#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q99497	uniprotkb:P46940	intact:EBI-1164361|uniprotkb:O14805|uniprotkb:Q6DR95|uniprotkb:Q7LFU2|uniprotkb:B2R4Z1|ensembl:ENSP00000340278|ensembl:ENSP00000366708|ensembl:ENSP00000366711|ensembl:ENSP00000418770|ensembl:ENSP00000465404	intact:EBI-297509|ensembl:ENSP00000268182|uniprotkb:A7MBM3	psi-mi:park7_human(display_long)|uniprotkb:PARK7(gene name)|psi-mi:PARK7(display_short)|uniprotkb:Oncogene DJ1(gene name synonym)|uniprotkb:Parkinsonism-associated deglycase(gene name synonym)|uniprotkb:Maillard deglycase(gene name synonym)|uniprotkb:Protein DJ-1(gene name synonym)|uniprotkb:Protein/nucleic acid deglycase DJ-1(gene name synonym)	psi-mi:iqga1_human(display_long)|uniprotkb:IQGAP1(gene name)|psi-mi:IQGAP1(display_short)|uniprotkb:KIAA0051(gene name synonym)|uniprotkb:p195(gene name synonym)	psi-mi:"MI:0676"(tandem affinity purification)	Ma et al. (2014)	imex:IM-23015|pubmed:24947010	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9685618|imex:IM-23015-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001116849.1|refseq:NP_009193.2|refseq:XP_005263481.1|go:"GO:0046295"(glycolate biosynthetic process)|go:"GO:0046826"(negative regulation of protein export from nucleus)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050681"(androgen receptor binding)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050787"(detoxification of mercury ion)|go:"GO:0050821"(protein stabilization)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051444"(negative regulation of ubiquitin-protein transferase activity)|go:"GO:0051583"(dopamine uptake involved in synaptic transmission)|go:"GO:0051881"(regulation of mitochondrial membrane potential)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051899"(membrane depolarization)|go:"GO:0051920"(peroxiredoxin activity)|go:"GO:0060081"(membrane hyperpolarization)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0060765"(regulation of androgen receptor signaling pathway)|go:"GO:0061727"(methylglyoxal catabolic process to lactate)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070994"(detection of oxidative stress)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098793"(presynapse)|go:"GO:0106044"(guanine deglycation)|go:"GO:0106045"(guanine deglycation, methylglyoxal removal)|go:"GO:0106046"(guanine deglycation, glyoxal removal)|go:"GO:0110095"(cellular detoxification of aldehyde)|go:"GO:0140041"(cellular detoxification of methylglyoxal)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1901671"(positive regulation of superoxide dismutase activity)|go:"GO:1901984"(negative regulation of protein acetylation)|go:"GO:1902177"(positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1902236"(negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1902903"(regulation of supramolecular fiber organization)|go:"GO:1902958"(positive regulation of mitochondrial electron transport, NADH to ubiquinone)|go:"GO:1903073"(negative regulation of death-inducing signaling complex assembly)|go:"GO:1903094"(negative regulation of protein K48-linked deubiquitination)|go:"GO:1903122"(negative regulation of TRAIL-activated apoptotic signaling pathway)|go:"GO:1903135"(cupric ion binding)|go:"GO:1903136"(cuprous ion binding)|go:"GO:1903168"(positive regulation of pyrroline-5-carboxylate reductase activity)|go:"GO:1903178"(positive regulation of tyrosine 3-monooxygenase activity)|go:"GO:1903181"(positive regulation of dopamine biosynthetic process)|go:"GO:1903189"(glyoxal metabolic process)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:1903200"(positive regulation of L-dopa decarboxylase activity)|go:"GO:1903202"(negative regulation of oxidative stress-induced cell death)|go:"GO:1903206"(negative regulation of hydrogen peroxide-induced cell death)|go:"GO:1903208"(negative regulation of hydrogen peroxide-induced neuron death)|go:"GO:1903377"(negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway)|go:"GO:1903384"(negative regulation of hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway)|go:"GO:1903427"(negative regulation of reactive oxygen species biosynthetic process)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1903599"(positive regulation of autophagy of mitochondrion)|go:"GO:1905259"(negative regulation of nitrosative stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1990381"(ubiquitin-specific protease binding)|go:"GO:1990422"("glyoxalase (glycolic acid-forming) activity")|go:"GO:2000157"(negative regulation of ubiquitin-specific protease activity)|go:"GO:2000277"(positive regulation of oxidative phosphorylation uncoupler activity)|go:"GO:2000679"(positive regulation of transcription regulatory region DNA binding)|go:"GO:2000825"(positive regulation of androgen receptor activity)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|go:"GO:2001268"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|interpro:IPR002818(ThiJ/PfpI)|interpro:IPR006287(DJ-1)|interpro:IPR029062|go:"GO:1903197"(positive regulation of L-dopa biosynthetic process)|rcsb pdb:3B36|rcsb pdb:3B38|rcsb pdb:3B3A|rcsb pdb:3BWE|rcsb pdb:3CY6|rcsb pdb:3CYF|rcsb pdb:3CZ9|rcsb pdb:3CZA|rcsb pdb:3EZG|mint:Q99497|rcsb pdb:1J42|rcsb pdb:1P5F|rcsb pdb:3F71|rcsb pdb:1PDV|rcsb pdb:1PDW|rcsb pdb:1PE0|rcsb pdb:1Q2U|rcsb pdb:3SF8|rcsb pdb:1SOA|rcsb pdb:1UCF|rcsb pdb:2OR3|rcsb pdb:2R1T|rcsb pdb:2R1U|rcsb pdb:2R1V|rcsb pdb:4BTE|rcsb pdb:2RK3|rcsb pdb:2RK4|rcsb pdb:2RK6|ensembl:ENSG00000116288(gene)|ensembl:ENST00000338639(transcript)|ensembl:ENST00000377488(transcript)|ensembl:ENST00000377491(transcript)|ensembl:ENST00000493678(transcript)|ensembl:ENST00000493373(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0002866"(positive regulation of acute inflammatory response to antigenic stimulus)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003729"(mRNA binding)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005507"(copper ion binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0006281"(DNA repair)|rcsb pdb:4MTC|rcsb pdb:4N0M|rcsb pdb:4N12|rcsb pdb:4OGF|rcsb pdb:4OQ4|rcsb pdb:4P2G|rcsb pdb:4P34|rcsb pdb:4P35|rcsb pdb:4P36|rcsb pdb:4RKW|rcsb pdb:4RKY|rcsb pdb:4S0Z|rcsb pdb:4ZGG|rcsb pdb:5IP5|rcsb pdb:5SY6|rcsb pdb:5SY9|rcsb pdb:5SYA|rcsb pdb:6AF5|rcsb pdb:6AF7|rcsb pdb:6AF9|rcsb pdb:6AFA|rcsb pdb:6AFB|rcsb pdb:6AFC|rcsb pdb:6AFD|rcsb pdb:6AFE|rcsb pdb:6AFF|rcsb pdb:6AFG|rcsb pdb:6AFH|rcsb pdb:6AFI|rcsb pdb:6AFJ|rcsb pdb:6AFL|rcsb pdb:6E5Z|rcsb pdb:6M8Z|rcsb pdb:7C62|reactome:R-HSA-3899300|reactome:R-HSA-9613829|reactome:R-HSA-9615710|reactome:R-HSA-9646399|rcsb pdb:4MNT|go:"GO:0006517"(protein deglycosylation)|go:"GO:0006914"(autophagy)|go:"GO:0006954"(inflammatory response)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007338"(single fertilization)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008233"(peptidase activity)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0009438"(methylglyoxal metabolic process)|go:"GO:0010273"(detoxification of copper ion)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016532"(superoxide dismutase copper chaperone activity)|go:"GO:0016570"(histone modification)|go:"GO:0016605"(PML body)|go:"GO:0016684"(oxidoreductase activity, acting on peroxide as acceptor)|go:"GO:0019249"(lactate biosynthetic process)|go:"GO:0019826"(oxygen sensor activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0019900"(kinase binding)|go:"GO:0019955"(cytokine binding)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0030424"(axon)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0032435"(negative regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0033182"(regulation of histone ubiquitination)|go:"GO:0033234"(negative regulation of protein sumoylation)|go:"GO:0033864"("positive regulation of NAD(P)H oxidase activity")|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0035065"(regulation of histone acetylation)|go:"GO:0036470"(tyrosine 3-monooxygenase activator activity)|go:"GO:0036471"(cellular response to glyoxal)|go:"GO:0036478"(L-dopa decarboxylase activator activity)|go:"GO:0036524"(protein deglycase activity)|go:"GO:0036526"(peptidyl-cysteine deglycation)|go:"GO:0036527"(peptidyl-arginine deglycation)|go:"GO:0036528"(peptidyl-lysine deglycation)|go:"GO:0036529"(protein deglycation, glyoxal removal)|go:"GO:0036530"(protein deglycation, methylglyoxal removal)|go:"GO:0036531"(glutathione deglycation)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042743"(hydrogen peroxide metabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043523"(regulation of neuron apoptotic process)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0044297"(cell body)|go:"GO:0030073"(insulin secretion)|go:"GO:0044388"(small protein activating enzyme binding)|go:"GO:0044390"(ubiquitin-like protein conjugating enzyme binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045296"(cadherin binding)|go:"GO:0045340"(mercury ion binding)|dip:DIP-35515N	ensembl:ENSG00000140575(gene)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005547"(phosphatidylinositol-3,4,5-trisphosphate binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|ensembl:ENST00000268182(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0005925"(focal adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0005078"(MAP-kinase scaffold activity)|go:"GO:0005095"(GTPase inhibitor activity)|go:"GO:0007346"(regulation of mitotic cell cycle)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0016477"(cell migration)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0030496"(midbody)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0036057"(slit diaphragm)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0043005"(neuron projection)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0044548"(S100 protein binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045296"(cadherin binding)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0051015"(actin filament binding)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0072015"(glomerular visceral epithelial cell development)|go:"GO:1900006"(positive regulation of dendrite development)|go:"GO:1900086"(positive regulation of peptidyl-tyrosine autophosphorylation)|go:"GO:1903829"(positive regulation of protein localization)|go:"GO:1904754"(positive regulation of vascular associated smooth muscle cell migration)|go:"GO:1990138"(neuron projection extension)|go:"GO:1990776"(response to angiotensin)|interpro:IPR000048(IQ calmodulin-binding region)|go:"GO:0030667"(secretory granule membrane)|interpro:IPR000593(RasGAP protein, C-terminal)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR001936(Ras GTPase-activating protein)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR023152|interpro:IPR027417|interpro:IPR036872|mint:P46940|rcsb pdb:1X0H|rcsb pdb:2RR8|rcsb pdb:3FAY|rcsb pdb:3I6X|rcsb pdb:5L0O|reactome:R-HSA-373753|reactome:R-HSA-381676|reactome:R-HSA-5626467|reactome:R-HSA-5674135|reactome:R-HSA-6798695|reactome:R-HSA-6802946|reactome:R-HSA-6802948|reactome:R-HSA-6802952|reactome:R-HSA-6802955|reactome:R-HSA-8980692|reactome:R-HSA-9013106|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013406|reactome:R-HSA-9013420|reactome:R-HSA-9013424|reactome:R-HSA-9649948|reactome:R-HSA-9656223|refseq:NP_003861.1|dip:DIP-32597N	-	-	-	figure legend:1A|dataset:Parkinsons - Interactions investigated in the context of Parkinsons disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells)	-	2014/07/02	2014/10/16	rogid:i5ah4UPCf+4cD51ClZNggMFJMDo9606	rogid:nXO2Z6Qn8EQGfziT8dnWz1pbK/w9606	intact-crc:538BEE0C7482D8DC|rigid:oLRdzp8P3Udz6ir3xXQ2MkIEyd8	false	flag tag:?-?|ha tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q99497	uniprotkb:P00441	intact:EBI-1164361|uniprotkb:O14805|uniprotkb:Q6DR95|uniprotkb:Q7LFU2|uniprotkb:B2R4Z1|ensembl:ENSP00000340278|ensembl:ENSP00000366708|ensembl:ENSP00000366711|ensembl:ENSP00000418770|ensembl:ENSP00000465404	intact:EBI-990792|uniprotkb:A6NHJ0|uniprotkb:Q16669|uniprotkb:Q16711|uniprotkb:Q16838|uniprotkb:Q16839|uniprotkb:Q16840|uniprotkb:Q6NR85|ensembl:ENSP00000270142|uniprotkb:D3DSE4	psi-mi:park7_human(display_long)|uniprotkb:PARK7(gene name)|psi-mi:PARK7(display_short)|uniprotkb:Oncogene DJ1(gene name synonym)|uniprotkb:Parkinsonism-associated deglycase(gene name synonym)|uniprotkb:Maillard deglycase(gene name synonym)|uniprotkb:Protein DJ-1(gene name synonym)|uniprotkb:Protein/nucleic acid deglycase DJ-1(gene name synonym)	psi-mi:sodc_human(display_long)|uniprotkb:Superoxide dismutase 1(gene name synonym)|uniprotkb:SOD1(gene name)|psi-mi:SOD1(display_short)	psi-mi:"MI:0676"(tandem affinity purification)	Ma et al. (2014)	imex:IM-23015|pubmed:24947010	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9685618|imex:IM-23015-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001116849.1|refseq:NP_009193.2|refseq:XP_005263481.1|go:"GO:0046295"(glycolate biosynthetic process)|go:"GO:0046826"(negative regulation of protein export from nucleus)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050681"(androgen receptor binding)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050787"(detoxification of mercury ion)|go:"GO:0050821"(protein stabilization)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051444"(negative regulation of ubiquitin-protein transferase activity)|go:"GO:0051583"(dopamine uptake involved in synaptic transmission)|go:"GO:0051881"(regulation of mitochondrial membrane potential)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051899"(membrane depolarization)|go:"GO:0051920"(peroxiredoxin activity)|go:"GO:0060081"(membrane hyperpolarization)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0060765"(regulation of androgen receptor signaling pathway)|go:"GO:0061727"(methylglyoxal catabolic process to lactate)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070994"(detection of oxidative stress)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098793"(presynapse)|go:"GO:0106044"(guanine deglycation)|go:"GO:0106045"(guanine deglycation, methylglyoxal removal)|go:"GO:0106046"(guanine deglycation, glyoxal removal)|go:"GO:0110095"(cellular detoxification of aldehyde)|go:"GO:0140041"(cellular detoxification of methylglyoxal)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1901671"(positive regulation of superoxide dismutase activity)|go:"GO:1901984"(negative regulation of protein acetylation)|go:"GO:1902177"(positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1902236"(negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1902903"(regulation of supramolecular fiber organization)|go:"GO:1902958"(positive regulation of mitochondrial electron transport, NADH to ubiquinone)|go:"GO:1903073"(negative regulation of death-inducing signaling complex assembly)|go:"GO:1903094"(negative regulation of protein K48-linked deubiquitination)|go:"GO:1903122"(negative regulation of TRAIL-activated apoptotic signaling pathway)|go:"GO:1903135"(cupric ion binding)|go:"GO:1903136"(cuprous ion binding)|go:"GO:1903168"(positive regulation of pyrroline-5-carboxylate reductase activity)|go:"GO:1903178"(positive regulation of tyrosine 3-monooxygenase activity)|go:"GO:1903181"(positive regulation of dopamine biosynthetic process)|go:"GO:1903189"(glyoxal metabolic process)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:1903200"(positive regulation of L-dopa decarboxylase activity)|go:"GO:1903202"(negative regulation of oxidative stress-induced cell death)|go:"GO:1903206"(negative regulation of hydrogen peroxide-induced cell death)|go:"GO:1903208"(negative regulation of hydrogen peroxide-induced neuron death)|go:"GO:1903377"(negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway)|go:"GO:1903384"(negative regulation of hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway)|go:"GO:1903427"(negative regulation of reactive oxygen species biosynthetic process)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1903599"(positive regulation of autophagy of mitochondrion)|go:"GO:1905259"(negative regulation of nitrosative stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1990381"(ubiquitin-specific protease binding)|go:"GO:1990422"("glyoxalase (glycolic acid-forming) activity")|go:"GO:2000157"(negative regulation of ubiquitin-specific protease activity)|go:"GO:2000277"(positive regulation of oxidative phosphorylation uncoupler activity)|go:"GO:2000679"(positive regulation of transcription regulatory region DNA binding)|go:"GO:2000825"(positive regulation of androgen receptor activity)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|go:"GO:2001268"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|interpro:IPR002818(ThiJ/PfpI)|interpro:IPR006287(DJ-1)|interpro:IPR029062|go:"GO:1903197"(positive regulation of L-dopa biosynthetic process)|rcsb pdb:3B36|rcsb pdb:3B38|rcsb pdb:3B3A|rcsb pdb:3BWE|rcsb pdb:3CY6|rcsb pdb:3CYF|rcsb pdb:3CZ9|rcsb pdb:3CZA|rcsb pdb:3EZG|mint:Q99497|rcsb pdb:1J42|rcsb pdb:1P5F|rcsb pdb:3F71|rcsb pdb:1PDV|rcsb pdb:1PDW|rcsb pdb:1PE0|rcsb pdb:1Q2U|rcsb pdb:3SF8|rcsb pdb:1SOA|rcsb pdb:1UCF|rcsb pdb:2OR3|rcsb pdb:2R1T|rcsb pdb:2R1U|rcsb pdb:2R1V|rcsb pdb:4BTE|rcsb pdb:2RK3|rcsb pdb:2RK4|rcsb pdb:2RK6|ensembl:ENSG00000116288(gene)|ensembl:ENST00000338639(transcript)|ensembl:ENST00000377488(transcript)|ensembl:ENST00000377491(transcript)|ensembl:ENST00000493678(transcript)|ensembl:ENST00000493373(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0002866"(positive regulation of acute inflammatory response to antigenic stimulus)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003729"(mRNA binding)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005507"(copper ion binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0006281"(DNA repair)|rcsb pdb:4MTC|rcsb pdb:4N0M|rcsb pdb:4N12|rcsb pdb:4OGF|rcsb pdb:4OQ4|rcsb pdb:4P2G|rcsb pdb:4P34|rcsb pdb:4P35|rcsb pdb:4P36|rcsb pdb:4RKW|rcsb pdb:4RKY|rcsb pdb:4S0Z|rcsb pdb:4ZGG|rcsb pdb:5IP5|rcsb pdb:5SY6|rcsb pdb:5SY9|rcsb pdb:5SYA|rcsb pdb:6AF5|rcsb pdb:6AF7|rcsb pdb:6AF9|rcsb pdb:6AFA|rcsb pdb:6AFB|rcsb pdb:6AFC|rcsb pdb:6AFD|rcsb pdb:6AFE|rcsb pdb:6AFF|rcsb pdb:6AFG|rcsb pdb:6AFH|rcsb pdb:6AFI|rcsb pdb:6AFJ|rcsb pdb:6AFL|rcsb pdb:6E5Z|rcsb pdb:6M8Z|rcsb pdb:7C62|reactome:R-HSA-3899300|reactome:R-HSA-9613829|reactome:R-HSA-9615710|reactome:R-HSA-9646399|rcsb pdb:4MNT|go:"GO:0006517"(protein deglycosylation)|go:"GO:0006914"(autophagy)|go:"GO:0006954"(inflammatory response)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007338"(single fertilization)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008233"(peptidase activity)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0009438"(methylglyoxal metabolic process)|go:"GO:0010273"(detoxification of copper ion)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016532"(superoxide dismutase copper chaperone