#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:Q9Y2R2 uniprotkb:O43586 intact:EBI-1211241|uniprotkb:A0N0K6|intact:EBI-28975949|uniprotkb:O95063|uniprotkb:O95064|uniprotkb:D4NZ71|uniprotkb:Q6IPX8|uniprotkb:Q8WVM1|uniprotkb:B1ALC8|uniprotkb:E9PLD8|uniprotkb:E9PPI1 intact:EBI-1050964|uniprotkb:O43585|uniprotkb:O95657|uniprotkb:B5BUK4|uniprotkb:B5BU74|ensembl:ENSP00000452746 psi-mi:ptn22_human(display_long)|uniprotkb:PTPN22(gene name)|psi-mi:PTPN22(display_short)|uniprotkb:PTPN8(gene name synonym)|uniprotkb:Hematopoietic cell protein-tyrosine phosphatase 70Z-PEP(gene name synonym)|uniprotkb:Lymphoid phosphatase(gene name synonym)|uniprotkb:PEST-domain phosphatase(gene name synonym) psi-mi:ppip1_human(display_long)|uniprotkb:CD2-binding protein 1(gene name synonym)|uniprotkb:H-PIP(gene name synonym)|uniprotkb:PSTPIP1(gene name)|psi-mi:PSTPIP1(display_short)|uniprotkb:CD2BP1(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Marcos et al. (2014) imex:IM-23065|pubmed:25040622 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-9635611|imex:IM-23065-1 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001180360.1|refseq:NP_036543.4|refseq:NP_057051.3|ensembl:ENST00000460620|ensembl:ENSP00000433141|ensembl:ENSG00000134242|refseq:NP_001295226.1|mint:Q9Y2R2|dip:DIP-29953N|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0004726"(non-membrane spanning protein tyrosine phosphatase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0006914"(autophagy)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016791"(phosphatase activity)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019900"(kinase binding)|go:"GO:0030217"(T cell differentiation)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032481"(positive regulation of type I interferon production)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032717"(negative regulation of interleukin-8 production)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032817"(regulation of natural killer cell proliferation)|go:"GO:0034141"(positive regulation of toll-like receptor 3 signaling pathway)|go:"GO:0034145"(positive regulation of toll-like receptor 4 signaling pathway)|go:"GO:0034157"(positive regulation of toll-like receptor 7 signaling pathway)|go:"GO:0034165"(positive regulation of toll-like receptor 9 signaling pathway)|go:"GO:0035335"(peptidyl-tyrosine dephosphorylation)|go:"GO:0035644"(phosphoanandamide dephosphorylation)|go:"GO:0043508"(negative regulation of JUN kinase activity)|go:"GO:0045088"(regulation of innate immune response)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0050855"(regulation of B cell receptor signaling pathway)|go:"GO:0050860"(negative regulation of T cell receptor signaling pathway)|go:"GO:0050868"(negative regulation of T cell activation)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070433"(negative regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway)|go:"GO:0071225"(cellular response to muramyl dipeptide)|go:"GO:0071663"(positive regulation of granzyme B production)|go:"GO:1901222"(regulation of NIK/NF-kappaB signaling)|go:"GO:1902523"(positive regulation of protein K63-linked ubiquitination)|go:"GO:1903753"(negative regulation of p38MAPK cascade)|go:"GO:2000566"(positive regulation of CD8-positive, alpha-beta T cell proliferation)|interpro:IPR000242(Protein-tyrosine phosphatase, receptor/non-receptor type)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR003595(Protein-tyrosine phosphatase, catalytic)|interpro:IPR016130(Protein-tyrosine phosphatase, active site)|interpro:IPR016276(Non-receptor tyrosine-protein phosphatase, 8/22)|interpro:IPR029021|rcsb pdb:2P6X|rcsb pdb:2QCJ|rcsb pdb:2QCT|rcsb pdb:3BRH|rcsb pdb:3H2X|rcsb pdb:3OLR|reactome:R-HSA-202430|rcsb pdb:3OMH|rcsb pdb:4J51|reactome:R-HSA-202427 