rigid:D0FSDiv5Z+1QMEmNWSnQ9CcFpFg	false	-	his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q96GG9	uniprotkb:P61088	intact:EBI-740086|uniprotkb:B2RB37|uniprotkb:Q7L3G9|uniprotkb:Q8TEX7|uniprotkb:Q9H6M1|uniprotkb:Q9HCT3|ensembl:ENSP00000292782	intact:EBI-1052908|uniprotkb:Q16781|uniprotkb:Q53Y81|ensembl:ENSP00000316176	psi-mi:dcnl1_human(display_long)|uniprotkb:DCUN1D1(gene name)|psi-mi:DCUN1D1(display_short)|uniprotkb:DCUN1L1(gene name synonym)|uniprotkb:RP42(gene name synonym)|uniprotkb:SCCRO(gene name synonym)|uniprotkb:Defective in cullin neddylation protein 1-like protein 1(gene name synonym)|uniprotkb:DCUN1 domain-containing protein 1(gene name synonym)|uniprotkb:Squamous cell carcinoma-related oncogene(gene name synonym)|uniprotkb:DCN1(gene name synonym)	psi-mi:ube2n_human(display_long)|uniprotkb:Ubiquitin-protein ligase N(gene name synonym)|uniprotkb:Ubiquitin carrier protein N(gene name synonym)|uniprotkb:Ubc13(gene name synonym)|uniprotkb:Bendless-like ubiquitin-conjugating enzyme(gene name synonym)|uniprotkb:UBE2N(gene name)|psi-mi:UBE2N(display_short)|uniprotkb:BLU(gene name synonym)|uniprotkb:UbcH13(gene name synonym)|uniprotkb:E2 ubiquitin-conjugating enzyme N(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9972488|imex:IM-22822-113	author-confidence:Z-score = 9.65	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_065691.2|ensembl:ENSG00000043093(gene)|ensembl:ENST00000292782(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0031396"(regulation of protein ubiquitination)|go:"GO:0032182"(ubiquitin-like protein binding)|go:"GO:0045116"(protein neddylation)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0097602"(cullin family protein binding)|go:"GO:2000434"(regulation of protein neddylation)|go:"GO:2000436"(positive regulation of protein neddylation)|interpro:IPR005176(Protein of unknown function DUF298)|interpro:IPR009060(UBA-like)|interpro:IPR014764(Defective in cullin neddylation)|interpro:IPR042460|rcsb pdb:3TDU|rcsb pdb:3TDZ|rcsb pdb:4P5O|rcsb pdb:5UFI|rcsb pdb:5V83|rcsb pdb:5V86|go:"GO:0031624"(ubiquitin conjugating enzyme binding)|rcsb pdb:6B5Q|rcsb pdb:6BG3|rcsb pdb:6BG5|rcsb pdb:6P5V|rcsb pdb:6P5W|rcsb pdb:6XOL|rcsb pdb:6XOM|rcsb pdb:6XON|rcsb pdb:6XOO|rcsb pdb:6XOP|rcsb pdb:6XOQ|reactome:R-HSA-8951664|rcsb pdb:5V88|refseq:NP_001295030.1|dip:DIP-42121N	refseq:NP_003339.1|dip:DIP-29829N|ensembl:ENSG00000177889(gene)|ensembl:ENST00000318066(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000729"(DNA double-strand break processing)|go:"GO:0001650"(fibrillar center)|go:"GO:0003723"(RNA binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006282"(regulation of DNA repair)|go:"GO:0006301"(postreplication repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016574"(histone ubiquitination)|go:"GO:0031058"(positive regulation of histone modification)|go:"GO:0031372"(UBC13-MMS2 complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033182"(regulation of histone ubiquitination)|go:"GO:0035370"(UBC13-UEV1A complex)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0061631"(ubiquitin conjugating enzyme activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070534"(protein K63-linked ubiquitination)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|interpro:IPR023313|rcsb pdb:1J7D|rcsb pdb:2C2V|rcsb pdb:3HCT|rcsb pdb:3HCU|rcsb pdb:3VON|rcsb pdb:3W31|rcsb pdb:4DHI|rcsb pdb:4DHJ|rcsb pdb:4DHZ|rcsb pdb:4IP3|rcsb pdb:4NR3|rcsb pdb:4NRG|rcsb pdb:4NRI|rcsb pdb:4ONL|rcsb pdb:4ONM|rcsb pdb:4ONN|rcsb pdb:4ORH|rcsb pdb:4TKP|rcsb pdb:4WHV|rcsb pdb:5AIT|rcsb pdb:5AIU|rcsb pdb:5EYA|rcsb pdb:5H7S|rcsb pdb:5VNZ|rcsb pdb:5VO0|rcsb pdb:5YWR|rcsb pdb:6D6I|rcsb pdb:6JKY|rcsb pdb:6KFP|rcsb pdb:6KG6|rcsb pdb:6KL4|rcsb pdb:6LP2|rcsb pdb:6P5B|rcsb pdb:6S53|reactome:R-HSA-168927|reactome:R-HSA-202424|reactome:R-HSA-2871837|reactome:R-HSA-445989|reactome:R-HSA-450302|reactome:R-HSA-450321|reactome:R-HSA-5607764|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-5696395|reactome:R-HSA-69473|reactome:R-HSA-8866654|reactome:R-HSA-9020702|reactome:R-HSA-937039|reactome:R-HSA-937041|reactome:R-HSA-9646399|reactome:R-HSA-975110|reactome:R-HSA-975144|reactome:R-HSA-983168|rcsb pdb:6ULH|rcsb pdb:6UMP|rcsb pdb:6UMS|rcsb pdb:7BBD|rcsb pdb:7BBF|rcsb pdb:7BXG|reactome:R-HSA-1169408|reactome:R-HSA-168638	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S3|resulting-ptm:Q96GG9 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:TiHJulV7MphxjMdNbVvrlQKkAPo9606	rogid:dqdszHlq5FLPHC6UWX6uvkC6Yz89606	intact-crc:216FD8C0B896B548|rigid:D0FSDiv5Z+1QMEmNWSnQ9CcFpFg	false	-	his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q62925	uniprotkb:Q9BV68	intact:EBI-636664	intact:EBI-357322|ensembl:ENSP00000292363|uniprotkb:Q9NWX1|intact:EBI-11064977	psi-mi:m3k1_rat(display_long)|uniprotkb:MAPK/ERK kinase kinase 1(gene name synonym)|uniprotkb:Map3k1(gene name)|psi-mi:Map3k1(display_short)|uniprotkb:Mekk(gene name synonym)|uniprotkb:Mekk1(gene name synonym)	psi-mi:rn126_human(display_long)|uniprotkb:RNF126(gene name)|psi-mi:RNF126(display_short)|uniprotkb:RING finger protein 126(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9972563|imex:IM-22822-116	author-confidence:Z-score = 3.90	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:620966|refseq:NP_446339.1|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR007527(Zinc finger, SWIM-type)|go:"GO:0000165"(MAPK cascade)|interpro:IPR016024(Armadillo-type fold)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0002011"(morphogenesis of an epithelial sheet)|go:"GO:0003382"(epithelial cell morphogenesis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004706"(JUN kinase kinase kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007254"(JNK cascade)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008432"(JUN kinase binding)|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0016020"(membrane)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0031434"(mitogen-activated protein kinase kinase binding)|go:"GO:0031941"(filamentous actin)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0042060"(wound healing)|go:"GO:0043010"(camera-type eye development)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046625"(sphingolipid binding)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050434"(positive regulation of viral transcription)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0061029"(eyelid development in camera-type eye)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|reactome:R-RNO-166058|reactome:R-RNO-2871796|reactome:R-RNO-975138|reactome:R-RNO-975871|interpro:IPR011989(Armadillo-like helical)|mint:Q62925	ensembl:ENSG00000070423(gene)|ensembl:ENST00000292363(transcript)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006513"(protein monoubiquitination)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042147"(retrograde transport, endosome to Golgi)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043162"(ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway)|go:"GO:0046872"(metal ion binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0070936"(protein K48-linked ubiquitination)|go:"GO:0071629"(cytoplasm protein quality control by the ubiquitin-proteasome system)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR039525|interpro:IPR039571|interpro:IPR039572|rcsb pdb:2N9O|rcsb pdb:2N9P|reactome:R-HSA-983168|go:"GO:0042059"(negative regulation of epidermal growth factor receptor signaling pathway)|refseq:NP_919442.1	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S3|resulting-ptm:Q9BV68 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2019/01/23	rogid:EwhjYjowkZIAt4UyPcZBUtf9uak10116	rogid:4Z4AJGHJgoIUp9zhtfWcFBF1Fxw9606	intact-crc:BC9BA5279D0AE258|rigid:v5drdyIX5b+uCboVmEQtmqzW02E	false	sufficient binding region:433-481(IPR013083)	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q62925	uniprotkb:Q13404	intact:EBI-636664	intact:EBI-1050671|uniprotkb:Q13403|uniprotkb:Q13532|uniprotkb:Q96H34|uniprotkb:Q9GZT0|uniprotkb:Q9GZW1|uniprotkb:Q9H4J3|uniprotkb:Q9H4J4|uniprotkb:Q9UKL1|uniprotkb:Q9UM48|uniprotkb:Q9UM49|uniprotkb:Q9UM50|uniprotkb:Q5TGE3|uniprotkb:E1P629|uniprotkb:Q5TGE0|ensembl:ENSP00000360739	psi-mi:m3k1_rat(display_long)|uniprotkb:MAPK/ERK kinase kinase 1(gene name synonym)|uniprotkb:Map3k1(gene name)|psi-mi:Map3k1(display_short)|uniprotkb:Mekk(gene name synonym)|uniprotkb:Mekk1(gene name synonym)	psi-mi:ub2v1_human(display_long)|uniprotkb:CROC-1(gene name synonym)|uniprotkb:TRAF6-regulated IKK activator 1 beta Uev1A(gene name synonym)|uniprotkb:P/OKcl.19(orf name)|uniprotkb:UBE2V1(gene name)|psi-mi:UBE2V1(display_short)|uniprotkb:CROC1(gene name synonym)|uniprotkb:UBE2V(gene name synonym)|uniprotkb:UEV1(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9972563|imex:IM-22822-116	author-confidence:Z-score = 3.90	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:620966|refseq:NP_446339.1|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR007527(Zinc finger, SWIM-type)|go:"GO:0000165"(MAPK cascade)|interpro:IPR016024(Armadillo-type fold)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0002011"(morphogenesis of an epithelial sheet)|go:"GO:0003382"(epithelial cell morphogenesis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004706"(JUN kinase kinase kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007254"(JNK cascade)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008432"(JUN kinase binding)|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0016020"(membrane)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0031434"(mitogen-activated protein kinase kinase binding)|go:"GO:0031941"(filamentous actin)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0042060"(wound healing)|go:"GO:0043010"(camera-type eye development)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046625"(sphingolipid binding)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050434"(positive regulation of viral transcription)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0061029"(eyelid development in camera-type eye)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|reactome:R-RNO-166058|reactome:R-RNO-2871796|reactome:R-RNO-975138|reactome:R-RNO-975871|interpro:IPR011989(Armadillo-like helical)|mint:Q62925	refseq:NP_001027459.1|refseq:NP_068823.2|refseq:NP_071887.1|refseq:NP_954595.1|refseq:NP_954673.1|refseq:NP_001244322.1|refseq:NP_001244323.1|refseq:NP_001244325.1|ensembl:ENSG00000244687(gene)|ensembl:ENST00000371674(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006282"(regulation of DNA repair)|go:"GO:0006301"(postreplication repair)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0030154"(cell differentiation)|go:"GO:0031371"(ubiquitin conjugating enzyme complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035370"(UBC13-UEV1A complex)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070534"(protein K63-linked ubiquitination)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|rcsb pdb:2A4D|rcsb pdb:2C2V|rcsb pdb:2HLW|rcsb pdb:6D6I|reactome:R-HSA-168638|reactome:R-HSA-168927|reactome:R-HSA-202424|reactome:R-HSA-2871837|reactome:R-HSA-445989|reactome:R-HSA-450302|reactome:R-HSA-450321|reactome:R-HSA-5607764|reactome:R-HSA-9020702|reactome:R-HSA-937039|reactome:R-HSA-937041|reactome:R-HSA-9646399|reactome:R-HSA-975110|reactome:R-HSA-975144|reactome:R-HSA-983168|dip:DIP-41911N	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S3|resulting-ptm:Q9BV68 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2019/01/23	rogid:EwhjYjowkZIAt4UyPcZBUtf9uak10116	rogid:x95N7Dj2KIqu5gySX59xLmfthUg9606	intact-crc:BC9BA5279D0AE258|rigid:v5drdyIX5b+uCboVmEQtmqzW02E	false	sufficient binding region:433-481(IPR013083)	his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q62925	uniprotkb:P22314	intact:EBI-636664	intact:EBI-709688|uniprotkb:Q96E13|uniprotkb:Q5JRR8|ensembl:ENSP00000338413|ensembl:ENSP00000366568	psi-mi:m3k1_rat(display_long)|uniprotkb:MAPK/ERK kinase kinase 1(gene name synonym)|uniprotkb:Map3k1(gene name)|psi-mi:Map3k1(display_short)|uniprotkb:Mekk(gene name synonym)|uniprotkb:Mekk1(gene name synonym)	psi-mi:uba1_human(display_long)|uniprotkb:Ubiquitin-activating enzyme E1(gene name synonym)|uniprotkb:Protein A1S9(gene name synonym)|uniprotkb:UBA1(gene name)|psi-mi:UBA1(display_short)|uniprotkb:A1S9T(gene name synonym)|uniprotkb:UBE1(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9972563|imex:IM-22822-116	author-confidence:Z-score = 3.90	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:620966|refseq:NP_446339.1|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR007527(Zinc finger, SWIM-type)|go:"GO:0000165"(MAPK cascade)|interpro:IPR016024(Armadillo-type fold)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0002011"(morphogenesis of an epithelial sheet)|go:"GO:0003382"(epithelial cell morphogenesis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004706"(JUN kinase kinase kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007254"(JNK cascade)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008432"(JUN kinase binding)|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0016020"(membrane)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0031434"(mitogen-activated protein kinase kinase binding)|go:"GO:0031941"(filamentous actin)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0042060"(wound healing)|go:"GO:0043010"(camera-type eye development)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046625"(sphingolipid binding)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050434"(positive regulation of viral transcription)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0061029"(eyelid development in camera-type eye)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|reactome:R-RNO-166058|reactome:R-RNO-2871796|reactome:R-RNO-975138|reactome:R-RNO-975871|interpro:IPR011989(Armadillo-like helical)|mint:Q62925	refseq:NP_003325.2|refseq:NP_695012.1|refseq:XP_016885269.1|refseq:XP_016885270.1|dip:DIP-33686N|ensembl:ENSG00000130985(gene)|ensembl:ENST00000335972(transcript)|ensembl:ENST00000377351(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0004839"(ubiquitin activating enzyme activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0032446"(protein modification by small protein conjugation)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000011(Ubiquitin-activating enzyme, E1)|interpro:IPR000594(UBA/THIF-type NAD/FAD binding fold)|interpro:IPR018074|interpro:IPR018075|interpro:IPR018965|interpro:IPR019572|interpro:IPR032418|interpro:IPR032420|interpro:IPR033127|interpro:IPR035985|interpro:IPR038252|interpro:IPR042063|interpro:IPR042302|interpro:IPR042449|mint:P22314|rcsb pdb:4P22|rcsb pdb:6DC6|reactome:R-HSA-8866652|reactome:R-HSA-983168	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S3|resulting-ptm:Q9BV68 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2019/01/23	rogid:EwhjYjowkZIAt4UyPcZBUtf9uak10116	rogid:q+vEeA0XLST0Zz173bmEt0dNbDE9606	intact-crc:BC9BA5279D0AE258|rigid:v5drdyIX5b+uCboVmEQtmqzW02E	false	sufficient binding region:433-481(IPR013083)	his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q62925	uniprotkb:P61088	intact:EBI-636664	intact:EBI-1052908|uniprotkb:Q16781|uniprotkb:Q53Y81|ensembl:ENSP00000316176	psi-mi:m3k1_rat(display_long)|uniprotkb:MAPK/ERK kinase kinase 1(gene name synonym)|uniprotkb:Map3k1(gene name)|psi-mi:Map3k1(display_short)|uniprotkb:Mekk(gene name synonym)|uniprotkb:Mekk1(gene name synonym)	psi-mi:ube2n_human(display_long)|uniprotkb:Ubiquitin-protein ligase N(gene name synonym)|uniprotkb:Ubiquitin carrier protein N(gene name synonym)|uniprotkb:Ubc13(gene name synonym)|uniprotkb:Bendless-like ubiquitin-conjugating enzyme(gene name synonym)|uniprotkb:UBE2N(gene name)|psi-mi:UBE2N(display_short)|uniprotkb:BLU(gene name synonym)|uniprotkb:UbcH13(gene name synonym)|uniprotkb:E2 ubiquitin-conjugating enzyme N(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9972563|imex:IM-22822-116	author-confidence:Z-score = 3.90	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:620966|refseq:NP_446339.1|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR007527(Zinc finger, SWIM-type)|go:"GO:0000165"(MAPK cascade)|interpro:IPR016024(Armadillo-type fold)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0002011"(morphogenesis of an epithelial sheet)|go:"GO:0003382"(epithelial cell morphogenesis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004706"(JUN kinase kinase kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007254"(JNK cascade)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008432"(JUN kinase binding)|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0016020"(membrane)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0031434"(mitogen-activated protein kinase kinase binding)|go:"GO:0031941"(filamentous actin)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0042060"(wound healing)|go:"GO:0043010"(camera-type eye development)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046625"(sphingolipid binding)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050434"(positive regulation of viral transcription)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0061029"(eyelid development in camera-type eye)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|reactome:R-RNO-166058|reactome:R-RNO-2871796|reactome:R-RNO-975138|reactome:R-RNO-975871|interpro:IPR011989(Armadillo-like helical)|mint:Q62925	refseq:NP_003339.1|dip:DIP-29829N|ensembl:ENSG00000177889(gene)|ensembl:ENST00000318066(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000729"(DNA double-strand break processing)|go:"GO:0001650"(fibrillar center)|go:"GO:0003723"(RNA binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006282"(regulation of DNA repair)|go:"GO:0006301"(postreplication repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016574"(histone ubiquitination)|go:"GO:0031058"(positive regulation of histone modification)|go:"GO:0031372"(UBC13-MMS2 complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033182"(regulation of histone ubiquitination)|go:"GO:0035370"(UBC13-UEV1A complex)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0061631"(ubiquitin conjugating enzyme activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070534"(protein K63-linked ubiquitination)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|interpro:IPR023313|rcsb pdb:1J7D|rcsb pdb:2C2V|rcsb pdb:3HCT|rcsb pdb:3HCU|rcsb pdb:3VON|rcsb pdb:3W31|rcsb pdb:4DHI|rcsb pdb:4DHJ|rcsb pdb:4DHZ|rcsb pdb:4IP3|rcsb pdb:4NR3|rcsb pdb:4NRG|rcsb pdb:4NRI|rcsb pdb:4ONL|rcsb pdb:4ONM|rcsb pdb:4ONN|rcsb pdb:4ORH|rcsb pdb:4TKP|rcsb pdb:4WHV|rcsb pdb:5AIT|rcsb pdb:5AIU|rcsb pdb:5EYA|rcsb pdb:5H7S|rcsb pdb:5VNZ|rcsb pdb:5VO0|rcsb pdb:5YWR|rcsb pdb:6D6I|rcsb pdb:6JKY|rcsb pdb:6KFP|rcsb pdb:6KG6|rcsb pdb:6KL4|rcsb pdb:6LP2|rcsb pdb:6P5B|rcsb pdb:6S53|reactome:R-HSA-168927|reactome:R-HSA-202424|reactome:R-HSA-2871837|reactome:R-HSA-445989|reactome:R-HSA-450302|reactome:R-HSA-450321|reactome:R-HSA-5607764|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-5696395|reactome:R-HSA-69473|reactome:R-HSA-8866654|reactome:R-HSA-9020702|reactome:R-HSA-937039|reactome:R-HSA-937041|reactome:R-HSA-9646399|reactome:R-HSA-975110|reactome:R-HSA-975144|reactome:R-HSA-983168|rcsb pdb:6ULH|rcsb pdb:6UMP|rcsb pdb:6UMS|rcsb pdb:7BBD|rcsb pdb:7BBF|rcsb pdb:7BXG|reactome:R-HSA-1169408|reactome:R-HSA-168638	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S3|resulting-ptm:Q9BV68 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2019/01/23	rogid:EwhjYjowkZIAt4UyPcZBUtf9uak10116	rogid:dqdszHlq5FLPHC6UWX6uvkC6Yz89606	intact-crc:BC9BA5279D0AE258|rigid:v5drdyIX5b+uCboVmEQtmqzW02E	false	sufficient binding region:433-481(IPR013083)	his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q62925	uniprotkb:Q13404	intact:EBI-636664	intact:EBI-1050671|uniprotkb:Q13403|uniprotkb:Q13532|uniprotkb:Q96H34|uniprotkb:Q9GZT0|uniprotkb:Q9GZW1|uniprotkb:Q9H4J3|uniprotkb:Q9H4J4|uniprotkb:Q9UKL1|uniprotkb:Q9UM48|uniprotkb:Q9UM49|uniprotkb:Q9UM50|uniprotkb:Q5TGE3|uniprotkb:E1P629|uniprotkb:Q5TGE0|ensembl:ENSP00000360739	psi-mi:m3k1_rat(display_long)|uniprotkb:MAPK/ERK kinase kinase 1(gene name synonym)|uniprotkb:Map3k1(gene name)|psi-mi:Map3k1(display_short)|uniprotkb:Mekk(gene name synonym)|uniprotkb:Mekk1(gene name synonym)	psi-mi:ub2v1_human(display_long)|uniprotkb:CROC-1(gene name synonym)|uniprotkb:TRAF6-regulated IKK activator 1 beta Uev1A(gene name synonym)|uniprotkb:P/OKcl.19(orf name)|uniprotkb:UBE2V1(gene name)|psi-mi:UBE2V1(display_short)|uniprotkb:CROC1(gene name synonym)|uniprotkb:UBE2V(gene name synonym)|uniprotkb:UEV1(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9972538|imex:IM-22822-115	author-confidence:Z-score = 10.77	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:620966|refseq:NP_446339.1|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR007527(Zinc finger, SWIM-type)|go:"GO:0000165"(MAPK cascade)|interpro:IPR016024(Armadillo-type fold)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0002011"(morphogenesis of an epithelial sheet)|go:"GO:0003382"(epithelial cell morphogenesis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004706"(JUN kinase kinase kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007254"(JNK cascade)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008432"(JUN kinase binding)|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0016020"(membrane)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0031434"(mitogen-activated protein kinase kinase binding)|go:"GO:0031941"(filamentous actin)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0042060"(wound healing)|go:"GO:0043010"(camera-type eye development)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046625"(sphingolipid binding)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050434"(positive regulation of viral transcription)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0061029"(eyelid development in camera-type eye)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|reactome:R-RNO-166058|reactome:R-RNO-2871796|reactome:R-RNO-975138|reactome:R-RNO-975871|interpro:IPR011989(Armadillo-like helical)|mint:Q62925	refseq:NP_001027459.1|refseq:NP_068823.2|refseq:NP_071887.1|refseq:NP_954595.1|refseq:NP_954673.1|refseq:NP_001244322.1|refseq:NP_001244323.1|refseq:NP_001244325.1|ensembl:ENSG00000244687(gene)|ensembl:ENST00000371674(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006282"(regulation of DNA repair)|go:"GO:0006301"(postreplication repair)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0030154"(cell differentiation)|go:"GO:0031371"(ubiquitin conjugating enzyme complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035370"(UBC13-UEV1A complex)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070534"(protein K63-linked ubiquitination)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|rcsb pdb:2A4D|rcsb pdb:2C2V|rcsb pdb:2HLW|rcsb pdb:6D6I|reactome:R-HSA-168638|reactome:R-HSA-168927|reactome:R-HSA-202424|reactome:R-HSA-2871837|reactome:R-HSA-445989|reactome:R-HSA-450302|reactome:R-HSA-450321|reactome:R-HSA-5607764|reactome:R-HSA-9020702|reactome:R-HSA-937039|reactome:R-HSA-937041|reactome:R-HSA-9646399|reactome:R-HSA-975110|reactome:R-HSA-975144|reactome:R-HSA-983168|dip:DIP-41911N	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S3|resulting-ptm:Q9BSL1 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:EwhjYjowkZIAt4UyPcZBUtf9uak10116	rogid:x95N7Dj2KIqu5gySX59xLmfthUg9606	intact-crc:9E6584B49A975E22|rigid:rPBJPyVsUXtSiTlSHZZJgKo2NY8	false	sufficient binding region:433-481(IPR013083)	his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q62925	uniprotkb:P22314	intact:EBI-636664	intact:EBI-709688|uniprotkb:Q96E13|uniprotkb:Q5JRR8|ensembl:ENSP00000338413|ensembl:ENSP00000366568	psi-mi:m3k1_rat(display_long)|uniprotkb:MAPK/ERK kinase kinase 1(gene name synonym)|uniprotkb:Map3k1(gene name)|psi-mi:Map3k1(display_short)|uniprotkb:Mekk(gene name synonym)|uniprotkb:Mekk1(gene name synonym)	psi-mi:uba1_human(display_long)|uniprotkb:Ubiquitin-activating enzyme E1(gene name synonym)|uniprotkb:Protein A1S9(gene name synonym)|uniprotkb:UBA1(gene name)|psi-mi:UBA1(display_short)|uniprotkb:A1S9T(gene name synonym)|uniprotkb:UBE1(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9972538|imex:IM-22822-115	author-confidence:Z-score = 10.77	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:620966|refseq:NP_446339.1|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR007527(Zinc finger, SWIM-type)|go:"GO:0000165"(MAPK cascade)|interpro:IPR016024(Armadillo-type fold)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0002011"(morphogenesis of an epithelial sheet)|go:"GO:0003382"(epithelial cell morphogenesis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004706"(JUN kinase kinase kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007254"(JNK cascade)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008432"(JUN kinase binding)|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0016020"(membrane)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0031434"(mitogen-activated protein kinase kinase binding)|go:"GO:0031941"(filamentous actin)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0042060"(wound healing)|go:"GO:0043010"(camera-type eye development)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046625"(sphingolipid binding)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050434"(positive regulation of viral transcription)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0061029"(eyelid development in camera-type eye)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|reactome:R-RNO-166058|reactome:R-RNO-2871796|reactome:R-RNO-975138|reactome:R-RNO-975871|interpro:IPR011989(Armadillo-like helical)|mint:Q62925	refseq:NP_003325.2|refseq:NP_695012.1|refseq:XP_016885269.1|refseq:XP_016885270.1|dip:DIP-33686N|ensembl:ENSG00000130985(gene)|ensembl:ENST00000335972(transcript)|ensembl:ENST00000377351(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0004839"(ubiquitin activating enzyme activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0032446"(protein modification by small protein conjugation)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000011(Ubiquitin-activating enzyme, E1)|interpro:IPR000594(UBA/THIF-type NAD/FAD binding fold)|interpro:IPR018074|interpro:IPR018075|interpro:IPR018965|interpro:IPR019572|interpro:IPR032418|interpro:IPR032420|interpro:IPR033127|interpro:IPR035985|interpro:IPR038252|interpro:IPR042063|interpro:IPR042302|interpro:IPR042449|mint:P22314|rcsb pdb:4P22|rcsb pdb:6DC6|reactome:R-HSA-8866652|reactome:R-HSA-983168	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S3|resulting-ptm:Q9BSL1 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:EwhjYjowkZIAt4UyPcZBUtf9uak10116	rogid:q+vEeA0XLST0Zz173bmEt0dNbDE9606	intact-crc:9E6584B49A975E22|rigid:rPBJPyVsUXtSiTlSHZZJgKo2NY8	false	sufficient binding region:433-481(IPR013083)	his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q62925	uniprotkb:Q9BSL1	intact:EBI-636664	intact:EBI-749370|uniprotkb:O75500|uniprotkb:Q9UMW7|ensembl:ENSP00000360821	psi-mi:m3k1_rat(display_long)|uniprotkb:MAPK/ERK kinase kinase 1(gene name synonym)|uniprotkb:Map3k1(gene name)|psi-mi:Map3k1(display_short)|uniprotkb:Mekk(gene name synonym)|uniprotkb:Mekk1(gene name synonym)	psi-mi:ubac1_human(display_long)|uniprotkb:UBADC1(gene name synonym)|uniprotkb:E3 ubiquitin-protein ligase subunit KPC2(gene name synonym)|uniprotkb:Kip1 ubiquitination-promoting complex protein 2(gene name synonym)|uniprotkb:Glialblastoma cell differentiation-related protein 1(gene name synonym)|uniprotkb:UBAC1(gene name)|psi-mi:UBAC1(display_short)|uniprotkb:GBDR1(gene name synonym)|uniprotkb:KPC2(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9972538|imex:IM-22822-115	author-confidence:Z-score = 10.77	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:620966|refseq:NP_446339.1|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR007527(Zinc finger, SWIM-type)|go:"GO:0000165"(MAPK cascade)|interpro:IPR016024(Armadillo-type fold)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0002011"(morphogenesis of an epithelial sheet)|go:"GO:0003382"(epithelial cell morphogenesis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004706"(JUN kinase kinase kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007254"(JNK cascade)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008432"(JUN kinase binding)|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0016020"(membrane)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0031434"(mitogen-activated protein kinase kinase binding)|go:"GO:0031941"(filamentous actin)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0042060"(wound healing)|go:"GO:0043010"(camera-type eye development)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046625"(sphingolipid binding)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050434"(positive regulation of viral transcription)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0061029"(eyelid development in camera-type eye)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|reactome:R-RNO-166058|reactome:R-RNO-2871796|reactome:R-RNO-975138|reactome:R-RNO-975871|interpro:IPR011989(Armadillo-like helical)|mint:Q62925	refseq:NP_057256.2|dip:DIP-47279N|ensembl:ENSG00000130560(gene)|ensembl:ENST00000371756(transcript)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0070062"(extracellular exosome)|interpro:IPR006636(Heat shock chaperonin-binding)|interpro:IPR009060(UBA-like)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR029071|interpro:IPR041926|interpro:IPR041927|mint:Q9BSL1|rcsb pdb:2DAI|reactome:R-HSA-983168|go:"GO:0005886"(plasma membrane)	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S3|resulting-ptm:Q9BSL1 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:EwhjYjowkZIAt4UyPcZBUtf9uak10116	rogid:xgBRjmUpQ2UGdiEu5KQSZVy7TrQ9606	intact-crc:9E6584B49A975E22|rigid:rPBJPyVsUXtSiTlSHZZJgKo2NY8	false	sufficient binding region:433-481(IPR013083)	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q62925	uniprotkb:P61088	intact:EBI-636664	intact:EBI-1052908|uniprotkb:Q16781|uniprotkb:Q53Y81|ensembl:ENSP00000316176	psi-mi:m3k1_rat(display_long)|uniprotkb:MAPK/ERK kinase kinase 1(gene name synonym)|uniprotkb:Map3k1(gene name)|psi-mi:Map3k1(display_short)|uniprotkb:Mekk(gene name synonym)|uniprotkb:Mekk1(gene name synonym)	psi-mi:ube2n_human(display_long)|uniprotkb:Ubiquitin-protein ligase N(gene name synonym)|uniprotkb:Ubiquitin carrier protein N(gene name synonym)|uniprotkb:Ubc13(gene name synonym)|uniprotkb:Bendless-like ubiquitin-conjugating enzyme(gene name synonym)|uniprotkb:UBE2N(gene name)|psi-mi:UBE2N(display_short)|uniprotkb:BLU(gene name synonym)|uniprotkb:UbcH13(gene name synonym)|uniprotkb:E2 ubiquitin-conjugating enzyme N(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9972538|imex:IM-22822-115	author-confidence:Z-score = 10.77	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:620966|refseq:NP_446339.1|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR007527(Zinc finger, SWIM-type)|go:"GO:0000165"(MAPK cascade)|interpro:IPR016024(Armadillo-type fold)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0002011"(morphogenesis of an epithelial sheet)|go:"GO:0003382"(epithelial cell morphogenesis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004706"(JUN kinase kinase kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007254"(JNK cascade)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008432"(JUN kinase binding)|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0016020"(membrane)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0031434"(mitogen-activated protein kinase kinase binding)|go:"GO:0031941"(filamentous actin)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0042060"(wound healing)|go:"GO:0043010"(camera-type eye development)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046625"(sphingolipid binding)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050434"(positive regulation of viral transcription)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0061029"(eyelid development in camera-type eye)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|reactome:R-RNO-166058|reactome:R-RNO-2871796|reactome:R-RNO-975138|reactome:R-RNO-975871|interpro:IPR011989(Armadillo-like helical)|mint:Q62925	refseq:NP_003339.1|dip:DIP-29829N|ensembl:ENSG00000177889(gene)|ensembl:ENST00000318066(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000729"(DNA double-strand break processing)|go:"GO:0001650"(fibrillar center)|go:"GO:0003723"(RNA binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006282"(regulation of DNA repair)|go:"GO:0006301"(postreplication repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016574"(histone ubiquitination)|go:"GO:0031058"(positive regulation of histone modification)|go:"GO:0031372"(UBC13-MMS2 complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033182"(regulation of histone ubiquitination)|go:"GO:0035370"(UBC13-UEV1A complex)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0061631"(ubiquitin conjugating enzyme activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070534"(protein K63-linked ubiquitination)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|interpro:IPR023313|rcsb pdb:1J7D|rcsb pdb:2C2V|rcsb pdb:3HCT|rcsb pdb:3HCU|rcsb pdb:3VON|rcsb pdb:3W31|rcsb pdb:4DHI|rcsb pdb:4DHJ|rcsb pdb:4DHZ|rcsb pdb:4IP3|rcsb pdb:4NR3|rcsb pdb:4NRG|rcsb pdb:4NRI|rcsb pdb:4ONL|rcsb pdb:4ONM|rcsb pdb:4ONN|rcsb pdb:4ORH|rcsb pdb:4TKP|rcsb pdb:4WHV|rcsb pdb:5AIT|rcsb pdb:5AIU|rcsb pdb:5EYA|rcsb pdb:5H7S|rcsb pdb:5VNZ|rcsb pdb:5VO0|rcsb pdb:5YWR|rcsb pdb:6D6I|rcsb pdb:6JKY|rcsb pdb:6KFP|rcsb pdb:6KG6|rcsb pdb:6KL4|rcsb pdb:6LP2|rcsb pdb:6P5B|rcsb pdb:6S53|reactome:R-HSA-168927|reactome:R-HSA-202424|reactome:R-HSA-2871837|reactome:R-HSA-445989|reactome:R-HSA-450302|reactome:R-HSA-450321|reactome:R-HSA-5607764|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-5696395|reactome:R-HSA-69473|reactome:R-HSA-8866654|reactome:R-HSA-9020702|reactome:R-HSA-937039|reactome:R-HSA-937041|reactome:R-HSA-9646399|reactome:R-HSA-975110|reactome:R-HSA-975144|reactome:R-HSA-983168|rcsb pdb:6ULH|rcsb pdb:6UMP|rcsb pdb:6UMS|rcsb pdb:7BBD|rcsb pdb:7BBF|rcsb pdb:7BXG|reactome:R-HSA-1169408|reactome:R-HSA-168638	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S3|resulting-ptm:Q9BSL1 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:EwhjYjowkZIAt4UyPcZBUtf9uak10116	rogid:dqdszHlq5FLPHC6UWX6uvkC6Yz89606	intact-crc:9E6584B49A975E22|rigid:rPBJPyVsUXtSiTlSHZZJgKo2NY8	false	sufficient binding region:433-481(IPR013083)	his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9BXL6	uniprotkb:Q62925	intact:EBI-745552|uniprotkb:Q9BVB5|ensembl:ENSP00000344549|ensembl:ENSP00000458715|ensembl:ENSP00000498071|uniprotkb:B8QQJ3	intact:EBI-636664	psi-mi:car14_human(display_long)|uniprotkb:CARD-containing MAGUK protein 2(gene name synonym)|uniprotkb:CARD14(gene name)|psi-mi:CARD14(display_short)|uniprotkb:CARMA2(gene name synonym)	psi-mi:m3k1_rat(display_long)|uniprotkb:MAPK/ERK kinase kinase 1(gene name synonym)|uniprotkb:Map3k1(gene name)|psi-mi:Map3k1(display_short)|uniprotkb:Mekk(gene name synonym)|uniprotkb:Mekk1(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9972588|imex:IM-22822-117	author-confidence:Z-score = 3.39	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_077015.2|refseq:NP_438170.1|refseq:XP_011523514.1|refseq:XP_011523515.1|refseq:XP_011523517.1|refseq:XP_011523518.1|refseq:XP_011523519.1|refseq:XP_011523520.1|ensembl:ENSG00000141527(gene)|ensembl:ENST00000344227(transcript)|ensembl:ENST00000573882(transcript)|ensembl:ENST00000648509(transcript)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0007250"(activation of NF-kappaB-inducing kinase activity)|go:"GO:0016235"(aggresome)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0050700"(CARD domain binding)|interpro:IPR001315(Caspase Recruitment)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR008144(Guanylate kinase)|interpro:IPR011029(DEATH-like)|interpro:IPR027417|interpro:IPR036034|refseq:NP_001244899.1	rgd:620966|refseq:NP_446339.1|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR007527(Zinc finger, SWIM-type)|go:"GO:0000165"(MAPK cascade)|interpro:IPR016024(Armadillo-type fold)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0002011"(morphogenesis of an epithelial sheet)|go:"GO:0003382"(epithelial cell morphogenesis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004706"(JUN kinase kinase kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007254"(JNK cascade)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008432"(JUN kinase binding)|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0016020"(membrane)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0031434"(mitogen-activated protein kinase kinase binding)|go:"GO:0031941"(filamentous actin)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0042060"(wound healing)|go:"GO:0043010"(camera-type eye development)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046625"(sphingolipid binding)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050434"(positive regulation of viral transcription)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0061029"(eyelid development in camera-type eye)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|reactome:R-RNO-166058|reactome:R-RNO-2871796|reactome:R-RNO-975138|reactome:R-RNO-975871|interpro:IPR011989(Armadillo-like helical)|mint:Q62925	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S3|resulting-ptm:Q9BXL6 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:cAs16S4RBurF3R0v4W9EhnkdCKU9606	rogid:EwhjYjowkZIAt4UyPcZBUtf9uak10116	intact-crc:D6105263060CE3AD|rigid:HB8h06QsuKPwwm/tFubooOHmeeA	false	-	sufficient binding region:433-481(IPR013083)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9BXL6	uniprotkb:Q13404	intact:EBI-745552|uniprotkb:Q9BVB5|ensembl:ENSP00000344549|ensembl:ENSP00000458715|ensembl:ENSP00000498071|uniprotkb:B8QQJ3	intact:EBI-1050671|uniprotkb:Q13403|uniprotkb:Q13532|uniprotkb:Q96H34|uniprotkb:Q9GZT0|uniprotkb:Q9GZW1|uniprotkb:Q9H4J3|uniprotkb:Q9H4J4|uniprotkb:Q9UKL1|uniprotkb:Q9UM48|uniprotkb:Q9UM49|uniprotkb:Q9UM50|uniprotkb:Q5TGE3|uniprotkb:E1P629|uniprotkb:Q5TGE0|ensembl:ENSP00000360739	psi-mi:car14_human(display_long)|uniprotkb:CARD-containing MAGUK protein 2(gene name synonym)|uniprotkb:CARD14(gene name)|psi-mi:CARD14(display_short)|uniprotkb:CARMA2(gene name synonym)	psi-mi:ub2v1_human(display_long)|uniprotkb:CROC-1(gene name synonym)|uniprotkb:TRAF6-regulated IKK activator 1 beta Uev1A(gene name synonym)|uniprotkb:P/OKcl.19(orf name)|uniprotkb:UBE2V1(gene name)|psi-mi:UBE2V1(display_short)|uniprotkb:CROC1(gene name synonym)|uniprotkb:UBE2V(gene name synonym)|uniprotkb:UEV1(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9972588|imex:IM-22822-117	author-confidence:Z-score = 3.39	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_077015.2|refseq:NP_438170.1|refseq:XP_011523514.1|refseq:XP_011523515.1|refseq:XP_011523517.1|refseq:XP_011523518.1|refseq:XP_011523519.1|refseq:XP_011523520.1|ensembl:ENSG00000141527(gene)|ensembl:ENST00000344227(transcript)|ensembl:ENST00000573882(transcript)|ensembl:ENST00000648509(transcript)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0007250"(activation of NF-kappaB-inducing kinase activity)|go:"GO:0016235"(aggresome)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0050700"(CARD domain binding)|interpro:IPR001315(Caspase Recruitment)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR008144(Guanylate kinase)|interpro:IPR011029(DEATH-like)|interpro:IPR027417|interpro:IPR036034|refseq:NP_001244899.1	refseq:NP_001027459.1|refseq:NP_068823.2|refseq:NP_071887.1|refseq:NP_954595.1|refseq:NP_954673.1|refseq:NP_001244322.1|refseq:NP_001244323.1|refseq:NP_001244325.1|ensembl:ENSG00000244687(gene)|ensembl:ENST00000371674(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006282"(regulation of DNA repair)|go:"GO:0006301"(postreplication repair)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0030154"(cell differentiation)|go:"GO:0031371"(ubiquitin conjugating enzyme complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035370"(UBC13-UEV1A complex)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070534"(protein K63-linked ubiquitination)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|rcsb pdb:2A4D|rcsb pdb:2C2V|rcsb pdb:2HLW|rcsb pdb:6D6I|reactome:R-HSA-168638|reactome:R-HSA-168927|reactome:R-HSA-202424|reactome:R-HSA-2871837|reactome:R-HSA-445989|reactome:R-HSA-450302|reactome:R-HSA-450321|reactome:R-HSA-5607764|reactome:R-HSA-9020702|reactome:R-HSA-937039|reactome:R-HSA-937041|reactome:R-HSA-9646399|reactome:R-HSA-975110|reactome:R-HSA-975144|reactome:R-HSA-983168|dip:DIP-41911N	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S3|resulting-ptm:Q9BXL6 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:cAs16S4RBurF3R0v4W9EhnkdCKU9606	rogid:x95N7Dj2KIqu5gySX59xLmfthUg9606	intact-crc:D6105263060CE3AD|rigid:HB8h06QsuKPwwm/tFubooOHmeeA	false	-	his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9BXL6	uniprotkb:P22314	intact:EBI-745552|uniprotkb:Q9BVB5|ensembl:ENSP00000344549|ensembl:ENSP00000458715|ensembl:ENSP00000498071|uniprotkb:B8QQJ3	intact:EBI-709688|uniprotkb:Q96E13|uniprotkb:Q5JRR8|ensembl:ENSP00000338413|ensembl:ENSP00000366568	psi-mi:car14_human(display_long)|uniprotkb:CARD-containing MAGUK protein 2(gene name synonym)|uniprotkb:CARD14(gene name)|psi-mi:CARD14(display_short)|uniprotkb:CARMA2(gene name synonym)	psi-mi:uba1_human(display_long)|uniprotkb:Ubiquitin-activating enzyme E1(gene name synonym)|uniprotkb:Protein A1S9(gene name synonym)|uniprotkb:UBA1(gene name)|psi-mi:UBA1(display_short)|uniprotkb:A1S9T(gene name synonym)|uniprotkb:UBE1(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9972588|imex:IM-22822-117	author-confidence:Z-score = 3.39	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_077015.2|refseq:NP_438170.1|refseq:XP_011523514.1|refseq:XP_011523515.1|refseq:XP_011523517.1|refseq:XP_011523518.1|refseq:XP_011523519.1|refseq:XP_011523520.1|ensembl:ENSG00000141527(gene)|ensembl:ENST00000344227(transcript)|ensembl:ENST00000573882(transcript)|ensembl:ENST00000648509(transcript)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0007250"(activation of NF-kappaB-inducing kinase activity)|go:"GO:0016235"(aggresome)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0050700"(CARD domain binding)|interpro:IPR001315(Caspase Recruitment)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR008144(Guanylate kinase)|interpro:IPR011029(DEATH-like)|interpro:IPR027417|interpro:IPR036034|refseq:NP_001244899.1	refseq:NP_003325.2|refseq:NP_695012.1|refseq:XP_016885269.1|refseq:XP_016885270.1|dip:DIP-33686N|ensembl:ENSG00000130985(gene)|ensembl:ENST00000335972(transcript)|ensembl:ENST00000377351(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0004839"(ubiquitin activating enzyme activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0032446"(protein modification by small protein conjugation)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000011(Ubiquitin-activating enzyme, E1)|interpro:IPR000594(UBA/THIF-type NAD/FAD binding fold)|interpro:IPR018074|interpro:IPR018075|interpro:IPR018965|interpro:IPR019572|interpro:IPR032418|interpro:IPR032420|interpro:IPR033127|interpro:IPR035985|interpro:IPR038252|interpro:IPR042063|interpro:IPR042302|interpro:IPR042449|mint:P22314|rcsb pdb:4P22|rcsb pdb:6DC6|reactome:R-HSA-8866652|reactome:R-HSA-983168	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S3|resulting-ptm:Q9BXL6 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:cAs16S4RBurF3R0v4W9EhnkdCKU9606	rogid:q+vEeA0XLST0Zz173bmEt0dNbDE9606	intact-crc:D6105263060CE3AD|rigid:HB8h06QsuKPwwm/tFubooOHmeeA	false	-	his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9BXL6	uniprotkb:P61088	intact:EBI-745552|uniprotkb:Q9BVB5|ensembl:ENSP00000344549|ensembl:ENSP00000458715|ensembl:ENSP00000498071|uniprotkb:B8QQJ3	intact:EBI-1052908|uniprotkb:Q16781|uniprotkb:Q53Y81|ensembl:ENSP00000316176	psi-mi:car14_human(display_long)|uniprotkb:CARD-containing MAGUK protein 2(gene name synonym)|uniprotkb:CARD14(gene name)|psi-mi:CARD14(display_short)|uniprotkb:CARMA2(gene name synonym)	psi-mi:ube2n_human(display_long)|uniprotkb:Ubiquitin-protein ligase N(gene name synonym)|uniprotkb:Ubiquitin carrier protein N(gene name synonym)|uniprotkb:Ubc13(gene name synonym)|uniprotkb:Bendless-like ubiquitin-conjugating enzyme(gene name synonym)|uniprotkb:UBE2N(gene name)|psi-mi:UBE2N(display_short)|uniprotkb:BLU(gene name synonym)|uniprotkb:UbcH13(gene name synonym)|uniprotkb:E2 ubiquitin-conjugating enzyme