activity)|go:"GO:0016570"(histone modification)|go:"GO:0016605"(PML body)|go:"GO:0016684"(oxidoreductase activity, acting on peroxide as acceptor)|go:"GO:0019249"(lactate biosynthetic process)|go:"GO:0019826"(oxygen sensor activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0019900"(kinase binding)|go:"GO:0019955"(cytokine binding)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0030424"(axon)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0032435"(negative regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0033182"(regulation of histone ubiquitination)|go:"GO:0033234"(negative regulation of protein sumoylation)|go:"GO:0033864"("positive regulation of NAD(P)H oxidase activity")|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0035065"(regulation of histone acetylation)|go:"GO:0036470"(tyrosine 3-monooxygenase activator activity)|go:"GO:0036471"(cellular response to glyoxal)|go:"GO:0036478"(L-dopa decarboxylase activator activity)|go:"GO:0036524"(protein deglycase activity)|go:"GO:0036526"(peptidyl-cysteine deglycation)|go:"GO:0036527"(peptidyl-arginine deglycation)|go:"GO:0036528"(peptidyl-lysine deglycation)|go:"GO:0036529"(protein deglycation, glyoxal removal)|go:"GO:0036530"(protein deglycation, methylglyoxal removal)|go:"GO:0036531"(glutathione deglycation)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042743"(hydrogen peroxide metabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043523"(regulation of neuron apoptotic process)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0044297"(cell body)|go:"GO:0030073"(insulin secretion)|go:"GO:0044388"(small protein activating enzyme binding)|go:"GO:0044390"(ubiquitin-like protein conjugating enzyme binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045296"(cadherin binding)|go:"GO:0045340"(mercury ion binding)|dip:DIP-35515N	ensembl:ENSG00000142168(gene)|ensembl:ENST00000270142(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0000303"(response to superoxide)|go:"GO:0001541"(ovarian follicle development)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0001890"(placenta development)|go:"GO:0001895"(retina homeostasis)|go:"GO:0002262"(myeloid cell homeostasis)|go:"GO:0004784"(superoxide dismutase activity)|go:"GO:0005507"(copper ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005764"(lysosome)|go:"GO:0005777"(peroxisome)|go:"GO:0005829"(cytosol)|go:"GO:0006749"(glutathione metabolic process)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006879"(cellular iron ion homeostasis)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007566"(embryo implantation)|go:"GO:0007569"(cell aging)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008089"(anterograde axonal transport)|go:"GO:0008090"(retrograde axonal transport)|go:"GO:0001975"(response to amphetamine)|go:"GO:0008217"(regulation of blood pressure)|go:"GO:0032287"(peripheral nervous system myelin maintenance)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0032930"(positive regulation of superoxide anion generation)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033081"(regulation of T cell differentiation in thymus)|go:"GO:0034465"(response to carbon monoxide)|go:"GO:0035865"(cellular response to potassium ion)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0042493"|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042554"(superoxide anion generation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043085"(positive regulation of catalytic activity)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0045471"(response to ethanol)|go:"GO:0045541"(negative regulation of cholesterol biosynthetic process)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0046620"(regulation of organ growth)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009408"(response to heat)|go:"GO:0010033"(response to organic substance)|go:"GO:0019226"(transmission of nerve impulse)|go:"GO:0019430"(removal of superoxide radicals)|go:"GO:0030346"(protein phosphatase 2B binding)|go:"GO:0031045"(dense core granule)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031667"(response to nutrient levels)|interpro:IPR024134|interpro:IPR036423|mint:P00441|rcsb pdb:1AZV|rcsb pdb:1BA9|rcsb pdb:1DSW|rcsb pdb:1FUN|rcsb pdb:1HL4|rcsb pdb:1HL5|rcsb pdb:1KMG|rcsb pdb:1L3N|rcsb pdb:1MFM|rcsb pdb:1N18|rcsb pdb:1N19|interpro:IPR018152|rcsb pdb:1OEZ|rcsb pdb:1OZT|rcsb pdb:1OZU|rcsb pdb:1P1V|rcsb pdb:1PTZ|rcsb pdb:1PU0|rcsb pdb:1RK7|rcsb pdb:1SOS|rcsb pdb:1SPD|rcsb pdb:1UXL|rcsb pdb:1UXM|rcsb pdb:2AF2|rcsb pdb:2C9S|rcsb pdb:2C9U|rcsb pdb:2C9V|rcsb pdb:2GBT|rcsb pdb:2GBU|rcsb pdb:2GBV|rcsb pdb:2LU5|rcsb pdb:2MP3|rcsb pdb:2NAM|rcsb pdb:2NNX|rcsb pdb:2R27|rcsb pdb:2V0A|rcsb pdb:2VR6|rcsb pdb:2VR7|rcsb pdb:2VR8|rcsb pdb:2WKO|rcsb pdb:2WYT|rcsb pdb:2WYZ|rcsb pdb:2WZ0|rcsb pdb:2WZ5|rcsb pdb:2WZ6|rcsb pdb:2XJK|rcsb pdb:2XJL|rcsb pdb:2ZKW|rcsb pdb:2ZKX|rcsb pdb:2ZKY|rcsb pdb:3CQP|rcsb pdb:3CQQ|rcsb pdb:3ECU|rcsb pdb:3ECV|rcsb pdb:3ECW|rcsb pdb:3GQF|rcsb pdb:3GTV|rcsb pdb:3GZO|rcsb pdb:3GZP|rcsb pdb:3GZQ|rcsb pdb:3H2P|rcsb pdb:3H2Q|rcsb pdb:3HFF|rcsb pdb:3K91|rcsb pdb:3KH3|rcsb pdb:3KH4|rcsb pdb:3LTV|rcsb pdb:3QQD|rcsb pdb:3RE0|rcsb pdb:3T5W|rcsb pdb:4A7G|rcsb pdb:4A7Q|rcsb pdb:4A7S|rcsb pdb:4A7T|rcsb pdb:4A7U|rcsb pdb:4A7V|rcsb pdb:4B3E|rcsb pdb:4BCY|rcsb pdb:4BCZ|rcsb pdb:4BD4|rcsb pdb:4FF9|rcsb pdb:4MCM|rcsb pdb:4MCN|rcsb pdb:4NIN|rcsb pdb:4NIO|rcsb pdb:4NIP|rcsb pdb:4OH2|rcsb pdb:4SOD|rcsb pdb:4XCR|rcsb pdb:5DLI|rcsb pdb:5IIW|rcsb pdb:5J07|rcsb pdb:5J0C|rcsb pdb:5J0F|rcsb pdb:5J0G|rcsb pdb:5K02|rcsb pdb:5O3Y|rcsb pdb:5O40|rcsb pdb:5U9M|rcsb pdb:5WOR|rcsb pdb:5YTO|rcsb pdb:5YTU|rcsb pdb:5YUL|rcsb pdb:6A9O|rcsb pdb:6B79|rcsb pdb:6DTK|rcsb pdb:6FFK|rcsb pdb:6FLH|rcsb pdb:6FOI|rcsb pdb:6FOL|rcsb pdb:6FON|rcsb pdb:6FP6|rcsb pdb:6SPA|rcsb pdb:6SPH|rcsb pdb:6SPI|rcsb pdb:6SPJ|rcsb pdb:6SPK|rcsb pdb:6Z3V|rcsb pdb:6Z4G|rcsb pdb:6Z4H|rcsb pdb:6Z4I|rcsb pdb:6Z4J|rcsb pdb:6Z4K|rcsb pdb:6Z4L|rcsb pdb:6Z4M|rcsb pdb:6Z4O|reactome:R-HSA-114608|reactome:R-HSA-3299685|reactome:R-HSA-8950505|rcsb pdb:5WMJ|go:"GO:0046688"(response to copper ion)|go:"GO:0046716"(muscle cell cellular homeostasis)|go:"GO:0048538"(thymus development)|go:"GO:0048678"(response to axon injury)|go:"GO:0050665"(hydrogen peroxide biosynthetic process)|go:"GO:0046677"(response to antibiotic)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0051087"(chaperone binding)|go:"GO:0051881"(regulation of mitochondrial membrane potential)|go:"GO:0060047"(heart contraction)|go:"GO:0060052"(neurofilament cytoskeleton organization)|go:"GO:0060087"(relaxation of vascular associated smooth muscle)|go:"GO:0060088"(auditory receptor cell stereocilium organization)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0071318"(cellular response to ATP)|go:"GO:0072593"(reactive oxygen species metabolic process)|go:"GO:0097332"(response to antipsychotic drug)|go:"GO:1902177"(positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1904115"(axon cytoplasm)|interpro:IPR001424(Superoxide dismutase, copper/zinc binding)|refseq:NP_000445.1|dip:DIP-44941N	-	-	-	figure legend:1A|dataset:Parkinsons - Interactions investigated in the context of Parkinsons disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells)	-	2014/07/02	2014/10/16	rogid:i5ah4UPCf+4cD51ClZNggMFJMDo9606	rogid:W5O3CdnrxKm1kudXW04wxnCxTY09606	intact-crc:538BEE0C7482D8DC|rigid:oLRdzp8P3Udz6ir3xXQ2MkIEyd8	false	flag tag:?-?|ha tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q99497	uniprotkb:P26599	intact:EBI-1164361|uniprotkb:O14805|uniprotkb:Q6DR95|uniprotkb:Q7LFU2|uniprotkb:B2R4Z1|ensembl:ENSP00000340278|ensembl:ENSP00000366708|ensembl:ENSP00000366711|ensembl:ENSP00000418770|ensembl:ENSP00000465404	intact:EBI-350540|ensembl:ENSP00000014112|intact:EBI-744534|uniprotkb:Q9BUQ0	psi-mi:park7_human(display_long)|uniprotkb:PARK7(gene name)|psi-mi:PARK7(display_short)|uniprotkb:Oncogene DJ1(gene name synonym)|uniprotkb:Parkinsonism-associated deglycase(gene name synonym)|uniprotkb:Maillard deglycase(gene name synonym)|uniprotkb:Protein DJ-1(gene name synonym)|uniprotkb:Protein/nucleic acid deglycase DJ-1(gene name synonym)	psi-mi:ptbp1_human(display_long)|uniprotkb:PTBP1(gene name)|psi-mi:PTBP1(display_short)|uniprotkb:PTB(gene name synonym)|uniprotkb:Heterogeneous nuclear ribonucleoprotein I(gene name synonym)|uniprotkb:57 kDa RNA-binding protein PPTB-1(gene name synonym)	psi-mi:"MI:0676"(tandem affinity purification)	Ma et al. (2014)	imex:IM-23015|pubmed:24947010	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9685618|imex:IM-23015-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001116849.1|refseq:NP_009193.2|refseq:XP_005263481.1|go:"GO:0046295"(glycolate biosynthetic process)|go:"GO:0046826"(negative regulation of protein export from nucleus)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050681"(androgen receptor binding)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050787"(detoxification of mercury ion)|go:"GO:0050821"(protein stabilization)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051444"(negative regulation of ubiquitin-protein transferase activity)|go:"GO:0051583"(dopamine uptake involved in synaptic transmission)|go:"GO:0051881"(regulation of mitochondrial membrane potential)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051899"(membrane depolarization)|go:"GO:0051920"(peroxiredoxin activity)|go:"GO:0060081"(membrane hyperpolarization)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0060765"(regulation of androgen receptor signaling pathway)|go:"GO:0061727"(methylglyoxal catabolic process to lactate)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070994"(detection of oxidative stress)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098793"(presynapse)|go:"GO:0106044"(guanine deglycation)|go:"GO:0106045"(guanine deglycation, methylglyoxal removal)|go:"GO:0106046"(guanine deglycation, glyoxal removal)|go:"GO:0110095"(cellular detoxification of aldehyde)|go:"GO:0140041"(cellular detoxification of methylglyoxal)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1901671"(positive regulation of superoxide dismutase activity)|go:"GO:1901984"(negative regulation of protein acetylation)|go:"GO:1902177"(positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1902236"(negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1902903"(regulation of supramolecular fiber organization)|go:"GO:1902958"(positive regulation of mitochondrial electron transport, NADH to ubiquinone)|go:"GO:1903073"(negative regulation of death-inducing signaling complex assembly)|go:"GO:1903094"(negative regulation of protein K48-linked deubiquitination)|go:"GO:1903122"(negative regulation of TRAIL-activated apoptotic signaling pathway)|go:"GO:1903135"(cupric ion binding)|go:"GO:1903136"(cuprous ion binding)|go:"GO:1903168"(positive regulation of pyrroline-5-carboxylate reductase activity)|go:"GO:1903178"(positive regulation of tyrosine 3-monooxygenase activity)|go:"GO:1903181"(positive regulation of dopamine biosynthetic process)|go:"GO:1903189"(glyoxal metabolic process)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:1903200"(positive regulation of L-dopa decarboxylase activity)|go:"GO:1903202"(negative regulation of oxidative stress-induced cell death)|go:"GO:1903206"(negative regulation of hydrogen peroxide-induced cell death)|go:"GO:1903208"(negative regulation of hydrogen peroxide-induced neuron death)|go:"GO:1903377"(negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway)|go:"GO:1903384"(negative regulation of hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway)|go:"GO:1903427"(negative regulation of reactive oxygen species biosynthetic process)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1903599"(positive regulation of autophagy of mitochondrion)|go:"GO:1905259"(negative regulation of nitrosative stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1990381"(ubiquitin-specific protease binding)|go:"GO:1990422"("glyoxalase (glycolic acid-forming) activity")|go:"GO:2000157"(negative regulation of ubiquitin-specific protease activity)|go:"GO:2000277"(positive regulation of oxidative phosphorylation uncoupler activity)|go:"GO:2000679"(positive regulation of transcription regulatory region DNA binding)|go:"GO:2000825"(positive regulation of androgen receptor activity)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|go:"GO:2001268"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|interpro:IPR002818(ThiJ/PfpI)|interpro:IPR006287(DJ-1)|interpro:IPR029062|go:"GO:1903197"(positive regulation of L-dopa biosynthetic process)|rcsb pdb:3B36|rcsb pdb:3B38|rcsb pdb:3B3A|rcsb pdb:3BWE|rcsb pdb:3CY6|rcsb pdb:3CYF|rcsb pdb:3CZ9|rcsb pdb:3CZA|rcsb pdb:3EZG|mint:Q99497|rcsb pdb:1J42|rcsb pdb:1P5F|rcsb pdb:3F71|rcsb pdb:1PDV|rcsb pdb:1PDW|rcsb pdb:1PE0|rcsb pdb:1Q2U|rcsb pdb:3SF8|rcsb pdb:1SOA|rcsb pdb:1UCF|rcsb pdb:2OR3|rcsb pdb:2R1T|rcsb pdb:2R1U|rcsb pdb:2R1V|rcsb pdb:4BTE|rcsb pdb:2RK3|rcsb pdb:2RK4|rcsb pdb:2RK6|ensembl:ENSG00000116288(gene)|ensembl:ENST00000338639(transcript)|ensembl:ENST00000377488(transcript)|ensembl:ENST00000377491(transcript)|ensembl:ENST00000493678(transcript)|ensembl:ENST00000493373(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0002866"(positive regulation of acute inflammatory response to antigenic stimulus)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003729"(mRNA binding)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005507"(copper ion binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0006281"(DNA repair)|rcsb pdb:4MTC|rcsb pdb:4N0M|rcsb pdb:4N12|rcsb pdb:4OGF|rcsb pdb:4OQ4|rcsb pdb:4P2G|rcsb pdb:4P34|rcsb pdb:4P35|rcsb pdb:4P36|rcsb pdb:4RKW|rcsb pdb:4RKY|rcsb pdb:4S0Z|rcsb pdb:4ZGG|rcsb pdb:5IP5|rcsb pdb:5SY6|rcsb pdb:5SY9|rcsb pdb:5SYA|rcsb pdb:6AF5|rcsb pdb:6AF7|rcsb pdb:6AF9|rcsb pdb:6AFA|rcsb pdb:6AFB|rcsb pdb:6AFC|rcsb pdb:6AFD|rcsb pdb:6AFE|rcsb pdb:6AFF|rcsb pdb:6AFG|rcsb pdb:6AFH|rcsb pdb:6AFI|rcsb pdb:6AFJ|rcsb pdb:6AFL|rcsb pdb:6E5Z|rcsb pdb:6M8Z|rcsb pdb:7C62|reactome:R-HSA-3899300|reactome:R-HSA-9613829|reactome:R-HSA-9615710|reactome:R-HSA-9646399|rcsb pdb:4MNT|go:"GO:0006517"(protein deglycosylation)|go:"GO:0006914"(autophagy)|go:"GO:0006954"(inflammatory response)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007338"(single fertilization)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008233"(peptidase activity)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0009438"(methylglyoxal metabolic process)|go:"GO:0010273"(detoxification of copper ion)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016532"(superoxide dismutase copper chaperone activity)|go:"GO:0016570"(histone modification)|go:"GO:0016605"(PML body)|go:"GO:0016684"(oxidoreductase activity, acting on peroxide as acceptor)|go:"GO:0019249"(lactate biosynthetic process)|go:"GO:0019826"(oxygen sensor activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0019900"(kinase binding)|go:"GO:0019955"(cytokine binding)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0030424"(axon)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0032435"(negative regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0033182"(regulation of histone ubiquitination)|go:"GO:0033234"(negative regulation of protein sumoylation)|go:"GO:0033864"("positive regulation of NAD(P)H oxidase activity")|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0035065"(regulation of histone acetylation)|go:"GO:0036470"(tyrosine 3-monooxygenase activator activity)|go:"GO:0036471"(cellular response to glyoxal)|go:"GO:0036478"(L-dopa decarboxylase activator activity)|go:"GO:0036524"(protein deglycase activity)|go:"GO:0036526"(peptidyl-cysteine deglycation)|go:"GO:0036527"(peptidyl-arginine deglycation)|go:"GO:0036528"(peptidyl-lysine deglycation)|go:"GO:0036529"(protein deglycation, glyoxal removal)|go:"GO:0036530"(protein deglycation, methylglyoxal removal)|go:"GO:0036531"(glutathione deglycation)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042743"(hydrogen peroxide metabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043523"(regulation of neuron apoptotic process)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0044297"(cell body)|go:"GO:0030073"(insulin secretion)|go:"GO:0044388"(small protein activating enzyme binding)|go:"GO:0044390"(ubiquitin-like protein conjugating enzyme binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045296"(cadherin binding)|go:"GO:0045340"(mercury ion binding)|dip:DIP-35515N	refseq:NP_002810.1|refseq:NP_114367.1|refseq:NP_114368.1|go:"GO:0033119"(negative regulation of RNA splicing)|go:"GO:0035307"(positive regulation of protein dephosphorylation)|go:"GO:0036002"(pre-mRNA binding)|go:"GO:0043484"(regulation of RNA splicing)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0016020"(membrane)|go:"GO:0048025"(negative regulation of mRNA splicing, via spliceosome)|go:"GO:0051148"(negative regulation of muscle cell differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070886"(positive regulation of calcineurin-NFAT signaling cascade)|go:"GO:0075522"(IRES-dependent viral translational initiation)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR006536(HnRNP-L/PTB/hephaestus splicing factor)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR021790|interpro:IPR034798|interpro:IPR035000|interpro:IPR035001|interpro:IPR035979|mint:P26599|rcsb pdb:1QM9|rcsb pdb:1SJQ|ensembl:ENSG00000011304(gene)|ensembl:ENST00000349038(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006397"(mRNA processing)|go:"GO:0008187"(poly-pyrimidine tract binding)|go:"GO:0008380"(RNA splicing)|rcsb pdb:2AD9|rcsb pdb:2ADB|rcsb pdb:2ADC|rcsb pdb:2EVZ|rcsb pdb:2N3O|rcsb pdb:3ZZY|rcsb pdb:3ZZZ|reactome:R-HSA-6803529|reactome:R-HSA-72163|reactome:R-HSA-72203|rcsb pdb:1SJR	-	-	-	figure legend:1A|dataset:Parkinsons - Interactions investigated in the context of Parkinsons disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells)	-	2014/07/02	2014/10/16	rogid:i5ah4UPCf+4cD51ClZNggMFJMDo9606	rogid:fkSnYJELgHxDP0oAQEjBmSX0HIs9606	intact-crc:538BEE0C7482D8DC|rigid:oLRdzp8P3Udz6ir3xXQ2MkIEyd8	false	flag tag:?-?