#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P20807	uniprotkb:P20807	intact:EBI-5655000|ensembl:ENSP00000380349|uniprotkb:Q9Y5S6|uniprotkb:Q9Y5S7|uniprotkb:Q9BTU4|uniprotkb:A6H8K6|uniprotkb:Q7L4R0|uniprotkb:Q9BQC8	intact:EBI-5655000|ensembl:ENSP00000380349|uniprotkb:Q9Y5S6|uniprotkb:Q9Y5S7|uniprotkb:Q9BTU4|uniprotkb:A6H8K6|uniprotkb:Q7L4R0|uniprotkb:Q9BQC8	psi-mi:can3_human(display_long)|uniprotkb:CANP3(gene name synonym)|uniprotkb:CANPL3(gene name synonym)|uniprotkb:Calcium-activated neutral proteinase 3(gene name synonym)|uniprotkb:Calpain L3(gene name synonym)|uniprotkb:Calpain p94(gene name synonym)|uniprotkb:Muscle-specific calcium-activated neutral protease 3(gene name synonym)|uniprotkb:NCL1(gene name synonym)|uniprotkb:New calpain 1(gene name synonym)|uniprotkb:CAPN3(gene name)|psi-mi:CAPN3(display_short)	psi-mi:can3_human(display_long)|uniprotkb:CANP3(gene name synonym)|uniprotkb:CANPL3(gene name synonym)|uniprotkb:Calcium-activated neutral proteinase 3(gene name synonym)|uniprotkb:Calpain L3(gene name synonym)|uniprotkb:Calpain p94(gene name synonym)|uniprotkb:Muscle-specific calcium-activated neutral protease 3(gene name synonym)|uniprotkb:NCL1(gene name synonym)|uniprotkb:New calpain 1(gene name synonym)|uniprotkb:CAPN3(gene name)|psi-mi:CAPN3(display_short)	psi-mi:"MI:0114"(x-ray crystallography)	Partha et al. (2014)	pubmed:24846670|imex:IM-22605	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-9525089|imex:IM-22605-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000092529(gene)|ensembl:ENST00000397163(transcript)|go:"GO:0003824"(catalytic activity)|go:"GO:0004198"(calcium-dependent cysteine-type endopeptidase activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005622"(intracellular anatomical structure)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006508"(proteolysis)|go:"GO:0006915"(apoptotic process)|go:"GO:0007517"(muscle organ development)|go:"GO:0008233"(peptidase activity)|go:"GO:0008234"(cysteine-type peptidase activity)|go:"GO:0008307"(structural constituent of muscle)|go:"GO:0014718"(positive regulation of satellite cell activation involved in skeletal muscle regeneration)|go:"GO:0014850"(response to muscle activity)|go:"GO:0030016"(myofibril)|go:"GO:0030018"(Z disc)|go:"GO:0030163"(protein catabolic process)|go:"GO:0030239"(myofibril assembly)|refseq:NP_000061.1|refseq:NP_077320.1|refseq:NP_775110.1|refseq:NP_775111.1|refseq:NP_775112.1|refseq:NP_775113.1|go:"GO:0030315"(T-tubule)|go:"GO:0031402"(sodium ion binding)|go:"GO:0031432"(titin binding)|go:"GO:0031648"(protein destabilization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033234"(negative regulation of protein sumoylation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045214"(sarcomere organization)|go:"GO:0045661"(regulation of myoblast differentiation)|go:"GO:0045862"(positive regulation of proteolysis)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046716"(muscle cell cellular homeostasis)|go:"GO:0050790"(regulation of catalytic activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051281"(positive regulation of release of sequestered calcium ion into cytosol)|go:"GO:0051592"(response to calcium ion)|go:"GO:0055103"(ligase regulator activity)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0061061"(muscle structure development)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070315"(G1 to G0 transition involved in cell differentiation)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0071472"(cellular response to salt stress)|go:"GO:0072657"(protein localization to membrane)|go:"GO:0097264"(self proteolysis)|go:"GO:1990092"(calcium-dependent