refseq:NP_003969.2|refseq:NP_001308064.1|refseq:NP_001308066.1|ensembl:ENSG00000140368(gene)|ensembl:ENST00000558012(transcript)|go:"GO:0001931"(uropod)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0006897"(endocytosis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007155"(cell adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0016020"(membrane)|go:"GO:0030027"(lamellipodium)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0032154"(cleavage furrow)|go:"GO:0042802"(identical protein binding)|go:"GO:0045087"(innate immune response)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051015"(actin filament binding)|interpro:IPR001060(Cdc15/Fes/CIP4)|interpro:IPR001452(Src homology-3)|interpro:IPR027267|interpro:IPR030777|interpro:IPR031160|interpro:IPR036028|mint:O43586|rcsb pdb:2DIL|reactome:R-HSA-844456|reactome:R-HSA-9660826 - - - figure legend:f3b|comment:"we examined whether PSTPIP1 could bind to LYP by co-immunoprecipitation. PSTPIP1 was co-precipitated with LYP in PBLs and Jurkat cells (Figure 3B),"|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|dataset:IBD - Inflammatory bowel disease|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2014/06/30 2014/10/16 rogid:KyIn+zCiuuIacrwk5MUzPEUQqKQ9606 rogid:JWK4dCYdcVF6mKwe+hoOri1wwps9606 intact-crc:FFACD972358F9A5E|rigid:o1RSJu71e+plLYsVan+ZH96Yf3A false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:O43586 uniprotkb:Q9Y2R2 intact:EBI-1050964|uniprotkb:O43585|uniprotkb:O95657|uniprotkb:B5BUK4|uniprotkb:B5BU74|ensembl:ENSP00000452746 intact:EBI-1211241|uniprotkb:A0N0K6|intact:EBI-28975949|uniprotkb:O95063|uniprotkb:O95064|uniprotkb:D4NZ71|uniprotkb:Q6IPX8|uniprotkb:Q8WVM1|uniprotkb:B1ALC8|uniprotkb:E9PLD8|uniprotkb:E9PPI1 psi-mi:ppip1_human(display_long)|uniprotkb:CD2-binding protein 1(gene name synonym)|uniprotkb:H-PIP(gene name synonym)|uniprotkb:PSTPIP1(gene name)|psi-mi:PSTPIP1(display_short)|uniprotkb:CD2BP1(gene name synonym) psi-mi:ptn22_human(display_long)|uniprotkb:PTPN22(gene name)|psi-mi:PTPN22(display_short)|uniprotkb:PTPN8(gene name synonym)|uniprotkb:Hematopoietic cell protein-tyrosine phosphatase 70Z-PEP(gene name synonym)|uniprotkb:Lymphoid phosphatase(gene name synonym)|uniprotkb:PEST-domain phosphatase(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Marcos et al. (2014) imex:IM-23065|pubmed:25040622 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-9635653|imex:IM-23065-4 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_003969.2|refseq:NP_001308064.1|refseq:NP_001308066.1|ensembl:ENSG00000140368(gene)|ensembl:ENST00000558012(transcript)|go:"GO:0001931"(uropod)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0006897"(endocytosis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007155"(cell adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0016020"(membrane)|go:"GO:0030027"(lamellipodium)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0032154"(cleavage furrow)|go:"GO:0042802"(identical protein binding)|go:"GO:0045087"(innate immune response)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051015"(actin filament binding)|interpro:IPR001060(Cdc15/Fes/CIP4)|interpro:IPR001452(Src homology-3)|interpro:IPR027267|interpro:IPR030777|interpro:IPR031160|interpro:IPR036028|mint:O43586|rcsb pdb:2DIL|reactome:R-HSA-844456|reactome:R-HSA-9660826 refseq:NP_001180360.1|refseq:NP_036543.4|refseq:NP_057051.3|ensembl:ENST00000460620|ensembl:ENSP00000433141|ensembl:ENSG00000134242|refseq:NP_001295226.1|mint:Q9Y2R2|dip:DIP-29953N|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0004726"(non-membrane spanning protein tyrosine phosphatase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0006914"(autophagy)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016791"(phosphatase activity)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019900"(kinase binding)|go:"GO:0030217"(T cell differentiation)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032481"(positive