|ha tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q99497	uniprotkb:O14974	intact:EBI-1164361|uniprotkb:O14805|uniprotkb:Q6DR95|uniprotkb:Q7LFU2|uniprotkb:B2R4Z1|ensembl:ENSP00000340278|ensembl:ENSP00000366708|ensembl:ENSP00000366711|ensembl:ENSP00000418770|ensembl:ENSP00000465404	intact:EBI-351726|uniprotkb:Q2NKL4|uniprotkb:Q569H0|uniprotkb:Q86WU3|uniprotkb:Q8NFR6|uniprotkb:Q9BYH0|intact:EBI-28988491|uniprotkb:B4DZ09|uniprotkb:F8VWB4|ensembl:ENSP00000261207|ensembl:ENSP00000389168	psi-mi:park7_human(display_long)|uniprotkb:PARK7(gene name)|psi-mi:PARK7(display_short)|uniprotkb:Oncogene DJ1(gene name synonym)|uniprotkb:Parkinsonism-associated deglycase(gene name synonym)|uniprotkb:Maillard deglycase(gene name synonym)|uniprotkb:Protein DJ-1(gene name synonym)|uniprotkb:Protein/nucleic acid deglycase DJ-1(gene name synonym)	psi-mi:mypt1_human(display_long)|uniprotkb:PPP1R12A(gene name)|psi-mi:PPP1R12A(display_short)|uniprotkb:MBS(gene name synonym)|uniprotkb:MYPT1(gene name synonym)|uniprotkb:Myosin phosphatase-targeting subunit 1(gene name synonym)|uniprotkb:Protein phosphatase myosin-binding subunit(gene name synonym)	psi-mi:"MI:0676"(tandem affinity purification)	Ma et al. (2014)	imex:IM-23015|pubmed:24947010	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9685618|imex:IM-23015-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001116849.1|refseq:NP_009193.2|refseq:XP_005263481.1|go:"GO:0046295"(glycolate biosynthetic process)|go:"GO:0046826"(negative regulation of protein export from nucleus)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050681"(androgen receptor binding)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050787"(detoxification of mercury ion)|go:"GO:0050821"(protein stabilization)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051444"(negative regulation of ubiquitin-protein transferase activity)|go:"GO:0051583"(dopamine uptake involved in synaptic transmission)|go:"GO:0051881"(regulation of mitochondrial membrane potential)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051899"(membrane depolarization)|go:"GO:0051920"(peroxiredoxin activity)|go:"GO:0060081"(membrane hyperpolarization)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0060765"(regulation of androgen receptor signaling pathway)|go:"GO:0061727"(methylglyoxal catabolic process to lactate)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070994"(detection of oxidative stress)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098793"(presynapse)|go:"GO:0106044"(guanine deglycation)|go:"GO:0106045"(guanine deglycation, methylglyoxal removal)|go:"GO:0106046"(guanine deglycation, glyoxal removal)|go:"GO:0110095"(cellular detoxification of aldehyde)|go:"GO:0140041"(cellular detoxification of methylglyoxal)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1901671"(positive regulation of superoxide dismutase activity)|go:"GO:1901984"(negative regulation of protein acetylation)|go:"GO:1902177"(positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1902236"(negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1902903"(regulation of supramolecular fiber organization)|go:"GO:1902958"(positive regulation of mitochondrial electron transport, NADH to ubiquinone)|go:"GO:1903073"(negative regulation of death-inducing signaling complex assembly)|go:"GO:1903094"(negative regulation of protein K48-linked deubiquitination)|go:"GO:1903122"(negative regulation of TRAIL-activated apoptotic signaling pathway)|go:"GO:1903135"(cupric ion binding)|go:"GO:1903136"(cuprous ion binding)|go:"GO:1903168"(positive regulation of pyrroline-5-carboxylate reductase activity)|go:"GO:1903178"(positive regulation of tyrosine 3-monooxygenase activity)|go:"GO:1903181"(positive regulation of dopamine biosynthetic process)|go:"GO:1903189"(glyoxal metabolic process)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:1903200"(positive regulation of L-dopa decarboxylase activity)|go:"GO:1903202"(negative regulation of oxidative stress-induced cell death)|go:"GO:1903206"(negative regulation of hydrogen peroxide-induced cell death)|go:"GO:1903208"(negative regulation of hydrogen peroxide-induced neuron death)|go:"GO:1903377"(negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway)|go:"GO:1903384"(negative regulation of hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway)|go:"GO:1903427"(negative regulation of reactive oxygen species biosynthetic process)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1903599"(positive regulation of autophagy of mitochondrion)|go:"GO:1905259"(negative regulation of nitrosative stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1990381"(ubiquitin-specific protease binding)|go:"GO:1990422"("glyoxalase (glycolic acid-forming) activity")|go:"GO:2000157"(negative regulation of ubiquitin-specific protease activity)|go:"GO:2000277"(positive regulation of oxidative phosphorylation uncoupler activity)|go:"GO:2000679"(positive regulation of transcription regulatory region DNA binding)|go:"GO:2000825"(positive regulation of androgen receptor activity)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|go:"GO:2001268"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|interpro:IPR002818(ThiJ/PfpI)|interpro:IPR006287(DJ-1)|interpro:IPR029062|go:"GO:1903197"(positive regulation of L-dopa biosynthetic process)|rcsb pdb:3B36|rcsb pdb:3B38|rcsb pdb:3B3A|rcsb pdb:3BWE|rcsb pdb:3CY6|rcsb pdb:3CYF|rcsb pdb:3CZ9|rcsb pdb:3CZA|rcsb pdb:3EZG|mint:Q99497|rcsb pdb:1J42|rcsb pdb:1P5F|rcsb pdb:3F71|rcsb pdb:1PDV|rcsb pdb:1PDW|rcsb pdb:1PE0|rcsb pdb:1Q2U|rcsb pdb:3SF8|rcsb pdb:1SOA|rcsb pdb:1UCF|rcsb pdb:2OR3|rcsb pdb:2R1T|rcsb pdb:2R1U|rcsb pdb:2R1V|rcsb pdb:4BTE|rcsb pdb:2RK3|rcsb pdb:2RK4|rcsb pdb:2RK6|ensembl:ENSG00000116288(gene)|ensembl:ENST00000338639(transcript)|ensembl:ENST00000377488(transcript)|ensembl:ENST00000377491(transcript)|ensembl:ENST00000493678(transcript)|ensembl:ENST00000493373(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0002866"(positive regulation of acute inflammatory response to antigenic stimulus)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003729"(mRNA binding)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005507"(copper ion binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0006281"(DNA repair)|rcsb pdb:4MTC|rcsb pdb:4N0M|rcsb pdb:4N12|rcsb pdb:4OGF|rcsb pdb:4OQ4|rcsb pdb:4P2G|rcsb pdb:4P34|rcsb pdb:4P35|rcsb pdb:4P36|rcsb pdb:4RKW|rcsb pdb:4RKY|rcsb pdb:4S0Z|rcsb pdb:4ZGG|rcsb pdb:5IP5|rcsb pdb:5SY6|rcsb pdb:5SY9|rcsb pdb:5SYA|rcsb pdb:6AF5|rcsb pdb:6AF7|rcsb pdb:6AF9|rcsb pdb:6AFA|rcsb pdb:6AFB|rcsb pdb:6AFC|rcsb pdb:6AFD|rcsb pdb:6AFE|rcsb pdb:6AFF|rcsb pdb:6AFG|rcsb pdb:6AFH|rcsb pdb:6AFI|rcsb pdb:6AFJ|rcsb pdb:6AFL|rcsb pdb:6E5Z|rcsb pdb:6M8Z|rcsb pdb:7C62|reactome:R-HSA-3899300|reactome:R-HSA-9613829|reactome:R-HSA-9615710|reactome:R-HSA-9646399|rcsb pdb:4MNT|go:"GO:0006517"(protein deglycosylation)|go:"GO:0006914"(autophagy)|go:"GO:0006954"(inflammatory response)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007338"(single fertilization)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008233"(peptidase activity)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0009438"(methylglyoxal metabolic process)|go:"GO:0010273"(detoxification of copper ion)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016532"(superoxide dismutase copper chaperone activity)|go:"GO:0016570"(histone modification)|go:"GO:0016605"(PML body)|go:"GO:0016684"(oxidoreductase activity, acting on peroxide as acceptor)|go:"GO:0019249"(lactate biosynthetic process)|go:"GO:0019826"(oxygen sensor activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0019900"(kinase binding)|go:"GO:0019955"(cytokine binding)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0030424"(axon)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0032435"(negative regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0033182"(regulation of histone ubiquitination)|go:"GO:0033234"(negative regulation of protein sumoylation)|go:"GO:0033864"("positive regulation of NAD(P)H oxidase activity")|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0035065"(regulation of histone acetylation)|go:"GO:0036470"(tyrosine 3-monooxygenase activator activity)|go:"GO:0036471"(cellular response to glyoxal)|go:"GO:0036478"(L-dopa decarboxylase activator activity)|go:"GO:0036524"(protein deglycase activity)|go:"GO:0036526"(peptidyl-cysteine deglycation)|go:"GO:0036527"(peptidyl-arginine deglycation)|go:"GO:0036528"(peptidyl-lysine deglycation)|go:"GO:0036529"(protein deglycation, glyoxal removal)|go:"GO:0036530"(protein deglycation, methylglyoxal removal)|go:"GO:0036531"(glutathione deglycation)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042743"(hydrogen peroxide metabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043523"(regulation of neuron apoptotic process)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0044297"(cell body)|go:"GO:0030073"(insulin secretion)|go:"GO:0044388"(small protein activating enzyme binding)|go:"GO:0044390"(ubiquitin-like protein conjugating enzyme binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045296"(cadherin binding)|go:"GO:0045340"(mercury ion binding)|dip:DIP-35515N	refseq:NP_001137357.1|refseq:NP_001137358.1|refseq:NP_002471.1|refseq:NP_001231919.1|refseq:NP_001231921.1|refseq:XP_011536685.1|ensembl:ENSP00000261207|ensembl:ENST00000437004|ensembl:ENSP00000416769|ensembl:ENSP00000389168|ensembl:ENSP00000449514|ensembl:ENST00000550107|ensembl:ENSP00000446855|ensembl:ENST00000546369|dip:DIP-33186N|ensembl:ENSG00000058272(gene)|ensembl:ENST00000261207(transcript)|ensembl:ENST00000450142(transcript)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000776"(kinetochore)|go:"GO:0004857"(enzyme inhibitor activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0007098"(centrosome cycle)|go:"GO:0007165"(signal transduction)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0019208"(phosphatase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030018"(Z disc)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0031672"(A band)|go:"GO:0035507"(regulation of myosin-light-chain-phosphatase activity)|go:"GO:0035508"(positive regulation of myosin-light-chain-phosphatase activity)|go:"GO:0035690"|go:"GO:0043086"(negative regulation of catalytic activity)|go:"GO:0043292"(contractile fiber)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046822"(regulation of nucleocytoplasmic transport)|go:"GO:0071889"(14-3-3 protein binding)|go:"GO:0072357"(PTW/PP1 phosphatase complex)|interpro:IPR002110(Ankyrin)|interpro:IPR017401(Protein phosphatase 1, regulatory subunits 12A/B/C, eukaryote)|interpro:IPR020683|interpro:IPR031775|interpro:IPR036770|mint:O14974|rcsb pdb:2KJY|rcsb pdb:5HUZ|reactome:R-HSA-2565942|reactome:R-HSA-5625740|reactome:R-HSA-5625900|reactome:R-HSA-5627117|reactome:R-HSA-5627123	-	-	-	figure legend:1A|dataset:Parkinsons - Interactions investigated in the context of Parkinsons disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells)	-	2014/07/02	2014/10/16	rogid:i5ah4UPCf+4cD51ClZNggMFJMDo9606	rogid:Xi5lGskc0tWQCHtbYlgR45ERMSk9606	intact-crc:538BEE0C7482D8DC|rigid:oLRdzp8P3Udz6ir3xXQ2MkIEyd8	false	flag tag:?-?|ha tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q99497	uniprotkb:P63244	intact:EBI-1164361|uniprotkb:O14805|uniprotkb:Q6DR95|uniprotkb:Q7LFU2|uniprotkb:B2R4Z1|ensembl:ENSP00000340278|ensembl:ENSP00000366708|ensembl:ENSP00000366711|ensembl:ENSP00000418770|ensembl:ENSP00000465404	intact:EBI-296739|ensembl:ENSP00000426909|uniprotkb:P25388|uniprotkb:P99049|intact:EBI-923003|uniprotkb:B3KTJ0|uniprotkb:Q53HU2|uniprotkb:Q5J8M6|uniprotkb:Q5VLR4|uniprotkb:Q6FH47|intact:EBI-2559282|uniprotkb:D3DWS0	psi-mi:park7_human(display_long)|uniprotkb:PARK7(gene name)|psi-mi:PARK7(display_short)|uniprotkb:Oncogene DJ1(gene name synonym)|uniprotkb:Parkinsonism-associated deglycase(gene name synonym)|uniprotkb:Maillard deglycase(gene name synonym)|uniprotkb:Protein DJ-1(gene name synonym)|uniprotkb:Protein/nucleic acid deglycase DJ-1(gene name synonym)	psi-mi:rack1_human(display_long)|uniprotkb:Small ribosomal subunit protein RACK1(gene name synonym)|uniprotkb:HLC7(orf name)|uniprotkb:PIG21(orf name)|uniprotkb:RACK1(gene name)|psi-mi:RACK1(display_short)|uniprotkb:Cell proliferation-inducing gene 21 protein(gene name synonym)|uniprotkb:GNB2L1(gene name synonym)|uniprotkb:Guanine nucleotide-binding protein subunit beta-2-like 1(gene name synonym)|uniprotkb:Guanine nucleotide-binding protein subunit beta-like protein 12.3(gene name synonym)|uniprotkb:Human lung cancer oncogene 7 protein(gene name synonym)|uniprotkb:Receptor for activated C kinase(gene name synonym)	psi-mi:"MI:0676"(tandem affinity purification)	Ma et al. (2014)	imex:IM-23015|pubmed:24947010	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9685618|imex:IM-23015-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001116849.1|refseq:NP_009193.2|refseq:XP_005263481.1|go:"GO:0046295"(glycolate biosynthetic process)|go:"GO:0046826"(negative regulation of protein export from nucleus)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050681"(androgen receptor binding)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050787"(detoxification of mercury ion)|go:"GO:0050821"(protein stabilization)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051444"(negative regulation of ubiquitin-protein transferase activity)|go:"GO:0051583"(dopamine uptake involved in synaptic transmission)|go:"GO:0051881"(regulation of mitochondrial membrane potential)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051899"(membrane depolarization)|go:"GO:0051920"(peroxiredoxin activity)|go:"GO:0060081"(membrane hyperpolarization)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0060765"(regulation of androgen receptor signaling pathway)|go:"GO:0061727"(methylglyoxal catabolic process to lactate)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070994"(detection of oxidative stress)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098793"(presynapse)|go:"GO:0106044"(guanine deglycation)|go:"GO:0106045"(guanine deglycation, methylglyoxal removal)|go:"GO:0106046"(guanine deglycation, glyoxal removal)|go:"GO:0110095"(cellular detoxification of aldehyde)|go:"GO:0140041"(cellular detoxification of methylglyoxal)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1901671"(positive regulation of superoxide dismutase activity)|go:"GO:1901984"(negative regulation of protein acetylation)|go:"GO:1902177"(positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1902236"(negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1902903"(regulation of supramolecular fiber organization)|go:"GO:1902958"(positive regulation of mitochondrial electron transport, NADH to ubiquinone)|go:"GO:1903073"(negative regulation of death-inducing signaling complex assembly)|go:"GO:1903094"(negative regulation of protein K48-linked deubiquitination)|go:"GO:1903122"(negative regulation of TRAIL-activated apoptotic signaling pathway)|go:"GO:1903135"(cupric ion binding)|go:"GO:1903136"(cuprous ion binding)|go:"GO:1903168"(positive regulation of pyrroline-5-carboxylate reductase activity)|go:"GO:1903178"(positive regulation of tyrosine 3-monooxygenase activity)|go:"GO:1903181"(positive regulation of dopamine biosynthetic process)|go:"GO:1903189"(glyoxal metabolic process)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:1903200"(positive regulation of L-dopa decarboxylase activity)|go:"GO:1903202"(negative regulation of oxidative stress-induced cell death)|go:"GO:1903206"(negative regulation of hydrogen peroxide-induced cell death)|go:"GO:1903208"(negative regulation of hydrogen peroxide-induced neuron death)|go:"GO:1903377"(negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway)|go:"GO:1903384"(negative regulation of hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway)|go:"GO:1903427"(negative regulation of reactive oxygen species biosynthetic process)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1903599"(positive regulation of autophagy of mitochondrion)|go:"GO:1905259"(negative regulation of nitrosative stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1990381"(ubiquitin-specific protease binding)|go:"GO:1990422"("glyoxalase (glycolic acid-forming) activity")|go:"GO:2000157"(negative regulation of ubiquitin-specific protease activity)|go:"GO:2000277"(positive regulation of oxidative phosphorylation uncoupler activity)|go:"GO:2000679"(positive regulation of transcription regulatory region DNA binding)|go:"GO:2000825"(positive regulation of androgen receptor activity)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|go:"GO:2001268"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|interpro:IPR002818(ThiJ/PfpI)|interpro:IPR006287(DJ-1)|interpro:IPR029062|go:"GO:1903197"(positive regulation of L-dopa biosynthetic process)|rcsb pdb:3B36|rcsb pdb:3B38|rcsb pdb:3B3A|rcsb pdb:3BWE|rcsb pdb:3CY6|rcsb pdb:3CYF|rcsb pdb:3CZ9|rcsb pdb:3CZA|rcsb pdb:3EZG|mint:Q99497|rcsb pdb:1J42|rcsb pdb:1P5F|rcsb pdb:3F71|rcsb pdb:1PDV|rcsb pdb:1PDW|rcsb pdb:1PE0|rcsb pdb:1Q2U|rcsb pdb:3SF8|rcsb pdb:1SOA|rcsb pdb:1UCF|rcsb pdb:2OR3|rcsb pdb:2R1T|rcsb pdb:2R1U|rcsb pdb:2R1V|rcsb pdb:4BTE|rcsb pdb:2RK3|rcsb pdb:2RK4|rcsb pdb:2RK6|ensembl:ENSG00000116288(gene)|ensembl:ENST00000338639(transcript)|ensembl:ENST00000377488(transcript)|ensembl:ENST00000377491(transcript)|ensembl:ENST00000493678(transcript)|ensembl:ENST00000493373(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0002866"(positive regulation of acute inflammatory response to antigenic stimulus)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003729"(mRNA binding)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005507"(copper ion binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0006281"(DNA repair)|rcsb pdb:4MTC|rcsb pdb:4N0M|rcsb pdb:4N12|rcsb pdb:4OGF|rcsb pdb:4OQ4|rcsb pdb:4P2G|rcsb pdb:4P34|rcsb pdb:4P35|rcsb pdb:4P36|rcsb pdb:4RKW|rcsb pdb:4RKY|rcsb pdb:4S0Z|rcsb pdb:4ZGG|rcsb pdb:5IP5|rcsb pdb:5SY6|rcsb pdb:5SY9|rcsb pdb:5SYA|rcsb pdb:6AF5|rcsb pdb:6AF7|rcsb pdb:6AF9|rcsb pdb:6AFA|rcsb pdb:6AFB|rcsb pdb:6AFC|rcsb pdb:6AFD|rcsb pdb:6AFE|rcsb pdb:6AFF|rcsb pdb:6AFG|rcsb pdb:6AFH|rcsb pdb:6AFI|rcsb pdb:6AFJ|rcsb pdb:6AFL|rcsb pdb:6E5Z|rcsb pdb:6M8Z|rcsb pdb:7C62|reactome:R-HSA-3899300|reactome:R-HSA-9613829|reactome:R-HSA-9615710|reactome:R-HSA-9646399|rcsb pdb:4MNT|go:"GO:0006517"(protein deglycosylation)|go:"GO:0006914"(autophagy)|go:"GO:0006954"(inflammatory response)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007338"(single fertilization)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008233"(peptidase activity)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0009438"(methylglyoxal metabolic process)|go:"GO:0010273"(detoxification of copper ion)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016532"(superoxide dismutase copper chaperone activity)|go:"GO:0016570"(histone modification)|go:"GO:0016605"(PML body)|go:"GO:0016684"(oxidoreductase activity, acting on peroxide as acceptor)|go:"GO:0019249"(lactate biosynthetic process)|go:"GO:0019826"(oxygen sensor activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0019900"(kinase binding)|go:"GO:0019955"(cytokine binding)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0030424"(axon)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0032435"(negative regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0033182"(regulation of histone ubiquitination)|go:"GO:0033234"(negative