#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P00974	uniprotkb:P29990	intact:EBI-1032263	intact:EBI-9520311	psi-mi:bpt1_bovin(display_long)|uniprotkb:Basic protease inhibitor(gene name synonym)|uniprotkb:Aprotinin(gene name synonym)	psi-mi:polg_den26(display_long)	psi-mi:"MI:0077"(nuclear magnetic resonance)	Chen et al. (2014)	pubmed:24859037|imex:IM-22624	taxid:9913(bovin)|taxid:9913("Bos taurus (Bovine)")	taxid:31634(den26)|taxid:31634("Dengue virus type 2 (strain Thailand/16681/1984)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-9520307|imex:IM-22624-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0002020"(protease binding)|go:"GO:0004867"(serine-type endopeptidase inhibitor activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005615"(extracellular space)|go:"GO:0019870"(potassium channel inhibitor activity)|go:"GO:0032023"(trypsinogen activation)|go:"GO:0035375"(zymogen binding)|go:"GO:0043199"(sulfate binding)|go:"GO:0070495"(negative regulation of thrombin-activated receptor signaling pathway)|go:"GO:0090331"(negative regulation of platelet aggregation)|go:"GO:0097180"(serine protease inhibitor complex)|go:"GO:1900004"(negative regulation of serine-type endopeptidase activity)|interpro:IPR002223(Proteinase inhibitor I2, Kunitz metazoa)|interpro:IPR020901|interpro:IPR036880|rcsb pdb:1D0D|rcsb pdb:1EAW|rcsb pdb:1EJM|rcsb pdb:1F5R|rcsb pdb:1AAL|rcsb pdb:1F7Z|rcsb pdb:1FAK|rcsb pdb:1FAN|rcsb pdb:1FY8|rcsb pdb:1G6X|rcsb pdb:1JV8|rcsb pdb:1JV9|rcsb pdb:1K09|rcsb pdb:1B0C|rcsb pdb:1K6U|rcsb pdb:1LD5|rcsb pdb:1BHC|rcsb pdb:1BPI|rcsb pdb:1LD6|rcsb pdb:1MTN|rcsb pdb:1BPT|rcsb pdb:1BRB|rcsb pdb:1NAG|rcsb pdb:1BTH|rcsb pdb:1BTI|rcsb pdb:1OA5|rcsb pdb:1OA6|rcsb pdb:1P2I|rcsb pdb:1P2J|rcsb pdb:1P2K|rcsb pdb:1P2M|rcsb pdb:1P2N|rcsb pdb:1P2O|rcsb pdb:1P2Q|rcsb pdb:1PIT|rcsb pdb:1BZ5|rcsb pdb:1QLQ|rcsb pdb:1T7C|rcsb pdb:1T8L|rcsb pdb:1T8M|rcsb pdb:1T8N|rcsb pdb:1T8O|rcsb pdb:1TPA|rcsb pdb:1BZX|rcsb pdb:1UUA|rcsb pdb:1UUB|rcsb pdb:1YKT|rcsb pdb:1YLC|rcsb pdb:1CBW|rcsb pdb:1YLD|rcsb pdb:2FI3|rcsb pdb:2FI4|rcsb pdb:2FI5|rcsb pdb:2FTL|rcsb pdb:1CO7|rcsb pdb:2FTM|rcsb pdb:2HEX|rcsb pdb:2IJO|rcsb pdb:2KAI|rcsb pdb:2PTC|rcsb pdb:2R9P|rcsb pdb:2RA3|rcsb pdb:2TGP|rcsb pdb:2TPI|rcsb pdb:2ZJX|rcsb pdb:2ZVX|rcsb pdb:3BTD|rcsb pdb:3BTE|rcsb pdb:3BTF|rcsb pdb:3BTG|rcsb pdb:3BTH|rcsb pdb:3BTK|rcsb pdb:3BTM|rcsb pdb:3BTQ|rcsb pdb:3BTT|rcsb pdb:3BTW|rcsb pdb:3FP6|rcsb pdb:3FP7|rcsb pdb:3FP8|rcsb pdb:3GYM|rcsb pdb:3LDI|rcsb pdb:3LDJ|rcsb pdb:3LDM|rcsb pdb:3OTJ|rcsb pdb:3P92|rcsb pdb:3P95|rcsb pdb:3TGI|rcsb pdb:3TGJ|rcsb pdb:3TGK|rcsb pdb:3TPI|rcsb pdb:3U1J|rcsb pdb:3WNY|rcsb pdb:4BNR|rcsb pdb:4DG4|rcsb pdb:4PTI|rcsb pdb:4TPI|rcsb pdb:4WWY|rcsb pdb:4WXV|rcsb pdb:4Y0Y|rcsb pdb:4Y0Z|rcsb pdb:4Y10|rcsb pdb:4Y11|rcsb pdb:5JB4|rcsb pdb:5JB5|rcsb pdb:5JB6|rcsb pdb:5JB7|rcsb pdb:5PTI|rcsb pdb:5XX2|rcsb pdb:5XX3|rcsb pdb:5XX4|rcsb pdb:5XX5|rcsb pdb:5XX6|rcsb pdb:5XX7|rcsb pdb:5XX8|rcsb pdb:5YVU|rcsb pdb:5YW1|rcsb pdb:6F1F|rcsb pdb:6PTI|rcsb pdb:7PTI|rcsb pdb:8PTI|rcsb pdb:9PTI|mint:P00974|dip:DIP-6113N	mint:P29990|interpro:IPR011492(DEAD box, Flavivirus)|interpro:IPR000069(Flavivirus envelope glycoprotein M)|interpro:IPR001122(Flavivirus capsid protein C)|interpro:IPR026470|interpro:IPR001157(Flavivirus