N(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9972588|imex:IM-22822-117	author-confidence:Z-score = 3.39	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_077015.2|refseq:NP_438170.1|refseq:XP_011523514.1|refseq:XP_011523515.1|refseq:XP_011523517.1|refseq:XP_011523518.1|refseq:XP_011523519.1|refseq:XP_011523520.1|ensembl:ENSG00000141527(gene)|ensembl:ENST00000344227(transcript)|ensembl:ENST00000573882(transcript)|ensembl:ENST00000648509(transcript)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0007250"(activation of NF-kappaB-inducing kinase activity)|go:"GO:0016235"(aggresome)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0050700"(CARD domain binding)|interpro:IPR001315(Caspase Recruitment)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR008144(Guanylate kinase)|interpro:IPR011029(DEATH-like)|interpro:IPR027417|interpro:IPR036034|refseq:NP_001244899.1	refseq:NP_003339.1|dip:DIP-29829N|ensembl:ENSG00000177889(gene)|ensembl:ENST00000318066(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000729"(DNA double-strand break processing)|go:"GO:0001650"(fibrillar center)|go:"GO:0003723"(RNA binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006282"(regulation of DNA repair)|go:"GO:0006301"(postreplication repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016574"(histone ubiquitination)|go:"GO:0031058"(positive regulation of histone modification)|go:"GO:0031372"(UBC13-MMS2 complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033182"(regulation of histone ubiquitination)|go:"GO:0035370"(UBC13-UEV1A complex)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0061631"(ubiquitin conjugating enzyme activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070534"(protein K63-linked ubiquitination)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|interpro:IPR023313|rcsb pdb:1J7D|rcsb pdb:2C2V|rcsb pdb:3HCT|rcsb pdb:3HCU|rcsb pdb:3VON|rcsb pdb:3W31|rcsb pdb:4DHI|rcsb pdb:4DHJ|rcsb pdb:4DHZ|rcsb pdb:4IP3|rcsb pdb:4NR3|rcsb pdb:4NRG|rcsb pdb:4NRI|rcsb pdb:4ONL|rcsb pdb:4ONM|rcsb pdb:4ONN|rcsb pdb:4ORH|rcsb pdb:4TKP|rcsb pdb:4WHV|rcsb pdb:5AIT|rcsb pdb:5AIU|rcsb pdb:5EYA|rcsb pdb:5H7S|rcsb pdb:5VNZ|rcsb pdb:5VO0|rcsb pdb:5YWR|rcsb pdb:6D6I|rcsb pdb:6JKY|rcsb pdb:6KFP|rcsb pdb:6KG6|rcsb pdb:6KL4|rcsb pdb:6LP2|rcsb pdb:6P5B|rcsb pdb:6S53|reactome:R-HSA-168927|reactome:R-HSA-202424|reactome:R-HSA-2871837|reactome:R-HSA-445989|reactome:R-HSA-450302|reactome:R-HSA-450321|reactome:R-HSA-5607764|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-5696395|reactome:R-HSA-69473|reactome:R-HSA-8866654|reactome:R-HSA-9020702|reactome:R-HSA-937039|reactome:R-HSA-937041|reactome:R-HSA-9646399|reactome:R-HSA-975110|reactome:R-HSA-975144|reactome:R-HSA-983168|rcsb pdb:6ULH|rcsb pdb:6UMP|rcsb pdb:6UMS|rcsb pdb:7BBD|rcsb pdb:7BBF|rcsb pdb:7BXG|reactome:R-HSA-1169408|reactome:R-HSA-168638	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S3|resulting-ptm:Q9BXL6 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:cAs16S4RBurF3R0v4W9EhnkdCKU9606	rogid:dqdszHlq5FLPHC6UWX6uvkC6Yz89606	intact-crc:D6105263060CE3AD|rigid:HB8h06QsuKPwwm/tFubooOHmeeA	false	-	his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9BYM8	uniprotkb:Q62925	intact:EBI-2340624|uniprotkb:O95623|uniprotkb:Q9BYM9|uniprotkb:Q96BS3|uniprotkb:Q86SL2|ensembl:ENSP00000348632	intact:EBI-636664	psi-mi:hoil1_human(display_long)|uniprotkb:RBCK1(gene name)|psi-mi:RBCK1(display_short)|uniprotkb:C20orf18(gene name synonym)|uniprotkb:RNF54(gene name synonym)|uniprotkb:UBCE7IP3(gene name synonym)|uniprotkb:XAP3(gene name synonym)|uniprotkb:XAP4(gene name synonym)|uniprotkb:Ubiquitin-conjugating enzyme 7-interacting protein 3(gene name synonym)|uniprotkb:Hepatitis B virus X-associated protein 4(gene name synonym)|uniprotkb:HBV-associated factor 4(gene name synonym)|uniprotkb:RING finger protein 54(gene name synonym)|uniprotkb:Heme-oxidized IRP2 ubiquitin ligase 1(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase HOIL-1(gene name synonym)	psi-mi:m3k1_rat(display_long)|uniprotkb:MAPK/ERK kinase kinase 1(gene name synonym)|uniprotkb:Map3k1(gene name)|psi-mi:Map3k1(display_short)|uniprotkb:Mekk(gene name synonym)|uniprotkb:Mekk1(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9972613|imex:IM-22822-118	author-confidence:Z-score = 4.05	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_006453.1|refseq:NP_112506.2|ensembl:ENSG00000125826(gene)|ensembl:ENST00000356286(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005829"(cytosol)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051220"(cytoplasmic sequestering of protein)|go:"GO:0060546"(negative regulation of necroptotic process)|go:"GO:0071797"(LUBAC complex)|go:"GO:0097039"(protein linear polyubiquitination)|go:"GO:0140311"(protein sequestering activity)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|interpro:IPR000626(Ubiquitin)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR001876(Zinc finger, RanBP2-type)|interpro:IPR002867(Zinc finger, C6HC-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR026261|interpro:IPR027370|interpro:IPR029071|interpro:IPR036443|interpro:IPR044066|mint:Q9BYM8|rcsb pdb:2CRC|rcsb pdb:2LGY|rcsb pdb:4DBG|reactome:R-HSA-5357905|reactome:R-HSA-5357956|reactome:R-HSA-983168|dip:DIP-47737N	rgd:620966|refseq:NP_446339.1|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR007527(Zinc finger, SWIM-type)|go:"GO:0000165"(MAPK cascade)|interpro:IPR016024(Armadillo-type fold)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0002011"(morphogenesis of an epithelial sheet)|go:"GO:0003382"(epithelial cell morphogenesis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004706"(JUN kinase kinase kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007254"(JNK cascade)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008432"(JUN kinase binding)|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0016020"(membrane)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0031434"(mitogen-activated protein kinase kinase binding)|go:"GO:0031941"(filamentous actin)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0042060"(wound healing)|go:"GO:0043010"(camera-type eye development)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046625"(sphingolipid binding)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050434"(positive regulation of viral transcription)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0061029"(eyelid development in camera-type eye)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|reactome:R-RNO-166058|reactome:R-RNO-2871796|reactome:R-RNO-975138|reactome:R-RNO-975871|interpro:IPR011989(Armadillo-like helical)|mint:Q62925	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S3|resulting-ptm:Q9BYM8 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:TrkfR++u4X4c/KzUlC5Mcu6SgVs9606	rogid:EwhjYjowkZIAt4UyPcZBUtf9uak10116	intact-crc:6007A5ADB3993FB9|rigid:q7DYpMflz3s+46r1tTw5kkcanLA	false	-	sufficient binding region:433-481(IPR013083)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9BYM8	uniprotkb:Q13404	intact:EBI-2340624|uniprotkb:O95623|uniprotkb:Q9BYM9|uniprotkb:Q96BS3|uniprotkb:Q86SL2|ensembl:ENSP00000348632	intact:EBI-1050671|uniprotkb:Q13403|uniprotkb:Q13532|uniprotkb:Q96H34|uniprotkb:Q9GZT0|uniprotkb:Q9GZW1|uniprotkb:Q9H4J3|uniprotkb:Q9H4J4|uniprotkb:Q9UKL1|uniprotkb:Q9UM48|uniprotkb:Q9UM49|uniprotkb:Q9UM50|uniprotkb:Q5TGE3|uniprotkb:E1P629|uniprotkb:Q5TGE0|ensembl:ENSP00000360739	psi-mi:hoil1_human(display_long)|uniprotkb:RBCK1(gene name)|psi-mi:RBCK1(display_short)|uniprotkb:C20orf18(gene name synonym)|uniprotkb:RNF54(gene name synonym)|uniprotkb:UBCE7IP3(gene name synonym)|uniprotkb:XAP3(gene name synonym)|uniprotkb:XAP4(gene name synonym)|uniprotkb:Ubiquitin-conjugating enzyme 7-interacting protein 3(gene name synonym)|uniprotkb:Hepatitis B virus X-associated protein 4(gene name synonym)|uniprotkb:HBV-associated factor 4(gene name synonym)|uniprotkb:RING finger protein 54(gene name synonym)|uniprotkb:Heme-oxidized IRP2 ubiquitin ligase 1(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase HOIL-1(gene name synonym)	psi-mi:ub2v1_human(display_long)|uniprotkb:CROC-1(gene name synonym)|uniprotkb:TRAF6-regulated IKK activator 1 beta Uev1A(gene name synonym)|uniprotkb:P/OKcl.19(orf name)|uniprotkb:UBE2V1(gene name)|psi-mi:UBE2V1(display_short)|uniprotkb:CROC1(gene name synonym)|uniprotkb:UBE2V(gene name synonym)|uniprotkb:UEV1(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9972613|imex:IM-22822-118	author-confidence:Z-score = 4.05	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_006453.1|refseq:NP_112506.2|ensembl:ENSG00000125826(gene)|ensembl:ENST00000356286(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005829"(cytosol)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051220"(cytoplasmic sequestering of protein)|go:"GO:0060546"(negative regulation of necroptotic process)|go:"GO:0071797"(LUBAC complex)|go:"GO:0097039"(protein linear polyubiquitination)|go:"GO:0140311"(protein sequestering activity)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|interpro:IPR000626(Ubiquitin)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR001876(Zinc finger, RanBP2-type)|interpro:IPR002867(Zinc finger, C6HC-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR026261|interpro:IPR027370|interpro:IPR029071|interpro:IPR036443|interpro:IPR044066|mint:Q9BYM8|rcsb pdb:2CRC|rcsb pdb:2LGY|rcsb pdb:4DBG|reactome:R-HSA-5357905|reactome:R-HSA-5357956|reactome:R-HSA-983168|dip:DIP-47737N	refseq:NP_001027459.1|refseq:NP_068823.2|refseq:NP_071887.1|refseq:NP_954595.1|refseq:NP_954673.1|refseq:NP_001244322.1|refseq:NP_001244323.1|refseq:NP_001244325.1|ensembl:ENSG00000244687(gene)|ensembl:ENST00000371674(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006282"(regulation of DNA repair)|go:"GO:0006301"(postreplication repair)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0030154"(cell differentiation)|go:"GO:0031371"(ubiquitin conjugating enzyme complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035370"(UBC13-UEV1A complex)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070534"(protein K63-linked ubiquitination)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|rcsb pdb:2A4D|rcsb pdb:2C2V|rcsb pdb:2HLW|rcsb pdb:6D6I|reactome:R-HSA-168638|reactome:R-HSA-168927|reactome:R-HSA-202424|reactome:R-HSA-2871837|reactome:R-HSA-445989|reactome:R-HSA-450302|reactome:R-HSA-450321|reactome:R-HSA-5607764|reactome:R-HSA-9020702|reactome:R-HSA-937039|reactome:R-HSA-937041|reactome:R-HSA-9646399|reactome:R-HSA-975110|reactome:R-HSA-975144|reactome:R-HSA-983168|dip:DIP-41911N	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S3|resulting-ptm:Q9BYM8 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:TrkfR++u4X4c/KzUlC5Mcu6SgVs9606	rogid:x95N7Dj2KIqu5gySX59xLmfthUg9606	intact-crc:6007A5ADB3993FB9|rigid:q7DYpMflz3s+46r1tTw5kkcanLA	false	-	his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9BYM8	uniprotkb:P22314	intact:EBI-2340624|uniprotkb:O95623|uniprotkb:Q9BYM9|uniprotkb:Q96BS3|uniprotkb:Q86SL2|ensembl:ENSP00000348632	intact:EBI-709688|uniprotkb:Q96E13|uniprotkb:Q5JRR8|ensembl:ENSP00000338413|ensembl:ENSP00000366568	psi-mi:hoil1_human(display_long)|uniprotkb:RBCK1(gene name)|psi-mi:RBCK1(display_short)|uniprotkb:C20orf18(gene name synonym)|uniprotkb:RNF54(gene name synonym)|uniprotkb:UBCE7IP3(gene name synonym)|uniprotkb:XAP3(gene name synonym)|uniprotkb:XAP4(gene name synonym)|uniprotkb:Ubiquitin-conjugating enzyme 7-interacting protein 3(gene name synonym)|uniprotkb:Hepatitis B virus X-associated protein 4(gene name synonym)|uniprotkb:HBV-associated factor 4(gene name synonym)|uniprotkb:RING finger protein 54(gene name synonym)|uniprotkb:Heme-oxidized IRP2 ubiquitin ligase 1(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase HOIL-1(gene name synonym)	psi-mi:uba1_human(display_long)|uniprotkb:Ubiquitin-activating enzyme E1(gene name synonym)|uniprotkb:Protein A1S9(gene name synonym)|uniprotkb:UBA1(gene name)|psi-mi:UBA1(display_short)|uniprotkb:A1S9T(gene name synonym)|uniprotkb:UBE1(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9972613|imex:IM-22822-118	author-confidence:Z-score = 4.05	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_006453.1|refseq:NP_112506.2|ensembl:ENSG00000125826(gene)|ensembl:ENST00000356286(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005829"(cytosol)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051220"(cytoplasmic sequestering of protein)|go:"GO:0060546"(negative regulation of necroptotic process)|go:"GO:0071797"(LUBAC complex)|go:"GO:0097039"(protein linear polyubiquitination)|go:"GO:0140311"(protein sequestering activity)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|interpro:IPR000626(Ubiquitin)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR001876(Zinc finger, RanBP2-type)|interpro:IPR002867(Zinc finger, C6HC-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR026261|interpro:IPR027370|interpro:IPR029071|interpro:IPR036443|interpro:IPR044066|mint:Q9BYM8|rcsb pdb:2CRC|rcsb pdb:2LGY|rcsb pdb:4DBG|reactome:R-HSA-5357905|reactome:R-HSA-5357956|reactome:R-HSA-983168|dip:DIP-47737N	refseq:NP_003325.2|refseq:NP_695012.1|refseq:XP_016885269.1|refseq:XP_016885270.1|dip:DIP-33686N|ensembl:ENSG00000130985(gene)|ensembl:ENST00000335972(transcript)|ensembl:ENST00000377351(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0004839"(ubiquitin activating enzyme activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0032446"(protein modification by small protein conjugation)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000011(Ubiquitin-activating enzyme, E1)|interpro:IPR000594(UBA/THIF-type NAD/FAD binding fold)|interpro:IPR018074|interpro:IPR018075|interpro:IPR018965|interpro:IPR019572|interpro:IPR032418|interpro:IPR032420|interpro:IPR033127|interpro:IPR035985|interpro:IPR038252|interpro:IPR042063|interpro:IPR042302|interpro:IPR042449|mint:P22314|rcsb pdb:4P22|rcsb pdb:6DC6|reactome:R-HSA-8866652|reactome:R-HSA-983168	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S3|resulting-ptm:Q9BYM8 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:TrkfR++u4X4c/KzUlC5Mcu6SgVs9606	rogid:q+vEeA0XLST0Zz173bmEt0dNbDE9606	intact-crc:6007A5ADB3993FB9|rigid:q7DYpMflz3s+46r1tTw5kkcanLA	false	-	his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9BYM8	uniprotkb:P61088	intact:EBI-2340624|uniprotkb:O95623|uniprotkb:Q9BYM9|uniprotkb:Q96BS3|uniprotkb:Q86SL2|ensembl:ENSP00000348632	intact:EBI-1052908|uniprotkb:Q16781|uniprotkb:Q53Y81|ensembl:ENSP00000316176	psi-mi:hoil1_human(display_long)|uniprotkb:RBCK1(gene name)|psi-mi:RBCK1(display_short)|uniprotkb:C20orf18(gene name synonym)|uniprotkb:RNF54(gene name synonym)|uniprotkb:UBCE7IP3(gene name synonym)|uniprotkb:XAP3(gene name synonym)|uniprotkb:XAP4(gene name synonym)|uniprotkb:Ubiquitin-conjugating enzyme 7-interacting protein 3(gene name synonym)|uniprotkb:Hepatitis B virus X-associated protein 4(gene name synonym)|uniprotkb:HBV-associated factor 4(gene name synonym)|uniprotkb:RING finger protein 54(gene name synonym)|uniprotkb:Heme-oxidized IRP2 ubiquitin ligase 1(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase HOIL-1(gene name synonym)	psi-mi:ube2n_human(display_long)|uniprotkb:Ubiquitin-protein ligase N(gene name synonym)|uniprotkb:Ubiquitin carrier protein N(gene name synonym)|uniprotkb:Ubc13(gene name synonym)|uniprotkb:Bendless-like ubiquitin-conjugating enzyme(gene name synonym)|uniprotkb:UBE2N(gene name)|psi-mi:UBE2N(display_short)|uniprotkb:BLU(gene name synonym)|uniprotkb:UbcH13(gene name synonym)|uniprotkb:E2 ubiquitin-conjugating enzyme N(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9972613|imex:IM-22822-118	author-confidence:Z-score = 4.05	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_006453.1|refseq:NP_112506.2|ensembl:ENSG00000125826(gene)|ensembl:ENST00000356286(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005829"(cytosol)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051220"(cytoplasmic sequestering of protein)|go:"GO:0060546"(negative regulation of necroptotic process)|go:"GO:0071797"(LUBAC complex)|go:"GO:0097039"(protein linear polyubiquitination)|go:"GO:0140311"(protein sequestering activity)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|interpro:IPR000626(Ubiquitin)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR001876(Zinc finger, RanBP2-type)|interpro:IPR002867(Zinc finger, C6HC-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR026261|interpro:IPR027370|interpro:IPR029071|interpro:IPR036443|interpro:IPR044066|mint:Q9BYM8|rcsb pdb:2CRC|rcsb pdb:2LGY|rcsb pdb:4DBG|reactome:R-HSA-5357905|reactome:R-HSA-5357956|reactome:R-HSA-983168|dip:DIP-47737N	refseq:NP_003339.1|dip:DIP-29829N|ensembl:ENSG00000177889(gene)|ensembl:ENST00000318066(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000729"(DNA double-strand break processing)|go:"GO:0001650"(fibrillar center)|go:"GO:0003723"(RNA binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006282"(regulation of DNA repair)|go:"GO:0006301"(postreplication repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016574"(histone ubiquitination)|go:"GO:0031058"(positive regulation of histone modification)|go:"GO:0031372"(UBC13-MMS2 complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033182"(regulation of histone ubiquitination)|go:"GO:0035370"(UBC13-UEV1A complex)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0061631"(ubiquitin conjugating enzyme activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070534"(protein K63-linked ubiquitination)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|interpro:IPR023313|rcsb pdb:1J7D|rcsb pdb:2C2V|rcsb pdb:3HCT|rcsb pdb:3HCU|rcsb pdb:3VON|rcsb pdb:3W31|rcsb pdb:4DHI|rcsb pdb:4DHJ|rcsb pdb:4DHZ|rcsb pdb:4IP3|rcsb pdb:4NR3|rcsb pdb:4NRG|rcsb pdb:4NRI|rcsb pdb:4ONL|rcsb pdb:4ONM|rcsb pdb:4ONN|rcsb pdb:4ORH|rcsb pdb:4TKP|rcsb pdb:4WHV|rcsb pdb:5AIT|rcsb pdb:5AIU|rcsb pdb:5EYA|rcsb pdb:5H7S|rcsb pdb:5VNZ|rcsb pdb:5VO0|rcsb pdb:5YWR|rcsb pdb:6D6I|rcsb pdb:6JKY|rcsb pdb:6KFP|rcsb pdb:6KG6|rcsb pdb:6KL4|rcsb pdb:6LP2|rcsb pdb:6P5B|rcsb pdb:6S53|reactome:R-HSA-168927|reactome:R-HSA-202424|reactome:R-HSA-2871837|reactome:R-HSA-445989|reactome:R-HSA-450302|reactome:R-HSA-450321|reactome:R-HSA-5607764|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-5696395|reactome:R-HSA-69473|reactome:R-HSA-8866654|reactome:R-HSA-9020702|reactome:R-HSA-937039|reactome:R-HSA-937041|reactome:R-HSA-9646399|reactome:R-HSA-975110|reactome:R-HSA-975144|reactome:R-HSA-983168|rcsb pdb:6ULH|rcsb pdb:6UMP|rcsb pdb:6UMS|rcsb pdb:7BBD|rcsb pdb:7BBF|rcsb pdb:7BXG|reactome:R-HSA-1169408|reactome:R-HSA-168638	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S3|resulting-ptm:Q9BYM8 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:TrkfR++u4X4c/KzUlC5Mcu6SgVs9606	rogid:dqdszHlq5FLPHC6UWX6uvkC6Yz89606	intact-crc:6007A5ADB3993FB9|rigid:q7DYpMflz3s+46r1tTw5kkcanLA	false	-	his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q62925	uniprotkb:Q13404	intact:EBI-636664	intact:EBI-1050671|uniprotkb:Q13403|uniprotkb:Q13532|uniprotkb:Q96H34|uniprotkb:Q9GZT0|uniprotkb:Q9GZW1|uniprotkb:Q9H4J3|uniprotkb:Q9H4J4|uniprotkb:Q9UKL1|uniprotkb:Q9UM48|uniprotkb:Q9UM49|uniprotkb:Q9UM50|uniprotkb:Q5TGE3|uniprotkb:E1P629|uniprotkb:Q5TGE0|ensembl:ENSP00000360739	psi-mi:m3k1_rat(display_long)|uniprotkb:MAPK/ERK kinase kinase 1(gene name synonym)|uniprotkb:Map3k1(gene name)|psi-mi:Map3k1(display_short)|uniprotkb:Mekk(gene name synonym)|uniprotkb:Mekk1(gene name synonym)	psi-mi:ub2v1_human(display_long)|uniprotkb:CROC-1(gene name synonym)|uniprotkb:TRAF6-regulated IKK activator 1 beta Uev1A(gene name synonym)|uniprotkb:P/OKcl.19(orf name)|uniprotkb:UBE2V1(gene name)|psi-mi:UBE2V1(display_short)|uniprotkb:CROC1(gene name synonym)|uniprotkb:UBE2V(gene name synonym)|uniprotkb:UEV1(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9972638|imex:IM-22822-119	author-confidence:Z-score = 9.05|author-confidence:Z-score = 10.76	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:620966|refseq:NP_446339.1|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR007527(Zinc finger, SWIM-type)|go:"GO:0000165"(MAPK cascade)|interpro:IPR016024(Armadillo-type fold)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0002011"(morphogenesis of an epithelial sheet)|go:"GO:0003382"(epithelial cell morphogenesis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004706"(JUN kinase kinase kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007254"(JNK cascade)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008432"(JUN kinase binding)|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0016020"(membrane)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0031434"(mitogen-activated protein kinase kinase binding)|go:"GO:0031941"(filamentous actin)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0042060"(wound healing)|go:"GO:0043010"(camera-type eye development)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046625"(sphingolipid binding)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050434"(positive regulation of viral transcription)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0061029"(eyelid development in camera-type eye)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|reactome:R-RNO-166058|reactome:R-RNO-2871796|reactome:R-RNO-975138|reactome:R-RNO-975871|interpro:IPR011989(Armadillo-like helical)|mint:Q62925	refseq:NP_001027459.1|refseq:NP_068823.2|refseq:NP_071887.1|refseq:NP_954595.1|refseq:NP_954673.1|refseq:NP_001244322.1|refseq:NP_001244323.1|refseq:NP_001244325.1|ensembl:ENSG00000244687(gene)|ensembl:ENST00000371674(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006282"(regulation of DNA repair)|go:"GO:0006301"(postreplication repair)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0030154"(cell differentiation)|go:"GO:0031371"(ubiquitin conjugating enzyme complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035370"(UBC13-UEV1A complex)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070534"(protein K63-linked ubiquitination)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|rcsb pdb:2A4D|rcsb pdb:2C2V|rcsb pdb:2HLW|rcsb pdb:6D6I|reactome:R-HSA-168638|reactome:R-HSA-168927|reactome:R-HSA-202424|reactome:R-HSA-2871837|reactome:R-HSA-445989|reactome:R-HSA-450302|reactome:R-HSA-450321|reactome:R-HSA-5607764|reactome:R-HSA-9020702|reactome:R-HSA-937039|reactome:R-HSA-937041|reactome:R-HSA-9646399|reactome:R-HSA-975110|reactome:R-HSA-975144|reactome:R-HSA-983168|dip:DIP-41911N	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S3|resulting-ptm:Q9BZV1 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:EwhjYjowkZIAt4UyPcZBUtf9uak10116	rogid:x95N7Dj2KIqu5gySX59xLmfthUg9606	intact-crc:8D14163F4F731623|rigid:5w9MjuYBajhDpqrFN03GSRWcYTo	false	sufficient binding region:433-481(IPR013083)	his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q62925	uniprotkb:P22314	intact:EBI-636664	intact:EBI-709688|uniprotkb:Q96E13|uniprotkb:Q5JRR8|ensembl:ENSP00000338413|ensembl:ENSP00000366568	psi-mi:m3k1_rat(display_long)|uniprotkb:MAPK/ERK kinase kinase 1(gene name synonym)|uniprotkb:Map3k1(gene name)|psi-mi:Map3k1(display_short)|uniprotkb:Mekk(gene name synonym)|uniprotkb:Mekk1(gene name synonym)	psi-mi:uba1_human(display_long)|uniprotkb:Ubiquitin-activating enzyme E1(gene name synonym)|uniprotkb:Protein A1S9(gene name synonym)|uniprotkb:UBA1(gene name)|psi-mi:UBA1(display_short)|uniprotkb:A1S9T(gene name synonym)|uniprotkb:UBE1(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9972638|imex:IM-22822-119	author-confidence:Z-score = 9.05|author-confidence:Z-score = 10.76	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:620966|refseq:NP_446339.1|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR007527(Zinc finger, SWIM-type)|go:"GO:0000165"(MAPK cascade)|interpro:IPR016024(Armadillo-type fold)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0002011"(morphogenesis of an epithelial sheet)|go:"GO:0003382"(epithelial cell morphogenesis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004706"(JUN kinase kinase kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007254"(JNK cascade)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008432"(JUN kinase binding)|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0016020"(membrane)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0031434"(mitogen-activated protein kinase kinase binding)|go:"GO:0031941"(filamentous actin)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0042060"(wound healing)|go:"GO:0043010"(camera-type eye development)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046625"(sphingolipid binding)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050434"(positive regulation of viral transcription)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0061029"(eyelid development in camera-type eye)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|reactome:R-RNO-166058|reactome:R-RNO-2871796|reactome:R-RNO-975138|reactome:R-RNO-975871|interpro:IPR011989(Armadillo-like helical)|mint:Q62925	refseq:NP_003325.2|refseq:NP_695012.1|refseq:XP_016885269.1|refseq:XP_016885270.1|dip:DIP-33686N|ensembl:ENSG00000130985(gene)|ensembl:ENST00000335972(transcript)|ensembl:ENST00000377351(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0004839"(ubiquitin activating enzyme activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0032446"(protein modification by small protein conjugation)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000011(Ubiquitin-activating enzyme, E1)|interpro:IPR000594(UBA/THIF-type NAD/FAD binding fold)|interpro:IPR018074|interpro:IPR018075|interpro:IPR018965|interpro:IPR019572|interpro:IPR032418|interpro:IPR032420|interpro:IPR033127|interpro:IPR035985|interpro:IPR038252|interpro:IPR042063|interpro:IPR042302|interpro:IPR042449|mint:P22314|rcsb pdb:4P22|rcsb pdb:6DC6|reactome:R-HSA-8866652|reactome:R-HSA-983168	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S3|resulting-ptm:Q9BZV1 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:EwhjYjowkZIAt4UyPcZBUtf9uak10116	rogid:q+vEeA0XLST0Zz173bmEt0dNbDE9606	intact-crc:8D14163F4F731623|rigid:5w9MjuYBajhDpqrFN03GSRWcYTo	false	sufficient binding region:433-481(IPR013083)	his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q62925	uniprotkb:P61088	intact:EBI-636664	intact:EBI-1052908|uniprotkb:Q16781|uniprotkb:Q53Y81|ensembl:ENSP00000316176	psi-mi:m3k1_rat(display_long)|uniprotkb:MAPK/ERK kinase kinase 1(gene name synonym)|uniprotkb:Map3k1(gene name)|psi-mi:Map3k1(display_short)|uniprotkb:Mekk(gene name synonym)|uniprotkb:Mekk1(gene name synonym)	psi-mi:ube2n_human(display_long)|uniprotkb:Ubiquitin-protein ligase N(gene name synonym)|uniprotkb:Ubiquitin carrier protein N(gene name synonym)|uniprotkb:Ubc13(gene name synonym)|uniprotkb:Bendless-like ubiquitin-conjugating enzyme(gene name synonym)|uniprotkb:UBE2N(gene name)|psi-mi:UBE2N(display_short)|uniprotkb:BLU(gene name synonym)|uniprotkb:UbcH13(gene name synonym)|uniprotkb:E2 ubiquitin-conjugating enzyme N(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9972638|imex:IM-22822-119	author-confidence:Z-score = 9.05|author-confidence:Z-score = 10.76	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:620966|refseq:NP_446339.1|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR007527(Zinc finger, SWIM-type)|go:"GO:0000165"(MAPK cascade)|interpro:IPR016024(Armadillo-type fold)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0002011"(morphogenesis of an epithelial sheet)|go:"GO:0003382"(epithelial cell morphogenesis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004706"(JUN kinase kinase kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007254"(JNK cascade)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008432"(JUN kinase binding)|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0016020"(membrane)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0031434"(mitogen-activated protein kinase kinase binding)|go:"GO:0031941"(filamentous actin)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0042060"(wound healing)|go:"GO:0043010"(camera-type eye development)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046625"(sphingolipid binding)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050434"(positive regulation of viral transcription)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0061029"(eyelid development in camera-type eye)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|reactome:R-RNO-166058|reactome:R-RNO-2871796|reactome:R-RNO-975138|reactome:R-RNO-975871|interpro:IPR011989(Armadillo-like helical)|mint:Q62925	refseq:NP_003339.1|dip:DIP-29829N|ensembl:ENSG00000177889(gene)|ensembl:ENST00000318066(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000729"(DNA double-strand break processing)|go:"GO:0001650"(fibrillar center)|go:"GO:0003723"(RNA binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006282"(regulation of DNA repair)|go:"GO:0006301"(postreplication repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016574"(histone ubiquitination)|go:"GO:0031058"(positive regulation of histone modification)|go:"GO:0031372"(UBC13-MMS2 complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033182"(regulation of histone ubiquitination)|go:"GO:0035370"(UBC13-UEV1A complex)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0061631"(ubiquitin conjugating enzyme activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070534"(protein K63-linked ubiquitination)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|interpro:IPR023313|rcsb pdb:1J7D|rcsb pdb:2C2V|rcsb pdb:3HCT|rcsb pdb:3HCU|rcsb pdb:3VON|rcsb pdb:3W31|rcsb pdb:4DHI|rcsb pdb:4DHJ|rcsb pdb:4DHZ|rcsb pdb:4IP3|rcsb pdb:4NR3|rcsb pdb:4NRG|rcsb pdb:4NRI|rcsb pdb:4ONL|rcsb pdb:4ONM|rcsb pdb:4ONN|rcsb pdb:4ORH|rcsb pdb:4TKP|rcsb pdb:4WHV|rcsb pdb:5AIT|rcsb pdb:5AIU|rcsb pdb:5EYA|rcsb pdb:5H7S|rcsb pdb:5VNZ|rcsb pdb:5VO0|rcsb pdb:5YWR|rcsb pdb:6D6I|rcsb pdb:6JKY|rcsb pdb:6KFP|rcsb pdb:6KG6|rcsb pdb:6KL4|rcsb pdb:6LP2|rcsb pdb:6P5B|rcsb pdb:6S53|reactome:R-HSA-168927|reactome:R-HSA-202424|reactome:R-HSA-2871837|reactome:R-HSA-445989|reactome:R-HSA-450302|reactome:R-HSA-450321|reactome:R-HSA-5607764|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-5696395|reactome:R-HSA-69473|reactome:R-HSA-8866654|reactome:R-HSA-9020702|reactome:R-HSA-937039|reactome:R-HSA-937041|reactome:R-HSA-9646399|reactome:R-HSA-975110|reactome:R-HSA-975144|reactome:R-HSA-983168|rcsb pdb:6ULH|rcsb pdb:6UMP|rcsb pdb:6UMS|rcsb pdb:7BBD|rcsb pdb:7BBF|rcsb pdb:7BXG|reactome:R-HSA-1169408|reactome:R-HSA-168638	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S3|resulting-ptm:Q9BZV1 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:EwhjYjowkZIAt4UyPcZBUtf9uak10116	rogid:dqdszHlq5FLPHC6UWX6uvkC6Yz89606	intact-crc:8D14163F4F731623|rigid:5w9MjuYBajhDpqrFN03GSRWcYTo	false	sufficient binding region:433-481(IPR013083)	his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q62925	uniprotkb:Q9BZV1	intact:EBI-636664	intact:EBI-1993899|uniprotkb:D6W626|uniprotkb:Q96AH1|uniprotkb:Q96IK9|uniprotkb:Q9BZV0|ensembl:ENSP00000301281	psi-mi:m3k1_rat(display_long)|uniprotkb:MAPK/ERK kinase kinase 1(gene name synonym)|uniprotkb:Map3k1(gene name)|psi-mi:Map3k1(display_short)|uniprotkb:Mekk(gene name synonym)|uniprotkb:Mekk1(gene name synonym)	psi-mi:ubxn6_human(display_long)|uniprotkb:UBXN6(gene name)|psi-mi:UBXN6(display_short)|uniprotkb:UBXD1(gene name synonym)|uniprotkb:UBXDC2(gene name synonym)|uniprotkb:UBX domain-containing protein 1(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9972638|imex:IM-22822-119	author-confidence:Z-score = 9.05|author-confidence:Z-score = 10.76	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:620966|refseq:NP_446339.1|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR007527(Zinc finger, SWIM-type)|go:"GO:0000165"(MAPK cascade)|interpro:IPR016024(Armadillo-type fold)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0002011"(morphogenesis of an epithelial sheet)|go:"GO:0003382"(epithelial cell morphogenesis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004706"(JUN kinase kinase kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007254"(JNK cascade)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008432"(JUN kinase binding)|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0016020"(membrane)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0031434"(mitogen-activated protein kinase kinase binding)|go:"GO:0031941"(filamentous actin)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0042060"(wound healing)|go:"GO:0043010"(camera-type eye development)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046625"(sphingolipid binding)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050434"(positive regulation of viral transcription)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0061029"(eyelid development in camera-type eye)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|reactome:R-RNO-166058|reactome:R-RNO-2871796|reactome:R-RNO-975138|reactome:R-RNO-975871|interpro:IPR011989(Armadillo-like helical)|mint:Q62925	refseq:NP_001164562.1|refseq:NP_079517.1|go:"GO:0005737"(cytoplasm)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005768"(endosome)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0016236"(macroautophagy)|go:"GO:0019898"(extrinsic component of membrane)|go:"GO:0031901"(early endosome membrane)|go:"GO:0031902"(late endosome membrane)|go:"GO:0032510"(endosome to lysosome transport via multivesicular body sorting pathway)|go:"GO:0032991"(protein-containing complex)|go:"GO:0036503"(ERAD pathway)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001012(UBX)|interpro:IPR018997|interpro:IPR029071|interpro:IPR036339|interpro:IPR042774|rcsb pdb:6SAP|ensembl:ENSG00000167671(gene)|ensembl:ENST00000301281(transcript)|go:"GO:0005634"(nucleus)	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S3|resulting-ptm:Q9BZV1 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:EwhjYjowkZIAt4UyPcZBUtf9uak10116	rogid:bdhN1ftwK7aQRHUgkBTclJ/z3SQ9606	intact-crc:8D14163F4F731623|rigid:5w9MjuYBajhDpqrFN03GSRWcYTo	false	sufficient binding region:433-481(IPR013083)	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9H1I8	uniprotkb:Q62925	intact:EBI-711197|uniprotkb:Q4TT54|uniprotkb:Q8TAZ0|uniprotkb:Q9H711|ensembl:ENSP00000305502|ensembl:ENSP00000380877|uniprotkb:Q9H9D6|uniprotkb:B7Z8E0|uniprotkb:F5H6J9	intact:EBI-636664	psi-mi:ascc2_human(display_long)|uniprotkb:ASC-1 complex subunit p100(gene name synonym)|uniprotkb:Trip4 complex subunit p100(gene name synonym)|uniprotkb:ASCC2(gene name)|psi-mi:ASCC2(display_short)|uniprotkb:ASC1P100(gene name synonym)|uniprotkb:RQT3(gene name synonym)	psi-mi:m3k1_rat(display_long)|uniprotkb:MAPK/ERK kinase kinase 1(gene name synonym)|uniprotkb:Map3k1(gene name)|psi-mi:Map3k1(display_short)|uniprotkb:Mekk(gene name synonym)|uniprotkb:Mekk1(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9972664|imex:IM-22822-120	author-confidence:Z-score = 10.78	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_115580.2|ensembl:ENSG00000100325(gene)|ensembl:ENST00000307790(transcript)|ensembl:ENST00000397771(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0016607"(nuclear speck)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0099053"(activating signal cointegrator 1 complex)|interpro:IPR003892(Ubiquitin system component Cue)|interpro:IPR009060(UBA-like)|interpro:IPR041800|rcsb pdb:2DI0|rcsb pdb:6YXQ|reactome:R-HSA-112126|refseq:XP_005261832.1|refseq:NP_001229835.1|refseq:XP_016884487.1|refseq:XP_016884488.1|refseq:XP_016884489.1	rgd:620966|refseq:NP_446339.1|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR007527(Zinc finger, SWIM-type)|go:"GO:0000165"(MAPK cascade)|interpro:IPR016024(Armadillo-type fold)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0002011"(morphogenesis of an epithelial sheet)|go:"GO:0003382"(epithelial cell morphogenesis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004706"(JUN kinase kinase kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007254"(JNK cascade)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008432"(JUN kinase binding)|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0016020"(membrane)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0031434"(mitogen-activated protein kinase kinase binding)|go:"GO:0031941"(filamentous actin)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0042060"(wound healing)|go:"GO:0043010"(camera-type eye development)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046625"(sphingolipid binding)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050434"(positive regulation of viral transcription)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0061029"(eyelid development in camera-type eye)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|reactome:R-RNO-166058|reactome:R-RNO-2871796|reactome:R-RNO-975138|reactome:R-RNO-975871|interpro:IPR011989(Armadillo-like helical)|mint:Q62925	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S3|resulting-ptm:Q9H1I8 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:aml0rAAbXH3AzmuVZEmwegUA10k9606	rogid:EwhjYjowkZIAt4UyPcZBUtf9uak10116	intact-crc:5229A88B12E095CB|rigid:l0icIb9r3wL2UrokjIXiHt9oYHc	false	-	sufficient binding region:433-481(IPR013083)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9H1I8	uniprotkb:Q13404	intact:EBI-711197|uniprotkb:Q4TT54|uniprotkb:Q8TAZ0|uniprotkb:Q9H711|ensembl:ENSP00000305502|ensembl:ENSP00000380877|uniprotkb:Q9H9D6|uniprotkb:B7Z8E0|uniprotkb:F5H6J9	intact:EBI-1050671|uniprotkb:Q13403|uniprotkb:Q13532|uniprotkb:Q96H34|uniprotkb:Q9GZT0|uniprotkb:Q9GZW1|uniprotkb:Q9H4J3|uniprotkb:Q9H4J4|uniprotkb:Q9UKL1|uniprotkb:Q9UM48|uniprotkb:Q9UM49|uniprotkb:Q9UM50|uniprotkb:Q5TGE3|uniprotkb:E1P629|uniprotkb:Q5TGE0|ensembl:ENSP00000360739	psi-mi:ascc2_human(display_long)|uniprotkb:ASC-1 complex subunit p100(gene name synonym)|uniprotkb:Trip4 complex subunit p100(gene name synonym)|uniprotkb:ASCC2(gene name)|psi-mi:ASCC2(display_short)|uniprotkb:ASC1P100(gene name synonym)|uniprotkb:RQT3(gene name synonym)	psi-mi:ub2v1_human(display_long)|uniprotkb:CROC-1(gene name synonym)|uniprotkb:TRAF6-regulated IKK activator 1 beta Uev1A(gene name synonym)|uniprotkb:P/OKcl.19(orf name)|uniprotkb:UBE2V1(gene name)|psi-mi:UBE2V1(display_short)|uniprotkb:CROC1(gene name synonym)|uniprotkb:UBE2V(gene name synonym)|uniprotkb:UEV1(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9972664|imex:IM-22822-120	author-confidence:Z-score = 10.78	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_115580.2|ensembl:ENSG00000100325(gene)|ensembl:ENST00000307790(transcript)|ensembl:ENST00000397771(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0016607"(nuclear speck)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0099053"(activating signal cointegrator 1 complex)|interpro:IPR003892(Ubiquitin system component Cue)|interpro:IPR009060(UBA-like)|interpro:IPR041800|rcsb pdb:2DI0|rcsb pdb:6YXQ|reactome:R-HSA-112126|refseq:XP_005261832.1|refseq:NP_001229835.1|refseq:XP_016884487.1|refseq:XP_016884488.1|refseq:XP_016884489.1	refseq:NP_001027459.1|refseq:NP_068823.2|refseq:NP_071887.1|refseq:NP_954595.1|refseq:NP_954673.1|refseq:NP_001244322.1|refseq:NP_001244323.1|refseq:NP_001244325.1|ensembl:ENSG00000244687(gene)|ensembl:ENST00000371674(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006282"(regulation of DNA repair)|go:"GO:0006301"(postreplication repair)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0030154"(cell differentiation)|go:"GO:0031371"(ubiquitin conjugating enzyme complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035370"(UBC13-UEV1A complex)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070534"(protein K63-linked ubiquitination)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|rcsb pdb:2A4D|rcsb pdb:2C2V|rcsb pdb:2HLW|rcsb pdb:6D6I|reactome:R-HSA-168638|reactome:R-HSA-168927|reactome:R-HSA-202424|reactome:R-HSA-2871837|reactome:R-HSA-445989|reactome:R-HSA-450302|reactome:R-HSA-450321|reactome:R-HSA-5607764|reactome:R-HSA-9020702|reactome:R-HSA-937039|reactome:R-HSA-937041|reactome:R-HSA-9646399|reactome:R-HSA-975110|reactome:R-HSA-975144|reactome:R-HSA-983168|dip:DIP-41911N	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S3|resulting-ptm:Q9H1I8 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:aml0rAAbXH3AzmuVZEmwegUA10k9606	rogid:x95N7Dj2KIqu5gySX59xLmfthUg9606	intact-crc:5229A88B12E095CB|rigid:l0icIb9r3wL2UrokjIXiHt9oYHc	false	-	his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9H1I8	uniprotkb:P22314	intact:EBI-711197|uniprotkb:Q4TT54|uniprotkb:Q8TAZ0|uniprotkb:Q9H711|ensembl:ENSP00000305502|ensembl:ENSP00000380877|uniprotkb:Q9H9D6|uniprotkb:B7Z8E0|uniprotkb:F5H6J9	intact:EBI-709688|uniprotkb:Q96E13|uniprotkb:Q5JRR8|ensembl:ENSP00000338413|ensembl:ENSP00000366568	psi-mi:ascc2_human(display_long)|uniprotkb:ASC-1 complex subunit p100(gene name synonym)|uniprotkb:Trip4 complex subunit p100(gene name synonym)|uniprotkb:ASCC2(gene name)|psi-mi:ASCC2(display_short)|uniprotkb:ASC1P100(gene name synonym)|uniprotkb:RQT3(gene name synonym)	psi-mi:uba1_human(display_long)|uniprotkb:Ubiquitin-activating enzyme E1(gene name synonym)|uniprotkb:Protein A1S9(gene name synonym)|uniprotkb:UBA1(gene name)|psi-mi:UBA1(display_short)|uniprotkb:A1S9T(gene name synonym)|uniprotkb:UBE1(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9972664|imex:IM-22822-120	author-confidence:Z-score = 10.78	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_115580.2|ensembl:ENSG00000100325(gene)|ensembl:ENST00000307790(transcript)|ensembl:ENST00000397771(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0016607"(nuclear speck)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0099053"(activating signal cointegrator 1 complex)|interpro:IPR003892(Ubiquitin system component Cue)|interpro:IPR009060(UBA-like)|interpro:IPR041800|rcsb pdb:2DI0|rcsb pdb:6YXQ|reactome:R-HSA-112126|refseq:XP_005261832.1|refseq:NP_001229835.1|refseq:XP_016884487.1|refseq:XP_016884488.1|refseq:XP_016884489.1	refseq:NP_003325.2|refseq:NP_695012.1|refseq:XP_016885269.1|refseq:XP_016885270.1|dip:DIP-33686N|ensembl:ENSG00000130985(gene)|ensembl:ENST00000335972(transcript)|ensembl:ENST00000377351(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0004839"(ubiquitin activating enzyme activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0032446"(protein modification by small protein conjugation)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000011(Ubiquitin-activating enzyme, E1)|interpro:IPR000594(UBA/THIF-type NAD/FAD binding fold)|interpro:IPR018074|interpro:IPR018075|interpro:IPR018965|interpro:IPR019572|interpro:IPR032418|interpro:IPR032420|interpro:IPR033127|interpro:IPR035985|interpro:IPR038252|interpro:IPR042063|interpro:IPR042302|interpro:IPR042449|mint:P22314|rcsb pdb:4P22|rcsb pdb:6DC6|reactome:R-HSA-8866652|reactome:R-HSA-983168	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S3|resulting-ptm:Q9H1I8 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:aml0rAAbXH3AzmuVZEmwegUA10k9606	rogid:q+vEeA0XLST0Zz173bmEt0dNbDE9606	intact-crc:5229A88B12E095CB|rigid:l0icIb9r3wL2UrokjIXiHt9oYHc	false	-	his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9H1I8	uniprotkb:P61088	intact:EBI-711197|uniprotkb:Q4TT54|uniprotkb:Q8TAZ0|uniprotkb:Q9H711|ensembl:ENSP00000305502|ensembl:ENSP00000380877|uniprotkb:Q9H9D6|uniprotkb:B7Z8E0|uniprotkb:F5H6J9	intact:EBI-1052908|uniprotkb:Q16781|uniprotkb:Q53Y81|ensembl:ENSP00000316176	psi-mi:ascc2_human(display_long)|uniprotkb:ASC-1 complex subunit p100(gene name synonym)|uniprotkb:Trip4 complex subunit p100(gene name synonym)|uniprotkb:ASCC2(gene name)|psi-mi:ASCC2(display_short)|uniprotkb:ASC1P100(gene name synonym)|uniprotkb:RQT3(gene name synonym)	psi-mi:ube2n_human(display_long)|uniprotkb:Ubiquitin-protein ligase N(gene name synonym)|uniprotkb:Ubiquitin carrier protein N(gene name synonym)|uniprotkb:Ubc13(gene name synonym)|uniprotkb:Bendless-like ubiquitin-conjugating enzyme(gene name synonym)|uniprotkb:UBE2N(gene name)|psi-mi:UBE2N(display_short)|uniprotkb:BLU(gene name synonym)|uniprotkb:UbcH13(gene name synonym)|uniprotkb:E2 ubiquitin-conjugating enzyme N(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9972664|imex:IM-22822-120	author-confidence:Z-score = 10.78	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_115580.2|ensembl:ENSG00000100325(gene)|ensembl:ENST00000307790(transcript)|ensembl:ENST00000397771(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0016607"(nuclear speck)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0099053"(activating signal cointegrator 1 complex)|interpro:IPR003892(Ubiquitin system component Cue)|interpro:IPR009060(UBA-like)|interpro:IPR041800|rcsb pdb:2DI0|rcsb pdb:6YXQ|reactome:R-HSA-112126|refseq:XP_005261832.1|refseq:NP_001229835.1|refseq:XP_016884487.1|refseq:XP_016884488.1|refseq:XP_016884489.1	refseq:NP_003339.1|dip:DIP-29829N|ensembl:ENSG00000177889(gene)|ensembl:ENST00000318066(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000729"(DNA double-strand break processing)|go:"GO:0001650"(fibrillar center)|go:"GO:0003723"(RNA binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006282"(regulation of DNA repair)|go:"GO:0006301"(postreplication repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016574"(histone ubiquitination)|go:"GO:0031058"(positive regulation of histone modification)|go:"GO:0031372"(UBC13-MMS2 complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033182"(regulation of histone ubiquitination)|go:"GO:0035370"(UBC13-UEV1A complex)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0061631"(ubiquitin conjugating enzyme activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070534"(protein K63-linked ubiquitination)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|interpro:IPR023313|rcsb pdb:1J7D|rcsb pdb:2C2V|rcsb pdb:3HCT|rcsb pdb:3HCU|rcsb pdb:3VON|rcsb pdb:3W31|rcsb pdb:4DHI|rcsb pdb:4DHJ|rcsb pdb:4DHZ|rcsb pdb:4IP3|rcsb pdb:4NR3|rcsb pdb:4NRG|rcsb pdb:4NRI|rcsb pdb:4ONL|rcsb pdb:4ONM|rcsb pdb:4ONN|rcsb pdb:4ORH|rcsb pdb:4TKP|rcsb pdb:4WHV|rcsb pdb:5AIT|rcsb pdb:5AIU|rcsb pdb:5EYA|rcsb pdb:5H7S|rcsb pdb:5VNZ|rcsb pdb:5VO0|rcsb pdb:5YWR|rcsb pdb:6D6I|rcsb pdb:6JKY|rcsb pdb:6KFP|rcsb pdb:6KG6|rcsb pdb:6KL4|rcsb pdb:6LP2|rcsb pdb:6P5B|rcsb pdb:6S53|reactome:R-HSA-168927|reactome:R-HSA-202424|reactome:R-HSA-2871837|reactome:R-HSA-445989|reactome:R-HSA-450302|reactome:R-HSA-450321|reactome:R-HSA-5607764|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-5696395|reactome:R-HSA-69473|reactome:R-HSA-8866654|reactome:R-HSA-9020702|reactome:R-HSA-937039|reactome:R-HSA-937041|reactome:R-HSA-9646399|reactome:R-HSA-975110|reactome:R-HSA-975144|reactome:R-HSA-983168|rcsb pdb:6ULH|rcsb pdb:6UMP|rcsb pdb:6UMS|rcsb pdb:7BBD|rcsb pdb:7BBF|rcsb pdb:7BXG|reactome:R-HSA-1169408|reactome:R-HSA-168638	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S3|resulting-ptm:Q9H1I8 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:aml0rAAbXH3AzmuVZEmwegUA10k9606	rogid:dqdszHlq5FLPHC6UWX6uvkC6Yz89606	intact-crc:5229A88B12E095CB|rigid:l0icIb9r3wL2UrokjIXiHt9oYHc	false	-	his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q62925	uniprotkb:Q9H5N1	intact:EBI-636664	intact:EBI-3940735|ensembl:ENSP00000350934	psi-mi:m3k1_rat(display_long)|uniprotkb:MAPK/ERK kinase kinase 1(gene name synonym)|uniprotkb:Map3k1(gene name)|psi-mi:Map3k1(display_short)|uniprotkb:Mekk(gene name synonym)|uniprotkb:Mekk1(gene name synonym)	psi-mi:rabe2_human(display_long)|uniprotkb:RABEP2(gene name)|psi-mi:RABEP2(display_short)|uniprotkb:RABPT5B(gene name synonym)|uniprotkb:Rabaptin-5beta(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9972689|imex:IM-22822-121	author-confidence:Z-score = 3.21	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:620966|refseq:NP_446339.1|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR007527(Zinc finger, SWIM-type)|go:"GO:0000165"(MAPK cascade)|interpro:IPR016024(Armadillo-type fold)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0002011"(morphogenesis of an epithelial sheet)|go:"GO:0003382"(epithelial cell morphogenesis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004706"(JUN kinase kinase kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007254"(JNK cascade)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008432"(JUN kinase binding)|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0016020"(membrane)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0031434"(mitogen-activated protein kinase kinase binding)|go:"GO:0031941"(filamentous actin)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0042060"(wound healing)|go:"GO:0043010"(camera-type eye development)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046625"(sphingolipid binding)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050434"(positive regulation of viral transcription)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0061029"(eyelid development in camera-type eye)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|reactome:R-RNO-166058|reactome:R-RNO-2871796|reactome:R-RNO-975138|reactome:R-RNO-975871|interpro:IPR011989(Armadillo-like helical)|mint:Q62925	ensembl:ENSG00000177548(gene)|ensembl:ENST00000358201(transcript)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005769"(early endosome)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006897"(endocytosis)|go:"GO:0008083"(growth factor activity)|go:"GO:0015031"(protein transport)|go:"GO:0030030"(cell projection organization)|go:"GO:0036064"(ciliary basal body)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:1902017"(regulation of cilium assembly)|interpro:IPR003914(Rabaptin)|interpro:IPR015390(Rabaptin, GTPase-Rab5 binding)|interpro:IPR018514|interpro:IPR029882|refseq:NP_079092.2	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S3|resulting-ptm:Q9H5N1 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:EwhjYjowkZIAt4UyPcZBUtf9uak10116	rogid:pcTL9W2UHdUPv+Nl+bHFRXEoK309606	intact-crc:826B5049E7BF529A|rigid:FQmbwharvxGHcDSprufXvZ6hofM	false	sufficient binding region:433-481(IPR013083)	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q62925	uniprotkb:Q13404	intact:EBI-636664	intact:EBI-1050671|uniprotkb:Q13403|uniprotkb:Q13532|uniprotkb:Q96H34|uniprotkb:Q9GZT0|uniprotkb:Q9GZW1|uniprotkb:Q9H4J3|uniprotkb:Q9H4J4|uniprotkb:Q9UKL1|uniprotkb:Q9UM48|uniprotkb:Q9UM49|uniprotkb:Q9UM50|uniprotkb:Q5TGE3|uniprotkb:E1P629|uniprotkb:Q5TGE0|ensembl:ENSP00000360739	psi-mi:m3k1_rat(display_long)|uniprotkb:MAPK/ERK kinase kinase 1(gene name synonym)|uniprotkb:Map3k1(gene name)|psi-mi:Map3k1(display_short)|uniprotkb:Mekk(gene name synonym)|uniprotkb:Mekk1(gene name synonym)	psi-mi:ub2v1_human(display_long)|uniprotkb:CROC-1(gene name synonym)|uniprotkb:TRAF6-regulated IKK activator 1 beta Uev1A(gene name synonym)|uniprotkb:P/OKcl.19(orf name)|uniprotkb:UBE2V1(gene name)|psi-mi:UBE2V1(display_short)|uniprotkb:CROC1(gene name synonym)|uniprotkb:UBE2V(gene name synonym)|uniprotkb:UEV1(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9972689|imex:IM-22822-121	author-confidence:Z-score = 3.21	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:620966|refseq:NP_446339.1|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR007527(Zinc finger, SWIM-type)|go:"GO:0000165"(MAPK cascade)|interpro:IPR016024(Armadillo-type fold)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0002011"(morphogenesis of an epithelial sheet)|go:"GO:0003382"(epithelial cell morphogenesis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004706"(JUN kinase kinase kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007254"(JNK cascade)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008432"(JUN kinase binding)|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0016020"(membrane)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0031434"(mitogen-activated protein kinase kinase binding)|go:"GO:0031941"(filamentous actin)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0042060"(wound healing)|go:"GO:0043010"(camera-type eye development)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046625"(sphingolipid binding)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050434"(positive regulation of viral transcription)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0061029"(eyelid development in camera-type eye)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|reactome:R-RNO-166058|reactome:R-RNO-2871796|reactome:R-RNO-975138|reactome:R-RNO-975871|interpro:IPR011989(Armadillo-like helical)|mint:Q62925	refseq:NP_001027459.1|refseq:NP_068823.2|refseq:NP_071887.1|refseq:NP_954595.1|refseq:NP_954673.1|refseq:NP_001244322.1|refseq:NP_001244323.1|refseq:NP_001244325.1|ensembl:ENSG00000244687(gene)|ensembl:ENST00000371674(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006282"(regulation of DNA repair)|go:"GO:0006301"(postreplication repair)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0030154"(cell differentiation)|go:"GO:0031371"(ubiquitin conjugating enzyme complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035370"(UBC13-UEV1A complex)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070534"(protein K63-linked ubiquitination)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|rcsb pdb:2A4D|rcsb pdb:2C2V|rcsb pdb:2HLW|rcsb pdb:6D6I|reactome:R-HSA-168638|reactome:R-HSA-168927|reactome:R-HSA-202424|reactome:R-HSA-2871837|reactome:R-HSA-445989|reactome:R-HSA-450302|reactome:R-HSA-450321|reactome:R-HSA-5607764|reactome:R-HSA-9020702|reactome:R-HSA-937039|reactome:R-HSA-937041|reactome:R-HSA-9646399|reactome:R-HSA-975110|reactome:R-HSA-975144|reactome:R-HSA-983168|dip:DIP-41911N	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S3|resulting-ptm:Q9H5N1 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:EwhjYjowkZIAt4UyPcZBUtf9uak10116	rogid:x95N7Dj2KIqu5gySX59xLmfthUg9606	intact-crc:826B5049E7BF529A|rigid:FQmbwharvxGHcDSprufXvZ6hofM	false	sufficient binding region:433-481(IPR013083)	his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q62925	uniprotkb:P22314	intact:EBI-636664	intact:EBI-709688|uniprotkb:Q96E13|uniprotkb:Q5JRR8|ensembl:ENSP00000338413|ensembl:ENSP00000366568	psi-mi:m3k1_rat(display_long)|uniprotkb:MAPK/ERK kinase kinase 1(gene name synonym)|uniprotkb:Map3k1(gene name)|psi-mi:Map3k1(display_short)|uniprotkb:Mekk(gene name synonym)|uniprotkb:Mekk1(gene name synonym)	psi-mi:uba1_human(display_long)|uniprotkb:Ubiquitin-activating enzyme E1(gene name synonym)|uniprotkb:Protein A1S9(gene name synonym)|uniprotkb:UBA1(gene name)|psi-mi:UBA1(display_short)|uniprotkb:A1S9T(gene name synonym)|uniprotkb:UBE1(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9972689|imex:IM-22822-121	author-confidence:Z-score = 3.21	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:620966|refseq:NP_446339.1|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR007527(Zinc finger, SWIM-type)|go:"GO:0000165"(MAPK cascade)|interpro:IPR016024(Armadillo-type fold)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0002011"(morphogenesis of an epithelial sheet)|go:"GO:0003382"(epithelial cell morphogenesis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004706"(JUN kinase kinase kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007254"(JNK cascade)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008432"(JUN kinase binding)|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0016020"(membrane)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0031434"(mitogen-activated protein kinase kinase binding)|go:"GO:0031941"(filamentous actin)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0042060"(wound healing)|go:"GO:0043010"(camera-type eye development)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046625"(sphingolipid binding)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050434"(positive regulation of viral transcription)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0061029"(eyelid development in camera-type eye)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|reactome:R-RNO-166058|reactome:R-RNO-2871796|reactome:R-RNO-975138|reactome:R-RNO-975871|interpro:IPR011989(Armadillo-like helical)|mint:Q62925	refseq:NP_003325.2|refseq:NP_695012.1|refseq:XP_016885269.1|refseq:XP_016885270.1|dip:DIP-33686N|ensembl:ENSG00000130985(gene)|ensembl:ENST00000335972(transcript)|ensembl:ENST00000377351(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0004839"(ubiquitin activating enzyme activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0032446"(protein modification by small protein conjugation)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000011(Ubiquitin-activating enzyme, E1)|interpro:IPR000594(UBA/THIF-type NAD/FAD binding fold)|interpro:IPR018074|interpro:IPR018075|interpro:IPR018965|interpro:IPR019572|interpro:IPR032418|interpro:IPR032420|interpro:IPR033127|interpro:IPR035985|interpro:IPR038252|interpro:IPR042063|interpro:IPR042302|interpro:IPR042449|mint:P22314|rcsb pdb:4P22|rcsb pdb:6DC6|reactome:R-HSA-8866652|reactome:R-HSA-983168	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S3|resulting-ptm:Q9H5N1 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:EwhjYjowkZIAt4UyPcZBUtf9uak10116	rogid:q+vEeA0XLST0Zz173bmEt0dNbDE9606	intact-crc:826B5049E7BF529A|rigid:FQmbwharvxGHcDSprufXvZ6hofM	false	sufficient binding region:433-481(IPR013083)	his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q62925	uniprotkb:P61088	intact:EBI-636664	intact:EBI-1052908|uniprotkb:Q16781|uniprotkb:Q53Y81|ensembl:ENSP00000316176	psi-mi:m3k1_rat(display_long)|uniprotkb:MAPK/ERK kinase kinase 1(gene name synonym)|uniprotkb:Map3k1(gene name)|psi-mi:Map3k1(display_short)|uniprotkb:Mekk(gene name synonym)|uniprotkb:Mekk1(gene name synonym)	psi-mi:ube2n_human(display_long)|uniprotkb:Ubiquitin-protein ligase N(gene name synonym)|uniprotkb:Ubiquitin carrier protein N(gene name synonym)|uniprotkb:Ubc13(gene name synonym)|uniprotkb:Bendless-like ubiquitin-conjugating enzyme(gene name synonym)|uniprotkb:UBE2N(gene name)|psi-mi:UBE2N(display_short)|uniprotkb:BLU(gene name synonym)|uniprotkb:UbcH13(gene name synonym)|uniprotkb:E2 ubiquitin-conjugating enzyme N(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9972689|imex:IM-22822-121	author-confidence:Z-score = 3.21	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:620966|refseq:NP_446339.1|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR007527(Zinc finger, SWIM-type)|go:"GO:0000165"(MAPK cascade)|interpro:IPR016024(Armadillo-type fold)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0002011"(morphogenesis of an epithelial sheet)|go:"GO:0003382"(epithelial cell morphogenesis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004706"(JUN kinase kinase kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007254"(JNK cascade)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008432"(JUN kinase binding)|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0016020"(membrane)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0031434"(mitogen-activated protein kinase kinase binding)|go:"GO:0031941"(filamentous actin)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0042060"(wound healing)|go:"GO:0043010"(camera-type eye development)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046625"(sphingolipid binding)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050434"(positive regulation of viral transcription)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0061029"(eyelid development in camera-type eye)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|reactome:R-RNO-166058|reactome:R-RNO-2871796|reactome:R-RNO-975138|reactome:R-RNO-975871|interpro:IPR011989(Armadillo-like helical)|mint:Q62925	refseq:NP_003339.1|dip:DIP-29829N|ensembl:ENSG00000177889(gene)|ensembl:ENST00000318066(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000729"(DNA double-strand break processing)|go:"GO:0001650"(fibrillar center)|go:"GO:0003723"(RNA binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006282"(regulation of DNA repair)|go:"GO:0006301"(postreplication repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016574"(histone ubiquitination)|go:"GO:0031058"(positive regulation of histone modification)|go:"GO:0031372"(UBC13-MMS2 complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033182"(regulation of histone ubiquitination)|go:"GO:0035370"(UBC13-UEV1A complex)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0061631"(ubiquitin conjugating enzyme activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070534"(protein K63-linked ubiquitination)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|interpro:IPR023313|rcsb pdb:1J7D|rcsb pdb:2C2V|rcsb pdb:3HCT|rcsb pdb:3HCU|rcsb pdb:3VON|rcsb pdb:3W31|rcsb pdb:4DHI|rcsb pdb:4DHJ|rcsb pdb:4DHZ|rcsb pdb:4IP3|rcsb pdb:4NR3|rcsb pdb:4NRG|rcsb pdb:4NRI|rcsb pdb:4ONL|rcsb pdb:4ONM|rcsb pdb:4ONN|rcsb pdb:4ORH|rcsb pdb:4TKP|rcsb pdb:4WHV|rcsb pdb:5AIT|rcsb pdb:5AIU|rcsb pdb:5EYA|rcsb pdb:5H7S|rcsb pdb:5VNZ|rcsb pdb:5VO0|rcsb pdb:5YWR|rcsb pdb:6D6I|rcsb pdb:6JKY|rcsb pdb:6KFP|rcsb pdb:6KG6|rcsb pdb:6KL4|rcsb pdb:6LP2|rcsb pdb:6P5B|rcsb pdb:6S53|reactome:R-HSA-168927|reactome:R-HSA-202424|reactome:R-HSA-2871837|reactome:R-HSA-445989|reactome:R-HSA-450302|reactome:R-HSA-450321|reactome:R-HSA-5607764|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-5696395|reactome:R-HSA-69473|reactome:R-HSA-8866654|reactome:R-HSA-9020702|reactome:R-HSA-937039|reactome:R-HSA-937041|reactome:R-HSA-9646399|reactome:R-HSA-975110|reactome:R-HSA-975144|reactome:R-HSA-983168|rcsb pdb:6ULH|rcsb pdb:6UMP|rcsb pdb:6UMS|rcsb pdb:7BBD|rcsb pdb:7BBF|rcsb pdb:7BXG|reactome:R-HSA-1169408|reactome:R-HSA-168638	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S3|resulting-ptm:Q9H5N1 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:EwhjYjowkZIAt4UyPcZBUtf9uak10116	rogid:dqdszHlq5FLPHC6UWX6uvkC6Yz89606	intact-crc:826B5049E7BF529A|rigid:FQmbwharvxGHcDSprufXvZ6hofM	false	sufficient binding region:433-481(IPR013083)	his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q62925	uniprotkb:Q9H8M7	intact:EBI-636664	intact:EBI-724928|uniprotkb:Q5SZ68|uniprotkb:Q5SZ69|uniprotkb:Q5SZ70|uniprotkb:Q6IA40|uniprotkb:Q6P7P0|uniprotkb:Q7Z2S1|uniprotkb:Q8WUF1|uniprotkb:Q9H3I4|ensembl:ENSP00000277632	psi-mi:m3k1_rat(display_long)|uniprotkb:MAPK/ERK kinase kinase 1(gene name synonym)|uniprotkb:Map3k1(gene name)|psi-mi:Map3k1(display_short)|uniprotkb:Mekk(gene name synonym)|uniprotkb:Mekk1(gene name synonym)	psi-mi:miny3_human(display_long)|uniprotkb:MSTP126(orf name)|uniprotkb:My042(orf name)|uniprotkb:MINDY3(gene name)|psi-mi:MINDY3(display_short)|uniprotkb:C10orf97(gene name synonym)|uniprotkb:CARP(gene name synonym)|uniprotkb:DERP5(gene name synonym)|uniprotkb:Dermal papilla-derived protein 5(gene name synonym)|uniprotkb:Deubiquitinating enzyme MINDY-3(gene name synonym)|uniprotkb:FAM188A(gene name synonym)|uniprotkb:Protein CARP(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9972739|imex:IM-22822-123	author-confidence:Z-score = 9.83	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:620966|refseq:NP_446339.1|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR007527(Zinc finger, SWIM-type)|go:"GO:0000165"(MAPK cascade)|interpro:IPR016024(Armadillo-type fold)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0002011"(morphogenesis of an epithelial sheet)|go:"GO:0003382"(epithelial cell morphogenesis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004706"(JUN kinase kinase kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007254"(JNK cascade)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008432"(JUN kinase binding)|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0016020"(membrane)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0031434"(mitogen-activated protein kinase kinase binding)|go:"GO:0031941"(filamentous actin)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0042060"(wound healing)|go:"GO:0043010"(camera-type eye development)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046625"(sphingolipid binding)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050434"(positive regulation of viral transcription)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0061029"(eyelid development in camera-type eye)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|reactome:R-RNO-166058|reactome:R-RNO-2871796|reactome:R-RNO-975138|reactome:R-RNO-975871|interpro:IPR011989(Armadillo-like helical)|mint:Q62925	refseq:NP_079224.1|refseq:NP_001305259.1|ensembl:ENSG00000148481(gene)|ensembl:ENST00000277632(transcript)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006915"(apoptotic process)|go:"GO:0031965"(nuclear membrane)|go:"GO:1990380"(Lys48-specific deubiquitinase activity)|interpro:IPR011992(EF-Hand type)|interpro:IPR025257|interpro:IPR039785|refseq:XP_005252657.1|refseq:XP_005252659.1|refseq:XP_011517996.1|refseq:XP_016872162.1	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S3|resulting-ptm:Q9H8M7 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:EwhjYjowkZIAt4UyPcZBUtf9uak10116	rogid:g6aEz4py3G+v3v35VsWTf4dXq7U9606	intact-crc:671581021A7CC970|rigid:H2xYc1vu9EJ31aPek4gwIR5jMi0	false	sufficient binding region:433-481(IPR013083)	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q62925	uniprotkb:Q13404	intact:EBI-636664	intact:EBI-1050671|uniprotkb:Q13403|uniprotkb:Q13532|uniprotkb:Q96H34|uniprotkb:Q9GZT0|uniprotkb:Q9GZW1|uniprotkb:Q9H4J3|uniprotkb:Q9H4J4|uniprotkb:Q9UKL1|uniprotkb:Q9UM48|uniprotkb:Q9UM49|uniprotkb:Q9UM50|uniprotkb:Q5TGE3|uniprotkb:E1P629|uniprotkb:Q5TGE0|ensembl:ENSP00000360739	psi-mi:m3k1_rat(display_long)|uniprotkb:MAPK/ERK kinase kinase 1(gene name synonym)|uniprotkb:Map3k1(gene name)|psi-mi:Map3k1(display_short)|uniprotkb:Mekk(gene name synonym)|uniprotkb:Mekk1(gene name synonym)	psi-mi:ub2v1_human(display_long)|uniprotkb:CROC-1(gene name synonym)|uniprotkb:TRAF6-regulated IKK activator 1 beta Uev1A(gene name synonym)|uniprotkb:P/OKcl.19(orf name)|uniprotkb:UBE2V1(gene name)|psi-mi:UBE2V1(display_short)|uniprotkb:CROC1(gene name synonym)|uniprotkb:UBE2V(gene name synonym)|uniprotkb:UEV1(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9972739|imex:IM-22822-123	author-confidence:Z-score = 9.83	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:620966|refseq:NP_446339.1|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR007527(Zinc finger, SWIM-type)|go:"GO:0000165"(MAPK cascade)|interpro:IPR016024(Armadillo-type fold)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0002011"(morphogenesis of an epithelial sheet)|go:"GO:0003382"(epithelial cell morphogenesis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004706"(JUN kinase kinase kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007254"(JNK cascade)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008432"(JUN kinase binding)|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0016020"(membrane)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0031434"(mitogen-activated protein kinase kinase binding)|go:"GO:0031941"(filamentous actin)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0042060"(wound healing)|go:"GO:0043010"(camera-type eye development)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046625"(sphingolipid binding)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050434"(positive regulation of viral transcription)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0061029"(eyelid development in camera-type eye)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|reactome:R-RNO-166058|reactome:R-RNO-2871796|reactome:R-RNO-975138|reactome:R-RNO-975871|interpro:IPR011989(Armadillo-like helical)|mint:Q62925	refseq:NP_001027459.1|refseq:NP_068823.2|refseq:NP_071887.1|refseq:NP_954595.1|refseq:NP_954673.1|refseq:NP_001244322.1|refseq:NP_001244323.1|refseq:NP_001244325.1|ensembl:ENSG00000244687(gene)|ensembl:ENST00000371674(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006282"(regulation of DNA repair)|go:"GO:0006301"(postreplication repair)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0030154"(cell differentiation)|go:"GO:0031371"(ubiquitin conjugating enzyme complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035370"(UBC13-UEV1A complex)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070534"(protein K63-linked ubiquitination)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|rcsb pdb:2A4D|rcsb pdb:2C2V|rcsb pdb:2HLW|rcsb pdb:6D6I|reactome:R-HSA-168638|reactome:R-HSA-168927|reactome:R-HSA-202424|reactome:R-HSA-2871837|reactome:R-HSA-445989|reactome:R-HSA-450302|reactome:R-HSA-450321|reactome:R-HSA-5607764|reactome:R-HSA-9020702|reactome:R-HSA-937039|reactome:R-HSA-937041|reactome:R-HSA-9646399|reactome:R-HSA-975110|reactome:R-HSA-975144|reactome:R-HSA-983168|dip:DIP-41911N	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S3|resulting-ptm:Q9H8M7 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:EwhjYjowkZIAt4UyPcZBUtf9uak10116	rogid:x95N7Dj2KIqu5gySX59xLmfthUg9606	intact-crc:671581021A7CC970|rigid:H2xYc1vu9EJ31aPek4gwIR5jMi0	false	sufficient binding region:433-481(IPR013083)	his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q62925	uniprotkb:P22314	intact:EBI-636664	intact:EBI-709688|uniprotkb:Q96E13|uniprotkb:Q5JRR8|ensembl:ENSP00000338413|ensembl:ENSP00000366568	psi-mi:m3k1_rat(display_long)|uniprotkb:MAPK/ERK kinase kinase 1(gene name synonym)|uniprotkb:Map3k1(gene name)|psi-mi:Map3k1(display_short)|uniprotkb:Mekk(gene name synonym)|uniprotkb:Mekk1(gene name synonym)	psi-mi:uba1_human(display_long)|uniprotkb:Ubiquitin-activating enzyme E1(gene name synonym)|uniprotkb:Protein A1S9(gene name synonym)|uniprotkb:UBA1(gene name)|psi-mi:UBA1(display_short)|uniprotkb:A1S9T(gene name synonym)|uniprotkb:UBE1(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9972739|imex:IM-22822-123	author-confidence:Z-score = 9.83	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:620966|refseq:NP_446339.1|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR007527(Zinc finger, SWIM-type)|go:"GO:0000165"(MAPK cascade)|interpro:IPR016024(Armadillo-type fold)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0002011"(morphogenesis of an epithelial sheet)|go:"GO:0003382"(epithelial cell morphogenesis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004706"(JUN kinase kinase kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007254"(JNK cascade)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008432"(JUN kinase binding)|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0016020"(membrane)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0031434"(mitogen-activated protein kinase kinase binding)|go:"GO:0031941"(filamentous actin)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0042060"(wound healing)|go:"GO:0043010"(camera-type eye development)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046625"(sphingolipid binding)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050434"(positive regulation of viral transcription)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0061029"(eyelid development in camera-type eye)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|reactome:R-RNO-166058|reactome:R-RNO-2871796|reactome:R-RNO-975138|reactome:R-RNO-975871|interpro:IPR011989(Armadillo-like helical)|mint:Q62925	refseq:NP_003325.2|refseq:NP_695012.1|refseq:XP_016885269.1|refseq:XP_016885270.1|dip:DIP-33686N|ensembl:ENSG00000130985(gene)|ensembl:ENST00000335972(transcript)|ensembl:ENST00000377351(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0004839"(ubiquitin activating enzyme activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0032446"(protein modification by small protein conjugation)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000011(Ubiquitin-activating enzyme, E1)|interpro:IPR000594(UBA/THIF-type NAD/FAD binding fold)|interpro:IPR018074|interpro:IPR018075|interpro:IPR018965|interpro:IPR019572|interpro:IPR032418|interpro:IPR032420|interpro:IPR033127|interpro:IPR035985|interpro:IPR038252|interpro:IPR042063|interpro:IPR042302|interpro:IPR042449|mint:P22314|rcsb pdb:4P22|rcsb pdb:6DC6|reactome:R-HSA-8866652|reactome:R-HSA-983168	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S3|resulting-ptm:Q9H8M7 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:EwhjYjowkZIAt4UyPcZBUtf9uak10116	rogid:q+vEeA0XLST0Zz173bmEt0dNbDE9606	intact-crc:671581021A7CC970|rigid:H2xYc1vu9EJ31aPek4gwIR5jMi0	false	sufficient binding region:433-481(IPR013083)	his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q62925	uniprotkb:P61088	intact:EBI-636664	intact:EBI-1052908|uniprotkb:Q16781|uniprotkb:Q53Y81|ensembl:ENSP00000316176	psi-mi:m3k1_rat(display_long)|uniprotkb:MAPK/ERK kinase kinase 1(gene name synonym)|uniprotkb:Map3k1(gene name)|psi-mi:Map3k1(display_short)|uniprotkb:Mekk(gene name synonym)|uniprotkb:Mekk1(gene name synonym)	psi-mi:ube2n_human(display_long)|uniprotkb:Ubiquitin-protein ligase N(gene name synonym)|uniprotkb:Ubiquitin carrier protein N(gene name synonym)|uniprotkb:Ubc13(gene name synonym)|uniprotkb:Bendless-like ubiquitin-conjugating enzyme(gene name synonym)|uniprotkb:UBE2N(gene name)|psi-mi:UBE2N(display_short)|uniprotkb:BLU(gene name synonym)|uniprotkb:UbcH13(gene name synonym)|uniprotkb:E2 ubiquitin-conjugating enzyme N(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9972739|imex:IM-22822-123	author-confidence:Z-score = 9.83	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:620966|refseq:NP_446339.1|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR007527(Zinc finger, SWIM-type)|go:"GO:0000165"(MAPK cascade)|interpro:IPR016024(Armadillo-type fold)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0002011"(morphogenesis of an epithelial sheet)|go:"GO:0003382"(epithelial cell morphogenesis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004706"(JUN kinase kinase kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007254"(JNK cascade)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008432"(JUN kinase binding)|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0016020"(membrane)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0031434"(mitogen-activated protein kinase kinase binding)|go:"GO:0031941"(filamentous actin)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0042060"(wound healing)|go:"GO:0043010"(camera-type eye development)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046625"(sphingolipid binding)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050434"(positive regulation of viral transcription)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0061029"(eyelid development in camera-type eye)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|reactome:R-RNO-166058|reactome:R-RNO-2871796|reactome:R-RNO-975138|reactome:R-RNO-975871|interpro:IPR011989(Armadillo-like helical)|mint:Q62925	refseq:NP_003339.1|dip:DIP-29829N|ensembl:ENSG00000177889(gene)|ensembl:ENST00000318066(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000729"(DNA double-strand break processing)|go:"GO:0001650"(fibrillar center)|go:"GO:0003723"(RNA binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006282"(regulation of DNA repair)|go:"GO:0006301"(postreplication repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016574"(histone ubiquitination)|go:"GO:0031058"(positive regulation of histone modification)|go:"GO:0031372"(UBC13-MMS2 complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033182"(regulation of histone ubiquitination)|go:"GO:0035370"(UBC13-UEV1A complex)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0061631"(ubiquitin conjugating enzyme activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070534"(protein K63-linked ubiquitination)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|interpro:IPR023313|rcsb pdb:1J7D|rcsb pdb:2C2V|rcsb pdb:3HCT|rcsb pdb:3HCU|rcsb pdb:3VON|rcsb pdb:3W31|rcsb pdb:4DHI|rcsb pdb:4DHJ|rcsb pdb:4DHZ|rcsb pdb:4IP3|rcsb pdb:4NR3|rcsb pdb:4NRG|rcsb pdb:4NRI|rcsb pdb:4ONL|rcsb pdb:4ONM|rcsb pdb:4ONN|rcsb pdb:4ORH|rcsb pdb:4TKP|rcsb pdb:4WHV|rcsb pdb:5AIT|rcsb pdb:5AIU|rcsb pdb:5EYA|rcsb pdb:5H7S|rcsb pdb:5VNZ|rcsb pdb:5VO0|rcsb pdb:5YWR|rcsb pdb:6D6I|rcsb pdb:6JKY|rcsb pdb:6KFP|rcsb pdb:6KG6|rcsb pdb:6KL4|rcsb pdb:6LP2|rcsb pdb:6P5B|rcsb pdb:6S53|reactome:R-HSA-168927|reactome:R-HSA-202424|reactome:R-HSA-2871837|reactome:R-HSA-445989|reactome:R-HSA-450302|reactome:R-HSA-450321|reactome:R-HSA-5607764|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-5696395|reactome:R-HSA-69473|reactome:R-HSA-8866654|reactome:R-HSA-9020702|reactome:R-HSA-937039|reactome:R-HSA-937041|reactome:R-HSA-9646399|reactome:R-HSA-975110|reactome:R-HSA-975144|reactome:R-HSA-983168|rcsb pdb:6ULH|rcsb pdb:6UMP|rcsb pdb:6UMS|rcsb pdb:7BBD|rcsb pdb:7BBF|rcsb pdb:7BXG|reactome:R-HSA-1169408|reactome:R-HSA-168638	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S3|resulting-ptm:Q9H8M7 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:EwhjYjowkZIAt4UyPcZBUtf9uak10116	rogid:dqdszHlq5FLPHC6UWX6uvkC6Yz89606	intact-crc:671581021A7CC970|rigid:H2xYc1vu9EJ31aPek4gwIR5jMi0	false	sufficient binding region:433-481(IPR013083)	his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9H6K1	uniprotkb:Q62925	intact:EBI-3939494|uniprotkb:B2R8K7|uniprotkb:Q9BUR9|uniprotkb:Q5VV77|uniprotkb:Q96MG5|ensembl:ENSP00000363135	intact:EBI-636664	psi-mi:ilrun_human(display_long)|uniprotkb:ILRUN(gene name)|psi-mi:ILRUN(display_short)|uniprotkb:C6orf106(gene name synonym)|uniprotkb:Inflammation and lipid regulator with UBA-like and NBR1-like domains protein(gene name synonym)	psi-mi:m3k1_rat(display_long)|uniprotkb:MAPK/ERK kinase kinase 1(gene name synonym)|uniprotkb:Map3k1(gene name)|psi-mi:Map3k1(display_short)|uniprotkb:Mekk(gene name synonym)|uniprotkb:Mekk1(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9972714|imex:IM-22822-122	author-confidence:Z-score = 11.26	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000196821(gene)|ensembl:ENST00000374023(transcript)|go:"GO:0000407"(phagophore assembly site)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0016236"(macroautophagy)|go:"GO:0016607"(nuclear speck)|go:"GO:0032480"(negative regulation of type I interferon production)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043392"(negative regulation of DNA binding)|go:"GO:0045087"(innate immune response)|go:"GO:0050687"(negative regulation of defense response to virus)|go:"GO:1900181"(negative regulation of protein localization to nucleus)|interpro:IPR009060(UBA-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR032350|interpro:IPR039517|rcsb pdb:6VHI|refseq:NP_073595.2|refseq:NP_077270.1	rgd:620966|refseq:NP_446339.1|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR007527(Zinc finger, SWIM-type)|go:"GO:0000165"(MAPK cascade)|interpro:IPR016024(Armadillo-type fold)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0002011"(morphogenesis of an epithelial sheet)|go:"GO:0003382"(epithelial cell morphogenesis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004706"(JUN kinase kinase kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007254"(JNK cascade)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008432"(JUN kinase binding)|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0016020"(membrane)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0031434"(mitogen-activated protein kinase kinase binding)|go:"GO:0031941"(filamentous actin)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0042060"(wound healing)|go:"GO:0043010"(camera-type eye development)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046625"(sphingolipid binding)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050434"(positive regulation of viral transcription)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0061029"(eyelid development in camera-type eye)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|reactome:R-RNO-166058|reactome:R-RNO-2871796|reactome:R-RNO-975138|reactome:R-RNO-975871|interpro:IPR011989(Armadillo-like helical)|mint:Q62925	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S3|resulting-ptm:Q9H6K1 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:aKj1ZZUKFTQALIMJWSMTol40+l89606	rogid:EwhjYjowkZIAt4UyPcZBUtf9uak10116	intact-crc:6A74C0BD7D6BEAFE|rigid:ELOpxm+l43RhXur6K7oT518cmZw	false	-	sufficient binding region:433-481(IPR013083)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9H6K1	uniprotkb:Q13404	intact:EBI-3939494|uniprotkb:B2R8K7|uniprotkb:Q9BUR9|uniprotkb:Q5VV77|uniprotkb:Q96MG5|ensembl:ENSP00000363135	intact:EBI-1050671|uniprotkb:Q13403|uniprotkb:Q13532|uniprotkb:Q96H34|uniprotkb:Q9GZT0|uniprotkb:Q9GZW1|uniprotkb:Q9H4J3|uniprotkb:Q9H4J4|uniprotkb:Q9UKL1|uniprotkb:Q9UM48|uniprotkb:Q9UM49|uniprotkb:Q9UM50|uniprotkb:Q5TGE3|uniprotkb:E1P629|uniprotkb:Q5TGE0|ensembl:ENSP00000360739	psi-mi:ilrun_human(display_long)|uniprotkb:ILRUN(gene name)|psi-mi:ILRUN(display_short)|uniprotkb:C6orf106(gene name synonym)|uniprotkb:Inflammation and lipid regulator with UBA-like and NBR1-like domains protein(gene name synonym)	psi-mi:ub2v1_human(display_long)|uniprotkb:CROC-1(gene name synonym)|uniprotkb:TRAF6-regulated IKK activator 1 beta Uev1A(gene name synonym)|uniprotkb:P/OKcl.19(orf name)|uniprotkb:UBE2V1(gene name)|psi-mi:UBE2V1(display_short)|uniprotkb:CROC1(gene name synonym)|uniprotkb:UBE2V(gene name synonym)|uniprotkb:UEV1(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9972714|imex:IM-22822-122	author-confidence:Z-score = 11.26	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000196821(gene)|ensembl:ENST00000374023(transcript)|go:"GO:0000407"(phagophore assembly site)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0016236"(macroautophagy)|go:"GO:0016607"(nuclear speck)|go:"GO:0032480"(negative regulation of type I interferon production)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043392"(negative regulation of DNA binding)|go:"GO:0045087"(innate immune response)|go:"GO:0050687"(negative regulation of defense response to virus)|go:"GO:1900181"(negative regulation of protein localization to nucleus)|interpro:IPR009060(UBA-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR032350|interpro:IPR039517|rcsb pdb:6VHI|refseq:NP_073595.2|refseq:NP_077270.1	refseq:NP_001027459.1|refseq:NP_068823.2|refseq:NP_071887.1|refseq:NP_954595.1|refseq:NP_954673.1|refseq:NP_001244322.1|refseq:NP_001244323.1|refseq:NP_001244325.1|ensembl:ENSG00000244687(gene)|ensembl:ENST00000371674(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006282"(regulation of DNA repair)|go:"GO:0006301"(postreplication repair)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0030154"(cell differentiation)|go:"GO:0031371"(ubiquitin conjugating enzyme complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035370"(UBC13-UEV1A complex)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070534"(protein K63-linked ubiquitination)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|rcsb pdb:2A4D|rcsb pdb:2C2V|rcsb pdb:2HLW|rcsb pdb:6D6I|reactome:R-HSA-168638|reactome:R-HSA-168927|reactome:R-HSA-202424|reactome:R-HSA-2871837|reactome:R-HSA-445989|reactome:R-HSA-450302|reactome:R-HSA-450321|reactome:R-HSA-5607764|reactome:R-HSA-9020702|reactome:R-HSA-937039|reactome:R-HSA-937041|reactome:R-HSA-9646399|reactome:R-HSA-975110|reactome:R-HSA-975144|reactome:R-HSA-983168|dip:DIP-41911N	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S3|resulting-ptm:Q9H6K1 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:aKj1ZZUKFTQALIMJWSMTol40+l89606	rogid:x95N7Dj2KIqu5gySX59xLmfthUg9606	intact-crc:6A74C0BD7D6BEAFE|rigid:ELOpxm+l43RhXur6K7oT518cmZw	false	-	his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9H6K1	uniprotkb:P22314	intact:EBI-3939494|uniprotkb:B2R8K7|uniprotkb:Q9BUR9|uniprotkb:Q5VV77|uniprotkb:Q96MG5|ensembl:ENSP00000363135	intact:EBI-709688|uniprotkb:Q96E13|uniprotkb:Q5JRR8|ensembl:ENSP00000338413|ensembl:ENSP00000366568	psi-mi:ilrun_human(display_long)|uniprotkb:ILRUN(gene name)|psi-mi:ILRUN(display_short)|uniprotkb:C6orf106(gene name synonym)|uniprotkb:Inflammation and lipid regulator with UBA-like and NBR1-like domains protein(gene name synonym)	psi-mi:uba1_human(display_long)|uniprotkb:Ubiquitin-activating enzyme E1(gene name synonym)|uniprotkb:Protein A1S9(gene name synonym)|uniprotkb:UBA1(gene name)|psi-mi:UBA1(display_short)|uniprotkb:A1S9T(gene name synonym)|uniprotkb:UBE1(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9972714|imex:IM-22822-122	author-confidence:Z-score = 11.26	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000196821(gene)|ensembl:ENST00000374023(transcript)|go:"GO:0000407"(phagophore assembly site)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0016236"(macroautophagy)|go:"GO:0016607"(nuclear speck)|go:"GO:0032480"(negative regulation of type I interferon production)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043392"(negative regulation of DNA binding)|go:"GO:0045087"(innate immune response)|go:"GO:0050687"(negative regulation of defense response to virus)|go:"GO:1900181"(negative regulation of protein localization to nucleus)|interpro:IPR009060(UBA-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR032350|interpro:IPR039517|rcsb pdb:6VHI|refseq:NP_073595.2|refseq:NP_077270.1	refseq:NP_003325.2|refseq:NP_695012.1|refseq:XP_016885269.1|refseq:XP_016885270.1|dip:DIP-33686N|ensembl:ENSG00000130985(gene)|ensembl:ENST00000335972(transcript)|ensembl:ENST00000377351(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0004839"(ubiquitin activating enzyme activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0032446"(protein modification by small protein conjugation)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000011(Ubiquitin-activating enzyme, E1)|interpro:IPR000594(UBA/THIF-type NAD/FAD binding fold)|interpro:IPR018074|interpro:IPR018075|interpro:IPR018965|interpro:IPR019572|interpro:IPR032418|interpro:IPR032420|interpro:IPR033127|interpro:IPR035985|interpro:IPR038252|interpro:IPR042063|interpro:IPR042302|interpro:IPR042449|mint:P22314|rcsb pdb:4P22|rcsb pdb:6DC6|reactome:R-HSA-8866652|reactome:R-HSA-983168	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S3|resulting-ptm:Q9H6K1 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:aKj1ZZUKFTQALIMJWSMTol40+l89606	rogid:q+vEeA0XLST0Zz173bmEt0dNbDE9606	intact-crc:6A74C0BD7D6BEAFE|rigid:ELOpxm+l43RhXur6K7oT518cmZw	false	-	his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9H6K1	uniprotkb:P61088	intact:EBI-3939494|uniprotkb:B2R8K7|uniprotkb:Q9BUR9|uniprotkb:Q5VV77|uniprotkb:Q96MG5|ensembl:ENSP00000363135	intact:EBI-1052908|uniprotkb:Q16781|uniprotkb:Q53Y81|ensembl:ENSP00000316176	psi-mi:ilrun_human(display_long)|uniprotkb:ILRUN(gene name)|psi-mi:ILRUN(display_short)|uniprotkb:C6orf106(gene name synonym)|uniprotkb:Inflammation and lipid regulator with UBA-like and NBR1-like domains protein(gene name synonym)	psi-mi:ube2n_human(display_long)|uniprotkb:Ubiquitin-protein ligase N(gene name synonym)|uniprotkb:Ubiquitin carrier protein N(gene name synonym)|uniprotkb:Ubc13(gene name synonym)|uniprotkb:Bendless-like ubiquitin-conjugating enzyme(gene name synonym)|uniprotkb:UBE2N(gene name)|psi-mi:UBE2N(display_short)|uniprotkb:BLU(gene name synonym)|uniprotkb:UbcH13(gene name synonym)|uniprotkb:E2 ubiquitin-conjugating enzyme N(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9972714|imex:IM-22822-122	author-confidence:Z-score = 11.26	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000196821(gene)|ensembl:ENST00000374023(transcript)|go:"GO:0000407"(phagophore assembly site)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0016236"(macroautophagy)|go:"GO:0016607"(nuclear speck)|go:"GO:0032480"(negative regulation of type I interferon production)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043392"(negative regulation of DNA binding)|go:"GO:0045087"(innate immune response)|go:"GO:0050687"(negative regulation of defense response to virus)|go:"GO:1900181"(negative regulation of protein localization to nucleus)|interpro:IPR009060(UBA-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR032350|interpro:IPR039517|rcsb pdb:6VHI|refseq:NP_073595.2|refseq:NP_077270.1	refseq:NP_003339.1|dip:DIP-29829N|ensembl:ENSG00000177889(gene)|ensembl:ENST00000318066(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000729"(DNA double-strand break processing)|go:"GO:0001650"(fibrillar center)|go:"GO:0003723"(RNA binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006282"(regulation of DNA repair)|go:"GO:0006301"(postreplication repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016574"(histone ubiquitination)|go:"GO:0031058"(positive regulation of histone modification)|go:"GO:0031372"(UBC13-MMS2 complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033182"(regulation of histone ubiquitination)|go:"GO:0035370"(UBC13-UEV1A complex)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0061631"(ubiquitin conjugating enzyme activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070534"(protein K63-linked ubiquitination)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|interpro:IPR023313|rcsb pdb:1J7D|rcsb pdb:2C2V|rcsb pdb:3HCT|rcsb pdb:3HCU|rcsb pdb:3VON|rcsb pdb:3W31|rcsb pdb:4DHI|rcsb pdb:4DHJ|rcsb pdb:4DHZ|rcsb pdb:4IP3|rcsb pdb:4NR3|rcsb pdb:4NRG|rcsb pdb:4NRI|rcsb pdb:4ONL|rcsb pdb:4ONM|rcsb pdb:4ONN|rcsb pdb:4ORH|rcsb pdb:4TKP|rcsb pdb:4WHV|rcsb pdb:5AIT|rcsb pdb:5AIU|rcsb pdb:5EYA|rcsb pdb:5H7S|rcsb pdb:5VNZ|rcsb pdb:5VO0|rcsb pdb:5YWR|rcsb pdb:6D6I|rcsb pdb:6JKY|rcsb pdb:6KFP|rcsb pdb:6KG6|rcsb pdb:6KL4|rcsb pdb:6LP2|rcsb pdb:6P5B|rcsb