regulation of protein sumoylation)|go:"GO:0033864"("positive regulation of NAD(P)H oxidase activity")|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0035065"(regulation of histone acetylation)|go:"GO:0036470"(tyrosine 3-monooxygenase activator activity)|go:"GO:0036471"(cellular response to glyoxal)|go:"GO:0036478"(L-dopa decarboxylase activator activity)|go:"GO:0036524"(protein deglycase activity)|go:"GO:0036526"(peptidyl-cysteine deglycation)|go:"GO:0036527"(peptidyl-arginine deglycation)|go:"GO:0036528"(peptidyl-lysine deglycation)|go:"GO:0036529"(protein deglycation, glyoxal removal)|go:"GO:0036530"(protein deglycation, methylglyoxal removal)|go:"GO:0036531"(glutathione deglycation)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042743"(hydrogen peroxide metabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043523"(regulation of neuron apoptotic process)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0044297"(cell body)|go:"GO:0030073"(insulin secretion)|go:"GO:0044388"(small protein activating enzyme binding)|go:"GO:0044390"(ubiquitin-like protein conjugating enzyme binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045296"(cadherin binding)|go:"GO:0045340"(mercury ion binding)|dip:DIP-35515N	rcsb pdb:4AOW|rcsb pdb:4UG0|rcsb pdb:4V6X|rcsb pdb:5A2Q|rcsb pdb:5AJ0|rcsb pdb:5FLX|rcsb pdb:5LKS|rcsb pdb:5OA3|rcsb pdb:5T2C|rcsb pdb:5VYC|rcsb pdb:6EK0|mint:P63244|rcsb pdb:6FEC|rcsb pdb:6G18|rcsb pdb:6G51|rcsb pdb:6G53|rcsb pdb:6G5H|rcsb pdb:6G5I|rcsb pdb:6IP5|rcsb pdb:6IP6|rcsb pdb:6IP8|rcsb pdb:6OLE|rcsb pdb:6OLF|rcsb pdb:6OLG|rcsb pdb:6OLI|rcsb pdb:6OLZ|rcsb pdb:6OM0|rcsb pdb:6OM7|rcsb pdb:6QZP|rcsb pdb:6XA1|rcsb pdb:6Y0G|rcsb pdb:6Y2L|rcsb pdb:6Y57|rcsb pdb:6YBS|rcsb pdb:6Z6L|rcsb pdb:6Z6M|rcsb pdb:6Z6N|rcsb pdb:6ZLW|rcsb pdb:6ZM7|rcsb pdb:6ZME|rcsb pdb:6ZMI|rcsb pdb:6ZMO|rcsb pdb:6ZMT|rcsb pdb:6ZMW|rcsb pdb:6ZN5|rcsb pdb:6ZOJ|rcsb pdb:6ZOL|rcsb pdb:6ZON|rcsb pdb:6ZP4|ensembl:ENSG00000204628(gene)|ensembl:ENST00000512805(transcript)|go:"GO:0001891"(phagocytic cup)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007049"(cell cycle)|go:"GO:0007369"(gastrulation)|go:"GO:0008200"(ion channel inhibitor activity)|go:"GO:0008656"(cysteine-type endopeptidase activator activity involved in apoptotic process)|rcsb pdb:6ZV6|rcsb pdb:6ZVH|rcsb pdb:6ZVJ|rcsb pdb:6ZXD|rcsb pdb:6ZXE|rcsb pdb:6ZXF|rcsb pdb:6ZXG|rcsb pdb:6ZXH|rcsb pdb:7A09|rcsb pdb:7K5I|reactome:R-HSA-5357905|reactome:R-HSA-5357956|reactome:R-HSA-5626978|rcsb pdb:6ZUO|go:"GO:0015935"(small ribosomal subunit)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019899"(enzyme binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0030292"(protein tyrosine kinase inhibitor activity)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030332"(cyclin binding)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030425"(dendrite)|go:"GO:0030496"(midbody)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0033137"(negative regulation of peptidyl-serine phosphorylation)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043022"(ribosome binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0042998"(positive regulation of Golgi to plasma membrane protein transport)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043204"(perikaryon)|go:"GO:0043473"(pigmentation)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045296"(cadherin binding)|go:"GO:0045879"(negative regulation of smoothened signaling pathway)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048511"(rhythmic process)|go:"GO:0050765"(negative regulation of phagocytosis)|go:"GO:0051302"(regulation of cell division)|go:"GO:0051343"(positive regulation of cyclic-nucleotide phosphodiesterase activity)|go:"GO:0051434"(BH3 domain binding)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:0051901"(positive regulation of mitochondrial depolarization)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0072344"(rescue of stalled ribosome)|go:"GO:1900102"(negative regulation of endoplasmic reticulum unfolded protein response)|go:"GO:1903208"(negative regulation of hydrogen peroxide-induced neuron death)|go:"GO:1990630"(IRE1-RACK1-PP2A complex)|go:"GO:2000114"(regulation of establishment of cell polarity)|go:"GO:2000543"(positive regulation of gastrulation)|go:"GO:2001244"(positive regulation of intrinsic apoptotic signaling pathway)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR036322|go:"GO:0060090"(molecular adaptor activity)|refseq:NP_006089.1|dip:DIP-46736N	-	-	-	figure legend:1A|dataset:Parkinsons - Interactions investigated in the context of Parkinsons disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells)	-	2014/07/02	2014/10/16	rogid:i5ah4UPCf+4cD51ClZNggMFJMDo9606	rogid:LXHlhPtxUzHJNncoPteGw2iXsFg9606	intact-crc:538BEE0C7482D8DC|rigid:oLRdzp8P3Udz6ir3xXQ2MkIEyd8	false	flag tag:?-?|ha tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:P63244	uniprotkb:Q99497	intact:EBI-296739|ensembl:ENSP00000426909|uniprotkb:P25388|uniprotkb:P99049|intact:EBI-923003|uniprotkb:B3KTJ0|uniprotkb:Q53HU2|uniprotkb:Q5J8M6|uniprotkb:Q5VLR4|uniprotkb:Q6FH47|intact:EBI-2559282|uniprotkb:D3DWS0	intact:EBI-1164361|uniprotkb:O14805|uniprotkb:Q6DR95|uniprotkb:Q7LFU2|uniprotkb:B2R4Z1|ensembl:ENSP00000340278|ensembl:ENSP00000366708|ensembl:ENSP00000366711|ensembl:ENSP00000418770|ensembl:ENSP00000465404	psi-mi:rack1_human(display_long)|uniprotkb:Small ribosomal subunit protein RACK1(gene name synonym)|uniprotkb:HLC7(orf name)|uniprotkb:PIG21(orf name)|uniprotkb:RACK1(gene name)|psi-mi:RACK1(display_short)|uniprotkb:Cell proliferation-inducing gene 21 protein(gene name synonym)|uniprotkb:GNB2L1(gene name synonym)|uniprotkb:Guanine nucleotide-binding protein subunit beta-2-like 1(gene name synonym)|uniprotkb:Guanine nucleotide-binding protein subunit beta-like protein 12.3(gene name synonym)|uniprotkb:Human lung cancer oncogene 7 protein(gene name synonym)|uniprotkb:Receptor for activated C kinase(gene name synonym)	psi-mi:park7_human(display_long)|uniprotkb:PARK7(gene name)|psi-mi:PARK7(display_short)|uniprotkb:Oncogene DJ1(gene name synonym)|uniprotkb:Parkinsonism-associated deglycase(gene name synonym)|uniprotkb:Maillard deglycase(gene name synonym)|uniprotkb:Protein DJ-1(gene name synonym)|uniprotkb:Protein/nucleic acid deglycase DJ-1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Ma et al. (2014)	imex:IM-23015|pubmed:24947010	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9685813|imex:IM-23015-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rcsb pdb:4AOW|rcsb pdb:4UG0|rcsb pdb:4V6X|rcsb pdb:5A2Q|rcsb pdb:5AJ0|rcsb pdb:5FLX|rcsb pdb:5LKS|rcsb pdb:5OA3|rcsb pdb:5T2C|rcsb pdb:5VYC|rcsb pdb:6EK0|mint:P63244|rcsb pdb:6FEC|rcsb pdb:6G18|rcsb pdb:6G51|rcsb pdb:6G53|rcsb pdb:6G5H|rcsb pdb:6G5I|rcsb pdb:6IP5|rcsb pdb:6IP6|rcsb pdb:6IP8|rcsb pdb:6OLE|rcsb pdb:6OLF|rcsb pdb:6OLG|rcsb pdb:6OLI|rcsb pdb:6OLZ|rcsb pdb:6OM0|rcsb pdb:6OM7|rcsb pdb:6QZP|rcsb pdb:6XA1|rcsb pdb:6Y0G|rcsb pdb:6Y2L|rcsb pdb:6Y57|rcsb pdb:6YBS|rcsb pdb:6Z6L|rcsb pdb:6Z6M|rcsb pdb:6Z6N|rcsb pdb:6ZLW|rcsb pdb:6ZM7|rcsb pdb:6ZME|rcsb pdb:6ZMI|rcsb pdb:6ZMO|rcsb pdb:6ZMT|rcsb pdb:6ZMW|rcsb pdb:6ZN5|rcsb pdb:6ZOJ|rcsb pdb:6ZOL|rcsb pdb:6ZON|rcsb pdb:6ZP4|ensembl:ENSG00000204628(gene)|ensembl:ENST00000512805(transcript)|go:"GO:0001891"(phagocytic cup)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007049"(cell cycle)|go:"GO:0007369"(gastrulation)|go:"GO:0008200"(ion channel inhibitor activity)|go:"GO:0008656"(cysteine-type endopeptidase activator activity involved in apoptotic process)|rcsb pdb:6ZV6|rcsb pdb:6ZVH|rcsb pdb:6ZVJ|rcsb pdb:6ZXD|rcsb pdb:6ZXE|rcsb pdb:6ZXF|rcsb pdb:6ZXG|rcsb pdb:6ZXH|rcsb pdb:7A09|rcsb pdb:7K5I|reactome:R-HSA-5357905|reactome:R-HSA-5357956|reactome:R-HSA-5626978|rcsb pdb:6ZUO|go:"GO:0015935"(small ribosomal subunit)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019899"(enzyme binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0030292"(protein tyrosine kinase inhibitor activity)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030332"(cyclin binding)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030425"(dendrite)|go:"GO:0030496"(midbody)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0033137"(negative regulation of peptidyl-serine phosphorylation)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043022"(ribosome binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0042998"(positive regulation of Golgi to plasma membrane protein transport)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043204"(perikaryon)|go:"GO:0043473"(pigmentation)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045296"(cadherin binding)|go:"GO:0045879"(negative regulation of smoothened signaling pathway)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048511"(rhythmic process)|go:"GO:0050765"(negative regulation of phagocytosis)|go:"GO:0051302"(regulation of cell division)|go:"GO:0051343"(positive regulation of cyclic-nucleotide phosphodiesterase activity)|go:"GO:0051434"(BH3 domain binding)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:0051901"(positive regulation of mitochondrial depolarization)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0072344"(rescue of stalled ribosome)|go:"GO:1900102"(negative regulation of endoplasmic reticulum unfolded protein response)|go:"GO:1903208"(negative regulation of hydrogen peroxide-induced neuron death)|go:"GO:1990630"(IRE1-RACK1-PP2A complex)|go:"GO:2000114"(regulation of establishment of cell polarity)|go:"GO:2000543"(positive regulation of gastrulation)|go:"GO:2001244"(positive regulation of intrinsic apoptotic signaling pathway)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR036322|go:"GO:0060090"(molecular adaptor activity)|refseq:NP_006089.1|dip:DIP-46736N	refseq:NP_001116849.1|refseq:NP_009193.2|refseq:XP_005263481.1|go:"GO:0046295"(glycolate biosynthetic process)|go:"GO:0046826"(negative regulation of protein export from nucleus)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050681"(androgen receptor binding)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050787"(detoxification of mercury ion)|go:"GO:0050821"(protein stabilization)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051444"(negative regulation of ubiquitin-protein transferase activity)|go:"GO:0051583"(dopamine uptake involved in synaptic transmission)|go:"GO:0051881"(regulation of mitochondrial membrane potential)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051899"(membrane depolarization)|go:"GO:0051920"(peroxiredoxin activity)|go:"GO:0060081"(membrane hyperpolarization)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0060765"(regulation of androgen receptor signaling pathway)|go:"GO:0061727"(methylglyoxal catabolic process to lactate)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070994"(detection of oxidative stress)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098793"(presynapse)|go:"GO:0106044"(guanine deglycation)|go:"GO:0106045"(guanine deglycation, methylglyoxal removal)|go:"GO:0106046"(guanine deglycation, glyoxal removal)|go:"GO:0110095"(cellular detoxification of aldehyde)|go:"GO:0140041"(cellular detoxification of methylglyoxal)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1901671"(positive regulation of superoxide dismutase activity)|go:"GO:1901984"(negative regulation of protein acetylation)|go:"GO:1902177"(positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1902236"(negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1902903"(regulation of supramolecular fiber organization)|go:"GO:1902958"(positive regulation of mitochondrial electron transport, NADH to ubiquinone)|go:"GO:1903073"(negative regulation of death-inducing signaling complex assembly)|go:"GO:1903094"(negative regulation of protein K48-linked deubiquitination)|go:"GO:1903122"(negative regulation of TRAIL-activated apoptotic signaling pathway)|go:"GO:1903135"(cupric ion binding)|go:"GO:1903136"(cuprous ion binding)|go:"GO:1903168"(positive regulation of pyrroline-5-carboxylate reductase activity)|go:"GO:1903178"(positive regulation of tyrosine 3-monooxygenase activity)|go:"GO:1903181"(positive regulation of dopamine biosynthetic process)|go:"GO:1903189"(glyoxal metabolic process)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:1903200"(positive regulation of L-dopa decarboxylase activity)|go:"GO:1903202"(negative regulation of oxidative stress-induced cell death)|go:"GO:1903206"(negative regulation of hydrogen peroxide-induced cell death)|go:"GO:1903208"(negative regulation of hydrogen peroxide-induced neuron death)|go:"GO:1903377"(negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway)|go:"GO:1903384"(negative regulation of hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway)|go:"GO:1903427"(negative regulation of reactive oxygen species biosynthetic process)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1903599"(positive regulation of autophagy of mitochondrion)|go:"GO:1905259"(negative regulation of nitrosative stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1990381"(ubiquitin-specific protease binding)|go:"GO:1990422"("glyoxalase (glycolic acid-forming) activity")|go:"GO:2000157"(negative regulation of ubiquitin-specific protease activity)|go:"GO:2000277"(positive regulation of oxidative phosphorylation uncoupler activity)|go:"GO:2000679"(positive regulation of transcription regulatory region DNA binding)|go:"GO:2000825"(positive regulation of androgen receptor activity)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|go:"GO:2001268"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|interpro:IPR002818(ThiJ/PfpI)|interpro:IPR006287(DJ-1)|interpro:IPR029062|go:"GO:1903197"(positive regulation of L-dopa biosynthetic process)|rcsb pdb:3B36|rcsb pdb:3B38|rcsb pdb:3B3A|rcsb pdb:3BWE|rcsb pdb:3CY6|rcsb pdb:3CYF|rcsb pdb:3CZ9|rcsb pdb:3CZA|rcsb pdb:3EZG|mint:Q99497|rcsb pdb:1J42|rcsb pdb:1P5F|rcsb pdb:3F71|rcsb pdb:1PDV|rcsb pdb:1PDW|rcsb pdb:1PE0|rcsb pdb:1Q2U|rcsb pdb:3SF8|rcsb pdb:1SOA|rcsb pdb:1UCF|rcsb pdb:2OR3|rcsb pdb:2R1T|rcsb pdb:2R1U|rcsb pdb:2R1V|rcsb pdb:4BTE|rcsb pdb:2RK3|rcsb pdb:2RK4|rcsb pdb:2RK6|ensembl:ENSG00000116288(gene)|ensembl:ENST00000338639(transcript)|ensembl:ENST00000377488(transcript)|ensembl:ENST00000377491(transcript)|ensembl:ENST00000493678(transcript)|ensembl:ENST00000493373(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0002866"(positive regulation of acute inflammatory response to antigenic stimulus)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003729"(mRNA binding)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005507"(copper ion binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0006281"(DNA repair)|rcsb pdb:4MTC|rcsb pdb:4N0M|rcsb pdb:4N12|rcsb pdb:4OGF|rcsb pdb:4OQ4|rcsb pdb:4P2G|rcsb pdb:4P34|rcsb pdb:4P35|rcsb pdb:4P36|rcsb pdb:4RKW|rcsb pdb:4RKY|rcsb pdb:4S0Z|rcsb pdb:4ZGG|rcsb pdb:5IP5|rcsb pdb:5SY6|rcsb pdb:5SY9|rcsb pdb:5SYA|rcsb pdb:6AF5|rcsb pdb:6AF7|rcsb pdb:6AF9|rcsb pdb:6AFA|rcsb pdb:6AFB|rcsb pdb:6AFC|rcsb pdb:6AFD|rcsb pdb:6AFE|rcsb pdb:6AFF|rcsb pdb:6AFG|rcsb pdb:6AFH|rcsb pdb:6AFI|rcsb pdb:6AFJ|rcsb pdb:6AFL|rcsb pdb:6E5Z|rcsb pdb:6M8Z|rcsb pdb:7C62|reactome:R-HSA-3899300|reactome:R-HSA-9613829|reactome:R-HSA-9615710|reactome:R-HSA-9646399|rcsb pdb:4MNT|go:"GO:0006517"(protein deglycosylation)|go:"GO:0006914"(autophagy)|go:"GO:0006954"(inflammatory response)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007338"(single fertilization)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008233"(peptidase activity)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0009438"(methylglyoxal metabolic process)|go:"GO:0010273"(detoxification of copper ion)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016532"(superoxide dismutase copper chaperone activity)|go:"GO:0016570"(histone modification)|go:"GO:0016605"(PML body)|go:"GO:0016684"(oxidoreductase activity, acting on peroxide as acceptor)|go:"GO:0019249"(lactate biosynthetic process)|go:"GO:0019826"(oxygen sensor activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0019900"(kinase binding)|go:"GO:0019955"(cytokine binding)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0030424"(axon)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0032435"(negative regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0033182"(regulation of histone ubiquitination)|go:"GO:0033234"(negative regulation of protein sumoylation)|go:"GO:0033864"("positive regulation of NAD(P)H oxidase activity")|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0035065"(regulation of histone acetylation)|go:"GO:0036470"(tyrosine 3-monooxygenase activator activity)|go:"GO:0036471"(cellular response to glyoxal)|go:"GO:0036478"(L-dopa decarboxylase activator activity)|go:"GO:0036524"(protein deglycase activity)|go:"GO:0036526"(peptidyl-cysteine deglycation)|go:"GO:0036527"(peptidyl-arginine deglycation)|go:"GO:0036528"(peptidyl-lysine deglycation)|go:"GO:0036529"(protein deglycation, glyoxal removal)|go:"GO:0036530"(protein deglycation, methylglyoxal removal)|go:"GO:0036531"(glutathione deglycation)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042743"(hydrogen peroxide metabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043523"(regulation of neuron apoptotic process)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0044297"(cell body)|go:"GO:0030073"(insulin secretion)|go:"GO:0044388"(small protein activating enzyme binding)|go:"GO:0044390"(ubiquitin-like protein conjugating enzyme binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045296"(cadherin binding)|go:"GO:0045340"(mercury ion binding)|dip:DIP-35515N	-	-	-	figure legend:1C|dataset:Parkinsons - Interactions investigated in the context of Parkinsons disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2014/07/02	2014/10/16	rogid:LXHlhPtxUzHJNncoPteGw2iXsFg9606	rogid:i5ah4UPCf+4cD51ClZNggMFJMDo9606	intact-crc:924B59DF1D7435A0|rigid:7hZDNZUn/lAKROROlxcT2+KAIF0	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P63244	uniprotkb:Q99497	intact:EBI-296739|ensembl:ENSP00000426909|uniprotkb:P25388|uniprotkb:P99049|intact:EBI-923003|uniprotkb:B3KTJ0|uniprotkb:Q53HU2|uniprotkb:Q5J8M6|uniprotkb:Q5VLR4|uniprotkb:Q6FH47|intact:EBI-2559282|uniprotkb:D3DWS0	intact:EBI-1164361|uniprotkb:O14805|uniprotkb:Q6DR95|uniprotkb:Q7LFU2|uniprotkb:B2R4Z1|ensembl:ENSP00000340278|ensembl:ENSP00000366708|ensembl:ENSP00000366711|ensembl:ENSP00000418770|ensembl:ENSP00000465404	psi-mi:rack1_human(display_long)|uniprotkb:Small ribosomal subunit protein RACK1(gene name synonym)|uniprotkb:HLC7(orf name)|uniprotkb:PIG21(orf name)|uniprotkb:RACK1(gene name)|psi-mi:RACK1(display_short)|uniprotkb:Cell proliferation-inducing gene 21 protein(gene name synonym)|uniprotkb:GNB2L1(gene name synonym)|uniprotkb:Guanine nucleotide-binding