non-structural protein NS1)|interpro:IPR000752(Flavivirus non-structural protein NS2A)|interpro:IPR000487(Flavivirus non-structural protein NS2B)|interpro:IPR000404(Flavivirus non-structural protein NS4A)|interpro:IPR001528(Flavivirus non-structural protein NS4B)|interpro:IPR002535(Flavivirus polyprotein propeptide)|interpro:IPR000336(Flaviviral glycoprotein E, immunoglobulin-like)|interpro:IPR001850("Peptidase S7, flavivirus helicase (NS3)")|interpro:IPR027287|interpro:IPR014412(Genome polyprotein, Flavivirus type)|interpro:IPR011998(Viral glycoprotein E, central and dimerisation)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR026490|interpro:IPR027417|interpro:IPR000208(RNA-directed RNA polymerase, flaviviral)|interpro:IPR007094(RNA-directed RNA polymerase, positive-strand RNA eukaryotic virus)|interpro:IPR002877(Ribosomal RNA methyltransferase RrmJ/FtsJ)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR036253|interpro:IPR037172|interpro:IPR029063|interpro:IPR038688|interpro:IPR013755(Flaviviral glycoprotein E, central domain, region 1)|interpro:IPR013756(Flaviviral glycoprotein E, central domain, region 2)|interpro:IPR038055|interpro:IPR038302|interpro:IPR038345|interpro:IPR043502|interpro:IPR043504|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0004482"("mRNA (guanine-N7-)-methyltransferase activity")|go:"GO:0004483"("mRNA (nucleoside-2'-O-)-methyltransferase activity")|go:"GO:0005198"(structural molecule activity)|go:"GO:0005216"(ion channel activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019028"(viral capsid)|go:"GO:0019031"(viral envelope)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0033650"(host cell mitochondrion)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039520"(induction by virus of host autophagy)|go:"GO:0039545"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of MAVS activity)|go:"GO:0039564"(suppression by virus of host JAK-STAT cascade via inhibition of STAT2 activity)|go:"GO:0039574"(suppression by virus of host JAK-STAT cascade via inhibition of host TYK2 activity)|go:"GO:0039653"(suppression by virus of host transcription)|go:"GO:0039654"(fusion of virus membrane with host endosome membrane)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0039707"(pore formation by virus in membrane of host cell)|go:"GO:0042025"(host cell nucleus)|go:"GO:0044167"(host cell endoplasmic reticulum membrane)|go:"GO:0044220"(host cell perinuclear region of cytoplasm)|go:"GO:0044385"(integral to membrane of host cell)|go:"GO:0046872"(metal ion binding)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0055036"(virion membrane)|go:"GO:0075512"(clathrin-dependent endocytosis of virus by host cell)|go:"GO:0140272"(exogenous protein binding)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|rcsb pdb:2R69|rcsb pdb:4O6B|go:"GO:0051259"(protein complex oligomerization)	-	-	-	figure legend:f2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/05/08	2014/10/16	rogid:yNcGpj9WW2ZQ83vl7hiQqhKZLdQ9913	rogid:wLl/KBYYN7tYPHn0Iikbs2L7MZM31634	intact-crc:F6819DF5F878BA86|rigid:lylxY6gF+FKah3Ej+d1lfxAdbyg	false	-	polyprotein fragment:1476-2093	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P00974	uniprotkb:P29990	intact:EBI-1032263	