#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q97ZL0	uniprotkb:Q97ZL0	intact:EBI-9539752|ensemblbacteria:AAK41170	intact:EBI-9539752|ensemblbacteria:AAK41170	psi-mi:acyp_sacs2(display_long)|uniprotkb:SSO0887(locus name)|uniprotkb:acyP(gene name)|psi-mi:acyP(display_short)|uniprotkb:Acylphosphate phosphohydrolase(gene name synonym)	psi-mi:acyp_sacs2(display_long)|uniprotkb:SSO0887(locus name)|uniprotkb:acyP(gene name)|psi-mi:acyP(display_short)|uniprotkb:Acylphosphate phosphohydrolase(gene name synonym)	psi-mi:"MI:0051"(fluorescence technology)	de et al. (2014)	imex:IM-22916|pubmed:24893801	taxid:273057(sulso)|taxid:273057("Sulfolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)")	taxid:273057(sulso)|taxid:273057("Sulfolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-9539750|imex:IM-22916-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rcsb pdb:4OJ3|rcsb pdb:4OJG|rcsb pdb:4OJH|interpro:IPR001792(Acylphosphatase)|interpro:IPR017968|rcsb pdb:1Y9O|rcsb pdb:2BJD|rcsb pdb:2BJE|rcsb pdb:4OIX|rcsb pdb:4OJ1|interpro:IPR036046|interpro:IPR020456|ensemblbacteria:AAK41170(transcript)|ensemblbacteria:SSO0887(gene)|go:"GO:0003998"(acylphosphatase activity)	rcsb pdb:4OJ3|rcsb pdb:4OJG|rcsb pdb:4OJH|interpro:IPR001792(Acylphosphatase)|interpro:IPR017968|rcsb pdb:1Y9O|rcsb pdb:2BJD|rcsb pdb:2BJE|rcsb pdb:4OIX|rcsb pdb:4OJ1|interpro:IPR036046|interpro:IPR020456|ensemblbacteria:AAK41170(transcript)|ensemblbacteria:SSO0887(gene)|go:"GO:0003998"(acylphosphatase activity)	-	-	-	figure legend:f4|comment:"In order to verify whether the same model holds for the three B4 mutants here investigated, we  monitored the aggregation time courses of the full length V84P, V84D and Y86E Sso AcP in the  presence of increasing concentrations of the N11 peptide, ranging from 0 to a 20-fold molar excess,  and using Thioflavin-T fluorescence as the aggregation probe (Figure 4). The results revealed that no  significant differences in the aggregation behaviour of the three mutants could be observed as the  amount of N11 was increased. While a 10-fold molar excess of N11 decreases the aggregation rate  of wt Sso AcP by 80% (Figure 4B; reprinted from [33]), in the case of the three mutants the observed  aggregation rates were within 10% of the value obtained in the absence of the peptide (Figure 4D,  4F, 4H). These results show that aggregation of the V84D, V84P and Y86E Sso AcP variants is nottriggered by the intermolecular interaction between the N-terminal segment and B4, as instead  previously shown for wt Sso AcP."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/05/23	2014/10/16	rogid:qx8N41WvT6wlPthaJ3qWGjxHYu0273057	rogid:qx8N41WvT6wlPthaJ3qWGjxHYu0273057	intact-crc:D848607494CABF94|rigid:fePi8YfPeQRFUdaVbu1qsl/sGe8	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)