protein subunit beta-2-like 1(gene name synonym)|uniprotkb:Guanine nucleotide-binding protein subunit beta-like protein 12.3(gene name synonym)|uniprotkb:Human lung cancer oncogene 7 protein(gene name synonym)|uniprotkb:Receptor for activated C kinase(gene name synonym)	psi-mi:park7_human(display_long)|uniprotkb:PARK7(gene name)|psi-mi:PARK7(display_short)|uniprotkb:Oncogene DJ1(gene name synonym)|uniprotkb:Parkinsonism-associated deglycase(gene name synonym)|uniprotkb:Maillard deglycase(gene name synonym)|uniprotkb:Protein DJ-1(gene name synonym)|uniprotkb:Protein/nucleic acid deglycase DJ-1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Ma et al. (2014)	imex:IM-23015|pubmed:24947010	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9685850|imex:IM-23015-6	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rcsb pdb:4AOW|rcsb pdb:4UG0|rcsb pdb:4V6X|rcsb pdb:5A2Q|rcsb pdb:5AJ0|rcsb pdb:5FLX|rcsb pdb:5LKS|rcsb pdb:5OA3|rcsb pdb:5T2C|rcsb pdb:5VYC|rcsb pdb:6EK0|mint:P63244|rcsb pdb:6FEC|rcsb pdb:6G18|rcsb pdb:6G51|rcsb pdb:6G53|rcsb pdb:6G5H|rcsb pdb:6G5I|rcsb pdb:6IP5|rcsb pdb:6IP6|rcsb pdb:6IP8|rcsb pdb:6OLE|rcsb pdb:6OLF|rcsb pdb:6OLG|rcsb pdb:6OLI|rcsb pdb:6OLZ|rcsb pdb:6OM0|rcsb pdb:6OM7|rcsb pdb:6QZP|rcsb pdb:6XA1|rcsb pdb:6Y0G|rcsb pdb:6Y2L|rcsb pdb:6Y57|rcsb pdb:6YBS|rcsb pdb:6Z6L|rcsb pdb:6Z6M|rcsb pdb:6Z6N|rcsb pdb:6ZLW|rcsb pdb:6ZM7|rcsb pdb:6ZME|rcsb pdb:6ZMI|rcsb pdb:6ZMO|rcsb pdb:6ZMT|rcsb pdb:6ZMW|rcsb pdb:6ZN5|rcsb pdb:6ZOJ|rcsb pdb:6ZOL|rcsb pdb:6ZON|rcsb pdb:6ZP4|ensembl:ENSG00000204628(gene)|ensembl:ENST00000512805(transcript)|go:"GO:0001891"(phagocytic cup)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007049"(cell cycle)|go:"GO:0007369"(gastrulation)|go:"GO:0008200"(ion channel inhibitor activity)|go:"GO:0008656"(cysteine-type endopeptidase activator activity involved in apoptotic process)|rcsb pdb:6ZV6|rcsb pdb:6ZVH|rcsb pdb:6ZVJ|rcsb pdb:6ZXD|rcsb pdb:6ZXE|rcsb pdb:6ZXF|rcsb pdb:6ZXG|rcsb pdb:6ZXH|rcsb pdb:7A09|rcsb pdb:7K5I|reactome:R-HSA-5357905|reactome:R-HSA-5357956|reactome:R-HSA-5626978|rcsb pdb:6ZUO|go:"GO:0015935"(small ribosomal subunit)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019899"(enzyme binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0030292"(protein tyrosine kinase inhibitor activity)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030332"(cyclin binding)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030425"(dendrite)|go:"GO:0030496"(midbody)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0033137"(negative regulation of peptidyl-serine phosphorylation)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043022"(ribosome binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0042998"(positive regulation of Golgi to plasma membrane protein transport)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043204"(perikaryon)|go:"GO:0043473"(pigmentation)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045296"(cadherin binding)|go:"GO:0045879"(negative regulation of smoothened signaling pathway)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048511"(rhythmic process)|go:"GO:0050765"(negative regulation of phagocytosis)|go:"GO:0051302"(regulation of cell division)|go:"GO:0051343"(positive regulation of cyclic-nucleotide phosphodiesterase activity)|go:"GO:0051434"(BH3 domain binding)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:0051901"(positive regulation of mitochondrial depolarization)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0072344"(rescue of stalled ribosome)|go:"GO:1900102"(negative regulation of endoplasmic reticulum unfolded protein response)|go:"GO:1903208"(negative regulation of hydrogen peroxide-induced neuron death)|go:"GO:1990630"(IRE1-RACK1-PP2A complex)|go:"GO:2000114"(regulation of establishment of cell polarity)|go:"GO:2000543"(positive regulation of gastrulation)|go:"GO:2001244"(positive regulation of intrinsic apoptotic signaling pathway)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR036322|go:"GO:0060090"(molecular adaptor activity)|refseq:NP_006089.1|dip:DIP-46736N	refseq:NP_001116849.1|refseq:NP_009193.2|refseq:XP_005263481.1|go:"GO:0046295"(glycolate biosynthetic process)|go:"GO:0046826"(negative regulation of protein export from nucleus)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050681"(androgen receptor binding)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050787"(detoxification of mercury ion)|go:"GO:0050821"(protein stabilization)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051444"(negative regulation of ubiquitin-protein transferase activity)|go:"GO:0051583"(dopamine uptake involved in synaptic transmission)|go:"GO:0051881"(regulation of mitochondrial membrane potential)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051899"(membrane depolarization)|go:"GO:0051920"(peroxiredoxin activity)|go:"GO:0060081"(membrane hyperpolarization)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0060765"(regulation of androgen receptor signaling pathway)|go:"GO:0061727"(methylglyoxal catabolic process to lactate)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070994"(detection of oxidative stress)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098793"(presynapse)|go:"GO:0106044"(guanine deglycation)|go:"GO:0106045"(guanine deglycation, methylglyoxal removal)|go:"GO:0106046"(guanine deglycation, glyoxal removal)|go:"GO:0110095"(cellular detoxification of aldehyde)|go:"GO:0140041"(cellular detoxification of methylglyoxal)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1901671"(positive regulation of superoxide dismutase activity)|go:"GO:1901984"(negative regulation of protein acetylation)|go:"GO:1902177"(positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1902236"(negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1902903"(regulation of supramolecular fiber organization)|go:"GO:1902958"(positive regulation of mitochondrial electron transport, NADH to ubiquinone)|go:"GO:1903073"(negative regulation of death-inducing signaling complex assembly)|go:"GO:1903094"(negative regulation of protein K48-linked deubiquitination)|go:"GO:1903122"(negative regulation of TRAIL-activated apoptotic signaling pathway)|go:"GO:1903135"(cupric ion binding)|go:"GO:1903136"(cuprous ion binding)|go:"GO:1903168"(positive regulation of pyrroline-5-carboxylate reductase activity)|go:"GO:1903178"(positive regulation of tyrosine 3-monooxygenase activity)|go:"GO:1903181"(positive regulation of dopamine biosynthetic process)|go:"GO:1903189"(glyoxal metabolic process)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:1903200"(positive regulation of L-dopa decarboxylase activity)|go:"GO:1903202"(negative regulation of oxidative stress-induced cell death)|go:"GO:1903206"(negative regulation of hydrogen peroxide-induced cell death)|go:"GO:1903208"(negative regulation of hydrogen peroxide-induced neuron death)|go:"GO:1903377"(negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway)|go:"GO:1903384"(negative regulation of hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway)|go:"GO:1903427"(negative regulation of reactive oxygen species biosynthetic process)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1903599"(positive regulation of autophagy of mitochondrion)|go:"GO:1905259"(negative regulation of nitrosative stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1990381"(ubiquitin-specific protease binding)|go:"GO:1990422"("glyoxalase (glycolic acid-forming) activity")|go:"GO:2000157"(negative regulation of ubiquitin-specific protease activity)|go:"GO:2000277"(positive regulation of oxidative phosphorylation uncoupler activity)|go:"GO:2000679"(positive regulation of transcription regulatory region DNA binding)|go:"GO:2000825"(positive regulation of androgen receptor activity)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|go:"GO:2001268"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|interpro:IPR002818(ThiJ/PfpI)|interpro:IPR006287(DJ-1)|interpro:IPR029062|go:"GO:1903197"(positive regulation of L-dopa biosynthetic process)|rcsb pdb:3B36|rcsb pdb:3B38|rcsb pdb:3B3A|rcsb pdb:3BWE|rcsb pdb:3CY6|rcsb pdb:3CYF|rcsb pdb:3CZ9|rcsb pdb:3CZA|rcsb pdb:3EZG|mint:Q99497|rcsb pdb:1J42|rcsb pdb:1P5F|rcsb pdb:3F71|rcsb pdb:1PDV|rcsb pdb:1PDW|rcsb pdb:1PE0|rcsb pdb:1Q2U|rcsb pdb:3SF8|rcsb pdb:1SOA|rcsb pdb:1UCF|rcsb pdb:2OR3|rcsb pdb:2R1T|rcsb pdb:2R1U|rcsb pdb:2R1V|rcsb pdb:4BTE|rcsb pdb:2RK3|rcsb pdb:2RK4|rcsb pdb:2RK6|ensembl:ENSG00000116288(gene)|ensembl:ENST00000338639(transcript)|ensembl:ENST00000377488(transcript)|ensembl:ENST00000377491(transcript)|ensembl:ENST00000493678(transcript)|ensembl:ENST00000493373(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0002866"(positive regulation of acute inflammatory response to antigenic stimulus)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003729"(mRNA binding)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005507"(copper ion binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0006281"(DNA repair)|rcsb pdb:4MTC|rcsb pdb:4N0M|rcsb pdb:4N12|rcsb pdb:4OGF|rcsb pdb:4OQ4|rcsb pdb:4P2G|rcsb pdb:4P34|rcsb pdb:4P35|rcsb pdb:4P36|rcsb pdb:4RKW|rcsb pdb:4RKY|rcsb pdb:4S0Z|rcsb pdb:4ZGG|rcsb pdb:5IP5|rcsb pdb:5SY6|rcsb pdb:5SY9|rcsb pdb:5SYA|rcsb pdb:6AF5|rcsb pdb:6AF7|rcsb pdb:6AF9|rcsb pdb:6AFA|rcsb pdb:6AFB|rcsb pdb:6AFC|rcsb pdb:6AFD|rcsb pdb:6AFE|rcsb pdb:6AFF|rcsb pdb:6AFG|rcsb pdb:6AFH|rcsb pdb:6AFI|rcsb pdb:6AFJ|rcsb pdb:6AFL|rcsb pdb:6E5Z|rcsb pdb:6M8Z|rcsb pdb:7C62|reactome:R-HSA-3899300|reactome:R-HSA-9613829|reactome:R-HSA-9615710|reactome:R-HSA-9646399|rcsb pdb:4MNT|go:"GO:0006517"(protein deglycosylation)|go:"GO:0006914"(autophagy)|go:"GO:0006954"(inflammatory response)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007338"(single fertilization)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008233"(peptidase activity)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0009438"(methylglyoxal metabolic process)|go:"GO:0010273"(detoxification of copper ion)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016532"(superoxide dismutase copper chaperone activity)|go:"GO:0016570"(histone modification)|go:"GO:0016605"(PML body)|go:"GO:0016684"(oxidoreductase activity, acting on peroxide as acceptor)|go:"GO:0019249"(lactate biosynthetic process)|go:"GO:0019826"(oxygen sensor activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0019900"(kinase binding)|go:"GO:0019955"(cytokine binding)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0030424"(axon)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0032435"(negative regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0033182"(regulation of histone ubiquitination)|go:"GO:0033234"(negative regulation of protein sumoylation)|go:"GO:0033864"("positive regulation of NAD(P)H oxidase activity")|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0035065"(regulation of histone acetylation)|go:"GO:0036470"(tyrosine 3-monooxygenase activator activity)|go:"GO:0036471"(cellular response to glyoxal)|go:"GO:0036478"(L-dopa decarboxylase activator activity)|go:"GO:0036524"(protein deglycase activity)|go:"GO:0036526"(peptidyl-cysteine deglycation)|go:"GO:0036527"(peptidyl-arginine deglycation)|go:"GO:0036528"(peptidyl-lysine deglycation)|go:"GO:0036529"(protein deglycation, glyoxal removal)|go:"GO:0036530"(protein deglycation, methylglyoxal removal)|go:"GO:0036531"(glutathione deglycation)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042743"(hydrogen peroxide metabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043523"(regulation of neuron apoptotic process)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0044297"(cell body)|go:"GO:0030073"(insulin secretion)|go:"GO:0044388"(small protein activating enzyme binding)|go:"GO:0044390"(ubiquitin-like protein conjugating enzyme binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045296"(cadherin binding)|go:"GO:0045340"(mercury ion binding)|dip:DIP-35515N	-	-	-	figure legend:1F|comment:DJ-1 forms a complex with RACK1 possibly through C46 and C106 residues.|dataset:Parkinsons - Interactions investigated in the context of Parkinsons disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2014/07/02	2014/10/16	rogid:LXHlhPtxUzHJNncoPteGw2iXsFg9606	rogid:i5ah4UPCf+4cD51ClZNggMFJMDo9606	intact-crc:0FD72A6444CDF5A1|rigid:7hZDNZUn/lAKROROlxcT2+KAIF0	false	green fluorescent protein tag:?-?	flag tag:?-?|mutation disrupting interaction strength:46-46|mutation decreasing interaction strength:53-53|mutation disrupting interaction strength:106-106	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P63244	uniprotkb:P63244	intact:EBI-296739|ensembl:ENSP00000426909|uniprotkb:P25388|uniprotkb:P99049|intact:EBI-923003|uniprotkb:B3KTJ0|uniprotkb:Q53HU2|uniprotkb:Q5J8M6|uniprotkb:Q5VLR4|uniprotkb:Q6FH47|intact:EBI-2559282|uniprotkb:D3DWS0	intact:EBI-296739|ensembl:ENSP00000426909|uniprotkb:P25388|uniprotkb:P99049|intact:EBI-923003|uniprotkb:B3KTJ0|uniprotkb:Q53HU2|uniprotkb:Q5J8M6|uniprotkb:Q5VLR4|uniprotkb:Q6FH47|intact:EBI-2559282|uniprotkb:D3DWS0	psi-mi:rack1_human(display_long)|uniprotkb:Small ribosomal subunit protein RACK1(gene name synonym)|uniprotkb:HLC7(orf name)|uniprotkb:PIG21(orf name)|uniprotkb:RACK1(gene name)|psi-mi:RACK1(display_short)|uniprotkb:Cell proliferation-inducing gene 21 protein(gene name synonym)|uniprotkb:GNB2L1(gene name synonym)|uniprotkb:Guanine nucleotide-binding protein subunit beta-2-like 1(gene name synonym)|uniprotkb:Guanine nucleotide-binding protein subunit beta-like protein 12.3(gene name synonym)|uniprotkb:Human lung cancer oncogene 7 protein(gene name synonym)|uniprotkb:Receptor for activated C kinase(gene name synonym)	psi-mi:rack1_human(display_long)|uniprotkb:Small ribosomal subunit protein RACK1(gene name synonym)|uniprotkb:HLC7(orf name)|uniprotkb:PIG21(orf name)|uniprotkb:RACK1(gene name)|psi-mi:RACK1(display_short)|uniprotkb:Cell proliferation-inducing gene 21 protein(gene name synonym)|uniprotkb:GNB2L1(gene name synonym)|uniprotkb:Guanine nucleotide-binding protein subunit beta-2-like 1(gene name synonym)|uniprotkb:Guanine nucleotide-binding protein subunit beta-like protein 12.3(gene name synonym)|uniprotkb:Human lung cancer oncogene 7 protein(gene name synonym)|uniprotkb:Receptor for activated C kinase(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Ma et al. (2014)	imex:IM-23015|pubmed:24947010	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9685865|imex:IM-23015-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rcsb pdb:4AOW|rcsb pdb:4UG0|rcsb pdb:4V6X|rcsb pdb:5A2Q|rcsb pdb:5AJ0|rcsb pdb:5FLX|rcsb pdb:5LKS|rcsb pdb:5OA3|rcsb pdb:5T2C|rcsb pdb:5VYC|rcsb pdb:6EK0|mint:P63244|rcsb pdb:6FEC|rcsb pdb:6G18|rcsb pdb:6G51|rcsb pdb:6G53|rcsb pdb:6G5H|rcsb pdb:6G5I|rcsb pdb:6IP5|rcsb pdb:6IP6|rcsb pdb:6IP8|rcsb pdb:6OLE|rcsb pdb:6OLF|rcsb pdb:6OLG|rcsb pdb:6OLI|rcsb pdb:6OLZ|rcsb pdb:6OM0|rcsb pdb:6OM7|rcsb pdb:6QZP|rcsb pdb:6XA1|rcsb pdb:6Y0G|rcsb pdb:6Y2L|rcsb pdb:6Y57|rcsb pdb:6YBS|rcsb pdb:6Z6L|rcsb pdb:6Z6M|rcsb pdb:6Z6N|rcsb pdb:6ZLW|rcsb pdb:6ZM7|rcsb pdb:6ZME|rcsb pdb:6ZMI|rcsb pdb:6ZMO|rcsb pdb:6ZMT|rcsb pdb:6ZMW|rcsb pdb:6ZN5|rcsb pdb:6ZOJ|rcsb pdb:6ZOL|rcsb pdb:6ZON|rcsb pdb:6ZP4|ensembl:ENSG00000204628(gene)|ensembl:ENST00000512805(transcript)|go:"GO:0001891"(phagocytic cup)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007049"(cell cycle)|go:"GO:0007369"(gastrulation)|go:"GO:0008200"(ion channel inhibitor activity)|go:"GO:0008656"(cysteine-type endopeptidase activator activity involved in apoptotic process)|rcsb pdb:6ZV6|rcsb pdb:6ZVH|rcsb pdb:6ZVJ|rcsb pdb:6ZXD|rcsb pdb:6ZXE|rcsb pdb:6ZXF|rcsb pdb:6ZXG|rcsb pdb:6ZXH|rcsb pdb:7A09|rcsb pdb:7K5I|reactome:R-HSA-5357905|reactome:R-HSA-5357956|reactome:R-HSA-5626978|rcsb pdb:6ZUO|go:"GO:0015935"(small ribosomal subunit)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019899"(enzyme binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0030292"(protein tyrosine kinase inhibitor activity)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030332"(cyclin binding)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030425"(dendrite)|go:"GO:0030496"(midbody)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0033137"(negative regulation of peptidyl-serine phosphorylation)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043022"(ribosome binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0042998"(positive regulation of Golgi to plasma membrane protein transport)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043204"(perikaryon)|go:"GO:0043473"(pigmentation)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045296"(cadherin binding)|go:"GO:0045879"(negative regulation of smoothened signaling pathway)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048511"(rhythmic process)|go:"GO:0050765"(negative regulation of phagocytosis)|go:"GO:0051302"(regulation of cell division)|go:"GO:0051343"(positive regulation of cyclic-nucleotide phosphodiesterase activity)|go:"GO:0051434"(BH3 domain binding)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:0051901"(positive regulation of mitochondrial depolarization)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0072344"(rescue of stalled ribosome)|go:"GO:1900102"(negative regulation of endoplasmic reticulum unfolded protein response)|go:"GO:1903208"(negative regulation of hydrogen peroxide-induced neuron death)|go:"GO:1990630"(IRE1-RACK1-PP2A complex)|go:"GO:2000114"(regulation of establishment of cell polarity)|go:"GO:2000543"(positive regulation of gastrulation)|go:"GO:2001244"(positive regulation of intrinsic apoptotic signaling pathway)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR036322|go:"GO:0060090"(molecular adaptor activity)|refseq:NP_006089.1|dip:DIP-46736N	rcsb pdb:4AOW|rcsb pdb:4UG0|rcsb pdb:4V6X|rcsb pdb:5A2Q|rcsb pdb:5AJ0|rcsb pdb:5FLX|rcsb pdb:5LKS|rcsb pdb:5OA3|rcsb pdb:5T2C|rcsb pdb:5VYC|rcsb pdb:6EK0|mint:P63244|rcsb pdb:6FEC|rcsb pdb:6G18|rcsb pdb:6G51|rcsb pdb:6G53|rcsb pdb:6G5H|rcsb pdb:6G5I|rcsb pdb:6IP5|rcsb pdb:6IP6|rcsb pdb:6IP8|rcsb pdb:6OLE|rcsb pdb:6OLF|rcsb pdb:6OLG|rcsb pdb:6OLI|rcsb pdb:6OLZ|rcsb pdb:6OM0|rcsb pdb:6OM7|rcsb pdb:6QZP|rcsb pdb:6XA1|rcsb pdb:6Y0G|rcsb pdb:6Y2L|rcsb pdb:6Y57|rcsb pdb:6YBS|rcsb pdb:6Z6L|rcsb pdb:6Z6M|rcsb pdb:6Z6N|rcsb pdb:6ZLW|rcsb pdb:6ZM7|rcsb pdb:6ZME|rcsb pdb:6ZMI|rcsb pdb:6ZMO|rcsb pdb:6ZMT|rcsb pdb:6ZMW|rcsb pdb:6ZN5|rcsb pdb:6ZOJ|rcsb pdb:6ZOL|rcsb pdb:6ZON|rcsb pdb:6ZP4|ensembl:ENSG00000204628(gene)|ensembl:ENST00000512805(transcript)|go:"GO:0001891"(phagocytic cup)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007049"(cell cycle)|go:"GO:0007369"(gastrulation)|go:"GO:0008200"(ion channel inhibitor activity)|go:"GO:0008656"(cysteine-type endopeptidase activator activity involved in apoptotic process)|rcsb pdb:6ZV6|rcsb pdb:6ZVH|rcsb pdb:6ZVJ|rcsb pdb:6ZXD|rcsb pdb:6ZXE|rcsb pdb:6ZXF|rcsb pdb:6ZXG|rcsb pdb:6ZXH|rcsb pdb:7A09|rcsb pdb:7K5I|reactome:R-HSA-5357905|reactome:R-HSA-5357956|reactome:R-HSA-5626978|rcsb pdb:6ZUO|go:"GO:0015935"(small ribosomal subunit)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019899"(enzyme binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0030292"(protein tyrosine kinase inhibitor activity)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030332"(cyclin binding)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030425"(dendrite)|go:"GO:0030496"(midbody)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0033137"(negative regulation of peptidyl-serine phosphorylation)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043022"(ribosome binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0042998"(positive regulation of Golgi to plasma membrane protein transport)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043204"(perikaryon)|go:"GO:0043473"(pigmentation)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045296"(cadherin binding)|go:"GO:0045879"(negative regulation of smoothened signaling pathway)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048511"(rhythmic process)|go:"GO:0050765"(negative regulation of phagocytosis)|go:"GO:0051302"(regulation of cell division)|go:"GO:0051343"(positive regulation of cyclic-nucleotide phosphodiesterase activity)|go:"GO:0051434"(BH3 domain binding)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:0051901"(positive regulation of mitochondrial depolarization)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0072344"(rescue of stalled ribosome)|go:"GO:1900102"(negative regulation of endoplasmic reticulum unfolded protein response)|go:"GO:1903208"(negative regulation of hydrogen peroxide-induced neuron death)|go:"GO:1990630"(IRE1-RACK1-PP2A complex)|go:"GO:2000114"(regulation of establishment of cell polarity)|go:"GO:2000543"(positive regulation of gastrulation)|go:"GO:2001244"(positive regulation of intrinsic apoptotic signaling pathway)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR036322|go:"GO:0060090"(molecular adaptor activity)|refseq:NP_006089.1|dip:DIP-46736N	-	-	-	figure legend:2C|agonist:"DJ-1 expression enhanced the  homodimerisation of RACK1, (whereas the  dimerization of DJ-1 was not affected by RACK1)."