intact:EBI-9520311	psi-mi:bpt1_bovin(display_long)|uniprotkb:Basic protease inhibitor(gene name synonym)|uniprotkb:Aprotinin(gene name synonym)	psi-mi:polg_den26(display_long)	psi-mi:"MI:0077"(nuclear magnetic resonance)	Chen et al. (2014)	pubmed:24859037|imex:IM-22624	taxid:9913(bovin)|taxid:9913("Bos taurus (Bovine)")	taxid:31634(den26)|taxid:31634("Dengue virus type 2 (strain Thailand/16681/1984)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-9520307|imex:IM-22624-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0002020"(protease binding)|go:"GO:0004867"(serine-type endopeptidase inhibitor activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005615"(extracellular space)|go:"GO:0019870"(potassium channel inhibitor activity)|go:"GO:0032023"(trypsinogen activation)|go:"GO:0035375"(zymogen binding)|go:"GO:0043199"(sulfate binding)|go:"GO:0070495"(negative regulation of thrombin-activated receptor signaling pathway)|go:"GO:0090331"(negative regulation of platelet aggregation)|go:"GO:0097180"(serine protease inhibitor complex)|go:"GO:1900004"(negative regulation of serine-type endopeptidase activity)|interpro:IPR002223(Proteinase inhibitor I2, Kunitz metazoa)|interpro:IPR020901|interpro:IPR036880|rcsb pdb:1D0D|rcsb pdb:1EAW|rcsb pdb:1EJM|rcsb pdb:1F5R|rcsb pdb:1AAL|rcsb pdb:1F7Z|rcsb pdb:1FAK|rcsb pdb:1FAN|rcsb pdb:1FY8|rcsb pdb:1G6X|rcsb pdb:1JV8|rcsb pdb:1JV9|rcsb pdb:1K09|rcsb pdb:1B0C|rcsb pdb:1K6U|rcsb pdb:1LD5|rcsb pdb:1BHC|rcsb pdb:1BPI|rcsb pdb:1LD6|rcsb pdb:1MTN|rcsb pdb:1BPT|rcsb pdb:1BRB|rcsb pdb:1NAG|rcsb pdb:1BTH|rcsb pdb:1BTI|rcsb pdb:1OA5|rcsb pdb:1OA6|rcsb pdb:1P2I|rcsb pdb:1P2J|rcsb pdb:1P2K|rcsb pdb:1P2M|rcsb pdb:1P2N|rcsb pdb:1P2O|rcsb pdb:1P2Q|rcsb pdb:1PIT|rcsb pdb:1BZ5|rcsb pdb:1QLQ|rcsb pdb:1T7C|rcsb pdb:1T8L|rcsb pdb:1T8M|rcsb pdb:1T8N|rcsb pdb:1T8O|rcsb pdb:1TPA|rcsb pdb:1BZX|rcsb pdb:1UUA|rcsb pdb:1UUB|rcsb pdb:1YKT|rcsb pdb:1YLC|rcsb pdb:1CBW|rcsb pdb:1YLD|rcsb pdb:2FI3|rcsb pdb:2FI4|rcsb pdb:2FI5|rcsb pdb:2FTL|rcsb pdb:1CO7|rcsb pdb:2FTM|rcsb pdb:2HEX|rcsb pdb:2IJO|rcsb pdb:2KAI|rcsb pdb:2PTC|rcsb pdb:2R9P|rcsb pdb:2RA3|rcsb pdb:2TGP|rcsb pdb:2TPI|rcsb pdb:2ZJX|rcsb pdb:2ZVX|rcsb pdb:3BTD|rcsb pdb:3BTE|rcsb pdb:3BTF|rcsb pdb:3BTG|rcsb pdb:3BTH|rcsb pdb:3BTK|rcsb pdb:3BTM|rcsb pdb:3BTQ|rcsb pdb:3BTT|rcsb pdb:3BTW|rcsb pdb:3FP6|rcsb pdb:3FP7|rcsb pdb:3FP8|rcsb pdb:3GYM|rcsb pdb:3LDI|rcsb pdb:3LDJ|rcsb pdb:3LDM|rcsb pdb:3OTJ|rcsb pdb:3P92|rcsb pdb:3P95|rcsb pdb:3TGI|rcsb pdb:3TGJ|rcsb pdb:3TGK|rcsb pdb:3TPI|rcsb pdb:3U1J|rcsb pdb:3WNY|rcsb pdb:4BNR|rcsb pdb:4DG4|rcsb pdb:4PTI|rcsb pdb:4TPI|rcsb pdb:4WWY|rcsb pdb:4WXV|rcsb pdb:4Y0Y|rcsb pdb:4Y0Z|rcsb pdb:4Y10|rcsb pdb:4Y11|rcsb pdb:5JB4|rcsb pdb:5JB5|rcsb pdb:5JB6|rcsb pdb:5JB7|rcsb pdb:5PTI|rcsb pdb:5XX2|rcsb pdb:5XX3|rcsb pdb:5XX4|rcsb pdb:5XX5|rcsb pdb:5XX6|rcsb pdb:5XX7|rcsb pdb:5XX8|rcsb pdb:5YVU|rcsb pdb:5YW1|rcsb pdb:6F1F|rcsb pdb:6PTI|rcsb pdb:7PTI|rcsb pdb:8PTI|rcsb pdb:9PTI|mint:P00974|dip:DIP-6113N	mint:P29990|interpro:IPR011492(DEAD box, Flavivirus)|interpro:IPR000069(Flavivirus envelope glycoprotein M)|interpro:IPR001122(Flavivirus capsid protein C)|interpro:IPR026470|interpro:IPR001157(Flavivirus non-structural protein NS1)|interpro:IPR000752(Flavivirus non-structural protein