regulation of type I interferon production)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032717"(negative regulation of interleukin-8 production)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032817"(regulation of natural killer cell proliferation)|go:"GO:0034141"(positive regulation of toll-like receptor 3 signaling pathway)|go:"GO:0034145"(positive regulation of toll-like receptor 4 signaling pathway)|go:"GO:0034157"(positive regulation of toll-like receptor 7 signaling pathway)|go:"GO:0034165"(positive regulation of toll-like receptor 9 signaling pathway)|go:"GO:0035335"(peptidyl-tyrosine dephosphorylation)|go:"GO:0035644"(phosphoanandamide dephosphorylation)|go:"GO:0043508"(negative regulation of JUN kinase activity)|go:"GO:0045088"(regulation of innate immune response)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0050855"(regulation of B cell receptor signaling pathway)|go:"GO:0050860"(negative regulation of T cell receptor signaling pathway)|go:"GO:0050868"(negative regulation of T cell activation)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070433"(negative regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway)|go:"GO:0071225"(cellular response to muramyl dipeptide)|go:"GO:0071663"(positive regulation of granzyme B production)|go:"GO:1901222"(regulation of NIK/NF-kappaB signaling)|go:"GO:1902523"(positive regulation of protein K63-linked ubiquitination)|go:"GO:1903753"(negative regulation of p38MAPK cascade)|go:"GO:2000566"(positive regulation of CD8-positive, alpha-beta T cell proliferation)|interpro:IPR000242(Protein-tyrosine phosphatase, receptor/non-receptor type)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR003595(Protein-tyrosine phosphatase, catalytic)|interpro:IPR016130(Protein-tyrosine phosphatase, active site)|interpro:IPR016276(Non-receptor tyrosine-protein phosphatase, 8/22)|interpro:IPR029021|rcsb pdb:2P6X|rcsb pdb:2QCJ|rcsb pdb:2QCT|rcsb pdb:3BRH|rcsb pdb:3H2X|rcsb pdb:3OLR|reactome:R-HSA-202430|rcsb pdb:3OMH|rcsb pdb:4J51|reactome:R-HSA-202427 - - - figure legend:f3e|comment:"we deleted the CTH motif from LYP and observed that this deletion abrogated LYP/PSTPIP1 interaction (Figure 3E). Additionally, in this experiment we tested whether the two variants of LYP, LYP-R and LYP-W, which is associated to several autoimmune diseases [20], bind to PSTPIP1 and no difference was observed (Figure 3E)."|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|dataset:IBD - Inflammatory bowel disease|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2014/06/30 2014/10/16 rogid:JWK4dCYdcVF6mKwe+hoOri1wwps9606 rogid:KyIn+zCiuuIacrwk5MUzPEUQqKQ9606 intact-crc:D46366799543E413|rigid:o1RSJu71e+plLYsVan+ZH96Yf3A false v5 tag:?-? ha tag:?-?|binding-associated region:796-804 - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:O43586 uniprotkb:Q9Y2R2 intact:EBI-1050964|uniprotkb:O43585|uniprotkb:O95657|uniprotkb:B5BUK4|uniprotkb:B5BU74|ensembl:ENSP00000452746 intact:EBI-1211241|uniprotkb:A0N0K6|intact:EBI-28975949|uniprotkb:O95063|uniprotkb:O95064|uniprotkb:D4NZ71|uniprotkb:Q6IPX8|uniprotkb:Q8WVM1|uniprotkb:B1ALC8|uniprotkb:E9PLD8|uniprotkb:E9PPI1 psi-mi:ppip1_human(display_long)|uniprotkb:CD2-binding protein 1(gene name synonym)|uniprotkb:H-PIP(gene name synonym)|uniprotkb:PSTPIP1(gene name)|psi-mi:PSTPIP1(display_short)|uniprotkb:CD2BP1(gene name synonym) psi-mi:ptn22_human(display_long)|uniprotkb:PTPN22(gene name)|psi-mi:PTPN22(display_short)|uniprotkb:PTPN8(gene name synonym)|uniprotkb:Hematopoietic cell protein-tyrosine phosphatase 70Z-PEP(gene name synonym)|uniprotkb:Lymphoid phosphatase(gene name synonym)|uniprotkb:PEST-domain phosphatase(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Marcos et al. (2014) imex:IM-23065|pubmed:25040622 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-9635624|imex:IM-23065-2 