|dataset:Parkinsons - Interactions investigated in the context of Parkinsons disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2014/07/02	2014/10/16	rogid:LXHlhPtxUzHJNncoPteGw2iXsFg9606	rogid:LXHlhPtxUzHJNncoPteGw2iXsFg9606	intact-crc:5886A03052446DF5|rigid:IY1TNKvKUUtwEA1PNlXepjg5TcY	false	flag tag:?-?	green fluorescent protein tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q99497	uniprotkb:Q99497	intact:EBI-1164361|uniprotkb:O14805|uniprotkb:Q6DR95|uniprotkb:Q7LFU2|uniprotkb:B2R4Z1|ensembl:ENSP00000340278|ensembl:ENSP00000366708|ensembl:ENSP00000366711|ensembl:ENSP00000418770|ensembl:ENSP00000465404	intact:EBI-1164361|uniprotkb:O14805|uniprotkb:Q6DR95|uniprotkb:Q7LFU2|uniprotkb:B2R4Z1|ensembl:ENSP00000340278|ensembl:ENSP00000366708|ensembl:ENSP00000366711|ensembl:ENSP00000418770|ensembl:ENSP00000465404	psi-mi:park7_human(display_long)|uniprotkb:PARK7(gene name)|psi-mi:PARK7(display_short)|uniprotkb:Oncogene DJ1(gene name synonym)|uniprotkb:Parkinsonism-associated deglycase(gene name synonym)|uniprotkb:Maillard deglycase(gene name synonym)|uniprotkb:Protein DJ-1(gene name synonym)|uniprotkb:Protein/nucleic acid deglycase DJ-1(gene name synonym)	psi-mi:park7_human(display_long)|uniprotkb:PARK7(gene name)|psi-mi:PARK7(display_short)|uniprotkb:Oncogene DJ1(gene name synonym)|uniprotkb:Parkinsonism-associated deglycase(gene name synonym)|uniprotkb:Maillard deglycase(gene name synonym)|uniprotkb:Protein DJ-1(gene name synonym)|uniprotkb:Protein/nucleic acid deglycase DJ-1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Ma et al. (2014)	imex:IM-23015|pubmed:24947010	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9685874|imex:IM-23015-8	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001116849.1|refseq:NP_009193.2|refseq:XP_005263481.1|go:"GO:0046295"(glycolate biosynthetic process)|go:"GO:0046826"(negative regulation of protein export from nucleus)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050681"(androgen receptor binding)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050787"(detoxification of mercury ion)|go:"GO:0050821"(protein stabilization)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051444"(negative regulation of ubiquitin-protein transferase activity)|go:"GO:0051583"(dopamine uptake involved in synaptic transmission)|go:"GO:0051881"(regulation of mitochondrial membrane potential)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051899"(membrane depolarization)|go:"GO:0051920"(peroxiredoxin activity)|go:"GO:0060081"(membrane hyperpolarization)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0060765"(regulation of androgen receptor signaling pathway)|go:"GO:0061727"(methylglyoxal catabolic process to lactate)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070994"(detection of oxidative stress)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098793"(presynapse)|go:"GO:0106044"(guanine deglycation)|go:"GO:0106045"(guanine deglycation, methylglyoxal removal)|go:"GO:0106046"(guanine deglycation, glyoxal removal)|go:"GO:0110095"(cellular detoxification of aldehyde)|go:"GO:0140041"(cellular detoxification of methylglyoxal)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1901671"(positive regulation of superoxide dismutase activity)|go:"GO:1901984"(negative regulation of protein acetylation)|go:"GO:1902177"(positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1902236"(negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1902903"(regulation of supramolecular fiber organization)|go:"GO:1902958"(positive regulation of mitochondrial electron transport, NADH to ubiquinone)|go:"GO:1903073"(negative regulation of death-inducing signaling complex assembly)|go:"GO:1903094"(negative regulation of protein K48-linked deubiquitination)|go:"GO:1903122"(negative regulation of TRAIL-activated apoptotic signaling pathway)|go:"GO:1903135"(cupric ion binding)|go:"GO:1903136"(cuprous ion binding)|go:"GO:1903168"(positive regulation of pyrroline-5-carboxylate reductase activity)|go:"GO:1903178"(positive regulation of tyrosine 3-monooxygenase activity)|go:"GO:1903181"(positive regulation of dopamine biosynthetic process)|go:"GO:1903189"(glyoxal metabolic process)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:1903200"(positive regulation of L-dopa decarboxylase activity)|go:"GO:1903202"(negative regulation of oxidative stress-induced cell death)|go:"GO:1903206"(negative regulation of hydrogen peroxide-induced cell death)|go:"GO:1903208"(negative regulation of hydrogen peroxide-induced neuron death)|go:"GO:1903377"(negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway)|go:"GO:1903384"(negative regulation of hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway)|go:"GO:1903427"(negative regulation of reactive oxygen species biosynthetic process)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1903599"(positive regulation of autophagy of mitochondrion)|go:"GO:1905259"(negative regulation of nitrosative stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1990381"(ubiquitin-specific protease binding)|go:"GO:1990422"("glyoxalase (glycolic acid-forming) activity")|go:"GO:2000157"(negative regulation of ubiquitin-specific protease activity)|go:"GO:2000277"(positive regulation of oxidative phosphorylation uncoupler activity)|go:"GO:2000679"(positive regulation of transcription regulatory region DNA binding)|go:"GO:2000825"(positive regulation of androgen receptor activity)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|go:"GO:2001268"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|interpro:IPR002818(ThiJ/PfpI)|interpro:IPR006287(DJ-1)|interpro:IPR029062|go:"GO:1903197"(positive regulation of L-dopa biosynthetic process)|rcsb pdb:3B36|rcsb pdb:3B38|rcsb pdb:3B3A|rcsb pdb:3BWE|rcsb pdb:3CY6|rcsb pdb:3CYF|rcsb pdb:3CZ9|rcsb pdb:3CZA|rcsb pdb:3EZG|mint:Q99497|rcsb pdb:1J42|rcsb pdb:1P5F|rcsb pdb:3F71|rcsb pdb:1PDV|rcsb pdb:1PDW|rcsb pdb:1PE0|rcsb pdb:1Q2U|rcsb pdb:3SF8|rcsb pdb:1SOA|rcsb pdb:1UCF|rcsb pdb:2OR3|rcsb pdb:2R1T|rcsb pdb:2R1U|rcsb pdb:2R1V|rcsb pdb:4BTE|rcsb pdb:2RK3|rcsb pdb:2RK4|rcsb pdb:2RK6|ensembl:ENSG00000116288(gene)|ensembl:ENST00000338639(transcript)|ensembl:ENST00000377488(transcript)|ensembl:ENST00000377491(transcript)|ensembl:ENST00000493678(transcript)|ensembl:ENST00000493373(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0002866"(positive regulation of acute inflammatory response to antigenic stimulus)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003729"(mRNA binding)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005507"(copper ion binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0006281"(DNA repair)|rcsb pdb:4MTC|rcsb pdb:4N0M|rcsb pdb:4N12|rcsb pdb:4OGF|rcsb pdb:4OQ4|rcsb pdb:4P2G|rcsb pdb:4P34|rcsb pdb:4P35|rcsb pdb:4P36|rcsb pdb:4RKW|rcsb pdb:4RKY|rcsb pdb:4S0Z|rcsb pdb:4ZGG|rcsb pdb:5IP5|rcsb pdb:5SY6|rcsb pdb:5SY9|rcsb pdb:5SYA|rcsb pdb:6AF5|rcsb pdb:6AF7|rcsb pdb:6AF9|rcsb pdb:6AFA|rcsb pdb:6AFB|rcsb pdb:6AFC|rcsb pdb:6AFD|rcsb pdb:6AFE|rcsb pdb:6AFF|rcsb pdb:6AFG|rcsb pdb:6AFH|rcsb pdb:6AFI|rcsb pdb:6AFJ|rcsb pdb:6AFL|rcsb pdb:6E5Z|rcsb pdb:6M8Z|rcsb pdb:7C62|reactome:R-HSA-3899300|reactome:R-HSA-9613829|reactome:R-HSA-9615710|reactome:R-HSA-9646399|rcsb pdb:4MNT|go:"GO:0006517"(protein deglycosylation)|go:"GO:0006914"(autophagy)|go:"GO:0006954"(inflammatory response)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007338"(single fertilization)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008233"(peptidase activity)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0009438"(methylglyoxal metabolic process)|go:"GO:0010273"(detoxification of copper ion)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016532"(superoxide dismutase copper chaperone activity)|go:"GO:0016570"(histone modification)|go:"GO:0016605"(PML body)|go:"GO:0016684"(oxidoreductase activity, acting on peroxide as acceptor)|go:"GO:0019249"(lactate biosynthetic process)|go:"GO:0019826"(oxygen sensor activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0019900"(kinase binding)|go:"GO:0019955"(cytokine binding)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0030424"(axon)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0032435"(negative regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0033182"(regulation of histone ubiquitination)|go:"GO:0033234"(negative regulation of protein sumoylation)|go:"GO:0033864"("positive regulation of NAD(P)H oxidase activity")|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0035065"(regulation of histone acetylation)|go:"GO:0036470"(tyrosine 3-monooxygenase activator activity)|go:"GO:0036471"(cellular response to glyoxal)|go:"GO:0036478"(L-dopa decarboxylase activator activity)|go:"GO:0036524"(protein deglycase activity)|go:"GO:0036526"(peptidyl-cysteine deglycation)|go:"GO:0036527"(peptidyl-arginine deglycation)|go:"GO:0036528"(peptidyl-lysine deglycation)|go:"GO:0036529"(protein deglycation, glyoxal removal)|go:"GO:0036530"(protein deglycation, methylglyoxal removal)|go:"GO:0036531"(glutathione deglycation)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042743"(hydrogen peroxide metabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043523"(regulation of neuron apoptotic process)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0044297"(cell body)|go:"GO:0030073"(insulin secretion)|go:"GO:0044388"(small protein activating enzyme binding)|go:"GO:0044390"(ubiquitin-like protein conjugating enzyme binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045296"(cadherin binding)|go:"GO:0045340"(mercury ion binding)|dip:DIP-35515N	refseq:NP_001116849.1|refseq:NP_009193.2|refseq:XP_005263481.1|go:"GO:0046295"(glycolate biosynthetic process)|go:"GO:0046826"(negative regulation of protein export from nucleus)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050681"(androgen receptor binding)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050787"(detoxification of mercury ion)|go:"GO:0050821"(protein stabilization)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051444"(negative regulation of ubiquitin-protein transferase activity)|go:"GO:0051583"(dopamine uptake involved in synaptic transmission)|go:"GO:0051881"(regulation of mitochondrial membrane potential)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051899"(membrane depolarization)|go:"GO:0051920"(peroxiredoxin activity)|go:"GO:0060081"(membrane hyperpolarization)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0060765"(regulation of androgen receptor signaling pathway)|go:"GO:0061727"(methylglyoxal catabolic process to lactate)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070994"(detection of oxidative stress)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098793"(presynapse)|go:"GO:0106044"(guanine deglycation)|go:"GO:0106045"(guanine deglycation, methylglyoxal removal)|go:"GO:0106046"(guanine deglycation, glyoxal removal)|go:"GO:0110095"(cellular detoxification of aldehyde)|go:"GO:0140041"(cellular detoxification of methylglyoxal)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1901671"(positive regulation of superoxide dismutase activity)|go:"GO:1901984"(negative regulation of protein acetylation)|go:"GO:1902177"(positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1902236"(negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1902903"(regulation of supramolecular fiber organization)|go:"GO:1902958"(positive regulation of mitochondrial electron transport, NADH to ubiquinone)|go:"GO:1903073"(negative regulation of death-inducing signaling complex assembly)|go:"GO:1903094"(negative regulation of protein K48-linked deubiquitination)|go:"GO:1903122"(negative regulation of TRAIL-activated apoptotic signaling pathway)|go:"GO:1903135"(cupric ion binding)|go:"GO:1903136"(cuprous ion binding)|go:"GO:1903168"(positive regulation of pyrroline-5-carboxylate reductase activity)|go:"GO:1903178"(positive regulation of tyrosine 3-monooxygenase activity)|go:"GO:1903181"(positive regulation of dopamine biosynthetic process)|go:"GO:1903189"(glyoxal metabolic process)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:1903200"(positive regulation of L-dopa decarboxylase activity)|go:"GO:1903202"(negative regulation of oxidative stress-induced cell death)|go:"GO:1903206"(negative regulation of hydrogen peroxide-induced cell death)|go:"GO:1903208"(negative regulation of hydrogen peroxide-induced neuron death)|go:"GO:1903377"(negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway)|go:"GO:1903384"(negative regulation of hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway)|go:"GO:1903427"(negative regulation of reactive oxygen species biosynthetic process)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1903599"(positive regulation of autophagy of mitochondrion)|go:"GO:1905259"(negative regulation of nitrosative stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1990381"(ubiquitin-specific protease binding)|go:"GO:1990422"("glyoxalase (glycolic acid-forming) activity")|go:"GO:2000157"(negative regulation of ubiquitin-specific protease activity)|go:"GO:2000277"(positive regulation of oxidative phosphorylation uncoupler activity)|go:"GO:2000679"(positive regulation of transcription regulatory region DNA binding)|go:"GO:2000825"(positive regulation of androgen receptor activity)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|go:"GO:2001268"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|interpro:IPR002818(ThiJ/PfpI)|interpro:IPR006287(DJ-1)|interpro:IPR029062|go:"GO:1903197"(positive regulation of L-dopa biosynthetic process)|rcsb pdb:3B36|rcsb pdb:3B38|rcsb pdb:3B3A|rcsb pdb:3BWE|rcsb pdb:3CY6|rcsb pdb:3CYF|rcsb pdb:3CZ9|rcsb pdb:3CZA|rcsb pdb:3EZG|mint:Q99497|rcsb pdb:1J42|rcsb pdb:1P5F|rcsb pdb:3F71|rcsb pdb:1PDV|rcsb pdb:1PDW|rcsb pdb:1PE0|rcsb pdb:1Q2U|rcsb pdb:3SF8|rcsb pdb:1SOA|rcsb pdb:1UCF|rcsb pdb:2OR3|rcsb pdb:2R1T|rcsb pdb:2R1U|rcsb pdb:2R1V|rcsb pdb:4BTE|rcsb pdb:2RK3|rcsb pdb:2RK4|rcsb pdb:2RK6|ensembl:ENSG00000116288(gene)|ensembl:ENST00000338639(transcript)|ensembl:ENST00000377488(transcript)|ensembl:ENST00000377491(transcript)|ensembl:ENST00000493678(transcript)|ensembl:ENST00000493373(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0002866"(positive regulation of acute inflammatory response to antigenic stimulus)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003729"(mRNA binding)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005507"(copper ion binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0006281"(DNA repair)|rcsb pdb:4MTC|rcsb pdb:4N0M|rcsb pdb:4N12|rcsb pdb:4OGF|rcsb pdb:4OQ4|rcsb pdb:4P2G|rcsb pdb:4P34|rcsb pdb:4P35|rcsb pdb:4P36|rcsb pdb:4RKW|rcsb pdb:4RKY|rcsb pdb:4S0Z|rcsb pdb:4ZGG|rcsb pdb:5IP5|rcsb pdb:5SY6|rcsb pdb:5SY9|rcsb pdb:5SYA|rcsb pdb:6AF5|rcsb pdb:6AF7|rcsb pdb:6AF9|rcsb pdb:6AFA|rcsb pdb:6AFB|rcsb pdb:6AFC|rcsb pdb:6AFD|rcsb pdb:6AFE|rcsb pdb:6AFF|rcsb pdb:6AFG|rcsb pdb:6AFH|rcsb pdb:6AFI|rcsb pdb:6AFJ|rcsb pdb:6AFL|rcsb pdb:6E5Z|rcsb pdb:6M8Z|rcsb pdb:7C62|reactome:R-HSA-3899300|reactome:R-HSA-9613829|reactome:R-HSA-9615710|reactome:R-HSA-9646399|rcsb pdb:4MNT|go:"GO:0006517"(protein deglycosylation)|go:"GO:0006914"(autophagy)|go:"GO:0006954"(inflammatory response)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007338"(single fertilization)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008233"(peptidase activity)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0009438"(methylglyoxal metabolic process)|go:"GO:0010273"(detoxification of copper ion)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016532"(superoxide dismutase copper chaperone activity)|go:"GO:0016570"(histone modification)|go:"GO:0016605"(PML body)|go:"GO:0016684"(oxidoreductase activity, acting on peroxide as acceptor)|go:"GO:0019249"(lactate biosynthetic process)|go:"GO:0019826"(oxygen sensor activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0019900"(kinase binding)|go:"GO:0019955"(cytokine binding)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0030424"(axon)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0032435"(negative regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0033182"(regulation of histone ubiquitination)|go:"GO:0033234"(negative regulation of protein sumoylation)|go:"GO:0033864"("positive regulation of NAD(P)H oxidase activity")|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0035065"(regulation of histone acetylation)|go:"GO:0036470"(tyrosine 3-monooxygenase activator activity)|go:"GO:0036471"(cellular response to glyoxal)|go:"GO:0036478"(L-dopa decarboxylase activator activity)|go:"GO:0036524"(protein deglycase activity)|go:"GO:0036526"(peptidyl-cysteine deglycation)|go:"GO:0036527"(peptidyl-arginine deglycation)|go:"GO:0036528"(peptidyl-lysine deglycation)|go:"GO:0036529"(protein deglycation, glyoxal removal)|go:"GO:0036530"(protein deglycation, methylglyoxal removal)|go:"GO:0036531"(glutathione deglycation)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042743"(hydrogen peroxide metabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043523"(regulation of neuron apoptotic process)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0044297"(cell body)|go:"GO:0030073"(insulin secretion)|go:"GO:0044388"(small protein activating enzyme binding)|go:"GO:0044390"(ubiquitin-like protein conjugating enzyme binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045296"(cadherin binding)|go:"GO:0045340"(mercury ion binding)|dip:DIP-35515N	-	-	-	figure legend:2D|comment:"Only a  faint band is ever visible when blotting with anti-GFP.  The dimerization of DJ-1 was not affected by RACK1, (whereas DJ-1 expression did enhance the homodimerisation of RACK1.)"|dataset:Parkinsons - Interactions investigated in the context of Parkinsons disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2014/07/02	2014/10/16	rogid:i5ah4UPCf+4cD51ClZNggMFJMDo9606	rogid:i5ah4UPCf+4cD51ClZNggMFJMDo9606	intact-crc:25D4F7F49DB2C9CA|rigid:UFwHr+tSuPcNjIOgNVS8vTjiHs4	false	green fluorescent protein tag:?-?	myc tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P63244	uniprotkb:Q99497	intact:EBI-296739|ensembl:ENSP00000426909|uniprotkb:P25388|uniprotkb:P99049|intact:EBI-923003|uniprotkb:B3KTJ0|uniprotkb:Q53HU2|uniprotkb:Q5J8M6|uniprotkb:Q5VLR4|uniprotkb:Q6FH47|intact:EBI-2559282|uniprotkb:D3DWS0	intact:EBI-1164361|uniprotkb:O14805|uniprotkb:Q6DR95|uniprotkb:Q7LFU2|uniprotkb:B2R4Z1|ensembl:ENSP00000340278|ensembl:ENSP00000366708|ensembl:ENSP00000366711|ensembl:ENSP00000418770|ensembl:ENSP00000465404	psi-mi:rack1_human(display_long)|uniprotkb:Small ribosomal subunit protein RACK1(gene name synonym)|uniprotkb:HLC7(orf name)|uniprotkb:PIG21(orf name)|uniprotkb:RACK1(gene name)|psi-mi:RACK1(display_short)|uniprotkb:Cell proliferation-inducing gene 21 protein(gene name synonym)|uniprotkb:GNB2L1(gene name synonym)|uniprotkb:Guanine nucleotide-binding protein subunit beta-2-like 1(gene name synonym)|uniprotkb:Guanine nucleotide-binding protein subunit beta-like protein 12.3(gene name synonym)|uniprotkb:Human lung cancer oncogene 7 protein(gene name synonym)|uniprotkb:Receptor for activated C kinase(gene name synonym)	psi-mi:park7_human(display_long)|uniprotkb:PARK7(gene name)|psi-mi:PARK7(display_short)|uniprotkb:Oncogene DJ1(gene name synonym)|uniprotkb:Parkinsonism-associated deglycase(gene name synonym)|uniprotkb:Maillard deglycase(gene name synonym)|uniprotkb:Protein DJ-1(gene name synonym)|uniprotkb:Protein/nucleic acid deglycase DJ-1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Ma et al. (2014)	imex:IM-23015|pubmed:24947010	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9685793|imex:IM-23015-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rcsb pdb:4AOW|rcsb pdb:4UG0|rcsb pdb:4V6X|rcsb pdb:5A2Q|rcsb pdb:5AJ0|rcsb pdb:5FLX|rcsb pdb:5LKS|rcsb pdb:5OA3|rcsb pdb:5T2C|rcsb pdb:5VYC|rcsb pdb:6EK0|mint:P63244|rcsb pdb:6FEC|rcsb pdb:6G18|rcsb pdb:6G51|rcsb pdb:6G53|rcsb pdb:6G5H|rcsb pdb:6G5I|rcsb pdb:6IP5|rcsb pdb:6IP6|rcsb pdb:6IP8|rcsb pdb:6OLE|rcsb pdb:6OLF|rcsb pdb:6OLG|rcsb pdb:6OLI|rcsb pdb:6OLZ|rcsb pdb:6OM0|rcsb pdb:6OM7|rcsb pdb:6QZP|rcsb pdb:6XA1|rcsb pdb:6Y0G|rcsb pdb:6Y2L|rcsb pdb:6Y57|rcsb pdb:6YBS|rcsb pdb:6Z6L|rcsb pdb:6Z6M|rcsb pdb:6Z6N|rcsb pdb:6ZLW|rcsb pdb:6ZM7|rcsb pdb:6ZME|rcsb pdb:6ZMI|rcsb pdb:6ZMO|rcsb pdb:6ZMT|rcsb pdb:6ZMW|rcsb pdb:6ZN5|rcsb pdb:6ZOJ|rcsb pdb:6ZOL|rcsb pdb:6ZON|rcsb pdb:6ZP4|ensembl:ENSG00000204628(gene)|ensembl:ENST00000512805(transcript)|go:"GO:0001891"(phagocytic cup)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007049"(cell cycle)|go:"GO:0007369"(gastrulation)|go:"GO:0008200"(ion channel inhibitor activity)|go:"GO:0008656"(cysteine-type endopeptidase activator activity involved in apoptotic process)|rcsb pdb:6ZV6|rcsb pdb:6ZVH|rcsb pdb:6ZVJ|rcsb pdb:6ZXD|rcsb pdb:6ZXE|rcsb pdb:6ZXF|rcsb pdb:6ZXG|rcsb pdb:6ZXH|rcsb pdb:7A09|rcsb pdb:7K5I|reactome:R-HSA-5357905|reactome:R-HSA-5357956|reactome:R-HSA-5626978|rcsb pdb:6ZUO|go:"GO:0015935"(small ribosomal subunit)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019899"(enzyme binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0030292"(protein tyrosine kinase inhibitor activity)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030332"(cyclin binding)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030425"(dendrite)|go:"GO:0030496"(midbody)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0033137"(negative regulation of peptidyl-serine phosphorylation)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043022"(ribosome binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0042998"(positive regulation of Golgi to plasma membrane protein transport)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043204"(perikaryon)|go:"GO:0043473"(pigmentation)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045296"(cadherin binding)|go:"GO:0045879"(negative regulation of smoothened signaling pathway)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048511"(rhythmic process)|go:"GO:0050765"(negative regulation of phagocytosis)|go:"GO:0051302"(regulation of cell division)|go:"GO:0051343"(positive regulation of cyclic-nucleotide phosphodiesterase activity)|go:"GO:0051434"(BH3 domain binding)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:0051901"(positive regulation of mitochondrial depolarization)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0072344"(rescue of stalled ribosome)|go:"GO:1900102"(negative regulation of endoplasmic reticulum unfolded protein response)|go:"GO:1903208"(negative regulation of hydrogen peroxide-induced neuron death)|go:"GO:1990630"(IRE1-RACK1-PP2A complex)|go:"GO:2000114"(regulation of establishment of cell polarity)|go:"GO:2000543"(positive regulation of gastrulation)|go:"GO:2001244"(positive regulation of intrinsic apoptotic signaling pathway)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR036322|go:"GO:0060090"(molecular adaptor activity)|refseq:NP_006089.1|dip:DIP-46736N	refseq:NP_001116849.1|refseq:NP_009193.2|refseq:XP_005263481.1|go:"GO:0046295"(glycolate biosynthetic process)|go:"GO:0046826"(negative regulation of protein export from nucleus)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050681"(androgen receptor binding)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050787"(detoxification of mercury ion)|go:"GO:0050821"(protein stabilization)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051444"(negative regulation of ubiquitin-protein transferase activity)|go:"GO:0051583"(dopamine uptake involved in synaptic transmission)|go:"GO:0051881"(regulation of mitochondrial membrane potential)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051899"(membrane depolarization)|go:"GO:0051920"(peroxiredoxin activity)|go:"GO:0060081"(membrane hyperpolarization)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0060765"(regulation of androgen receptor signaling pathway)|go:"GO:0061727"(methylglyoxal catabolic process to lactate)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070994"(detection of oxidative stress)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098793"(presynapse)|go:"GO:0106044"(guanine deglycation)|go:"GO:0106045"(guanine deglycation, methylglyoxal removal)|go:"GO:0106046"(guanine deglycation, glyoxal removal)|go:"GO:0110095"(cellular detoxification of aldehyde)|go:"GO:0140041"(cellular detoxification of methylglyoxal)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1901671"(positive regulation of superoxide dismutase activity)|go:"GO:1901984"(negative regulation of protein acetylation)|go:"GO:1902177"(positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1902236"(negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1902903"(regulation of supramolecular fiber organization)|go:"GO:1902958"(positive regulation of mitochondrial electron transport, NADH to ubiquinone)|go:"GO:1903073"(negative regulation of death-inducing signaling complex assembly)|go:"GO:1903094"(negative regulation of protein K48-linked deubiquitination)|go:"GO:1903122"(negative regulation of TRAIL-activated apoptotic signaling pathway)|go:"GO:1903135"(cupric ion binding)|go:"GO:1903136"(cuprous ion binding)|go:"GO:1903168"(positive regulation of pyrroline-5-carboxylate reductase activity)|go:"GO:1903178"(positive regulation of tyrosine 3-monooxygenase activity)|go:"GO:1903181"(positive regulation of dopamine biosynthetic process)|go:"GO:1903189"(glyoxal metabolic process)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:1903200"(positive regulation of L-dopa decarboxylase activity)|go:"GO:1903202"(negative regulation of oxidative stress-induced cell death)|go:"GO:1903206"(negative regulation of hydrogen peroxide-induced cell death)|go:"GO:1903208"(negative regulation of hydrogen peroxide-induced neuron death)|go:"GO:1903377"(negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway)|go:"GO:1903384"(negative regulation of hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway)|go:"GO:1903427"(negative regulation of reactive oxygen species biosynthetic process)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1903599"(positive regulation of autophagy of mitochondrion)|go:"GO:1905259"(negative regulation of nitrosative stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1990381"(ubiquitin-specific protease binding)|go:"GO:1990422"("glyoxalase (glycolic acid-forming) activity")|go:"GO:2000157"(negative regulation of ubiquitin-specific protease activity)|go:"GO:2000277"(positive regulation of oxidative phosphorylation uncoupler activity)|go:"GO:2000679"(positive regulation of transcription regulatory region DNA binding)|go:"GO:2000825"(positive regulation of androgen receptor activity)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|go:"GO:2001268"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|interpro:IPR002818(ThiJ/PfpI)|interpro:IPR006287(DJ-1)|interpro:IPR029062|go:"GO:1903197"(positive regulation of L-dopa biosynthetic process)|rcsb pdb:3B36|rcsb pdb:3B38|rcsb pdb:3B3A|rcsb pdb:3BWE|rcsb pdb:3CY6|rcsb pdb:3CYF|rcsb pdb:3CZ9|rcsb pdb:3CZA|rcsb pdb:3EZG|mint:Q99497|rcsb pdb:1J42|rcsb pdb:1P5F|rcsb pdb:3F71|rcsb pdb:1PDV|rcsb pdb:1PDW|rcsb pdb:1PE0|rcsb pdb:1Q2U|rcsb pdb:3SF8|rcsb pdb:1SOA|rcsb pdb:1UCF|rcsb pdb:2OR3|rcsb pdb:2R1T|rcsb pdb:2R1U|rcsb pdb:2R1V|rcsb pdb:4BTE|rcsb pdb:2RK3|rcsb pdb:2RK4|rcsb pdb:2RK6|ensembl:ENSG00000116288(gene)|ensembl:ENST00000338639(transcript)|ensembl:ENST00000377488(transcript)|ensembl:ENST00000377491(transcript)|ensembl:ENST00000493678(transcript)|ensembl:ENST00000493373(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0002866"(positive regulation of acute inflammatory response to antigenic stimulus)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003729"(mRNA binding)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005507"(copper ion binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0006281"(DNA repair)|rcsb pdb:4MTC|rcsb pdb:4N0M|rcsb pdb:4N12|rcsb pdb:4OGF|rcsb pdb:4OQ4|rcsb pdb:4P2G|rcsb pdb:4P34|rcsb pdb:4P35|rcsb pdb:4P36|rcsb pdb:4RKW|rcsb pdb:4RKY|rcsb pdb:4S0Z|rcsb pdb:4ZGG|rcsb pdb:5IP5|rcsb pdb:5SY6|rcsb pdb:5SY9|rcsb pdb:5SYA|rcsb pdb:6AF5|rcsb pdb:6AF7|rcsb pdb:6AF9|rcsb pdb:6AFA|rcsb pdb:6AFB|rcsb pdb:6AFC|rcsb pdb:6AFD|rcsb pdb:6AFE|rcsb pdb:6AFF|rcsb pdb:6AFG|rcsb pdb:6AFH|rcsb pdb:6AFI|rcsb pdb:6AFJ|rcsb pdb:6AFL|rcsb pdb:6E5Z|rcsb pdb:6M8Z|rcsb pdb:7C62|reactome:R-HSA-3899300|reactome:R-HSA-9613829|reactome:R-HSA-9615710|reactome:R-HSA-9646399|rcsb pdb:4MNT|go:"GO:0006517"(protein deglycosylation)|go:"GO:0006914"(autophagy)|go:"GO:0006954"(inflammatory response)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007338"(single fertilization)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008233"(peptidase activity)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0009438"(methylglyoxal metabolic process)|go:"GO:0010273"(detoxification of copper ion)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016532"(superoxide dismutase copper chaperone activity)|go:"GO:0016570"(histone modification)|go:"GO:0016605"(PML body)|go:"GO:0016684"(oxidoreductase activity, acting on peroxide as acceptor)|go:"GO:0019249"(lactate biosynthetic process)|go:"GO:0019826"(oxygen sensor activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0019900"(kinase binding)|go:"GO:0019955"(cytokine binding)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0030424"(axon)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0032435"(negative regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0033182"(regulation of histone ubiquitination)|go:"GO:0033234"(negative regulation of protein sumoylation)|go:"GO:0033864"("positive regulation of NAD(P)H oxidase activity")|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0035065"(regulation of histone acetylation)|go:"GO:0036470"(tyrosine 3-monooxygenase activator activity)|go:"GO:0036471"(cellular response to glyoxal)|go:"GO:0036478"(L-dopa decarboxylase activator activity)|go:"GO:0036524"(protein deglycase activity)|go:"GO:0036526"(peptidyl-cysteine deglycation)|go:"GO:0036527"(peptidyl-arginine deglycation)|go:"GO:0036528"(peptidyl-lysine deglycation)|go:"GO:0036529"(protein deglycation, glyoxal removal)|go:"GO:0036530"(protein deglycation, methylglyoxal removal)|go:"GO:0036531"(glutathione deglycation)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042743"(hydrogen peroxide metabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043523"(regulation of neuron apoptotic process)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0044297"(cell body)|go:"GO:0030073"(insulin secretion)|go:"GO:0044388"(small protein activating enzyme binding)|go:"GO:0044390"(ubiquitin-like protein conjugating enzyme binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045296"(cadherin binding)|go:"GO:0045340"(mercury ion binding)|dip:DIP-35515N	-	-	-	figure legend:1B|dataset:Parkinsons - Interactions investigated in the context of Parkinsons disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2014/07/02	2014/10/16	rogid:LXHlhPtxUzHJNncoPteGw2iXsFg9606	rogid:i5ah4UPCf+4cD51ClZNggMFJMDo9606	intact-crc:C0700DE2828F435D|rigid:7hZDNZUn/lAKROROlxcT2+KAIF0	false	flag tag:?-?	green fluorescent protein tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P68040	uniprotkb:Q99LX0	intact:EBI-296749|ensembl:ENSMUSP00000020640|uniprotkb:P25388|uniprotkb:P99049|intact:EBI-1183965|uniprotkb:Q3THP0|uniprotkb:Q3THY7|uniprotkb:Q3TKQ0|uniprotkb:Q3TW88|uniprotkb:Q5NCC5|uniprotkb:Q5NCC6|uniprotkb:Q9CSQ0|uniprotkb:Q9ERM6	intact:EBI-1634273|uniprotkb:O88306|uniprotkb:Q3THB9|uniprotkb:Q3U509|ensembl:ENSMUSP00000030805|ensembl:ENSMUSP00000101298|ensembl:ENSMUSP00000101299|ensembl:ENSMUSP00000101300	psi-mi:rack1_mouse(display_long)|uniprotkb:p205(gene name synonym)|uniprotkb:Receptor of activated protein kinase C 1(gene name synonym)|uniprotkb:12-3(gene name synonym)|uniprotkb:Gnb2-rs1(gene name synonym)|uniprotkb:Gnb2l1(gene name synonym)|uniprotkb:Guanine nucleotide-binding protein subunit beta-2-like 1(gene name synonym)|uniprotkb:Rack1(gene name)|psi-mi:Rack1(display_short)|uniprotkb:Receptor for activated C kinase(gene name synonym)	psi-mi:park7_mouse(display_long)|uniprotkb:Park7(gene name)|psi-mi:Park7(display_short)|uniprotkb:Protein/nucleic acid deglycase DJ-1(gene name synonym)|uniprotkb:Maillard deglycase(gene name synonym)|uniprotkb:Parkinsonism-associated deglycase(gene name synonym)|uniprotkb:Protein DJ-1(gene name synonym)	psi-mi:"MI:0663"(confocal microscopy)	Ma et al. (2014)	imex:IM-23015|pubmed:24947010	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9685844|imex:IM-23015-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:1903076"(regulation of protein localization to plasma membrane)|go:"GO:1903208"(negative regulation of hydrogen peroxide-induced neuron death)|go:"GO:1990630"(IRE1-RACK1-PP2A complex)|go:"GO:2000114"(regulation of establishment of cell polarity)|go:"GO:2000543"(positive regulation of gastrulation)|go:"GO:2001244"(positive regulation of intrinsic apoptotic signaling pathway)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR036322|mint:P68040|reactome:R-MMU-5357905|reactome:R-MMU-5357956|reactome:R-MMU-5626978|go:"GO:0072344"(rescue of stalled ribosome)|ensembl:ENSMUSG00000020372(gene)|ensembl:ENSMUST00000020640(transcript)|go:"GO:0001891"(phagocytic cup)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007049"(cell cycle)|go:"GO:0007369"(gastrulation)|go:"GO:0008104"(protein localization)|go:"GO:0008200"(ion channel inhibitor activity)|go:"GO:0008656"(cysteine-type endopeptidase activator activity involved in apoptotic process)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0015935"(small ribosomal subunit)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019899"(enzyme binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0030292"(protein tyrosine kinase inhibitor activity)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030332"(cyclin binding)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030425"(dendrite)|go:"GO:0030496"(midbody)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0006412"(translation)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042998"(positive regulation of Golgi to plasma membrane protein transport)|go:"GO:0043005"(neuron projection)|go:"GO:0043022"(ribosome binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043204"(perikaryon)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0043473"(pigmentation)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0033137"(negative regulation of peptidyl-serine phosphorylation)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0044297"(cell body)|go:"GO:0045879"(negative regulation of smoothened signaling pathway)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048511"(rhythmic process)|go:"GO:0050765"(negative regulation of phagocytosis)|go:"GO:0051302"(regulation of cell division)|go:"GO:0051343"(positive regulation of cyclic-nucleotide phosphodiesterase activity)|go:"GO:0051434"(BH3 domain binding)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:0051901"(positive regulation of mitochondrial depolarization)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0071363"(cellular response to growth factor stimulus)|refseq:NP_032169.1	refseq:NP_065594.2|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1904782"(negative regulation of NMDA glutamate receptor activity)|go:"GO:1905259"(negative regulation of nitrosative stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1905516"(positive regulation of fertilization)|go:"GO:1990381"(ubiquitin-specific protease binding)|go:"GO:1990422"("glyoxalase (glycolic acid-forming) activity")|go:"GO:2000157"(negative regulation of ubiquitin-specific protease activity)|go:"GO:2000277"(positive regulation of oxidative phosphorylation uncoupler activity)|go:"GO:2000679"(positive regulation of transcription regulatory region DNA binding)|go:"GO:2000825"(positive regulation of androgen receptor activity)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|go:"GO:2001268"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|interpro:IPR002818(ThiJ/PfpI)|interpro:IPR006287(DJ-1)|interpro:IPR029062|mint:Q99LX0|reactome:R-MMU-3899300|reactome:R-MMU-9646399|ensembl:ENSMUSG00000028964(gene)|ensembl:ENSMUST00000030805(transcript)|ensembl:ENSMUST00000105673(transcript)|ensembl:ENSMUST00000105674(transcript)|ensembl:ENSMUST00000105675(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001963"(synaptic transmission, dopaminergic)|go:"GO:0002866"(positive regulation of acute inflammatory response to antigenic stimulus)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005507"(copper ion binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006281"(DNA repair)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006517"(protein deglycosylation)|go:"GO:0006914"(autophagy)|go:"GO:0006954"(inflammatory response)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007338"(single fertilization)|go:"GO:0008233"(peptidase activity)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0010273"(detoxification of copper ion)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016532"(superoxide dismutase copper chaperone activity)|go:"GO:0016570"(histone modification)|go:"GO:0016605"(PML body)|go:"GO:0016684"(oxidoreductase activity, acting on peroxide as acceptor)|go:"GO:0019249"(lactate biosynthetic process)|go:"GO:0019826"(oxygen sensor activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0019900"(kinase binding)|go:"GO:0019955"(cytokine binding)|go:"GO:0030073"(insulin secretion)|go:"GO:0030424"(axon)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032435"(negative regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0033182"(regulation of histone ubiquitination)|go:"GO:0033234"(negative regulation of protein sumoylation)|go:"GO:0033864"("positive regulation of NAD(P)H oxidase activity")|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035065"(regulation of histone acetylation)|go:"GO:0036470"(tyrosine 3-monooxygenase activator activity)|go:"GO:0036471"(cellular response to glyoxal)|go:"GO:0036478"(L-dopa decarboxylase activator activity)|go:"GO:0036524"(protein deglycase activity)|go:"GO:0036526"(peptidyl-cysteine deglycation)|go:"GO:0036527"(peptidyl-arginine deglycation)|go:"GO:0036528"(peptidyl-lysine deglycation)|go:"GO:0036529"(protein deglycation, glyoxal removal)|go:"GO:0036530"(protein deglycation, methylglyoxal removal)|go:"GO:0036531"(glutathione deglycation)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042743"(hydrogen peroxide metabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043005"(neuron projection)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043523"(regulation of neuron apoptotic process)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0044297"(cell body)|go:"GO:0044388"(small protein activating enzyme binding)|go:"GO:0044390"(ubiquitin-like protein conjugating enzyme binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045340"(mercury ion binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046295"(glycolate biosynthetic process)|go:"GO:0046826"(negative regulation of protein export from nucleus)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050681"(androgen receptor binding)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050787"(detoxification of mercury ion)|go:"GO:0050821"(protein stabilization)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051444"(negative regulation of ubiquitin-protein transferase activity)|go:"GO:0051583"(dopamine uptake involved in synaptic transmission)|go:"GO:0051881"(regulation of mitochondrial membrane potential)|go:"GO:0051899"(membrane depolarization)|go:"GO:0051920"(peroxiredoxin activity)|go:"GO:0060081"(membrane hyperpolarization)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0060765"(regulation of androgen receptor signaling pathway)|go:"GO:0061727"(methylglyoxal catabolic process to lactate)|go:"GO:0061827"(sperm head)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0070994"(detection of oxidative stress)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098793"(presynapse)|go:"GO:0106044"(guanine deglycation)|go:"GO:0106045"(guanine deglycation, methylglyoxal removal)|go:"GO:0106046"(guanine deglycation, glyoxal removal)|go:"GO:0110095"(cellular detoxification of aldehyde)|go:"GO:0140041"(cellular detoxification of methylglyoxal)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1901671"(positive regulation of superoxide dismutase activity)|go:"GO:1901984"(negative regulation of protein acetylation)|go:"GO:1902177"(positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1902236"(negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1902958"(positive regulation of mitochondrial electron transport, NADH to ubiquinone)|go:"GO:1903094"(negative regulation of protein K48-linked deubiquitination)|go:"GO:1903122"(negative regulation of TRAIL-activated apoptotic signaling pathway)|go:"GO:1903135"(cupric ion binding)|go:"GO:1903136"(cuprous ion binding)|go:"GO:1903168"(positive regulation of pyrroline-5-carboxylate reductase activity)|go:"GO:1903178"(positive regulation of tyrosine 3-monooxygenase activity)|go:"GO:1903181"(positive regulation of dopamine biosynthetic process)|go:"GO:1903189"(glyoxal metabolic process)|go:"GO:1903197"(positive regulation of L-dopa biosynthetic process)|go:"GO:1903200"(positive regulation of L-dopa decarboxylase activity)|go:"GO:1903202"(negative regulation of oxidative stress-induced cell death)|go:"GO:1903204"(negative regulation of oxidative stress-induced neuron death)|go:"GO:1903206"(negative regulation of hydrogen peroxide-induced cell death)|go:"GO:1903208"(negative regulation of hydrogen peroxide-induced neuron death)|go:"GO:1903377"(negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway)|go:"GO:1903384"(negative regulation of hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway)|go:"GO:1903427"(negative regulation of reactive oxygen species biosynthetic process)	go:"GO:0043025"(neuronal cell body)|go:"GO:0043005"(neuron projection)	-	-	figure legend:1E|dataset:Parkinsons - Interactions investigated in the context of Parkinsons disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-cerebral_cortical_neuron)|taxid:10090(Mouse cerebral cortical neuron)	-	2014/07/02	2014/10/16	rogid:LXHlhPtxUzHJNncoPteGw2iXsFg10090	rogid:dfkL4WeM+WgrYJa3aYTWbFyi0bk10090	intact-crc:6C8D99DB0F3FF3CB|rigid:eDYGTCCZX7CB6ve0CqeYOEkzyUE	false	-	-	-	-	psi-mi:"MI:1200"(immunocytochemistry)	psi-mi:"MI:1200"(immunocytochemistry)
uniprotkb:Q99LX0	uniprotkb:P68040	intact:EBI-1634273|uniprotkb:O88306|uniprotkb:Q3THB9|uniprotkb:Q3U509|ensembl:ENSMUSP00000030805|ensembl:ENSMUSP00000101298|ensembl:ENSMUSP00000101299|ensembl:ENSMUSP00000101300	intact:EBI-296749|ensembl:ENSMUSP00000020640|uniprotkb:P25388|uniprotkb:P99049|intact:EBI-1183965|uniprotkb:Q3THP0|uniprotkb:Q3THY7|uniprotkb:Q3TKQ0|uniprotkb:Q3TW88|uniprotkb:Q5NCC5|uniprotkb:Q5NCC6|uniprotkb:Q9CSQ0|uniprotkb:Q9ERM6	psi-mi:park7_mouse(display_long)|uniprotkb:Park7(gene name)|psi-mi:Park7(display_short)|uniprotkb:Protein/nucleic acid deglycase DJ-1(gene name synonym)|uniprotkb:Maillard deglycase(gene name synonym)|uniprotkb:Parkinsonism-associated deglycase(gene name synonym)|uniprotkb:Protein DJ-1(gene name synonym)	psi-mi:rack1_mouse(display_long)|uniprotkb:p205(gene name synonym)|uniprotkb:Receptor of activated protein kinase C 1(gene name synonym)|uniprotkb:12-3(gene name synonym)|uniprotkb:Gnb2-rs1(gene name synonym)|uniprotkb:Gnb2l1(gene name synonym)|uniprotkb:Guanine nucleotide-binding protein subunit beta-2-like 1(gene name synonym)|uniprotkb:Rack1(gene name)|psi-mi:Rack1(display_short)|uniprotkb:Receptor for activated C kinase(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Ma et al. (2014)	imex:IM-23015|pubmed:24947010	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9685831|imex:IM-23015-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_065594.2|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1904782"(negative regulation of NMDA glutamate receptor activity)|go:"GO:1905259"(negative regulation of nitrosative stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1905516"(positive regulation of fertilization)|go:"GO:1990381"(ubiquitin-specific protease binding)|go:"GO:1990422"("glyoxalase (glycolic acid-forming) activity")|go:"GO:2000157"(negative regulation of ubiquitin-specific protease activity)|go:"GO:2000277"(positive regulation of oxidative phosphorylation uncoupler activity)|go:"GO:2000679"(positive regulation of transcription regulatory region DNA binding)|go:"GO:2000825"(positive regulation of androgen receptor activity)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|go:"GO:2001268"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|interpro:IPR002818(ThiJ/PfpI)|interpro:IPR006287(DJ-1)|interpro:IPR029062|mint:Q99LX0|reactome:R-MMU-3899300|reactome:R-MMU-9646399|ensembl:ENSMUSG00000028964(gene)|ensembl:ENSMUST00000030805(transcript)|ensembl:ENSMUST00000105673(transcript)|ensembl:ENSMUST00000105674(transcript)|ensembl:ENSMUST00000105675(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001963"(synaptic transmission, dopaminergic)|go:"GO:0002866"(positive regulation of acute inflammatory response to antigenic stimulus)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005507"(copper ion binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006281"(DNA repair)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006517"(protein deglycosylation)|go:"GO:0006914"(autophagy)|go:"GO:0006954"(inflammatory response)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007338"(single fertilization)|go:"GO:0008233"(peptidase activity)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0010273"(detoxification of copper ion)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016532"(superoxide dismutase copper chaperone activity)|go:"GO:0016570"(histone modification)|go:"GO:0016605"(PML body)|go:"GO:0016684"(oxidoreductase activity, acting on peroxide as acceptor)|go:"GO:0019249"(lactate biosynthetic process)|go:"GO:0019826"(oxygen sensor activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0019900"(kinase binding)|go:"GO:0019955"(cytokine binding)|go:"GO:0030073"(insulin secretion)|go:"GO:0030424"(axon)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032435"(negative regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0033182"(regulation of histone ubiquitination)|go:"GO:0033234"(negative regulation of protein sumoylation)|go:"GO:0033864"("positive regulation of NAD(P)H oxidase activity")|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035065"(regulation of histone acetylation)|go:"GO:0036470"(tyrosine 3-monooxygenase activator activity)|go:"GO:0036471"(cellular response to glyoxal)|go:"GO:0036478"(L-dopa decarboxylase activator activity)|go:"GO:0036524"(protein deglycase activity)|go:"GO:0036526"(peptidyl-cysteine deglycation)|go:"GO:0036527"(peptidyl-arginine deglycation)|go:"GO:0036528"(peptidyl-lysine deglycation)|go:"GO:0036529"(protein deglycation, glyoxal removal)|go:"GO:0036530"(protein deglycation, methylglyoxal removal)|go:"GO:0036531"(glutathione deglycation)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042743"(hydrogen peroxide metabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043005"(neuron projection)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043523"(regulation of neuron apoptotic process)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0044297"(cell body)|go:"GO:0044388"(small protein activating enzyme binding)|go:"GO:0044390"(ubiquitin-like protein conjugating enzyme binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045340"(mercury ion binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046295"(glycolate biosynthetic process)|go:"GO:0046826"(negative regulation of protein export from nucleus)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050681"(androgen receptor binding)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050787"(detoxification of mercury ion)|go:"GO:0050821"(protein stabilization)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051444"(negative regulation of ubiquitin-protein transferase activity)|go:"GO:0051583"(dopamine uptake involved in synaptic transmission)|go:"GO:0051881"(regulation of mitochondrial membrane potential)|go:"GO:0051899"(membrane depolarization)|go:"GO:0051920"(peroxiredoxin activity)|go:"GO:0060081"(membrane hyperpolarization)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0060765"(regulation of androgen receptor signaling pathway)|go:"GO:0061727"(methylglyoxal catabolic process to lactate)|go:"GO:0061827"(sperm head)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0070994"(detection of oxidative stress)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098793"(presynapse)|go:"GO:0106044"(guanine deglycation)|go:"GO:0106045"(guanine deglycation, methylglyoxal removal)|go:"GO:0106046"(guanine deglycation, glyoxal removal)|go:"GO:0110095"(cellular detoxification of aldehyde)|go:"GO:0140041"(cellular detoxification of methylglyoxal)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1901671"(positive regulation of superoxide dismutase activity)|go:"GO:1901984"(negative regulation of protein acetylation)|go:"GO:1902177"(positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1902236"(negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1902958"(positive regulation of mitochondrial electron transport, NADH to ubiquinone)|go:"GO:1903094"(negative regulation of protein K48-linked deubiquitination)|go:"GO:1903122"(negative regulation of TRAIL-activated apoptotic signaling pathway)|go:"GO:1903135"(cupric ion binding)|go:"GO:1903136"(cuprous ion binding)|go:"GO:1903168"(positive regulation of pyrroline-5-carboxylate reductase activity)|go:"GO:1903178"(positive regulation of tyrosine 3-monooxygenase activity)|go:"GO:1903181"(positive regulation of dopamine biosynthetic process)|go:"GO:1903189"(glyoxal metabolic process)|go:"GO:1903197"(positive regulation of L-dopa biosynthetic process)|go:"GO:1903200"(positive regulation of L-dopa decarboxylase activity)|go:"GO:1903202"(negative regulation of oxidative stress-induced cell death)|go:"GO:1903204"(negative regulation of oxidative stress-induced neuron death)|go:"GO:1903206"(negative regulation of hydrogen peroxide-induced cell death)|go:"GO:1903208"(negative regulation of hydrogen peroxide-induced neuron death)|go:"GO:1903377"(negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway)|go:"GO:1903384"(negative regulation of hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway)|go:"GO:1903427"(negative regulation of reactive oxygen species biosynthetic process)	go:"GO:1903076"(regulation of protein localization to plasma membrane)|go:"GO:1903208"(negative regulation of hydrogen peroxide-induced neuron death)|go:"GO:1990630"(IRE1-RACK1-PP2A complex)|go:"GO:2000114"(regulation of establishment of cell polarity)|go:"GO:2000543"(positive regulation of gastrulation)|go:"GO:2001244"(positive regulation of intrinsic apoptotic signaling pathway)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR036322|mint:P68040|reactome:R-MMU-5357905|reactome:R-MMU-5357956|reactome:R-MMU-5626978|go:"GO:0072344"(rescue of stalled ribosome)|ensembl:ENSMUSG00000020372(gene)|ensembl:ENSMUST00000020640(transcript)|go:"GO:0001891"(phagocytic cup)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007049"(cell cycle)|go:"GO:0007369"(gastrulation)|go:"GO:0008104"(protein localization)|go:"GO:0008200"(ion channel inhibitor activity)|go:"GO:0008656"(cysteine-type endopeptidase activator activity involved in apoptotic process)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0015935"(small ribosomal subunit)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019899"(enzyme binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0030292"(protein tyrosine kinase inhibitor activity)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030332"(cyclin binding)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030425"(dendrite)|go:"GO:0030496"(midbody)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0006412"(translation)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042998"(positive regulation of Golgi to plasma membrane protein transport)|go:"GO:0043005"(neuron projection)|go:"GO:0043022"(ribosome binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043204"(perikaryon)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0043473"(pigmentation)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0033137"(negative regulation of peptidyl-serine phosphorylation)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0044297"(cell body)|go:"GO:0045879"(negative regulation of smoothened signaling pathway)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048511"(rhythmic process)|go:"GO:0050765"(negative regulation of phagocytosis)|go:"GO:0051302"(regulation of cell division)|go:"GO:0051343"(positive regulation of cyclic-nucleotide phosphodiesterase activity)|go:"GO:0051434"(BH3 domain binding)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:0051901"(positive regulation of mitochondrial depolarization)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0071363"(cellular response to growth factor stimulus)|refseq:NP_032169.1	-	-	-	figure legend:1D and  4|antagonist:"CHEBI:16240 hydrogen peroxide (causes formation of reactive oxygen species)"|antagonist:"CHEBI:641 MPP+ (1-methyl-4-phenylpyridinium) (causes formation of reactive oxygen species)"|dataset:Parkinsons - Interactions investigated in the context of Parkinsons disease|dataset:Neurodegeneration - Publications depicting interactions involved in neurodegenerative diseases.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-cerebral_cortical_neuron)|taxid:10090(Mouse cerebral cortical neuron)	-	2014/07/02	2014/10/16	rogid:dfkL4WeM+WgrYJa3aYTWbFyi0bk10090	rogid:LXHlhPtxUzHJNncoPteGw2iXsFg10090	intact-crc:0CE1755CA9F87EC1|rigid:eDYGTCCZX7CB6ve0CqeYOEkzyUE	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)