NS2A)|interpro:IPR000487(Flavivirus non-structural protein NS2B)|interpro:IPR000404(Flavivirus non-structural protein NS4A)|interpro:IPR001528(Flavivirus non-structural protein NS4B)|interpro:IPR002535(Flavivirus polyprotein propeptide)|interpro:IPR000336(Flaviviral glycoprotein E, immunoglobulin-like)|interpro:IPR001850("Peptidase S7, flavivirus helicase (NS3)")|interpro:IPR027287|interpro:IPR014412(Genome polyprotein, Flavivirus type)|interpro:IPR011998(Viral glycoprotein E, central and dimerisation)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR026490|interpro:IPR027417|interpro:IPR000208(RNA-directed RNA polymerase, flaviviral)|interpro:IPR007094(RNA-directed RNA polymerase, positive-strand RNA eukaryotic virus)|interpro:IPR002877(Ribosomal RNA methyltransferase RrmJ/FtsJ)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR036253|interpro:IPR037172|interpro:IPR029063|interpro:IPR038688|interpro:IPR013755(Flaviviral glycoprotein E, central domain, region 1)|interpro:IPR013756(Flaviviral glycoprotein E, central domain, region 2)|interpro:IPR038055|interpro:IPR038302|interpro:IPR038345|interpro:IPR043502|interpro:IPR043504|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0003968"(RNA-directed 5'-3' RNA polymerase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0004482"("mRNA (guanine-N7-)-methyltransferase activity")|go:"GO:0004483"("mRNA (nucleoside-2'-O-)-methyltransferase activity")|go:"GO:0005198"(structural molecule activity)|go:"GO:0005216"(ion channel activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019028"(viral capsid)|go:"GO:0019031"(viral envelope)|go:"GO:0019062"(virion attachment to host cell)|go:"GO:0033650"(host cell mitochondrion)|go:"GO:0039502"(suppression by virus of host type I interferon-mediated signaling pathway)|go:"GO:0039520"(induction by virus of host autophagy)|go:"GO:0039545"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of MAVS activity)|go:"GO:0039564"(suppression by virus of host JAK-STAT cascade via inhibition of STAT2 activity)|go:"GO:0039574"(suppression by virus of host JAK-STAT cascade via inhibition of host TYK2 activity)|go:"GO:0039653"(suppression by virus of host transcription)|go:"GO:0039654"(fusion of virus membrane with host endosome membrane)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0039707"(pore formation by virus in membrane of host cell)|go:"GO:0042025"(host cell nucleus)|go:"GO:0044167"(host cell endoplasmic reticulum membrane)|go:"GO:0044220"(host cell perinuclear region of cytoplasm)|go:"GO:0044385"(integral to membrane of host cell)|go:"GO:0046872"(metal ion binding)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0055036"(virion membrane)|go:"GO:0075512"(clathrin-dependent endocytosis of virus by host cell)|go:"GO:0140272"(exogenous protein binding)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|rcsb pdb:2R69|rcsb pdb:4O6B|go:"GO:0051259"(protein complex oligomerization)	-	-	-	figure legend:f2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/05/08	2014/10/16	rogid:yNcGpj9WW2ZQ83vl7hiQqhKZLdQ9913	rogid:wLl/KBYYN7tYPHn0Iikbs2L7MZM31634	intact-crc:F6819DF5F878BA86|rigid:lylxY6gF+FKah3Ej+d1lfxAdbyg	false	-	polyprotein fragment:1346-1475	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)