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_003969.2|refseq:NP_001308064.1|refseq:NP_001308066.1|ensembl:ENSG00000140368(gene)|ensembl:ENST00000558012(transcript)|go:"GO:0001931"(uropod)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0006897"(endocytosis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007155"(cell adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0016020"(membrane)|go:"GO:0030027"(lamellipodium)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0032154"(cleavage furrow)|go:"GO:0042802"(identical protein binding)|go:"GO:0045087"(innate immune response)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051015"(actin filament binding)|interpro:IPR001060(Cdc15/Fes/CIP4)|interpro:IPR001452(Src homology-3)|interpro:IPR027267|interpro:IPR030777|interpro:IPR031160|interpro:IPR036028|mint:O43586|rcsb pdb:2DIL|reactome:R-HSA-844456|reactome:R-HSA-9660826 refseq:NP_001180360.1|refseq:NP_036543.4|refseq:NP_057051.3|ensembl:ENST00000460620|ensembl:ENSP00000433141|ensembl:ENSG00000134242|refseq:NP_001295226.1|mint:Q9Y2R2|dip:DIP-29953N|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0004726"(non-membrane spanning protein tyrosine phosphatase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0006914"(autophagy)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016791"(phosphatase activity)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019900"(kinase binding)|go:"GO:0030217"(T cell differentiation)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032481"(positive regulation of type I interferon production)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032717"(negative regulation of interleukin-8 production)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032817"(regulation of natural killer cell proliferation)|go:"GO:0034141"(positive regulation of toll-like receptor 3 signaling pathway)|go:"GO:0034145"(positive regulation of toll-like receptor 4 signaling pathway)|go:"GO:0034157"(positive regulation of toll-like receptor 7 signaling pathway)|go:"GO:0034165"(positive regulation of toll-like receptor 9 signaling pathway)|go:"GO:0035335"(peptidyl-tyrosine dephosphorylation)|go:"GO:0035644"(phosphoanandamide dephosphorylation)|go:"GO:0043508"(negative regulation of JUN kinase activity)|go:"GO:0045088"(regulation of innate immune response)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0050855"(regulation of B cell receptor signaling pathway)|go:"GO:0050860"(negative regulation of T cell receptor signaling pathway)|go:"GO:0050868"(negative regulation of T cell activation)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070433"(negative regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway)|go:"GO:0071225"(cellular response to muramyl dipeptide)|go:"GO:0071663"(positive regulation of granzyme B production)|go:"GO:1901222"(regulation of NIK/NF-kappaB signaling)|go:"GO:1902523"(positive regulation of protein K63-linked ubiquitination)|go:"GO:1903753"(negative regulation of p38MAPK cascade)|go:"GO:2000566"(positive regulation of CD8-positive, alpha-beta T cell proliferation)|interpro:IPR000242(Protein-tyrosine phosphatase, receptor/non-receptor type)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR003595(Protein-tyrosine phosphatase, catalytic)|interpro:IPR016130(Protein-tyrosine phosphatase, active site)|interpro:IPR016276(Non-receptor tyrosine-protein phosphatase, 8/22)|interpro:IPR029021|rcsb pdb:2P6X|rcsb pdb:2QCJ|rcsb pdb:2QCT|rcsb pdb:3BRH|rcsb pdb:3H2X|rcsb pdb:3OLR|reactome:R-HSA-202430|rcsb pdb:3OMH|rcsb pdb:4J51|reactome:R-HSA-202427 - - - figure legend:f3c|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|dataset:IBD - Inflammatory bowel disease|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2014/06/30 2014/10/16 rogid:JWK4dCYdcVF6mKwe+hoOri1wwps9606 rogid:KyIn+zCiuuIacrwk5MUzPEUQqKQ9606 intact-crc:8E697B574FB0842A|rigid:o1RSJu71e+plLYsVan+ZH96Yf3A false binding-associated region:1-357|enhanced green fluorescent protein tag:?