pdb:6S53|reactome:R-HSA-168927|reactome:R-HSA-202424|reactome:R-HSA-2871837|reactome:R-HSA-445989|reactome:R-HSA-450302|reactome:R-HSA-450321|reactome:R-HSA-5607764|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-5696395|reactome:R-HSA-69473|reactome:R-HSA-8866654|reactome:R-HSA-9020702|reactome:R-HSA-937039|reactome:R-HSA-937041|reactome:R-HSA-9646399|reactome:R-HSA-975110|reactome:R-HSA-975144|reactome:R-HSA-983168|rcsb pdb:6ULH|rcsb pdb:6UMP|rcsb pdb:6UMS|rcsb pdb:7BBD|rcsb pdb:7BBF|rcsb pdb:7BXG|reactome:R-HSA-1169408|reactome:R-HSA-168638	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S3|resulting-ptm:Q9H6K1 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:aKj1ZZUKFTQALIMJWSMTol40+l89606	rogid:dqdszHlq5FLPHC6UWX6uvkC6Yz89606	intact-crc:6A74C0BD7D6BEAFE|rigid:ELOpxm+l43RhXur6K7oT518cmZw	false	-	his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q62925	uniprotkb:Q13404	intact:EBI-636664	intact:EBI-1050671|uniprotkb:Q13403|uniprotkb:Q13532|uniprotkb:Q96H34|uniprotkb:Q9GZT0|uniprotkb:Q9GZW1|uniprotkb:Q9H4J3|uniprotkb:Q9H4J4|uniprotkb:Q9UKL1|uniprotkb:Q9UM48|uniprotkb:Q9UM49|uniprotkb:Q9UM50|uniprotkb:Q5TGE3|uniprotkb:E1P629|uniprotkb:Q5TGE0|ensembl:ENSP00000360739	psi-mi:m3k1_rat(display_long)|uniprotkb:MAPK/ERK kinase kinase 1(gene name synonym)|uniprotkb:Map3k1(gene name)|psi-mi:Map3k1(display_short)|uniprotkb:Mekk(gene name synonym)|uniprotkb:Mekk1(gene name synonym)	psi-mi:ub2v1_human(display_long)|uniprotkb:CROC-1(gene name synonym)|uniprotkb:TRAF6-regulated IKK activator 1 beta Uev1A(gene name synonym)|uniprotkb:P/OKcl.19(orf name)|uniprotkb:UBE2V1(gene name)|psi-mi:UBE2V1(display_short)|uniprotkb:CROC1(gene name synonym)|uniprotkb:UBE2V(gene name synonym)|uniprotkb:UEV1(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9972764|imex:IM-22822-124	author-confidence:Z-score = 7.50	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:620966|refseq:NP_446339.1|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR007527(Zinc finger, SWIM-type)|go:"GO:0000165"(MAPK cascade)|interpro:IPR016024(Armadillo-type fold)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0002011"(morphogenesis of an epithelial sheet)|go:"GO:0003382"(epithelial cell morphogenesis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004706"(JUN kinase kinase kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007254"(JNK cascade)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008432"(JUN kinase binding)|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0016020"(membrane)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0031434"(mitogen-activated protein kinase kinase binding)|go:"GO:0031941"(filamentous actin)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0042060"(wound healing)|go:"GO:0043010"(camera-type eye development)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046625"(sphingolipid binding)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050434"(positive regulation of viral transcription)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0061029"(eyelid development in camera-type eye)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|reactome:R-RNO-166058|reactome:R-RNO-2871796|reactome:R-RNO-975138|reactome:R-RNO-975871|interpro:IPR011989(Armadillo-like helical)|mint:Q62925	refseq:NP_001027459.1|refseq:NP_068823.2|refseq:NP_071887.1|refseq:NP_954595.1|refseq:NP_954673.1|refseq:NP_001244322.1|refseq:NP_001244323.1|refseq:NP_001244325.1|ensembl:ENSG00000244687(gene)|ensembl:ENST00000371674(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006282"(regulation of DNA repair)|go:"GO:0006301"(postreplication repair)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0030154"(cell differentiation)|go:"GO:0031371"(ubiquitin conjugating enzyme complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035370"(UBC13-UEV1A complex)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070534"(protein K63-linked ubiquitination)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|rcsb pdb:2A4D|rcsb pdb:2C2V|rcsb pdb:2HLW|rcsb pdb:6D6I|reactome:R-HSA-168638|reactome:R-HSA-168927|reactome:R-HSA-202424|reactome:R-HSA-2871837|reactome:R-HSA-445989|reactome:R-HSA-450302|reactome:R-HSA-450321|reactome:R-HSA-5607764|reactome:R-HSA-9020702|reactome:R-HSA-937039|reactome:R-HSA-937041|reactome:R-HSA-9646399|reactome:R-HSA-975110|reactome:R-HSA-975144|reactome:R-HSA-983168|dip:DIP-41911N	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S3|resulting-ptm:Q9H8U3 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:EwhjYjowkZIAt4UyPcZBUtf9uak10116	rogid:x95N7Dj2KIqu5gySX59xLmfthUg9606	intact-crc:D1199724A5152AE2|rigid:LVyZn7irCMXodxCJY8OivqASlLw	false	sufficient binding region:433-481(IPR013083)	his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q62925	uniprotkb:P22314	intact:EBI-636664	intact:EBI-709688|uniprotkb:Q96E13|uniprotkb:Q5JRR8|ensembl:ENSP00000338413|ensembl:ENSP00000366568	psi-mi:m3k1_rat(display_long)|uniprotkb:MAPK/ERK kinase kinase 1(gene name synonym)|uniprotkb:Map3k1(gene name)|psi-mi:Map3k1(display_short)|uniprotkb:Mekk(gene name synonym)|uniprotkb:Mekk1(gene name synonym)	psi-mi:uba1_human(display_long)|uniprotkb:Ubiquitin-activating enzyme E1(gene name synonym)|uniprotkb:Protein A1S9(gene name synonym)|uniprotkb:UBA1(gene name)|psi-mi:UBA1(display_short)|uniprotkb:A1S9T(gene name synonym)|uniprotkb:UBE1(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9972764|imex:IM-22822-124	author-confidence:Z-score = 7.50	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:620966|refseq:NP_446339.1|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR007527(Zinc finger, SWIM-type)|go:"GO:0000165"(MAPK cascade)|interpro:IPR016024(Armadillo-type fold)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0002011"(morphogenesis of an epithelial sheet)|go:"GO:0003382"(epithelial cell morphogenesis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004706"(JUN kinase kinase kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007254"(JNK cascade)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008432"(JUN kinase binding)|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0016020"(membrane)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0031434"(mitogen-activated protein kinase kinase binding)|go:"GO:0031941"(filamentous actin)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0042060"(wound healing)|go:"GO:0043010"(camera-type eye development)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046625"(sphingolipid binding)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050434"(positive regulation of viral transcription)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0061029"(eyelid development in camera-type eye)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|reactome:R-RNO-166058|reactome:R-RNO-2871796|reactome:R-RNO-975138|reactome:R-RNO-975871|interpro:IPR011989(Armadillo-like helical)|mint:Q62925	refseq:NP_003325.2|refseq:NP_695012.1|refseq:XP_016885269.1|refseq:XP_016885270.1|dip:DIP-33686N|ensembl:ENSG00000130985(gene)|ensembl:ENST00000335972(transcript)|ensembl:ENST00000377351(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0004839"(ubiquitin activating enzyme activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0032446"(protein modification by small protein conjugation)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000011(Ubiquitin-activating enzyme, E1)|interpro:IPR000594(UBA/THIF-type NAD/FAD binding fold)|interpro:IPR018074|interpro:IPR018075|interpro:IPR018965|interpro:IPR019572|interpro:IPR032418|interpro:IPR032420|interpro:IPR033127|interpro:IPR035985|interpro:IPR038252|interpro:IPR042063|interpro:IPR042302|interpro:IPR042449|mint:P22314|rcsb pdb:4P22|rcsb pdb:6DC6|reactome:R-HSA-8866652|reactome:R-HSA-983168	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S3|resulting-ptm:Q9H8U3 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:EwhjYjowkZIAt4UyPcZBUtf9uak10116	rogid:q+vEeA0XLST0Zz173bmEt0dNbDE9606	intact-crc:D1199724A5152AE2|rigid:LVyZn7irCMXodxCJY8OivqASlLw	false	sufficient binding region:433-481(IPR013083)	his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q62925	uniprotkb:P61088	intact:EBI-636664	intact:EBI-1052908|uniprotkb:Q16781|uniprotkb:Q53Y81|ensembl:ENSP00000316176	psi-mi:m3k1_rat(display_long)|uniprotkb:MAPK/ERK kinase kinase 1(gene name synonym)|uniprotkb:Map3k1(gene name)|psi-mi:Map3k1(display_short)|uniprotkb:Mekk(gene name synonym)|uniprotkb:Mekk1(gene name synonym)	psi-mi:ube2n_human(display_long)|uniprotkb:Ubiquitin-protein ligase N(gene name synonym)|uniprotkb:Ubiquitin carrier protein N(gene name synonym)|uniprotkb:Ubc13(gene name synonym)|uniprotkb:Bendless-like ubiquitin-conjugating enzyme(gene name synonym)|uniprotkb:UBE2N(gene name)|psi-mi:UBE2N(display_short)|uniprotkb:BLU(gene name synonym)|uniprotkb:UbcH13(gene name synonym)|uniprotkb:E2 ubiquitin-conjugating enzyme N(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9972764|imex:IM-22822-124	author-confidence:Z-score = 7.50	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:620966|refseq:NP_446339.1|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR007527(Zinc finger, SWIM-type)|go:"GO:0000165"(MAPK cascade)|interpro:IPR016024(Armadillo-type fold)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0002011"(morphogenesis of an epithelial sheet)|go:"GO:0003382"(epithelial cell morphogenesis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004706"(JUN kinase kinase kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007254"(JNK cascade)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008432"(JUN kinase binding)|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0016020"(membrane)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0031434"(mitogen-activated protein kinase kinase binding)|go:"GO:0031941"(filamentous actin)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0042060"(wound healing)|go:"GO:0043010"(camera-type eye development)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046625"(sphingolipid binding)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050434"(positive regulation of viral transcription)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0061029"(eyelid development in camera-type eye)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|reactome:R-RNO-166058|reactome:R-RNO-2871796|reactome:R-RNO-975138|reactome:R-RNO-975871|interpro:IPR011989(Armadillo-like helical)|mint:Q62925	refseq:NP_003339.1|dip:DIP-29829N|ensembl:ENSG00000177889(gene)|ensembl:ENST00000318066(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000729"(DNA double-strand break processing)|go:"GO:0001650"(fibrillar center)|go:"GO:0003723"(RNA binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006282"(regulation of DNA repair)|go:"GO:0006301"(postreplication repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016574"(histone ubiquitination)|go:"GO:0031058"(positive regulation of histone modification)|go:"GO:0031372"(UBC13-MMS2 complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033182"(regulation of histone ubiquitination)|go:"GO:0035370"(UBC13-UEV1A complex)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0061631"(ubiquitin conjugating enzyme activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070534"(protein K63-linked ubiquitination)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|interpro:IPR023313|rcsb pdb:1J7D|rcsb pdb:2C2V|rcsb pdb:3HCT|rcsb pdb:3HCU|rcsb pdb:3VON|rcsb pdb:3W31|rcsb pdb:4DHI|rcsb pdb:4DHJ|rcsb pdb:4DHZ|rcsb pdb:4IP3|rcsb pdb:4NR3|rcsb pdb:4NRG|rcsb pdb:4NRI|rcsb pdb:4ONL|rcsb pdb:4ONM|rcsb pdb:4ONN|rcsb pdb:4ORH|rcsb pdb:4TKP|rcsb pdb:4WHV|rcsb pdb:5AIT|rcsb pdb:5AIU|rcsb pdb:5EYA|rcsb pdb:5H7S|rcsb pdb:5VNZ|rcsb pdb:5VO0|rcsb pdb:5YWR|rcsb pdb:6D6I|rcsb pdb:6JKY|rcsb pdb:6KFP|rcsb pdb:6KG6|rcsb pdb:6KL4|rcsb pdb:6LP2|rcsb pdb:6P5B|rcsb pdb:6S53|reactome:R-HSA-168927|reactome:R-HSA-202424|reactome:R-HSA-2871837|reactome:R-HSA-445989|reactome:R-HSA-450302|reactome:R-HSA-450321|reactome:R-HSA-5607764|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-5696395|reactome:R-HSA-69473|reactome:R-HSA-8866654|reactome:R-HSA-9020702|reactome:R-HSA-937039|reactome:R-HSA-937041|reactome:R-HSA-9646399|reactome:R-HSA-975110|reactome:R-HSA-975144|reactome:R-HSA-983168|rcsb pdb:6ULH|rcsb pdb:6UMP|rcsb pdb:6UMS|rcsb pdb:7BBD|rcsb pdb:7BBF|rcsb pdb:7BXG|reactome:R-HSA-1169408|reactome:R-HSA-168638	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S3|resulting-ptm:Q9H8U3 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:EwhjYjowkZIAt4UyPcZBUtf9uak10116	rogid:dqdszHlq5FLPHC6UWX6uvkC6Yz89606	intact-crc:D1199724A5152AE2|rigid:LVyZn7irCMXodxCJY8OivqASlLw	false	sufficient binding region:433-481(IPR013083)	his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q62925	uniprotkb:Q9H8U3	intact:EBI-636664	intact:EBI-725171|uniprotkb:Q5SZZ0|uniprotkb:Q5SZZ1|ensembl:ENSP00000287218	psi-mi:m3k1_rat(display_long)|uniprotkb:MAPK/ERK kinase kinase 1(gene name synonym)|uniprotkb:Map3k1(gene name)|psi-mi:Map3k1(display_short)|uniprotkb:Mekk(gene name synonym)|uniprotkb:Mekk1(gene name synonym)	psi-mi:zfan3_human(display_long)|uniprotkb:ZFAND3(gene name)|psi-mi:ZFAND3(display_short)|uniprotkb:TEX27(gene name synonym)|uniprotkb:Testis-expressed protein 27(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9972764|imex:IM-22822-124	author-confidence:Z-score = 7.50	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:620966|refseq:NP_446339.1|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR007527(Zinc finger, SWIM-type)|go:"GO:0000165"(MAPK cascade)|interpro:IPR016024(Armadillo-type fold)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0002011"(morphogenesis of an epithelial sheet)|go:"GO:0003382"(epithelial cell morphogenesis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004706"(JUN kinase kinase kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007254"(JNK cascade)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008432"(JUN kinase binding)|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0016020"(membrane)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0031434"(mitogen-activated protein kinase kinase binding)|go:"GO:0031941"(filamentous actin)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0042060"(wound healing)|go:"GO:0043010"(camera-type eye development)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046625"(sphingolipid binding)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050434"(positive regulation of viral transcription)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0061029"(eyelid development in camera-type eye)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|reactome:R-RNO-166058|reactome:R-RNO-2871796|reactome:R-RNO-975138|reactome:R-RNO-975871|interpro:IPR011989(Armadillo-like helical)|mint:Q62925	refseq:NP_068762.1|ensembl:ENSG00000156639(gene)|ensembl:ENST00000287218(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0008270"(zinc ion binding)|interpro:IPR000058(Zinc finger, AN1-type)|interpro:IPR002653(Zinc finger, A20-type)|interpro:IPR035896|rcsb pdb:1X4W	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S3|resulting-ptm:Q9H8U3 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:EwhjYjowkZIAt4UyPcZBUtf9uak10116	rogid:9KvddyIb2EqfoE5mgRxlWYvE4D49606	intact-crc:D1199724A5152AE2|rigid:LVyZn7irCMXodxCJY8OivqASlLw	false	sufficient binding region:433-481(IPR013083)	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q62925	uniprotkb:Q13404	intact:EBI-636664	intact:EBI-1050671|uniprotkb:Q13403|uniprotkb:Q13532|uniprotkb:Q96H34|uniprotkb:Q9GZT0|uniprotkb:Q9GZW1|uniprotkb:Q9H4J3|uniprotkb:Q9H4J4|uniprotkb:Q9UKL1|uniprotkb:Q9UM48|uniprotkb:Q9UM49|uniprotkb:Q9UM50|uniprotkb:Q5TGE3|uniprotkb:E1P629|uniprotkb:Q5TGE0|ensembl:ENSP00000360739	psi-mi:m3k1_rat(display_long)|uniprotkb:MAPK/ERK kinase kinase 1(gene name synonym)|uniprotkb:Map3k1(gene name)|psi-mi:Map3k1(display_short)|uniprotkb:Mekk(gene name synonym)|uniprotkb:Mekk1(gene name synonym)	psi-mi:ub2v1_human(display_long)|uniprotkb:CROC-1(gene name synonym)|uniprotkb:TRAF6-regulated IKK activator 1 beta Uev1A(gene name synonym)|uniprotkb:P/OKcl.19(orf name)|uniprotkb:UBE2V1(gene name)|psi-mi:UBE2V1(display_short)|uniprotkb:CROC1(gene name synonym)|uniprotkb:UBE2V(gene name synonym)|uniprotkb:UEV1(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9972789|imex:IM-22822-125	author-confidence:Z-score = 10.76	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:620966|refseq:NP_446339.1|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR007527(Zinc finger, SWIM-type)|go:"GO:0000165"(MAPK cascade)|interpro:IPR016024(Armadillo-type fold)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0002011"(morphogenesis of an epithelial sheet)|go:"GO:0003382"(epithelial cell morphogenesis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004706"(JUN kinase kinase kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007254"(JNK cascade)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008432"(JUN kinase binding)|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0016020"(membrane)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0031434"(mitogen-activated protein kinase kinase binding)|go:"GO:0031941"(filamentous actin)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0042060"(wound healing)|go:"GO:0043010"(camera-type eye development)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046625"(sphingolipid binding)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050434"(positive regulation of viral transcription)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0061029"(eyelid development in camera-type eye)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|reactome:R-RNO-166058|reactome:R-RNO-2871796|reactome:R-RNO-975138|reactome:R-RNO-975871|interpro:IPR011989(Armadillo-like helical)|mint:Q62925	refseq:NP_001027459.1|refseq:NP_068823.2|refseq:NP_071887.1|refseq:NP_954595.1|refseq:NP_954673.1|refseq:NP_001244322.1|refseq:NP_001244323.1|refseq:NP_001244325.1|ensembl:ENSG00000244687(gene)|ensembl:ENST00000371674(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006282"(regulation of DNA repair)|go:"GO:0006301"(postreplication repair)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0030154"(cell differentiation)|go:"GO:0031371"(ubiquitin conjugating enzyme complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035370"(UBC13-UEV1A complex)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070534"(protein K63-linked ubiquitination)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|rcsb pdb:2A4D|rcsb pdb:2C2V|rcsb pdb:2HLW|rcsb pdb:6D6I|reactome:R-HSA-168638|reactome:R-HSA-168927|reactome:R-HSA-202424|reactome:R-HSA-2871837|reactome:R-HSA-445989|reactome:R-HSA-450302|reactome:R-HSA-450321|reactome:R-HSA-5607764|reactome:R-HSA-9020702|reactome:R-HSA-937039|reactome:R-HSA-937041|reactome:R-HSA-9646399|reactome:R-HSA-975110|reactome:R-HSA-975144|reactome:R-HSA-983168|dip:DIP-41911N	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S3|resulting-ptm:Q9NRR5 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:EwhjYjowkZIAt4UyPcZBUtf9uak10116	rogid:x95N7Dj2KIqu5gySX59xLmfthUg9606	intact-crc:B50FC9AC8664F922|rigid:q0MdQXNyWwvYSr2u4JsC/7FEEdU	false	sufficient binding region:433-481(IPR013083)	his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q62925	uniprotkb:P22314	intact:EBI-636664	intact:EBI-709688|uniprotkb:Q96E13|uniprotkb:Q5JRR8|ensembl:ENSP00000338413|ensembl:ENSP00000366568	psi-mi:m3k1_rat(display_long)|uniprotkb:MAPK/ERK kinase kinase 1(gene name synonym)|uniprotkb:Map3k1(gene name)|psi-mi:Map3k1(display_short)|uniprotkb:Mekk(gene name synonym)|uniprotkb:Mekk1(gene name synonym)	psi-mi:uba1_human(display_long)|uniprotkb:Ubiquitin-activating enzyme E1(gene name synonym)|uniprotkb:Protein A1S9(gene name synonym)|uniprotkb:UBA1(gene name)|psi-mi:UBA1(display_short)|uniprotkb:A1S9T(gene name synonym)|uniprotkb:UBE1(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9972789|imex:IM-22822-125	author-confidence:Z-score = 10.76	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:620966|refseq:NP_446339.1|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR007527(Zinc finger, SWIM-type)|go:"GO:0000165"(MAPK cascade)|interpro:IPR016024(Armadillo-type fold)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0002011"(morphogenesis of an epithelial sheet)|go:"GO:0003382"(epithelial cell morphogenesis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004706"(JUN kinase kinase kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007254"(JNK cascade)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008432"(JUN kinase binding)|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0016020"(membrane)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0031434"(mitogen-activated protein kinase kinase binding)|go:"GO:0031941"(filamentous actin)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0042060"(wound healing)|go:"GO:0043010"(camera-type eye development)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046625"(sphingolipid binding)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050434"(positive regulation of viral transcription)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0061029"(eyelid development in camera-type eye)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|reactome:R-RNO-166058|reactome:R-RNO-2871796|reactome:R-RNO-975138|reactome:R-RNO-975871|interpro:IPR011989(Armadillo-like helical)|mint:Q62925	refseq:NP_003325.2|refseq:NP_695012.1|refseq:XP_016885269.1|refseq:XP_016885270.1|dip:DIP-33686N|ensembl:ENSG00000130985(gene)|ensembl:ENST00000335972(transcript)|ensembl:ENST00000377351(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0004839"(ubiquitin activating enzyme activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0032446"(protein modification by small protein conjugation)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000011(Ubiquitin-activating enzyme, E1)|interpro:IPR000594(UBA/THIF-type NAD/FAD binding fold)|interpro:IPR018074|interpro:IPR018075|interpro:IPR018965|interpro:IPR019572|interpro:IPR032418|interpro:IPR032420|interpro:IPR033127|interpro:IPR035985|interpro:IPR038252|interpro:IPR042063|interpro:IPR042302|interpro:IPR042449|mint:P22314|rcsb pdb:4P22|rcsb pdb:6DC6|reactome:R-HSA-8866652|reactome:R-HSA-983168	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S3|resulting-ptm:Q9NRR5 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:EwhjYjowkZIAt4UyPcZBUtf9uak10116	rogid:q+vEeA0XLST0Zz173bmEt0dNbDE9606	intact-crc:B50FC9AC8664F922|rigid:q0MdQXNyWwvYSr2u4JsC/7FEEdU	false	sufficient binding region:433-481(IPR013083)	his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q62925	uniprotkb:P61088	intact:EBI-636664	intact:EBI-1052908|uniprotkb:Q16781|uniprotkb:Q53Y81|ensembl:ENSP00000316176	psi-mi:m3k1_rat(display_long)|uniprotkb:MAPK/ERK kinase kinase 1(gene name synonym)|uniprotkb:Map3k1(gene name)|psi-mi:Map3k1(display_short)|uniprotkb:Mekk(gene name synonym)|uniprotkb:Mekk1(gene name synonym)	psi-mi:ube2n_human(display_long)|uniprotkb:Ubiquitin-protein ligase N(gene name synonym)|uniprotkb:Ubiquitin carrier protein N(gene name synonym)|uniprotkb:Ubc13(gene name synonym)|uniprotkb:Bendless-like ubiquitin-conjugating enzyme(gene name synonym)|uniprotkb:UBE2N(gene name)|psi-mi:UBE2N(display_short)|uniprotkb:BLU(gene name synonym)|uniprotkb:UbcH13(gene name synonym)|uniprotkb:E2 ubiquitin-conjugating enzyme N(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9972789|imex:IM-22822-125	author-confidence:Z-score = 10.76	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:620966|refseq:NP_446339.1|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR007527(Zinc finger, SWIM-type)|go:"GO:0000165"(MAPK cascade)|interpro:IPR016024(Armadillo-type fold)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0002011"(morphogenesis of an epithelial sheet)|go:"GO:0003382"(epithelial cell morphogenesis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004706"(JUN kinase kinase kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007254"(JNK cascade)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008432"(JUN kinase binding)|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0016020"(membrane)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0031434"(mitogen-activated protein kinase kinase binding)|go:"GO:0031941"(filamentous actin)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0042060"(wound healing)|go:"GO:0043010"(camera-type eye development)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046625"(sphingolipid binding)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050434"(positive regulation of viral transcription)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0061029"(eyelid development in camera-type eye)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|reactome:R-RNO-166058|reactome:R-RNO-2871796|reactome:R-RNO-975138|reactome:R-RNO-975871|interpro:IPR011989(Armadillo-like helical)|mint:Q62925	refseq:NP_003339.1|dip:DIP-29829N|ensembl:ENSG00000177889(gene)|ensembl:ENST00000318066(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000729"(DNA double-strand break processing)|go:"GO:0001650"(fibrillar center)|go:"GO:0003723"(RNA binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006282"(regulation of DNA repair)|go:"GO:0006301"(postreplication repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016574"(histone ubiquitination)|go:"GO:0031058"(positive regulation of histone modification)|go:"GO:0031372"(UBC13-MMS2 complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033182"(regulation of histone ubiquitination)|go:"GO:0035370"(UBC13-UEV1A complex)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0061631"(ubiquitin conjugating enzyme activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070534"(protein K63-linked ubiquitination)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|interpro:IPR023313|rcsb pdb:1J7D|rcsb pdb:2C2V|rcsb pdb:3HCT|rcsb pdb:3HCU|rcsb pdb:3VON|rcsb pdb:3W31|rcsb pdb:4DHI|rcsb pdb:4DHJ|rcsb pdb:4DHZ|rcsb pdb:4IP3|rcsb pdb:4NR3|rcsb pdb:4NRG|rcsb pdb:4NRI|rcsb pdb:4ONL|rcsb pdb:4ONM|rcsb pdb:4ONN|rcsb pdb:4ORH|rcsb pdb:4TKP|rcsb pdb:4WHV|rcsb pdb:5AIT|rcsb pdb:5AIU|rcsb pdb:5EYA|rcsb pdb:5H7S|rcsb pdb:5VNZ|rcsb pdb:5VO0|rcsb pdb:5YWR|rcsb pdb:6D6I|rcsb pdb:6JKY|rcsb pdb:6KFP|rcsb pdb:6KG6|rcsb pdb:6KL4|rcsb pdb:6LP2|rcsb pdb:6P5B|rcsb pdb:6S53|reactome:R-HSA-168927|reactome:R-HSA-202424|reactome:R-HSA-2871837|reactome:R-HSA-445989|reactome:R-HSA-450302|reactome:R-HSA-450321|reactome:R-HSA-5607764|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-5696395|reactome:R-HSA-69473|reactome:R-HSA-8866654|reactome:R-HSA-9020702|reactome:R-HSA-937039|reactome:R-HSA-937041|reactome:R-HSA-9646399|reactome:R-HSA-975110|reactome:R-HSA-975144|reactome:R-HSA-983168|rcsb pdb:6ULH|rcsb pdb:6UMP|rcsb pdb:6UMS|rcsb pdb:7BBD|rcsb pdb:7BBF|rcsb pdb:7BXG|reactome:R-HSA-1169408|reactome:R-HSA-168638	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S3|resulting-ptm:Q9NRR5 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:EwhjYjowkZIAt4UyPcZBUtf9uak10116	rogid:dqdszHlq5FLPHC6UWX6uvkC6Yz89606	intact-crc:B50FC9AC8664F922|rigid:q0MdQXNyWwvYSr2u4JsC/7FEEdU	false	sufficient binding region:433-481(IPR013083)	his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q62925	uniprotkb:Q9NRR5	intact:EBI-636664	intact:EBI-711226|intact:EBI-722657|uniprotkb:Q9BR98|uniprotkb:Q9UHX4|ensembl:ENSP00000357292|uniprotkb:Q5VYA1|uniprotkb:B2RAY7|uniprotkb:A6ND44|uniprotkb:Q5VYA0	psi-mi:m3k1_rat(display_long)|uniprotkb:MAPK/ERK kinase kinase 1(gene name synonym)|uniprotkb:Map3k1(gene name)|psi-mi:Map3k1(display_short)|uniprotkb:Mekk(gene name synonym)|uniprotkb:Mekk1(gene name synonym)	psi-mi:ubql4_human(display_long)|uniprotkb:UBQLN4(gene name)|psi-mi:UBQLN4(display_short)|uniprotkb:C1orf6(gene name synonym)|uniprotkb:UBIN(gene name synonym)|uniprotkb:Ataxin-1 ubiquitin-like-interacting protein A1U(gene name synonym)|uniprotkb:Ataxin-1 interacting ubiquitin-like protein(gene name synonym)|uniprotkb:CIP75(gene name synonym)|uniprotkb:Connexin43-interacting protein of 75 kDa(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9972789|imex:IM-22822-125	author-confidence:Z-score = 10.76	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:620966|refseq:NP_446339.1|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR007527(Zinc finger, SWIM-type)|go:"GO:0000165"(MAPK cascade)|interpro:IPR016024(Armadillo-type fold)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0002011"(morphogenesis of an epithelial sheet)|go:"GO:0003382"(epithelial cell morphogenesis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004706"(JUN kinase kinase kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007254"(JNK cascade)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008432"(JUN kinase binding)|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0016020"(membrane)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0031434"(mitogen-activated protein kinase kinase binding)|go:"GO:0031941"(filamentous actin)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0042060"(wound healing)|go:"GO:0043010"(camera-type eye development)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046625"(sphingolipid binding)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050434"(positive regulation of viral transcription)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0061029"(eyelid development in camera-type eye)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|reactome:R-RNO-166058|reactome:R-RNO-2871796|reactome:R-RNO-975138|reactome:R-RNO-975871|interpro:IPR011989(Armadillo-like helical)|mint:Q62925	refseq:NP_001291271.1|refseq:NP_064516.2|ensembl:ENSG00000160803(gene)|interpro:IPR029071|ensembl:ENST00000368309(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005776"(autophagosome)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006914"(autophagy)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031593"(polyubiquitin modification-dependent protein binding)|go:"GO:0032434"(regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0036435"(K48-linked polyubiquitin modification-dependent protein binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0090734"(site of DNA damage)|go:"GO:1901097"(negative regulation of autophagosome maturation)|go:"GO:2000042"(negative regulation of double-strand break repair via homologous recombination)|interpro:IPR000626(Ubiquitin)|interpro:IPR006636(Heat shock chaperonin-binding)|interpro:IPR009060(UBA-like)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S3|resulting-ptm:Q9NRR5 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:EwhjYjowkZIAt4UyPcZBUtf9uak10116	rogid:H/kLIS8aSMue9jYu1Q4qTcBLt5o9606	intact-crc:B50FC9AC8664F922|rigid:q0MdQXNyWwvYSr2u4JsC/7FEEdU	false	sufficient binding region:433-481(IPR013083)	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q62925	uniprotkb:Q9NS91	intact:EBI-636664	intact:EBI-2339393|uniprotkb:Q9NRT6|uniprotkb:Q58F55|ensembl:ENSP00000264926	psi-mi:m3k1_rat(display_long)|uniprotkb:MAPK/ERK kinase kinase 1(gene name synonym)|uniprotkb:Map3k1(gene name)|psi-mi:Map3k1(display_short)|uniprotkb:Mekk(gene name synonym)|uniprotkb:Mekk1(gene name synonym)	psi-mi:rad18_human(display_long)|uniprotkb:RAD18(gene name)|psi-mi:RAD18(display_short)|uniprotkb:RNF73(gene name synonym)|uniprotkb:Postreplication repair protein RAD18(gene name synonym)|uniprotkb:RING finger protein 73(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase RAD18(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9972814|imex:IM-22822-126	author-confidence:Z-score = 8.14	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:620966|refseq:NP_446339.1|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR007527(Zinc finger, SWIM-type)|go:"GO:0000165"(MAPK cascade)|interpro:IPR016024(Armadillo-type fold)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0002011"(morphogenesis of an epithelial sheet)|go:"GO:0003382"(epithelial cell morphogenesis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004706"(JUN kinase kinase kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007254"(JNK cascade)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008432"(JUN kinase binding)|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0016020"(membrane)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0031434"(mitogen-activated protein kinase kinase binding)|go:"GO:0031941"(filamentous actin)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0042060"(wound healing)|go:"GO:0043010"(camera-type eye development)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046625"(sphingolipid binding)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050434"(positive regulation of viral transcription)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0061029"(eyelid development in camera-type eye)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|reactome:R-RNO-166058|reactome:R-RNO-2871796|reactome:R-RNO-975138|reactome:R-RNO-975871|interpro:IPR011989(Armadillo-like helical)|mint:Q62925	refseq:NP_064550.3|ensembl:ENSP00000264926|dip:DIP-29831N|ensembl:ENSG00000070950(gene)|ensembl:ENST00000264926(transcript)|go:"GO:0000403"(Y-form DNA binding)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005657"(replication fork)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0006281"(DNA repair)|go:"GO:0006301"(postreplication repair)|go:"GO:0006513"(protein monoubiquitination)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0016604"(nuclear body)|go:"GO:0031593"(polyubiquitin modification-dependent protein binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0035861"(site of double-strand break)|go:"GO:0042405"(nuclear inclusion body)|go:"GO:0042802"(identical protein binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0051984"(positive regulation of chromosome segregation)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0097505"(Rad6-Rad18 complex)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR003034(DNA-binding SAP)|interpro:IPR006642(Zinc finger, Rad18-type putative)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR036361|interpro:IPR039577|mint:Q9NS91|rcsb pdb:2MRE|rcsb pdb:2MRF|rcsb pdb:2Y43|rcsb pdb:2YBF|rcsb pdb:5VF0|reactome:R-HSA-110314|reactome:R-HSA-8866654|go:"GO:0060548"(negative regulation of cell death)	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S3|resulting-ptm:Q9NS91 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:EwhjYjowkZIAt4UyPcZBUtf9uak10116	rogid:/HmKCLqG1BxzmIWCgVpOw/gzJc49606	intact-crc:92274563212F2EED|rigid:sYkNSXnrUWqAQCuIlHPJ4beeiL4	false	sufficient binding region:433-481(IPR013083)	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q62925	uniprotkb:Q13404	intact:EBI-636664	intact:EBI-1050671|uniprotkb:Q13403|uniprotkb:Q13532|uniprotkb:Q96H34|uniprotkb:Q9GZT0|uniprotkb:Q9GZW1|uniprotkb:Q9H4J3|uniprotkb:Q9H4J4|uniprotkb:Q9UKL1|uniprotkb:Q9UM48|uniprotkb:Q9UM49|uniprotkb:Q9UM50|uniprotkb:Q5TGE3|uniprotkb:E1P629|uniprotkb:Q5TGE0|ensembl:ENSP00000360739	psi-mi:m3k1_rat(display_long)|uniprotkb:MAPK/ERK kinase kinase 1(gene name synonym)|uniprotkb:Map3k1(gene name)|psi-mi:Map3k1(display_short)|uniprotkb:Mekk(gene name synonym)|uniprotkb:Mekk1(gene name synonym)	psi-mi:ub2v1_human(display_long)|uniprotkb:CROC-1(gene name synonym)|uniprotkb:TRAF6-regulated IKK activator 1 beta Uev1A(gene name synonym)|uniprotkb:P/OKcl.19(orf name)|uniprotkb:UBE2V1(gene name)|psi-mi:UBE2V1(display_short)|uniprotkb:CROC1(gene name synonym)|uniprotkb:UBE2V(gene name synonym)|uniprotkb:UEV1(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9972814|imex:IM-22822-126	author-confidence:Z-score = 8.14	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:620966|refseq:NP_446339.1|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR007527(Zinc finger, SWIM-type)|go:"GO:0000165"(MAPK cascade)|interpro:IPR016024(Armadillo-type fold)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0002011"(morphogenesis of an epithelial sheet)|go:"GO:0003382"(epithelial cell morphogenesis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004706"(JUN kinase kinase kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007254"(JNK cascade)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008432"(JUN kinase binding)|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0016020"(membrane)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0031434"(mitogen-activated protein kinase kinase binding)|go:"GO:0031941"(filamentous actin)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0042060"(wound healing)|go:"GO:0043010"(camera-type eye development)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046625"(sphingolipid binding)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050434"(positive regulation of viral transcription)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0061029"(eyelid development in camera-type eye)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|reactome:R-RNO-166058|reactome:R-RNO-2871796|reactome:R-RNO-975138|reactome:R-RNO-975871|interpro:IPR011989(Armadillo-like helical)|mint:Q62925	refseq:NP_001027459.1|refseq:NP_068823.2|refseq:NP_071887.1|refseq:NP_954595.1|refseq:NP_954673.1|refseq:NP_001244322.1|refseq:NP_001244323.1|refseq:NP_001244325.1|ensembl:ENSG00000244687(gene)|ensembl:ENST00000371674(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006282"(regulation of DNA repair)|go:"GO:0006301"(postreplication repair)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0030154"(cell differentiation)|go:"GO:0031371"(ubiquitin conjugating enzyme complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035370"(UBC13-UEV1A complex)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070534"(protein K63-linked ubiquitination)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|rcsb pdb:2A4D|rcsb pdb:2C2V|rcsb pdb:2HLW|rcsb pdb:6D6I|reactome:R-HSA-168638|reactome:R-HSA-168927|reactome:R-HSA-202424|reactome:R-HSA-2871837|reactome:R-HSA-445989|reactome:R-HSA-450302|reactome:R-HSA-450321|reactome:R-HSA-5607764|reactome:R-HSA-9020702|reactome:R-HSA-937039|reactome:R-HSA-937041|reactome:R-HSA-9646399|reactome:R-HSA-975110|reactome:R-HSA-975144|reactome:R-HSA-983168|dip:DIP-41911N	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S3|resulting-ptm:Q9NS91 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:EwhjYjowkZIAt4UyPcZBUtf9uak10116	rogid:x95N7Dj2KIqu5gySX59xLmfthUg9606	intact-crc:92274563212F2EED|rigid:sYkNSXnrUWqAQCuIlHPJ4beeiL4	false	sufficient binding region:433-481(IPR013083)	his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q62925	uniprotkb:P22314	intact:EBI-636664	intact:EBI-709688|uniprotkb:Q96E13|uniprotkb:Q5JRR8|ensembl:ENSP00000338413|ensembl:ENSP00000366568	psi-mi:m3k1_rat(display_long)|uniprotkb:MAPK/ERK kinase kinase 1(gene name synonym)|uniprotkb:Map3k1(gene name)|psi-mi:Map3k1(display_short)|uniprotkb:Mekk(gene name synonym)|uniprotkb:Mekk1(gene name synonym)	psi-mi:uba1_human(display_long)|uniprotkb:Ubiquitin-activating enzyme E1(gene name synonym)|uniprotkb:Protein A1S9(gene name synonym)|uniprotkb:UBA1(gene name)|psi-mi:UBA1(display_short)|uniprotkb:A1S9T(gene name synonym)|uniprotkb:UBE1(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9972814|imex:IM-22822-126	author-confidence:Z-score = 8.14	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:620966|refseq:NP_446339.1|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR007527(Zinc finger, SWIM-type)|go:"GO:0000165"(MAPK cascade)|interpro:IPR016024(Armadillo-type fold)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0002011"(morphogenesis of an epithelial sheet)|go:"GO:0003382"(epithelial cell morphogenesis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004706"(JUN kinase kinase kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007254"(JNK cascade)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008432"(JUN kinase binding)|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0016020"(membrane)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0031434"(mitogen-activated protein kinase kinase binding)|go:"GO:0031941"(filamentous actin)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0042060"(wound healing)|go:"GO:0043010"(camera-type eye development)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046625"(sphingolipid binding)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050434"(positive regulation of viral transcription)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0061029"(eyelid development in camera-type eye)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|reactome:R-RNO-166058|reactome:R-RNO-2871796|reactome:R-RNO-975138|reactome:R-RNO-975871|interpro:IPR011989(Armadillo-like helical)|mint:Q62925	refseq:NP_003325.2|refseq:NP_695012.1|refseq:XP_016885269.1|refseq:XP_016885270.1|dip:DIP-33686N|ensembl:ENSG00000130985(gene)|ensembl:ENST00000335972(transcript)|ensembl:ENST00000377351(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0004839"(ubiquitin activating enzyme activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0032446"(protein modification by small protein conjugation)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000011(Ubiquitin-activating enzyme, E1)|interpro:IPR000594(UBA/THIF-type NAD/FAD binding fold)|interpro:IPR018074|interpro:IPR018075|interpro:IPR018965|interpro:IPR019572|interpro:IPR032418|interpro:IPR032420|interpro:IPR033127|interpro:IPR035985|interpro:IPR038252|interpro:IPR042063|interpro:IPR042302|interpro:IPR042449|mint:P22314|rcsb pdb:4P22|rcsb pdb:6DC6|reactome:R-HSA-8866652|reactome:R-HSA-983168	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S3|resulting-ptm:Q9NS91 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:EwhjYjowkZIAt4UyPcZBUtf9uak10116	rogid:q+vEeA0XLST0Zz173bmEt0dNbDE9606	intact-crc:92274563212F2EED|rigid:sYkNSXnrUWqAQCuIlHPJ4beeiL4	false	sufficient binding region:433-481(IPR013083)	his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q62925	uniprotkb:P61088	intact:EBI-636664	intact:EBI-1052908|uniprotkb:Q16781|uniprotkb:Q53Y81|ensembl:ENSP00000316176	psi-mi:m3k1_rat(display_long)|uniprotkb:MAPK/ERK kinase kinase 1(gene name synonym)|uniprotkb:Map3k1(gene name)|psi-mi:Map3k1(display_short)|uniprotkb:Mekk(gene name synonym)|uniprotkb:Mekk1(gene name synonym)	psi-mi:ube2n_human(display_long)|uniprotkb:Ubiquitin-protein ligase N(gene name synonym)|uniprotkb:Ubiquitin carrier protein N(gene name synonym)|uniprotkb:Ubc13(gene name synonym)|uniprotkb:Bendless-like ubiquitin-conjugating enzyme(gene name synonym)|uniprotkb:UBE2N(gene name)|psi-mi:UBE2N(display_short)|uniprotkb:BLU(gene name synonym)|uniprotkb:UbcH13(gene name synonym)|uniprotkb:E2 ubiquitin-conjugating enzyme N(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9972814|imex:IM-22822-126	author-confidence:Z-score = 8.14	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:620966|refseq:NP_446339.1|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR007527(Zinc finger, SWIM-type)|go:"GO:0000165"(MAPK cascade)|interpro:IPR016024(Armadillo-type fold)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0002011"(morphogenesis of an epithelial sheet)|go:"GO:0003382"(epithelial cell morphogenesis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004706"(JUN kinase kinase kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007254"(JNK cascade)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008432"(JUN kinase binding)|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0016020"(membrane)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0031434"(mitogen-activated protein kinase kinase binding)|go:"GO:0031941"(filamentous actin)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0042060"(wound healing)|go:"GO:0043010"(camera-type eye development)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046625"(sphingolipid binding)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050434"(positive regulation of viral transcription)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0061029"(eyelid development in camera-type eye)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|reactome:R-RNO-166058|reactome:R-RNO-2871796|reactome:R-RNO-975138|reactome:R-RNO-975871|interpro:IPR011989(Armadillo-like helical)|mint:Q62925	refseq:NP_003339.1|dip:DIP-29829N|ensembl:ENSG00000177889(gene)|ensembl:ENST00000318066(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000729"(DNA double-strand break processing)|go:"GO:0001650"(fibrillar center)|go:"GO:0003723"(RNA binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006282"(regulation of DNA repair)|go:"GO:0006301"(postreplication repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016574"(histone ubiquitination)|go:"GO:0031058"(positive regulation of histone modification)|go:"GO:0031372"(UBC13-MMS2 complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033182"(regulation of histone ubiquitination)|go:"GO:0035370"(UBC13-UEV1A complex)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0061631"(ubiquitin conjugating enzyme activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070534"(protein K63-linked ubiquitination)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|interpro:IPR023313|rcsb pdb:1J7D|rcsb pdb:2C2V|rcsb pdb:3HCT|rcsb pdb:3HCU|rcsb pdb:3VON|rcsb pdb:3W31|rcsb pdb:4DHI|rcsb pdb:4DHJ|rcsb pdb:4DHZ|rcsb pdb:4IP3|rcsb pdb:4NR3|rcsb pdb:4NRG|rcsb pdb:4NRI|rcsb pdb:4ONL|rcsb pdb:4ONM|rcsb pdb:4ONN|rcsb pdb:4ORH|rcsb pdb:4TKP|rcsb pdb:4WHV|rcsb pdb:5AIT|rcsb pdb:5AIU|rcsb pdb:5EYA|rcsb pdb:5H7S|rcsb pdb:5VNZ|rcsb pdb:5VO0|rcsb pdb:5YWR|rcsb pdb:6D6I|rcsb pdb:6JKY|rcsb pdb:6KFP|rcsb pdb:6KG6|rcsb pdb:6KL4|rcsb pdb:6LP2|rcsb pdb:6P5B|rcsb pdb:6S53|reactome:R-HSA-168927|reactome:R-HSA-202424|reactome:R-HSA-2871837|reactome:R-HSA-445989|reactome:R-HSA-450302|reactome:R-HSA-450321|reactome:R-HSA-5607764|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-5696395|reactome:R-HSA-69473|reactome:R-HSA-8866654|reactome:R-HSA-9020702|reactome:R-HSA-937039|reactome:R-HSA-937041|reactome:R-HSA-9646399|reactome:R-HSA-975110|reactome:R-HSA-975144|reactome:R-HSA-983168|rcsb pdb:6ULH|rcsb pdb:6UMP|rcsb pdb:6UMS|rcsb pdb:7BBD|rcsb pdb:7BBF|rcsb pdb:7BXG|reactome:R-HSA-1169408|reactome:R-HSA-168638	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S3|resulting-ptm:Q9NS91 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:EwhjYjowkZIAt4UyPcZBUtf9uak10116	rogid:dqdszHlq5FLPHC6UWX6uvkC6Yz89606	intact-crc:92274563212F2EED|rigid:sYkNSXnrUWqAQCuIlHPJ4beeiL4	false	sufficient binding region:433-481(IPR013083)	his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9NWM3	uniprotkb:Q62925	intact:EBI-5838167|uniprotkb:D3DTZ2|uniprotkb:Q9NWD0|ensembl:ENSP00000353373|ensembl:ENSP00000384712|ensembl:ENSP00000462717	intact:EBI-636664	psi-mi:cued1_human(display_long)|uniprotkb:CUEDC1(gene name)|psi-mi:CUEDC1(display_short)	psi-mi:m3k1_rat(display_long)|uniprotkb:MAPK/ERK kinase kinase 1(gene name synonym)|uniprotkb:Map3k1(gene name)|psi-mi:Map3k1(display_short)|uniprotkb:Mekk(gene name synonym)|uniprotkb:Mekk1(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9972839|imex:IM-22822-127	author-confidence:Z-score = 10.77	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001278954.1|refseq:XP_006721963.1|refseq:NP_001258804.1|ensembl:ENSP00000353373|ensembl:ENSP00000384712|ensembl:ENSP00000462717|ensembl:ENSG00000180891(gene)|ensembl:ENST00000360238(transcript)|ensembl:ENST00000407144(transcript)|ensembl:ENST00000577830(transcript)|go:"GO:0043130"(ubiquitin binding)|interpro:IPR003892(Ubiquitin system component Cue)|interpro:IPR009060(UBA-like)|interpro:IPR040192|interpro:IPR040195|rcsb pdb:2DHY	rgd:620966|refseq:NP_446339.1|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR007527(Zinc finger, SWIM-type)|go:"GO:0000165"(MAPK cascade)|interpro:IPR016024(Armadillo-type fold)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0002011"(morphogenesis of an epithelial sheet)|go:"GO:0003382"(epithelial cell morphogenesis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004706"(JUN kinase kinase kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007254"(JNK cascade)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008432"(JUN kinase binding)|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0016020"(membrane)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0031434"(mitogen-activated protein kinase kinase binding)|go:"GO:0031941"(filamentous actin)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0042060"(wound healing)|go:"GO:0043010"(camera-type eye development)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046625"(sphingolipid binding)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050434"(positive regulation of viral transcription)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0061029"(eyelid development in camera-type eye)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|reactome:R-RNO-166058|reactome:R-RNO-2871796|reactome:R-RNO-975138|reactome:R-RNO-975871|interpro:IPR011989(Armadillo-like helical)|mint:Q62925	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S3|resulting-ptm:Q9NWM3 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:WBb3Uq/e5Fmr5/qFgE0xlM5iJPQ9606	rogid:EwhjYjowkZIAt4UyPcZBUtf9uak10116	intact-crc:0C98E4948EE9A72D|rigid:9zLaaaDMuKUbn0Mvz7coLBAh2Lw	false	-	sufficient binding region:433-481(IPR013083)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9NWM3	uniprotkb:Q13404	intact:EBI-5838167|uniprotkb:D3DTZ2|uniprotkb:Q9NWD0|ensembl:ENSP00000353373|ensembl:ENSP00000384712|ensembl:ENSP00000462717	intact:EBI-1050671|uniprotkb:Q13403|uniprotkb:Q13532|uniprotkb:Q96H34|uniprotkb:Q9GZT0|uniprotkb:Q9GZW1|uniprotkb:Q9H4J3|uniprotkb:Q9H4J4|uniprotkb:Q9UKL1|uniprotkb:Q9UM48|uniprotkb:Q9UM49|uniprotkb:Q9UM50|uniprotkb:Q5TGE3|uniprotkb:E1P629|uniprotkb:Q5TGE0|ensembl:ENSP00000360739	psi-mi:cued1_human(display_long)|uniprotkb:CUEDC1(gene name)|psi-mi:CUEDC1(display_short)	psi-mi:ub2v1_human(display_long)|uniprotkb:CROC-1(gene name synonym)|uniprotkb:TRAF6-regulated IKK activator 1 beta Uev1A(gene name synonym)|uniprotkb:P/OKcl.19(orf name)|uniprotkb:UBE2V1(gene name)|psi-mi:UBE2V1(display_short)|uniprotkb:CROC1(gene name synonym)|uniprotkb:UBE2V(gene name synonym)|uniprotkb:UEV1(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9972839|imex:IM-22822-127	author-confidence:Z-score = 10.77	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001278954.1|refseq:XP_006721963.1|refseq:NP_001258804.1|ensembl:ENSP00000353373|ensembl:ENSP00000384712|ensembl:ENSP00000462717|ensembl:ENSG00000180891(gene)|ensembl:ENST00000360238(transcript)|ensembl:ENST00000407144(transcript)|ensembl:ENST00000577830(transcript)|go:"GO:0043130"(ubiquitin binding)|interpro:IPR003892(Ubiquitin system component Cue)|interpro:IPR009060(UBA-like)|interpro:IPR040192|interpro:IPR040195|rcsb pdb:2DHY	refseq:NP_001027459.1|refseq:NP_068823.2|refseq:NP_071887.1|refseq:NP_954595.1|refseq:NP_954673.1|refseq:NP_001244322.1|refseq:NP_001244323.1|refseq:NP_001244325.1|ensembl:ENSG00000244687(gene)|ensembl:ENST00000371674(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006282"(regulation of DNA repair)|go:"GO:0006301"(postreplication repair)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0030154"(cell differentiation)|go:"GO:0031371"(ubiquitin conjugating enzyme complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035370"(UBC13-UEV1A complex)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070534"(protein K63-linked ubiquitination)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|rcsb pdb:2A4D|rcsb pdb:2C2V|rcsb pdb:2HLW|rcsb pdb:6D6I|reactome:R-HSA-168638|reactome:R-HSA-168927|reactome:R-HSA-202424|reactome:R-HSA-2871837|reactome:R-HSA-445989|reactome:R-HSA-450302|reactome:R-HSA-450321|reactome:R-HSA-5607764|reactome:R-HSA-9020702|reactome:R-HSA-937039|reactome:R-HSA-937041|reactome:R-HSA-9646399|reactome:R-HSA-975110|reactome:R-HSA-975144|reactome:R-HSA-983168|dip:DIP-41911N	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S3|resulting-ptm:Q9NWM3 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:WBb3Uq/e5Fmr5/qFgE0xlM5iJPQ9606	rogid:x95N7Dj2KIqu5gySX59xLmfthUg9606	intact-crc:0C98E4948EE9A72D|rigid:9zLaaaDMuKUbn0Mvz7coLBAh2Lw	false	-	his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9NWM3	uniprotkb:P22314	intact:EBI-5838167|uniprotkb:D3DTZ2|uniprotkb:Q9NWD0|ensembl:ENSP00000353373|ensembl:ENSP00000384712|ensembl:ENSP00000462717	intact:EBI-709688|uniprotkb:Q96E13|uniprotkb:Q5JRR8|ensembl:ENSP00000338413|ensembl:ENSP00000366568	psi-mi:cued1_human(display_long)|uniprotkb:CUEDC1(gene name)|psi-mi:CUEDC1(display_short)	psi-mi:uba1_human(display_long)|uniprotkb:Ubiquitin-activating enzyme E1(gene name synonym)|uniprotkb:Protein A1S9(gene name synonym)|uniprotkb:UBA1(gene name)|psi-mi:UBA1(display_short)|uniprotkb:A1S9T(gene name synonym)|uniprotkb:UBE1(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9972839|imex:IM-22822-127	author-confidence:Z-score = 10.77	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001278954.1|refseq:XP_006721963.1|refseq:NP_001258804.1|ensembl:ENSP00000353373|ensembl:ENSP00000384712|ensembl:ENSP00000462717|ensembl:ENSG00000180891(gene)|ensembl:ENST00000360238(transcript)|ensembl:ENST00000407144(transcript)|ensembl:ENST00000577830(transcript)|go:"GO:0043130"(ubiquitin binding)|interpro:IPR003892(Ubiquitin system component Cue)|interpro:IPR009060(UBA-like)|interpro:IPR040192|interpro:IPR040195|rcsb pdb:2DHY	refseq:NP_003325.2|refseq:NP_695012.1|refseq:XP_016885269.1|refseq:XP_016885270.1|dip:DIP-33686N|ensembl:ENSG00000130985(gene)|ensembl:ENST00000335972(transcript)|ensembl:ENST00000377351(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0004839"(ubiquitin activating enzyme activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0032446"(protein modification by small protein conjugation)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000011(Ubiquitin-activating enzyme, E1)|interpro:IPR000594(UBA/THIF-type NAD/FAD binding fold)|interpro:IPR018074|interpro:IPR018075|interpro:IPR018965|interpro:IPR019572|interpro:IPR032418|interpro:IPR032420|interpro:IPR033127|interpro:IPR035985|interpro:IPR038252|interpro:IPR042063|interpro:IPR042302|interpro:IPR042449|mint:P22314|rcsb pdb:4P22|rcsb pdb:6DC6|reactome:R-HSA-8866652|reactome:R-HSA-983168	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S3|resulting-ptm:Q9NWM3 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:WBb3Uq/e5Fmr5/qFgE0xlM5iJPQ9606	rogid:q+vEeA0XLST0Zz173bmEt0dNbDE9606	intact-crc:0C98E4948EE9A72D|rigid:9zLaaaDMuKUbn0Mvz7coLBAh2Lw	false	-	his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9NWM3	uniprotkb:P61088	intact:EBI-5838167|uniprotkb:D3DTZ2|uniprotkb:Q9NWD0|ensembl:ENSP00000353373|ensembl:ENSP00000384712|ensembl:ENSP00000462717	intact:EBI-1052908|uniprotkb:Q16781|uniprotkb:Q53Y81|ensembl:ENSP00000316176	psi-mi:cued1_human(display_long)|uniprotkb:CUEDC1(gene name)|psi-mi:CUEDC1(display_short)	psi-mi:ube2n_human(display_long)|uniprotkb:Ubiquitin-protein ligase N(gene name synonym)|uniprotkb:Ubiquitin carrier protein N(gene name synonym)|uniprotkb:Ubc13(gene name synonym)|uniprotkb:Bendless-like ubiquitin-conjugating enzyme(gene name synonym)|uniprotkb:UBE2N(gene name)|psi-mi:UBE2N(display_short)|uniprotkb:BLU(gene name synonym)|uniprotkb:UbcH13(gene name synonym)|uniprotkb:E2 ubiquitin-conjugating enzyme N(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9972839|imex:IM-22822-127	author-confidence:Z-score = 10.77	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001278954.1|refseq:XP_006721963.1|refseq:NP_001258804.1|ensembl:ENSP00000353373|ensembl:ENSP00000384712|ensembl:ENSP00000462717|ensembl:ENSG00000180891(gene)|ensembl:ENST00000360238(transcript)|ensembl:ENST00000407144(transcript)|ensembl:ENST00000577830(transcript)|go:"GO:0043130"(ubiquitin binding)|interpro:IPR003892(Ubiquitin system component Cue)|interpro:IPR009060(UBA-like)|interpro:IPR040192|interpro:IPR040195|rcsb pdb:2DHY	refseq:NP_003339.1|dip:DIP-29829N|ensembl:ENSG00000177889(gene)|ensembl:ENST00000318066(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000729"(DNA double-strand break processing)|go:"GO:0001650"(fibrillar center)|go:"GO:0003723"(RNA binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006282"(regulation of DNA repair)|go:"GO:0006301"(postreplication repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016574"(histone ubiquitination)|go:"GO:0031058"(positive regulation of histone modification)|go:"GO:0031372"(UBC13-MMS2 complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033182"(regulation of histone ubiquitination)|go:"GO:0035370"(UBC13-UEV1A complex)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0061631"(ubiquitin conjugating enzyme activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070534"(protein K63-linked ubiquitination)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|interpro:IPR023313|rcsb pdb:1J7D|rcsb pdb:2C2V|rcsb pdb:3HCT|rcsb pdb:3HCU|rcsb pdb:3VON|rcsb pdb:3W31|rcsb pdb:4DHI|rcsb pdb:4DHJ|rcsb pdb:4DHZ|rcsb pdb:4IP3|rcsb pdb:4NR3|rcsb pdb:4NRG|rcsb pdb:4NRI|rcsb pdb:4ONL|rcsb pdb:4ONM|rcsb pdb:4ONN|rcsb pdb:4ORH|rcsb pdb:4TKP|rcsb pdb:4WHV|rcsb pdb:5AIT|rcsb pdb:5AIU|rcsb pdb:5EYA|rcsb pdb:5H7S|rcsb pdb:5VNZ|rcsb pdb:5VO0|rcsb pdb:5YWR|rcsb pdb:6D6I|rcsb pdb:6JKY|rcsb pdb:6KFP|rcsb pdb:6KG6|rcsb pdb:6KL4|rcsb pdb:6LP2|rcsb pdb:6P5B|rcsb pdb:6S53|reactome:R-HSA-168927|reactome:R-HSA-202424|reactome:R-HSA-2871837|reactome:R-HSA-445989|reactome:R-HSA-450302|reactome:R-HSA-450321|reactome:R-HSA-5607764|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-5696395|reactome:R-HSA-69473|reactome:R-HSA-8866654|reactome:R-HSA-9020702|reactome:R-HSA-937039|reactome:R-HSA-937041|reactome:R-HSA-9646399|reactome:R-HSA-975110|reactome:R-HSA-975144|reactome:R-HSA-983168|rcsb pdb:6ULH|rcsb pdb:6UMP|rcsb pdb:6UMS|rcsb pdb:7BBD|rcsb pdb:7BBF|rcsb pdb:7BXG|reactome:R-HSA-1169408|reactome:R-HSA-168638	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S3|resulting-ptm:Q9NWM3 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:WBb3Uq/e5Fmr5/qFgE0xlM5iJPQ9606	rogid:dqdszHlq5FLPHC6UWX6uvkC6Yz89606	intact-crc:0C98E4948EE9A72D|rigid:9zLaaaDMuKUbn0Mvz7coLBAh2Lw	false	-	his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9P2X3	uniprotkb:Q62925	intact:EBI-2857352|uniprotkb:A8MXG0|uniprotkb:Q49AM0|uniprotkb:Q9H2X4|ensembl:ENSP00000284202	intact:EBI-636664	psi-mi:impct_human(display_long)|uniprotkb:IMPACT(gene name)|psi-mi:IMPACT(display_short)|uniprotkb:Imprinted and ancient gene protein homolog(gene name synonym)	psi-mi:m3k1_rat(display_long)|uniprotkb:MAPK/ERK kinase kinase 1(gene name synonym)|uniprotkb:Map3k1(gene name)|psi-mi:Map3k1(display_short)|uniprotkb:Mekk(gene name synonym)|uniprotkb:Mekk1(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9972889|imex:IM-22822-129	author-confidence:Z-score = 7.65	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_060909.1|ensembl:ENSG00000154059(gene)|ensembl:ENST00000284202(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0003779"(actin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005844"(polysome)|go:"GO:0006446"(regulation of translational initiation)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0031953"(negative regulation of protein autophosphorylation)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0043022"(ribosome binding)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0071264"(positive regulation of translational initiation in response to starvation)|go:"GO:0071468"(cellular response to acidic pH)|go:"GO:0071494"(cellular response to UV-C)|go:"GO:0072755"(cellular response to benomyl)|go:"GO:0097201"(negative regulation of transcription from RNA polymerase II promoter in response to stress)|go:"GO:0140469"(GCN2-mediated signaling)|go:"GO:1990138"(neuron projection extension)|go:"GO:1990253"(cellular response to leucine starvation)|interpro:IPR001498(Protein of unknown function UPF0029, N-terminal)|interpro:IPR006575(RWD)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|interpro:IPR020568|interpro:IPR020569|interpro:IPR023582|interpro:IPR036956|reactome:R-HSA-9633012	rgd:620966|refseq:NP_446339.1|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR007527(Zinc finger, SWIM-type)|go:"GO:0000165"(MAPK cascade)|interpro:IPR016024(Armadillo-type fold)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0002011"(morphogenesis of an epithelial sheet)|go:"GO:0003382"(epithelial cell morphogenesis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004706"(JUN kinase kinase kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007254"(JNK cascade)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008432"(JUN kinase binding)|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0016020"(membrane)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0031434"(mitogen-activated protein kinase kinase binding)|go:"GO:0031941"(filamentous actin)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0042060"(wound healing)|go:"GO:0043010"(camera-type eye development)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046625"(sphingolipid binding)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050434"(positive regulation of viral transcription)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0061029"(eyelid development in camera-type eye)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|reactome:R-RNO-166058|reactome:R-RNO-2871796|reactome:R-RNO-975138|reactome:R-RNO-975871|interpro:IPR011989(Armadillo-like helical)|mint:Q62925	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S3|resulting-ptm:Q9P2X3 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:8TKZjuF5JkplyjE2D+6HlvygE4U9606	rogid:EwhjYjowkZIAt4UyPcZBUtf9uak10116	intact-crc:9B233A1FD36499F0|rigid:32li1ICM40VipSuKydBMi+UwduQ	false	-	sufficient binding region:433-481(IPR013083)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9P2X3	uniprotkb:Q13404	intact:EBI-2857352|uniprotkb:A8MXG0|uniprotkb:Q49AM0|uniprotkb:Q9H2X4|ensembl:ENSP00000284202	intact:EBI-1050671|uniprotkb:Q13403|uniprotkb:Q13532|uniprotkb:Q96H34|uniprotkb:Q9GZT0|uniprotkb:Q9GZW1|uniprotkb:Q9H4J3|uniprotkb:Q9H4J4|uniprotkb:Q9UKL1|uniprotkb:Q9UM48|uniprotkb:Q9UM49|uniprotkb:Q9UM50|uniprotkb:Q5TGE3|uniprotkb:E1P629|uniprotkb:Q5TGE0|ensembl:ENSP00000360739	psi-mi:impct_human(display_long)|uniprotkb:IMPACT(gene name)|psi-mi:IMPACT(display_short)|uniprotkb:Imprinted and ancient gene protein homolog(gene name synonym)	psi-mi:ub2v1_human(display_long)|uniprotkb:CROC-1(gene name synonym)|uniprotkb:TRAF6-regulated IKK activator 1 beta Uev1A(gene name synonym)|uniprotkb:P/OKcl.19(orf name)|uniprotkb:UBE2V1(gene name)|psi-mi:UBE2V1(display_short)|uniprotkb:CROC1(gene name synonym)|uniprotkb:UBE2V(gene name synonym)|uniprotkb:UEV1(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9972889|imex:IM-22822-129	author-confidence:Z-score = 7.65	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_060909.1|ensembl:ENSG00000154059(gene)|ensembl:ENST00000284202(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0003779"(actin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005844"(polysome)|go:"GO:0006446"(regulation of translational initiation)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0031953"(negative regulation of protein autophosphorylation)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0043022"(ribosome binding)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0071264"(positive regulation of translational initiation in response to starvation)|go:"GO:0071468"(cellular response to acidic pH)|go:"GO:0071494"(cellular response to UV-C)|go:"GO:0072755"(cellular response to benomyl)|go:"GO:0097201"(negative regulation of transcription from RNA polymerase II promoter in response to stress)|go:"GO:0140469"(GCN2-mediated signaling)|go:"GO:1990138"(neuron projection extension)|go:"GO:1990253"(cellular response to leucine starvation)|interpro:IPR001498(Protein of unknown function UPF0029, N-terminal)|interpro:IPR006575(RWD)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|interpro:IPR020568|interpro:IPR020569|interpro:IPR023582|interpro:IPR036956|reactome:R-HSA-9633012	refseq:NP_001027459.1|refseq:NP_068823.2|refseq:NP_071887.1|refseq:NP_954595.1|refseq:NP_954673.1|refseq:NP_001244322.1|refseq:NP_001244323.1|refseq:NP_001244325.1|ensembl:ENSG00000244687(gene)|ensembl:ENST00000371674(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006282"(regulation of DNA repair)|go:"GO:0006301"(postreplication repair)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0030154"(cell differentiation)|go:"GO:0031371"(ubiquitin conjugating enzyme complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035370"(UBC13-UEV1A complex)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070534"(protein K63-linked ubiquitination)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|rcsb pdb:2A4D|rcsb pdb:2C2V|rcsb pdb:2HLW|rcsb pdb:6D6I|reactome:R-HSA-168638|reactome:R-HSA-168927|reactome:R-HSA-202424|reactome:R-HSA-2871837|reactome:R-HSA-445989|reactome:R-HSA-450302|reactome:R-HSA-450321|reactome:R-HSA-5607764|reactome:R-HSA-9020702|reactome:R-HSA-937039|reactome:R-HSA-937041|reactome:R-HSA-9646399|reactome:R-HSA-975110|reactome:R-HSA-975144|reactome:R-HSA-983168|dip:DIP-41911N	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S3|resulting-ptm:Q9P2X3 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:8TKZjuF5JkplyjE2D+6HlvygE4U9606	rogid:x95N7Dj2KIqu5gySX59xLmfthUg9606	intact-crc:9B233A1FD36499F0|rigid:32li1ICM40VipSuKydBMi+UwduQ	false	-	his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9P2X3	uniprotkb:P22314	intact:EBI-2857352|uniprotkb:A8MXG0|uniprotkb:Q49AM0|uniprotkb:Q9H2X4|ensembl:ENSP00000284202	intact:EBI-709688|uniprotkb:Q96E13|uniprotkb:Q5JRR8|ensembl:ENSP00000338413|ensembl:ENSP00000366568	psi-mi:impct_human(display_long)|uniprotkb:IMPACT(gene name)|psi-mi:IMPACT(display_short)|uniprotkb:Imprinted and ancient gene protein homolog(gene name synonym)	psi-mi:uba1_human(display_long)|uniprotkb:Ubiquitin-activating enzyme E1(gene name synonym)|uniprotkb:Protein A1S9(gene name synonym)|uniprotkb:UBA1(gene name)|psi-mi:UBA1(display_short)|uniprotkb:A1S9T(gene name synonym)|uniprotkb:UBE1(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9972889|imex:IM-22822-129	author-confidence:Z-score = 7.65	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_060909.1|ensembl:ENSG00000154059(gene)|ensembl:ENST00000284202(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0003779"(actin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005844"(polysome)|go:"GO:0006446"(regulation of translational initiation)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0031953"(negative regulation of protein autophosphorylation)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0043022"(ribosome binding)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0071264"(positive regulation of translational initiation in response to starvation)|go:"GO:0071468"(cellular response to acidic pH)|go:"GO:0071494"(cellular response to UV-C)|go:"GO:0072755"(cellular response to benomyl)|go:"GO:0097201"(negative regulation of transcription from RNA polymerase II promoter in response to stress)|go:"GO:0140469"(GCN2-mediated signaling)|go:"GO:1990138"(neuron projection extension)|go:"GO:1990253"(cellular response to leucine starvation)|interpro:IPR001498(Protein of unknown function UPF0029, N-terminal)|interpro:IPR006575(RWD)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|interpro:IPR020568|interpro:IPR020569|interpro:IPR023582|interpro:IPR036956|reactome:R-HSA-9633012	refseq:NP_003325.2|refseq:NP_695012.1|refseq:XP_016885269.1|refseq:XP_016885270.1|dip:DIP-33686N|ensembl:ENSG00000130985(gene)|ensembl:ENST00000335972(transcript)|ensembl:ENST00000377351(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0004839"(ubiquitin activating enzyme activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0032446"(protein modification by small protein conjugation)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000011(Ubiquitin-activating enzyme, E1)|interpro:IPR000594(UBA/THIF-type NAD/FAD binding fold)|interpro:IPR018074|interpro:IPR018075|interpro:IPR018965|interpro:IPR019572|interpro:IPR032418|interpro:IPR032420|interpro:IPR033127|interpro:IPR035985|interpro:IPR038252|interpro:IPR042063|interpro:IPR042302|interpro:IPR042449|mint:P22314|rcsb pdb:4P22|rcsb pdb:6DC6|reactome:R-HSA-8866652|reactome:R-HSA-983168	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S3|resulting-ptm:Q9P2X3 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:8TKZjuF5JkplyjE2D+6HlvygE4U9606	rogid:q+vEeA0XLST0Zz173bmEt0dNbDE9606	intact-crc:9B233A1FD36499F0|rigid:32li1ICM40VipSuKydBMi+UwduQ	false	-	his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9P2X3	uniprotkb:P61088	intact:EBI-2857352|uniprotkb:A8MXG0|uniprotkb:Q49AM0|uniprotkb:Q9H2X4|ensembl:ENSP00000284202	intact:EBI-1052908|uniprotkb:Q16781|uniprotkb:Q53Y81|ensembl:ENSP00000316176	psi-mi:impct_human(display_long)|uniprotkb:IMPACT(gene name)|psi-mi:IMPACT(display_short)|uniprotkb:Imprinted and ancient gene protein homolog(gene name synonym)	psi-mi:ube2n_human(display_long)|uniprotkb:Ubiquitin-protein ligase N(gene name synonym)|uniprotkb:Ubiquitin carrier protein N(gene name synonym)|uniprotkb:Ubc13(gene name synonym)|uniprotkb:Bendless-like ubiquitin-conjugating enzyme(gene name synonym)|uniprotkb:UBE2N(gene name)|psi-mi:UBE2N(display_short)|uniprotkb:BLU(gene name synonym)|uniprotkb:UbcH13(gene name synonym)|uniprotkb:E2 ubiquitin-conjugating enzyme N(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9972889|imex:IM-22822-129	author-confidence:Z-score = 7.65	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_060909.1|ensembl:ENSG00000154059(gene)|ensembl:ENST00000284202(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0003779"(actin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005844"(polysome)|go:"GO:0006446"(regulation of translational initiation)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0031953"(negative regulation of protein autophosphorylation)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0043022"(ribosome binding)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0071264"(positive regulation of translational initiation in response to starvation)|go:"GO:0071468"(cellular response to acidic pH)|go:"GO:0071494"(cellular response to UV-C)|go:"GO:0072755"(cellular response to benomyl)|go:"GO:0097201"(negative regulation of transcription from RNA polymerase II promoter in response to stress)|go:"GO:0140469"(GCN2-mediated signaling)|go:"GO:1990138"(neuron projection extension)|go:"GO:1990253"(cellular response to leucine starvation)|interpro:IPR001498(Protein of unknown function UPF0029, N-terminal)|interpro:IPR006575(RWD)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|interpro:IPR020568|interpro:IPR020569|interpro:IPR023582|interpro:IPR036956|reactome:R-HSA-9633012	refseq:NP_003339.1|dip:DIP-29829N|ensembl:ENSG00000177889(gene)|ensembl:ENST00000318066(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000729"(DNA double-strand break processing)|go:"GO:0001650"(fibrillar center)|go:"GO:0003723"(RNA binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006282"(regulation of DNA repair)|go:"GO:0006301"(postreplication repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016574"(histone ubiquitination)|go:"GO:0031058"(positive regulation of histone modification)|go:"GO:0031372"(UBC13-MMS2 complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033182"(regulation of histone ubiquitination)|go:"GO:0035370"(UBC13-UEV1A complex)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0061631"(ubiquitin conjugating enzyme activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070534"(protein K63-linked ubiquitination)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|interpro:IPR023313|rcsb pdb:1J7D|rcsb pdb:2C2V|rcsb pdb:3HCT|rcsb pdb:3HCU|rcsb pdb:3VON|rcsb pdb:3W31|rcsb pdb:4DHI|rcsb pdb:4DHJ|rcsb pdb:4DHZ|rcsb pdb:4IP3|rcsb pdb:4NR3|rcsb pdb:4NRG|rcsb pdb:4NRI|rcsb pdb:4ONL|rcsb pdb:4ONM|rcsb pdb:4ONN|rcsb pdb:4ORH|rcsb pdb:4TKP|rcsb pdb:4WHV|rcsb pdb:5AIT|rcsb pdb:5AIU|rcsb pdb:5EYA|rcsb pdb:5H7S|rcsb pdb:5VNZ|rcsb pdb:5VO0|rcsb pdb:5YWR|rcsb pdb:6D6I|rcsb pdb:6JKY|rcsb pdb:6KFP|rcsb pdb:6KG6|rcsb pdb:6KL4|rcsb pdb:6LP2|rcsb pdb:6P5B|rcsb pdb:6S53|reactome:R-HSA-168927|reactome:R-HSA-202424|reactome:R-HSA-2871837|reactome:R-HSA-445989|reactome:R-HSA-450302|reactome:R-HSA-450321|reactome:R-HSA-5607764|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-5696395|reactome:R-HSA-69473|reactome:R-HSA-8866654|reactome:R-HSA-9020702|reactome:R-HSA-937039|reactome:R-HSA-937041|reactome:R-HSA-9646399|reactome:R-HSA-975110|reactome:R-HSA-975144|reactome:R-HSA-983168|rcsb pdb:6ULH|rcsb pdb:6UMP|rcsb pdb:6UMS|rcsb pdb:7BBD|rcsb pdb:7BBF|rcsb pdb:7BXG|reactome:R-HSA-1169408|reactome:R-HSA-168638	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S3|resulting-ptm:Q9P2X3 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:8TKZjuF5JkplyjE2D+6HlvygE4U9606	rogid:dqdszHlq5FLPHC6UWX6uvkC6Yz89606	intact-crc:9B233A1FD36499F0|rigid:32li1ICM40VipSuKydBMi+UwduQ	false	-	his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q62925	uniprotkb:Q13404	intact:EBI-636664	intact:EBI-1050671|uniprotkb:Q13403|uniprotkb:Q13532|uniprotkb:Q96H34|uniprotkb:Q9GZT0|uniprotkb:Q9GZW1|uniprotkb:Q9H4J3|uniprotkb:Q9H4J4|uniprotkb:Q9UKL1|uniprotkb:Q9UM48|uniprotkb:Q9UM49|uniprotkb:Q9UM50|uniprotkb:Q5TGE3|uniprotkb:E1P629|uniprotkb:Q5TGE0|ensembl:ENSP00000360739	psi-mi:m3k1_rat(display_long)|uniprotkb:MAPK/ERK kinase kinase 1(gene name synonym)|uniprotkb:Map3k1(gene name)|psi-mi:Map3k1(display_short)|uniprotkb:Mekk(gene name synonym)|uniprotkb:Mekk1(gene name synonym)	psi-mi:ub2v1_human(display_long)|uniprotkb:CROC-1(gene name synonym)|uniprotkb:TRAF6-regulated IKK activator 1 beta Uev1A(gene name synonym)|uniprotkb:P/OKcl.19(orf name)|uniprotkb:UBE2V1(gene name)|psi-mi:UBE2V1(display_short)|uniprotkb:CROC1(gene name synonym)|uniprotkb:UBE2V(gene name synonym)|uniprotkb:UEV1(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9972864|imex:IM-22822-128	author-confidence:Z-score = 9.21	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:620966|refseq:NP_446339.1|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR007527(Zinc finger, SWIM-type)|go:"GO:0000165"(MAPK cascade)|interpro:IPR016024(Armadillo-type fold)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0002011"(morphogenesis of an epithelial sheet)|go:"GO:0003382"(epithelial cell morphogenesis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004706"(JUN kinase kinase kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007254"(JNK cascade)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008432"(JUN kinase binding)|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0016020"(membrane)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0031434"(mitogen-activated protein kinase kinase binding)|go:"GO:0031941"(filamentous actin)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0042060"(wound healing)|go:"GO:0043010"(camera-type eye development)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046625"(sphingolipid binding)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050434"(positive regulation of viral transcription)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0061029"(eyelid development in camera-type eye)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|reactome:R-RNO-166058|reactome:R-RNO-2871796|reactome:R-RNO-975138|reactome:R-RNO-975871|interpro:IPR011989(Armadillo-like helical)|mint:Q62925	refseq:NP_001027459.1|refseq:NP_068823.2|refseq:NP_071887.1|refseq:NP_954595.1|refseq:NP_954673.1|refseq:NP_001244322.1|refseq:NP_001244323.1|refseq:NP_001244325.1|ensembl:ENSG00000244687(gene)|ensembl:ENST00000371674(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006282"(regulation of DNA repair)|go:"GO:0006301"(postreplication repair)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0030154"(cell differentiation)|go:"GO:0031371"(ubiquitin conjugating enzyme complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035370"(UBC13-UEV1A complex)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070534"(protein K63-linked ubiquitination)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|rcsb pdb:2A4D|rcsb pdb:2C2V|rcsb pdb:2HLW|rcsb pdb:6D6I|reactome:R-HSA-168638|reactome:R-HSA-168927|reactome:R-HSA-202424|reactome:R-HSA-2871837|reactome:R-HSA-445989|reactome:R-HSA-450302|reactome:R-HSA-450321|reactome:R-HSA-5607764|reactome:R-HSA-9020702|reactome:R-HSA-937039|reactome:R-HSA-937041|reactome:R-HSA-9646399|reactome:R-HSA-975110|reactome:R-HSA-975144|reactome:R-HSA-983168|dip:DIP-41911N	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S3|resulting-ptm:Q9NZ09 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:EwhjYjowkZIAt4UyPcZBUtf9uak10116	rogid:x95N7Dj2KIqu5gySX59xLmfthUg9606	intact-crc:95D353EB81292547|rigid:m+OjAL8rsfTkUXslFP6wxbhuUck	false	sufficient binding region:433-481(IPR013083)	his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q62925	uniprotkb:P22314	intact:EBI-636664	intact:EBI-709688|uniprotkb:Q96E13|uniprotkb:Q5JRR8|ensembl:ENSP00000338413|ensembl:ENSP00000366568	psi-mi:m3k1_rat(display_long)|uniprotkb:MAPK/ERK kinase kinase 1(gene name synonym)|uniprotkb:Map3k1(gene name)|psi-mi:Map3k1(display_short)|uniprotkb:Mekk(gene name synonym)|uniprotkb:Mekk1(gene name synonym)	psi-mi:uba1_human(display_long)|uniprotkb:Ubiquitin-activating enzyme E1(gene name synonym)|uniprotkb:Protein A1S9(gene name synonym)|uniprotkb:UBA1(gene name)|psi-mi:UBA1(display_short)|uniprotkb:A1S9T(gene name synonym)|uniprotkb:UBE1(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9972864|imex:IM-22822-128	author-confidence:Z-score = 9.21	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:620966|refseq:NP_446339.1|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR007527(Zinc finger, SWIM-type)|go:"GO:0000165"(MAPK cascade)|interpro:IPR016024(Armadillo-type fold)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0002011"(morphogenesis of an epithelial sheet)|go:"GO:0003382"(epithelial cell morphogenesis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004706"(JUN kinase kinase kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007254"(JNK cascade)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008432"(JUN kinase binding)|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0016020"(membrane)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0031434"(mitogen-activated protein kinase kinase binding)|go:"GO:0031941"(filamentous actin)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0042060"(wound healing)|go:"GO:0043010"(camera-type eye development)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046625"(sphingolipid binding)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050434"(positive regulation of viral transcription)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0061029"(eyelid development in camera-type eye)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|reactome:R-RNO-166058|reactome:R-RNO-2871796|reactome:R-RNO-975138|reactome:R-RNO-975871|interpro:IPR011989(Armadillo-like helical)|mint:Q62925	refseq:NP_003325.2|refseq:NP_695012.1|refseq:XP_016885269.1|refseq:XP_016885270.1|dip:DIP-33686N|ensembl:ENSG00000130985(gene)|ensembl:ENST00000335972(transcript)|ensembl:ENST00000377351(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0004839"(ubiquitin activating enzyme activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0032446"(protein modification by small protein conjugation)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000011(Ubiquitin-activating enzyme, E1)|interpro:IPR000594(UBA/THIF-type NAD/FAD binding fold)|interpro:IPR018074|interpro:IPR018075|interpro:IPR018965|interpro:IPR019572|interpro:IPR032418|interpro:IPR032420|interpro:IPR033127|interpro:IPR035985|interpro:IPR038252|interpro:IPR042063|interpro:IPR042302|interpro:IPR042449|mint:P22314|rcsb pdb:4P22|rcsb pdb:6DC6|reactome:R-HSA-8866652|reactome:R-HSA-983168	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S3|resulting-ptm:Q9NZ09 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:EwhjYjowkZIAt4UyPcZBUtf9uak10116	rogid:q+vEeA0XLST0Zz173bmEt0dNbDE9606	intact-crc:95D353EB81292547|rigid:m+OjAL8rsfTkUXslFP6wxbhuUck	false	sufficient binding region:433-481(IPR013083)	his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q62925	uniprotkb:Q9NZ09	intact:EBI-636664	intact:EBI-9641159|uniprotkb:D3DRL7|uniprotkb:Q4V759|uniprotkb:Q6FI75|uniprotkb:F5GXE2|uniprotkb:Q8NCG6|uniprotkb:Q5T7B3|uniprotkb:Q8NCH9|uniprotkb:F5H0J8|uniprotkb:B7Z8N9|uniprotkb:B7Z348|uniprotkb:Q8NC52|uniprotkb:Q53FP7|intact:EBI-28988054|ensembl:ENSP00000297661|ensembl:ENSP00000352541	psi-mi:m3k1_rat(display_long)|uniprotkb:MAPK/ERK kinase kinase 1(gene name synonym)|uniprotkb:Map3k1(gene name)|psi-mi:Map3k1(display_short)|uniprotkb:Mekk(gene name synonym)|uniprotkb:Mekk1(gene name synonym)	psi-mi:ubap1_human(display_long)|uniprotkb:UBAP1(gene name)|psi-mi:UBAP1(display_short)|uniprotkb:Nasopharyngeal carcinoma-associated gene 20 protein(gene name synonym)|uniprotkb:NAG20(orf name)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9972864|imex:IM-22822-128	author-confidence:Z-score = 9.21	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:620966|refseq:NP_446339.1|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR007527(Zinc finger, SWIM-type)|go:"GO:0000165"(MAPK cascade)|interpro:IPR016024(Armadillo-type fold)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0002011"(morphogenesis of an epithelial sheet)|go:"GO:0003382"(epithelial cell morphogenesis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004706"(JUN kinase kinase kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007254"(JNK cascade)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008432"(JUN kinase binding)|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0016020"(membrane)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0031434"(mitogen-activated protein kinase kinase binding)|go:"GO:0031941"(filamentous actin)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0042060"(wound healing)|go:"GO:0043010"(camera-type eye development)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046625"(sphingolipid binding)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050434"(positive regulation of viral transcription)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0061029"(eyelid development in camera-type eye)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|reactome:R-RNO-166058|reactome:R-RNO-2871796|reactome:R-RNO-975138|reactome:R-RNO-975871|interpro:IPR011989(Armadillo-like helical)|mint:Q62925	refseq:XP_011516201.1|ensembl:ENSP00000297661|ensembl:ENSP00000352541|ensembl:ENST00000379186|ensembl:ENSP00000368484|ensembl:ENST00000625521|ensembl:ENSP00000486574|refseq:NP_001164672.1|refseq:NP_001164673.1|refseq:NP_001164674.1|refseq:NP_001164675.1|refseq:NP_057609.2|refseq:XP_006716842.1|refseq:XP_016870290.1|dip:DIP-47291N|ensembl:ENSG00000165006(gene)|ensembl:ENST00000297661(transcript)|ensembl:ENST00000359544(transcript)|go:"GO:0000813"(ESCRT I complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0010008"(endosome membrane)|go:"GO:0015031"(protein transport)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043162"(ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway)|go:"GO:0043231"(intracellular membrane-bounded organelle)|interpro:IPR009060(UBA-like)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR023340|interpro:IPR038870|interpro:IPR042575|mint:Q9NZ09|rcsb pdb:1WGN|rcsb pdb:4AE4|rcsb pdb:5LM1|reactome:R-HSA-162588|reactome:R-HSA-174490|reactome:R-HSA-917729|reactome:R-HSA-9610379|reactome:R-HSA-9615710	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S3|resulting-ptm:Q9NZ09 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:EwhjYjowkZIAt4UyPcZBUtf9uak10116	rogid:Tsri0+z1BiAaBSf5ZKeTJFhaDeI9606	intact-crc:95D353EB81292547|rigid:m+OjAL8rsfTkUXslFP6wxbhuUck	false	sufficient binding region:433-481(IPR013083)	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q62925	uniprotkb:P61088	intact:EBI-636664	intact:EBI-1052908|uniprotkb:Q16781|uniprotkb:Q53Y81|ensembl:ENSP00000316176	psi-mi:m3k1_rat(display_long)|uniprotkb:MAPK/ERK kinase kinase 1(gene name synonym)|uniprotkb:Map3k1(gene name)|psi-mi:Map3k1(display_short)|uniprotkb:Mekk(gene name synonym)|uniprotkb:Mekk1(gene name synonym)	psi-mi:ube2n_human(display_long)|uniprotkb:Ubiquitin-protein ligase N(gene name synonym)|uniprotkb:Ubiquitin carrier protein N(gene name synonym)|uniprotkb:Ubc13(gene name synonym)|uniprotkb:Bendless-like ubiquitin-conjugating enzyme(gene name synonym)|uniprotkb:UBE2N(gene name)|psi-mi:UBE2N(display_short)|uniprotkb:BLU(gene name synonym)|uniprotkb:UbcH13(gene name synonym)|uniprotkb:E2 ubiquitin-conjugating enzyme N(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9972864|imex:IM-22822-128	author-confidence:Z-score = 9.21	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:620966|refseq:NP_446339.1|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR007527(Zinc finger, SWIM-type)|go:"GO:0000165"(MAPK cascade)|interpro:IPR016024(Armadillo-type fold)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0002011"(morphogenesis of an epithelial sheet)|go:"GO:0003382"(epithelial cell morphogenesis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004706"(JUN kinase kinase kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007254"(JNK cascade)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008432"(JUN kinase binding)|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0016020"(membrane)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0031434"(mitogen-activated protein kinase kinase binding)|go:"GO:0031941"(filamentous actin)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0042060"(wound healing)|go:"GO:0043010"(camera-type eye development)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046625"(sphingolipid binding)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050434"(positive regulation of viral transcription)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0061029"(eyelid development in camera-type eye)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|reactome:R-RNO-166058|reactome:R-RNO-2871796|reactome:R-RNO-975138|reactome:R-RNO-975871|interpro:IPR011989(Armadillo-like helical)|mint:Q62925	refseq:NP_003339.1|dip:DIP-29829N|ensembl:ENSG00000177889(gene)|ensembl:ENST00000318066(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000729"(DNA double-strand break processing)|go:"GO:0001650"(fibrillar center)|go:"GO:0003723"(RNA binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006282"(regulation of DNA repair)|go:"GO:0006301"(postreplication repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016574"(histone ubiquitination)|go:"GO:0031058"(positive regulation of histone modification)|go:"GO:0031372"(UBC13-MMS2 complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033182"(regulation of histone ubiquitination)|go:"GO:0035370"(UBC13-UEV1A complex)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0061631"(ubiquitin conjugating enzyme activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070534"(protein K63-linked ubiquitination)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|interpro:IPR023313|rcsb pdb:1J7D|rcsb pdb:2C2V|rcsb pdb:3HCT|rcsb pdb:3HCU|rcsb pdb:3VON|rcsb pdb:3W31|rcsb pdb:4DHI|rcsb pdb:4DHJ|rcsb pdb:4DHZ|rcsb pdb:4IP3|rcsb pdb:4NR3|rcsb pdb:4NRG|rcsb pdb:4NRI|rcsb pdb:4ONL|rcsb pdb:4ONM|rcsb pdb:4ONN|rcsb pdb:4ORH|rcsb pdb:4TKP|rcsb pdb:4WHV|rcsb pdb:5AIT|rcsb pdb:5AIU|rcsb pdb:5EYA|rcsb pdb:5H7S|rcsb pdb:5VNZ|rcsb pdb:5VO0|rcsb pdb:5YWR|rcsb pdb:6D6I|rcsb pdb:6JKY|rcsb pdb:6KFP|rcsb pdb:6KG6|rcsb pdb:6KL4|rcsb pdb:6LP2|rcsb pdb:6P5B|rcsb pdb:6S53|reactome:R-HSA-168927|reactome:R-HSA-202424|reactome:R-HSA-2871837|reactome:R-HSA-445989|reactome:R-HSA-450302|reactome:R-HSA-450321|reactome:R-HSA-5607764|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-5696395|reactome:R-HSA-69473|reactome:R-HSA-8866654|reactome:R-HSA-9020702|reactome:R-HSA-937039|reactome:R-HSA-937041|reactome:R-HSA-9646399|reactome:R-HSA-975110|reactome:R-HSA-975144|reactome:R-HSA-983168|rcsb pdb:6ULH|rcsb pdb:6UMP|rcsb pdb:6UMS|rcsb pdb:7BBD|rcsb pdb:7BBF|rcsb pdb:7BXG|reactome:R-HSA-1169408|reactome:R-HSA-168638	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S3|resulting-ptm:Q9NZ09 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:EwhjYjowkZIAt4UyPcZBUtf9uak10116	rogid:dqdszHlq5FLPHC6UWX6uvkC6Yz89606	intact-crc:95D353EB81292547|rigid:m+OjAL8rsfTkUXslFP6wxbhuUck	false	sufficient binding region:433-481(IPR013083)	his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9UBZ4	uniprotkb:Q62925	intact:EBI-742588|uniprotkb:Q9Y5X7|ensembl:ENSP00000364126	intact:EBI-636664	psi-mi:apex2_human(display_long)|uniprotkb:Apurinic-apyrimidinic endonuclease 2(gene name synonym)|uniprotkb:APEX nuclease 2(gene name synonym)|uniprotkb:APEX nuclease-like 2(gene name synonym)|uniprotkb:AP endonuclease XTH2(gene name synonym)|uniprotkb:APEX2(gene name)|psi-mi:APEX2(display_short)|uniprotkb:APE2(gene name synonym)|uniprotkb:APEXL2(gene name synonym)|uniprotkb:XTH2(gene name synonym)	psi-mi:m3k1_rat(display_long)|uniprotkb:MAPK/ERK kinase kinase 1(gene name synonym)|uniprotkb:Map3k1(gene name)|psi-mi:Map3k1(display_short)|uniprotkb:Mekk(gene name synonym)|uniprotkb:Mekk1(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9972914|imex:IM-22822-130	author-confidence:Z-score = 3.85	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_055296.2|go:"GO:0004519"(endonuclease activity)|go:"GO:0004528"(phosphodiesterase I activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0006284"(base-excision repair)|go:"GO:0006310"(DNA recombination)|go:"GO:0007049"(cell cycle)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008311"(double-stranded DNA 3'-5' exodeoxyribonuclease activity)|go:"GO:0043231"(intracellular membrane-bounded organelle)|interpro:IPR004808(Exodeoxyribonuclease III xth)|interpro:IPR005135(Endonuclease/exonuclease/phosphatase)|interpro:IPR010666(Zinc finger, GRF-type)|interpro:IPR020847|interpro:IPR036691|ensembl:ENSG00000169188(gene)|ensembl:ENST00000374987(transcript)|go:"GO:0001650"(fibrillar center)|go:"GO:0003677"(DNA binding)|go:"GO:0003906"("DNA-(apurinic or apyrimidinic site) endonuclease activity")	rgd:620966|refseq:NP_446339.1|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR007527(Zinc finger, SWIM-type)|go:"GO:0000165"(MAPK cascade)|interpro:IPR016024(Armadillo-type fold)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0002011"(morphogenesis of an epithelial sheet)|go:"GO:0003382"(epithelial cell morphogenesis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004706"(JUN kinase kinase kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007254"(JNK cascade)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008432"(JUN kinase binding)|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0016020"(membrane)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0031434"(mitogen-activated protein kinase kinase binding)|go:"GO:0031941"(filamentous actin)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0042060"(wound healing)|go:"GO:0043010"(camera-type eye development)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046625"(sphingolipid binding)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050434"(positive regulation of viral transcription)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0061029"(eyelid development in camera-type eye)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|reactome:R-RNO-166058|reactome:R-RNO-2871796|reactome:R-RNO-975138|reactome:R-RNO-975871|interpro:IPR011989(Armadillo-like helical)|mint:Q62925	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S3|resulting-ptm:Q9UBZ4 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:QJEwQWbkLhf2cixDOWo024QN29M9606	rogid:EwhjYjowkZIAt4UyPcZBUtf9uak10116	intact-crc:5DE59F6524EFD813|rigid:AqKc14r9RC6TeMoh4hrUZvg6xXs	false	-	sufficient binding region:433-481(IPR013083)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9UBZ4	uniprotkb:Q13404	intact:EBI-742588|uniprotkb:Q9Y5X7|ensembl:ENSP00000364126	intact:EBI-1050671|uniprotkb:Q13403|uniprotkb:Q13532|uniprotkb:Q96H34|uniprotkb:Q9GZT0|uniprotkb:Q9GZW1|uniprotkb:Q9H4J3|uniprotkb:Q9H4J4|uniprotkb:Q9UKL1|uniprotkb:Q9UM48|uniprotkb:Q9UM49|uniprotkb:Q9UM50|uniprotkb:Q5TGE3|uniprotkb:E1P629|uniprotkb:Q5TGE0|ensembl:ENSP00000360739	psi-mi:apex2_human(display_long)|uniprotkb:Apurinic-apyrimidinic endonuclease 2(gene name synonym)|uniprotkb:APEX nuclease 2(gene name synonym)|uniprotkb:APEX nuclease-like 2(gene name synonym)|uniprotkb:AP endonuclease XTH2(gene name synonym)|uniprotkb:APEX2(gene name)|psi-mi:APEX2(display_short)|uniprotkb:APE2(gene name synonym)|uniprotkb:APEXL2(gene name synonym)|uniprotkb:XTH2(gene name synonym)	psi-mi:ub2v1_human(display_long)|uniprotkb:CROC-1(gene name synonym)|uniprotkb:TRAF6-regulated IKK activator 1 beta Uev1A(gene name synonym)|uniprotkb:P/OKcl.19(orf name)|uniprotkb:UBE2V1(gene name)|psi-mi:UBE2V1(display_short)|uniprotkb:CROC1(gene name synonym)|uniprotkb:UBE2V(gene name synonym)|uniprotkb:UEV1(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9972914|imex:IM-22822-130	author-confidence:Z-score = 3.85	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_055296.2|go:"GO:0004519"(endonuclease activity)|go:"GO:0004528"(phosphodiesterase I activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0006284"(base-excision repair)|go:"GO:0006310"(DNA recombination)|go:"GO:0007049"(cell cycle)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008311"(double-stranded DNA 3'-5' exodeoxyribonuclease activity)|go:"GO:0043231"(intracellular membrane-bounded organelle)|interpro:IPR004808(Exodeoxyribonuclease III xth)|interpro:IPR005135(Endonuclease/exonuclease/phosphatase)|interpro:IPR010666(Zinc finger, GRF-type)|interpro:IPR020847|interpro:IPR036691|ensembl:ENSG00000169188(gene)|ensembl:ENST00000374987(transcript)|go:"GO:0001650"(fibrillar center)|go:"GO:0003677"(DNA binding)|go:"GO:0003906"("DNA-(apurinic or apyrimidinic site) endonuclease activity")	refseq:NP_001027459.1|refseq:NP_068823.2|refseq:NP_071887.1|refseq:NP_954595.1|refseq:NP_954673.1|refseq:NP_001244322.1|refseq:NP_001244323.1|refseq:NP_001244325.1|ensembl:ENSG00000244687(gene)|ensembl:ENST00000371674(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006282"(regulation of DNA repair)|go:"GO:0006301"(postreplication repair)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0030154"(cell differentiation)|go:"GO:0031371"(ubiquitin conjugating enzyme complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035370"(UBC13-UEV1A complex)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070534"(protein K63-linked ubiquitination)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|rcsb pdb:2A4D|rcsb pdb:2C2V|rcsb pdb:2HLW|rcsb pdb:6D6I|reactome:R-HSA-168638|reactome:R-HSA-168927|reactome:R-HSA-202424|reactome:R-HSA-2871837|reactome:R-HSA-445989|reactome:R-HSA-450302|reactome:R-HSA-450321|reactome:R-HSA-5607764|reactome:R-HSA-9020702|reactome:R-HSA-937039|reactome:R-HSA-937041|reactome:R-HSA-9646399|reactome:R-HSA-975110|reactome:R-HSA-975144|reactome:R-HSA-983168|dip:DIP-41911N	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S3|resulting-ptm:Q9UBZ4 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:QJEwQWbkLhf2cixDOWo024QN29M9606	rogid:x95N7Dj2KIqu5gySX59xLmfthUg9606	intact-crc:5DE59F6524EFD813|rigid:AqKc14r9RC6TeMoh4hrUZvg6xXs	false	-	his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9UBZ4	uniprotkb:P22314	intact:EBI-742588|uniprotkb:Q9Y5X7|ensembl:ENSP00000364126	intact:EBI-709688|uniprotkb:Q96E13|uniprotkb:Q5JRR8|ensembl:ENSP00000338413|ensembl:ENSP00000366568	psi-mi:apex2_human(display_long)|uniprotkb:Apurinic-apyrimidinic endonuclease 2(gene name synonym)|uniprotkb:APEX nuclease 2(gene name synonym)|uniprotkb:APEX nuclease-like 2(gene name synonym)|uniprotkb:AP endonuclease XTH2(gene name synonym)|uniprotkb:APEX2(gene name)|psi-mi:APEX2(display_short)|uniprotkb:APE2(gene name synonym)|uniprotkb:APEXL2(gene name synonym)|uniprotkb:XTH2(gene name synonym)	psi-mi:uba1_human(display_long)|uniprotkb:Ubiquitin-activating enzyme E1(gene name synonym)|uniprotkb:Protein A1S9(gene name synonym)|uniprotkb:UBA1(gene name)|psi-mi:UBA1(display_short)|uniprotkb:A1S9T(gene name synonym)|uniprotkb:UBE1(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9972914|imex:IM-22822-130	author-confidence:Z-score = 3.85	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_055296.2|go:"GO:0004519"(endonuclease activity)|go:"GO:0004528"(phosphodiesterase I activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0006284"(base-excision repair)|go:"GO:0006310"(DNA recombination)|go:"GO:0007049"(cell cycle)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008311"(double-stranded DNA 3'-5' exodeoxyribonuclease activity)|go:"GO:0043231"(intracellular membrane-bounded organelle)|interpro:IPR004808(Exodeoxyribonuclease III xth)|interpro:IPR005135(Endonuclease/exonuclease/phosphatase)|interpro:IPR010666(Zinc finger, GRF-type)|interpro:IPR020847|interpro:IPR036691|ensembl:ENSG00000169188(gene)|ensembl:ENST00000374987(transcript)|go:"GO:0001650"(fibrillar center)|go:"GO:0003677"(DNA binding)|go:"GO:0003906"("DNA-(apurinic or apyrimidinic site) endonuclease activity")	refseq:NP_003325.2|refseq:NP_695012.1|refseq:XP_016885269.1|refseq:XP_016885270.1|dip:DIP-33686N|ensembl:ENSG00000130985(gene)|ensembl:ENST00000335972(transcript)|ensembl:ENST00000377351(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0004839"(ubiquitin activating enzyme activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0032446"(protein modification by small protein conjugation)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000011(Ubiquitin-activating enzyme, E1)|interpro:IPR000594(UBA/THIF-type NAD/FAD binding fold)|interpro:IPR018074|interpro:IPR018075|interpro:IPR018965|interpro:IPR019572|interpro:IPR032418|interpro:IPR032420|interpro:IPR033127|interpro:IPR035985|interpro:IPR038252|interpro:IPR042063|interpro:IPR042302|interpro:IPR042449|mint:P22314|rcsb pdb:4P22|rcsb pdb:6DC6|reactome:R-HSA-8866652|reactome:R-HSA-983168	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S3|resulting-ptm:Q9UBZ4 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:QJEwQWbkLhf2cixDOWo024QN29M9606	rogid:q+vEeA0XLST0Zz173bmEt0dNbDE9606	intact-crc:5DE59F6524EFD813|rigid:AqKc14r9RC6TeMoh4hrUZvg6xXs	false	-	his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9UBZ4	uniprotkb:P61088	intact:EBI-742588|uniprotkb:Q9Y5X7|ensembl:ENSP00000364126	intact:EBI-1052908|uniprotkb:Q16781|uniprotkb:Q53Y81|ensembl:ENSP00000316176	psi-mi:apex2_human(display_long)|uniprotkb:Apurinic-apyrimidinic endonuclease 2(gene name synonym)|uniprotkb:APEX nuclease 2(gene name synonym)|uniprotkb:APEX nuclease-like 2(gene name synonym)|uniprotkb:AP endonuclease XTH2(gene name synonym)|uniprotkb:APEX2(gene name)|psi-mi:APEX2(display_short)|uniprotkb:APE2(gene name synonym)|uniprotkb:APEXL2(gene name synonym)|uniprotkb:XTH2(gene name synonym)	psi-mi:ube2n_human(display_long)|uniprotkb:Ubiquitin-protein ligase N(gene name synonym)|uniprotkb:Ubiquitin carrier protein N(gene name synonym)|uniprotkb:Ubc13(gene name synonym)|uniprotkb:Bendless-like ubiquitin-conjugating enzyme(gene name synonym)|uniprotkb:UBE2N(gene name)|psi-mi:UBE2N(display_short)|uniprotkb:BLU(gene name synonym)|uniprotkb:UbcH13(gene name synonym)|uniprotkb:E2 ubiquitin-conjugating enzyme N(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9972914|imex:IM-22822-130	author-confidence:Z-score = 3.85	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_055296.2|go:"GO:0004519"(endonuclease activity)|go:"GO:0004528"(phosphodiesterase I activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0006284"(base-excision repair)|go:"GO:0006310"(DNA recombination)|go:"GO:0007049"(cell cycle)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008311"(double-stranded DNA 3'-5' exodeoxyribonuclease activity)|go:"GO:0043231"(intracellular membrane-bounded organelle)|interpro:IPR004808(Exodeoxyribonuclease III xth)|interpro:IPR005135(Endonuclease/exonuclease/phosphatase)|interpro:IPR010666(Zinc finger, GRF-type)|interpro:IPR020847|interpro:IPR036691|ensembl:ENSG00000169188(gene)|ensembl:ENST00000374987(transcript)|go:"GO:0001650"(fibrillar center)|go:"GO:0003677"(DNA binding)|go:"GO:0003906"("DNA-(apurinic or apyrimidinic site) endonuclease activity")	refseq:NP_003339.1|dip:DIP-29829N|ensembl:ENSG00000177889(gene)|ensembl:ENST00000318066(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000729"(DNA double-strand break processing)|go:"GO:0001650"(fibrillar center)|go:"GO:0003723"(RNA binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006282"(regulation of DNA repair)|go:"GO:0006301"(postreplication repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016574"(histone ubiquitination)|go:"GO:0031058"(positive regulation of histone modification)|go:"GO:0031372"(UBC13-MMS2 complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033182"(regulation of histone ubiquitination)|go:"GO:0035370"(UBC13-UEV1A complex)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0061631"(ubiquitin conjugating enzyme activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070534"(protein K63-linked ubiquitination)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|interpro:IPR023313|rcsb pdb:1J7D|rcsb pdb:2C2V|rcsb pdb:3HCT|rcsb pdb:3HCU|rcsb pdb:3VON|rcsb pdb:3W31|rcsb pdb:4DHI|rcsb pdb:4DHJ|rcsb pdb:4DHZ|rcsb pdb:4IP3|rcsb pdb:4NR3|rcsb pdb:4NRG|rcsb pdb:4NRI|rcsb pdb:4ONL|rcsb pdb:4ONM|rcsb pdb:4ONN|rcsb pdb:4ORH|rcsb pdb:4TKP|rcsb pdb:4WHV|rcsb pdb:5AIT|rcsb pdb:5AIU|rcsb pdb:5EYA|rcsb pdb:5H7S|rcsb pdb:5VNZ|rcsb pdb:5VO0|rcsb pdb:5YWR|rcsb pdb:6D6I|rcsb pdb:6JKY|rcsb pdb:6KFP|rcsb pdb:6KG6|rcsb pdb:6KL4|rcsb pdb:6LP2|rcsb pdb:6P5B|rcsb pdb:6S53|reactome:R-HSA-168927|reactome:R-HSA-202424|reactome:R-HSA-2871837|reactome:R-HSA-445989|reactome:R-HSA-450302|reactome:R-HSA-450321|reactome:R-HSA-5607764|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-5696395|reactome:R-HSA-69473|reactome:R-HSA-8866654|reactome:R-HSA-9020702|reactome:R-HSA-937039|reactome:R-HSA-937041|reactome:R-HSA-9646399|reactome:R-HSA-975110|reactome:R-HSA-975144|reactome:R-HSA-983168|rcsb pdb:6ULH|rcsb pdb:6UMP|rcsb pdb:6UMS|rcsb pdb:7BBD|rcsb pdb:7BBF|rcsb pdb:7BXG|reactome:R-HSA-1169408|reactome:R-HSA-168638	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S3|resulting-ptm:Q9UBZ4 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:QJEwQWbkLhf2cixDOWo024QN29M9606	rogid:dqdszHlq5FLPHC6UWX6uvkC6Yz89606	intact-crc:5DE59F6524EFD813|rigid:AqKc14r9RC6TeMoh4hrUZvg6xXs	false	-	his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9UKG1	uniprotkb:Q62925	intact:EBI-741243|intact:EBI-28979536|ensembl:ENSP00000288266|ensembl:ENSP00000498115|uniprotkb:Q9P2B9	intact:EBI-636664	psi-mi:dp13a_human(display_long)|uniprotkb:Adapter protein containing PH domain, PTB domain and leucine zipper motif 1(gene name synonym)|uniprotkb:APPL1(gene name)|psi-mi:APPL1(display_short)|uniprotkb:APPL(gene name synonym)|uniprotkb:DIP13A(gene name synonym)|uniprotkb:KIAA1428(gene name synonym)	psi-mi:m3k1_rat(display_long)|uniprotkb:MAPK/ERK kinase kinase 1(gene name synonym)|uniprotkb:Map3k1(gene name)|psi-mi:Map3k1(display_short)|uniprotkb:Mekk(gene name synonym)|uniprotkb:Mekk1(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9972964|imex:IM-22822-132	author-confidence:Z-score = 10.77	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000157500(gene)|ensembl:ENST00000288266(transcript)|ensembl:ENST00000650354(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0007049"(cell cycle)|go:"GO:0007165"(signal transduction)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010008"(endosome membrane)|go:"GO:0010762"(regulation of fibroblast migration)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0023052"(signaling)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032009"(early phagosome)|go:"GO:0033211"(adiponectin-activated signaling pathway)|go:"GO:0034143"(regulation of toll-like receptor 4 signaling pathway)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0035729"(cellular response to hepatocyte growth factor stimulus)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043422"(protein kinase B binding)|go:"GO:0044354"(macropinosome)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045088"(regulation of innate immune response)|go:"GO:0046324"(regulation of glucose import)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0048023"(positive regulation of melanin biosynthetic process)|go:"GO:0048487"(beta-tubulin binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097708"(intracellular vesicle)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|go:"GO:1903076"(regulation of protein localization to plasma membrane)|go:"GO:1905303"(positive regulation of macropinocytosis)|go:"GO:1905450"(negative regulation of Fc-gamma receptor signaling pathway involved in phagocytosis)|interpro:IPR027267|interpro:IPR037929|mint:Q9UKG1|rcsb pdb:2EJ8|rcsb pdb:2ELA|rcsb pdb:2ELB|rcsb pdb:2Q12|rcsb pdb:2Q13|rcsb pdb:2Z0N|rcsb pdb:2Z0O|rcsb pdb:5C5B|reactome:R-HSA-418889|go:"GO:2000045"(regulation of G1/S transition of mitotic cell cycle)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR011993(Pleckstrin homology-type)|refseq:NP_036228.1|ensembl:ENSP00000288266|ensembl:ENSP00000498115|dip:DIP-29322N	rgd:620966|refseq:NP_446339.1|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR007527(Zinc finger, SWIM-type)|go:"GO:0000165"(MAPK cascade)|interpro:IPR016024(Armadillo-type fold)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0002011"(morphogenesis of an epithelial sheet)|go:"GO:0003382"(epithelial cell morphogenesis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004706"(JUN kinase kinase kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007254"(JNK cascade)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008432"(JUN kinase binding)|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0016020"(membrane)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0031434"(mitogen-activated protein kinase kinase binding)|go:"GO:0031941"(filamentous actin)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0042060"(wound healing)|go:"GO:0043010"(camera-type eye development)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046625"(sphingolipid binding)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050434"(positive regulation of viral transcription)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0061029"(eyelid development in camera-type eye)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|reactome:R-RNO-166058|reactome:R-RNO-2871796|reactome:R-RNO-975138|reactome:R-RNO-975871|interpro:IPR011989(Armadillo-like helical)|mint:Q62925	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S3|resulting-ptm:Q9UKG1 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:v94zzPKDww+kZxRttd3FHIXIx/w9606	rogid:EwhjYjowkZIAt4UyPcZBUtf9uak10116	intact-crc:4DB97864629E704F|rigid:3ljoli2ZzCB8ReFigTZbfDCVYno	false	-	sufficient binding region:433-481(IPR013083)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9UKG1	uniprotkb:Q13404	intact:EBI-741243|intact:EBI-28979536|ensembl:ENSP00000288266|ensembl:ENSP00000498115|uniprotkb:Q9P2B9	intact:EBI-1050671|uniprotkb:Q13403|uniprotkb:Q13532|uniprotkb:Q96H34|uniprotkb:Q9GZT0|uniprotkb:Q9GZW1|uniprotkb:Q9H4J3|uniprotkb:Q9H4J4|uniprotkb:Q9UKL1|uniprotkb:Q9UM48|uniprotkb:Q9UM49|uniprotkb:Q9UM50|uniprotkb:Q5TGE3|uniprotkb:E1P629|uniprotkb:Q5TGE0|ensembl:ENSP00000360739	psi-mi:dp13a_human(display_long)|uniprotkb:Adapter protein containing PH domain, PTB domain and leucine zipper motif 1(gene name synonym)|uniprotkb:APPL1(gene name)|psi-mi:APPL1(display_short)|uniprotkb:APPL(gene name synonym)|uniprotkb:DIP13A(gene name synonym)|uniprotkb:KIAA1428(gene name synonym)	psi-mi:ub2v1_human(display_long)|uniprotkb:CROC-1(gene name synonym)|uniprotkb:TRAF6-regulated IKK activator 1 beta Uev1A(gene name synonym)|uniprotkb:P/OKcl.19(orf name)|uniprotkb:UBE2V1(gene name)|psi-mi:UBE2V1(display_short)|uniprotkb:CROC1(gene name synonym)|uniprotkb:UBE2V(gene name synonym)|uniprotkb:UEV1(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9972964|imex:IM-22822-132	author-confidence:Z-score = 10.77	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000157500(gene)|ensembl:ENST00000288266(transcript)|ensembl:ENST00000650354(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0007049"(cell cycle)|go:"GO:0007165"(signal transduction)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010008"(endosome membrane)|go:"GO:0010762"(regulation of fibroblast migration)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0023052"(signaling)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032009"(early phagosome)|go:"GO:0033211"(adiponectin-activated signaling pathway)|go:"GO:0034143"(regulation of toll-like receptor 4 signaling pathway)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0035729"(cellular response to hepatocyte growth factor stimulus)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043422"(protein kinase B binding)|go:"GO:0044354"(macropinosome)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045088"(regulation of innate immune response)|go:"GO:0046324"(regulation of glucose import)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0048023"(positive regulation of melanin biosynthetic process)|go:"GO:0048487"(beta-tubulin binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097708"(intracellular vesicle)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|go:"GO:1903076"(regulation of protein localization to plasma membrane)|go:"GO:1905303"(positive regulation of macropinocytosis)|go:"GO:1905450"(negative regulation of Fc-gamma receptor signaling pathway involved in phagocytosis)|interpro:IPR027267|interpro:IPR037929|mint:Q9UKG1|rcsb pdb:2EJ8|rcsb pdb:2ELA|rcsb pdb:2ELB|rcsb pdb:2Q12|rcsb pdb:2Q13|rcsb pdb:2Z0N|rcsb pdb:2Z0O|rcsb pdb:5C5B|reactome:R-HSA-418889|go:"GO:2000045"(regulation of G1/S transition of mitotic cell cycle)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR011993(Pleckstrin homology-type)|refseq:NP_036228.1|ensembl:ENSP00000288266|ensembl:ENSP00000498115|dip:DIP-29322N	refseq:NP_001027459.1|refseq:NP_068823.2|refseq:NP_071887.1|refseq:NP_954595.1|refseq:NP_954673.1|refseq:NP_001244322.1|refseq:NP_001244323.1|refseq:NP_001244325.1|ensembl:ENSG00000244687(gene)|ensembl:ENST00000371674(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006282"(regulation of DNA repair)|go:"GO:0006301"(postreplication repair)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0030154"(cell differentiation)|go:"GO:0031371"(ubiquitin conjugating enzyme complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035370"(UBC13-UEV1A complex)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070534"(protein K63-linked ubiquitination)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|rcsb pdb:2A4D|rcsb pdb:2C2V|rcsb pdb:2HLW|rcsb pdb:6D6I|reactome:R-HSA-168638|reactome:R-HSA-168927|reactome:R-HSA-202424|reactome:R-HSA-2871837|reactome:R-HSA-445989|reactome:R-HSA-450302|reactome:R-HSA-450321|reactome:R-HSA-5607764|reactome:R-HSA-9020702|reactome:R-HSA-937039|reactome:R-HSA-937041|reactome:R-HSA-9646399|reactome:R-HSA-975110|reactome:R-HSA-975144|reactome:R-HSA-983168|dip:DIP-41911N	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S3|resulting-ptm:Q9UKG1 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:v94zzPKDww+kZxRttd3FHIXIx/w9606	rogid:x95N7Dj2KIqu5gySX59xLmfthUg9606	intact-crc:4DB97864629E704F|rigid:3ljoli2ZzCB8ReFigTZbfDCVYno	false	-	his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9UKG1	uniprotkb:P22314	intact:EBI-741243|intact:EBI-28979536|ensembl:ENSP00000288266|ensembl:ENSP00000498115|uniprotkb:Q9P2B9	intact:EBI-709688|uniprotkb:Q96E13|uniprotkb:Q5JRR8|ensembl:ENSP00000338413|ensembl:ENSP00000366568	psi-mi:dp13a_human(display_long)|uniprotkb:Adapter protein containing PH domain, PTB domain and leucine zipper motif 1(gene name synonym)|uniprotkb:APPL1(gene name)|psi-mi:APPL1(display_short)|uniprotkb:APPL(gene name synonym)|uniprotkb:DIP13A(gene name synonym)|uniprotkb:KIAA1428(gene name synonym)	psi-mi:uba1_human(display_long)|uniprotkb:Ubiquitin-activating enzyme E1(gene name synonym)|uniprotkb:Protein A1S9(gene name synonym)|uniprotkb:UBA1(gene name)|psi-mi:UBA1(display_short)|uniprotkb:A1S9T(gene name synonym)|uniprotkb:UBE1(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9972964|imex:IM-22822-132	author-confidence:Z-score = 10.77	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000157500(gene)|ensembl:ENST00000288266(transcript)|ensembl:ENST00000650354(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0007049"(cell cycle)|go:"GO:0007165"(signal transduction)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010008"(endosome membrane)|go:"GO:0010762"(regulation of fibroblast migration)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0023052"(signaling)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032009"(early phagosome)|go:"GO:0033211"(adiponectin-activated signaling pathway)|go:"GO:0034143"(regulation of toll-like receptor 4 signaling pathway)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0035729"(cellular response to hepatocyte growth factor stimulus)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043422"(protein kinase B binding)|go:"GO:0044354"(macropinosome)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045088"(regulation of innate immune response)|go:"GO:0046324"(regulation of glucose import)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0048023"(positive regulation of melanin biosynthetic process)|go:"GO:0048487"(beta-tubulin binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097708"(intracellular vesicle)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|go:"GO:1903076"(regulation of protein localization to plasma membrane)|go:"GO:1905303"(positive regulation of macropinocytosis)|go:"GO:1905450"(negative regulation of Fc-gamma receptor signaling pathway involved in phagocytosis)|interpro:IPR027267|interpro:IPR037929|mint:Q9UKG1|rcsb pdb:2EJ8|rcsb pdb:2ELA|rcsb pdb:2ELB|rcsb pdb:2Q12|rcsb pdb:2Q13|rcsb pdb:2Z0N|rcsb pdb:2Z0O|rcsb pdb:5C5B|reactome:R-HSA-418889|go:"GO:2000045"(regulation of G1/S transition of mitotic cell cycle)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR011993(Pleckstrin homology-type)|refseq:NP_036228.1|ensembl:ENSP00000288266|ensembl:ENSP00000498115|dip:DIP-29322N	refseq:NP_003325.2|refseq:NP_695012.1|refseq:XP_016885269.1|refseq:XP_016885270.1|dip:DIP-33686N|ensembl:ENSG00000130985(gene)|ensembl:ENST00000335972(transcript)|ensembl:ENST00000377351(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0004839"(ubiquitin activating enzyme activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0032446"(protein modification by small protein conjugation)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000011(Ubiquitin-activating enzyme, E1)|interpro:IPR000594(UBA/THIF-type NAD/FAD binding fold)|interpro:IPR018074|interpro:IPR018075|interpro:IPR018965|interpro:IPR019572|interpro:IPR032418|interpro:IPR032420|interpro:IPR033127|interpro:IPR035985|interpro:IPR038252|interpro:IPR042063|interpro:IPR042302|interpro:IPR042449|mint:P22314|rcsb pdb:4P22|rcsb pdb:6DC6|reactome:R-HSA-8866652|reactome:R-HSA-983168	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S3|resulting-ptm:Q9UKG1 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:v94zzPKDww+kZxRttd3FHIXIx/w9606	rogid:q+vEeA0XLST0Zz173bmEt0dNbDE9606	intact-crc:4DB97864629E704F|rigid:3ljoli2ZzCB8ReFigTZbfDCVYno	false	-	his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9UKG1	uniprotkb:P61088	intact:EBI-741243|intact:EBI-28979536|ensembl:ENSP00000288266|ensembl:ENSP00000498115|uniprotkb:Q9P2B9	intact:EBI-1052908|uniprotkb:Q16781|uniprotkb:Q53Y81|ensembl:ENSP00000316176	psi-mi:dp13a_human(display_long)|uniprotkb:Adapter protein containing PH domain, PTB domain and leucine zipper motif 1(gene name synonym)|uniprotkb:APPL1(gene name)|psi-mi:APPL1(display_short)|uniprotkb:APPL(gene name synonym)|uniprotkb:DIP13A(gene name synonym)|uniprotkb:KIAA1428(gene name synonym)	psi-mi:ube2n_human(display_long)|uniprotkb:Ubiquitin-protein ligase N(gene name synonym)|uniprotkb:Ubiquitin carrier protein N(gene name synonym)|uniprotkb:Ubc13(gene name synonym)|uniprotkb:Bendless-like ubiquitin-conjugating enzyme(gene name synonym)|uniprotkb:UBE2N(gene name)|psi-mi:UBE2N(display_short)|uniprotkb:BLU(gene name synonym)|uniprotkb:UbcH13(gene name synonym)|uniprotkb:E2 ubiquitin-conjugating enzyme N(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9972964|imex:IM-22822-132	author-confidence:Z-score = 10.77	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000157500(gene)|ensembl:ENST00000288266(transcript)|ensembl:ENST00000650354(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0007049"(cell cycle)|go:"GO:0007165"(signal transduction)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010008"(endosome membrane)|go:"GO:0010762"(regulation of fibroblast migration)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0023052"(signaling)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032009"(early phagosome)|go:"GO:0033211"(adiponectin-activated signaling pathway)|go:"GO:0034143"(regulation of toll-like receptor 4 signaling pathway)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0035729"(cellular response to hepatocyte growth factor stimulus)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043422"(protein kinase B binding)|go:"GO:0044354"(macropinosome)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045088"(regulation of innate immune response)|go:"GO:0046324"(regulation of glucose import)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0048023"(positive regulation of melanin biosynthetic process)|go:"GO:0048487"(beta-tubulin binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097708"(intracellular vesicle)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|go:"GO:1903076"(regulation of protein localization to plasma membrane)|go:"GO:1905303"(positive regulation of macropinocytosis)|go:"GO:1905450"(negative regulation of Fc-gamma receptor signaling pathway involved in phagocytosis)|interpro:IPR027267|interpro:IPR037929|mint:Q9UKG1|rcsb pdb:2EJ8|rcsb pdb:2ELA|rcsb pdb:2ELB|rcsb pdb:2Q12|rcsb pdb:2Q13|rcsb pdb:2Z0N|rcsb pdb:2Z0O|rcsb pdb:5C5B|reactome:R-HSA-418889|go:"GO:2000045"(regulation of G1/S transition of mitotic cell cycle)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR011993(Pleckstrin homology-type)|refseq:NP_036228.1|ensembl:ENSP00000288266|ensembl:ENSP00000498115|dip:DIP-29322N	refseq:NP_003339.1|dip:DIP-29829N|ensembl:ENSG00000177889(gene)|ensembl:ENST00000318066(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000729"(DNA double-strand break processing)|go:"GO:0001650"(fibrillar center)|go:"GO:0003723"(RNA binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006282"(regulation of DNA repair)|go:"GO:0006301"(postreplication repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016574"(histone ubiquitination)|go:"GO:0031058"(positive regulation of histone modification)|go:"GO:0031372"(UBC13-MMS2 complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033182"(regulation of histone ubiquitination)|go:"GO:0035370"(UBC13-UEV1A complex)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0061631"(ubiquitin conjugating enzyme activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070534"(protein K63-linked ubiquitination)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|interpro:IPR023313|rcsb pdb:1J7D|rcsb pdb:2C2V|rcsb pdb:3HCT|rcsb pdb:3HCU|rcsb pdb:3VON|rcsb pdb:3W31|rcsb pdb:4DHI|rcsb pdb:4DHJ|rcsb pdb:4DHZ|rcsb pdb:4IP3|rcsb pdb:4NR3|rcsb pdb:4NRG|rcsb pdb:4NRI|rcsb pdb:4ONL|rcsb pdb:4ONM|rcsb pdb:4ONN|rcsb pdb:4ORH|rcsb pdb:4TKP|rcsb pdb:4WHV|rcsb pdb:5AIT|rcsb pdb:5AIU|rcsb pdb:5EYA|rcsb pdb:5H7S|rcsb pdb:5VNZ|rcsb pdb:5VO0|rcsb pdb:5YWR|rcsb pdb:6D6I|rcsb pdb:6JKY|rcsb pdb:6KFP|rcsb pdb:6KG6|rcsb pdb:6KL4|rcsb pdb:6LP2|rcsb pdb:6P5B|rcsb pdb:6S53|reactome:R-HSA-168927|reactome:R-HSA-202424|reactome:R-HSA-2871837|reactome:R-HSA-445989|reactome:R-HSA-450302|reactome:R-HSA-450321|reactome:R-HSA-5607764|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-5696395|reactome:R-HSA-69473|reactome:R-HSA-8866654|reactome:R-HSA-9020702|reactome:R-HSA-937039|reactome:R-HSA-937041|reactome:R-HSA-9646399|reactome:R-HSA-975110|reactome:R-HSA-975144|reactome:R-HSA-983168|rcsb pdb:6ULH|rcsb pdb:6UMP|rcsb pdb:6UMS|rcsb pdb:7BBD|rcsb pdb:7BBF|rcsb pdb:7BXG|reactome:R-HSA-1169408|reactome:R-HSA-168638	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S3|resulting-ptm:Q9UKG1 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:v94zzPKDww+kZxRttd3FHIXIx/w9606	rogid:dqdszHlq5FLPHC6UWX6uvkC6Yz89606	intact-crc:4DB97864629E704F|rigid:3ljoli2ZzCB8ReFigTZbfDCVYno	false	-	his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9UJY4	uniprotkb:Q62925	intact:EBI-447646|uniprotkb:O14564|uniprotkb:Q9NYN2|uniprotkb:Q9UPS2|uniprotkb:D3DWF0|ensembl:ENSP00000311962	intact:EBI-636664	psi-mi:gga2_human(display_long)|uniprotkb:Golgi-localized, gamma ear-containing, ARF-binding protein 2(gene name synonym)|uniprotkb:Gamma-adaptin-related protein 2(gene name synonym)|uniprotkb:VHS domain and ear domain of gamma-adaptin(gene name synonym)|uniprotkb:GGA2(gene name)|psi-mi:GGA2(display_short)|uniprotkb:KIAA1080(gene name synonym)	psi-mi:m3k1_rat(display_long)|uniprotkb:MAPK/ERK kinase kinase 1(gene name synonym)|uniprotkb:Map3k1(gene name)|psi-mi:Map3k1(display_short)|uniprotkb:Mekk(gene name synonym)|uniprotkb:Mekk1(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9972939|imex:IM-22822-131	author-confidence:Z-score = 4.43	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_055859.1|dip:DIP-31601N|ensembl:ENSG00000103365(gene)|ensembl:ENST00000309859(transcript)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0010008"(endosome membrane)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031901"(early endosome membrane)|go:"GO:0034394"(protein localization to cell surface)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0043001"(Golgi to plasma membrane protein transport)|go:"GO:0043130"(ubiquitin binding)|interpro:IPR002014(VHS)|interpro:IPR004152(GAT)|interpro:IPR008152(Clathrin adaptor, alpha/beta/gamma-adaptin, appendage, Ig-like subdomain)|interpro:IPR008153(Clathrin adaptor, gamma-adaptin, appendage)|interpro:IPR008942(ENTH/VHS)|interpro:IPR013041(Clathrin/coatomer adaptor, adaptin-like, appendage, Ig-like subdomain)|interpro:IPR038425|interpro:IPR041198|mint:Q9UJY4|rcsb pdb:1MHQ|reactome:R-HSA-8854214|reactome:R-HSA-977225	rgd:620966|refseq:NP_446339.1|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR007527(Zinc finger, SWIM-type)|go:"GO:0000165"(MAPK cascade)|interpro:IPR016024(Armadillo-type fold)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0002011"(morphogenesis of an epithelial sheet)|go:"GO:0003382"(epithelial cell morphogenesis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004706"(JUN kinase kinase kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007254"(JNK cascade)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008432"(JUN kinase binding)|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0016020"(membrane)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0031434"(mitogen-activated protein kinase kinase binding)|go:"GO:0031941"(filamentous actin)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0042060"(wound healing)|go:"GO:0043010"(camera-type eye development)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046625"(sphingolipid binding)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050434"(positive regulation of viral transcription)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0061029"(eyelid development in camera-type eye)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|reactome:R-RNO-166058|reactome:R-RNO-2871796|reactome:R-RNO-975138|reactome:R-RNO-975871|interpro:IPR011989(Armadillo-like helical)|mint:Q62925	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S3|resulting-ptm:Q9UJY4 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:VD3+z3TdZr7Ius0oloo8bnMhwjQ9606	rogid:EwhjYjowkZIAt4UyPcZBUtf9uak10116	intact-crc:2B4D44AB363C2058|rigid:eQensTUc6Llo5kSgFbKE4n4yS2U	false	-	sufficient binding region:433-481(IPR013083)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9UJY4	uniprotkb:Q13404	intact:EBI-447646|uniprotkb:O14564|uniprotkb:Q9NYN2|uniprotkb:Q9UPS2|uniprotkb:D3DWF0|ensembl:ENSP00000311962	intact:EBI-1050671|uniprotkb:Q13403|uniprotkb:Q13532|uniprotkb:Q96H34|uniprotkb:Q9GZT0|uniprotkb:Q9GZW1|uniprotkb:Q9H4J3|uniprotkb:Q9H4J4|uniprotkb:Q9UKL1|uniprotkb:Q9UM48|uniprotkb:Q9UM49|uniprotkb:Q9UM50|uniprotkb:Q5TGE3|uniprotkb:E1P629|uniprotkb:Q5TGE0|ensembl:ENSP00000360739	psi-mi:gga2_human(display_long)|uniprotkb:Golgi-localized, gamma ear-containing, ARF-binding protein 2(gene name synonym)|uniprotkb:Gamma-adaptin-related protein 2(gene name synonym)|uniprotkb:VHS domain and ear domain of gamma-adaptin(gene name synonym)|uniprotkb:GGA2(gene name)|psi-mi:GGA2(display_short)|uniprotkb:KIAA1080(gene name synonym)	psi-mi:ub2v1_human(display_long)|uniprotkb:CROC-1(gene name synonym)|uniprotkb:TRAF6-regulated IKK activator 1 beta Uev1A(gene name synonym)|uniprotkb:P/OKcl.19(orf name)|uniprotkb:UBE2V1(gene name)|psi-mi:UBE2V1(display_short)|uniprotkb:CROC1(gene name synonym)|uniprotkb:UBE2V(gene name synonym)|uniprotkb:UEV1(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9972939|imex:IM-22822-131	author-confidence:Z-score = 4.43	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_055859.1|dip:DIP-31601N|ensembl:ENSG00000103365(gene)|ensembl:ENST00000309859(transcript)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0010008"(endosome membrane)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031901"(early endosome membrane)|go:"GO:0034394"(protein localization to cell surface)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0043001"(Golgi to plasma membrane protein transport)|go:"GO:0043130"(ubiquitin binding)|interpro:IPR002014(VHS)|interpro:IPR004152(GAT)|interpro:IPR008152(Clathrin adaptor, alpha/beta/gamma-adaptin, appendage, Ig-like subdomain)|interpro:IPR008153(Clathrin adaptor, gamma-adaptin, appendage)|interpro:IPR008942(ENTH/VHS)|interpro:IPR013041(Clathrin/coatomer adaptor, adaptin-like, appendage, Ig-like subdomain)|interpro:IPR038425|interpro:IPR041198|mint:Q9UJY4|rcsb pdb:1MHQ|reactome:R-HSA-8854214|reactome:R-HSA-977225	refseq:NP_001027459.1|refseq:NP_068823.2|refseq:NP_071887.1|refseq:NP_954595.1|refseq:NP_954673.1|refseq:NP_001244322.1|refseq:NP_001244323.1|refseq:NP_001244325.1|ensembl:ENSG00000244687(gene)|ensembl:ENST00000371674(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006282"(regulation of DNA repair)|go:"GO:0006301"(postreplication repair)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0030154"(cell differentiation)|go:"GO:0031371"(ubiquitin conjugating enzyme complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035370"(UBC13-UEV1A complex)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070534"(protein K63-linked ubiquitination)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|rcsb pdb:2A4D|rcsb pdb:2C2V|rcsb pdb:2HLW|rcsb pdb:6D6I|reactome:R-HSA-168638|reactome:R-HSA-168927|reactome:R-HSA-202424|reactome:R-HSA-2871837|reactome:R-HSA-445989|reactome:R-HSA-450302|reactome:R-HSA-450321|reactome:R-HSA-5607764|reactome:R-HSA-9020702|reactome:R-HSA-937039|reactome:R-HSA-937041|reactome:R-HSA-9646399|reactome:R-HSA-975110|reactome:R-HSA-975144|reactome:R-HSA-983168|dip:DIP-41911N	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S3|resulting-ptm:Q9UJY4 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:VD3+z3TdZr7Ius0oloo8bnMhwjQ9606	rogid:x95N7Dj2KIqu5gySX59xLmfthUg9606	intact-crc:2B4D44AB363C2058|rigid:eQensTUc6Llo5kSgFbKE4n4yS2U	false	-	his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9UJY4	uniprotkb:P22314	intact:EBI-447646|uniprotkb:O14564|uniprotkb:Q9NYN2|uniprotkb:Q9UPS2|uniprotkb:D3DWF0|ensembl:ENSP00000311962	intact:EBI-709688|uniprotkb:Q96E13|uniprotkb:Q5JRR8|ensembl:ENSP00000338413|ensembl:ENSP00000366568	psi-mi:gga2_human(display_long)|uniprotkb:Golgi-localized, gamma ear-containing, ARF-binding protein 2(gene name synonym)|uniprotkb:Gamma-adaptin-related protein 2(gene name synonym)|uniprotkb:VHS domain and ear domain of gamma-adaptin(gene name synonym)|uniprotkb:GGA2(gene name)|psi-mi:GGA2(display_short)|uniprotkb:KIAA1080(gene name synonym)	psi-mi:uba1_human(display_long)|uniprotkb:Ubiquitin-activating enzyme E1(gene name synonym)|uniprotkb:Protein A1S9(gene name synonym)|uniprotkb:UBA1(gene name)|psi-mi:UBA1(display_short)|uniprotkb:A1S9T(gene name synonym)|uniprotkb:UBE1(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9972939|imex:IM-22822-131	author-confidence:Z-score = 4.43	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_055859.1|dip:DIP-31601N|ensembl:ENSG00000103365(gene)|ensembl:ENST00000309859(transcript)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0010008"(endosome membrane)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031901"(early endosome membrane)|go:"GO:0034394"(protein localization to cell surface)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0043001"(Golgi to plasma membrane protein transport)|go:"GO:0043130"(ubiquitin binding)|interpro:IPR002014(VHS)|interpro:IPR004152(GAT)|interpro:IPR008152(Clathrin adaptor, alpha/beta/gamma-adaptin, appendage, Ig-like subdomain)|interpro:IPR008153(Clathrin adaptor, gamma-adaptin, appendage)|interpro:IPR008942(ENTH/VHS)|interpro:IPR013041(Clathrin/coatomer adaptor, adaptin-like, appendage, Ig-like subdomain)|interpro:IPR038425|interpro:IPR041198|mint:Q9UJY4|rcsb pdb:1MHQ|reactome:R-HSA-8854214|reactome:R-HSA-977225	refseq:NP_003325.2|refseq:NP_695012.1|refseq:XP_016885269.1|refseq:XP_016885270.1|dip:DIP-33686N|ensembl:ENSG00000130985(gene)|ensembl:ENST00000335972(transcript)|ensembl:ENST00000377351(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0004839"(ubiquitin activating enzyme activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0032446"(protein modification by small protein conjugation)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000011(Ubiquitin-activating enzyme, E1)|interpro:IPR000594(UBA/THIF-type NAD/FAD binding fold)|interpro:IPR018074|interpro:IPR018075|interpro:IPR018965|interpro:IPR019572|interpro:IPR032418|interpro:IPR032420|interpro:IPR033127|interpro:IPR035985|interpro:IPR038252|interpro:IPR042063|interpro:IPR042302|interpro:IPR042449|mint:P22314|rcsb pdb:4P22|rcsb pdb:6DC6|reactome:R-HSA-8866652|reactome:R-HSA-983168	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S3|resulting-ptm:Q9UJY4 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:VD3+z3TdZr7Ius0oloo8bnMhwjQ9606	rogid:q+vEeA0XLST0Zz173bmEt0dNbDE9606	intact-crc:2B4D44AB363C2058|rigid:eQensTUc6Llo5kSgFbKE4n4yS2U	false	-	his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9UJY4	uniprotkb:P61088	intact:EBI-447646|uniprotkb:O14564|uniprotkb:Q9NYN2|uniprotkb:Q9UPS2|uniprotkb:D3DWF0|ensembl:ENSP00000311962	intact:EBI-1052908|uniprotkb:Q16781|uniprotkb:Q53Y81|ensembl:ENSP00000316176	psi-mi:gga2_human(display_long)|uniprotkb:Golgi-localized, gamma ear-containing, ARF-binding protein 2(gene name synonym)|uniprotkb:Gamma-adaptin-related protein 2(gene name synonym)|uniprotkb:VHS domain and ear domain of gamma-adaptin(gene name synonym)|uniprotkb:GGA2(gene name)|psi-mi:GGA2(display_short)|uniprotkb:KIAA1080(gene name synonym)	psi-mi:ube2n_human(display_long)|uniprotkb:Ubiquitin-protein ligase N(gene name synonym)|uniprotkb:Ubiquitin carrier protein N(gene name synonym)|uniprotkb:Ubc13(gene name synonym)|uniprotkb:Bendless-like ubiquitin-conjugating enzyme(gene name synonym)|uniprotkb:UBE2N(gene name)|psi-mi:UBE2N(display_short)|uniprotkb:BLU(gene name synonym)|uniprotkb:UbcH13(gene name synonym)|uniprotkb:E2 ubiquitin-conjugating enzyme N(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9972939|imex:IM-22822-131	author-confidence:Z-score = 4.43	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_055859.1|dip:DIP-31601N|ensembl:ENSG00000103365(gene)|ensembl:ENST00000309859(transcript)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0010008"(endosome membrane)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031901"(early endosome membrane)|go:"GO:0034394"(protein localization to cell surface)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0043001"(Golgi to plasma membrane protein transport)|go:"GO:0043130"(ubiquitin binding)|interpro:IPR002014(VHS)|interpro:IPR004152(GAT)|interpro:IPR008152(Clathrin adaptor, alpha/beta/gamma-adaptin, appendage, Ig-like subdomain)|interpro:IPR008153(Clathrin adaptor, gamma-adaptin, appendage)|interpro:IPR008942(ENTH/VHS)|interpro:IPR013041(Clathrin/coatomer adaptor, adaptin-like, appendage, Ig-like subdomain)|interpro:IPR038425|interpro:IPR041198|mint:Q9UJY4|rcsb pdb:1MHQ|reactome:R-HSA-8854214|reactome:R-HSA-977225	refseq:NP_003339.1|dip:DIP-29829N|ensembl:ENSG00000177889(gene)|ensembl:ENST00000318066(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000729"(DNA double-strand break processing)|go:"GO:0001650"(fibrillar center)|go:"GO:0003723"(RNA binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006282"(regulation of DNA repair)|go:"GO:0006301"(postreplication repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016574"(histone ubiquitination)|go:"GO:0031058"(positive regulation of histone modification)|go:"GO:0031372"(UBC13-MMS2 complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033182"(regulation of histone ubiquitination)|go:"GO:0035370"(UBC13-UEV1A complex)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0061631"(ubiquitin conjugating enzyme activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070534"(protein K63-linked ubiquitination)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|interpro:IPR023313|rcsb pdb:1J7D|rcsb pdb:2C2V|rcsb pdb:3HCT|rcsb pdb:3HCU|rcsb pdb:3VON|rcsb pdb:3W31|rcsb pdb:4DHI|rcsb pdb:4DHJ|rcsb pdb:4DHZ|rcsb pdb:4IP3|rcsb pdb:4NR3|rcsb pdb:4NRG|rcsb pdb:4NRI|rcsb pdb:4ONL|rcsb pdb:4ONM|rcsb pdb:4ONN|rcsb pdb:4ORH|rcsb pdb:4TKP|rcsb pdb:4WHV|rcsb pdb:5AIT|rcsb pdb:5AIU|rcsb pdb:5EYA|rcsb pdb:5H7S|rcsb pdb:5VNZ|rcsb pdb:5VO0|rcsb pdb:5YWR|rcsb pdb:6D6I|rcsb pdb:6JKY|rcsb pdb:6KFP|rcsb pdb:6KG6|rcsb pdb:6KL4|rcsb pdb:6LP2|rcsb pdb:6P5B|rcsb pdb:6S53|reactome:R-HSA-168927|reactome:R-HSA-202424|reactome:R-HSA-2871837|reactome:R-HSA-445989|reactome:R-HSA-450302|reactome:R-HSA-450321|reactome:R-HSA-5607764|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-5696395|reactome:R-HSA-69473|reactome:R-HSA-8866654|reactome:R-HSA-9020702|reactome:R-HSA-937039|reactome:R-HSA-937041|reactome:R-HSA-9646399|reactome:R-HSA-975110|reactome:R-HSA-975144|reactome:R-HSA-983168|rcsb pdb:6ULH|rcsb pdb:6UMP|rcsb pdb:6UMS|rcsb pdb:7BBD|rcsb pdb:7BBF|rcsb pdb:7BXG|reactome:R-HSA-1169408|reactome:R-HSA-168638	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S3|resulting-ptm:Q9UJY4 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:VD3+z3TdZr7Ius0oloo8bnMhwjQ9606	rogid:dqdszHlq5FLPHC6UWX6uvkC6Yz89606	intact-crc:2B4D44AB363C2058|rigid:eQensTUc6Llo5kSgFbKE4n4yS2U	false	-	his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q62925	uniprotkb:Q13404	intact:EBI-636664	intact:EBI-1050671|uniprotkb:Q13403|uniprotkb:Q13532|uniprotkb:Q96H34|uniprotkb:Q9GZT0|uniprotkb:Q9GZW1|uniprotkb:Q9H4J3|uniprotkb:Q9H4J4|uniprotkb:Q9UKL1|uniprotkb:Q9UM48|uniprotkb:Q9UM49|uniprotkb:Q9UM50|uniprotkb:Q5TGE3|uniprotkb:E1P629|uniprotkb:Q5TGE0|ensembl:ENSP00000360739	psi-mi:m3k1_rat(display_long)|uniprotkb:MAPK/ERK kinase kinase 1(gene name synonym)|uniprotkb:Map3k1(gene name)|psi-mi:Map3k1(display_short)|uniprotkb:Mekk(gene name synonym)|uniprotkb:Mekk1(gene name synonym)	psi-mi:ub2v1_human(display_long)|uniprotkb:CROC-1(gene name synonym)|uniprotkb:TRAF6-regulated IKK activator 1 beta Uev1A(gene name synonym)|uniprotkb:P/OKcl.19(orf name)|uniprotkb:UBE2V1(gene name)|psi-mi:UBE2V1(display_short)|uniprotkb:CROC1(gene name synonym)|uniprotkb:UBE2V(gene name synonym)|uniprotkb:UEV1(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9972989|imex:IM-22822-133	author-confidence:Z-score = 3.27	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:620966|refseq:NP_446339.1|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR007527(Zinc finger, SWIM-type)|go:"GO:0000165"(MAPK cascade)|interpro:IPR016024(Armadillo-type fold)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0002011"(morphogenesis of an epithelial sheet)|go:"GO:0003382"(epithelial cell morphogenesis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004706"(JUN kinase kinase kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007254"(JNK cascade)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008432"(JUN kinase binding)|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0016020"(membrane)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0031434"(mitogen-activated protein kinase kinase binding)|go:"GO:0031941"(filamentous actin)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0042060"(wound healing)|go:"GO:0043010"(camera-type eye development)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046625"(sphingolipid binding)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050434"(positive regulation of viral transcription)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0061029"(eyelid development in camera-type eye)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|reactome:R-RNO-166058|reactome:R-RNO-2871796|reactome:R-RNO-975138|reactome:R-RNO-975871|interpro:IPR011989(Armadillo-like helical)|mint:Q62925	refseq:NP_001027459.1|refseq:NP_068823.2|refseq:NP_071887.1|refseq:NP_954595.1|refseq:NP_954673.1|refseq:NP_001244322.1|refseq:NP_001244323.1|refseq:NP_001244325.1|ensembl:ENSG00000244687(gene)|ensembl:ENST00000371674(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006282"(regulation of DNA repair)|go:"GO:0006301"(postreplication repair)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0030154"(cell differentiation)|go:"GO:0031371"(ubiquitin conjugating enzyme complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035370"(UBC13-UEV1A complex)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070534"(protein K63-linked ubiquitination)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|rcsb pdb:2A4D|rcsb pdb:2C2V|rcsb pdb:2HLW|rcsb pdb:6D6I|reactome:R-HSA-168638|reactome:R-HSA-168927|reactome:R-HSA-202424|reactome:R-HSA-2871837|reactome:R-HSA-445989|reactome:R-HSA-450302|reactome:R-HSA-450321|reactome:R-HSA-5607764|reactome:R-HSA-9020702|reactome:R-HSA-937039|reactome:R-HSA-937041|reactome:R-HSA-9646399|reactome:R-HSA-975110|reactome:R-HSA-975144|reactome:R-HSA-983168|dip:DIP-41911N	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S3|resulting-ptm:Q9UMX0 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:EwhjYjowkZIAt4UyPcZBUtf9uak10116	rogid:x95N7Dj2KIqu5gySX59xLmfthUg9606	intact-crc:2782F889D606C8C6|rigid:8s9gqd0r2QqUURUWskJG/+fDFLY	false	sufficient binding region:433-481(IPR013083)	his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q62925	uniprotkb:P22314	intact:EBI-636664	intact:EBI-709688|uniprotkb:Q96E13|uniprotkb:Q5JRR8|ensembl:ENSP00000338413|ensembl:ENSP00000366568	psi-mi:m3k1_rat(display_long)|uniprotkb:MAPK/ERK kinase kinase 1(gene name synonym)|uniprotkb:Map3k1(gene name)|psi-mi:Map3k1(display_short)|uniprotkb:Mekk(gene name synonym)|uniprotkb:Mekk1(gene name synonym)	psi-mi:uba1_human(display_long)|uniprotkb:Ubiquitin-activating enzyme E1(gene name synonym)|uniprotkb:Protein A1S9(gene name synonym)|uniprotkb:UBA1(gene name)|psi-mi:UBA1(display_short)|uniprotkb:A1S9T(gene name synonym)|uniprotkb:UBE1(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9972989|imex:IM-22822-133	author-confidence:Z-score = 3.27	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:620966|refseq:NP_446339.1|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR007527(Zinc finger, SWIM-type)|go:"GO:0000165"(MAPK cascade)|interpro:IPR016024(Armadillo-type fold)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0002011"(morphogenesis of an epithelial sheet)|go:"GO:0003382"(epithelial cell morphogenesis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004706"(JUN kinase kinase kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007254"(JNK cascade)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008432"(JUN kinase binding)|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0016020"(membrane)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0031434"(mitogen-activated protein kinase kinase binding)|go:"GO:0031941"(filamentous actin)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0042060"(wound healing)|go:"GO:0043010"(camera-type eye development)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046625"(sphingolipid binding)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050434"(positive regulation of viral transcription)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0061029"(eyelid development in camera-type eye)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|reactome:R-RNO-166058|reactome:R-RNO-2871796|reactome:R-RNO-975138|reactome:R-RNO-975871|interpro:IPR011989(Armadillo-like helical)|mint:Q62925	refseq:NP_003325.2|refseq:NP_695012.1|refseq:XP_016885269.1|refseq:XP_016885270.1|dip:DIP-33686N|ensembl:ENSG00000130985(gene)|ensembl:ENST00000335972(transcript)|ensembl:ENST00000377351(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0004839"(ubiquitin activating enzyme activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0032446"(protein modification by small protein conjugation)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000011(Ubiquitin-activating enzyme, E1)|interpro:IPR000594(UBA/THIF-type NAD/FAD binding fold)|interpro:IPR018074|interpro:IPR018075|interpro:IPR018965|interpro:IPR019572|interpro:IPR032418|interpro:IPR032420|interpro:IPR033127|interpro:IPR035985|interpro:IPR038252|interpro:IPR042063|interpro:IPR042302|interpro:IPR042449|mint:P22314|rcsb pdb:4P22|rcsb pdb:6DC6|reactome:R-HSA-8866652|reactome:R-HSA-983168	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S3|resulting-ptm:Q9UMX0 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:EwhjYjowkZIAt4UyPcZBUtf9uak10116	rogid:q+vEeA0XLST0Zz173bmEt0dNbDE9606	intact-crc:2782F889D606C8C6|rigid:8s9gqd0r2QqUURUWskJG/+fDFLY	false	sufficient binding region:433-481(IPR013083)	his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q62925	uniprotkb:P61088	intact:EBI-636664	intact:EBI-1052908|uniprotkb:Q16781|uniprotkb:Q53Y81|ensembl:ENSP00000316176	psi-mi:m3k1_rat(display_long)|uniprotkb:MAPK/ERK kinase kinase 1(gene name synonym)|uniprotkb:Map3k1(gene name)|psi-mi:Map3k1(display_short)|uniprotkb:Mekk(gene name synonym)|uniprotkb:Mekk1(gene name synonym)	psi-mi:ube2n_human(display_long)|uniprotkb:Ubiquitin-protein ligase N(gene name synonym)|uniprotkb:Ubiquitin carrier protein N(gene name synonym)|uniprotkb:Ubc13(gene name synonym)|uniprotkb:Bendless-like ubiquitin-conjugating enzyme(gene name synonym)|uniprotkb:UBE2N(gene name)|psi-mi:UBE2N(display_short)|uniprotkb:BLU(gene name synonym)|uniprotkb:UbcH13(gene name synonym)|uniprotkb:E2 ubiquitin-conjugating enzyme N(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9972989|imex:IM-22822-133	author-confidence:Z-score = 3.27	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:620966|refseq:NP_446339.1|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR007527(Zinc finger, SWIM-type)|go:"GO:0000165"(MAPK cascade)|interpro:IPR016024(Armadillo-type fold)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0002011"(morphogenesis of an epithelial sheet)|go:"GO:0003382"(epithelial cell morphogenesis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004706"(JUN kinase kinase kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007254"(JNK cascade)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008432"(JUN kinase binding)|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0016020"(membrane)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0031434"(mitogen-activated protein kinase kinase binding)|go:"GO:0031941"(filamentous actin)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0042060"(wound healing)|go:"GO:0043010"(camera-type eye development)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046625"(sphingolipid binding)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050434"(positive regulation of viral transcription)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0061029"(eyelid development in camera-type eye)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|reactome:R-RNO-166058|reactome:R-RNO-2871796|reactome:R-RNO-975138|reactome:R-RNO-975871|interpro:IPR011989(Armadillo-like helical)|mint:Q62925	refseq:NP_003339.1|dip:DIP-29829N|ensembl:ENSG00000177889(gene)|ensembl:ENST00000318066(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000729"(DNA double-strand break processing)|go:"GO:0001650"(fibrillar center)|go:"GO:0003723"(RNA binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006282"(regulation of DNA repair)|go:"GO:0006301"(postreplication repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016574"(histone ubiquitination)|go:"GO:0031058"(positive regulation of histone modification)|go:"GO:0031372"(UBC13-MMS2 complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033182"(regulation of histone ubiquitination)|go:"GO:0035370"(UBC13-UEV1A complex)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0061631"(ubiquitin conjugating enzyme activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070534"(protein K63-linked ubiquitination)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|interpro:IPR023313|rcsb pdb:1J7D|rcsb pdb:2C2V|rcsb pdb:3HCT|rcsb pdb:3HCU|rcsb pdb:3VON|rcsb pdb:3W31|rcsb pdb:4DHI|rcsb pdb:4DHJ|rcsb pdb:4DHZ|rcsb pdb:4IP3|rcsb pdb:4NR3|rcsb pdb:4NRG|rcsb pdb:4NRI|rcsb pdb:4ONL|rcsb pdb:4ONM|rcsb pdb:4ONN|rcsb pdb:4ORH|rcsb pdb:4TKP|rcsb pdb:4WHV|rcsb pdb:5AIT|rcsb pdb:5AIU|rcsb pdb:5EYA|rcsb pdb:5H7S|rcsb pdb:5VNZ|rcsb pdb:5VO0|rcsb pdb:5YWR|rcsb pdb:6D6I|rcsb pdb:6JKY|rcsb pdb:6KFP|rcsb pdb:6KG6|rcsb pdb:6KL4|rcsb pdb:6LP2|rcsb pdb:6P5B|rcsb pdb:6S53|reactome:R-HSA-168927|reactome:R-HSA-202424|reactome:R-HSA-2871837|reactome:R-HSA-445989|reactome:R-HSA-450302|reactome:R-HSA-450321|reactome:R-HSA-5607764|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-5696395|reactome:R-HSA-69473|reactome:R-HSA-8866654|reactome:R-HSA-9020702|reactome:R-HSA-937039|reactome:R-HSA-937041|reactome:R-HSA-9646399|reactome:R-HSA-975110|reactome:R-HSA-975144|reactome:R-HSA-983168|rcsb pdb:6ULH|rcsb pdb:6UMP|rcsb pdb:6UMS|rcsb pdb:7BBD|rcsb pdb:7BBF|rcsb pdb:7BXG|reactome:R-HSA-1169408|reactome:R-HSA-168638	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S3|resulting-ptm:Q9UMX0 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:EwhjYjowkZIAt4UyPcZBUtf9uak10116	rogid:dqdszHlq5FLPHC6UWX6uvkC6Yz89606	intact-crc:2782F889D606C8C6|rigid:8s9gqd0r2QqUURUWskJG/+fDFLY	false	sufficient binding region:433-481(IPR013083)	his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q62925	uniprotkb:Q9UMX0	intact:EBI-636664	intact:EBI-741480|uniprotkb:Q8IXS9|uniprotkb:Q8N2Q3|uniprotkb:Q9H0T8|uniprotkb:Q9H3R4|uniprotkb:Q9HAZ5|intact:EBI-28967608|ensembl:ENSP00000365576|uniprotkb:Q5T6J5|uniprotkb:Q5T6J9|uniprotkb:A0A024R284	psi-mi:m3k1_rat(display_long)|uniprotkb:MAPK/ERK kinase kinase 1(gene name synonym)|uniprotkb:Map3k1(gene name)|psi-mi:Map3k1(display_short)|uniprotkb:Mekk(gene name synonym)|uniprotkb:Mekk1(gene name synonym)	psi-mi:ubql1_human(display_long)|uniprotkb:Protein linking IAP with cytoskeleton 1(gene name synonym)|uniprotkb:UBQLN1(gene name)|psi-mi:UBQLN1(display_short)|uniprotkb:DA41(gene name synonym)|uniprotkb:PLIC1(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9972989|imex:IM-22822-133	author-confidence:Z-score = 3.27	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:620966|refseq:NP_446339.1|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR007527(Zinc finger, SWIM-type)|go:"GO:0000165"(MAPK cascade)|interpro:IPR016024(Armadillo-type fold)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0002011"(morphogenesis of an epithelial sheet)|go:"GO:0003382"(epithelial cell morphogenesis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004706"(JUN kinase kinase kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007254"(JNK cascade)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008432"(JUN kinase binding)|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0016020"(membrane)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0031434"(mitogen-activated protein kinase kinase binding)|go:"GO:0031941"(filamentous actin)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0042060"(wound healing)|go:"GO:0043010"(camera-type eye development)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046625"(sphingolipid binding)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050434"(positive regulation of viral transcription)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0061029"(eyelid development in camera-type eye)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|reactome:R-RNO-166058|reactome:R-RNO-2871796|reactome:R-RNO-975138|reactome:R-RNO-975871|interpro:IPR011989(Armadillo-like helical)|mint:Q62925	ensembl:ENST00000257468|ensembl:ENSP00000257468|ensembl:ENSP00000365576|ensembl:ENSG00000135018(gene)|ensembl:ENST00000376395(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000502"(proteasome complex)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005776"(autophagosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016235"(aggresome)|go:"GO:0016236"(macroautophagy)|go:"GO:0016241"(regulation of macroautophagy)|go:"GO:0019900"(kinase binding)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0031396"(regulation of protein ubiquitination)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031593"(polyubiquitin modification-dependent protein binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035973"(aggrephagy)|go:"GO:0042802"(identical protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0097352"(autophagosome maturation)|go:"GO:1901340"(negative regulation of store-operated calcium channel activity)|go:"GO:1902175"(regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1903071"(positive regulation of ER-associated ubiquitin-dependent protein catabolic process)|interpro:IPR000626(Ubiquitin)|interpro:IPR006636(Heat shock chaperonin-binding)|interpro:IPR009060(UBA-like)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR028430|interpro:IPR029071|mint:Q9UMX0|rcsb pdb:2JY5|rcsb pdb:2JY6|rcsb pdb:2KLC|reactome:R-HSA-8856825|refseq:NP_038466.2|refseq:NP_444295.1|dip:DIP-41629N	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S3|resulting-ptm:Q9UMX0 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:EwhjYjowkZIAt4UyPcZBUtf9uak10116	rogid:nCFfZbGCTvRYaXhQ4R99XblslvM9606	intact-crc:2782F889D606C8C6|rigid:8s9gqd0r2QqUURUWskJG/+fDFLY	false	sufficient binding region:433-481(IPR013083)	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9Y450	uniprotkb:Q62925	intact:EBI-2868258|uniprotkb:Q5T7G3|uniprotkb:Q4VX90|uniprotkb:Q4VX89|uniprotkb:Q9UPW3|uniprotkb:Q8NDW9|uniprotkb:B7Z365|ensembl:ENSP00000356811	intact:EBI-636664	psi-mi:hbs1l_human(display_long)|uniprotkb:HBS1L(gene name)|psi-mi:HBS1L(display_short)|uniprotkb:HBS1(gene name synonym)|uniprotkb:KIAA1038(gene name synonym)|uniprotkb:ERFS(gene name synonym)	psi-mi:m3k1_rat(display_long)|uniprotkb:MAPK/ERK kinase kinase 1(gene name synonym)|uniprotkb:Map3k1(gene name)|psi-mi:Map3k1(display_short)|uniprotkb:Mekk(gene name synonym)|uniprotkb:Mekk1(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9973014|imex:IM-22822-134	author-confidence:Z-score = 10.77	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001138630.1|refseq:NP_001138679.1|refseq:NP_006611.1|interpro:IPR009001(Translation elongation factor EF1A/initiation factor IF2gamma, C-terminal)|interpro:IPR015033(Region of unknown function DUF1916)|interpro:IPR027417|interpro:IPR037189|mint:Q9Y450|rcsb pdb:5LZW|rcsb pdb:5LZX|rcsb pdb:5LZY|rcsb pdb:5LZZ|reactome:R-HSA-429958|ensembl:ENSG00000112339(gene)|ensembl:ENST00000367837(transcript)|go:"GO:0003746"(translation elongation factor activity)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005829"(cytosol)|go:"GO:0006412"(translation)|go:"GO:0007165"(signal transduction)|go:"GO:0016020"(membrane)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000795(Protein synthesis factor, GTP-binding)|interpro:IPR004160(Translation elongation factor EFTu/EF1A, C-terminal)|interpro:IPR004161(Translation elongation factor EFTu/EF1A, domain 2)|interpro:IPR009000(Translation elongation and initiation factors/Ribosomal, beta-barrel)	rgd:620966|refseq:NP_446339.1|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR007527(Zinc finger, SWIM-type)|go:"GO:0000165"(MAPK cascade)|interpro:IPR016024(Armadillo-type fold)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0002011"(morphogenesis of an epithelial sheet)|go:"GO:0003382"(epithelial cell morphogenesis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004706"(JUN kinase kinase kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007254"(JNK cascade)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008432"(JUN kinase binding)|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0016020"(membrane)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0031434"(mitogen-activated protein kinase kinase binding)|go:"GO:0031941"(filamentous actin)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0042060"(wound healing)|go:"GO:0043010"(camera-type eye development)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046625"(sphingolipid binding)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050434"(positive regulation of viral transcription)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0061029"(eyelid development in camera-type eye)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|reactome:R-RNO-166058|reactome:R-RNO-2871796|reactome:R-RNO-975138|reactome:R-RNO-975871|interpro:IPR011989(Armadillo-like helical)|mint:Q62925	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S3|resulting-ptm:Q9Y450 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:j93qk+f9rW1/Sem+tUzRay6UcKw9606	rogid:EwhjYjowkZIAt4UyPcZBUtf9uak10116	intact-crc:C7964548DEA25C28|rigid:NRegxyjweSPkxb74Gywpwyw88H8	false	-	sufficient binding region:433-481(IPR013083)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9Y450	uniprotkb:Q13404	intact:EBI-2868258|uniprotkb:Q5T7G3|uniprotkb:Q4VX90|uniprotkb:Q4VX89|uniprotkb:Q9UPW3|uniprotkb:Q8NDW9|uniprotkb:B7Z365|ensembl:ENSP00000356811	intact:EBI-1050671|uniprotkb:Q13403|uniprotkb:Q13532|uniprotkb:Q96H34|uniprotkb:Q9GZT0|uniprotkb:Q9GZW1|uniprotkb:Q9H4J3|uniprotkb:Q9H4J4|uniprotkb:Q9UKL1|uniprotkb:Q9UM48|uniprotkb:Q9UM49|uniprotkb:Q9UM50|uniprotkb:Q5TGE3|uniprotkb:E1P629|uniprotkb:Q5TGE0|ensembl:ENSP00000360739	psi-mi:hbs1l_human(display_long)|uniprotkb:HBS1L(gene name)|psi-mi:HBS1L(display_short)|uniprotkb:HBS1(gene name synonym)|uniprotkb:KIAA1038(gene name synonym)|uniprotkb:ERFS(gene name synonym)	psi-mi:ub2v1_human(display_long)|uniprotkb:CROC-1(gene name synonym)|uniprotkb:TRAF6-regulated IKK activator 1 beta Uev1A(gene name synonym)|uniprotkb:P/OKcl.19(orf name)|uniprotkb:UBE2V1(gene name)|psi-mi:UBE2V1(display_short)|uniprotkb:CROC1(gene name synonym)|uniprotkb:UBE2V(gene name synonym)|uniprotkb:UEV1(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9973014|imex:IM-22822-134	author-confidence:Z-score = 10.77	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001138630.1|refseq:NP_001138679.1|refseq:NP_006611.1|interpro:IPR009001(Translation elongation factor EF1A/initiation factor IF2gamma, C-terminal)|interpro:IPR015033(Region of unknown function DUF1916)|interpro:IPR027417|interpro:IPR037189|mint:Q9Y450|rcsb pdb:5LZW|rcsb pdb:5LZX|rcsb pdb:5LZY|rcsb pdb:5LZZ|reactome:R-HSA-429958|ensembl:ENSG00000112339(gene)|ensembl:ENST00000367837(transcript)|go:"GO:0003746"(translation elongation factor activity)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005829"(cytosol)|go:"GO:0006412"(translation)|go:"GO:0007165"(signal transduction)|go:"GO:0016020"(membrane)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000795(Protein synthesis factor, GTP-binding)|interpro:IPR004160(Translation elongation factor EFTu/EF1A, C-terminal)|interpro:IPR004161(Translation elongation factor EFTu/EF1A, domain 2)|interpro:IPR009000(Translation elongation and initiation factors/Ribosomal, beta-barrel)	refseq:NP_001027459.1|refseq:NP_068823.2|refseq:NP_071887.1|refseq:NP_954595.1|refseq:NP_954673.1|refseq:NP_001244322.1|refseq:NP_001244323.1|refseq:NP_001244325.1|ensembl:ENSG00000244687(gene)|ensembl:ENST00000371674(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006282"(regulation of DNA repair)|go:"GO:0006301"(postreplication repair)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0030154"(cell differentiation)|go:"GO:0031371"(ubiquitin conjugating enzyme complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035370"(UBC13-UEV1A complex)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070534"(protein K63-linked ubiquitination)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|rcsb pdb:2A4D|rcsb pdb:2C2V|rcsb pdb:2HLW|rcsb pdb:6D6I|reactome:R-HSA-168638|reactome:R-HSA-168927|reactome:R-HSA-202424|reactome:R-HSA-2871837|reactome:R-HSA-445989|reactome:R-HSA-450302|reactome:R-HSA-450321|reactome:R-HSA-5607764|reactome:R-HSA-9020702|reactome:R-HSA-937039|reactome:R-HSA-937041|reactome:R-HSA-9646399|reactome:R-HSA-975110|reactome:R-HSA-975144|reactome:R-HSA-983168|dip:DIP-41911N	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S3|resulting-ptm:Q9Y450 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:j93qk+f9rW1/Sem+tUzRay6UcKw9606	rogid:x95N7Dj2KIqu5gySX59xLmfthUg9606	intact-crc:C7964548DEA25C28|rigid:NRegxyjweSPkxb74Gywpwyw88H8	false	-	his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9Y450	uniprotkb:P22314	intact:EBI-2868258|uniprotkb:Q5T7G3|uniprotkb:Q4VX90|uniprotkb:Q4VX89|uniprotkb:Q9UPW3|uniprotkb:Q8NDW9|uniprotkb:B7Z365|ensembl:ENSP00000356811	intact:EBI-709688|uniprotkb:Q96E13|uniprotkb:Q5JRR8|ensembl:ENSP00000338413|ensembl:ENSP00000366568	psi-mi:hbs1l_human(display_long)|uniprotkb:HBS1L(gene name)|psi-mi:HBS1L(display_short)|uniprotkb:HBS1(gene name synonym)|uniprotkb:KIAA1038(gene name synonym)|uniprotkb:ERFS(gene name synonym)	psi-mi:uba1_human(display_long)|uniprotkb:Ubiquitin-activating enzyme E1(gene name synonym)|uniprotkb:Protein A1S9(gene name synonym)|uniprotkb:UBA1(gene name)|psi-mi:UBA1(display_short)|uniprotkb:A1S9T(gene name synonym)|uniprotkb:UBE1(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9973014|imex:IM-22822-134	author-confidence:Z-score = 10.77	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001138630.1|refseq:NP_001138679.1|refseq:NP_006611.1|interpro:IPR009001(Translation elongation factor EF1A/initiation factor IF2gamma, C-terminal)|interpro:IPR015033(Region of unknown function DUF1916)|interpro:IPR027417|interpro:IPR037189|mint:Q9Y450|rcsb pdb:5LZW|rcsb pdb:5LZX|rcsb pdb:5LZY|rcsb pdb:5LZZ|reactome:R-HSA-429958|ensembl:ENSG00000112339(gene)|ensembl:ENST00000367837(transcript)|go:"GO:0003746"(translation elongation factor activity)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005829"(cytosol)|go:"GO:0006412"(translation)|go:"GO:0007165"(signal transduction)|go:"GO:0016020"(membrane)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000795(Protein synthesis factor, GTP-binding)|interpro:IPR004160(Translation elongation factor EFTu/EF1A, C-terminal)|interpro:IPR004161(Translation elongation factor EFTu/EF1A, domain 2)|interpro:IPR009000(Translation elongation and initiation factors/Ribosomal, beta-barrel)	refseq:NP_003325.2|refseq:NP_695012.1|refseq:XP_016885269.1|refseq:XP_016885270.1|dip:DIP-33686N|ensembl:ENSG00000130985(gene)|ensembl:ENST00000335972(transcript)|ensembl:ENST00000377351(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0004839"(ubiquitin activating enzyme activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0032446"(protein modification by small protein conjugation)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000011(Ubiquitin-activating enzyme, E1)|interpro:IPR000594(UBA/THIF-type NAD/FAD binding fold)|interpro:IPR018074|interpro:IPR018075|interpro:IPR018965|interpro:IPR019572|interpro:IPR032418|interpro:IPR032420|interpro:IPR033127|interpro:IPR035985|interpro:IPR038252|interpro:IPR042063|interpro:IPR042302|interpro:IPR042449|mint:P22314|rcsb pdb:4P22|rcsb pdb:6DC6|reactome:R-HSA-8866652|reactome:R-HSA-983168	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S3|resulting-ptm:Q9Y450 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:j93qk+f9rW1/Sem+tUzRay6UcKw9606	rogid:q+vEeA0XLST0Zz173bmEt0dNbDE9606	intact-crc:C7964548DEA25C28|rigid:NRegxyjweSPkxb74Gywpwyw88H8	false	-	his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9Y450	uniprotkb:P61088	intact:EBI-2868258|uniprotkb:Q5T7G3|uniprotkb:Q4VX90|uniprotkb:Q4VX89|uniprotkb:Q9UPW3|uniprotkb:Q8NDW9|uniprotkb:B7Z365|ensembl:ENSP00000356811	intact:EBI-1052908|uniprotkb:Q16781|uniprotkb:Q53Y81|ensembl:ENSP00000316176	psi-mi:hbs1l_human(display_long)|uniprotkb:HBS1L(gene name)|psi-mi:HBS1L(display_short)|uniprotkb:HBS1(gene name synonym)|uniprotkb:KIAA1038(gene name synonym)|uniprotkb:ERFS(gene name synonym)	psi-mi:ube2n_human(display_long)|uniprotkb:Ubiquitin-protein ligase N(gene name synonym)|uniprotkb:Ubiquitin carrier protein N(gene name synonym)|uniprotkb:Ubc13(gene name synonym)|uniprotkb:Bendless-like ubiquitin-conjugating enzyme(gene name synonym)|uniprotkb:UBE2N(gene name)|psi-mi:UBE2N(display_short)|uniprotkb:BLU(gene name synonym)|uniprotkb:UbcH13(gene name synonym)|uniprotkb:E2 ubiquitin-conjugating enzyme N(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9973014|imex:IM-22822-134	author-confidence:Z-score = 10.77	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001138630.1|refseq:NP_001138679.1|refseq:NP_006611.1|interpro:IPR009001(Translation elongation factor EF1A/initiation factor IF2gamma, C-terminal)|interpro:IPR015033(Region of unknown function DUF1916)|interpro:IPR027417|interpro:IPR037189|mint:Q9Y450|rcsb pdb:5LZW|rcsb pdb:5LZX|rcsb pdb:5LZY|rcsb pdb:5LZZ|reactome:R-HSA-429958|ensembl:ENSG00000112339(gene)|ensembl:ENST00000367837(transcript)|go:"GO:0003746"(translation elongation factor activity)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005829"(cytosol)|go:"GO:0006412"(translation)|go:"GO:0007165"(signal transduction)|go:"GO:0016020"(membrane)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000795(Protein synthesis factor, GTP-binding)|interpro:IPR004160(Translation elongation factor EFTu/EF1A, C-terminal)|interpro:IPR004161(Translation elongation factor EFTu/EF1A, domain 2)|interpro:IPR009000(Translation elongation and initiation factors/Ribosomal, beta-barrel)	refseq:NP_003339.1|dip:DIP-29829N|ensembl:ENSG00000177889(gene)|ensembl:ENST00000318066(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000729"(DNA double-strand break processing)|go:"GO:0001650"(fibrillar center)|go:"GO:0003723"(RNA binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006282"(regulation of DNA repair)|go:"GO:0006301"(postreplication repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016574"(histone ubiquitination)|go:"GO:0031058"(positive regulation of histone modification)|go:"GO:0031372"(UBC13-MMS2 complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033182"(regulation of histone ubiquitination)|go:"GO:0035370"(UBC13-UEV1A complex)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0061631"(ubiquitin conjugating enzyme activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070534"(protein K63-linked ubiquitination)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|interpro:IPR023313|rcsb pdb:1J7D|rcsb pdb:2C2V|rcsb pdb:3HCT|rcsb pdb:3HCU|rcsb pdb:3VON|rcsb pdb:3W31|rcsb pdb:4DHI|rcsb pdb:4DHJ|rcsb pdb:4DHZ|rcsb pdb:4IP3|rcsb pdb:4NR3|rcsb pdb:4NRG|rcsb pdb:4NRI|rcsb pdb:4ONL|rcsb pdb:4ONM|rcsb pdb:4ONN|rcsb pdb:4ORH|rcsb pdb:4TKP|rcsb pdb:4WHV|rcsb pdb:5AIT|rcsb pdb:5AIU|rcsb pdb:5EYA|rcsb pdb:5H7S|rcsb pdb:5VNZ|rcsb pdb:5VO0|rcsb pdb:5YWR|rcsb pdb:6D6I|rcsb pdb:6JKY|rcsb pdb:6KFP|rcsb pdb:6KG6|rcsb pdb:6KL4|rcsb pdb:6LP2|rcsb pdb:6P5B|rcsb pdb:6S53|reactome:R-HSA-168927|reactome:R-HSA-202424|reactome:R-HSA-2871837|reactome:R-HSA-445989|reactome:R-HSA-450302|reactome:R-HSA-450321|reactome:R-HSA-5607764|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-5696395|reactome:R-HSA-69473|reactome:R-HSA-8866654|reactome:R-HSA-9020702|reactome:R-HSA-937039|reactome:R-HSA-937041|reactome:R-HSA-9646399|reactome:R-HSA-975110|reactome:R-HSA-975144|reactome:R-HSA-983168|rcsb pdb:6ULH|rcsb pdb:6UMP|rcsb pdb:6UMS|rcsb pdb:7BBD|rcsb pdb:7BBF|rcsb pdb:7BXG|reactome:R-HSA-1169408|reactome:R-HSA-168638	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S3|resulting-ptm:Q9Y450 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:j93qk+f9rW1/Sem+tUzRay6UcKw9606	rogid:dqdszHlq5FLPHC6UWX6uvkC6Yz89606	intact-crc:C7964548DEA25C28|rigid:NRegxyjweSPkxb74Gywpwyw88H8	false	-	his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q62925	uniprotkb:Q9Y508	intact:EBI-636664	intact:EBI-723587|uniprotkb:Q6N0B0|uniprotkb:B2RDQ9|uniprotkb:B4DWY5|uniprotkb:E1P627|ensembl:ENSP00000244061	psi-mi:m3k1_rat(display_long)|uniprotkb:MAPK/ERK kinase kinase 1(gene name synonym)|uniprotkb:Map3k1(gene name)|psi-mi:Map3k1(display_short)|uniprotkb:Mekk(gene name synonym)|uniprotkb:Mekk1(gene name synonym)	psi-mi:rn114_human(display_long)|uniprotkb:Zinc finger protein 313(gene name synonym)|uniprotkb:RNF114(gene name)|psi-mi:RNF114(display_short)|uniprotkb:ZNF313(gene name synonym)|uniprotkb:ZNF228(gene name synonym)|uniprotkb:Zinc finger protein 228(gene name synonym)|uniprotkb:RING finger protein 114(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase RNF114(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9973039|imex:IM-22822-135	author-confidence:Z-score = 6.52	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:620966|refseq:NP_446339.1|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR007527(Zinc finger, SWIM-type)|go:"GO:0000165"(MAPK cascade)|interpro:IPR016024(Armadillo-type fold)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0002011"(morphogenesis of an epithelial sheet)|go:"GO:0003382"(epithelial cell morphogenesis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004706"(JUN kinase kinase kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007254"(JNK cascade)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008432"(JUN kinase binding)|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0016020"(membrane)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0031434"(mitogen-activated protein kinase kinase binding)|go:"GO:0031941"(filamentous actin)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0042060"(wound healing)|go:"GO:0043010"(camera-type eye development)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046625"(sphingolipid binding)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050434"(positive regulation of viral transcription)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0061029"(eyelid development in camera-type eye)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|reactome:R-RNO-166058|reactome:R-RNO-2871796|reactome:R-RNO-975138|reactome:R-RNO-975871|interpro:IPR011989(Armadillo-like helical)|mint:Q62925	refseq:NP_061153.1|ensembl:ENSG00000124226(gene)|ensembl:ENST00000244061(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0007283"(spermatogenesis)|go:"GO:0030154"(cell differentiation)|go:"GO:0046872"(metal ion binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR008598(Drought induced 19)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR027370|interpro:IPR034734|interpro:IPR042716|reactome:R-HSA-983168	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S3|resulting-ptm:Q9Y508 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:EwhjYjowkZIAt4UyPcZBUtf9uak10116	rogid:R1fX8xaGuIhy/M6cLzPeyfJBf649606	intact-crc:8E7DABF2975C8181|rigid:VcNmrcygRll0d03QVc3i7EZheE4	false	sufficient binding region:433-481(IPR013083)	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q62925	uniprotkb:Q13404	intact:EBI-636664	intact:EBI-1050671|uniprotkb:Q13403|uniprotkb:Q13532|uniprotkb:Q96H34|uniprotkb:Q9GZT0|uniprotkb:Q9GZW1|uniprotkb:Q9H4J3|uniprotkb:Q9H4J4|uniprotkb:Q9UKL1|uniprotkb:Q9UM48|uniprotkb:Q9UM49|uniprotkb:Q9UM50|uniprotkb:Q5TGE3|uniprotkb:E1P629|uniprotkb:Q5TGE0|ensembl:ENSP00000360739	psi-mi:m3k1_rat(display_long)|uniprotkb:MAPK/ERK kinase kinase 1(gene name synonym)|uniprotkb:Map3k1(gene name)|psi-mi:Map3k1(display_short)|uniprotkb:Mekk(gene name synonym)|uniprotkb:Mekk1(gene name synonym)	psi-mi:ub2v1_human(display_long)|uniprotkb:CROC-1(gene name synonym)|uniprotkb:TRAF6-regulated IKK activator 1 beta Uev1A(gene name synonym)|uniprotkb:P/OKcl.19(orf name)|uniprotkb:UBE2V1(gene name)|psi-mi:UBE2V1(display_short)|uniprotkb:CROC1(gene name synonym)|uniprotkb:UBE2V(gene name synonym)|uniprotkb:UEV1(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9973039|imex:IM-22822-135	author-confidence:Z-score = 6.52	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:620966|refseq:NP_446339.1|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR007527(Zinc finger, SWIM-type)|go:"GO:0000165"(MAPK cascade)|interpro:IPR016024(Armadillo-type fold)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0002011"(morphogenesis of an epithelial sheet)|go:"GO:0003382"(epithelial cell morphogenesis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004706"(JUN kinase kinase kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007254"(JNK cascade)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008432"(JUN kinase binding)|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0016020"(membrane)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0031434"(mitogen-activated protein kinase kinase binding)|go:"GO:0031941"(filamentous actin)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0042060"(wound healing)|go:"GO:0043010"(camera-type eye development)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046625"(sphingolipid binding)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050434"(positive regulation of viral transcription)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0061029"(eyelid development in camera-type eye)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|reactome:R-RNO-166058|reactome:R-RNO-2871796|reactome:R-RNO-975138|reactome:R-RNO-975871|interpro:IPR011989(Armadillo-like helical)|mint:Q62925	refseq:NP_001027459.1|refseq:NP_068823.2|refseq:NP_071887.1|refseq:NP_954595.1|refseq:NP_954673.1|refseq:NP_001244322.1|refseq:NP_001244323.1|refseq:NP_001244325.1|ensembl:ENSG00000244687(gene)|ensembl:ENST00000371674(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006282"(regulation of DNA repair)|go:"GO:0006301"(postreplication repair)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0030154"(cell differentiation)|go:"GO:0031371"(ubiquitin conjugating enzyme complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035370"(UBC13-UEV1A complex)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070534"(protein K63-linked ubiquitination)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|rcsb pdb:2A4D|rcsb pdb:2C2V|rcsb pdb:2HLW|rcsb pdb:6D6I|reactome:R-HSA-168638|reactome:R-HSA-168927|reactome:R-HSA-202424|reactome:R-HSA-2871837|reactome:R-HSA-445989|reactome:R-HSA-450302|reactome:R-HSA-450321|reactome:R-HSA-5607764|reactome:R-HSA-9020702|reactome:R-HSA-937039|reactome:R-HSA-937041|reactome:R-HSA-9646399|reactome:R-HSA-975110|reactome:R-HSA-975144|reactome:R-HSA-983168|dip:DIP-41911N	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S3|resulting-ptm:Q9Y508 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:EwhjYjowkZIAt4UyPcZBUtf9uak10116	rogid:x95N7Dj2KIqu5gySX59xLmfthUg9606	intact-crc:8E7DABF2975C8181|rigid:VcNmrcygRll0d03QVc3i7EZheE4	false	sufficient binding region:433-481(IPR013083)	his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q62925	uniprotkb:P22314	intact:EBI-636664	intact:EBI-709688|uniprotkb:Q96E13|uniprotkb:Q5JRR8|ensembl:ENSP00000338413|ensembl:ENSP00000366568	psi-mi:m3k1_rat(display_long)|uniprotkb:MAPK/ERK kinase kinase 1(gene name synonym)|uniprotkb:Map3k1(gene name)|psi-mi:Map3k1(display_short)|uniprotkb:Mekk(gene name synonym)|uniprotkb:Mekk1(gene name synonym)	psi-mi:uba1_human(display_long)|uniprotkb:Ubiquitin-activating enzyme E1(gene name synonym)|uniprotkb:Protein A1S9(gene name synonym)|uniprotkb:UBA1(gene name)|psi-mi:UBA1(display_short)|uniprotkb:A1S9T(gene name synonym)|uniprotkb:UBE1(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9973039|imex:IM-22822-135	author-confidence:Z-score = 6.52	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:620966|refseq:NP_446339.1|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR007527(Zinc finger, SWIM-type)|go:"GO:0000165"(MAPK cascade)|interpro:IPR016024(Armadillo-type fold)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0002011"(morphogenesis of an epithelial sheet)|go:"GO:0003382"(epithelial cell morphogenesis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004706"(JUN kinase kinase kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007254"(JNK cascade)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008432"(JUN kinase binding)|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0016020"(membrane)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0031434"(mitogen-activated protein kinase kinase binding)|go:"GO:0031941"(filamentous actin)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0042060"(wound healing)|go:"GO:0043010"(camera-type eye development)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046625"(sphingolipid binding)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050434"(positive regulation of viral transcription)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0061029"(eyelid development in camera-type eye)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|reactome:R-RNO-166058|reactome:R-RNO-2871796|reactome:R-RNO-975138|reactome:R-RNO-975871|interpro:IPR011989(Armadillo-like helical)|mint:Q62925	refseq:NP_003325.2|refseq:NP_695012.1|refseq:XP_016885269.1|refseq:XP_016885270.1|dip:DIP-33686N|ensembl:ENSG00000130985(gene)|ensembl:ENST00000335972(transcript)|ensembl:ENST00000377351(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0004839"(ubiquitin activating enzyme activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0032446"(protein modification by small protein conjugation)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000011(Ubiquitin-activating enzyme, E1)|interpro:IPR000594(UBA/THIF-type NAD/FAD binding fold)|interpro:IPR018074|interpro:IPR018075|interpro:IPR018965|interpro:IPR019572|interpro:IPR032418|interpro:IPR032420|interpro:IPR033127|interpro:IPR035985|interpro:IPR038252|interpro:IPR042063|interpro:IPR042302|interpro:IPR042449|mint:P22314|rcsb pdb:4P22|rcsb pdb:6DC6|reactome:R-HSA-8866652|reactome:R-HSA-983168	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S3|resulting-ptm:Q9Y508 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:EwhjYjowkZIAt4UyPcZBUtf9uak10116	rogid:q+vEeA0XLST0Zz173bmEt0dNbDE9606	intact-crc:8E7DABF2975C8181|rigid:VcNmrcygRll0d03QVc3i7EZheE4	false	sufficient binding region:433-481(IPR013083)	his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q62925	uniprotkb:P61088	intact:EBI-636664	intact:EBI-1052908|uniprotkb:Q16781|uniprotkb:Q53Y81|ensembl:ENSP00000316176	psi-mi:m3k1_rat(display_long)|uniprotkb:MAPK/ERK kinase kinase 1(gene name synonym)|uniprotkb:Map3k1(gene name)|psi-mi:Map3k1(display_short)|uniprotkb:Mekk(gene name synonym)|uniprotkb:Mekk1(gene name synonym)	psi-mi:ube2n_human(display_long)|uniprotkb:Ubiquitin-protein ligase N(gene name synonym)|uniprotkb:Ubiquitin carrier protein N(gene name synonym)|uniprotkb:Ubc13(gene name synonym)|uniprotkb:Bendless-like ubiquitin-conjugating enzyme(gene name synonym)|uniprotkb:UBE2N(gene name)|psi-mi:UBE2N(display_short)|uniprotkb:BLU(gene name synonym)|uniprotkb:UbcH13(gene name synonym)|uniprotkb:E2 ubiquitin-conjugating enzyme N(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9973039|imex:IM-22822-135	author-confidence:Z-score = 6.52	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:620966|refseq:NP_446339.1|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR007527(Zinc finger, SWIM-type)|go:"GO:0000165"(MAPK cascade)|interpro:IPR016024(Armadillo-type fold)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0002011"(morphogenesis of an epithelial sheet)|go:"GO:0003382"(epithelial cell morphogenesis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004706"(JUN kinase kinase kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007254"(JNK cascade)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008432"(JUN kinase binding)|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0016020"(membrane)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0031434"(mitogen-activated protein kinase kinase binding)|go:"GO:0031941"(filamentous actin)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0042060"(wound healing)|go:"GO:0043010"(camera-type eye development)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046625"(sphingolipid binding)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050434"(positive regulation of viral transcription)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0061029"(eyelid development in camera-type eye)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|reactome:R-RNO-166058|reactome:R-RNO-2871796|reactome:R-RNO-975138|reactome:R-RNO-975871|interpro:IPR011989(Armadillo-like helical)|mint:Q62925	refseq:NP_003339.1|dip:DIP-29829N|ensembl:ENSG00000177889(gene)|ensembl:ENST00000318066(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000729"(DNA double-strand break processing)|go:"GO:0001650"(fibrillar center)|go:"GO:0003723"(RNA binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006282"(regulation of DNA repair)|go:"GO:0006301"(postreplication repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016574"(histone ubiquitination)|go:"GO:0031058"(positive regulation of histone modification)|go:"GO:0031372"(UBC13-MMS2 complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033182"(regulation of histone ubiquitination)|go:"GO:0035370"(UBC13-UEV1A complex)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0061631"(ubiquitin conjugating enzyme activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070534"(protein K63-linked ubiquitination)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|interpro:IPR023313|rcsb pdb:1J7D|rcsb pdb:2C2V|rcsb pdb:3HCT|rcsb pdb:3HCU|rcsb pdb:3VON|rcsb pdb:3W31|rcsb pdb:4DHI|rcsb pdb:4DHJ|rcsb pdb:4DHZ|rcsb pdb:4IP3|rcsb pdb:4NR3|rcsb pdb:4NRG|rcsb pdb:4NRI|rcsb pdb:4ONL|rcsb pdb:4ONM|rcsb pdb:4ONN|rcsb pdb:4ORH|rcsb pdb:4TKP|rcsb pdb:4WHV|rcsb pdb:5AIT|rcsb pdb:5AIU|rcsb pdb:5EYA|rcsb pdb:5H7S|rcsb pdb:5VNZ|rcsb pdb:5VO0|rcsb pdb:5YWR|rcsb pdb:6D6I|rcsb pdb:6JKY|rcsb pdb:6KFP|rcsb pdb:6KG6|rcsb pdb:6KL4|rcsb pdb:6LP2|rcsb pdb:6P5B|rcsb pdb:6S53|reactome:R-HSA-168927|reactome:R-HSA-202424|reactome:R-HSA-2871837|reactome:R-HSA-445989|reactome:R-HSA-450302|reactome:R-HSA-450321|reactome:R-HSA-5607764|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-5696395|reactome:R-HSA-69473|reactome:R-HSA-8866654|reactome:R-HSA-9020702|reactome:R-HSA-937039|reactome:R-HSA-937041|reactome:R-HSA-9646399|reactome:R-HSA-975110|reactome:R-HSA-975144|reactome:R-HSA-983168|rcsb pdb:6ULH|rcsb pdb:6UMP|rcsb pdb:6UMS|rcsb pdb:7BBD|rcsb pdb:7BBF|rcsb pdb:7BXG|reactome:R-HSA-1169408|reactome:R-HSA-168638	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S3|resulting-ptm:Q9Y508 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:EwhjYjowkZIAt4UyPcZBUtf9uak10116	rogid:dqdszHlq5FLPHC6UWX6uvkC6Yz89606	intact-crc:8E7DABF2975C8181|rigid:VcNmrcygRll0d03QVc3i7EZheE4	false	sufficient binding region:433-481(IPR013083)	his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q62925	uniprotkb:Q13404	intact:EBI-636664	intact:EBI-1050671|uniprotkb:Q13403|uniprotkb:Q13532|uniprotkb:Q96H34|uniprotkb:Q9GZT0|uniprotkb:Q9GZW1|uniprotkb:Q9H4J3|uniprotkb:Q9H4J4|uniprotkb:Q9UKL1|uniprotkb:Q9UM48|uniprotkb:Q9UM49|uniprotkb:Q9UM50|uniprotkb:Q5TGE3|uniprotkb:E1P629|uniprotkb:Q5TGE0|ensembl:ENSP00000360739	psi-mi:m3k1_rat(display_long)|uniprotkb:MAPK/ERK kinase kinase 1(gene name synonym)|uniprotkb:Map3k1(gene name)|psi-mi:Map3k1(display_short)|uniprotkb:Mekk(gene name synonym)|uniprotkb:Mekk1(gene name synonym)	psi-mi:ub2v1_human(display_long)|uniprotkb:CROC-1(gene name synonym)|uniprotkb:TRAF6-regulated IKK activator 1 beta Uev1A(gene name synonym)|uniprotkb:P/OKcl.19(orf name)|uniprotkb:UBE2V1(gene name)|psi-mi:UBE2V1(display_short)|uniprotkb:CROC1(gene name synonym)|uniprotkb:UBE2V(gene name synonym)|uniprotkb:UEV1(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9973064|imex:IM-22822-136	author-confidence:Z-score = 6.27	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:620966|refseq:NP_446339.1|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR007527(Zinc finger, SWIM-type)|go:"GO:0000165"(MAPK cascade)|interpro:IPR016024(Armadillo-type fold)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0002011"(morphogenesis of an epithelial sheet)|go:"GO:0003382"(epithelial cell morphogenesis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004706"(JUN kinase kinase kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007254"(JNK cascade)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008432"(JUN kinase binding)|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0016020"(membrane)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0031434"(mitogen-activated protein kinase kinase binding)|go:"GO:0031941"(filamentous actin)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0042060"(wound healing)|go:"GO:0043010"(camera-type eye development)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046625"(sphingolipid binding)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050434"(positive regulation of viral transcription)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0061029"(eyelid development in camera-type eye)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|reactome:R-RNO-166058|reactome:R-RNO-2871796|reactome:R-RNO-975138|reactome:R-RNO-975871|interpro:IPR011989(Armadillo-like helical)|mint:Q62925	refseq:NP_001027459.1|refseq:NP_068823.2|refseq:NP_071887.1|refseq:NP_954595.1|refseq:NP_954673.1|refseq:NP_001244322.1|refseq:NP_001244323.1|refseq:NP_001244325.1|ensembl:ENSG00000244687(gene)|ensembl:ENST00000371674(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006282"(regulation of DNA repair)|go:"GO:0006301"(postreplication repair)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0030154"(cell differentiation)|go:"GO:0031371"(ubiquitin conjugating enzyme complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035370"(UBC13-UEV1A complex)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070534"(protein K63-linked ubiquitination)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|rcsb pdb:2A4D|rcsb pdb:2C2V|rcsb pdb:2HLW|rcsb pdb:6D6I|reactome:R-HSA-168638|reactome:R-HSA-168927|reactome:R-HSA-202424|reactome:R-HSA-2871837|reactome:R-HSA-445989|reactome:R-HSA-450302|reactome:R-HSA-450321|reactome:R-HSA-5607764|reactome:R-HSA-9020702|reactome:R-HSA-937039|reactome:R-HSA-937041|reactome:R-HSA-9646399|reactome:R-HSA-975110|reactome:R-HSA-975144|reactome:R-HSA-983168|dip:DIP-41911N	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S3|resulting-ptm:Q9Y5K5 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:EwhjYjowkZIAt4UyPcZBUtf9uak10116	rogid:x95N7Dj2KIqu5gySX59xLmfthUg9606	intact-crc:EABA6883F8D843A7|rigid:Zrjif24i1XDX75N2dLJg3Az/m2I	false	sufficient binding region:433-481(IPR013083)	his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q62925	uniprotkb:P22314	intact:EBI-636664	intact:EBI-709688|uniprotkb:Q96E13|uniprotkb:Q5JRR8|ensembl:ENSP00000338413|ensembl:ENSP00000366568	psi-mi:m3k1_rat(display_long)|uniprotkb:MAPK/ERK kinase kinase 1(gene name synonym)|uniprotkb:Map3k1(gene name)|psi-mi:Map3k1(display_short)|uniprotkb:Mekk(gene name synonym)|uniprotkb:Mekk1(gene name synonym)	psi-mi:uba1_human(display_long)|uniprotkb:Ubiquitin-activating enzyme E1(gene name synonym)|uniprotkb:Protein A1S9(gene name synonym)|uniprotkb:UBA1(gene name)|psi-mi:UBA1(display_short)|uniprotkb:A1S9T(gene name synonym)|uniprotkb:UBE1(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9973064|imex:IM-22822-136	author-confidence:Z-score = 6.27	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:620966|refseq:NP_446339.1|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR007527(Zinc finger, SWIM-type)|go:"GO:0000165"(MAPK cascade)|interpro:IPR016024(Armadillo-type fold)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0002011"(morphogenesis of an epithelial sheet)|go:"GO:0003382"(epithelial cell morphogenesis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004706"(JUN kinase kinase kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007254"(JNK cascade)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008432"(JUN kinase binding)|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0016020"(membrane)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0031434"(mitogen-activated protein kinase kinase binding)|go:"GO:0031941"(filamentous actin)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0042060"(wound healing)|go:"GO:0043010"(camera-type eye development)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046625"(sphingolipid binding)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050434"(positive regulation of viral transcription)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0061029"(eyelid development in camera-type eye)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|reactome:R-RNO-166058|reactome:R-RNO-2871796|reactome:R-RNO-975138|reactome:R-RNO-975871|interpro:IPR011989(Armadillo-like helical)|mint:Q62925	refseq:NP_003325.2|refseq:NP_695012.1|refseq:XP_016885269.1|refseq:XP_016885270.1|dip:DIP-33686N|ensembl:ENSG00000130985(gene)|ensembl:ENST00000335972(transcript)|ensembl:ENST00000377351(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0004839"(ubiquitin activating enzyme activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0032446"(protein modification by small protein conjugation)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000011(Ubiquitin-activating enzyme, E1)|interpro:IPR000594(UBA/THIF-type NAD/FAD binding fold)|interpro:IPR018074|interpro:IPR018075|interpro:IPR018965|interpro:IPR019572|interpro:IPR032418|interpro:IPR032420|interpro:IPR033127|interpro:IPR035985|interpro:IPR038252|interpro:IPR042063|interpro:IPR042302|interpro:IPR042449|mint:P22314|rcsb pdb:4P22|rcsb pdb:6DC6|reactome:R-HSA-8866652|reactome:R-HSA-983168	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S3|resulting-ptm:Q9Y5K5 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:EwhjYjowkZIAt4UyPcZBUtf9uak10116	rogid:q+vEeA0XLST0Zz173bmEt0dNbDE9606	intact-crc:EABA6883F8D843A7|rigid:Zrjif24i1XDX75N2dLJg3Az/m2I	false	sufficient binding region:433-481(IPR013083)	his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q62925	uniprotkb:P61088	intact:EBI-636664	intact:EBI-1052908|uniprotkb:Q16781|uniprotkb:Q53Y81|ensembl:ENSP00000316176	psi-mi:m3k1_rat(display_long)|uniprotkb:MAPK/ERK kinase kinase 1(gene name synonym)|uniprotkb:Map3k1(gene name)|psi-mi:Map3k1(display_short)|uniprotkb:Mekk(gene name synonym)|uniprotkb:Mekk1(gene name synonym)	psi-mi:ube2n_human(display_long)|uniprotkb:Ubiquitin-protein ligase N(gene name synonym)|uniprotkb:Ubiquitin carrier protein N(gene name synonym)|uniprotkb:Ubc13(gene name synonym)|uniprotkb:Bendless-like ubiquitin-conjugating enzyme(gene name synonym)|uniprotkb:UBE2N(gene name)|psi-mi:UBE2N(display_short)|uniprotkb:BLU(gene name synonym)|uniprotkb:UbcH13(gene name synonym)|uniprotkb:E2 ubiquitin-conjugating enzyme N(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9973064|imex:IM-22822-136	author-confidence:Z-score = 6.27	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:620966|refseq:NP_446339.1|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR007527(Zinc finger, SWIM-type)|go:"GO:0000165"(MAPK cascade)|interpro:IPR016024(Armadillo-type fold)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0002011"(morphogenesis of an epithelial sheet)|go:"GO:0003382"(epithelial cell morphogenesis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004706"(JUN kinase kinase kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007254"(JNK cascade)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008432"(JUN kinase binding)|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0016020"(membrane)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0031434"(mitogen-activated protein kinase kinase binding)|go:"GO:0031941"(filamentous actin)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0042060"(wound healing)|go:"GO:0043010"(camera-type eye development)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046625"(sphingolipid binding)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050434"(positive regulation of viral transcription)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0061029"(eyelid development in camera-type eye)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|reactome:R-RNO-166058|reactome:R-RNO-2871796|reactome:R-RNO-975138|reactome:R-RNO-975871|interpro:IPR011989(Armadillo-like helical)|mint:Q62925	refseq:NP_003339.1|dip:DIP-29829N|ensembl:ENSG00000177889(gene)|ensembl:ENST00000318066(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000729"(DNA double-strand break processing)|go:"GO:0001650"(fibrillar center)|go:"GO:0003723"(RNA binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006282"(regulation of DNA repair)|go:"GO:0006301"(postreplication repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016574"(histone ubiquitination)|go:"GO:0031058"(positive regulation of histone modification)|go:"GO:0031372"(UBC13-MMS2 complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033182"(regulation of histone ubiquitination)|go:"GO:0035370"(UBC13-UEV1A complex)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0061631"(ubiquitin conjugating enzyme activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070534"(protein K63-linked ubiquitination)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|interpro:IPR023313|rcsb pdb:1J7D|rcsb pdb:2C2V|rcsb pdb:3HCT|rcsb pdb:3HCU|rcsb pdb:3VON|rcsb pdb:3W31|rcsb pdb:4DHI|rcsb pdb:4DHJ|rcsb pdb:4DHZ|rcsb pdb:4IP3|rcsb pdb:4NR3|rcsb pdb:4NRG|rcsb pdb:4NRI|rcsb pdb:4ONL|rcsb pdb:4ONM|rcsb pdb:4ONN|rcsb pdb:4ORH|rcsb pdb:4TKP|rcsb pdb:4WHV|rcsb pdb:5AIT|rcsb pdb:5AIU|rcsb pdb:5EYA|rcsb pdb:5H7S|rcsb pdb:5VNZ|rcsb pdb:5VO0|rcsb pdb:5YWR|rcsb pdb:6D6I|rcsb pdb:6JKY|rcsb pdb:6KFP|rcsb pdb:6KG6|rcsb pdb:6KL4|rcsb pdb:6LP2|rcsb pdb:6P5B|rcsb pdb:6S53|reactome:R-HSA-168927|reactome:R-HSA-202424|reactome:R-HSA-2871837|reactome:R-HSA-445989|reactome:R-HSA-450302|reactome:R-HSA-450321|reactome:R-HSA-5607764|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-5696395|reactome:R-HSA-69473|reactome:R-HSA-8866654|reactome:R-HSA-9020702|reactome:R-HSA-937039|reactome:R-HSA-937041|reactome:R-HSA-9646399|reactome:R-HSA-975110|reactome:R-HSA-975144|reactome:R-HSA-983168|rcsb pdb:6ULH|rcsb pdb:6UMP|rcsb pdb:6UMS|rcsb pdb:7BBD|rcsb pdb:7BBF|rcsb pdb:7BXG|reactome:R-HSA-1169408|reactome:R-HSA-168638	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S3|resulting-ptm:Q9Y5K5 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:EwhjYjowkZIAt4UyPcZBUtf9uak10116	rogid:dqdszHlq5FLPHC6UWX6uvkC6Yz89606	intact-crc:EABA6883F8D843A7|rigid:Zrjif24i1XDX75N2dLJg3Az/m2I	false	sufficient binding region:433-481(IPR013083)	his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q62925	uniprotkb:Q9Y5K5	intact:EBI-636664	intact:EBI-1051183|uniprotkb:Q5LJA6|uniprotkb:Q5LJA7|uniprotkb:Q8TBS4|uniprotkb:Q96BJ9|uniprotkb:Q9H1W5|uniprotkb:Q9P0I3|uniprotkb:Q9UQN2|ensembl:ENSP00000356425	psi-mi:m3k1_rat(display_long)|uniprotkb:MAPK/ERK kinase kinase 1(gene name synonym)|uniprotkb:Map3k1(gene name)|psi-mi:Map3k1(display_short)|uniprotkb:Mekk(gene name synonym)|uniprotkb:Mekk1(gene name synonym)	psi-mi:uchl5_human(display_long)|uniprotkb:Ubiquitin thioesterase L5(gene name synonym)|uniprotkb:Ubiquitin C-terminal hydrolase UCH37(gene name synonym)|uniprotkb:UCHL5(gene name)|psi-mi:UCHL5(display_short)|uniprotkb:UCH37(gene name synonym)|uniprotkb:AD-019(orf name)|uniprotkb:CGI-70(orf name)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9973064|imex:IM-22822-136	author-confidence:Z-score = 6.27	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:620966|refseq:NP_446339.1|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR007527(Zinc finger, SWIM-type)|go:"GO:0000165"(MAPK cascade)|interpro:IPR016024(Armadillo-type fold)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0002011"(morphogenesis of an epithelial sheet)|go:"GO:0003382"(epithelial cell morphogenesis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004706"(JUN kinase kinase kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007254"(JNK cascade)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008432"(JUN kinase binding)|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0016020"(membrane)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0031434"(mitogen-activated protein kinase kinase binding)|go:"GO:0031941"(filamentous actin)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0042060"(wound healing)|go:"GO:0043010"(camera-type eye development)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046625"(sphingolipid binding)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050434"(positive regulation of viral transcription)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0061029"(eyelid development in camera-type eye)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|reactome:R-RNO-166058|reactome:R-RNO-2871796|reactome:R-RNO-975138|reactome:R-RNO-975871|interpro:IPR011989(Armadillo-like helical)|mint:Q62925	refseq:NP_001186190.1|refseq:NP_001186191.1|refseq:NP_001186192.1|refseq:NP_057068.1|ensembl:ENSG00000116750(gene)|ensembl:ENST00000367455(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0004866"(endopeptidase inhibitor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0006310"(DNA recombination)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0021670"(lateral ventricle development)|go:"GO:0030901"(midbrain development)|go:"GO:0031011"(Ino80 complex)|go:"GO:0031597"(cytosolic proteasome complex)|go:"GO:0032435"(negative regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0045880"(positive regulation of smoothened signaling pathway)|go:"GO:0048853"(forebrain morphogenesis)|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0070628"(proteasome binding)|interpro:IPR001578(Peptidase C12, ubiquitin carboxyl-terminal hydrolase 1)|interpro:IPR017390(Ubiquitinyl hydrolase, UCH37 type)|interpro:IPR033837|interpro:IPR036959|interpro:IPR038765|interpro:IPR041507|mint:Q9Y5K5|rcsb pdb:3A7S|rcsb pdb:3IHR|rcsb pdb:3RII|rcsb pdb:3RIS|rcsb pdb:3TB3|rcsb pdb:4UEL|rcsb pdb:4UEM|rcsb pdb:4UF5|rcsb pdb:4UF6|rcsb pdb:4WLP|reactome:R-HSA-2173788|reactome:R-HSA-5689603|dip:DIP-42671N	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S3|resulting-ptm:Q9Y5K5 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:EwhjYjowkZIAt4UyPcZBUtf9uak10116	rogid:gRm5ttq5Tc0cBIOQ1ut2ugzbMTY9606	intact-crc:EABA6883F8D843A7|rigid:Zrjif24i1XDX75N2dLJg3Az/m2I	false	sufficient binding region:433-481(IPR013083)	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9Y6I3	uniprotkb:Q62925	intact:EBI-713198|intact:EBI-28967658|ensembl:ENSP00000270460|uniprotkb:Q86ST3|uniprotkb:Q9HA18	intact:EBI-636664	psi-mi:epn1_human(display_long)|uniprotkb:EPS-15-interacting protein 1(gene name synonym)|uniprotkb:EH domain-binding mitotic phosphoprotein(gene name synonym)|uniprotkb:EPN1(gene name)|psi-mi:EPN1(display_short)	psi-mi:m3k1_rat(display_long)|uniprotkb:MAPK/ERK kinase kinase 1(gene name synonym)|uniprotkb:Map3k1(gene name)|psi-mi:Map3k1(display_short)|uniprotkb:Mekk(gene name synonym)|uniprotkb:Mekk1(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9973089|imex:IM-22822-137	author-confidence:Z-score = 6.54	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006897"(endocytosis)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0007565"(female pregnancy)|go:"GO:0030125"(clathrin vesicle coat)|go:"GO:0030276"(clathrin binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0048568"(embryonic organ development)|go:"GO:1903671"(negative regulation of sprouting angiogenesis)|interpro:IPR003903(Ubiquitin interacting motif)|interpro:IPR008942(ENTH/VHS)|interpro:IPR013809(Epsin-like, N-terminal)|mint:Q9Y6I3|rcsb pdb:1INZ|rcsb pdb:1KYD|reactome:R-HSA-182971|reactome:R-HSA-8856825|reactome:R-HSA-8856828|ensembl:ENSG00000063245(gene)|ensembl:ENST00000270460(transcript)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005634"(nucleus)|go:"GO:0005768"(endosome)|ensembl:ENST00000085079|ensembl:ENSP00000085079|ensembl:ENSP00000270460|ensembl:ENST00000411543|ensembl:ENSP00000406209|refseq:NP_001123543.1|refseq:NP_001123544.1|refseq:NP_037465.2|refseq:XP_005258886.1|refseq:XP_016882211.1|refseq:XP_011525183.1	rgd:620966|refseq:NP_446339.1|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR007527(Zinc finger, SWIM-type)|go:"GO:0000165"(MAPK cascade)|interpro:IPR016024(Armadillo-type fold)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0002011"(morphogenesis of an epithelial sheet)|go:"GO:0003382"(epithelial cell morphogenesis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004706"(JUN kinase kinase kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007254"(JNK cascade)|go:"GO:0007256"(obsolete activation of JNKK activity)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008432"(JUN kinase binding)|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0016020"(membrane)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0031434"(mitogen-activated protein kinase kinase binding)|go:"GO:0031941"(filamentous actin)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0042060"(wound healing)|go:"GO:0043010"(camera-type eye development)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046625"(sphingolipid binding)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0050434"(positive regulation of viral transcription)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0061029"(eyelid development in camera-type eye)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|reactome:R-RNO-166058|reactome:R-RNO-2871796|reactome:R-RNO-975138|reactome:R-RNO-975871|interpro:IPR011989(Armadillo-like helical)|mint:Q62925	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S3|resulting-ptm:Q9Y6I3 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:mp6MIJYGUJryy3Lk5coFqvOt55c9606	rogid:EwhjYjowkZIAt4UyPcZBUtf9uak10116	intact-crc:102841CFAC3A593C|rigid:ujeMK3//jA++S26eRz2q8r+Wlfw	false	-	sufficient binding region:433-481(IPR013083)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9Y6I3	uniprotkb:Q13404	intact:EBI-713198|intact:EBI-28967658|ensembl:ENSP00000270460|uniprotkb:Q86ST3|uniprotkb:Q9HA18	intact:EBI-1050671|uniprotkb:Q13403|uniprotkb:Q13532|uniprotkb:Q96H34|uniprotkb:Q9GZT0|uniprotkb:Q9GZW1|uniprotkb:Q9H4J3|uniprotkb:Q9H4J4|uniprotkb:Q9UKL1|uniprotkb:Q9UM48|uniprotkb:Q9UM49|uniprotkb:Q9UM50|uniprotkb:Q5TGE3|uniprotkb:E1P629|uniprotkb:Q5TGE0|ensembl:ENSP00000360739	psi-mi:epn1_human(display_long)|uniprotkb:EPS-15-interacting protein 1(gene name synonym)|uniprotkb:EH domain-binding mitotic phosphoprotein(gene name synonym)|uniprotkb:EPN1(gene name)|psi-mi:EPN1(display_short)	psi-mi:ub2v1_human(display_long)|uniprotkb:CROC-1(gene name synonym)|uniprotkb:TRAF6-regulated IKK activator 1 beta Uev1A(gene name synonym)|uniprotkb:P/OKcl.19(orf name)|uniprotkb:UBE2V1(gene name)|psi-mi:UBE2V1(display_short)|uniprotkb:CROC1(gene name synonym)|uniprotkb:UBE2V(gene name synonym)|uniprotkb:UEV1(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9973089|imex:IM-22822-137	author-confidence:Z-score = 6.54	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006897"(endocytosis)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0007565"(female pregnancy)|go:"GO:0030125"(clathrin vesicle coat)|go:"GO:0030276"(clathrin binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0048568"(embryonic organ development)|go:"GO:1903671"(negative regulation of sprouting angiogenesis)|interpro:IPR003903(Ubiquitin interacting motif)|interpro:IPR008942(ENTH/VHS)|interpro:IPR013809(Epsin-like, N-terminal)|mint:Q9Y6I3|rcsb pdb:1INZ|rcsb pdb:1KYD|reactome:R-HSA-182971|reactome:R-HSA-8856825|reactome:R-HSA-8856828|ensembl:ENSG00000063245(gene)|ensembl:ENST00000270460(transcript)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005634"(nucleus)|go:"GO:0005768"(endosome)|ensembl:ENST00000085079|ensembl:ENSP00000085079|ensembl:ENSP00000270460|ensembl:ENST00000411543|ensembl:ENSP00000406209|refseq:NP_001123543.1|refseq:NP_001123544.1|refseq:NP_037465.2|refseq:XP_005258886.1|refseq:XP_016882211.1|refseq:XP_011525183.1	refseq:NP_001027459.1|refseq:NP_068823.2|refseq:NP_071887.1|refseq:NP_954595.1|refseq:NP_954673.1|refseq:NP_001244322.1|refseq:NP_001244323.1|refseq:NP_001244325.1|ensembl:ENSG00000244687(gene)|ensembl:ENST00000371674(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006282"(regulation of DNA repair)|go:"GO:0006301"(postreplication repair)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0030154"(cell differentiation)|go:"GO:0031371"(ubiquitin conjugating enzyme complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035370"(UBC13-UEV1A complex)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070534"(protein K63-linked ubiquitination)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|rcsb pdb:2A4D|rcsb pdb:2C2V|rcsb pdb:2HLW|rcsb pdb:6D6I|reactome:R-HSA-168638|reactome:R-HSA-168927|reactome:R-HSA-202424|reactome:R-HSA-2871837|reactome:R-HSA-445989|reactome:R-HSA-450302|reactome:R-HSA-450321|reactome:R-HSA-5607764|reactome:R-HSA-9020702|reactome:R-HSA-937039|reactome:R-HSA-937041|reactome:R-HSA-9646399|reactome:R-HSA-975110|reactome:R-HSA-975144|reactome:R-HSA-983168|dip:DIP-41911N	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S3|resulting-ptm:Q9Y6I3 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:mp6MIJYGUJryy3Lk5coFqvOt55c9606	rogid:x95N7Dj2KIqu5gySX59xLmfthUg9606	intact-crc:102841CFAC3A593C|rigid:ujeMK3//jA++S26eRz2q8r+Wlfw	false	-	his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9Y6I3	uniprotkb:P22314	intact:EBI-713198|intact:EBI-28967658|ensembl:ENSP00000270460|uniprotkb:Q86ST3|uniprotkb:Q9HA18	intact:EBI-709688|uniprotkb:Q96E13|uniprotkb:Q5JRR8|ensembl:ENSP00000338413|ensembl:ENSP00000366568	psi-mi:epn1_human(display_long)|uniprotkb:EPS-15-interacting protein 1(gene name synonym)|uniprotkb:EH domain-binding mitotic phosphoprotein(gene name synonym)|uniprotkb:EPN1(gene name)|psi-mi:EPN1(display_short)	psi-mi:uba1_human(display_long)|uniprotkb:Ubiquitin-activating enzyme E1(gene name synonym)|uniprotkb:Protein A1S9(gene name synonym)|uniprotkb:UBA1(gene name)|psi-mi:UBA1(display_short)|uniprotkb:A1S9T(gene name synonym)|uniprotkb:UBE1(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9973089|imex:IM-22822-137	author-confidence:Z-score = 6.54	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006897"(endocytosis)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0007565"(female pregnancy)|go:"GO:0030125"(clathrin vesicle coat)|go:"GO:0030276"(clathrin binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0048568"(embryonic organ development)|go:"GO:1903671"(negative regulation of sprouting angiogenesis)|interpro:IPR003903(Ubiquitin interacting motif)|interpro:IPR008942(ENTH/VHS)|interpro:IPR013809(Epsin-like, N-terminal)|mint:Q9Y6I3|rcsb pdb:1INZ|rcsb pdb:1KYD|reactome:R-HSA-182971|reactome:R-HSA-8856825|reactome:R-HSA-8856828|ensembl:ENSG00000063245(gene)|ensembl:ENST00000270460(transcript)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005634"(nucleus)|go:"GO:0005768"(endosome)|ensembl:ENST00000085079|ensembl:ENSP00000085079|ensembl:ENSP00000270460|ensembl:ENST00000411543|ensembl:ENSP00000406209|refseq:NP_001123543.1|refseq:NP_001123544.1|refseq:NP_037465.2|refseq:XP_005258886.1|refseq:XP_016882211.1|refseq:XP_011525183.1	refseq:NP_003325.2|refseq:NP_695012.1|refseq:XP_016885269.1|refseq:XP_016885270.1|dip:DIP-33686N|ensembl:ENSG00000130985(gene)|ensembl:ENST00000335972(transcript)|ensembl:ENST00000377351(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0004839"(ubiquitin activating enzyme activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0032446"(protein modification by small protein conjugation)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000011(Ubiquitin-activating enzyme, E1)|interpro:IPR000594(UBA/THIF-type NAD/FAD binding fold)|interpro:IPR018074|interpro:IPR018075|interpro:IPR018965|interpro:IPR019572|interpro:IPR032418|interpro:IPR032420|interpro:IPR033127|interpro:IPR035985|interpro:IPR038252|interpro:IPR042063|interpro:IPR042302|interpro:IPR042449|mint:P22314|rcsb pdb:4P22|rcsb pdb:6DC6|reactome:R-HSA-8866652|reactome:R-HSA-983168	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S3|resulting-ptm:Q9Y6I3 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:mp6MIJYGUJryy3Lk5coFqvOt55c9606	rogid:q+vEeA0XLST0Zz173bmEt0dNbDE9606	intact-crc:102841CFAC3A593C|rigid:ujeMK3//jA++S26eRz2q8r+Wlfw	false	-	his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9Y6I3	uniprotkb:P61088	intact:EBI-713198|intact:EBI-28967658|ensembl:ENSP00000270460|uniprotkb:Q86ST3|uniprotkb:Q9HA18	intact:EBI-1052908|uniprotkb:Q16781|uniprotkb:Q53Y81|ensembl:ENSP00000316176	psi-mi:epn1_human(display_long)|uniprotkb:EPS-15-interacting protein 1(gene name synonym)|uniprotkb:EH domain-binding mitotic phosphoprotein(gene name synonym)|uniprotkb:EPN1(gene name)|psi-mi:EPN1(display_short)	psi-mi:ube2n_human(display_long)|uniprotkb:Ubiquitin-protein ligase N(gene name synonym)|uniprotkb:Ubiquitin carrier protein N(gene name synonym)|uniprotkb:Ubc13(gene name synonym)|uniprotkb:Bendless-like ubiquitin-conjugating enzyme(gene name synonym)|uniprotkb:UBE2N(gene name)|psi-mi:UBE2N(display_short)|uniprotkb:BLU(gene name synonym)|uniprotkb:UbcH13(gene name synonym)|uniprotkb:E2 ubiquitin-conjugating enzyme N(gene name synonym)	psi-mi:"MI:0997"(ubiquitinase assay)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9973089|imex:IM-22822-137	author-confidence:Z-score = 6.54	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006897"(endocytosis)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0007565"(female pregnancy)|go:"GO:0030125"(clathrin vesicle coat)|go:"GO:0030276"(clathrin binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0048568"(embryonic organ development)|go:"GO:1903671"(negative regulation of sprouting angiogenesis)|interpro:IPR003903(Ubiquitin interacting motif)|interpro:IPR008942(ENTH/VHS)|interpro:IPR013809(Epsin-like, N-terminal)|mint:Q9Y6I3|rcsb pdb:1INZ|rcsb pdb:1KYD|reactome:R-HSA-182971|reactome:R-HSA-8856825|reactome:R-HSA-8856828|ensembl:ENSG00000063245(gene)|ensembl:ENST00000270460(transcript)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005634"(nucleus)|go:"GO:0005768"(endosome)|ensembl:ENST00000085079|ensembl:ENSP00000085079|ensembl:ENSP00000270460|ensembl:ENST00000411543|ensembl:ENSP00000406209|refseq:NP_001123543.1|refseq:NP_001123544.1|refseq:NP_037465.2|refseq:XP_005258886.1|refseq:XP_016882211.1|refseq:XP_011525183.1	refseq:NP_003339.1|dip:DIP-29829N|ensembl:ENSG00000177889(gene)|ensembl:ENST00000318066(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000729"(DNA double-strand break processing)|go:"GO:0001650"(fibrillar center)|go:"GO:0003723"(RNA binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006282"(regulation of DNA repair)|go:"GO:0006301"(postreplication repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016574"(histone ubiquitination)|go:"GO:0031058"(positive regulation of histone modification)|go:"GO:0031372"(UBC13-MMS2 complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033182"(regulation of histone ubiquitination)|go:"GO:0035370"(UBC13-UEV1A complex)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0061631"(ubiquitin conjugating enzyme activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070534"(protein K63-linked ubiquitination)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|interpro:IPR023313|rcsb pdb:1J7D|rcsb pdb:2C2V|rcsb pdb:3HCT|rcsb pdb:3HCU|rcsb pdb:3VON|rcsb pdb:3W31|rcsb pdb:4DHI|rcsb pdb:4DHJ|rcsb pdb:4DHZ|rcsb pdb:4IP3|rcsb pdb:4NR3|rcsb pdb:4NRG|rcsb pdb:4NRI|rcsb pdb:4ONL|rcsb pdb:4ONM|rcsb pdb:4ONN|rcsb pdb:4ORH|rcsb pdb:4TKP|rcsb pdb:4WHV|rcsb pdb:5AIT|rcsb pdb:5AIU|rcsb pdb:5EYA|rcsb pdb:5H7S|rcsb pdb:5VNZ|rcsb pdb:5VO0|rcsb pdb:5YWR|rcsb pdb:6D6I|rcsb pdb:6JKY|rcsb pdb:6KFP|rcsb pdb:6KG6|rcsb pdb:6KL4|rcsb pdb:6LP2|rcsb pdb:6P5B|rcsb pdb:6S53|reactome:R-HSA-168927|reactome:R-HSA-202424|reactome:R-HSA-2871837|reactome:R-HSA-445989|reactome:R-HSA-450302|reactome:R-HSA-450321|reactome:R-HSA-5607764|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-5696395|reactome:R-HSA-69473|reactome:R-HSA-8866654|reactome:R-HSA-9020702|reactome:R-HSA-937039|reactome:R-HSA-937041|reactome:R-HSA-9646399|reactome:R-HSA-975110|reactome:R-HSA-975144|reactome:R-HSA-983168|rcsb pdb:6ULH|rcsb pdb:6UMP|rcsb pdb:6UMS|rcsb pdb:7BBD|rcsb pdb:7BBF|rcsb pdb:7BXG|reactome:R-HSA-1169408|reactome:R-HSA-168638	go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0016567"(protein ubiquitination)	-	-	figure legend:Table S3|resulting-ptm:Q9Y6I3 ubiquitinylated lysine|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/27	2014/11/05	rogid:mp6MIJYGUJryy3Lk5coFqvOt55c9606	rogid:dqdszHlq5FLPHC6UWX6uvkC6Yz89606	intact-crc:102841CFAC3A593C|rigid:ujeMK3//jA++S26eRz2q8r+Wlfw	false	-	his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q8CF89	uniprotkb:P53349	intact:EBI-1778503|uniprotkb:Q7TQJ5|uniprotkb:Q80V65|uniprotkb:Q8R0D1|ensembl:ENSMUSP00000023050	intact:EBI-447913|uniprotkb:Q60831|uniprotkb:Q9R0U3|uniprotkb:Q9R256	psi-mi:tab1_mouse(display_long)|uniprotkb:Tab1(gene name)|psi-mi:Tab1(display_short)|uniprotkb:Map3k7ip1(gene name synonym)|uniprotkb:TGF-beta-activated kinase 1-binding protein 1(gene name synonym)|uniprotkb:Mitogen-activated protein kinase kinase kinase 7-interacting protein 1(gene name synonym)	psi-mi:m3k1_mouse(display_long)|uniprotkb:MAPK/ERK kinase kinase 1(gene name synonym)|uniprotkb:Map3k1(gene name)|psi-mi:Map3k1(display_short)|uniprotkb:Mekk(gene name synonym)|uniprotkb:Mekk1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9973128|imex:IM-22822-139	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_079885.2|ensembl:ENSMUSG00000022414(gene)|ensembl:ENSMUST00000023050(transcript)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0003279"(cardiac septum development)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0016607"(nuclear speck)|go:"GO:0016791"(phosphatase activity)|go:"GO:0019209"(kinase activator activity)|go:"GO:0030324"(lung development)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035904"(aorta development)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0048273"(mitogen-activated protein kinase p38 binding)|go:"GO:0060976"(coronary vasculature development)|interpro:IPR001932(Protein phosphatase 2C-related)|interpro:IPR015655(Protein phosphatase 2C)|interpro:IPR036457|mint:Q8CF89|rcsb pdb:4LOO|rcsb pdb:4LOP|rcsb pdb:4LOQ|reactome:R-MMU-168638|reactome:R-MMU-2871837|reactome:R-MMU-445989|reactome:R-MMU-450302|reactome:R-MMU-450321|reactome:R-MMU-5357956|reactome:R-MMU-5607764|reactome:R-MMU-5689880|reactome:R-MMU-9020702|reactome:R-MMU-937042|reactome:R-MMU-937072|reactome:R-MMU-9645460|reactome:R-MMU-975163	go:"GO:0002011"(morphogenesis of an epithelial sheet)|go:"GO:0003382"(epithelial cell morphogenesis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004706"(JUN kinase kinase kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007254"(JNK cascade)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008432"(JUN kinase binding)|dip:DIP-32487N|mint:P53349|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0016020"(membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030054"(cell junction)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031434"(mitogen-activated protein kinase kinase binding)|go:"GO:0031941"(filamentous actin)|go:"GO:0042060"(wound healing)|go:"GO:0043010"(camera-type eye development)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046625"(sphingolipid binding)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0061029"(eyelid development in camera-type eye)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR007527(Zinc finger, SWIM-type)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|reactome:R-MMU-166058|reactome:R-MMU-2871796|reactome:R-MMU-975138|reactome:R-MMU-975871|interpro:IPR000719(Protein kinase, core)	-	-	-	figure legend:S4H|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2014/06/27	2014/11/05	rogid:3/x6GPVcXE+UvI+pNiuMBkw70tM10090	rogid:DR/c3qeWhJ76oKsNMEVhcUPmpXE10090	intact-crc:2E665F6277706999|rigid:KqJzsBv9OIcHunUbb2RXrFYCPDI	false	mutation:294-294,319-319,335-335,350-350	myc tag:n-n	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q8CF89	uniprotkb:P53349	intact:EBI-1778503|uniprotkb:Q7TQJ5|uniprotkb:Q80V65|uniprotkb:Q8R0D1|ensembl:ENSMUSP00000023050	intact:EBI-447913|uniprotkb:Q60831|uniprotkb:Q9R0U3|uniprotkb:Q9R256	psi-mi:tab1_mouse(display_long)|uniprotkb:Tab1(gene name)|psi-mi:Tab1(display_short)|uniprotkb:Map3k7ip1(gene name synonym)|uniprotkb:TGF-beta-activated kinase 1-binding protein 1(gene name synonym)|uniprotkb:Mitogen-activated protein kinase kinase kinase 7-interacting protein 1(gene name synonym)	psi-mi:m3k1_mouse(display_long)|uniprotkb:MAPK/ERK kinase kinase 1(gene name synonym)|uniprotkb:Map3k1(gene name)|psi-mi:Map3k1(display_short)|uniprotkb:Mekk(gene name synonym)|uniprotkb:Mekk1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9973121|imex:IM-22822-138	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_079885.2|ensembl:ENSMUSG00000022414(gene)|ensembl:ENSMUST00000023050(transcript)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0003279"(cardiac septum development)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0016607"(nuclear speck)|go:"GO:0016791"(phosphatase activity)|go:"GO:0019209"(kinase activator activity)|go:"GO:0030324"(lung development)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035904"(aorta development)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0048273"(mitogen-activated protein kinase p38 binding)|go:"GO:0060976"(coronary vasculature development)|interpro:IPR001932(Protein phosphatase 2C-related)|interpro:IPR015655(Protein phosphatase 2C)|interpro:IPR036457|mint:Q8CF89|rcsb pdb:4LOO|rcsb pdb:4LOP|rcsb pdb:4LOQ|reactome:R-MMU-168638|reactome:R-MMU-2871837|reactome:R-MMU-445989|reactome:R-MMU-450302|reactome:R-MMU-450321|reactome:R-MMU-5357956|reactome:R-MMU-5607764|reactome:R-MMU-5689880|reactome:R-MMU-9020702|reactome:R-MMU-937042|reactome:R-MMU-937072|reactome:R-MMU-9645460|reactome:R-MMU-975163	go:"GO:0002011"(morphogenesis of an epithelial sheet)|go:"GO:0003382"(epithelial cell morphogenesis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004706"(JUN kinase kinase kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007254"(JNK cascade)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008432"(JUN kinase binding)|dip:DIP-32487N|mint:P53349|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0016020"(membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030054"(cell junction)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031434"(mitogen-activated protein kinase kinase binding)|go:"GO:0031941"(filamentous actin)|go:"GO:0042060"(wound healing)|go:"GO:0043010"(camera-type eye development)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046625"(sphingolipid binding)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0061029"(eyelid development in camera-type eye)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR007527(Zinc finger, SWIM-type)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|reactome:R-MMU-166058|reactome:R-MMU-2871796|reactome:R-MMU-975138|reactome:R-MMU-975871|interpro:IPR000719(Protein kinase, core)	-	-	-	figure legend:S4H|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2014/06/27	2014/11/05	rogid:3/x6GPVcXE+UvI+pNiuMBkw70tM10090	rogid:DR/c3qeWhJ76oKsNMEVhcUPmpXE10090	intact-crc:3A832638224D93A3|rigid:6WBeWjfQmbVlzgZ3VCTYaD/DBZA	false	-	myc tag:n-n	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q8CF89	uniprotkb:P49116	intact:EBI-1778503|uniprotkb:Q7TQJ5|uniprotkb:Q80V65|uniprotkb:Q8R0D1|ensembl:ENSMUSP00000023050	intact:EBI-2652582|uniprotkb:A8K3H5|uniprotkb:P55092|uniprotkb:B6ZGT8|ensembl:ENSP00000376814|ensembl:ENSP00000384463|ensembl:ENSP00000388387	psi-mi:tab1_mouse(display_long)|uniprotkb:Tab1(gene name)|psi-mi:Tab1(display_short)|uniprotkb:Map3k7ip1(gene name synonym)|uniprotkb:TGF-beta-activated kinase 1-binding protein 1(gene name synonym)|uniprotkb:Mitogen-activated protein kinase kinase kinase 7-interacting protein 1(gene name synonym)	psi-mi:nr2c2_human(display_long)|uniprotkb:NR2C2(gene name)|psi-mi:NR2C2(display_short)|uniprotkb:TAK1(gene name synonym)|uniprotkb:TR4(gene name synonym)|uniprotkb:Orphan nuclear receptor TR4(gene name synonym)|uniprotkb:Testicular receptor 4(gene name synonym)|uniprotkb:Orphan nuclear receptor TAK1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9973121|imex:IM-22822-138	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_079885.2|ensembl:ENSMUSG00000022414(gene)|ensembl:ENSMUST00000023050(transcript)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0003279"(cardiac septum development)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0016607"(nuclear speck)|go:"GO:0016791"(phosphatase activity)|go:"GO:0019209"(kinase activator activity)|go:"GO:0030324"(lung development)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035904"(aorta development)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0048273"(mitogen-activated protein kinase p38 binding)|go:"GO:0060976"(coronary vasculature development)|interpro:IPR001932(Protein phosphatase 2C-related)|interpro:IPR015655(Protein phosphatase 2C)|interpro:IPR036457|mint:Q8CF89|rcsb pdb:4LOO|rcsb pdb:4LOP|rcsb pdb:4LOQ|reactome:R-MMU-168638|reactome:R-MMU-2871837|reactome:R-MMU-445989|reactome:R-MMU-450302|reactome:R-MMU-450321|reactome:R-MMU-5357956|reactome:R-MMU-5607764|reactome:R-MMU-5689880|reactome:R-MMU-9020702|reactome:R-MMU-937042|reactome:R-MMU-937072|reactome:R-MMU-9645460|reactome:R-MMU-975163	refseq:NP_003289.2|refseq:NP_001278623.1|ensembl:ENSG00000177463(gene)|ensembl:ENST00000393102(transcript)|ensembl:ENST00000406272(transcript)|ensembl:ENST00000425241(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0004879"(nuclear receptor activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007399"(nervous system development)|go:"GO:0008270"(zinc ion binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0040019"(positive regulation of embryonic development)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048856"(anatomical structure development)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000536(Nuclear hormone receptor, ligand-binding, core)|interpro:IPR001628(Zinc finger, nuclear hormone receptor-type)|interpro:IPR001723(Steroid hormone receptor)|interpro:IPR013088(Zinc finger, NHR/GATA-type)|interpro:IPR035500|mint:P49116|rcsb pdb:3P0U|reactome:R-HSA-383280|refseq:XP_016862609.1|dip:DIP-5999N	-	-	-	figure legend:S4H|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2014/06/27	2014/11/05	rogid:3/x6GPVcXE+UvI+pNiuMBkw70tM10090	rogid:FQqhbuxItvCQ2iu5nydvHZaNog89606	intact-crc:3A832638224D93A3|rigid:6WBeWjfQmbVlzgZ3VCTYaD/DBZA	false	-	-	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q8CF89	uniprotkb:P53349	intact:EBI-1778503|uniprotkb:Q7TQJ5|uniprotkb:Q80V65|uniprotkb:Q8R0D1|ensembl:ENSMUSP00000023050	intact:EBI-447913|uniprotkb:Q60831|uniprotkb:Q9R0U3|uniprotkb:Q9R256	psi-mi:tab1_mouse(display_long)|uniprotkb:Tab1(gene name)|psi-mi:Tab1(display_short)|uniprotkb:Map3k7ip1(gene name synonym)|uniprotkb:TGF-beta-activated kinase 1-binding protein 1(gene name synonym)|uniprotkb:Mitogen-activated protein kinase kinase kinase 7-interacting protein 1(gene name synonym)	psi-mi:m3k1_mouse(display_long)|uniprotkb:MAPK/ERK kinase kinase 1(gene name synonym)|uniprotkb:Map3k1(gene name)|psi-mi:Map3k1(display_short)|uniprotkb:Mekk(gene name synonym)|uniprotkb:Mekk1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Charlaftis et al. (2014)	imex:IM-22822|pubmed:25260751	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9973163|imex:IM-22822-140	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_079885.2|ensembl:ENSMUSG00000022414(gene)|ensembl:ENSMUST00000023050(transcript)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0003279"(cardiac septum development)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0016607"(nuclear speck)|go:"GO:0016791"(phosphatase activity)|go:"GO:0019209"(kinase activator activity)|go:"GO:0030324"(lung development)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035904"(aorta development)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0048273"(mitogen-activated protein kinase p38 binding)|go:"GO:0060976"(coronary vasculature development)|interpro:IPR001932(Protein phosphatase 2C-related)|interpro:IPR015655(Protein phosphatase 2C)|interpro:IPR036457|mint:Q8CF89|rcsb pdb:4LOO|rcsb pdb:4LOP|rcsb pdb:4LOQ|reactome:R-MMU-168638|reactome:R-MMU-2871837|reactome:R-MMU-445989|reactome:R-MMU-450302|reactome:R-MMU-450321|reactome:R-MMU-5357956|reactome:R-MMU-5607764|reactome:R-MMU-5689880|reactome:R-MMU-9020702|reactome:R-MMU-937042|reactome:R-MMU-937072|reactome:R-MMU-9645460|reactome:R-MMU-975163	go:"GO:0002011"(morphogenesis of an epithelial sheet)|go:"GO:0003382"(epithelial cell morphogenesis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004706"(JUN kinase kinase kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007254"(JNK cascade)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008432"(JUN kinase binding)|dip:DIP-32487N|mint:P53349|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0016020"(membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030054"(cell junction)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031434"(mitogen-activated protein kinase kinase binding)|go:"GO:0031941"(filamentous actin)|go:"GO:0042060"(wound healing)|go:"GO:0043010"(camera-type eye development)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046625"(sphingolipid binding)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0061029"(eyelid development in camera-type eye)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR007527(Zinc finger, SWIM-type)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|reactome:R-MMU-166058|reactome:R-MMU-2871796|reactome:R-MMU-975138|reactome:R-MMU-975871|interpro:IPR000719(Protein kinase, core)	-	-	-	figure legend:S4I|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-embryonic_stem cell)|taxid:10090(Mus musculus embryonic stem cell)	-	2014/06/27	2014/11/06	rogid:3/x6GPVcXE+UvI+pNiuMBkw70tM10090	rogid:DR/c3qeWhJ76oKsNMEVhcUPmpXE10090	intact-crc:8D358E7C771C5C81|rigid:KqJzsBv9OIcHunUbb2RXrFYCPDI	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)