self proteolysis)|interpro:IPR000169(Peptidase, cysteine peptidase active site)|interpro:IPR001300(Peptidase C2, calpain)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|interpro:IPR022682|interpro:IPR022683|interpro:IPR022684|interpro:IPR029531|interpro:IPR033883|interpro:IPR036213|interpro:IPR038765|mint:P20807|rcsb pdb:1Y9V|rcsb pdb:4OKH|rcsb pdb:6BDT|rcsb pdb:6BGP|rcsb pdb:6BJD|rcsb pdb:6BKJ|reactome:R-HSA-1474228	ensembl:ENSG00000092529(gene)|ensembl:ENST00000397163(transcript)|go:"GO:0003824"(catalytic activity)|go:"GO:0004198"(calcium-dependent cysteine-type endopeptidase activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005622"(intracellular anatomical structure)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006508"(proteolysis)|go:"GO:0006915"(apoptotic process)|go:"GO:0007517"(muscle organ development)|go:"GO:0008233"(peptidase activity)|go:"GO:0008234"(cysteine-type peptidase activity)|go:"GO:0008307"(structural constituent of muscle)|go:"GO:0014718"(positive regulation of satellite cell activation involved in skeletal muscle regeneration)|go:"GO:0014850"(response to muscle activity)|go:"GO:0030016"(myofibril)|go:"GO:0030018"(Z disc)|go:"GO:0030163"(protein catabolic process)|go:"GO:0030239"(myofibril assembly)|refseq:NP_000061.1|refseq:NP_077320.1|refseq:NP_775110.1|refseq:NP_775111.1|refseq:NP_775112.1|refseq:NP_775113.1|go:"GO:0030315"(T-tubule)|go:"GO:0031402"(sodium ion binding)|go:"GO:0031432"(titin binding)|go:"GO:0031648"(protein destabilization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033234"(negative regulation of protein sumoylation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045214"(sarcomere organization)|go:"GO:0045661"(regulation of myoblast differentiation)|go:"GO:0045862"(positive regulation of proteolysis)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046716"(muscle cell cellular homeostasis)|go:"GO:0050790"(regulation of catalytic activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051281"(positive regulation of release of sequestered calcium ion into cytosol)|go:"GO:0051592"(response to calcium ion)|go:"GO:0055103"(ligase regulator activity)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0061061"(muscle structure development)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070315"(G1 to G0 transition involved in cell differentiation)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0071472"(cellular response to salt stress)|go:"GO:0072657"(protein localization to membrane)|go:"GO:0097264"(self proteolysis)|go:"GO:1990092"(calcium-dependent self proteolysis)|interpro:IPR000169(Peptidase, cysteine peptidase active site)|interpro:IPR001300(Peptidase C2, calpain)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|interpro:IPR022682|interpro:IPR022683|interpro:IPR022684|interpro:IPR029531|interpro:IPR033883|interpro:IPR036213|interpro:IPR038765|mint:P20807|rcsb pdb:1Y9V|rcsb pdb:4OKH|rcsb pdb:6BDT|rcsb pdb:6BGP|rcsb pdb:6BJD|rcsb pdb:6BKJ|reactome:R-HSA-1474228	rcsb pdb:4OKH	-	-	figure legend:f2 f3 f4 f5 t1|comment:"The resulting electron density map showed three calpain-3  PEF domain chains in the asymmetric unit. Chains A and B form one homodimer unit (Figure  2A), while chain C dimerizes with a symmetry-related molecule via a crystallographic 2-fold  axis."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/05/14	2014/10/16	rogid:niIxeCH+wcEYovZ1/3/zTO27bOU9606	rogid:niIxeCH+wcEYovZ1/3/zTO27bOU9606	intact-crc:B7C2A749288B0A73|rigid:hayZ3ywszYmIBmU1l+ixaMvAdlw	false	binding-associated region:650-821	binding-associated region:650-821	2	0	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)