-? myc tag:?-? - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:O43586 uniprotkb:Q9Y2R2 intact:EBI-1050964|uniprotkb:O43585|uniprotkb:O95657|uniprotkb:B5BUK4|uniprotkb:B5BU74|ensembl:ENSP00000452746 intact:EBI-1211241|uniprotkb:A0N0K6|intact:EBI-28975949|uniprotkb:O95063|uniprotkb:O95064|uniprotkb:D4NZ71|uniprotkb:Q6IPX8|uniprotkb:Q8WVM1|uniprotkb:B1ALC8|uniprotkb:E9PLD8|uniprotkb:E9PPI1 psi-mi:ppip1_human(display_long)|uniprotkb:CD2-binding protein 1(gene name synonym)|uniprotkb:H-PIP(gene name synonym)|uniprotkb:PSTPIP1(gene name)|psi-mi:PSTPIP1(display_short)|uniprotkb:CD2BP1(gene name synonym) psi-mi:ptn22_human(display_long)|uniprotkb:PTPN22(gene name)|psi-mi:PTPN22(display_short)|uniprotkb:PTPN8(gene name synonym)|uniprotkb:Hematopoietic cell protein-tyrosine phosphatase 70Z-PEP(gene name synonym)|uniprotkb:Lymphoid phosphatase(gene name synonym)|uniprotkb:PEST-domain phosphatase(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Marcos et al. (2014) imex:IM-23065|pubmed:25040622 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-9635636|imex:IM-23065-3 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_003969.2|refseq:NP_001308064.1|refseq:NP_001308066.1|ensembl:ENSG00000140368(gene)|ensembl:ENST00000558012(transcript)|go:"GO:0001931"(uropod)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0006897"(endocytosis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007155"(cell adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0016020"(membrane)|go:"GO:0030027"(lamellipodium)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0032154"(cleavage furrow)|go:"GO:0042802"(identical protein binding)|go:"GO:0045087"(innate immune response)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051015"(actin filament binding)|interpro:IPR001060(Cdc15/Fes/CIP4)|interpro:IPR001452(Src homology-3)|interpro:IPR027267|interpro:IPR030777|interpro:IPR031160|interpro:IPR036028|mint:O43586|rcsb pdb:2DIL|reactome:R-HSA-844456|reactome:R-HSA-9660826 refseq:NP_001180360.1|refseq:NP_036543.4|refseq:NP_057051.3|ensembl:ENST00000460620|ensembl:ENSP00000433141|ensembl:ENSG00000134242|refseq:NP_001295226.1|mint:Q9Y2R2|dip:DIP-29953N|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0004726"(non-membrane spanning protein tyrosine phosphatase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0006914"(autophagy)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016791"(phosphatase activity)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019900"(kinase binding)|go:"GO:0030217"(T cell differentiation)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032481"(positive regulation of type I interferon production)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032717"(negative regulation of interleukin-8 production)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032817"(regulation of natural killer cell proliferation)|go:"GO:0034141"(positive regulation of toll-like receptor 3 signaling pathway)|go:"GO:0034145"(positive regulation of toll-like receptor 4 signaling pathway)|go:"GO:0034157"(positive regulation of toll-like receptor 7 signaling pathway)|go:"GO:0034165"(positive regulation of toll-like receptor 9 signaling pathway)|go:"GO:0035335"(peptidyl-tyrosine dephosphorylation)|go:"GO:0035644"(phosphoanandamide dephosphorylation)|go:"GO:0043508"(negative regulation of JUN kinase activity)|go:"GO:0045088"(regulation of innate immune response)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0050855"(regulation of B cell receptor signaling pathway)|go:"GO:0050860"(negative regulation of T cell receptor signaling pathway)|go:"GO:0050868"(negative regulation of T cell activation)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070433"(negative regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway)|go:"GO:0071225"(cellular response to muramyl dipeptide)|go:"GO:0071663"(positive regulation of granzyme B production)|go:"GO:1901222"(regulation of NIK/NF-kappaB signaling)|go:"GO:1902523"(positive regulation of protein K63-linked ubiquitination)|go:"GO:1903753"(negative regulation of p38MAPK cascade)|go:"GO:2000566"(positive regulation of CD8-positive, alpha-beta T cell proliferation)|interpro:IPR000242(Protein-tyrosine phosphatase, receptor/non-receptor type)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR003595(Protein-tyrosine phosphatase, catalytic)|interpro:IPR016130(Protein-tyrosine phosphatase, active site)|interpro:IPR016276(Non-receptor tyrosine-protein phosphatase, 8/22)|interpro:IPR029021|rcsb pdb:2P6X|rcsb pdb:2QCJ|rcsb pdb:2QCT|rcsb pdb:3BRH|rcsb pdb:3H2X|rcsb pdb:3OLR|reactome:R-HSA-202430|rcsb pdb:3OMH|rcsb pdb:4J51|reactome:R-HSA-202427 - - - figure legend:f3d|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|dataset:IBD - Inflammatory bowel disease|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2014/06/30 2014/10/16 rogid:JWK4dCYdcVF6mKwe+hoOri1wwps9606 rogid:KyIn+zCiuuIacrwk5MUzPEUQqKQ9606 intact-crc:37959426D96EBC5B|rigid:o1RSJu71e+plLYsVan+ZH96Yf3A false mutation disrupting interaction:232-232|v5 tag:?-? myc tag:?-? - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q9Y2R2 uniprotkb:O43586 intact:EBI-1211241|uniprotkb:A0N0K6|intact:EBI-28975949|uniprotkb:O95063|uniprotkb:O95064|uniprotkb:D4NZ71|uniprotkb:Q6IPX8|uniprotkb:Q8WVM1|uniprotkb:B1ALC8|uniprotkb:E9PLD8|uniprotkb:E9PPI1 intact:EBI-1050964|uniprotkb:O43585|uniprotkb:O95657|uniprotkb:B5BUK4|uniprotkb:B5BU74|ensembl:ENSP00000452746 psi-mi:ptn22_human(display_long)|uniprotkb:PTPN22(gene name)|psi-mi:PTPN22(display_short)|uniprotkb:PTPN8(gene name synonym)|uniprotkb:Hematopoietic cell protein-tyrosine phosphatase 70Z-PEP(gene name synonym)|uniprotkb:Lymphoid phosphatase(gene name synonym)|uniprotkb:PEST-domain phosphatase(gene name synonym) psi-mi:ppip1_human(display_long)|uniprotkb:CD2-binding protein 1(gene name synonym)|uniprotkb:H-PIP(gene name synonym)|uniprotkb:PSTPIP1(gene name)|psi-mi:PSTPIP1(display_short)|uniprotkb:CD2BP1(gene name synonym) psi-mi:"MI:0096"(pull down) Marcos et al. (2014) imex:IM-23065|pubmed:25040622 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-9635700|imex:IM-23065-5 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001180360.1|refseq:NP_036543.4|refseq:NP_057051.3|ensembl:ENST00000460620|ensembl:ENSP00000433141|ensembl:ENSG00000134242|refseq:NP_001295226.1|mint:Q9Y2R2|dip:DIP-29953N|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0004726"(non-membrane spanning protein tyrosine phosphatase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0006914"(autophagy)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016791"(phosphatase activity)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019900"(kinase binding)|go:"GO:0030217"(T cell differentiation)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032481"(positive regulation of type I interferon production)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032717"(negative regulation of interleukin-8 production)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032817"(regulation of natural killer cell proliferation)|go:"GO:0034141"(positive regulation of toll-like receptor 3 signaling pathway)|go:"GO:0034145"(positive regulation of toll-like receptor 4 signaling pathway)|go:"GO:0034157"(positive regulation of toll-like receptor 7 signaling pathway)|go:"GO:0034165"(positive regulation of toll-like receptor 9 signaling pathway)|go:"GO:0035335"(peptidyl-tyrosine dephosphorylation)|go:"GO:0035644"(phosphoanandamide dephosphorylation)|go:"GO:0043508"(negative regulation of JUN kinase activity)|go:"GO:0045088"(regulation of innate immune response)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0050855"(regulation of B cell receptor signaling pathway)|go:"GO:0050860"(negative regulation of T cell receptor signaling pathway)|go:"GO:0050868"(negative regulation of T cell activation)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070433"(negative regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway)|go:"GO:0071225"(cellular response to muramyl dipeptide)|go:"GO:0071663"(positive regulation of granzyme B production)|go:"GO:1901222"(regulation of NIK/NF-kappaB signaling)|go:"GO:1902523"(positive regulation of protein K63-linked ubiquitination)|go:"GO:1903753"(negative regulation of p38MAPK cascade)|go:"GO:2000566"(positive regulation of CD8-positive, alpha-beta T cell proliferation)|interpro:IPR000242(Protein-tyrosine phosphatase, receptor/non-receptor type)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR003595(Protein-tyrosine phosphatase, catalytic)|interpro:IPR016130(Protein-tyrosine phosphatase, active site)|interpro:IPR016276(Non-receptor tyrosine-protein phosphatase, 8/22)|interpro:IPR029021|rcsb pdb:2P6X|rcsb pdb:2QCJ|rcsb pdb:2QCT|rcsb pdb:3BRH|rcsb pdb:3H2X|rcsb pdb:3OLR|reactome:R-HSA-202430|rcsb pdb:3OMH|rcsb pdb:4J51|reactome:R-HSA-202427 refseq:NP_003969.2|refseq:NP_001308064.1|refseq:NP_001308066.1|ensembl:ENSG00000140368(gene)|ensembl:ENST00000558012(transcript)|go:"GO:0001931"(uropod)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0006897"(endocytosis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007155"(cell adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0016020"(membrane)|go:"GO:0030027"(lamellipodium)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0032154"(cleavage furrow)|go:"GO:0042802"(identical protein binding)|go:"GO:0045087"(innate immune response)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051015"(actin filament binding)|interpro:IPR001060(Cdc15/Fes/CIP4)|interpro:IPR001452(Src homology-3)|interpro:IPR027267|interpro:IPR030777|interpro:IPR031160|interpro:IPR036028|mint:O43586|rcsb pdb:2DIL|reactome:R-HSA-844456|reactome:R-HSA-9660826 - - - figure legend:f3f|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|dataset:IBD - Inflammatory bowel disease|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2014/06/30 2014/10/16 rogid:KyIn+zCiuuIacrwk5MUzPEUQqKQ9606 rogid:JWK4dCYdcVF6mKwe+hoOri1wwps9606 intact-crc:A71C98D8B7CE4B7B|rigid:o1RSJu71e+plLYsVan+ZH96Yf3A false binding-associated region:796-804|glutathione s tranferase tag:?-? - - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0113"(western blot) uniprotkb:O43586 uniprotkb:Q9Y2R2 intact:EBI-1050964|uniprotkb:O43585|uniprotkb:O95657|uniprotkb:B5BUK4|uniprotkb:B5BU74|ensembl:ENSP00000452746 intact:EBI-1211241|uniprotkb:A0N0K6|intact:EBI-28975949|uniprotkb:O95063|uniprotkb:O95064|uniprotkb:D4NZ71|uniprotkb:Q6IPX8|uniprotkb:Q8WVM1|uniprotkb:B1ALC8|uniprotkb:E9PLD8|uniprotkb:E9PPI1 psi-mi:ppip1_human(display_long)|uniprotkb:CD2-binding protein 1(gene name synonym)|uniprotkb:H-PIP(gene name synonym)|uniprotkb:PSTPIP1(gene name)|psi-mi:PSTPIP1(display_short)|uniprotkb:CD2BP1(gene name synonym) psi-mi:ptn22_human(display_long)|uniprotkb:PTPN22(gene name)|psi-mi:PTPN22(display_short)|uniprotkb:PTPN8(gene name synonym)|uniprotkb:Hematopoietic cell protein-tyrosine phosphatase 70Z-PEP(gene name synonym)|uniprotkb:Lymphoid phosphatase(gene name synonym)|uniprotkb:PEST-domain phosphatase(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Marcos et al. (2014) imex:IM-23065|pubmed:25040622 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-9635728|imex:IM-23065-6 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_003969.2|refseq:NP_001308064.1|refseq:NP_001308066.1|ensembl:ENSG00000140368(gene)|ensembl:ENST00000558012(transcript)|go:"GO:0001931"(uropod)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0006897"(endocytosis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007155"(cell adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0016020"(membrane)|go:"GO:0030027"(lamellipodium)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0032154"(cleavage furrow)|go:"GO:0042802"(identical protein binding)|go:"GO:0045087"(innate immune response)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051015"(actin filament binding)|interpro:IPR001060(Cdc15/Fes/CIP4)|interpro:IPR001452(Src homology-3)|interpro:IPR027267|interpro:IPR030777|interpro:IPR031160|interpro:IPR036028|mint:O43586|rcsb pdb:2DIL|reactome:R-HSA-844456|reactome:R-HSA-9660826 refseq:NP_001180360.1|refseq:NP_036543.4|refseq:NP_057051.3|ensembl:ENST00000460620|ensembl:ENSP00000433141|ensembl:ENSG00000134242|refseq:NP_001295226.1|mint:Q9Y2R2|dip:DIP-29953N|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0004726"(non-membrane spanning protein tyrosine phosphatase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0006914"(autophagy)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016791"(phosphatase activity)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019900"(kinase binding)|go:"GO:0030217"(T cell differentiation)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032481"(positive regulation of type I interferon production)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032717"(negative regulation of interleukin-8 production)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032817"(regulation of natural killer cell proliferation)|go:"GO:0034141"(positive regulation of toll-like receptor 3 signaling pathway)|go:"GO:0034145"(positive regulation of toll-like receptor 4 signaling pathway)|go:"GO:0034157"(positive regulation of toll-like receptor 7 signaling pathway)|go:"GO:0034165"(positive regulation of toll-like receptor 9 signaling pathway)|go:"GO:0035335"(peptidyl-tyrosine dephosphorylation)|go:"GO:0035644"(phosphoanandamide dephosphorylation)|go:"GO:0043508"(negative regulation of JUN kinase activity)|go:"GO:0045088"(regulation of innate immune response)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0050855"(regulation of B cell receptor signaling pathway)|go:"GO:0050860"(negative regulation of T cell receptor signaling pathway)|go:"GO:0050868"(negative regulation of T cell activation)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070433"(negative regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway)|go:"GO:0071225"(cellular response to muramyl dipeptide)|go:"GO:0071663"(positive regulation of granzyme B production)|go:"GO:1901222"(regulation of NIK/NF-kappaB signaling)|go:"GO:1902523"(positive regulation of protein K63-linked ubiquitination)|go:"GO:1903753"(negative regulation of p38MAPK cascade)|go:"GO:2000566"(positive regulation of CD8-positive, alpha-beta T cell proliferation)|interpro:IPR000242(Protein-tyrosine phosphatase, receptor/non-receptor type)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR003595(Protein-tyrosine phosphatase, catalytic)|interpro:IPR016130(Protein-tyrosine phosphatase, active site)|interpro:IPR016276(Non-receptor tyrosine-protein phosphatase, 8/22)|interpro:IPR029021|rcsb pdb:2P6X|rcsb pdb:2QCJ|rcsb pdb:2QCT|rcsb pdb:3BRH|rcsb pdb:3H2X|rcsb pdb:3OLR|reactome:R-HSA-202430|rcsb pdb:3OMH|rcsb pdb:4J51|reactome:R-HSA-202427 - - - figure legend:f5b|dataset:Rare diseases - Interactions investigated in the context of Rare genetic disease|dataset:IBD - Inflammatory bowel disease|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-jurkat)|taxid:9606(Homo sapiens) - 2014/06/30 2014/10/16 rogid:JWK4dCYdcVF6mKwe+hoOri1wwps9606 rogid:KyIn+zCiuuIacrwk5MUzPEUQqKQ9606 intact-crc:EC63DFB7FBE26F33|rigid:o1RSJu71e+plLYsVan+ZH96Yf3A false v5 tag:?-?|mutation disrupting interaction:250-250 myc tag:?-? - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot)