#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q9EQU3	uniprotkb:Q62703	intact:EBI-9979528|ensembl:ENSMUSP00000082207|uniprotkb:F8VPN5|uniprotkb:Q4L0K3|uniprotkb:Q4L0K4|uniprotkb:Q99MF2|uniprotkb:Q99MQ8	intact:EBI-9979590|uniprotkb:Q6P6X5|ensembl:ENSRNOP00000021817	psi-mi:tlr9_mouse(display_long)|uniprotkb:Tlr9(gene name)|psi-mi:Tlr9(display_short)	psi-mi:rcn2_rat(display_long)|uniprotkb:Rcn2(gene name)|psi-mi:Rcn2(display_short)|uniprotkb:Erc55(gene name synonym)|uniprotkb:Calcium-binding protein ERC-55(gene name synonym)|uniprotkb:Taipoxin-associated calcium-binding protein 49(gene name synonym)	psi-mi:"MI:0676"(tandem affinity purification)	Shintani et al. (2014)	imex:IM-23524|pubmed:24610369	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-9979662|imex:IM-23524-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000045322(gene)|ensembl:ENSMUST00000062241(transcript)|go:"GO:0001774"(microglial cell activation)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0002224"(toll-like receptor signaling pathway)|go:"GO:0002237"(response to molecule of bacterial origin)|go:"GO:0002639"(positive regulation of immunoglobulin production)|go:"GO:0002730"(regulation of dendritic cell cytokine production)|go:"GO:0002755"(MyD88-dependent toll-like receptor signaling pathway)|go:"GO:0005149"(interleukin-1 receptor binding)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|refseq:NP_112455.2|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0045087"(innate immune response)|go:"GO:0045322"(unmethylated CpG binding)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0045577"(regulation of B cell differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0050864"(regulation of B cell activation)|go:"GO:0050871"(positive regulation of B cell activation)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051607"(defense response to virus)|go:"GO:0051770"(positive regulation of nitric-oxide synthase biosynthetic process)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071248"(cellular response to metal ion)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:0005886"(plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0007252"(I-kappaB phosphorylation)|go:"GO:0008584"(male gonad development)|go:"GO:0009615"(response to virus)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030277"(maintenance of gastrointestinal epithelium)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0032009"(early phagosome)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032717"(negative regulation of interleukin-8 production)|go:"GO:0005789"(endoplasmic reticulum membrane)|rcsb pdb:4QDH|rcsb pdb:5ZLN|reactome:R-MMU-109704|reactome:R-MMU-1679131|reactome:R-MMU-168138|go:"GO:1901895"(negative regulation of ATPase-coupled calcium transmembrane transporter activity)|go:"GO:1902350"(cellular response to chloroquine)|interpro:IPR000157(Toll-Interleukin receptor)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR027181|interpro:IPR035897|interpro:IPR041283|mint:Q9EQU3|rcsb pdb:3WPF|rcsb pdb:3WPG|rcsb pdb:3WPH|rcsb pdb:3WPI|go:"GO:0032725"(positive regulation of granulocyte macrophage colony-stimulating factor production)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032741"(positive regulation of interleukin-18 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0034122"(negative regulation of toll-like receptor signaling pathway)|go:"GO:0034123"(positive regulation of toll-like receptor signaling pathway)|go:"GO:0034162"(toll-like receptor 9 signaling pathway)|go:"GO:0034163"(regulation of toll-like receptor 9 signaling pathway)|go:"GO:0034165"(positive regulation of toll-like receptor 9 signaling pathway)|go:"GO:0035197"(siRNA binding)|go:"GO:0036019"(endolysosome)|go:"GO:0038187"(pattern recognition receptor activity)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0032722"(positive regulation of chemokine production)	refseq:NP_058828.2|rgd:3548|ensembl:ENSRNOG00000015780(gene)|ensembl:ENSRNOT00000021817(transcript)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005730"(nucleolus)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005788"(endoplasmic reticulum lumen)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|mint:Q62703	-	-	-	figure legend:sf1b|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat-fibroblast)|taxid:10116(Rattus norvegicus)	-	2014/11/18	2014/11/18	rogid:3XKXj7PkEGE5qOchJfjMHFREkT010090	rogid:6sN8PDsM+GbuhxWQ3bEBdedfY3g10116	intact-crc:C88D7A0095F1C09B|rigid:0+mGgaCkpwPWzk6WvbzxFSAVf9s	false	calmodulin binding peptide plus protein a tag:c-c	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9EQU3	uniprotkb:P42930	intact:EBI-9979528|ensembl:ENSMUSP00000082207|uniprotkb:F8VPN5|uniprotkb:Q4L0K3|uniprotkb:Q4L0K4|uniprotkb:Q99MF2|uniprotkb:Q99MQ8	intact:EBI-917489|uniprotkb:Q63922|uniprotkb:Q9QWA8	psi-mi:tlr9_mouse(display_long)|uniprotkb:Tlr9(gene name)|psi-mi:Tlr9(display_short)	psi-mi:hspb1_rat(display_long)|uniprotkb:Heat shock 27 kDa protein(gene name synonym)|uniprotkb:Hspb1(gene name)|psi-mi:Hspb1(display_short)|uniprotkb:Hsp27(gene name synonym)	psi-mi:"MI:0676"(tandem affinity purification)	Shintani et al. (2014)	imex:IM-23524|pubmed:24610369	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-9979662|imex:IM-23524-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000045322(gene)|ensembl:ENSMUST00000062241(transcript)|go:"GO:0001774"(microglial cell activation)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0002224"(toll-like receptor signaling pathway)|go:"GO:0002237"(response to molecule of bacterial origin)|go:"GO:0002639"(positive regulation of immunoglobulin production)|go:"GO:0002730"(regulation of dendritic cell cytokine production)|go:"GO:0002755"(MyD88-dependent toll-like receptor signaling pathway)|go:"GO:0005149"(interleukin-1 receptor binding)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|refseq:NP_112455.2|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0045087"(innate immune response)|go:"GO:0045322"(unmethylated CpG binding)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0045577"(regulation of B cell differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0050864"(regulation of B cell activation)|go:"GO:0050871"(positive regulation of B cell activation)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051607"(defense response to virus)|go:"GO:0051770"(positive regulation of nitric-oxide synthase biosynthetic process)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071248"(cellular response to metal ion)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:0005886"(plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0007252"(I-kappaB phosphorylation)|go:"GO:0008584"(male gonad development)|go:"GO:0009615"(response to virus)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030277"(maintenance of gastrointestinal epithelium)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0032009"(early phagosome)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032717"(negative regulation of interleukin-8 production)|go:"GO:0005789"(endoplasmic reticulum membrane)|rcsb pdb:4QDH|rcsb pdb:5ZLN|reactome:R-MMU-109704|reactome:R-MMU-1679131|reactome:R-MMU-168138|go:"GO:1901895"(negative regulation of ATPase-coupled calcium transmembrane transporter activity)|go:"GO:1902350"(cellular response to chloroquine)|interpro:IPR000157(Toll-Interleukin receptor)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR027181|interpro:IPR035897|interpro:IPR041283|mint:Q9EQU3|rcsb pdb:3WPF|rcsb pdb:3WPG|rcsb pdb:3WPH|rcsb pdb:3WPI|go:"GO:0032725"(positive regulation of granulocyte macrophage colony-stimulating factor production)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032741"(positive regulation of interleukin-18 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0034122"(negative regulation of toll-like receptor signaling pathway)|go:"GO:0034123"(positive regulation of toll-like receptor signaling pathway)|go:"GO:0034162"(toll-like receptor 9 signaling pathway)|go:"GO:0034163"(regulation of toll-like receptor 9 signaling pathway)|go:"GO:0034165"(positive regulation of toll-like receptor 9 signaling pathway)|go:"GO:0035197"(siRNA binding)|go:"GO:0036019"(endolysosome)|go:"GO:0038187"(pattern recognition receptor activity)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0032722"(positive regulation of chemokine production)	rgd:61306|interpro:IPR001436(Alpha crystallin/Heat shock protein)|interpro:IPR002068(Heat shock protein Hsp20)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR037876|mint:P42930|go:"GO:0000502"(proteasome complex)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0002931"(response to ischemia)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005819"(spindle)|go:"GO:0005886"(plasma membrane)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0007565"(female pregnancy)|go:"GO:0007568"(aging)|go:"GO:0008426"(protein kinase C inhibitor activity)|go:"GO:0009615"(response to virus)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030018"(Z disc)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031430"(M band)|go:"GO:0031674"(I band)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|go:"GO:0035994"(response to muscle stretch)|go:"GO:0038033"(positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043292"(contractile fiber)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0045202"(synapse)|go:"GO:0045590"(negative regulation of regulatory T cell differentiation)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0061077"(chaperone-mediated protein folding)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0071348"(cellular response to interleukin-11)|go:"GO:0097512"(cardiac myofibril)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0099641"(anterograde axonal protein transport)|go:"GO:1902176"(negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1903202"(negative regulation of oxidative stress-induced cell death)|go:"GO:1903545"(cellular response to butyrate)|go:"GO:1904115"(axon cytoplasm)|go:"GO:1990776"(response to angiotensin)|go:"GO:2001028"(positive regulation of endothelial cell chemotaxis)|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|reactome:R-RNO-4420097|reactome:R-RNO-450408|reactome:R-RNO-5687128|reactome:R-RNO-9009391	-	-	-	figure legend:sf1b|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat-fibroblast)|taxid:10116(Rattus norvegicus)	-	2014/11/18	2014/11/18	rogid:3XKXj7PkEGE5qOchJfjMHFREkT010090	rogid:4VkGr8nFFRoQa+1RiEto9b3gIv410116	intact-crc:C88D7A0095F1C09B|rigid:0+mGgaCkpwPWzk6WvbzxFSAVf9s	false	calmodulin binding peptide plus protein a tag:c-c	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9EQU3	uniprotkb:P62864	intact:EBI-9979528|ensembl:ENSMUSP00000082207|uniprotkb:F8VPN5|uniprotkb:Q4L0K3|uniprotkb:Q4L0K4|uniprotkb:Q99MF2|uniprotkb:Q99MQ8	intact:EBI-9979498|uniprotkb:Q05472|uniprotkb:Q95261	psi-mi:tlr9_mouse(display_long)|uniprotkb:Tlr9(gene name)|psi-mi:Tlr9(display_short)	psi-mi:rs30_rat(display_long)|uniprotkb:Fau(gene name)|psi-mi:Fau(display_short)	psi-mi:"MI:0676"(tandem affinity purification)	Shintani et al. (2014)	imex:IM-23524|pubmed:24610369	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-9979662|imex:IM-23524-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000045322(gene)|ensembl:ENSMUST00000062241(transcript)|go:"GO:0001774"(microglial cell activation)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0002224"(toll-like receptor signaling pathway)|go:"GO:0002237"(response to molecule of bacterial origin)|go:"GO:0002639"(positive regulation of immunoglobulin production)|go:"GO:0002730"(regulation of dendritic cell cytokine production)|go:"GO:0002755"(MyD88-dependent toll-like receptor signaling pathway)|go:"GO:0005149"(interleukin-1 receptor binding)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|refseq:NP_112455.2|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0045087"(innate immune response)|go:"GO:0045322"(unmethylated CpG binding)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0045577"(regulation of B cell differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0050864"(regulation of B cell activation)|go:"GO:0050871"(positive regulation of B cell activation)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051607"(defense response to virus)|go:"GO:0051770"(positive regulation of nitric-oxide synthase biosynthetic process)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071248"(cellular response to metal ion)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:0005886"(plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0007252"(I-kappaB phosphorylation)|go:"GO:0008584"(male gonad development)|go:"GO:0009615"(response to virus)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030277"(maintenance of gastrointestinal epithelium)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0032009"(early phagosome)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032717"(negative regulation of interleukin-8 production)|go:"GO:0005789"(endoplasmic reticulum membrane)|rcsb pdb:4QDH|rcsb pdb:5ZLN|reactome:R-MMU-109704|reactome:R-MMU-1679131|reactome:R-MMU-168138|go:"GO:1901895"(negative regulation of ATPase-coupled calcium transmembrane transporter activity)|go:"GO:1902350"(cellular response to chloroquine)|interpro:IPR000157(Toll-Interleukin receptor)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR027181|interpro:IPR035897|interpro:IPR041283|mint:Q9EQU3|rcsb pdb:3WPF|rcsb pdb:3WPG|rcsb pdb:3WPH|rcsb pdb:3WPI|go:"GO:0032725"(positive regulation of granulocyte macrophage colony-stimulating factor production)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032741"(positive regulation of interleukin-18 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0034122"(negative regulation of toll-like receptor signaling pathway)|go:"GO:0034123"(positive regulation of toll-like receptor signaling pathway)|go:"GO:0034162"(toll-like receptor 9 signaling pathway)|go:"GO:0034163"(regulation of toll-like receptor 9 signaling pathway)|go:"GO:0034165"(positive regulation of toll-like receptor 9 signaling pathway)|go:"GO:0035197"(siRNA binding)|go:"GO:0036019"(endolysosome)|go:"GO:0038187"(pattern recognition receptor activity)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0032722"(positive regulation of chemokine production)	go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005840"(ribosome)|go:"GO:0006412"(translation)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|interpro:IPR006846(Ribosomal protein S30)|rgd:61938|mint:P62864	-	-	-	figure legend:sf1b|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat-fibroblast)|taxid:10116(Rattus norvegicus)	-	2014/11/18	2014/11/18	rogid:3XKXj7PkEGE5qOchJfjMHFREkT010090	rogid:mfW+tko85h9ZOK7wNXUsYiYY3Hc10116	intact-crc:C88D7A0095F1C09B|rigid:0+mGgaCkpwPWzk6WvbzxFSAVf9s	false	calmodulin binding peptide plus protein a tag:c-c	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9EQU3	uniprotkb:P35565	intact:EBI-9979528|ensembl:ENSMUSP00000082207|uniprotkb:F8VPN5|uniprotkb:Q4L0K3|uniprotkb:Q4L0K4|uniprotkb:Q99MF2|uniprotkb:Q99MQ8	intact:EBI-917363|ensembl:ENSRNOP00000040859	psi-mi:tlr9_mouse(display_long)|uniprotkb:Tlr9(gene name)|psi-mi:Tlr9(display_short)	psi-mi:calx_rat(display_long)|uniprotkb:Canx(gene name)|psi-mi:Canx(display_short)	psi-mi:"MI:0676"(tandem affinity purification)	Shintani et al. (2014)	imex:IM-23524|pubmed:24610369	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-9979662|imex:IM-23524-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000045322(gene)|ensembl:ENSMUST00000062241(transcript)|go:"GO:0001774"(microglial cell activation)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0002224"(toll-like receptor signaling pathway)|go:"GO:0002237"(response to molecule of bacterial origin)|go:"GO:0002639"(positive regulation of immunoglobulin production)|go:"GO:0002730"(regulation of dendritic cell cytokine production)|go:"GO:0002755"(MyD88-dependent toll-like receptor signaling pathway)|go:"GO:0005149"(interleukin-1 receptor binding)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|refseq:NP_112455.2|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0045087"(innate immune response)|go:"GO:0045322"(unmethylated CpG binding)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0045577"(regulation of B cell differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0050864"(regulation of B cell activation)|go:"GO:0050871"(positive regulation of B cell activation)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051607"(defense response to virus)|go:"GO:0051770"(positive regulation of nitric-oxide synthase biosynthetic process)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071248"(cellular response to metal ion)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:0005886"(plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0007252"(I-kappaB phosphorylation)|go:"GO:0008584"(male gonad development)|go:"GO:0009615"(response to virus)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030277"(maintenance of gastrointestinal epithelium)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0032009"(early phagosome)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032717"(negative regulation of interleukin-8 production)|go:"GO:0005789"(endoplasmic reticulum membrane)|rcsb pdb:4QDH|rcsb pdb:5ZLN|reactome:R-MMU-109704|reactome:R-MMU-1679131|reactome:R-MMU-168138|go:"GO:1901895"(negative regulation of ATPase-coupled calcium transmembrane transporter activity)|go:"GO:1902350"(cellular response to chloroquine)|interpro:IPR000157(Toll-Interleukin receptor)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR027181|interpro:IPR035897|interpro:IPR041283|mint:Q9EQU3|rcsb pdb:3WPF|rcsb pdb:3WPG|rcsb pdb:3WPH|rcsb pdb:3WPI|go:"GO:0032725"(positive regulation of granulocyte macrophage colony-stimulating factor production)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032741"(positive regulation of interleukin-18 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0034122"(negative regulation of toll-like receptor signaling pathway)|go:"GO:0034123"(positive regulation of toll-like receptor signaling pathway)|go:"GO:0034162"(toll-like receptor 9 signaling pathway)|go:"GO:0034163"(regulation of toll-like receptor 9 signaling pathway)|go:"GO:0034165"(positive regulation of toll-like receptor 9 signaling pathway)|go:"GO:0035197"(siRNA binding)|go:"GO:0036019"(endolysosome)|go:"GO:0038187"(pattern recognition receptor activity)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0032722"(positive regulation of chemokine production)	rgd:2266|refseq:NP_742005.1|refseq:XP_008765901.1|refseq:XP_008765902.1|ensembl:ENSRNOG00000003343(gene)|ensembl:ENSRNOT00000049942(transcript)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005840"(ribosome)|go:"GO:0006457"(protein folding)|go:"GO:0007568"(aging)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0030424"(axon)|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034185"(apolipoprotein binding)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0042470"(melanosome)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0044233"(mitochondria-associated endoplasmic reticulum membrane)|go:"GO:0044322"(endoplasmic reticulum quality control compartment)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0072583"(clathrin-dependent endocytosis)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099059"(integral component of presynaptic active zone membrane)|interpro:IPR001580(Calreticulin/calnexin)|interpro:IPR009033(Calreticulin/calnexin, P)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR018124|mint:P35565|reactome:R-RNO-2132295|reactome:R-RNO-901042|reactome:R-RNO-9020956|reactome:R-RNO-983170	-	-	-	figure legend:sf1b|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat-fibroblast)|taxid:10116(Rattus norvegicus)	-	2014/11/18	2014/11/18	rogid:3XKXj7PkEGE5qOchJfjMHFREkT010090	rogid:OA7gJ6oMBN6zraU38Xg856XebR810116	intact-crc:C88D7A0095F1C09B|rigid:0+mGgaCkpwPWzk6WvbzxFSAVf9s	false	calmodulin binding peptide plus protein a tag:c-c	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9EQU3	uniprotkb:P41123	intact:EBI-9979528|ensembl:ENSMUSP00000082207|uniprotkb:F8VPN5|uniprotkb:Q4L0K3|uniprotkb:Q4L0K4|uniprotkb:Q99MF2|uniprotkb:Q99MQ8	intact:EBI-917471|ensembl:ENSRNOP00000020635	psi-mi:tlr9_mouse(display_long)|uniprotkb:Tlr9(gene name)|psi-mi:Tlr9(display_short)	psi-mi:rl13_rat(display_long)|uniprotkb:Rpl13(gene name)|psi-mi:Rpl13(display_short)	psi-mi:"MI:0676"(tandem affinity purification)	Shintani et al. (2014)	imex:IM-23524|pubmed:24610369	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-9979662|imex:IM-23524-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000045322(gene)|ensembl:ENSMUST00000062241(transcript)|go:"GO:0001774"(microglial cell activation)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0002224"(toll-like receptor signaling pathway)|go:"GO:0002237"(response to molecule of bacterial origin)|go:"GO:0002639"(positive regulation of immunoglobulin production)|go:"GO:0002730"(regulation of dendritic cell cytokine production)|go:"GO:0002755"(MyD88-dependent toll-like receptor signaling pathway)|go:"GO:0005149"(interleukin-1 receptor binding)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|refseq:NP_112455.2|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0045087"(innate immune response)|go:"GO:0045322"(unmethylated CpG binding)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0045577"(regulation of B cell differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0050864"(regulation of B cell activation)|go:"GO:0050871"(positive regulation of B cell activation)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051607"(defense response to virus)|go:"GO:0051770"(positive regulation of nitric-oxide synthase biosynthetic process)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071248"(cellular response to metal ion)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:0005886"(plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0007252"(I-kappaB phosphorylation)|go:"GO:0008584"(male gonad development)|go:"GO:0009615"(response to virus)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030277"(maintenance of gastrointestinal epithelium)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0032009"(early phagosome)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032717"(negative regulation of interleukin-8 production)|go:"GO:0005789"(endoplasmic reticulum membrane)|rcsb pdb:4QDH|rcsb pdb:5ZLN|reactome:R-MMU-109704|reactome:R-MMU-1679131|reactome:R-MMU-168138|go:"GO:1901895"(negative regulation of ATPase-coupled calcium transmembrane transporter activity)|go:"GO:1902350"(cellular response to chloroquine)|interpro:IPR000157(Toll-Interleukin receptor)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR027181|interpro:IPR035897|interpro:IPR041283|mint:Q9EQU3|rcsb pdb:3WPF|rcsb pdb:3WPG|rcsb pdb:3WPH|rcsb pdb:3WPI|go:"GO:0032725"(positive regulation of granulocyte macrophage colony-stimulating factor production)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032741"(positive regulation of interleukin-18 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0034122"(negative regulation of toll-like receptor signaling pathway)|go:"GO:0034123"(positive regulation of toll-like receptor signaling pathway)|go:"GO:0034162"(toll-like receptor 9 signaling pathway)|go:"GO:0034163"(regulation of toll-like receptor 9 signaling pathway)|go:"GO:0034165"(positive regulation of toll-like receptor 9 signaling pathway)|go:"GO:0035197"(siRNA binding)|go:"GO:0036019"(endolysosome)|go:"GO:0038187"(pattern recognition receptor activity)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0032722"(positive regulation of chemokine production)	rgd:621179|refseq:NP_112363.1|ensembl:ENSRNOG00000015335(gene)|ensembl:ENSRNOT00000020635(transcript)|go:"GO:0001824"(blastocyst development)|go:"GO:0003723"(RNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0006412"(translation)|go:"GO:0022625"(cytosolic large ribosomal subunit)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0060348"(bone development)|go:"GO:0097421"(liver regeneration)|interpro:IPR001380(Ribosomal protein L13e)|interpro:IPR018256|mint:P41123|reactome:R-RNO-156827|reactome:R-RNO-1799339|reactome:R-RNO-6791226|reactome:R-RNO-72689|reactome:R-RNO-72706|reactome:R-RNO-975956|reactome:R-RNO-975957	-	-	-	figure legend:sf1b|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat-fibroblast)|taxid:10116(Rattus norvegicus)	-	2014/11/18	2014/11/18	rogid:3XKXj7PkEGE5qOchJfjMHFREkT010090	rogid:VaQ1k6Ys24FJswxJBjygrPBW8JE10116	intact-crc:C88D7A0095F1C09B|rigid:0+mGgaCkpwPWzk6WvbzxFSAVf9s	false	calmodulin binding peptide plus protein a tag:c-c	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9EQU3	uniprotkb:Q6TUG0	intact:EBI-9979528|ensembl:ENSMUSP00000082207|uniprotkb:F8VPN5|uniprotkb:Q4L0K3|uniprotkb:Q4L0K4|uniprotkb:Q99MF2|uniprotkb:Q99MQ8	intact:EBI-919258|ensembl:ENSRNOP00000002462	psi-mi:tlr9_mouse(display_long)|uniprotkb:Tlr9(gene name)|psi-mi:Tlr9(display_short)	psi-mi:djb11_rat(display_long)|uniprotkb:Dnajb11(gene name)|psi-mi:Dnajb11(display_short)|uniprotkb:ER-associated Hsp40 co-chaperone(gene name synonym)|uniprotkb:ER-associated DNAJ(gene name synonym)|uniprotkb:Liver regeneration-related protein LRRGT00084(gene name synonym)|uniprotkb:Endoplasmic reticulum DNA J domain-containing protein 3(gene name synonym)	psi-mi:"MI:0676"(tandem affinity purification)	Shintani et al. (2014)	imex:IM-23524|pubmed:24610369	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-9979662|imex:IM-23524-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000045322(gene)|ensembl:ENSMUST00000062241(transcript)|go:"GO:0001774"(microglial cell activation)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0002224"(toll-like receptor signaling pathway)|go:"GO:0002237"(response to molecule of bacterial origin)|go:"GO:0002639"(positive regulation of immunoglobulin production)|go:"GO:0002730"(regulation of dendritic cell cytokine production)|go:"GO:0002755"(MyD88-dependent toll-like receptor signaling pathway)|go:"GO:0005149"(interleukin-1 receptor binding)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|refseq:NP_112455.2|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0045087"(innate immune response)|go:"GO:0045322"(unmethylated CpG binding)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0045577"(regulation of B cell differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0050864"(regulation of B cell activation)|go:"GO:0050871"(positive regulation of B cell activation)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051607"(defense response to virus)|go:"GO:0051770"(positive regulation of nitric-oxide synthase biosynthetic process)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071248"(cellular response to metal ion)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:0005886"(plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0007252"(I-kappaB phosphorylation)|go:"GO:0008584"(male gonad development)|go:"GO:0009615"(response to virus)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030277"(maintenance of gastrointestinal epithelium)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0032009"(early phagosome)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032717"(negative regulation of interleukin-8 production)|go:"GO:0005789"(endoplasmic reticulum membrane)|rcsb pdb:4QDH|rcsb pdb:5ZLN|reactome:R-MMU-109704|reactome:R-MMU-1679131|reactome:R-MMU-168138|go:"GO:1901895"(negative regulation of ATPase-coupled calcium transmembrane transporter activity)|go:"GO:1902350"(cellular response to chloroquine)|interpro:IPR000157(Toll-Interleukin receptor)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR027181|interpro:IPR035897|interpro:IPR041283|mint:Q9EQU3|rcsb pdb:3WPF|rcsb pdb:3WPG|rcsb pdb:3WPH|rcsb pdb:3WPI|go:"GO:0032725"(positive regulation of granulocyte macrophage colony-stimulating factor production)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032741"(positive regulation of interleukin-18 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0034122"(negative regulation of toll-like receptor signaling pathway)|go:"GO:0034123"(positive regulation of toll-like receptor signaling pathway)|go:"GO:0034162"(toll-like receptor 9 signaling pathway)|go:"GO:0034163"(regulation of toll-like receptor 9 signaling pathway)|go:"GO:0034165"(positive regulation of toll-like receptor 9 signaling pathway)|go:"GO:0035197"(siRNA binding)|go:"GO:0036019"(endolysosome)|go:"GO:0038187"(pattern recognition receptor activity)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0032722"(positive regulation of chemokine production)	rgd:1307373|refseq:NP_001015021.1|ensembl:ENSRNOG00000001803(gene)|ensembl:ENSRNOT00000002462(transcript)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0006457"(protein folding)|go:"GO:0016556"(mRNA modification)|go:"GO:0032781"(positive regulation of ATP-dependent activity)|go:"GO:0034663"(endoplasmic reticulum chaperone complex)|go:"GO:0050768"(negative regulation of neurogenesis)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051604"(protein maturation)|go:"GO:0051787"(misfolded protein binding)|go:"GO:0101031"(chaperone complex)|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR002939(Chaperone DnaJ, C-terminal)|interpro:IPR008971(HSP40/DnaJ peptide-binding)|interpro:IPR018253|interpro:IPR036869|mint:Q6TUG0	-	-	-	figure legend:sf1b|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat-fibroblast)|taxid:10116(Rattus norvegicus)	-	2014/11/18	2014/11/18	rogid:3XKXj7PkEGE5qOchJfjMHFREkT010090	rogid:NMsvYKrs7f8hoFUT68Xt5cEHnDU10116	intact-crc:C88D7A0095F1C09B|rigid:0+mGgaCkpwPWzk6WvbzxFSAVf9s	false	calmodulin binding peptide plus protein a tag:c-c	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9EQU3	uniprotkb:P23928	intact:EBI-9979528|ensembl:ENSMUSP00000082207|uniprotkb:F8VPN5|uniprotkb:Q4L0K3|uniprotkb:Q4L0K4|uniprotkb:Q99MF2|uniprotkb:Q99MQ8	intact:EBI-916888|uniprotkb:Q6LDR2|ensembl:ENSRNOP00000055901	psi-mi:tlr9_mouse(display_long)|uniprotkb:Tlr9(gene name)|psi-mi:Tlr9(display_short)	psi-mi:cryab_rat(display_long)|uniprotkb:"Alpha(B)-crystallin"(gene name synonym)|uniprotkb:Cryab(gene name)|psi-mi:Cryab(display_short)	psi-mi:"MI:0676"(tandem affinity purification)	Shintani et al. (2014)	imex:IM-23524|pubmed:24610369	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-9979662|imex:IM-23524-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000045322(gene)|ensembl:ENSMUST00000062241(transcript)|go:"GO:0001774"(microglial cell activation)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0002224"(toll-like receptor signaling pathway)|go:"GO:0002237"(response to molecule of bacterial origin)|go:"GO:0002639"(positive regulation of immunoglobulin production)|go:"GO:0002730"(regulation of dendritic cell cytokine production)|go:"GO:0002755"(MyD88-dependent toll-like receptor signaling pathway)|go:"GO:0005149"(interleukin-1 receptor binding)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|refseq:NP_112455.2|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0045087"(innate immune response)|go:"GO:0045322"(unmethylated CpG binding)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0045577"(regulation of B cell differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0050864"(regulation of B cell activation)|go:"GO:0050871"(positive regulation of B cell activation)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051607"(defense response to virus)|go:"GO:0051770"(positive regulation of nitric-oxide synthase biosynthetic process)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071248"(cellular response to metal ion)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:0005886"(plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0007252"(I-kappaB phosphorylation)|go:"GO:0008584"(male gonad development)|go:"GO:0009615"(response to virus)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030277"(maintenance of gastrointestinal epithelium)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0032009"(early phagosome)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032717"(negative regulation of interleukin-8 production)|go:"GO:0005789"(endoplasmic reticulum membrane)|rcsb pdb:4QDH|rcsb pdb:5ZLN|reactome:R-MMU-109704|reactome:R-MMU-1679131|reactome:R-MMU-168138|go:"GO:1901895"(negative regulation of ATPase-coupled calcium transmembrane transporter activity)|go:"GO:1902350"(cellular response to chloroquine)|interpro:IPR000157(Toll-Interleukin receptor)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR027181|interpro:IPR035897|interpro:IPR041283|mint:Q9EQU3|rcsb pdb:3WPF|rcsb pdb:3WPG|rcsb pdb:3WPH|rcsb pdb:3WPI|go:"GO:0032725"(positive regulation of granulocyte macrophage colony-stimulating factor production)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032741"(positive regulation of interleukin-18 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0034122"(negative regulation of toll-like receptor signaling pathway)|go:"GO:0034123"(positive regulation of toll-like receptor signaling pathway)|go:"GO:0034162"(toll-like receptor 9 signaling pathway)|go:"GO:0034163"(regulation of toll-like receptor 9 signaling pathway)|go:"GO:0034165"(positive regulation of toll-like receptor 9 signaling pathway)|go:"GO:0035197"(siRNA binding)|go:"GO:0036019"(endolysosome)|go:"GO:0038187"(pattern recognition receptor activity)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0032722"(positive regulation of chemokine production)	rgd:2414|refseq:NP_037067.1|ensembl:ENSRNOG00000010524(gene)|ensembl:ENSRNOT00000059127(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002088"(lens development in camera-type eye)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005212"(structural constituent of eye lens)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006457"(protein folding)|go:"GO:0007021"(tubulin complex assembly)|go:"GO:0007517"(muscle organ development)|go:"GO:0007568"(aging)|go:"GO:0008017"(microtubule binding)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0009986"(cell surface)|go:"GO:0010259"(multicellular organism aging)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010941"(regulation of cell death)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0030018"(Z disc)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030424"(axon)|go:"GO:0031109"(microtubule polymerization or depolymerization)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0031430"(M band)|go:"GO:0031674"(I band)|go:"GO:0032355"(response to estradiol)|go:"GO:0032387"(negative regulation of intracellular transport)|go:"GO:0032432"(actin filament bundle)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043010"(camera-type eye development)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043197"(dendritic spine)|go:"GO:0043204"(perikaryon)|go:"GO:0043292"(contractile fiber)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046872"(metal ion binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051403"(stress-activated MAPK cascade)|go:"GO:0060561"(apoptotic process involved in morphogenesis)|go:"GO:0071480"(cellular response to gamma radiation)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097512"(cardiac myofibril)|go:"GO:1905907"(negative regulation of amyloid fibril formation)|go:"GO:2000378"(negative regulation of reactive oxygen species metabolic process)|interpro:IPR001436(Alpha crystallin/Heat shock protein)|interpro:IPR002068(Heat shock protein Hsp20)|interpro:IPR003090(Alpha-crystallin, N-terminal)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR037882|mint:P23928|reactome:R-RNO-3371571	-	-	-	figure legend:sf1b|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat-fibroblast)|taxid:10116(Rattus norvegicus)	-	2014/11/18	2014/11/18	rogid:3XKXj7PkEGE5qOchJfjMHFREkT010090	rogid:WVFpAMy4PxYCruNm6Y0UT6+kAmo10116	intact-crc:C88D7A0095F1C09B|rigid:0+mGgaCkpwPWzk6WvbzxFSAVf9s	false	calmodulin binding peptide plus protein a tag:c-c	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9EQU3	uniprotkb:Q9Z142	intact:EBI-9979528|ensembl:ENSMUSP00000082207|uniprotkb:F8VPN5|uniprotkb:Q4L0K3|uniprotkb:Q4L0K4|uniprotkb:Q99MF2|uniprotkb:Q99MQ8	intact:EBI-9979483	psi-mi:tlr9_mouse(display_long)|uniprotkb:Tlr9(gene name)|psi-mi:Tlr9(display_short)	psi-mi:tmm33_rat(display_long)|uniprotkb:Tmem33(gene name)|psi-mi:Tmem33(display_short)|uniprotkb:Db83(gene name synonym)|uniprotkb:Protein DB83(gene name synonym)	psi-mi:"MI:0676"(tandem affinity purification)	Shintani et al. (2014)	imex:IM-23524|pubmed:24610369	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-9979662|imex:IM-23524-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000045322(gene)|ensembl:ENSMUST00000062241(transcript)|go:"GO:0001774"(microglial cell activation)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0002224"(toll-like receptor signaling pathway)|go:"GO:0002237"(response to molecule of bacterial origin)|go:"GO:0002639"(positive regulation of immunoglobulin production)|go:"GO:0002730"(regulation of dendritic cell cytokine production)|go:"GO:0002755"(MyD88-dependent toll-like receptor signaling pathway)|go:"GO:0005149"(interleukin-1 receptor binding)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|refseq:NP_112455.2|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0045087"(innate immune response)|go:"GO:0045322"(unmethylated CpG binding)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0045577"(regulation of B cell differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0050864"(regulation of B cell activation)|go:"GO:0050871"(positive regulation of B cell activation)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051607"(defense response to virus)|go:"GO:0051770"(positive regulation of nitric-oxide synthase biosynthetic process)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071248"(cellular response to metal ion)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:0005886"(plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0007252"(I-kappaB phosphorylation)|go:"GO:0008584"(male gonad development)|go:"GO:0009615"(response to virus)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030277"(maintenance of gastrointestinal epithelium)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0032009"(early phagosome)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032717"(negative regulation of interleukin-8 production)|go:"GO:0005789"(endoplasmic reticulum membrane)|rcsb pdb:4QDH|rcsb pdb:5ZLN|reactome:R-MMU-109704|reactome:R-MMU-1679131|reactome:R-MMU-168138|go:"GO:1901895"(negative regulation of ATPase-coupled calcium transmembrane transporter activity)|go:"GO:1902350"(cellular response to chloroquine)|interpro:IPR000157(Toll-Interleukin receptor)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR027181|interpro:IPR035897|interpro:IPR041283|mint:Q9EQU3|rcsb pdb:3WPF|rcsb pdb:3WPG|rcsb pdb:3WPH|rcsb pdb:3WPI|go:"GO:0032725"(positive regulation of granulocyte macrophage colony-stimulating factor production)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032741"(positive regulation of interleukin-18 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0034122"(negative regulation of toll-like receptor signaling pathway)|go:"GO:0034123"(positive regulation of toll-like receptor signaling pathway)|go:"GO:0034162"(toll-like receptor 9 signaling pathway)|go:"GO:0034163"(regulation of toll-like receptor 9 signaling pathway)|go:"GO:0034165"(positive regulation of toll-like receptor 9 signaling pathway)|go:"GO:0035197"(siRNA binding)|go:"GO:0036019"(endolysosome)|go:"GO:0038187"(pattern recognition receptor activity)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0032722"(positive regulation of chemokine production)	go:"GO:0005635"(nuclear envelope)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0042470"(melanosome)|go:"GO:0061024"(membrane organization)|go:"GO:0071786"(endoplasmic reticulum tubular network organization)|go:"GO:1903371"(regulation of endoplasmic reticulum tubular network organization)|go:"GO:1903896"(positive regulation of IRE1-mediated unfolded protein response)|go:"GO:1903899"(positive regulation of PERK-mediated unfolded protein response)|refseq:NP_067703.1|interpro:IPR005344(Protein of unknown function UPF0121)|rgd:708371|mint:Q9Z142	-	-	-	figure legend:sf1b|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat-fibroblast)|taxid:10116(Rattus norvegicus)	-	2014/11/18	2014/11/18	rogid:3XKXj7PkEGE5qOchJfjMHFREkT010090	rogid:PcG/OnnTN84P2xlZPzcI5j+QYRo10116	intact-crc:C88D7A0095F1C09B|rigid:0+mGgaCkpwPWzk6WvbzxFSAVf9s	false	calmodulin binding peptide plus protein a tag:c-c	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9EQU3	uniprotkb:P10719	intact:EBI-9979528|ensembl:ENSMUSP00000082207|uniprotkb:F8VPN5|uniprotkb:Q4L0K3|uniprotkb:Q4L0K4|uniprotkb:Q99MF2|uniprotkb:Q99MQ8	intact:EBI-916266|uniprotkb:Q499W0	psi-mi:tlr9_mouse(display_long)|uniprotkb:Tlr9(gene name)|psi-mi:Tlr9(display_short)	psi-mi:atpb_rat(display_long)|uniprotkb:Atp5f1b(gene name)|psi-mi:Atp5f1b(display_short)|uniprotkb:ATP synthase F1 subunit beta(gene name synonym)|uniprotkb:Atp5b(gene name synonym)	psi-mi:"MI:0676"(tandem affinity purification)	Shintani et al. (2014)	imex:IM-23524|pubmed:24610369	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-9979662|imex:IM-23524-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000045322(gene)|ensembl:ENSMUST00000062241(transcript)|go:"GO:0001774"(microglial cell activation)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0002224"(toll-like receptor signaling pathway)|go:"GO:0002237"(response to molecule of bacterial origin)|go:"GO:0002639"(positive regulation of immunoglobulin production)|go:"GO:0002730"(regulation of dendritic cell cytokine production)|go:"GO:0002755"(MyD88-dependent toll-like receptor signaling pathway)|go:"GO:0005149"(interleukin-1 receptor binding)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|refseq:NP_112455.2|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0045087"(innate immune response)|go:"GO:0045322"(unmethylated CpG binding)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0045577"(regulation of B cell differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0050864"(regulation of B cell activation)|go:"GO:0050871"(positive regulation of B cell activation)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051607"(defense response to virus)|go:"GO:0051770"(positive regulation of nitric-oxide synthase biosynthetic process)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071248"(cellular response to metal ion)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:0005886"(plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0007252"(I-kappaB phosphorylation)|go:"GO:0008584"(male gonad development)|go:"GO:0009615"(response to virus)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030277"(maintenance of gastrointestinal epithelium)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0032009"(early phagosome)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032717"(negative regulation of interleukin-8 production)|go:"GO:0005789"(endoplasmic reticulum membrane)|rcsb pdb:4QDH|rcsb pdb:5ZLN|reactome:R-MMU-109704|reactome:R-MMU-1679131|reactome:R-MMU-168138|go:"GO:1901895"(negative regulation of ATPase-coupled calcium transmembrane transporter activity)|go:"GO:1902350"(cellular response to chloroquine)|interpro:IPR000157(Toll-Interleukin receptor)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR027181|interpro:IPR035897|interpro:IPR041283|mint:Q9EQU3|rcsb pdb:3WPF|rcsb pdb:3WPG|rcsb pdb:3WPH|rcsb pdb:3WPI|go:"GO:0032725"(positive regulation of granulocyte macrophage colony-stimulating factor production)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032741"(positive regulation of interleukin-18 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0034122"(negative regulation of toll-like receptor signaling pathway)|go:"GO:0034123"(positive regulation of toll-like receptor signaling pathway)|go:"GO:0034162"(toll-like receptor 9 signaling pathway)|go:"GO:0034163"(regulation of toll-like receptor 9 signaling pathway)|go:"GO:0034165"(positive regulation of toll-like receptor 9 signaling pathway)|go:"GO:0035197"(siRNA binding)|go:"GO:0036019"(endolysosome)|go:"GO:0038187"(pattern recognition receptor activity)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0032722"(positive regulation of chemokine production)	rgd:621368|refseq:NP_599191.1|interpro:IPR020003|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR004100(ATPase, F1/V1/A1 complex, alpha/beta subunit, N-terminal)|interpro:IPR000194(ATPase, F1/V1/A1 complex, alpha/beta subunit, nucleotide-binding)|interpro:IPR024034|interpro:IPR005722(ATPase, F1 complex, beta subunit)|go:"GO:0000275"("mitochondrial proton-transporting ATP synthase complex, catalytic sector F(1)")|go:"GO:0001525"(angiogenesis)|go:"GO:0001889"(liver development)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005753"(mitochondrial proton-transporting ATP synthase complex)|go:"GO:0005886"(plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0006754"(ATP biosynthetic process)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0006933"(negative regulation of cell adhesion involved in substrate-bound cell migration)|go:"GO:0009631"(cold acclimation)|go:"GO:0009986"(cell surface)|go:"GO:0010042"(response to manganese ion)|go:"GO:0016020"(membrane)|go:"GO:0030228"(lipoprotein particle receptor activity)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0042288"(MHC class I protein binding)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0042776"(mitochondrial ATP synthesis coupled proton transport)|go:"GO:0043531"(ADP binding)|go:"GO:0043532"(angiostatin binding)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0045121"(membrane raft)|go:"GO:0045259"(proton-transporting ATP synthase complex)|go:"GO:0045261"("proton-transporting ATP synthase complex, catalytic core F(1)")|go:"GO:0046034"(ATP metabolic process)|go:"GO:0046933"(proton-transporting ATP synthase activity, rotational mechanism)|go:"GO:0046961"(proton-transporting ATPase activity, rotational mechanism)|go:"GO:0051453"(regulation of intracellular pH)|go:"GO:0098761"(cellular response to interleukin-7)|go:"GO:1901653"(cellular response to peptide)|go:"GO:1902600"(proton transmembrane transport)|go:"GO:1904643"(response to curcumin)|go:"GO:1905242"(response to 3,3',5-triiodo-L-thyronine)|rcsb pdb:1MAB|rcsb pdb:2F43|reactome:R-RNO-1268020|reactome:R-RNO-163210|reactome:R-RNO-8949613|interpro:IPR027417|mint:P10719|interpro:IPR036121	-	-	-	figure legend:sf1b|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat-fibroblast)|taxid:10116(Rattus norvegicus)	-	2014/11/18	2014/11/18	rogid:3XKXj7PkEGE5qOchJfjMHFREkT010090	rogid:K1RREEkTYSnEnU2leNpq3SCa3wc10116	intact-crc:C88D7A0095F1C09B|rigid:0+mGgaCkpwPWzk6WvbzxFSAVf9s	false	calmodulin binding peptide plus protein a tag:c-c	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9EQU3	uniprotkb:P63018	intact:EBI-9979528|ensembl:ENSMUSP00000082207|uniprotkb:F8VPN5|uniprotkb:Q4L0K3|uniprotkb:Q4L0K4|uniprotkb:Q99MF2|uniprotkb:Q99MQ8	intact:EBI-433431|uniprotkb:P08109|uniprotkb:P12225|uniprotkb:Q4FZY7|uniprotkb:Q62373|uniprotkb:Q62374|uniprotkb:Q62375	psi-mi:tlr9_mouse(display_long)|uniprotkb:Tlr9(gene name)|psi-mi:Tlr9(display_short)	psi-mi:hsp7c_rat(display_long)|uniprotkb:Hspa8(gene name)|psi-mi:Hspa8(display_short)|uniprotkb:Hsc70(gene name synonym)|uniprotkb:Heat shock 70 kDa protein 8(gene name synonym)|uniprotkb:Hsc73(gene name synonym)	psi-mi:"MI:0676"(tandem affinity purification)	Shintani et al. (2014)	imex:IM-23524|pubmed:24610369	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-9979662|imex:IM-23524-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000045322(gene)|ensembl:ENSMUST00000062241(transcript)|go:"GO:0001774"(microglial cell activation)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0002224"(toll-like receptor signaling pathway)|go:"GO:0002237"(response to molecule of bacterial origin)|go:"GO:0002639"(positive regulation of immunoglobulin production)|go:"GO:0002730"(regulation of dendritic cell cytokine production)|go:"GO:0002755"(MyD88-dependent toll-like receptor signaling pathway)|go:"GO:0005149"(interleukin-1 receptor binding)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|refseq:NP_112455.2|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0045087"(innate immune response)|go:"GO:0045322"(unmethylated CpG binding)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0045577"(regulation of B cell differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0050864"(regulation of B cell activation)|go:"GO:0050871"(positive regulation of B cell activation)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051607"(defense response to virus)|go:"GO:0051770"(positive regulation of nitric-oxide synthase biosynthetic process)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071248"(cellular response to metal ion)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:0005886"(plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0007252"(I-kappaB phosphorylation)|go:"GO:0008584"(male gonad development)|go:"GO:0009615"(response to virus)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030277"(maintenance of gastrointestinal epithelium)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0032009"(early phagosome)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032717"(negative regulation of interleukin-8 production)|go:"GO:0005789"(endoplasmic reticulum membrane)|rcsb pdb:4QDH|rcsb pdb:5ZLN|reactome:R-MMU-109704|reactome:R-MMU-1679131|reactome:R-MMU-168138|go:"GO:1901895"(negative regulation of ATPase-coupled calcium transmembrane transporter activity)|go:"GO:1902350"(cellular response to chloroquine)|interpro:IPR000157(Toll-Interleukin receptor)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR027181|interpro:IPR035897|interpro:IPR041283|mint:Q9EQU3|rcsb pdb:3WPF|rcsb pdb:3WPG|rcsb pdb:3WPH|rcsb pdb:3WPI|go:"GO:0032725"(positive regulation of granulocyte macrophage colony-stimulating factor production)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032741"(positive regulation of interleukin-18 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0034122"(negative regulation of toll-like receptor signaling pathway)|go:"GO:0034123"(positive regulation of toll-like receptor signaling pathway)|go:"GO:0034162"(toll-like receptor 9 signaling pathway)|go:"GO:0034163"(regulation of toll-like receptor 9 signaling pathway)|go:"GO:0034165"(positive regulation of toll-like receptor 9 signaling pathway)|go:"GO:0035197"(siRNA binding)|go:"GO:0036019"(endolysosome)|go:"GO:0038187"(pattern recognition receptor activity)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0032722"(positive regulation of chemokine production)	rgd:621725|refseq:NP_077327.1|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0000974"(Prp19 complex)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0001822"(kidney development)|go:"GO:0001916"(positive regulation of T cell mediated cytotoxicity)|go:"GO:0001917"(photoreceptor inner segment)|go:"GO:0003723"(RNA binding)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005770"(late endosome)|go:"GO:0005776"(autophagosome)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005882"(intermediate filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0006397"(mRNA processing)|go:"GO:0006457"(protein folding)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0007519"(skeletal muscle tissue development)|go:"GO:0007568"(aging)|go:"GO:0007608"(sensory perception of smell)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008088"(axo-dendritic transport)|go:"GO:0008380"(RNA splicing)|go:"GO:0009408"(response to heat)|go:"GO:0009986"(cell surface)|go:"GO:0010045"(response to nickel cation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010667"(negative regulation of cardiac muscle cell apoptotic process)|go:"GO:0014069"(postsynaptic density)|go:"GO:0014823"(response to activity)|go:"GO:0016191"(synaptic vesicle uncoating)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0019899"(enzyme binding)|go:"GO:0021549"(cerebellum development)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030900"(forebrain development)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031686"(A1 adenosine receptor binding)|go:"GO:0032279"(asymmetric synapse)|go:"GO:0032355"(response to estradiol)|go:"GO:0032570"(response to progesterone)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034605"(cellular response to heat)|go:"GO:0034620"(cellular response to unfolded protein)|go:"GO:0042026"(protein refolding)|go:"GO:0042277"(peptide binding)|go:"GO:0042470"(melanosome)|go:"GO:0042493"|go:"GO:0042594"(response to starvation)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043085"(positive regulation of catalytic activity)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043204"(perikaryon)|go:"GO:0043531"(ADP binding)|go:"GO:0043624"|go:"GO:0044183"(protein folding chaperone)|go:"GO:0044309"(neuron spine)|go:"GO:0044743"(protein transmembrane import into intracellular organelle)|go:"GO:0044788"(modulation by host of viral process)|go:"GO:0044829"(positive regulation by host of viral genome replication)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0045862"(positive regulation of proteolysis)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046034"(ATP metabolic process)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048026"(positive regulation of mRNA splicing, via spliceosome)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051787"(misfolded protein binding)|go:"GO:0055131"(C3HC4-type RING finger domain binding)|go:"GO:0061077"(chaperone-mediated protein folding)|go:"GO:0061635"(regulation of protein complex stability)|go:"GO:0061684"(chaperone-mediated autophagy)|go:"GO:0061738"(late endosomal microautophagy)|go:"GO:0061740"(protein targeting to lysosome involved in chaperone-mediated autophagy)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0072318"(clathrin coat disassembly)|go:"GO:0097214"(positive regulation of lysosomal membrane permeability)|go:"GO:0044849"(estrous cycle)|go:"GO:0098684"(photoreceptor ribbon synapse)|go:"GO:0098690"(glycinergic synapse)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098880"(maintenance of postsynaptic specialization structure)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099175"(regulation of postsynapse organization)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099634"(postsynaptic specialization membrane)|go:"GO:0101031"(chaperone complex)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1902904"(negative regulation of supramolecular fiber organization)|go:"GO:1903206"(negative regulation of hydrogen peroxide-induced cell death)|go:"GO:1904592"(positive regulation of protein refolding)|go:"GO:1904593"(prostaglandin binding)|go:"GO:1904764"(chaperone-mediated autophagy translocation complex disassembly)|go:"GO:1990124"(messenger ribonucleoprotein complex)|go:"GO:1990832"(slow axonal transport)|go:"GO:1990833"(clathrin-uncoating ATPase activity)|go:"GO:1990834"(response to odorant)|go:"GO:1990836"(lysosomal matrix)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR013126(Heat shock protein 70)|interpro:IPR018181|interpro:IPR029047|interpro:IPR029048|interpro:IPR043129|rcsb pdb:1CKR|rcsb pdb:1Q2G|rcsb pdb:1UD0|rcsb pdb:2V7Z|rcsb pdb:7HSC|mint:P63018|dip:DIP-33262N	-	-	-	figure legend:sf1b|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat-fibroblast)|taxid:10116(Rattus norvegicus)	-	2014/11/18	2014/11/18	rogid:3XKXj7PkEGE5qOchJfjMHFREkT010090	rogid:WDnUczLfoe3ODQbiEITN3DfQnFA10116	intact-crc:C88D7A0095F1C09B|rigid:0+mGgaCkpwPWzk6WvbzxFSAVf9s	false	calmodulin binding peptide plus protein a tag:c-c	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9EQU3	uniprotkb:O35824	intact:EBI-9979528|ensembl:ENSMUSP00000082207|uniprotkb:F8VPN5|uniprotkb:Q4L0K3|uniprotkb:Q4L0K4|uniprotkb:Q99MF2|uniprotkb:Q99MQ8	intact:EBI-1187217	psi-mi:tlr9_mouse(display_long)|uniprotkb:Tlr9(gene name)|psi-mi:Tlr9(display_short)	psi-mi:dnja2_rat(display_long)|uniprotkb:RDJ2(gene name synonym)|uniprotkb:Dnaja2(gene name)|psi-mi:Dnaja2(display_short)	psi-mi:"MI:0676"(tandem affinity purification)	Shintani et al. (2014)	imex:IM-23524|pubmed:24610369	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-9979662|imex:IM-23524-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000045322(gene)|ensembl:ENSMUST00000062241(transcript)|go:"GO:0001774"(microglial cell activation)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0002224"(toll-like receptor signaling pathway)|go:"GO:0002237"(response to molecule of bacterial origin)|go:"GO:0002639"(positive regulation of immunoglobulin production)|go:"GO:0002730"(regulation of dendritic cell cytokine production)|go:"GO:0002755"(MyD88-dependent toll-like receptor signaling pathway)|go:"GO:0005149"(interleukin-1 receptor binding)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|refseq:NP_112455.2|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0045087"(innate immune response)|go:"GO:0045322"(unmethylated CpG binding)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0045577"(regulation of B cell differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0050864"(regulation of B cell activation)|go:"GO:0050871"(positive regulation of B cell activation)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051607"(defense response to virus)|go:"GO:0051770"(positive regulation of nitric-oxide synthase biosynthetic process)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071248"(cellular response to metal ion)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:0005886"(plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0007252"(I-kappaB phosphorylation)|go:"GO:0008584"(male gonad development)|go:"GO:0009615"(response to virus)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030277"(maintenance of gastrointestinal epithelium)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0032009"(early phagosome)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032717"(negative regulation of interleukin-8 production)|go:"GO:0005789"(endoplasmic reticulum membrane)|rcsb pdb:4QDH|rcsb pdb:5ZLN|reactome:R-MMU-109704|reactome:R-MMU-1679131|reactome:R-MMU-168138|go:"GO:1901895"(negative regulation of ATPase-coupled calcium transmembrane transporter activity)|go:"GO:1902350"(cellular response to chloroquine)|interpro:IPR000157(Toll-Interleukin receptor)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR027181|interpro:IPR035897|interpro:IPR041283|mint:Q9EQU3|rcsb pdb:3WPF|rcsb pdb:3WPG|rcsb pdb:3WPH|rcsb pdb:3WPI|go:"GO:0032725"(positive regulation of granulocyte macrophage colony-stimulating factor production)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032741"(positive regulation of interleukin-18 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0034122"(negative regulation of toll-like receptor signaling pathway)|go:"GO:0034123"(positive regulation of toll-like receptor signaling pathway)|go:"GO:0034162"(toll-like receptor 9 signaling pathway)|go:"GO:0034163"(regulation of toll-like receptor 9 signaling pathway)|go:"GO:0034165"(positive regulation of toll-like receptor 9 signaling pathway)|go:"GO:0035197"(siRNA binding)|go:"GO:0036019"(endolysosome)|go:"GO:0038187"(pattern recognition receptor activity)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0032722"(positive regulation of chemokine production)	interpro:IPR001305(Heat shock protein DnaJ, cysteine-rich region)|rgd:71001|interpro:IPR012724(Chaperone DnaJ)|interpro:IPR002939(Chaperone DnaJ, C-terminal)|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR018253|interpro:IPR008971(HSP40/DnaJ peptide-binding)|go:"GO:0001671"(ATPase activator activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0009408"(response to heat)|go:"GO:0016020"(membrane)|go:"GO:0018885"(carbon tetrachloride metabolic process)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0042026"(protein refolding)|go:"GO:0046872"(metal ion binding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051087"(chaperone binding)|reactome:R-RNO-3371497|mint:O35824|interpro:IPR036410|interpro:IPR036869|interpro:IPR044713	-	-	-	figure legend:sf1b|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat-fibroblast)|taxid:10116(Rattus norvegicus)	-	2014/11/18	2014/11/18	rogid:3XKXj7PkEGE5qOchJfjMHFREkT010090	rogid:msgM7nFOH7krpYMCrW4lzOOcAmA10116	intact-crc:C88D7A0095F1C09B|rigid:0+mGgaCkpwPWzk6WvbzxFSAVf9s	false	calmodulin binding peptide plus protein a tag:c-c	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9EQU3	uniprotkb:P15999	intact:EBI-9979528|ensembl:ENSMUSP00000082207|uniprotkb:F8VPN5|uniprotkb:Q4L0K3|uniprotkb:Q4L0K4|uniprotkb:Q99MF2|uniprotkb:Q99MQ8	intact:EBI-916646|uniprotkb:Q6P753	psi-mi:tlr9_mouse(display_long)|uniprotkb:Tlr9(gene name)|psi-mi:Tlr9(display_short)	psi-mi:atpa_rat(display_long)|uniprotkb:Atp5f1a(gene name)|psi-mi:Atp5f1a(display_short)|uniprotkb:ATP synthase F1 subunit alpha(gene name synonym)|uniprotkb:Atp5a1(gene name synonym)	psi-mi:"MI:0676"(tandem affinity purification)	Shintani et al. (2014)	imex:IM-23524|pubmed:24610369	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-9979662|imex:IM-23524-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000045322(gene)|ensembl:ENSMUST00000062241(transcript)|go:"GO:0001774"(microglial cell activation)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0002224"(toll-like receptor signaling pathway)|go:"GO:0002237"(response to molecule of bacterial origin)|go:"GO:0002639"(positive regulation of immunoglobulin production)|go:"GO:0002730"(regulation of dendritic cell cytokine production)|go:"GO:0002755"(MyD88-dependent toll-like receptor signaling pathway)|go:"GO:0005149"(interleukin-1 receptor binding)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|refseq:NP_112455.2|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0045087"(innate immune response)|go:"GO:0045322"(unmethylated CpG binding)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0045577"(regulation of B cell differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0050864"(regulation of B cell activation)|go:"GO:0050871"(positive regulation of B cell activation)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051607"(defense response to virus)|go:"GO:0051770"(positive regulation of nitric-oxide synthase biosynthetic process)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071248"(cellular response to metal ion)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:0005886"(plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0007252"(I-kappaB phosphorylation)|go:"GO:0008584"(male gonad development)|go:"GO:0009615"(response to virus)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030277"(maintenance of gastrointestinal epithelium)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0032009"(early phagosome)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032717"(negative regulation of interleukin-8 production)|go:"GO:0005789"(endoplasmic reticulum membrane)|rcsb pdb:4QDH|rcsb pdb:5ZLN|reactome:R-MMU-109704|reactome:R-MMU-1679131|reactome:R-MMU-168138|go:"GO:1901895"(negative regulation of ATPase-coupled calcium transmembrane transporter activity)|go:"GO:1902350"(cellular response to chloroquine)|interpro:IPR000157(Toll-Interleukin receptor)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR027181|interpro:IPR035897|interpro:IPR041283|mint:Q9EQU3|rcsb pdb:3WPF|rcsb pdb:3WPG|rcsb pdb:3WPH|rcsb pdb:3WPI|go:"GO:0032725"(positive regulation of granulocyte macrophage colony-stimulating factor production)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032741"(positive regulation of interleukin-18 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0034122"(negative regulation of toll-like receptor signaling pathway)|go:"GO:0034123"(positive regulation of toll-like receptor signaling pathway)|go:"GO:0034162"(toll-like receptor 9 signaling pathway)|go:"GO:0034163"(regulation of toll-like receptor 9 signaling pathway)|go:"GO:0034165"(positive regulation of toll-like receptor 9 signaling pathway)|go:"GO:0035197"(siRNA binding)|go:"GO:0036019"(endolysosome)|go:"GO:0038187"(pattern recognition receptor activity)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0032722"(positive regulation of chemokine production)	rgd:619993|refseq:NP_075581.1|interpro:IPR020003|interpro:IPR005294(ATPase, F1 complex, alpha subunit)|interpro:IPR023366|interpro:IPR000793(ATPase, F1/V1/A1 complex, alpha/beta subunit, C-terminal)|interpro:IPR004100(ATPase, F1/V1/A1 complex, alpha/beta subunit, N-terminal)|interpro:IPR000194(ATPase, F1/V1/A1 complex, alpha/beta subunit, nucleotide-binding)|interpro:IPR033732|interpro:IPR027417|mint:P15999|interpro:IPR038376|interpro:IPR036121|go:"GO:0000275"("mitochondrial proton-transporting ATP synthase complex, catalytic sector F(1)")|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0002020"(protease binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005753"(mitochondrial proton-transporting ATP synthase complex)|go:"GO:0005754"(mitochondrial proton-transporting ATP synthase, catalytic core)|go:"GO:0005886"(plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0006754"(ATP biosynthetic process)|go:"GO:0006915"(apoptotic process)|go:"GO:0007568"(aging)|go:"GO:0009986"(cell surface)|go:"GO:0014850"(response to muscle activity)|go:"GO:0015986"(ATP synthesis coupled proton transport)|go:"GO:0016020"(membrane)|go:"GO:0042288"(MHC class I protein binding)|go:"GO:0042776"(mitochondrial ATP synthesis coupled proton transport)|go:"GO:0043531"(ADP binding)|go:"GO:0043532"(angiostatin binding)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0045121"(membrane raft)|go:"GO:0045259"(proton-transporting ATP synthase complex)|go:"GO:0045261"("proton-transporting ATP synthase complex, catalytic core F(1)")|go:"GO:0045471"(response to ethanol)|go:"GO:0046034"(ATP metabolic process)|go:"GO:0046933"(proton-transporting ATP synthase activity, rotational mechanism)|go:"GO:0071549"(cellular response to dexamethasone stimulus)|go:"GO:0071732"(cellular response to nitric oxide)|rcsb pdb:1MAB|rcsb pdb:2F43	-	-	-	figure legend:sf1b|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat-fibroblast)|taxid:10116(Rattus norvegicus)	-	2014/11/18	2014/11/18	rogid:3XKXj7PkEGE5qOchJfjMHFREkT010090	rogid:Jkbhz0cHR3egHpKo/n1Ex4EbnUI10116	intact-crc:C88D7A0095F1C09B|rigid:0+mGgaCkpwPWzk6WvbzxFSAVf9s	false	calmodulin binding peptide plus protein a tag:c-c	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9EQU3	uniprotkb:P18418	intact:EBI-9979528|ensembl:ENSMUSP00000082207|uniprotkb:F8VPN5|uniprotkb:Q4L0K3|uniprotkb:Q4L0K4|uniprotkb:Q99MF2|uniprotkb:Q99MQ8	intact:EBI-916742|uniprotkb:P10452|ensembl:ENSRNOP00000004091	psi-mi:tlr9_mouse(display_long)|uniprotkb:Tlr9(gene name)|psi-mi:Tlr9(display_short)	psi-mi:calr_rat(display_long)|uniprotkb:CRP55(gene name synonym)|uniprotkb:Calregulin(gene name synonym)|uniprotkb:HACBP(gene name synonym)|uniprotkb:Endoplasmic reticulum resident protein 60(gene name synonym)|uniprotkb:CALBP(gene name synonym)|uniprotkb:Calcium-binding protein 3(gene name synonym)|uniprotkb:Calr(gene name)|psi-mi:Calr(display_short)	psi-mi:"MI:0676"(tandem affinity purification)	Shintani et al. (2014)	imex:IM-23524|pubmed:24610369	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-9979662|imex:IM-23524-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000045322(gene)|ensembl:ENSMUST00000062241(transcript)|go:"GO:0001774"(microglial cell activation)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0002224"(toll-like receptor signaling pathway)|go:"GO:0002237"(response to molecule of bacterial origin)|go:"GO:0002639"(positive regulation of immunoglobulin production)|go:"GO:0002730"(regulation of dendritic cell cytokine production)|go:"GO:0002755"(MyD88-dependent toll-like receptor signaling pathway)|go:"GO:0005149"(interleukin-1 receptor binding)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|refseq:NP_112455.2|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0045087"(innate immune response)|go:"GO:0045322"(unmethylated CpG binding)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0045577"(regulation of B cell differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0050864"(regulation of B cell activation)|go:"GO:0050871"(positive regulation of B cell activation)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051607"(defense response to virus)|go:"GO:0051770"(positive regulation of nitric-oxide synthase biosynthetic process)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071248"(cellular response to metal ion)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:0005886"(plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0007252"(I-kappaB phosphorylation)|go:"GO:0008584"(male gonad development)|go:"GO:0009615"(response to virus)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030277"(maintenance of gastrointestinal epithelium)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0032009"(early phagosome)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032717"(negative regulation of interleukin-8 production)|go:"GO:0005789"(endoplasmic reticulum membrane)|rcsb pdb:4QDH|rcsb pdb:5ZLN|reactome:R-MMU-109704|reactome:R-MMU-1679131|reactome:R-MMU-168138|go:"GO:1901895"(negative regulation of ATPase-coupled calcium transmembrane transporter activity)|go:"GO:1902350"(cellular response to chloroquine)|interpro:IPR000157(Toll-Interleukin receptor)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR027181|interpro:IPR035897|interpro:IPR041283|mint:Q9EQU3|rcsb pdb:3WPF|rcsb pdb:3WPG|rcsb pdb:3WPH|rcsb pdb:3WPI|go:"GO:0032725"(positive regulation of granulocyte macrophage colony-stimulating factor production)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032741"(positive regulation of interleukin-18 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0034122"(negative regulation of toll-like receptor signaling pathway)|go:"GO:0034123"(positive regulation of toll-like receptor signaling pathway)|go:"GO:0034162"(toll-like receptor 9 signaling pathway)|go:"GO:0034163"(regulation of toll-like receptor 9 signaling pathway)|go:"GO:0034165"(positive regulation of toll-like receptor 9 signaling pathway)|go:"GO:0035197"(siRNA binding)|go:"GO:0036019"(endolysosome)|go:"GO:0038187"(pattern recognition receptor activity)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0032722"(positive regulation of chemokine production)	rgd:620288|refseq:NP_071794.1|ensembl:ENSRNOG00000003029(gene)|ensembl:ENSRNOT00000004091(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0002502"(peptide antigen assembly with MHC class I protein complex)|go:"GO:0003729"(mRNA binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005506"(iron ion binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0006457"(protein folding)|go:"GO:0006611"(protein export from nucleus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010033"(response to organic substance)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016020"(membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0030866"(cortical actin cytoskeleton organization)|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032355"(response to estradiol)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033018"(sarcoplasmic reticulum lumen)|go:"GO:0033144"(negative regulation of intracellular steroid hormone receptor signaling pathway)|go:"GO:0033574"(response to testosterone)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0040020"(regulation of meiotic nuclear division)|go:"GO:0042277"(peptide binding)|go:"GO:0042493"|go:"GO:0042562"(hormone binding)|go:"GO:0042824"(MHC class I peptide loading complex)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044322"(endoplasmic reticulum quality control compartment)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045787"(positive regulation of cell cycle)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048387"(negative regulation of retinoic acid receptor signaling pathway)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050681"(androgen receptor binding)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0060473"(cortical granule)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0071285"(cellular response to lithium ion)|go:"GO:0071310"(cellular response to organic substance)|go:"GO:0090398"(cellular senescence)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1901164"(negative regulation of trophoblast cell migration)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:2000510"(positive regulation of dendritic cell chemotaxis)|interpro:IPR001580(Calreticulin/calnexin)|interpro:IPR009033(Calreticulin/calnexin, P)|interpro:IPR009169(Calreticulin)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR018124|mint:P18418|rcsb pdb:1HHN|rcsb pdb:1K91|rcsb pdb:1K9C|reactome:R-RNO-1236974|reactome:R-RNO-3000480|reactome:R-RNO-901042|reactome:R-RNO-983170	-	-	-	figure legend:sf1b|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat-fibroblast)|taxid:10116(Rattus norvegicus)	-	2014/11/18	2014/11/18	rogid:3XKXj7PkEGE5qOchJfjMHFREkT010090	rogid:mFrLbrHGBN1Bxc+erHTyfw1NwMw10116	intact-crc:C88D7A0095F1C09B|rigid:0+mGgaCkpwPWzk6WvbzxFSAVf9s	false	calmodulin binding peptide plus protein a tag:c-c	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9EQU3	uniprotkb:Q63429	intact:EBI-9979528|ensembl:ENSMUSP00000082207|uniprotkb:F8VPN5|uniprotkb:Q4L0K3|uniprotkb:Q4L0K4|uniprotkb:Q99MF2|uniprotkb:Q99MQ8	intact:EBI-9979469|uniprotkb:Q3ZBA1	psi-mi:tlr9_mouse(display_long)|uniprotkb:Tlr9(gene name)|psi-mi:Tlr9(display_short)	psi-mi:ubc_rat(display_long)|uniprotkb:Ubc(gene name)|psi-mi:Ubc(display_short)	psi-mi:"MI:0676"(tandem affinity purification)	Shintani et al. (2014)	imex:IM-23524|pubmed:24610369	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-9979662|imex:IM-23524-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000045322(gene)|ensembl:ENSMUST00000062241(transcript)|go:"GO:0001774"(microglial cell activation)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0002224"(toll-like receptor signaling pathway)|go:"GO:0002237"(response to molecule of bacterial origin)|go:"GO:0002639"(positive regulation of immunoglobulin production)|go:"GO:0002730"(regulation of dendritic cell cytokine production)|go:"GO:0002755"(MyD88-dependent toll-like receptor signaling pathway)|go:"GO:0005149"(interleukin-1 receptor binding)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|refseq:NP_112455.2|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0045087"(innate immune response)|go:"GO:0045322"(unmethylated CpG binding)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0045577"(regulation of B cell differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0050864"(regulation of B cell activation)|go:"GO:0050871"(positive regulation of B cell activation)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051607"(defense response to virus)|go:"GO:0051770"(positive regulation of nitric-oxide synthase biosynthetic process)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071248"(cellular response to metal ion)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:0005886"(plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0007252"(I-kappaB phosphorylation)|go:"GO:0008584"(male gonad development)|go:"GO:0009615"(response to virus)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030277"(maintenance of gastrointestinal epithelium)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0032009"(early phagosome)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032717"(negative regulation of interleukin-8 production)|go:"GO:0005789"(endoplasmic reticulum membrane)|rcsb pdb:4QDH|rcsb pdb:5ZLN|reactome:R-MMU-109704|reactome:R-MMU-1679131|reactome:R-MMU-168138|go:"GO:1901895"(negative regulation of ATPase-coupled calcium transmembrane transporter activity)|go:"GO:1902350"(cellular response to chloroquine)|interpro:IPR000157(Toll-Interleukin receptor)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR027181|interpro:IPR035897|interpro:IPR041283|mint:Q9EQU3|rcsb pdb:3WPF|rcsb pdb:3WPG|rcsb pdb:3WPH|rcsb pdb:3WPI|go:"GO:0032725"(positive regulation of granulocyte macrophage colony-stimulating factor production)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032741"(positive regulation of interleukin-18 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0034122"(negative regulation of toll-like receptor signaling pathway)|go:"GO:0034123"(positive regulation of toll-like receptor signaling pathway)|go:"GO:0034162"(toll-like receptor 9 signaling pathway)|go:"GO:0034163"(regulation of toll-like receptor 9 signaling pathway)|go:"GO:0034165"(positive regulation of toll-like receptor 9 signaling pathway)|go:"GO:0035197"(siRNA binding)|go:"GO:0036019"(endolysosome)|go:"GO:0038187"(pattern recognition receptor activity)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0032722"(positive regulation of chemokine production)	reactome:R-RNO-168638|reactome:R-RNO-174048|reactome:R-RNO-174084|reactome:R-RNO-174154|reactome:R-RNO-174178|reactome:R-RNO-174184|reactome:R-RNO-179409|reactome:R-RNO-182971|reactome:R-RNO-187577|reactome:R-RNO-195253|reactome:R-RNO-201681|reactome:R-RNO-205043|reactome:R-RNO-209543|reactome:R-RNO-209560|reactome:R-RNO-2122948|reactome:R-RNO-2173788|reactome:R-RNO-2173791|reactome:R-RNO-2173795|reactome:R-RNO-2173796|reactome:R-RNO-2467813|reactome:R-RNO-1358803|go:"GO:0002020"(protease binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019941"(modification-dependent protein catabolic process)|go:"GO:0031386"(protein tag)|go:"GO:0031625"(ubiquitin protein ligase binding)|rcsb pdb:5L9U|reactome:R-RNO-110312|reactome:R-RNO-110314|reactome:R-RNO-110320|reactome:R-RNO-1169091|reactome:R-RNO-1234176|reactome:R-RNO-1253288|reactome:R-RNO-1295596|reactome:R-RNO-5610785|reactome:R-RNO-5632684|reactome:R-RNO-5654726|reactome:R-RNO-532668|reactome:R-RNO-2559580|reactome:R-RNO-2559582|reactome:R-RNO-2559585|reactome:R-RNO-2565942|reactome:R-RNO-2672351|reactome:R-RNO-3134975|reactome:R-RNO-349425|reactome:R-RNO-3769402|reactome:R-RNO-382556|reactome:R-RNO-445989|reactome:R-RNO-450302|reactome:R-RNO-450321|reactome:R-RNO-450408|reactome:R-RNO-5357905|reactome:R-RNO-5357956|reactome:R-RNO-4608870|reactome:R-RNO-4641257|reactome:R-RNO-4641258|reactome:R-RNO-4641263|reactome:R-RNO-5358346|reactome:R-RNO-5607761|reactome:R-RNO-5610780|reactome:R-RNO-9664873|reactome:R-RNO-9705462|reactome:R-RNO-9706369|reactome:R-RNO-975163|reactome:R-RNO-983168|reactome:R-RNO-9648002|reactome:R-RNO-5654732|reactome:R-RNO-5654727|reactome:R-RNO-5654733|reactome:R-RNO-5655862|reactome:R-RNO-5656121|reactome:R-RNO-5656169|reactome:R-RNO-5658442|reactome:R-RNO-5668541|reactome:R-RNO-5675221|reactome:R-RNO-5675482|reactome:R-RNO-5676590|reactome:R-RNO-5685942|reactome:R-RNO-5687128|reactome:R-RNO-5689603|reactome:R-RNO-5689877|reactome:R-RNO-5689880|reactome:R-RNO-5689896|reactome:R-RNO-5689901|reactome:R-RNO-5693565|reactome:R-RNO-5696394|reactome:R-RNO-5696395|reactome:R-RNO-5696397|reactome:R-RNO-5696400|reactome:R-RNO-6781823|reactome:R-RNO-6782135|reactome:R-RNO-6782210|reactome:R-RNO-6783310|reactome:R-RNO-6804756|reactome:R-RNO-6804757|reactome:R-RNO-6804760|reactome:R-RNO-6807004|reactome:R-RNO-68827|reactome:R-RNO-68949|reactome:R-RNO-69017|reactome:R-RNO-69231|reactome:R-RNO-69481|reactome:R-RNO-69541|reactome:R-RNO-69601|reactome:R-RNO-75815|reactome:R-RNO-8849469|reactome:R-RNO-8852276|reactome:R-RNO-8854050|reactome:R-RNO-8856825|reactome:R-RNO-8863795|reactome:R-RNO-8866652|reactome:R-RNO-8856828|reactome:R-RNO-8866654|reactome:R-RNO-8932339|reactome:R-RNO-8939236|reactome:R-RNO-8941858|reactome:R-RNO-8948747|reactome:R-RNO-8948751|reactome:R-RNO-8951664|reactome:R-RNO-901032|reactome:R-RNO-9013507|reactome:R-RNO-9020702|reactome:R-RNO-9033241|reactome:R-RNO-912631|reactome:R-RNO-917729|reactome:R-RNO-917937|reactome:R-RNO-937042|reactome:R-RNO-937072|reactome:R-RNO-9645460|reactome:R-RNO-9646399|refseq:NP_059010.1|interpro:IPR019956|interpro:IPR000626(Ubiquitin)|interpro:IPR029071|interpro:IPR019954|rgd:621244|mint:Q63429	-	-	-	figure legend:sf1b|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat-fibroblast)|taxid:10116(Rattus norvegicus)	-	2014/11/18	2014/11/18	rogid:3XKXj7PkEGE5qOchJfjMHFREkT010090	rogid:9QQbp2rY1QHl68DhN4zYQMPXuZ410116	intact-crc:C88D7A0095F1C09B|rigid:0+mGgaCkpwPWzk6WvbzxFSAVf9s	false	calmodulin binding peptide plus protein a tag:c-c	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9EQU3	uniprotkb:P06761	intact:EBI-9979528|ensembl:ENSMUSP00000082207|uniprotkb:F8VPN5|uniprotkb:Q4L0K3|uniprotkb:Q4L0K4|uniprotkb:Q99MF2|uniprotkb:Q99MQ8	intact:EBI-916036|ensembl:ENSRNOP00000025064	psi-mi:tlr9_mouse(display_long)|uniprotkb:Tlr9(gene name)|psi-mi:Tlr9(display_short)	psi-mi:bip_rat(display_long)|uniprotkb:Hspa5(gene name)|psi-mi:Hspa5(display_short)|uniprotkb:Grp78(gene name synonym)|uniprotkb:Immunoglobulin heavy chain-binding protein(gene name synonym)|uniprotkb:Steroidogenesis-activator polypeptide(gene name synonym)|uniprotkb:78 kDa glucose-regulated protein(gene name synonym)|uniprotkb:Binding-immunoglobulin protein(gene name synonym)|uniprotkb:Heat shock protein 70 family protein 5(gene name synonym)|uniprotkb:Heat shock protein family A member 5(gene name synonym)	psi-mi:"MI:0676"(tandem affinity purification)	Shintani et al. (2014)	imex:IM-23524|pubmed:24610369	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-9979662|imex:IM-23524-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000045322(gene)|ensembl:ENSMUST00000062241(transcript)|go:"GO:0001774"(microglial cell activation)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0002224"(toll-like receptor signaling pathway)|go:"GO:0002237"(response to molecule of bacterial origin)|go:"GO:0002639"(positive regulation of immunoglobulin production)|go:"GO:0002730"(regulation of dendritic cell cytokine production)|go:"GO:0002755"(MyD88-dependent toll-like receptor signaling pathway)|go:"GO:0005149"(interleukin-1 receptor binding)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|refseq:NP_112455.2|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0045087"(innate immune response)|go:"GO:0045322"(unmethylated CpG binding)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0045577"(regulation of B cell differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0050864"(regulation of B cell activation)|go:"GO:0050871"(positive regulation of B cell activation)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051607"(defense response to virus)|go:"GO:0051770"(positive regulation of nitric-oxide synthase biosynthetic process)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071248"(cellular response to metal ion)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:0005886"(plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0007252"(I-kappaB phosphorylation)|go:"GO:0008584"(male gonad development)|go:"GO:0009615"(response to virus)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030277"(maintenance of gastrointestinal epithelium)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0032009"(early phagosome)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032717"(negative regulation of interleukin-8 production)|go:"GO:0005789"(endoplasmic reticulum membrane)|rcsb pdb:4QDH|rcsb pdb:5ZLN|reactome:R-MMU-109704|reactome:R-MMU-1679131|reactome:R-MMU-168138|go:"GO:1901895"(negative regulation of ATPase-coupled calcium transmembrane transporter activity)|go:"GO:1902350"(cellular response to chloroquine)|interpro:IPR000157(Toll-Interleukin receptor)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR027181|interpro:IPR035897|interpro:IPR041283|mint:Q9EQU3|rcsb pdb:3WPF|rcsb pdb:3WPG|rcsb pdb:3WPH|rcsb pdb:3WPI|go:"GO:0032725"(positive regulation of granulocyte macrophage colony-stimulating factor production)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032741"(positive regulation of interleukin-18 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0034122"(negative regulation of toll-like receptor signaling pathway)|go:"GO:0034123"(positive regulation of toll-like receptor signaling pathway)|go:"GO:0034162"(toll-like receptor 9 signaling pathway)|go:"GO:0034163"(regulation of toll-like receptor 9 signaling pathway)|go:"GO:0034165"(positive regulation of toll-like receptor 9 signaling pathway)|go:"GO:0035197"(siRNA binding)|go:"GO:0036019"(endolysosome)|go:"GO:0038187"(pattern recognition receptor activity)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0032722"(positive regulation of chemokine production)	rgd:2843|refseq:NP_037215.1|ensembl:ENSRNOG00000018294(gene)|ensembl:ENSRNOT00000025067(transcript)|go:"GO:0001554"(luteolysis)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006983"(ER overload response)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0009314"(response to radiation)|go:"GO:0009986"(cell surface)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0016020"(membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0021589"(cerebellum structural organization)|go:"GO:0021680"(cerebellar Purkinje cell layer development)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030496"(midbody)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031204"(posttranslational protein targeting to membrane, translocation)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034620"(cellular response to unfolded protein)|go:"GO:0034663"(endoplasmic reticulum chaperone complex)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035437"(maintenance of protein localization in endoplasmic reticulum)|go:"GO:0035690"|go:"GO:0036498"(IRE1-mediated unfolded protein response)|go:"GO:0042026"(protein refolding)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0042220"(response to cocaine)|go:"GO:0043022"(ribosome binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0051603"(proteolysis involved in cellular protein catabolic process)|go:"GO:0051787"(misfolded protein binding)|go:"GO:0071236"(cellular response to antibiotic)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0071287"(cellular response to manganese ion)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071353"(cellular response to interleukin-4)|go:"GO:0071480"(cellular response to gamma radiation)|go:"GO:0097501"(stress response to metal ion)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1901998"(toxin transport)|go:"GO:1903895"(negative regulation of IRE1-mediated unfolded protein response)|go:"GO:1904313"(response to methamphetamine hydrochloride)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|interpro:IPR013126(Heat shock protein 70)|interpro:IPR018181|interpro:IPR029047|interpro:IPR029048|interpro:IPR042050|interpro:IPR043129|mint:P06761|reactome:R-RNO-3371453|reactome:R-RNO-983170	-	-	-	figure legend:sf1b|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat-fibroblast)|taxid:10116(Rattus norvegicus)	-	2014/11/18	2014/11/18	rogid:3XKXj7PkEGE5qOchJfjMHFREkT010090	rogid:5HRXkoNHYJvBA2iejRqltGRdJDw10116	intact-crc:C88D7A0095F1C09B|rigid:0+mGgaCkpwPWzk6WvbzxFSAVf9s	false	calmodulin binding peptide plus protein a tag:c-c	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9EQU3	uniprotkb:P11507	intact:EBI-9979528|ensembl:ENSMUSP00000082207|uniprotkb:F8VPN5|uniprotkb:Q4L0K3|uniprotkb:Q4L0K4|uniprotkb:Q99MF2|uniprotkb:Q99MQ8	intact:EBI-916319|uniprotkb:P11508|ensembl:ENSRNOP00000024347	psi-mi:tlr9_mouse(display_long)|uniprotkb:Tlr9(gene name)|psi-mi:Tlr9(display_short)	psi-mi:at2a2_rat(display_long)|uniprotkb:Calcium pump 2(gene name synonym)|uniprotkb:Calcium-transporting ATPase sarcoplasmic reticulum type, slow twitch skeletal muscle isoform(gene name synonym)|uniprotkb:"Endoplasmic reticulum class 1/2 Ca(2+) ATPase"(gene name synonym)|uniprotkb:Atp2a2(gene name)|psi-mi:Atp2a2(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Shintani et al. (2014)	imex:IM-23524|pubmed:24610369	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-9980156|imex:IM-23524-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000045322(gene)|ensembl:ENSMUST00000062241(transcript)|go:"GO:0001774"(microglial cell activation)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0002224"(toll-like receptor signaling pathway)|go:"GO:0002237"(response to molecule of bacterial origin)|go:"GO:0002639"(positive regulation of immunoglobulin production)|go:"GO:0002730"(regulation of dendritic cell cytokine production)|go:"GO:0002755"(MyD88-dependent toll-like receptor signaling pathway)|go:"GO:0005149"(interleukin-1 receptor binding)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|refseq:NP_112455.2|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0045087"(innate immune response)|go:"GO:0045322"(unmethylated CpG binding)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0045577"(regulation of B cell differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0050864"(regulation of B cell activation)|go:"GO:0050871"(positive regulation of B cell activation)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051607"(defense response to virus)|go:"GO:0051770"(positive regulation of nitric-oxide synthase biosynthetic process)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071248"(cellular response to metal ion)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:0005886"(plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0007252"(I-kappaB phosphorylation)|go:"GO:0008584"(male gonad development)|go:"GO:0009615"(response to virus)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030277"(maintenance of gastrointestinal epithelium)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0032009"(early phagosome)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032717"(negative regulation of interleukin-8 production)|go:"GO:0005789"(endoplasmic reticulum membrane)|rcsb pdb:4QDH|rcsb pdb:5ZLN|reactome:R-MMU-109704|reactome:R-MMU-1679131|reactome:R-MMU-168138|go:"GO:1901895"(negative regulation of ATPase-coupled calcium transmembrane transporter activity)|go:"GO:1902350"(cellular response to chloroquine)|interpro:IPR000157(Toll-Interleukin receptor)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR027181|interpro:IPR035897|interpro:IPR041283|mint:Q9EQU3|rcsb pdb:3WPF|rcsb pdb:3WPG|rcsb pdb:3WPH|rcsb pdb:3WPI|go:"GO:0032725"(positive regulation of granulocyte macrophage colony-stimulating factor production)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032741"(positive regulation of interleukin-18 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0034122"(negative regulation of toll-like receptor signaling pathway)|go:"GO:0034123"(positive regulation of toll-like receptor signaling pathway)|go:"GO:0034162"(toll-like receptor 9 signaling pathway)|go:"GO:0034163"(regulation of toll-like receptor 9 signaling pathway)|go:"GO:0034165"(positive regulation of toll-like receptor 9 signaling pathway)|go:"GO:0035197"(siRNA binding)|go:"GO:0036019"(endolysosome)|go:"GO:0038187"(pattern recognition receptor activity)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0032722"(positive regulation of chemokine production)	ensembl:ENSRNOG00000001285(gene)|ensembl:ENSRNOT00000024347(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0002026"(regulation of the force of heart contraction)|go:"GO:0003009"(skeletal muscle contraction)|go:"GO:0005388"(P-type calcium transporter activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006937"(regulation of muscle contraction)|go:"GO:0006984"(ER-nucleus signaling pathway)|go:"GO:0006996"(organelle organization)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008553"(P-type proton-exporting transporter activity)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0012506"(vesicle membrane)|go:"GO:0014883"(transition between fast and slow fiber)|go:"GO:0120025"(plasma membrane bounded cell projection)|go:"GO:0140056"(organelle localization by membrane tethering)|go:"GO:1900121"(negative regulation of receptor binding)|go:"GO:1903233"(regulation of calcium ion-dependent exocytosis of neurotransmitter)|go:"GO:1903515"(calcium ion transport from cytosol to endoplasmic reticulum)|go:"GO:1990036"(calcium ion import into sarcoplasmic reticulum)|go:"GO:1990456"(mitochondrion-endoplasmic reticulum membrane tethering)|interpro:IPR001757(ATPase, P-type, K/Mg/Cd/Cu/Zn/Na/Ca/Na/H-transporter)|interpro:IPR004014(ATPase, P-type cation-transporter, N-terminal)|interpro:IPR005782(Calcium ATPase)|interpro:IPR006068(ATPase, P-type cation-transporter, C-terminal)|interpro:IPR008250(E1-E2 ATPase-associated region)|interpro:IPR018303|interpro:IPR023214|interpro:IPR023298|interpro:IPR023299|interpro:IPR036412|interpro:IPR044492|mint:P11507|reactome:R-RNO-418359|reactome:R-RNO-5578775|reactome:R-RNO-936837|go:"GO:0014898"(cardiac muscle hypertrophy in response to stress)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016240"(autophagosome membrane docking)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0019899"(enzyme binding)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031775"(lutropin-choriogonadotropic hormone receptor binding)|go:"GO:0032469"(endoplasmic reticulum calcium ion homeostasis)|go:"GO:0032470"(positive regulation of endoplasmic reticulum calcium ion concentration)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033017"(sarcoplasmic reticulum membrane)|go:"GO:0033292"(T-tubule organization)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0034605"(cellular response to heat)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044548"(S100 protein binding)|go:"GO:0045822"(negative regulation of heart contraction)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0055119"(relaxation of cardiac muscle)|go:"GO:0061831"(apical ectoplasmic specialization)|go:"GO:0070296"(sarcoplasmic reticulum calcium ion transport)|go:"GO:0070588"(calcium ion transmembrane transport)|go:"GO:0086036"(regulation of cardiac muscle cell membrane potential)|go:"GO:0086039"(P-type calcium transporter activity involved in regulation of cardiac muscle cell membrane potential)|go:"GO:0097470"(ribbon synapse)|go:"GO:0098909"(regulation of cardiac muscle cell action potential involved in regulation of contraction)|rgd:2174|refseq:NP_001103609.1|refseq:NP_001104293.1	-	-	-	figure legend:sf1a|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat-cardiac_myocytes)|taxid:10116(rat cardiac myocytes)	-	2014/11/18	2014/11/19	rogid:3XKXj7PkEGE5qOchJfjMHFREkT010090	rogid:Et/ot4KEtlnq8iuoVL0CySJICIo10116	intact-crc:FF359E42F30D7ACF|rigid:ccFBBjaz7Nk3/+xJTnDC+8CvEnk	false	calmodulin binding peptide plus protein a tag:c-c	-	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9EQU3	uniprotkb:Q6TUG0	intact:EBI-9979528|ensembl:ENSMUSP00000082207|uniprotkb:F8VPN5|uniprotkb:Q4L0K3|uniprotkb:Q4L0K4|uniprotkb:Q99MF2|uniprotkb:Q99MQ8	intact:EBI-919258|ensembl:ENSRNOP00000002462	psi-mi:tlr9_mouse(display_long)|uniprotkb:Tlr9(gene name)|psi-mi:Tlr9(display_short)	psi-mi:djb11_rat(display_long)|uniprotkb:Dnajb11(gene name)|psi-mi:Dnajb11(display_short)|uniprotkb:ER-associated Hsp40 co-chaperone(gene name synonym)|uniprotkb:ER-associated DNAJ(gene name synonym)|uniprotkb:Liver regeneration-related protein LRRGT00084(gene name synonym)|uniprotkb:Endoplasmic reticulum DNA J domain-containing protein 3(gene name synonym)	psi-mi:"MI:0676"(tandem affinity purification)	Shintani et al. (2014)	imex:IM-23524|pubmed:24610369	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-9979511|imex:IM-23524-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000045322(gene)|ensembl:ENSMUST00000062241(transcript)|go:"GO:0001774"(microglial cell activation)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0002224"(toll-like receptor signaling pathway)|go:"GO:0002237"(response to molecule of bacterial origin)|go:"GO:0002639"(positive regulation of immunoglobulin production)|go:"GO:0002730"(regulation of dendritic cell cytokine production)|go:"GO:0002755"(MyD88-dependent toll-like receptor signaling pathway)|go:"GO:0005149"(interleukin-1 receptor binding)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|refseq:NP_112455.2|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0045087"(innate immune response)|go:"GO:0045322"(unmethylated CpG binding)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0045577"(regulation of B cell differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0050864"(regulation of B cell activation)|go:"GO:0050871"(positive regulation of B cell activation)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051607"(defense response to virus)|go:"GO:0051770"(positive regulation of nitric-oxide synthase biosynthetic process)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071248"(cellular response to metal ion)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:0005886"(plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0007252"(I-kappaB phosphorylation)|go:"GO:0008584"(male gonad development)|go:"GO:0009615"(response to virus)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030277"(maintenance of gastrointestinal epithelium)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0032009"(early phagosome)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032717"(negative regulation of interleukin-8 production)|go:"GO:0005789"(endoplasmic reticulum membrane)|rcsb pdb:4QDH|rcsb pdb:5ZLN|reactome:R-MMU-109704|reactome:R-MMU-1679131|reactome:R-MMU-168138|go:"GO:1901895"(negative regulation of ATPase-coupled calcium transmembrane transporter activity)|go:"GO:1902350"(cellular response to chloroquine)|interpro:IPR000157(Toll-Interleukin receptor)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR027181|interpro:IPR035897|interpro:IPR041283|mint:Q9EQU3|rcsb pdb:3WPF|rcsb pdb:3WPG|rcsb pdb:3WPH|rcsb pdb:3WPI|go:"GO:0032725"(positive regulation of granulocyte macrophage colony-stimulating factor production)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032741"(positive regulation of interleukin-18 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0034122"(negative regulation of toll-like receptor signaling pathway)|go:"GO:0034123"(positive regulation of toll-like receptor signaling pathway)|go:"GO:0034162"(toll-like receptor 9 signaling pathway)|go:"GO:0034163"(regulation of toll-like receptor 9 signaling pathway)|go:"GO:0034165"(positive regulation of toll-like receptor 9 signaling pathway)|go:"GO:0035197"(siRNA binding)|go:"GO:0036019"(endolysosome)|go:"GO:0038187"(pattern recognition receptor activity)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0032722"(positive regulation of chemokine production)	rgd:1307373|refseq:NP_001015021.1|ensembl:ENSRNOG00000001803(gene)|ensembl:ENSRNOT00000002462(transcript)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0006457"(protein folding)|go:"GO:0016556"(mRNA modification)|go:"GO:0032781"(positive regulation of ATP-dependent activity)|go:"GO:0034663"(endoplasmic reticulum chaperone complex)|go:"GO:0050768"(negative regulation of neurogenesis)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051604"(protein maturation)|go:"GO:0051787"(misfolded protein binding)|go:"GO:0101031"(chaperone complex)|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR002939(Chaperone DnaJ, C-terminal)|interpro:IPR008971(HSP40/DnaJ peptide-binding)|interpro:IPR018253|interpro:IPR036869|mint:Q6TUG0	-	-	-	figure legend:sf1b f1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat-cardiac_myocytes)|taxid:10116(rat cardiac myocytes)	-	2014/11/18	2014/11/18	rogid:3XKXj7PkEGE5qOchJfjMHFREkT010090	rogid:NMsvYKrs7f8hoFUT68Xt5cEHnDU10116	intact-crc:70A3FF53549AB406|rigid:8b0W4ZmSLQHpG6EH8YyUNdlAlZE	false	calmodulin binding peptide plus protein a tag:c-c	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9EQU3	uniprotkb:P17702	intact:EBI-9979528|ensembl:ENSMUSP00000082207|uniprotkb:F8VPN5|uniprotkb:Q4L0K3|uniprotkb:Q4L0K4|uniprotkb:Q99MF2|uniprotkb:Q99MQ8	intact:EBI-931425	psi-mi:tlr9_mouse(display_long)|uniprotkb:Tlr9(gene name)|psi-mi:Tlr9(display_short)	psi-mi:rl28_rat(display_long)|uniprotkb:Rpl28(gene name)|psi-mi:Rpl28(display_short)	psi-mi:"MI:0676"(tandem affinity purification)	Shintani et al. (2014)	imex:IM-23524|pubmed:24610369	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-9979511|imex:IM-23524-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000045322(gene)|ensembl:ENSMUST00000062241(transcript)|go:"GO:0001774"(microglial cell activation)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0002224"(toll-like receptor signaling pathway)|go:"GO:0002237"(response to molecule of bacterial origin)|go:"GO:0002639"(positive regulation of immunoglobulin production)|go:"GO:0002730"(regulation of dendritic cell cytokine production)|go:"GO:0002755"(MyD88-dependent toll-like receptor signaling pathway)|go:"GO:0005149"(interleukin-1 receptor binding)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|refseq:NP_112455.2|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0045087"(innate immune response)|go:"GO:0045322"(unmethylated CpG binding)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0045577"(regulation of B cell differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0050864"(regulation of B cell activation)|go:"GO:0050871"(positive regulation of B cell activation)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051607"(defense response to virus)|go:"GO:0051770"(positive regulation of nitric-oxide synthase biosynthetic process)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071248"(cellular response to metal ion)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:0005886"(plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0007252"(I-kappaB phosphorylation)|go:"GO:0008584"(male gonad development)|go:"GO:0009615"(response to virus)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030277"(maintenance of gastrointestinal epithelium)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0032009"(early phagosome)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032717"(negative regulation of interleukin-8 production)|go:"GO:0005789"(endoplasmic reticulum membrane)|rcsb pdb:4QDH|rcsb pdb:5ZLN|reactome:R-MMU-109704|reactome:R-MMU-1679131|reactome:R-MMU-168138|go:"GO:1901895"(negative regulation of ATPase-coupled calcium transmembrane transporter activity)|go:"GO:1902350"(cellular response to chloroquine)|interpro:IPR000157(Toll-Interleukin receptor)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR027181|interpro:IPR035897|interpro:IPR041283|mint:Q9EQU3|rcsb pdb:3WPF|rcsb pdb:3WPG|rcsb pdb:3WPH|rcsb pdb:3WPI|go:"GO:0032725"(positive regulation of granulocyte macrophage colony-stimulating factor production)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032741"(positive regulation of interleukin-18 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0034122"(negative regulation of toll-like receptor signaling pathway)|go:"GO:0034123"(positive regulation of toll-like receptor signaling pathway)|go:"GO:0034162"(toll-like receptor 9 signaling pathway)|go:"GO:0034163"(regulation of toll-like receptor 9 signaling pathway)|go:"GO:0034165"(positive regulation of toll-like receptor 9 signaling pathway)|go:"GO:0035197"(siRNA binding)|go:"GO:0036019"(endolysosome)|go:"GO:0038187"(pattern recognition receptor activity)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0032722"(positive regulation of chemokine production)	interpro:IPR002672(Ribosomal protein L28e)|rgd:621193|interpro:IPR029004|mint:P17702|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0006412"(translation)|go:"GO:0022625"(cytosolic large ribosomal subunit)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0030425"(dendrite)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0044297"(cell body)	-	-	-	figure legend:sf1b f1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat-cardiac_myocytes)|taxid:10116(rat cardiac myocytes)	-	2014/11/18	2014/11/18	rogid:3XKXj7PkEGE5qOchJfjMHFREkT010090	rogid:jQoQgNJjRSQbeDX0xjv0ji4Y0LA10116	intact-crc:70A3FF53549AB406|rigid:8b0W4ZmSLQHpG6EH8YyUNdlAlZE	false	calmodulin binding peptide plus protein a tag:c-c	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9EQU3	uniprotkb:Q9Z142	intact:EBI-9979528|ensembl:ENSMUSP00000082207|uniprotkb:F8VPN5|uniprotkb:Q4L0K3|uniprotkb:Q4L0K4|uniprotkb:Q99MF2|uniprotkb:Q99MQ8	intact:EBI-9979483	psi-mi:tlr9_mouse(display_long)|uniprotkb:Tlr9(gene name)|psi-mi:Tlr9(display_short)	psi-mi:tmm33_rat(display_long)|uniprotkb:Tmem33(gene name)|psi-mi:Tmem33(display_short)|uniprotkb:Db83(gene name synonym)|uniprotkb:Protein DB83(gene name synonym)	psi-mi:"MI:0676"(tandem affinity purification)	Shintani et al. (2014)	imex:IM-23524|pubmed:24610369	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-9979511|imex:IM-23524-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000045322(gene)|ensembl:ENSMUST00000062241(transcript)|go:"GO:0001774"(microglial cell activation)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0002224"(toll-like receptor signaling pathway)|go:"GO:0002237"(response to molecule of bacterial origin)|go:"GO:0002639"(positive regulation of immunoglobulin production)|go:"GO:0002730"(regulation of dendritic cell cytokine production)|go:"GO:0002755"(MyD88-dependent toll-like receptor signaling pathway)|go:"GO:0005149"(interleukin-1 receptor binding)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|refseq:NP_112455.2|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0045087"(innate immune response)|go:"GO:0045322"(unmethylated CpG binding)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0045577"(regulation of B cell differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0050864"(regulation of B cell activation)|go:"GO:0050871"(positive regulation of B cell activation)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051607"(defense response to virus)|go:"GO:0051770"(positive regulation of nitric-oxide synthase biosynthetic process)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071248"(cellular response to metal ion)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:0005886"(plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0007252"(I-kappaB phosphorylation)|go:"GO:0008584"(male gonad development)|go:"GO:0009615"(response to virus)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030277"(maintenance of gastrointestinal epithelium)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0032009"(early phagosome)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032717"(negative regulation of interleukin-8 production)|go:"GO:0005789"(endoplasmic reticulum membrane)|rcsb pdb:4QDH|rcsb pdb:5ZLN|reactome:R-MMU-109704|reactome:R-MMU-1679131|reactome:R-MMU-168138|go:"GO:1901895"(negative regulation of ATPase-coupled calcium transmembrane transporter activity)|go:"GO:1902350"(cellular response to chloroquine)|interpro:IPR000157(Toll-Interleukin receptor)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR027181|interpro:IPR035897|interpro:IPR041283|mint:Q9EQU3|rcsb pdb:3WPF|rcsb pdb:3WPG|rcsb pdb:3WPH|rcsb pdb:3WPI|go:"GO:0032725"(positive regulation of granulocyte macrophage colony-stimulating factor production)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032741"(positive regulation of interleukin-18 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0034122"(negative regulation of toll-like receptor signaling pathway)|go:"GO:0034123"(positive regulation of toll-like receptor signaling pathway)|go:"GO:0034162"(toll-like receptor 9 signaling pathway)|go:"GO:0034163"(regulation of toll-like receptor 9 signaling pathway)|go:"GO:0034165"(positive regulation of toll-like receptor 9 signaling pathway)|go:"GO:0035197"(siRNA binding)|go:"GO:0036019"(endolysosome)|go:"GO:0038187"(pattern recognition receptor activity)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0032722"(positive regulation of chemokine production)	go:"GO:0005635"(nuclear envelope)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0042470"(melanosome)|go:"GO:0061024"(membrane organization)|go:"GO:0071786"(endoplasmic reticulum tubular network organization)|go:"GO:1903371"(regulation of endoplasmic reticulum tubular network organization)|go:"GO:1903896"(positive regulation of IRE1-mediated unfolded protein response)|go:"GO:1903899"(positive regulation of PERK-mediated unfolded protein response)|refseq:NP_067703.1|interpro:IPR005344(Protein of unknown function UPF0121)|rgd:708371|mint:Q9Z142	-	-	-	figure legend:sf1b f1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat-cardiac_myocytes)|taxid:10116(rat cardiac myocytes)	-	2014/11/18	2014/11/18	rogid:3XKXj7PkEGE5qOchJfjMHFREkT010090	rogid:PcG/OnnTN84P2xlZPzcI5j+QYRo10116	intact-crc:70A3FF53549AB406|rigid:8b0W4ZmSLQHpG6EH8YyUNdlAlZE	false	calmodulin binding peptide plus protein a tag:c-c	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9EQU3	uniprotkb:P35435	intact:EBI-9979528|ensembl:ENSMUSP00000082207|uniprotkb:F8VPN5|uniprotkb:Q4L0K3|uniprotkb:Q4L0K4|uniprotkb:Q99MF2|uniprotkb:Q99MQ8	intact:EBI-917355	psi-mi:tlr9_mouse(display_long)|uniprotkb:Tlr9(gene name)|psi-mi:Tlr9(display_short)	psi-mi:atpg_rat(display_long)|uniprotkb:Atp5f1c(gene name)|psi-mi:Atp5f1c(display_short)|uniprotkb:ATP synthase F1 subunit gamma(gene name synonym)|uniprotkb:Atp5c(gene name synonym)|uniprotkb:Atp5c1(gene name synonym)|uniprotkb:F-ATPase gamma subunit(gene name synonym)	psi-mi:"MI:0676"(tandem affinity purification)	Shintani et al. (2014)	imex:IM-23524|pubmed:24610369	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-9979511|imex:IM-23524-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000045322(gene)|ensembl:ENSMUST00000062241(transcript)|go:"GO:0001774"(microglial cell activation)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0002224"(toll-like receptor signaling pathway)|go:"GO:0002237"(response to molecule of bacterial origin)|go:"GO:0002639"(positive regulation of immunoglobulin production)|go:"GO:0002730"(regulation of dendritic cell cytokine production)|go:"GO:0002755"(MyD88-dependent toll-like receptor signaling pathway)|go:"GO:0005149"(interleukin-1 receptor binding)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|refseq:NP_112455.2|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0045087"(innate immune response)|go:"GO:0045322"(unmethylated CpG binding)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0045577"(regulation of B cell differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0050864"(regulation of B cell activation)|go:"GO:0050871"(positive regulation of B cell activation)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051607"(defense response to virus)|go:"GO:0051770"(positive regulation of nitric-oxide synthase biosynthetic process)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071248"(cellular response to metal ion)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:0005886"(plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0007252"(I-kappaB phosphorylation)|go:"GO:0008584"(male gonad development)|go:"GO:0009615"(response to virus)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030277"(maintenance of gastrointestinal epithelium)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0032009"(early phagosome)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032717"(negative regulation of interleukin-8 production)|go:"GO:0005789"(endoplasmic reticulum membrane)|rcsb pdb:4QDH|rcsb pdb:5ZLN|reactome:R-MMU-109704|reactome:R-MMU-1679131|reactome:R-MMU-168138|go:"GO:1901895"(negative regulation of ATPase-coupled calcium transmembrane transporter activity)|go:"GO:1902350"(cellular response to chloroquine)|interpro:IPR000157(Toll-Interleukin receptor)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR027181|interpro:IPR035897|interpro:IPR041283|mint:Q9EQU3|rcsb pdb:3WPF|rcsb pdb:3WPG|rcsb pdb:3WPH|rcsb pdb:3WPI|go:"GO:0032725"(positive regulation of granulocyte macrophage colony-stimulating factor production)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032741"(positive regulation of interleukin-18 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0034122"(negative regulation of toll-like receptor signaling pathway)|go:"GO:0034123"(positive regulation of toll-like receptor signaling pathway)|go:"GO:0034162"(toll-like receptor 9 signaling pathway)|go:"GO:0034163"(regulation of toll-like receptor 9 signaling pathway)|go:"GO:0034165"(positive regulation of toll-like receptor 9 signaling pathway)|go:"GO:0035197"(siRNA binding)|go:"GO:0036019"(endolysosome)|go:"GO:0038187"(pattern recognition receptor activity)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0032722"(positive regulation of chemokine production)	rgd:620011|interpro:IPR000131(ATPase, F1 complex, gamma subunit)|interpro:IPR023632|mint:P35435|interpro:IPR035968|go:"GO:0000275"("mitochondrial proton-transporting ATP synthase complex, catalytic sector F(1)")|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005753"(mitochondrial proton-transporting ATP synthase complex)|go:"GO:0015986"(ATP synthesis coupled proton transport)|go:"GO:0042776"(mitochondrial ATP synthesis coupled proton transport)|go:"GO:0045261"("proton-transporting ATP synthase complex, catalytic core F(1)")|go:"GO:0046034"(ATP metabolic process)|go:"GO:0046933"(proton-transporting ATP synthase activity, rotational mechanism)|go:"GO:0071732"(cellular response to nitric oxide)|rcsb pdb:1MAB|rcsb pdb:2F43|reactome:R-RNO-163210|reactome:R-RNO-8949613	-	-	-	figure legend:sf1b f1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat-cardiac_myocytes)|taxid:10116(rat cardiac myocytes)	-	2014/11/18	2014/11/18	rogid:3XKXj7PkEGE5qOchJfjMHFREkT010090	rogid:py9RCXV2/aoMy8UslZteKeJAdak10116	intact-crc:70A3FF53549AB406|rigid:8b0W4ZmSLQHpG6EH8YyUNdlAlZE	false	calmodulin binding peptide plus protein a tag:c-c	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9EQU3	uniprotkb:O35824	intact:EBI-9979528|ensembl:ENSMUSP00000082207|uniprotkb:F8VPN5|uniprotkb:Q4L0K3|uniprotkb:Q4L0K4|uniprotkb:Q99MF2|uniprotkb:Q99MQ8	intact:EBI-1187217	psi-mi:tlr9_mouse(display_long)|uniprotkb:Tlr9(gene name)|psi-mi:Tlr9(display_short)	psi-mi:dnja2_rat(display_long)|uniprotkb:RDJ2(gene name synonym)|uniprotkb:Dnaja2(gene name)|psi-mi:Dnaja2(display_short)	psi-mi:"MI:0676"(tandem affinity purification)	Shintani et al. (2014)	imex:IM-23524|pubmed:24610369	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-9979511|imex:IM-23524-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000045322(gene)|ensembl:ENSMUST00000062241(transcript)|go:"GO:0001774"(microglial cell activation)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0002224"(toll-like receptor signaling pathway)|go:"GO:0002237"(response to molecule of bacterial origin)|go:"GO:0002639"(positive regulation of immunoglobulin production)|go:"GO:0002730"(regulation of dendritic cell cytokine production)|go:"GO:0002755"(MyD88-dependent toll-like receptor signaling pathway)|go:"GO:0005149"(interleukin-1 receptor binding)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|refseq:NP_112455.2|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0045087"(innate immune response)|go:"GO:0045322"(unmethylated CpG binding)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0045577"(regulation of B cell differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0050864"(regulation of B cell activation)|go:"GO:0050871"(positive regulation of B cell activation)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051607"(defense response to virus)|go:"GO:0051770"(positive regulation of nitric-oxide synthase biosynthetic process)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071248"(cellular response to metal ion)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:0005886"(plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0007252"(I-kappaB phosphorylation)|go:"GO:0008584"(male gonad development)|go:"GO:0009615"(response to virus)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030277"(maintenance of gastrointestinal epithelium)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0032009"(early phagosome)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032717"(negative regulation of interleukin-8 production)|go:"GO:0005789"(endoplasmic reticulum membrane)|rcsb pdb:4QDH|rcsb pdb:5ZLN|reactome:R-MMU-109704|reactome:R-MMU-1679131|reactome:R-MMU-168138|go:"GO:1901895"(negative regulation of ATPase-coupled calcium transmembrane transporter activity)|go:"GO:1902350"(cellular response to chloroquine)|interpro:IPR000157(Toll-Interleukin receptor)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR027181|interpro:IPR035897|interpro:IPR041283|mint:Q9EQU3|rcsb pdb:3WPF|rcsb pdb:3WPG|rcsb pdb:3WPH|rcsb pdb:3WPI|go:"GO:0032725"(positive regulation of granulocyte macrophage colony-stimulating factor production)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032741"(positive regulation of interleukin-18 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0034122"(negative regulation of toll-like receptor signaling pathway)|go:"GO:0034123"(positive regulation of toll-like receptor signaling pathway)|go:"GO:0034162"(toll-like receptor 9 signaling pathway)|go:"GO:0034163"(regulation of toll-like receptor 9 signaling pathway)|go:"GO:0034165"(positive regulation of toll-like receptor 9 signaling pathway)|go:"GO:0035197"(siRNA binding)|go:"GO:0036019"(endolysosome)|go:"GO:0038187"(pattern recognition receptor activity)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0032722"(positive regulation of chemokine production)	interpro:IPR001305(Heat shock protein DnaJ, cysteine-rich region)|rgd:71001|interpro:IPR012724(Chaperone DnaJ)|interpro:IPR002939(Chaperone DnaJ, C-terminal)|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR018253|interpro:IPR008971(HSP40/DnaJ peptide-binding)|go:"GO:0001671"(ATPase activator activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0009408"(response to heat)|go:"GO:0016020"(membrane)|go:"GO:0018885"(carbon tetrachloride metabolic process)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0042026"(protein refolding)|go:"GO:0046872"(metal ion binding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051087"(chaperone binding)|reactome:R-RNO-3371497|mint:O35824|interpro:IPR036410|interpro:IPR036869|interpro:IPR044713	-	-	-	figure legend:sf1b f1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat-cardiac_myocytes)|taxid:10116(rat cardiac myocytes)	-	2014/11/18	2014/11/18	rogid:3XKXj7PkEGE5qOchJfjMHFREkT010090	rogid:msgM7nFOH7krpYMCrW4lzOOcAmA10116	intact-crc:70A3FF53549AB406|rigid:8b0W4ZmSLQHpG6EH8YyUNdlAlZE	false	calmodulin binding peptide plus protein a tag:c-c	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9EQU3	uniprotkb:P23928	intact:EBI-9979528|ensembl:ENSMUSP00000082207|uniprotkb:F8VPN5|uniprotkb:Q4L0K3|uniprotkb:Q4L0K4|uniprotkb:Q99MF2|uniprotkb:Q99MQ8	intact:EBI-916888|uniprotkb:Q6LDR2|ensembl:ENSRNOP00000055901	psi-mi:tlr9_mouse(display_long)|uniprotkb:Tlr9(gene name)|psi-mi:Tlr9(display_short)	psi-mi:cryab_rat(display_long)|uniprotkb:"Alpha(B)-crystallin"(gene name synonym)|uniprotkb:Cryab(gene name)|psi-mi:Cryab(display_short)	psi-mi:"MI:0676"(tandem affinity purification)	Shintani et al. (2014)	imex:IM-23524|pubmed:24610369	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-9979511|imex:IM-23524-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000045322(gene)|ensembl:ENSMUST00000062241(transcript)|go:"GO:0001774"(microglial cell activation)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0002224"(toll-like receptor signaling pathway)|go:"GO:0002237"(response to molecule of bacterial origin)|go:"GO:0002639"(positive regulation of immunoglobulin production)|go:"GO:0002730"(regulation of dendritic cell cytokine production)|go:"GO:0002755"(MyD88-dependent toll-like receptor signaling pathway)|go:"GO:0005149"(interleukin-1 receptor binding)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|refseq:NP_112455.2|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0045087"(innate immune response)|go:"GO:0045322"(unmethylated CpG binding)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0045577"(regulation of B cell differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0050864"(regulation of B cell activation)|go:"GO:0050871"(positive regulation of B cell activation)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051607"(defense response to virus)|go:"GO:0051770"(positive regulation of nitric-oxide synthase biosynthetic process)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071248"(cellular response to metal ion)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:0005886"(plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0007252"(I-kappaB phosphorylation)|go:"GO:0008584"(male gonad development)|go:"GO:0009615"(response to virus)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030277"(maintenance of gastrointestinal epithelium)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0032009"(early phagosome)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032717"(negative regulation of interleukin-8 production)|go:"GO:0005789"(endoplasmic reticulum membrane)|rcsb pdb:4QDH|rcsb pdb:5ZLN|reactome:R-MMU-109704|reactome:R-MMU-1679131|reactome:R-MMU-168138|go:"GO:1901895"(negative regulation of ATPase-coupled calcium transmembrane transporter activity)|go:"GO:1902350"(cellular response to chloroquine)|interpro:IPR000157(Toll-Interleukin receptor)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR027181|interpro:IPR035897|interpro:IPR041283|mint:Q9EQU3|rcsb pdb:3WPF|rcsb pdb:3WPG|rcsb pdb:3WPH|rcsb pdb:3WPI|go:"GO:0032725"(positive regulation of granulocyte macrophage colony-stimulating factor production)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032741"(positive regulation of interleukin-18 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0034122"(negative regulation of toll-like receptor signaling pathway)|go:"GO:0034123"(positive regulation of toll-like receptor signaling pathway)|go:"GO:0034162"(toll-like receptor 9 signaling pathway)|go:"GO:0034163"(regulation of toll-like receptor 9 signaling pathway)|go:"GO:0034165"(positive regulation of toll-like receptor 9 signaling pathway)|go:"GO:0035197"(siRNA binding)|go:"GO:0036019"(endolysosome)|go:"GO:0038187"(pattern recognition receptor activity)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0032722"(positive regulation of chemokine production)	rgd:2414|refseq:NP_037067.1|ensembl:ENSRNOG00000010524(gene)|ensembl:ENSRNOT00000059127(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002088"(lens development in camera-type eye)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005212"(structural constituent of eye lens)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006457"(protein folding)|go:"GO:0007021"(tubulin complex assembly)|go:"GO:0007517"(muscle organ development)|go:"GO:0007568"(aging)|go:"GO:0008017"(microtubule binding)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0009986"(cell surface)|go:"GO:0010259"(multicellular organism aging)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010941"(regulation of cell death)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0030018"(Z disc)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030424"(axon)|go:"GO:0031109"(microtubule polymerization or depolymerization)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0031430"(M band)|go:"GO:0031674"(I band)|go:"GO:0032355"(response to estradiol)|go:"GO:0032387"(negative regulation of intracellular transport)|go:"GO:0032432"(actin filament bundle)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043010"(camera-type eye development)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043197"(dendritic spine)|go:"GO:0043204"(perikaryon)|go:"GO:0043292"(contractile fiber)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046872"(metal ion binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051403"(stress-activated MAPK cascade)|go:"GO:0060561"(apoptotic process involved in morphogenesis)|go:"GO:0071480"(cellular response to gamma radiation)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097512"(cardiac myofibril)|go:"GO:1905907"(negative regulation of amyloid fibril formation)|go:"GO:2000378"(negative regulation of reactive oxygen species metabolic process)|interpro:IPR001436(Alpha crystallin/Heat shock protein)|interpro:IPR002068(Heat shock protein Hsp20)|interpro:IPR003090(Alpha-crystallin, N-terminal)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR037882|mint:P23928|reactome:R-RNO-3371571	-	-	-	figure legend:sf1b f1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat-cardiac_myocytes)|taxid:10116(rat cardiac myocytes)	-	2014/11/18	2014/11/18	rogid:3XKXj7PkEGE5qOchJfjMHFREkT010090	rogid:WVFpAMy4PxYCruNm6Y0UT6+kAmo10116	intact-crc:70A3FF53549AB406|rigid:8b0W4ZmSLQHpG6EH8YyUNdlAlZE	false	calmodulin binding peptide plus protein a tag:c-c	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9EQU3	uniprotkb:Q62703	intact:EBI-9979528|ensembl:ENSMUSP00000082207|uniprotkb:F8VPN5|uniprotkb:Q4L0K3|uniprotkb:Q4L0K4|uniprotkb:Q99MF2|uniprotkb:Q99MQ8	intact:EBI-9979590|uniprotkb:Q6P6X5|ensembl:ENSRNOP00000021817	psi-mi:tlr9_mouse(display_long)|uniprotkb:Tlr9(gene name)|psi-mi:Tlr9(display_short)	psi-mi:rcn2_rat(display_long)|uniprotkb:Rcn2(gene name)|psi-mi:Rcn2(display_short)|uniprotkb:Erc55(gene name synonym)|uniprotkb:Calcium-binding protein ERC-55(gene name synonym)|uniprotkb:Taipoxin-associated calcium-binding protein 49(gene name synonym)	psi-mi:"MI:0676"(tandem affinity purification)	Shintani et al. (2014)	imex:IM-23524|pubmed:24610369	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-9979511|imex:IM-23524-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000045322(gene)|ensembl:ENSMUST00000062241(transcript)|go:"GO:0001774"(microglial cell activation)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0002224"(toll-like receptor signaling pathway)|go:"GO:0002237"(response to molecule of bacterial origin)|go:"GO:0002639"(positive regulation of immunoglobulin production)|go:"GO:0002730"(regulation of dendritic cell cytokine production)|go:"GO:0002755"(MyD88-dependent toll-like receptor signaling pathway)|go:"GO:0005149"(interleukin-1 receptor binding)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|refseq:NP_112455.2|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0045087"(innate immune response)|go:"GO:0045322"(unmethylated CpG binding)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0045577"(regulation of B cell differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0050864"(regulation of B cell activation)|go:"GO:0050871"(positive regulation of B cell activation)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051607"(defense response to virus)|go:"GO:0051770"(positive regulation of nitric-oxide synthase biosynthetic process)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071248"(cellular response to metal ion)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:0005886"(plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0007252"(I-kappaB phosphorylation)|go:"GO:0008584"(male gonad development)|go:"GO:0009615"(response to virus)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030277"(maintenance of gastrointestinal epithelium)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0032009"(early phagosome)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032717"(negative regulation of interleukin-8 production)|go:"GO:0005789"(endoplasmic reticulum membrane)|rcsb pdb:4QDH|rcsb pdb:5ZLN|reactome:R-MMU-109704|reactome:R-MMU-1679131|reactome:R-MMU-168138|go:"GO:1901895"(negative regulation of ATPase-coupled calcium transmembrane transporter activity)|go:"GO:1902350"(cellular response to chloroquine)|interpro:IPR000157(Toll-Interleukin receptor)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR027181|interpro:IPR035897|interpro:IPR041283|mint:Q9EQU3|rcsb pdb:3WPF|rcsb pdb:3WPG|rcsb pdb:3WPH|rcsb pdb:3WPI|go:"GO:0032725"(positive regulation of granulocyte macrophage colony-stimulating factor production)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032741"(positive regulation of interleukin-18 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0034122"(negative regulation of toll-like receptor signaling pathway)|go:"GO:0034123"(positive regulation of toll-like receptor signaling pathway)|go:"GO:0034162"(toll-like receptor 9 signaling pathway)|go:"GO:0034163"(regulation of toll-like receptor 9 signaling pathway)|go:"GO:0034165"(positive regulation of toll-like receptor 9 signaling pathway)|go:"GO:0035197"(siRNA binding)|go:"GO:0036019"(endolysosome)|go:"GO:0038187"(pattern recognition receptor activity)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0032722"(positive regulation of chemokine production)	refseq:NP_058828.2|rgd:3548|ensembl:ENSRNOG00000015780(gene)|ensembl:ENSRNOT00000021817(transcript)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005730"(nucleolus)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005788"(endoplasmic reticulum lumen)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|mint:Q62703	-	-	-	figure legend:sf1b f1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat-cardiac_myocytes)|taxid:10116(rat cardiac myocytes)	-	2014/11/18	2014/11/18	rogid:3XKXj7PkEGE5qOchJfjMHFREkT010090	rogid:6sN8PDsM+GbuhxWQ3bEBdedfY3g10116	intact-crc:70A3FF53549AB406|rigid:8b0W4ZmSLQHpG6EH8YyUNdlAlZE	false	calmodulin binding peptide plus protein a tag:c-c	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9EQU3	uniprotkb:P62246	intact:EBI-9979528|ensembl:ENSMUSP00000082207|uniprotkb:F8VPN5|uniprotkb:Q4L0K3|uniprotkb:Q4L0K4|uniprotkb:Q99MF2|uniprotkb:Q99MQ8	intact:EBI-347883|ensembl:ENSRNOP00000024678|ensembl:ENSRNOP00000075747|ensembl:ENSRNOP00000075906|uniprotkb:P39027|uniprotkb:P39031|uniprotkb:Q8C023|uniprotkb:Q9BV24	psi-mi:tlr9_mouse(display_long)|uniprotkb:Tlr9(gene name)|psi-mi:Tlr9(display_short)	psi-mi:rs15a_rat(display_long)|uniprotkb:Rps15a(gene name)|psi-mi:Rps15a(display_short)	psi-mi:"MI:0676"(tandem affinity purification)	Shintani et al. (2014)	imex:IM-23524|pubmed:24610369	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-9979511|imex:IM-23524-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000045322(gene)|ensembl:ENSMUST00000062241(transcript)|go:"GO:0001774"(microglial cell activation)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0002224"(toll-like receptor signaling pathway)|go:"GO:0002237"(response to molecule of bacterial origin)|go:"GO:0002639"(positive regulation of immunoglobulin production)|go:"GO:0002730"(regulation of dendritic cell cytokine production)|go:"GO:0002755"(MyD88-dependent toll-like receptor signaling pathway)|go:"GO:0005149"(interleukin-1 receptor binding)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|refseq:NP_112455.2|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0045087"(innate immune response)|go:"GO:0045322"(unmethylated CpG binding)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0045577"(regulation of B cell differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0050864"(regulation of B cell activation)|go:"GO:0050871"(positive regulation of B cell activation)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051607"(defense response to virus)|go:"GO:0051770"(positive regulation of nitric-oxide synthase biosynthetic process)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071248"(cellular response to metal ion)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:0005886"(plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0007252"(I-kappaB phosphorylation)|go:"GO:0008584"(male gonad development)|go:"GO:0009615"(response to virus)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030277"(maintenance of gastrointestinal epithelium)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0032009"(early phagosome)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032717"(negative regulation of interleukin-8 production)|go:"GO:0005789"(endoplasmic reticulum membrane)|rcsb pdb:4QDH|rcsb pdb:5ZLN|reactome:R-MMU-109704|reactome:R-MMU-1679131|reactome:R-MMU-168138|go:"GO:1901895"(negative regulation of ATPase-coupled calcium transmembrane transporter activity)|go:"GO:1902350"(cellular response to chloroquine)|interpro:IPR000157(Toll-Interleukin receptor)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR027181|interpro:IPR035897|interpro:IPR041283|mint:Q9EQU3|rcsb pdb:3WPF|rcsb pdb:3WPG|rcsb pdb:3WPH|rcsb pdb:3WPI|go:"GO:0032725"(positive regulation of granulocyte macrophage colony-stimulating factor production)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032741"(positive regulation of interleukin-18 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0034122"(negative regulation of toll-like receptor signaling pathway)|go:"GO:0034123"(positive regulation of toll-like receptor signaling pathway)|go:"GO:0034162"(toll-like receptor 9 signaling pathway)|go:"GO:0034163"(regulation of toll-like receptor 9 signaling pathway)|go:"GO:0034165"(positive regulation of toll-like receptor 9 signaling pathway)|go:"GO:0035197"(siRNA binding)|go:"GO:0036019"(endolysosome)|go:"GO:0038187"(pattern recognition receptor activity)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0032722"(positive regulation of chemokine production)	ensembl:ENSRNOG00000018320(gene)|ensembl:ENSRNOT00000024678(transcript)|ensembl:ENSRNOT00000092282(transcript)|ensembl:ENSRNOT00000092513(transcript)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005737"(cytoplasm)|go:"GO:0006412"(translation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009615"(response to virus)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0022627"(cytosolic small ribosomal subunit)|go:"GO:0045787"(positive regulation of cell cycle)|interpro:IPR000630(Ribosomal protein S8)|interpro:IPR035987|mint:P62246|reactome:R-RNO-156827|reactome:R-RNO-1799339|reactome:R-RNO-6791226|reactome:R-RNO-72649|reactome:R-RNO-72689|reactome:R-RNO-72695|reactome:R-RNO-72702|reactome:R-RNO-72706|reactome:R-RNO-975956|reactome:R-RNO-975957|rgd:619939|refseq:NP_446434.1|refseq:XP_006230159.1|refseq:XP_006230160.1	-	-	-	figure legend:sf1b f1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat-cardiac_myocytes)|taxid:10116(rat cardiac myocytes)	-	2014/11/18	2014/11/18	rogid:3XKXj7PkEGE5qOchJfjMHFREkT010090	rogid:Qdnhk7yvoFFYcRq5kEi7GQILaxs10116	intact-crc:70A3FF53549AB406|rigid:8b0W4ZmSLQHpG6EH8YyUNdlAlZE	false	calmodulin binding peptide plus protein a tag:c-c	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9EQU3	uniprotkb:P63018	intact:EBI-9979528|ensembl:ENSMUSP00000082207|uniprotkb:F8VPN5|uniprotkb:Q4L0K3|uniprotkb:Q4L0K4|uniprotkb:Q99MF2|uniprotkb:Q99MQ8	intact:EBI-433431|uniprotkb:P08109|uniprotkb:P12225|uniprotkb:Q4FZY7|uniprotkb:Q62373|uniprotkb:Q62374|uniprotkb:Q62375	psi-mi:tlr9_mouse(display_long)|uniprotkb:Tlr9(gene name)|psi-mi:Tlr9(display_short)	psi-mi:hsp7c_rat(display_long)|uniprotkb:Hspa8(gene name)|psi-mi:Hspa8(display_short)|uniprotkb:Hsc70(gene name synonym)|uniprotkb:Heat shock 70 kDa protein 8(gene name synonym)|uniprotkb:Hsc73(gene name synonym)	psi-mi:"MI:0676"(tandem affinity purification)	Shintani et al. (2014)	imex:IM-23524|pubmed:24610369	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-9979511|imex:IM-23524-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000045322(gene)|ensembl:ENSMUST00000062241(transcript)|go:"GO:0001774"(microglial cell activation)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0002224"(toll-like receptor signaling pathway)|go:"GO:0002237"(response to molecule of bacterial origin)|go:"GO:0002639"(positive regulation of immunoglobulin production)|go:"GO:0002730"(regulation of dendritic cell cytokine production)|go:"GO:0002755"(MyD88-dependent toll-like receptor signaling pathway)|go:"GO:0005149"(interleukin-1 receptor binding)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|refseq:NP_112455.2|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0045087"(innate immune response)|go:"GO:0045322"(unmethylated CpG binding)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0045577"(regulation of B cell differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0050864"(regulation of B cell activation)|go:"GO:0050871"(positive regulation of B cell activation)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051607"(defense response to virus)|go:"GO:0051770"(positive regulation of nitric-oxide synthase biosynthetic process)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071248"(cellular response to metal ion)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:0005886"(plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0007252"(I-kappaB phosphorylation)|go:"GO:0008584"(male gonad development)|go:"GO:0009615"(response to virus)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030277"(maintenance of gastrointestinal epithelium)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0032009"(early phagosome)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032717"(negative regulation of interleukin-8 production)|go:"GO:0005789"(endoplasmic reticulum membrane)|rcsb pdb:4QDH|rcsb pdb:5ZLN|reactome:R-MMU-109704|reactome:R-MMU-1679131|reactome:R-MMU-168138|go:"GO:1901895"(negative regulation of ATPase-coupled calcium transmembrane transporter activity)|go:"GO:1902350"(cellular response to chloroquine)|interpro:IPR000157(Toll-Interleukin receptor)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR027181|interpro:IPR035897|interpro:IPR041283|mint:Q9EQU3|rcsb pdb:3WPF|rcsb pdb:3WPG|rcsb pdb:3WPH|rcsb pdb:3WPI|go:"GO:0032725"(positive regulation of granulocyte macrophage colony-stimulating factor production)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032741"(positive regulation of interleukin-18 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0034122"(negative regulation of toll-like receptor signaling pathway)|go:"GO:0034123"(positive regulation of toll-like receptor signaling pathway)|go:"GO:0034162"(toll-like receptor 9 signaling pathway)|go:"GO:0034163"(regulation of toll-like receptor 9 signaling pathway)|go:"GO:0034165"(positive regulation of toll-like receptor 9 signaling pathway)|go:"GO:0035197"(siRNA binding)|go:"GO:0036019"(endolysosome)|go:"GO:0038187"(pattern recognition receptor activity)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0032722"(positive regulation of chemokine production)	rgd:621725|refseq:NP_077327.1|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0000974"(Prp19 complex)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0001822"(kidney development)|go:"GO:0001916"(positive regulation of T cell mediated cytotoxicity)|go:"GO:0001917"(photoreceptor inner segment)|go:"GO:0003723"(RNA binding)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005770"(late endosome)|go:"GO:0005776"(autophagosome)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005882"(intermediate filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0006397"(mRNA processing)|go:"GO:0006457"(protein folding)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0007519"(skeletal muscle tissue development)|go:"GO:0007568"(aging)|go:"GO:0007608"(sensory perception of smell)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008088"(axo-dendritic transport)|go:"GO:0008380"(RNA splicing)|go:"GO:0009408"(response to heat)|go:"GO:0009986"(cell surface)|go:"GO:0010045"(response to nickel cation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010667"(negative regulation of cardiac muscle cell apoptotic process)|go:"GO:0014069"(postsynaptic density)|go:"GO:0014823"(response to activity)|go:"GO:0016191"(synaptic vesicle uncoating)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0019899"(enzyme binding)|go:"GO:0021549"(cerebellum development)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030900"(forebrain development)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031686"(A1 adenosine receptor binding)|go:"GO:0032279"(asymmetric synapse)|go:"GO:0032355"(response to estradiol)|go:"GO:0032570"(response to progesterone)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034605"(cellular response to heat)|go:"GO:0034620"(cellular response to unfolded protein)|go:"GO:0042026"(protein refolding)|go:"GO:0042277"(peptide binding)|go:"GO:0042470"(melanosome)|go:"GO:0042493"|go:"GO:0042594"(response to starvation)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043085"(positive regulation of catalytic activity)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043204"(perikaryon)|go:"GO:0043531"(ADP binding)|go:"GO:0043624"|go:"GO:0044183"(protein folding chaperone)|go:"GO:0044309"(neuron spine)|go:"GO:0044743"(protein transmembrane import into intracellular organelle)|go:"GO:0044788"(modulation by host of viral process)|go:"GO:0044829"(positive regulation by host of viral genome replication)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0045862"(positive regulation of proteolysis)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046034"(ATP metabolic process)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048026"(positive regulation of mRNA splicing, via spliceosome)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051787"(misfolded protein binding)|go:"GO:0055131"(C3HC4-type RING finger domain binding)|go:"GO:0061077"(chaperone-mediated protein folding)|go:"GO:0061635"(regulation of protein complex stability)|go:"GO:0061684"(chaperone-mediated autophagy)|go:"GO:0061738"(late endosomal microautophagy)|go:"GO:0061740"(protein targeting to lysosome involved in chaperone-mediated autophagy)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0072318"(clathrin coat disassembly)|go:"GO:0097214"(positive regulation of lysosomal membrane permeability)|go:"GO:0044849"(estrous cycle)|go:"GO:0098684"(photoreceptor ribbon synapse)|go:"GO:0098690"(glycinergic synapse)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098880"(maintenance of postsynaptic specialization structure)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099175"(regulation of postsynapse organization)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099634"(postsynaptic specialization membrane)|go:"GO:0101031"(chaperone complex)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1902904"(negative regulation of supramolecular fiber organization)|go:"GO:1903206"(negative regulation of hydrogen peroxide-induced cell death)|go:"GO:1904592"(positive regulation of protein refolding)|go:"GO:1904593"(prostaglandin binding)|go:"GO:1904764"(chaperone-mediated autophagy translocation complex disassembly)|go:"GO:1990124"(messenger ribonucleoprotein complex)|go:"GO:1990832"(slow axonal transport)|go:"GO:1990833"(clathrin-uncoating ATPase activity)|go:"GO:1990834"(response to odorant)|go:"GO:1990836"(lysosomal matrix)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR013126(Heat shock protein 70)|interpro:IPR018181|interpro:IPR029047|interpro:IPR029048|interpro:IPR043129|rcsb pdb:1CKR|rcsb pdb:1Q2G|rcsb pdb:1UD0|rcsb pdb:2V7Z|rcsb pdb:7HSC|mint:P63018|dip:DIP-33262N	-	-	-	figure legend:sf1b f1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat-cardiac_myocytes)|taxid:10116(rat cardiac myocytes)	-	2014/11/18	2014/11/18	rogid:3XKXj7PkEGE5qOchJfjMHFREkT010090	rogid:WDnUczLfoe3ODQbiEITN3DfQnFA10116	intact-crc:70A3FF53549AB406|rigid:8b0W4ZmSLQHpG6EH8YyUNdlAlZE	false	calmodulin binding peptide plus protein a tag:c-c	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9EQU3	uniprotkb:P62850	intact:EBI-9979528|ensembl:ENSMUSP00000082207|uniprotkb:F8VPN5|uniprotkb:Q4L0K3|uniprotkb:Q4L0K4|uniprotkb:Q99MF2|uniprotkb:Q99MQ8	intact:EBI-354479|uniprotkb:Q6PEC9|uniprotkb:P16632	psi-mi:tlr9_mouse(display_long)|uniprotkb:Tlr9(gene name)|psi-mi:Tlr9(display_short)	psi-mi:rs24_rat(display_long)|uniprotkb:Rps24(gene name)|psi-mi:Rps24(display_short)	psi-mi:"MI:0676"(tandem affinity purification)	Shintani et al. (2014)	imex:IM-23524|pubmed:24610369	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-9979511|imex:IM-23524-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000045322(gene)|ensembl:ENSMUST00000062241(transcript)|go:"GO:0001774"(microglial cell activation)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0002224"(toll-like receptor signaling pathway)|go:"GO:0002237"(response to molecule of bacterial origin)|go:"GO:0002639"(positive regulation of immunoglobulin production)|go:"GO:0002730"(regulation of dendritic cell cytokine production)|go:"GO:0002755"(MyD88-dependent toll-like receptor signaling pathway)|go:"GO:0005149"(interleukin-1 receptor binding)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|refseq:NP_112455.2|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0045087"(innate immune response)|go:"GO:0045322"(unmethylated CpG binding)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0045577"(regulation of B cell differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0050864"(regulation of B cell activation)|go:"GO:0050871"(positive regulation of B cell activation)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051607"(defense response to virus)|go:"GO:0051770"(positive regulation of nitric-oxide synthase biosynthetic process)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071248"(cellular response to metal ion)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:0005886"(plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0007252"(I-kappaB phosphorylation)|go:"GO:0008584"(male gonad development)|go:"GO:0009615"(response to virus)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030277"(maintenance of gastrointestinal epithelium)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0032009"(early phagosome)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032717"(negative regulation of interleukin-8 production)|go:"GO:0005789"(endoplasmic reticulum membrane)|rcsb pdb:4QDH|rcsb pdb:5ZLN|reactome:R-MMU-109704|reactome:R-MMU-1679131|reactome:R-MMU-168138|go:"GO:1901895"(negative regulation of ATPase-coupled calcium transmembrane transporter activity)|go:"GO:1902350"(cellular response to chloroquine)|interpro:IPR000157(Toll-Interleukin receptor)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR027181|interpro:IPR035897|interpro:IPR041283|mint:Q9EQU3|rcsb pdb:3WPF|rcsb pdb:3WPG|rcsb pdb:3WPH|rcsb pdb:3WPI|go:"GO:0032725"(positive regulation of granulocyte macrophage colony-stimulating factor production)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032741"(positive regulation of interleukin-18 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0034122"(negative regulation of toll-like receptor signaling pathway)|go:"GO:0034123"(positive regulation of toll-like receptor signaling pathway)|go:"GO:0034162"(toll-like receptor 9 signaling pathway)|go:"GO:0034163"(regulation of toll-like receptor 9 signaling pathway)|go:"GO:0034165"(positive regulation of toll-like receptor 9 signaling pathway)|go:"GO:0035197"(siRNA binding)|go:"GO:0036019"(endolysosome)|go:"GO:0038187"(pattern recognition receptor activity)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0032722"(positive regulation of chemokine production)	rgd:621040|refseq:NP_112374.1|interpro:IPR012678(Ribosomal protein L23/L15e, core)|interpro:IPR001976(Ribosomal protein S24e)|interpro:IPR018098|refseq:XP_006252593.1|refseq:XP_006252594.1|refseq:XP_006252595.1|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005840"(ribosome)|go:"GO:0006364"(rRNA processing)|go:"GO:0006413"(translational initiation)|go:"GO:0015935"(small ribosomal subunit)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0022627"(cytosolic small ribosomal subunit)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0034101"(erythrocyte homeostasis)|go:"GO:0042274"(ribosomal small subunit biogenesis)|go:"GO:0097421"(liver regeneration)|reactome:R-RNO-156827|reactome:R-RNO-1799339|reactome:R-RNO-6791226|reactome:R-RNO-72649|reactome:R-RNO-72689|reactome:R-RNO-72695|reactome:R-RNO-72702|reactome:R-RNO-72706|reactome:R-RNO-975956|reactome:R-RNO-975957|mint:P62850	-	-	-	figure legend:sf1b f1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat-cardiac_myocytes)|taxid:10116(rat cardiac myocytes)	-	2014/11/18	2014/11/18	rogid:3XKXj7PkEGE5qOchJfjMHFREkT010090	rogid:M/qkRxabHx9PFaOM7EwKDOOwu7Q10116	intact-crc:70A3FF53549AB406|rigid:8b0W4ZmSLQHpG6EH8YyUNdlAlZE	false	calmodulin binding peptide plus protein a tag:c-c	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9EQU3	uniprotkb:P62832	intact:EBI-9979528|ensembl:ENSMUSP00000082207|uniprotkb:F8VPN5|uniprotkb:Q4L0K3|uniprotkb:Q4L0K4|uniprotkb:Q99MF2|uniprotkb:Q99MQ8	intact:EBI-353333|ensembl:ENSRNOP00000005471|uniprotkb:P23131|uniprotkb:Q29246|uniprotkb:P24048	psi-mi:tlr9_mouse(display_long)|uniprotkb:Tlr9(gene name)|psi-mi:Tlr9(display_short)	psi-mi:rl23_rat(display_long)|uniprotkb:Rpl23(gene name)|psi-mi:Rpl23(display_short)	psi-mi:"MI:0676"(tandem affinity purification)	Shintani et al. (2014)	imex:IM-23524|pubmed:24610369	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-9979511|imex:IM-23524-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000045322(gene)|ensembl:ENSMUST00000062241(transcript)|go:"GO:0001774"(microglial cell activation)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0002224"(toll-like receptor signaling pathway)|go:"GO:0002237"(response to molecule of bacterial origin)|go:"GO:0002639"(positive regulation of immunoglobulin production)|go:"GO:0002730"(regulation of dendritic cell cytokine production)|go:"GO:0002755"(MyD88-dependent toll-like receptor signaling pathway)|go:"GO:0005149"(interleukin-1 receptor binding)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|refseq:NP_112455.2|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0045087"(innate immune response)|go:"GO:0045322"(unmethylated CpG binding)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0045577"(regulation of B cell differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0050864"(regulation of B cell activation)|go:"GO:0050871"(positive regulation of B cell activation)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051607"(defense response to virus)|go:"GO:0051770"(positive regulation of nitric-oxide synthase biosynthetic process)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071248"(cellular response to metal ion)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:0005886"(plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0007252"(I-kappaB phosphorylation)|go:"GO:0008584"(male gonad development)|go:"GO:0009615"(response to virus)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030277"(maintenance of gastrointestinal epithelium)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0032009"(early phagosome)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032717"(negative regulation of interleukin-8 production)|go:"GO:0005789"(endoplasmic reticulum membrane)|rcsb pdb:4QDH|rcsb pdb:5ZLN|reactome:R-MMU-109704|reactome:R-MMU-1679131|reactome:R-MMU-168138|go:"GO:1901895"(negative regulation of ATPase-coupled calcium transmembrane transporter activity)|go:"GO:1902350"(cellular response to chloroquine)|interpro:IPR000157(Toll-Interleukin receptor)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR027181|interpro:IPR035897|interpro:IPR041283|mint:Q9EQU3|rcsb pdb:3WPF|rcsb pdb:3WPG|rcsb pdb:3WPH|rcsb pdb:3WPI|go:"GO:0032725"(positive regulation of granulocyte macrophage colony-stimulating factor production)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032741"(positive regulation of interleukin-18 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0034122"(negative regulation of toll-like receptor signaling pathway)|go:"GO:0034123"(positive regulation of toll-like receptor signaling pathway)|go:"GO:0034162"(toll-like receptor 9 signaling pathway)|go:"GO:0034163"(regulation of toll-like receptor 9 signaling pathway)|go:"GO:0034165"(positive regulation of toll-like receptor 9 signaling pathway)|go:"GO:0035197"(siRNA binding)|go:"GO:0036019"(endolysosome)|go:"GO:0038187"(pattern recognition receptor activity)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0032722"(positive regulation of chemokine production)	ensembl:ENSRNOG00000004107(gene)|ensembl:ENSRNOT00000005471(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001223"(transcription coactivator binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005840"(ribosome)|go:"GO:0006412"(translation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0014069"(postsynaptic density)|go:"GO:0022625"(cytosolic large ribosomal subunit)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032986"(protein-DNA complex disassembly)|go:"GO:0032991"(protein-containing complex)|go:"GO:0050821"(protein stabilization)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070180"(large ribosomal subunit rRNA binding)|go:"GO:0072717"(cellular response to actinomycin D)|go:"GO:1901798"(positive regulation of signal transduction by p53 class mediator)|go:"GO:1904667"(negative regulation of ubiquitin protein ligase activity)|go:"GO:1990948"(ubiquitin ligase inhibitor activity)|go:"GO:2000059"(negative regulation of ubiquitin-dependent protein catabolic process)|interpro:IPR000218(Ribosomal protein L14b/L23e)|interpro:IPR019972|interpro:IPR036853|mint:P62832|reactome:R-RNO-156827|reactome:R-RNO-1799339|reactome:R-RNO-6791226|reactome:R-RNO-72689|reactome:R-RNO-72706|reactome:R-RNO-975956|rgd:62067|refseq:NP_001007600.1|reactome:R-RNO-975957	-	-	-	figure legend:sf1b f1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat-cardiac_myocytes)|taxid:10116(rat cardiac myocytes)	-	2014/11/18	2014/11/18	rogid:3XKXj7PkEGE5qOchJfjMHFREkT010090	rogid:TiSVU2W4+lkwf12eb4+vG6IFlZA10116	intact-crc:70A3FF53549AB406|rigid:8b0W4ZmSLQHpG6EH8YyUNdlAlZE	false	calmodulin binding peptide plus protein a tag:c-c	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9EQU3	uniprotkb:B2RZD6	intact:EBI-9979528|ensembl:ENSMUSP00000082207|uniprotkb:F8VPN5|uniprotkb:Q4L0K3|uniprotkb:Q4L0K4|uniprotkb:Q99MF2|uniprotkb:Q99MQ8	intact:EBI-9979513|ensembl:ENSRNOP00000007567	psi-mi:tlr9_mouse(display_long)|uniprotkb:Tlr9(gene name)|psi-mi:Tlr9(display_short)	psi-mi:b2rzd6_rat(display_long)|uniprotkb:Ndufa4(gene name)|psi-mi:Ndufa4(display_short)|uniprotkb:rCG_28086(orf name)	psi-mi:"MI:0676"(tandem affinity purification)	Shintani et al. (2014)	imex:IM-23524|pubmed:24610369	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-9979511|imex:IM-23524-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000045322(gene)|ensembl:ENSMUST00000062241(transcript)|go:"GO:0001774"(microglial cell activation)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0002224"(toll-like receptor signaling pathway)|go:"GO:0002237"(response to molecule of bacterial origin)|go:"GO:0002639"(positive regulation of immunoglobulin production)|go:"GO:0002730"(regulation of dendritic cell cytokine production)|go:"GO:0002755"(MyD88-dependent toll-like receptor signaling pathway)|go:"GO:0005149"(interleukin-1 receptor binding)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|refseq:NP_112455.2|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0045087"(innate immune response)|go:"GO:0045322"(unmethylated CpG binding)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0045577"(regulation of B cell differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0050864"(regulation of B cell activation)|go:"GO:0050871"(positive regulation of B cell activation)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051607"(defense response to virus)|go:"GO:0051770"(positive regulation of nitric-oxide synthase biosynthetic process)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071248"(cellular response to metal ion)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:0005886"(plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0007252"(I-kappaB phosphorylation)|go:"GO:0008584"(male gonad development)|go:"GO:0009615"(response to virus)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030277"(maintenance of gastrointestinal epithelium)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0032009"(early phagosome)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032717"(negative regulation of interleukin-8 production)|go:"GO:0005789"(endoplasmic reticulum membrane)|rcsb pdb:4QDH|rcsb pdb:5ZLN|reactome:R-MMU-109704|reactome:R-MMU-1679131|reactome:R-MMU-168138|go:"GO:1901895"(negative regulation of ATPase-coupled calcium transmembrane transporter activity)|go:"GO:1902350"(cellular response to chloroquine)|interpro:IPR000157(Toll-Interleukin receptor)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR027181|interpro:IPR035897|interpro:IPR041283|mint:Q9EQU3|rcsb pdb:3WPF|rcsb pdb:3WPG|rcsb pdb:3WPH|rcsb pdb:3WPI|go:"GO:0032725"(positive regulation of granulocyte macrophage colony-stimulating factor production)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032741"(positive regulation of interleukin-18 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0034122"(negative regulation of toll-like receptor signaling pathway)|go:"GO:0034123"(positive regulation of toll-like receptor signaling pathway)|go:"GO:0034162"(toll-like receptor 9 signaling pathway)|go:"GO:0034163"(regulation of toll-like receptor 9 signaling pathway)|go:"GO:0034165"(positive regulation of toll-like receptor 9 signaling pathway)|go:"GO:0035197"(siRNA binding)|go:"GO:0036019"(endolysosome)|go:"GO:0038187"(pattern recognition receptor activity)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0032722"(positive regulation of chemokine production)	go:"GO:0005747"(mitochondrial respiratory chain complex I)|go:"GO:0005751"(mitochondrial respiratory chain complex IV)|go:"GO:0022900"(electron transport chain)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:1902600"(proton transmembrane transport)|go:"GO:1904960"(positive regulation of cytochrome-c oxidase activity)|interpro:IPR010530(B12D)|mint:B2RZD6|reactome:R-RNO-5628897|reactome:R-RNO-611105|reactome:R-RNO-9707564|ensembl:ENSRNOG00000005512(gene)|ensembl:ENSRNOT00000007567(transcript)|go:"GO:0005739"(mitochondrion)|refseq:NP_001121156.1|rgd:1584719	-	-	-	figure legend:sf1b f1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat-cardiac_myocytes)|taxid:10116(rat cardiac myocytes)	-	2014/11/18	2014/11/18	rogid:3XKXj7PkEGE5qOchJfjMHFREkT010090	rogid:jHsaW6CL4Rm/cNbZXlwU02m7dlE10116	intact-crc:70A3FF53549AB406|rigid:8b0W4ZmSLQHpG6EH8YyUNdlAlZE	false	calmodulin binding peptide plus protein a tag:c-c	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9EQU3	uniprotkb:P10719	intact:EBI-9979528|ensembl:ENSMUSP00000082207|uniprotkb:F8VPN5|uniprotkb:Q4L0K3|uniprotkb:Q4L0K4|uniprotkb:Q99MF2|uniprotkb:Q99MQ8	intact:EBI-916266|uniprotkb:Q499W0	psi-mi:tlr9_mouse(display_long)|uniprotkb:Tlr9(gene name)|psi-mi:Tlr9(display_short)	psi-mi:atpb_rat(display_long)|uniprotkb:Atp5f1b(gene name)|psi-mi:Atp5f1b(display_short)|uniprotkb:ATP synthase F1 subunit beta(gene name synonym)|uniprotkb:Atp5b(gene name synonym)	psi-mi:"MI:0676"(tandem affinity purification)	Shintani et al. (2014)	imex:IM-23524|pubmed:24610369	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-9979511|imex:IM-23524-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000045322(gene)|ensembl:ENSMUST00000062241(transcript)|go:"GO:0001774"(microglial cell activation)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0002224"(toll-like receptor signaling pathway)|go:"GO:0002237"(response to molecule of bacterial origin)|go:"GO:0002639"(positive regulation of immunoglobulin production)|go:"GO:0002730"(regulation of dendritic cell cytokine production)|go:"GO:0002755"(MyD88-dependent toll-like receptor signaling pathway)|go:"GO:0005149"(interleukin-1 receptor binding)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|refseq:NP_112455.2|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0045087"(innate immune response)|go:"GO:0045322"(unmethylated CpG binding)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0045577"(regulation of B cell differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0050864"(regulation of B cell activation)|go:"GO:0050871"(positive regulation of B cell activation)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051607"(defense response to virus)|go:"GO:0051770"(positive regulation of nitric-oxide synthase biosynthetic process)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071248"(cellular response to metal ion)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:0005886"(plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0007252"(I-kappaB phosphorylation)|go:"GO:0008584"(male gonad development)|go:"GO:0009615"(response to virus)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030277"(maintenance of gastrointestinal epithelium)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0032009"(early phagosome)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032717"(negative regulation of interleukin-8 production)|go:"GO:0005789"(endoplasmic reticulum membrane)|rcsb pdb:4QDH|rcsb pdb:5ZLN|reactome:R-MMU-109704|reactome:R-MMU-1679131|reactome:R-MMU-168138|go:"GO:1901895"(negative regulation of ATPase-coupled calcium transmembrane transporter activity)|go:"GO:1902350"(cellular response to chloroquine)|interpro:IPR000157(Toll-Interleukin receptor)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR027181|interpro:IPR035897|interpro:IPR041283|mint:Q9EQU3|rcsb pdb:3WPF|rcsb pdb:3WPG|rcsb pdb:3WPH|rcsb pdb:3WPI|go:"GO:0032725"(positive regulation of granulocyte macrophage colony-stimulating factor production)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032741"(positive regulation of interleukin-18 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0034122"(negative regulation of toll-like receptor signaling pathway)|go:"GO:0034123"(positive regulation of toll-like receptor signaling pathway)|go:"GO:0034162"(toll-like receptor 9 signaling pathway)|go:"GO:0034163"(regulation of toll-like receptor 9 signaling pathway)|go:"GO:0034165"(positive regulation of toll-like receptor 9 signaling pathway)|go:"GO:0035197"(siRNA binding)|go:"GO:0036019"(endolysosome)|go:"GO:0038187"(pattern recognition receptor activity)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0032722"(positive regulation of chemokine production)	rgd:621368|refseq:NP_599191.1|interpro:IPR020003|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR004100(ATPase, F1/V1/A1 complex, alpha/beta subunit, N-terminal)|interpro:IPR000194(ATPase, F1/V1/A1 complex, alpha/beta subunit, nucleotide-binding)|interpro:IPR024034|interpro:IPR005722(ATPase, F1 complex, beta subunit)|go:"GO:0000275"("mitochondrial proton-transporting ATP synthase complex, catalytic sector F(1)")|go:"GO:0001525"(angiogenesis)|go:"GO:0001889"(liver development)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005753"(mitochondrial proton-transporting ATP synthase complex)|go:"GO:0005886"(plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0006754"(ATP biosynthetic process)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0006933"(negative regulation of cell adhesion involved in substrate-bound cell migration)|go:"GO:0009631"(cold acclimation)|go:"GO:0009986"(cell surface)|go:"GO:0010042"(response to manganese ion)|go:"GO:0016020"(membrane)|go:"GO:0030228"(lipoprotein particle receptor activity)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0042288"(MHC class I protein binding)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0042776"(mitochondrial ATP synthesis coupled proton transport)|go:"GO:0043531"(ADP binding)|go:"GO:0043532"(angiostatin binding)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0045121"(membrane raft)|go:"GO:0045259"(proton-transporting ATP synthase complex)|go:"GO:0045261"("proton-transporting ATP synthase complex, catalytic core F(1)")|go:"GO:0046034"(ATP metabolic process)|go:"GO:0046933"(proton-transporting ATP synthase activity, rotational mechanism)|go:"GO:0046961"(proton-transporting ATPase activity, rotational mechanism)|go:"GO:0051453"(regulation of intracellular pH)|go:"GO:0098761"(cellular response to interleukin-7)|go:"GO:1901653"(cellular response to peptide)|go:"GO:1902600"(proton transmembrane transport)|go:"GO:1904643"(response to curcumin)|go:"GO:1905242"(response to 3,3',5-triiodo-L-thyronine)|rcsb pdb:1MAB|rcsb pdb:2F43|reactome:R-RNO-1268020|reactome:R-RNO-163210|reactome:R-RNO-8949613|interpro:IPR027417|mint:P10719|interpro:IPR036121	-	-	-	figure legend:sf1b f1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat-cardiac_myocytes)|taxid:10116(rat cardiac myocytes)	-	2014/11/18	2014/11/18	rogid:3XKXj7PkEGE5qOchJfjMHFREkT010090	rogid:K1RREEkTYSnEnU2leNpq3SCa3wc10116	intact-crc:70A3FF53549AB406|rigid:8b0W4ZmSLQHpG6EH8YyUNdlAlZE	false	calmodulin binding peptide plus protein a tag:c-c	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9EQU3	uniprotkb:P21913	intact:EBI-9979528|ensembl:ENSMUSP00000082207|uniprotkb:F8VPN5|uniprotkb:Q4L0K3|uniprotkb:Q4L0K4|uniprotkb:Q99MF2|uniprotkb:Q99MQ8	intact:EBI-1225045|uniprotkb:B0BMZ2|uniprotkb:Q0QEZ3|ensembl:ENSRNOP00000010593	psi-mi:tlr9_mouse(display_long)|uniprotkb:Tlr9(gene name)|psi-mi:Tlr9(display_short)	psi-mi:sdhb_rat(display_long)|uniprotkb:Sdhb(gene name)|psi-mi:Sdhb(display_short)|uniprotkb:Sdh1(gene name synonym)|uniprotkb:Iron-sulfur subunit of complex II(gene name synonym)	psi-mi:"MI:0676"(tandem affinity purification)	Shintani et al. (2014)	imex:IM-23524|pubmed:24610369	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-9979511|imex:IM-23524-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000045322(gene)|ensembl:ENSMUST00000062241(transcript)|go:"GO:0001774"(microglial cell activation)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0002224"(toll-like receptor signaling pathway)|go:"GO:0002237"(response to molecule of bacterial origin)|go:"GO:0002639"(positive regulation of immunoglobulin production)|go:"GO:0002730"(regulation of dendritic cell cytokine production)|go:"GO:0002755"(MyD88-dependent toll-like receptor signaling pathway)|go:"GO:0005149"(interleukin-1 receptor binding)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|refseq:NP_112455.2|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0045087"(innate immune response)|go:"GO:0045322"(unmethylated CpG binding)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0045577"(regulation of B cell differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0050864"(regulation of B cell activation)|go:"GO:0050871"(positive regulation of B cell activation)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051607"(defense response to virus)|go:"GO:0051770"(positive regulation of nitric-oxide synthase biosynthetic process)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071248"(cellular response to metal ion)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:0005886"(plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0007252"(I-kappaB phosphorylation)|go:"GO:0008584"(male gonad development)|go:"GO:0009615"(response to virus)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030277"(maintenance of gastrointestinal epithelium)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0032009"(early phagosome)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032717"(negative regulation of interleukin-8 production)|go:"GO:0005789"(endoplasmic reticulum membrane)|rcsb pdb:4QDH|rcsb pdb:5ZLN|reactome:R-MMU-109704|reactome:R-MMU-1679131|reactome:R-MMU-168138|go:"GO:1901895"(negative regulation of ATPase-coupled calcium transmembrane transporter activity)|go:"GO:1902350"(cellular response to chloroquine)|interpro:IPR000157(Toll-Interleukin receptor)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR027181|interpro:IPR035897|interpro:IPR041283|mint:Q9EQU3|rcsb pdb:3WPF|rcsb pdb:3WPG|rcsb pdb:3WPH|rcsb pdb:3WPI|go:"GO:0032725"(positive regulation of granulocyte macrophage colony-stimulating factor production)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032741"(positive regulation of interleukin-18 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0034122"(negative regulation of toll-like receptor signaling pathway)|go:"GO:0034123"(positive regulation of toll-like receptor signaling pathway)|go:"GO:0034162"(toll-like receptor 9 signaling pathway)|go:"GO:0034163"(regulation of toll-like receptor 9 signaling pathway)|go:"GO:0034165"(positive regulation of toll-like receptor 9 signaling pathway)|go:"GO:0035197"(siRNA binding)|go:"GO:0036019"(endolysosome)|go:"GO:0038187"(pattern recognition receptor activity)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0032722"(positive regulation of chemokine production)	rgd:1308598|refseq:NP_001094009.1|ensembl:ENSRNOG00000007967(gene)|ensembl:ENSRNOT00000010593(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005749"("mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)")|go:"GO:0005886"(plasma membrane)|go:"GO:0006099"(tricarboxylic acid cycle)|go:"GO:0006105"(succinate metabolic process)|go:"GO:0008177"("succinate dehydrogenase (ubiquinone) activity")|go:"GO:0009055"(electron transfer activity)|go:"GO:0009060"(aerobic respiration)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0045273"(respiratory chain complex II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048039"(ubiquinone binding)|go:"GO:0051537"(2 iron, 2 sulfur cluster binding)|go:"GO:0051538"(3 iron, 4 sulfur cluster binding)|go:"GO:0051539"(4 iron, 4 sulfur cluster binding)|interpro:IPR001041(Ferredoxin)|interpro:IPR004489(Succinate dehydrogenase/fumarate reductase iron-sulphur protein)|interpro:IPR006058(2Fe-2S ferredoxin, iron-sulphur binding site)|interpro:IPR009051(Alpha-helical ferredoxin)|interpro:IPR012675(Beta-grasp fold, ferredoxin-type)|interpro:IPR017896|interpro:IPR017900|interpro:IPR025192|interpro:IPR036010|mint:P21913|reactome:R-RNO-71403|go:"GO:0005739"(mitochondrion)	-	-	-	figure legend:sf1b f1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat-cardiac_myocytes)|taxid:10116(rat cardiac myocytes)	-	2014/11/18	2014/11/18	rogid:3XKXj7PkEGE5qOchJfjMHFREkT010090	rogid:uAB7GUGt1Auy9Q9Nvfp8x8xdJQM10116	intact-crc:70A3FF53549AB406|rigid:8b0W4ZmSLQHpG6EH8YyUNdlAlZE	false	calmodulin binding peptide plus protein a tag:c-c	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9EQU3	uniprotkb:Q80ZB2	intact:EBI-9979528|ensembl:ENSMUSP00000082207|uniprotkb:F8VPN5|uniprotkb:Q4L0K3|uniprotkb:Q4L0K4|uniprotkb:Q99MF2|uniprotkb:Q99MQ8	intact:EBI-9979609	psi-mi:tlr9_mouse(display_long)|uniprotkb:Tlr9(gene name)|psi-mi:Tlr9(display_short)	psi-mi:q80zb2_rat(display_long)|uniprotkb:Abca1(gene name)|psi-mi:Abca1(display_short)	psi-mi:"MI:0676"(tandem affinity purification)	Shintani et al. (2014)	imex:IM-23524|pubmed:24610369	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-9979511|imex:IM-23524-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000045322(gene)|ensembl:ENSMUST00000062241(transcript)|go:"GO:0001774"(microglial cell activation)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0002224"(toll-like receptor signaling pathway)|go:"GO:0002237"(response to molecule of bacterial origin)|go:"GO:0002639"(positive regulation of immunoglobulin production)|go:"GO:0002730"(regulation of dendritic cell cytokine production)|go:"GO:0002755"(MyD88-dependent toll-like receptor signaling pathway)|go:"GO:0005149"(interleukin-1 receptor binding)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|refseq:NP_112455.2|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0045087"(innate immune response)|go:"GO:0045322"(unmethylated CpG binding)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0045577"(regulation of B cell differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0050864"(regulation of B cell activation)|go:"GO:0050871"(positive regulation of B cell activation)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051607"(defense response to virus)|go:"GO:0051770"(positive regulation of nitric-oxide synthase biosynthetic process)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071248"(cellular response to metal ion)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:0005886"(plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0007252"(I-kappaB phosphorylation)|go:"GO:0008584"(male gonad development)|go:"GO:0009615"(response to virus)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030277"(maintenance of gastrointestinal epithelium)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0032009"(early phagosome)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032717"(negative regulation of interleukin-8 production)|go:"GO:0005789"(endoplasmic reticulum membrane)|rcsb pdb:4QDH|rcsb pdb:5ZLN|reactome:R-MMU-109704|reactome:R-MMU-1679131|reactome:R-MMU-168138|go:"GO:1901895"(negative regulation of ATPase-coupled calcium transmembrane transporter activity)|go:"GO:1902350"(cellular response to chloroquine)|interpro:IPR000157(Toll-Interleukin receptor)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR027181|interpro:IPR035897|interpro:IPR041283|mint:Q9EQU3|rcsb pdb:3WPF|rcsb pdb:3WPG|rcsb pdb:3WPH|rcsb pdb:3WPI|go:"GO:0032725"(positive regulation of granulocyte macrophage colony-stimulating factor production)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032741"(positive regulation of interleukin-18 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0034122"(negative regulation of toll-like receptor signaling pathway)|go:"GO:0034123"(positive regulation of toll-like receptor signaling pathway)|go:"GO:0034162"(toll-like receptor 9 signaling pathway)|go:"GO:0034163"(regulation of toll-like receptor 9 signaling pathway)|go:"GO:0034165"(positive regulation of toll-like receptor 9 signaling pathway)|go:"GO:0035197"(siRNA binding)|go:"GO:0036019"(endolysosome)|go:"GO:0038187"(pattern recognition receptor activity)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0032722"(positive regulation of chemokine production)	go:"GO:0002790"(peptide secretion)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005319"(lipid transporter activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005548"(phospholipid transporter activity)|go:"GO:0005768"(endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006497"(protein lipidation)|go:"GO:0006869"(lipid transport)|go:"GO:0006911"(phagocytosis, engulfment)|go:"GO:0007040"(lysosome organization)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007584"(response to nutrient)|go:"GO:0008035"(high-density lipoprotein particle binding)|go:"GO:0008203"(cholesterol metabolic process)|go:"GO:0008320"(protein transmembrane transporter activity)|go:"GO:0009306"(protein secretion)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010875"(positive regulation of cholesterol efflux)|go:"GO:0015914"(phospholipid transport)|go:"GO:0016020"(membrane)|go:"GO:0016197"(endosomal transport)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0019905"(syntaxin binding)|go:"GO:0023061"(signal release)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0030301"(cholesterol transport)|go:"GO:0031210"(phosphatidylcholine binding)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0032367"(intracellular cholesterol transport)|go:"GO:0032489"(regulation of Cdc42 protein signal transduction)|go:"GO:0033344"(cholesterol efflux)|go:"GO:0033700"(phospholipid efflux)|go:"GO:0034185"(apolipoprotein binding)|go:"GO:0034186"(apolipoprotein A-I binding)|go:"GO:0034188"(apolipoprotein A-I receptor activity)|go:"GO:0034380"(high-density lipoprotein particle assembly)|go:"GO:0034616"(response to laminar fluid shear stress)|go:"GO:0035690"|go:"GO:0042157"(lipoprotein metabolic process)|go:"GO:0042158"(lipoprotein biosynthetic process)|go:"GO:0042493"|go:"GO:0042626"(ATPase-coupled transmembrane transporter activity)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043691"(reverse cholesterol transport)|go:"GO:0045121"(membrane raft)|go:"GO:0045332"(phospholipid translocation)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0046623"(sphingolipid floppase activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051117"(ATPase binding)|go:"GO:0055091"(phospholipid homeostasis)|go:"GO:0060155"(platelet dense granule organization)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0071397"(cellular response to cholesterol)|go:"GO:0071806"(protein transmembrane transport)|go:"GO:0090108"(positive regulation of high-density lipoprotein particle assembly)|go:"GO:0090554"(phosphatidylcholine floppase activity)|go:"GO:0090556"(phosphatidylserine floppase activity)|go:"GO:0097708"(intracellular vesicle)|go:"GO:0120020"(cholesterol transfer activity)|go:"GO:0140115"(export across plasma membrane)|go:"GO:0140328"(floppase activity)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR026082|interpro:IPR003439(ABC transporter-like)|interpro:IPR017871|interpro:IPR027417|rgd:631344|refseq:NP_835196.1|mint:Q80ZB2|interpro:IPR030365	-	-	-	figure legend:sf1b f1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat-cardiac_myocytes)|taxid:10116(rat cardiac myocytes)	-	2014/11/18	2014/11/18	rogid:3XKXj7PkEGE5qOchJfjMHFREkT010090	rogid:yk8q1Szi/ZWF9uLl491sEiFWmaM10116	intact-crc:70A3FF53549AB406|rigid:8b0W4ZmSLQHpG6EH8YyUNdlAlZE	false	calmodulin binding peptide plus protein a tag:c-c	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9EQU3	uniprotkb:P18418	intact:EBI-9979528|ensembl:ENSMUSP00000082207|uniprotkb:F8VPN5|uniprotkb:Q4L0K3|uniprotkb:Q4L0K4|uniprotkb:Q99MF2|uniprotkb:Q99MQ8	intact:EBI-916742|uniprotkb:P10452|ensembl:ENSRNOP00000004091	psi-mi:tlr9_mouse(display_long)|uniprotkb:Tlr9(gene name)|psi-mi:Tlr9(display_short)	psi-mi:calr_rat(display_long)|uniprotkb:CRP55(gene name synonym)|uniprotkb:Calregulin(gene name synonym)|uniprotkb:HACBP(gene name synonym)|uniprotkb:Endoplasmic reticulum resident protein 60(gene name synonym)|uniprotkb:CALBP(gene name synonym)|uniprotkb:Calcium-binding protein 3(gene name synonym)|uniprotkb:Calr(gene name)|psi-mi:Calr(display_short)	psi-mi:"MI:0676"(tandem affinity purification)	Shintani et al. (2014)	imex:IM-23524|pubmed:24610369	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-9979511|imex:IM-23524-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000045322(gene)|ensembl:ENSMUST00000062241(transcript)|go:"GO:0001774"(microglial cell activation)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0002224"(toll-like receptor signaling pathway)|go:"GO:0002237"(response to molecule of bacterial origin)|go:"GO:0002639"(positive regulation of immunoglobulin production)|go:"GO:0002730"(regulation of dendritic cell cytokine production)|go:"GO:0002755"(MyD88-dependent toll-like receptor signaling pathway)|go:"GO:0005149"(interleukin-1 receptor binding)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|refseq:NP_112455.2|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0045087"(innate immune response)|go:"GO:0045322"(unmethylated CpG binding)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0045577"(regulation of B cell differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0050864"(regulation of B cell activation)|go:"GO:0050871"(positive regulation of B cell activation)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051607"(defense response to virus)|go:"GO:0051770"(positive regulation of nitric-oxide synthase biosynthetic process)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071248"(cellular response to metal ion)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:0005886"(plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0007252"(I-kappaB phosphorylation)|go:"GO:0008584"(male gonad development)|go:"GO:0009615"(response to virus)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030277"(maintenance of gastrointestinal epithelium)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0032009"(early phagosome)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032717"(negative regulation of interleukin-8 production)|go:"GO:0005789"(endoplasmic reticulum membrane)|rcsb pdb:4QDH|rcsb pdb:5ZLN|reactome:R-MMU-109704|reactome:R-MMU-1679131|reactome:R-MMU-168138|go:"GO:1901895"(negative regulation of ATPase-coupled calcium transmembrane transporter activity)|go:"GO:1902350"(cellular response to chloroquine)|interpro:IPR000157(Toll-Interleukin receptor)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR027181|interpro:IPR035897|interpro:IPR041283|mint:Q9EQU3|rcsb pdb:3WPF|rcsb pdb:3WPG|rcsb pdb:3WPH|rcsb pdb:3WPI|go:"GO:0032725"(positive regulation of granulocyte macrophage colony-stimulating factor production)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032741"(positive regulation of interleukin-18 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0034122"(negative regulation of toll-like receptor signaling pathway)|go:"GO:0034123"(positive regulation of toll-like receptor signaling pathway)|go:"GO:0034162"(toll-like receptor 9 signaling pathway)|go:"GO:0034163"(regulation of toll-like receptor 9 signaling pathway)|go:"GO:0034165"(positive regulation of toll-like receptor 9 signaling pathway)|go:"GO:0035197"(siRNA binding)|go:"GO:0036019"(endolysosome)|go:"GO:0038187"(pattern recognition receptor activity)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0032722"(positive regulation of chemokine production)	rgd:620288|refseq:NP_071794.1|ensembl:ENSRNOG00000003029(gene)|ensembl:ENSRNOT00000004091(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0002502"(peptide antigen assembly with MHC class I protein complex)|go:"GO:0003729"(mRNA binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005506"(iron ion binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0006457"(protein folding)|go:"GO:0006611"(protein export from nucleus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010033"(response to organic substance)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016020"(membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0030866"(cortical actin cytoskeleton organization)|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032355"(response to estradiol)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033018"(sarcoplasmic reticulum lumen)|go:"GO:0033144"(negative regulation of intracellular steroid hormone receptor signaling pathway)|go:"GO:0033574"(response to testosterone)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0040020"(regulation of meiotic nuclear division)|go:"GO:0042277"(peptide binding)|go:"GO:0042493"|go:"GO:0042562"(hormone binding)|go:"GO:0042824"(MHC class I peptide loading complex)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044322"(endoplasmic reticulum quality control compartment)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045787"(positive regulation of cell cycle)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048387"(negative regulation of retinoic acid receptor signaling pathway)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050681"(androgen receptor binding)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0060473"(cortical granule)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0071285"(cellular response to lithium ion)|go:"GO:0071310"(cellular response to organic substance)|go:"GO:0090398"(cellular senescence)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1901164"(negative regulation of trophoblast cell migration)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:2000510"(positive regulation of dendritic cell chemotaxis)|interpro:IPR001580(Calreticulin/calnexin)|interpro:IPR009033(Calreticulin/calnexin, P)|interpro:IPR009169(Calreticulin)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR018124|mint:P18418|rcsb pdb:1HHN|rcsb pdb:1K91|rcsb pdb:1K9C|reactome:R-RNO-1236974|reactome:R-RNO-3000480|reactome:R-RNO-901042|reactome:R-RNO-983170	-	-	-	figure legend:sf1b f1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat-cardiac_myocytes)|taxid:10116(rat cardiac myocytes)	-	2014/11/18	2014/11/18	rogid:3XKXj7PkEGE5qOchJfjMHFREkT010090	rogid:mFrLbrHGBN1Bxc+erHTyfw1NwMw10116	intact-crc:70A3FF53549AB406|rigid:8b0W4ZmSLQHpG6EH8YyUNdlAlZE	false	calmodulin binding peptide plus protein a tag:c-c	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9EQU3	uniprotkb:P62864	intact:EBI-9979528|ensembl:ENSMUSP00000082207|uniprotkb:F8VPN5|uniprotkb:Q4L0K3|uniprotkb:Q4L0K4|uniprotkb:Q99MF2|uniprotkb:Q99MQ8	intact:EBI-9979498|uniprotkb:Q05472|uniprotkb:Q95261	psi-mi:tlr9_mouse(display_long)|uniprotkb:Tlr9(gene name)|psi-mi:Tlr9(display_short)	psi-mi:rs30_rat(display_long)|uniprotkb:Fau(gene name)|psi-mi:Fau(display_short)	psi-mi:"MI:0676"(tandem affinity purification)	Shintani et al. (2014)	imex:IM-23524|pubmed:24610369	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-9979511|imex:IM-23524-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000045322(gene)|ensembl:ENSMUST00000062241(transcript)|go:"GO:0001774"(microglial cell activation)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0002224"(toll-like receptor signaling pathway)|go:"GO:0002237"(response to molecule of bacterial origin)|go:"GO:0002639"(positive regulation of immunoglobulin production)|go:"GO:0002730"(regulation of dendritic cell cytokine production)|go:"GO:0002755"(MyD88-dependent toll-like receptor signaling pathway)|go:"GO:0005149"(interleukin-1 receptor binding)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|refseq:NP_112455.2|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0045087"(innate immune response)|go:"GO:0045322"(unmethylated CpG binding)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0045577"(regulation of B cell differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0050864"(regulation of B cell activation)|go:"GO:0050871"(positive regulation of B cell activation)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051607"(defense response to virus)|go:"GO:0051770"(positive regulation of nitric-oxide synthase biosynthetic process)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071248"(cellular response to metal ion)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:0005886"(plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0007252"(I-kappaB phosphorylation)|go:"GO:0008584"(male gonad development)|go:"GO:0009615"(response to virus)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030277"(maintenance of gastrointestinal epithelium)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0032009"(early phagosome)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032717"(negative regulation of interleukin-8 production)|go:"GO:0005789"(endoplasmic reticulum membrane)|rcsb pdb:4QDH|rcsb pdb:5ZLN|reactome:R-MMU-109704|reactome:R-MMU-1679131|reactome:R-MMU-168138|go:"GO:1901895"(negative regulation of ATPase-coupled calcium transmembrane transporter activity)|go:"GO:1902350"(cellular response to chloroquine)|interpro:IPR000157(Toll-Interleukin receptor)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR027181|interpro:IPR035897|interpro:IPR041283|mint:Q9EQU3|rcsb pdb:3WPF|rcsb pdb:3WPG|rcsb pdb:3WPH|rcsb pdb:3WPI|go:"GO:0032725"(positive regulation of granulocyte macrophage colony-stimulating factor production)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032741"(positive regulation of interleukin-18 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0034122"(negative regulation of toll-like receptor signaling pathway)|go:"GO:0034123"(positive regulation of toll-like receptor signaling pathway)|go:"GO:0034162"(toll-like receptor 9 signaling pathway)|go:"GO:0034163"(regulation of toll-like receptor 9 signaling pathway)|go:"GO:0034165"(positive regulation of toll-like receptor 9 signaling pathway)|go:"GO:0035197"(siRNA binding)|go:"GO:0036019"(endolysosome)|go:"GO:0038187"(pattern recognition receptor activity)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0032722"(positive regulation of chemokine production)	go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005840"(ribosome)|go:"GO:0006412"(translation)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0061844"(antimicrobial humoral immune response mediated by antimicrobial peptide)|interpro:IPR006846(Ribosomal protein S30)|rgd:61938|mint:P62864	-	-	-	figure legend:sf1b f1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat-cardiac_myocytes)|taxid:10116(rat cardiac myocytes)	-	2014/11/18	2014/11/18	rogid:3XKXj7PkEGE5qOchJfjMHFREkT010090	rogid:mfW+tko85h9ZOK7wNXUsYiYY3Hc10116	intact-crc:70A3FF53549AB406|rigid:8b0W4ZmSLQHpG6EH8YyUNdlAlZE	false	calmodulin binding peptide plus protein a tag:c-c	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9EQU3	uniprotkb:P62250	intact:EBI-9979528|ensembl:ENSMUSP00000082207|uniprotkb:F8VPN5|uniprotkb:Q4L0K3|uniprotkb:Q4L0K4|uniprotkb:Q99MF2|uniprotkb:Q99MQ8	intact:EBI-352489|uniprotkb:P17008|ensembl:ENSRNOP00000026576	psi-mi:tlr9_mouse(display_long)|uniprotkb:Tlr9(gene name)|psi-mi:Tlr9(display_short)	psi-mi:rs16_rat(display_long)|uniprotkb:Rps16(gene name)|psi-mi:Rps16(display_short)	psi-mi:"MI:0676"(tandem affinity purification)	Shintani et al. (2014)	imex:IM-23524|pubmed:24610369	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-9979511|imex:IM-23524-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000045322(gene)|ensembl:ENSMUST00000062241(transcript)|go:"GO:0001774"(microglial cell activation)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0002224"(toll-like receptor signaling pathway)|go:"GO:0002237"(response to molecule of bacterial origin)|go:"GO:0002639"(positive regulation of immunoglobulin production)|go:"GO:0002730"(regulation of dendritic cell cytokine production)|go:"GO:0002755"(MyD88-dependent toll-like receptor signaling pathway)|go:"GO:0005149"(interleukin-1 receptor binding)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|refseq:NP_112455.2|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0045087"(innate immune response)|go:"GO:0045322"(unmethylated CpG binding)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0045577"(regulation of B cell differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0050864"(regulation of B cell activation)|go:"GO:0050871"(positive regulation of B cell activation)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051607"(defense response to virus)|go:"GO:0051770"(positive regulation of nitric-oxide synthase biosynthetic process)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071248"(cellular response to metal ion)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:0005886"(plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0007252"(I-kappaB phosphorylation)|go:"GO:0008584"(male gonad development)|go:"GO:0009615"(response to virus)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030277"(maintenance of gastrointestinal epithelium)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0032009"(early phagosome)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032717"(negative regulation of interleukin-8 production)|go:"GO:0005789"(endoplasmic reticulum membrane)|rcsb pdb:4QDH|rcsb pdb:5ZLN|reactome:R-MMU-109704|reactome:R-MMU-1679131|reactome:R-MMU-168138|go:"GO:1901895"(negative regulation of ATPase-coupled calcium transmembrane transporter activity)|go:"GO:1902350"(cellular response to chloroquine)|interpro:IPR000157(Toll-Interleukin receptor)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR027181|interpro:IPR035897|interpro:IPR041283|mint:Q9EQU3|rcsb pdb:3WPF|rcsb pdb:3WPG|rcsb pdb:3WPH|rcsb pdb:3WPI|go:"GO:0032725"(positive regulation of granulocyte macrophage colony-stimulating factor production)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032741"(positive regulation of interleukin-18 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0034122"(negative regulation of toll-like receptor signaling pathway)|go:"GO:0034123"(positive regulation of toll-like receptor signaling pathway)|go:"GO:0034162"(toll-like receptor 9 signaling pathway)|go:"GO:0034163"(regulation of toll-like receptor 9 signaling pathway)|go:"GO:0034165"(positive regulation of toll-like receptor 9 signaling pathway)|go:"GO:0035197"(siRNA binding)|go:"GO:0036019"(endolysosome)|go:"GO:0038187"(pattern recognition receptor activity)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0032722"(positive regulation of chemokine production)	rgd:621031|refseq:NP_001162617.1|ensembl:ENSRNOG00000019578(gene)|ensembl:ENSRNOT00000026576(transcript)|go:"GO:0000462"("maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)")|go:"GO:0003723"(RNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0006364"(rRNA processing)|go:"GO:0006412"(translation)|go:"GO:0015935"(small ribosomal subunit)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0022627"(cytosolic small ribosomal subunit)|go:"GO:0042274"(ribosomal small subunit biogenesis)|go:"GO:0097421"(liver regeneration)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|interpro:IPR000754(Ribosomal protein S9)|interpro:IPR014721(Ribosomal protein S5 domain 2-type fold)|interpro:IPR020568|interpro:IPR020574|mint:P62250|reactome:R-RNO-156827|reactome:R-RNO-1799339|reactome:R-RNO-6791226|reactome:R-RNO-72649|reactome:R-RNO-72689|reactome:R-RNO-72695|reactome:R-RNO-72702|reactome:R-RNO-72706|reactome:R-RNO-975956|reactome:R-RNO-975957	-	-	-	figure legend:sf1b f1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat-cardiac_myocytes)|taxid:10116(rat cardiac myocytes)	-	2014/11/18	2014/11/18	rogid:3XKXj7PkEGE5qOchJfjMHFREkT010090	rogid:OrKriR6HsATLaO+drdUa2w3Gpd010116	intact-crc:70A3FF53549AB406|rigid:8b0W4ZmSLQHpG6EH8YyUNdlAlZE	false	calmodulin binding peptide plus protein a tag:c-c	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9EQU3	uniprotkb:P51868	intact:EBI-9979528|ensembl:ENSMUSP00000082207|uniprotkb:F8VPN5|uniprotkb:Q4L0K3|uniprotkb:Q4L0K4|uniprotkb:Q99MF2|uniprotkb:Q99MQ8	intact:EBI-917722|uniprotkb:O09177|uniprotkb:Q6IMX1	psi-mi:tlr9_mouse(display_long)|uniprotkb:Tlr9(gene name)|psi-mi:Tlr9(display_short)	psi-mi:casq2_rat(display_long)|uniprotkb:Calsequestrin, cardiac muscle isoform(gene name synonym)|uniprotkb:Casq2(gene name)|psi-mi:Casq2(display_short)	psi-mi:"MI:0676"(tandem affinity purification)	Shintani et al. (2014)	imex:IM-23524|pubmed:24610369	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-9979511|imex:IM-23524-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000045322(gene)|ensembl:ENSMUST00000062241(transcript)|go:"GO:0001774"(microglial cell activation)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0002224"(toll-like receptor signaling pathway)|go:"GO:0002237"(response to molecule of bacterial origin)|go:"GO:0002639"(positive regulation of immunoglobulin production)|go:"GO:0002730"(regulation of dendritic cell cytokine production)|go:"GO:0002755"(MyD88-dependent toll-like receptor signaling pathway)|go:"GO:0005149"(interleukin-1 receptor binding)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|refseq:NP_112455.2|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0045087"(innate immune response)|go:"GO:0045322"(unmethylated CpG binding)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0045577"(regulation of B cell differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0050864"(regulation of B cell activation)|go:"GO:0050871"(positive regulation of B cell activation)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051607"(defense response to virus)|go:"GO:0051770"(positive regulation of nitric-oxide synthase biosynthetic process)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071248"(cellular response to metal ion)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:0005886"(plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0007252"(I-kappaB phosphorylation)|go:"GO:0008584"(male gonad development)|go:"GO:0009615"(response to virus)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030277"(maintenance of gastrointestinal epithelium)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0032009"(early phagosome)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032717"(negative regulation of interleukin-8 production)|go:"GO:0005789"(endoplasmic reticulum membrane)|rcsb pdb:4QDH|rcsb pdb:5ZLN|reactome:R-MMU-109704|reactome:R-MMU-1679131|reactome:R-MMU-168138|go:"GO:1901895"(negative regulation of ATPase-coupled calcium transmembrane transporter activity)|go:"GO:1902350"(cellular response to chloroquine)|interpro:IPR000157(Toll-Interleukin receptor)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR027181|interpro:IPR035897|interpro:IPR041283|mint:Q9EQU3|rcsb pdb:3WPF|rcsb pdb:3WPG|rcsb pdb:3WPH|rcsb pdb:3WPI|go:"GO:0032725"(positive regulation of granulocyte macrophage colony-stimulating factor production)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032741"(positive regulation of interleukin-18 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0034122"(negative regulation of toll-like receptor signaling pathway)|go:"GO:0034123"(positive regulation of toll-like receptor signaling pathway)|go:"GO:0034162"(toll-like receptor 9 signaling pathway)|go:"GO:0034163"(regulation of toll-like receptor 9 signaling pathway)|go:"GO:0034165"(positive regulation of toll-like receptor 9 signaling pathway)|go:"GO:0035197"(siRNA binding)|go:"GO:0036019"(endolysosome)|go:"GO:0038187"(pattern recognition receptor activity)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0032722"(positive regulation of chemokine production)	rgd:2276|refseq:NP_058827.3|interpro:IPR001393(Calsequestrin)|interpro:IPR018233|go:"GO:0002027"(regulation of heart rate)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0010649"(regulation of cell communication by electrical coupling)|go:"GO:0010880"(regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum)|go:"GO:0010881"(regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0030018"(Z disc)|go:"GO:0030314"(junctional membrane complex)|go:"GO:0033018"(sarcoplasmic reticulum lumen)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043267"(negative regulation of potassium ion transport)|go:"GO:0045214"(sarcomere organization)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0051208"(sequestering of calcium ion)|go:"GO:0051258"(protein polymerization)|go:"GO:0051279"(regulation of release of sequestered calcium ion into cytosol)|go:"GO:0060048"(cardiac muscle contraction)|go:"GO:0060306"(regulation of membrane repolarization)|go:"GO:0060315"(negative regulation of ryanodine-sensitive calcium-release channel activity)|go:"GO:0071313"(cellular response to caffeine)|go:"GO:0086004"(regulation of cardiac muscle cell contraction)|go:"GO:1901017"(negative regulation of potassium ion transmembrane transporter activity)|reactome:R-RNO-2672351|reactome:R-RNO-5578775|mint:P51868|interpro:IPR036249|interpro:IPR041858|interpro:IPR041859|interpro:IPR041860	-	-	-	figure legend:sf1b f1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat-cardiac_myocytes)|taxid:10116(rat cardiac myocytes)	-	2014/11/18	2014/11/18	rogid:3XKXj7PkEGE5qOchJfjMHFREkT010090	rogid:7iJwnAEOBYCPFh2MZkEWjAPQhNE10116	intact-crc:70A3FF53549AB406|rigid:8b0W4ZmSLQHpG6EH8YyUNdlAlZE	false	calmodulin binding peptide plus protein a tag:c-c	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9EQU3	uniprotkb:P15999	intact:EBI-9979528|ensembl:ENSMUSP00000082207|uniprotkb:F8VPN5|uniprotkb:Q4L0K3|uniprotkb:Q4L0K4|uniprotkb:Q99MF2|uniprotkb:Q99MQ8	intact:EBI-916646|uniprotkb:Q6P753	psi-mi:tlr9_mouse(display_long)|uniprotkb:Tlr9(gene name)|psi-mi:Tlr9(display_short)	psi-mi:atpa_rat(display_long)|uniprotkb:Atp5f1a(gene name)|psi-mi:Atp5f1a(display_short)|uniprotkb:ATP synthase F1 subunit alpha(gene name synonym)|uniprotkb:Atp5a1(gene name synonym)	psi-mi:"MI:0676"(tandem affinity purification)	Shintani et al. (2014)	imex:IM-23524|pubmed:24610369	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-9979511|imex:IM-23524-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000045322(gene)|ensembl:ENSMUST00000062241(transcript)|go:"GO:0001774"(microglial cell activation)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0002224"(toll-like receptor signaling pathway)|go:"GO:0002237"(response to molecule of bacterial origin)|go:"GO:0002639"(positive regulation of immunoglobulin production)|go:"GO:0002730"(regulation of dendritic cell cytokine production)|go:"GO:0002755"(MyD88-dependent toll-like receptor signaling pathway)|go:"GO:0005149"(interleukin-1 receptor binding)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|refseq:NP_112455.2|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0045087"(innate immune response)|go:"GO:0045322"(unmethylated CpG binding)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0045577"(regulation of B cell differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0050864"(regulation of B cell activation)|go:"GO:0050871"(positive regulation of B cell activation)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051607"(defense response to virus)|go:"GO:0051770"(positive regulation of nitric-oxide synthase biosynthetic process)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071248"(cellular response to metal ion)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:0005886"(plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0007252"(I-kappaB phosphorylation)|go:"GO:0008584"(male gonad development)|go:"GO:0009615"(response to virus)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030277"(maintenance of gastrointestinal epithelium)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0032009"(early phagosome)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032717"(negative regulation of interleukin-8 production)|go:"GO:0005789"(endoplasmic reticulum membrane)|rcsb pdb:4QDH|rcsb pdb:5ZLN|reactome:R-MMU-109704|reactome:R-MMU-1679131|reactome:R-MMU-168138|go:"GO:1901895"(negative regulation of ATPase-coupled calcium transmembrane transporter activity)|go:"GO:1902350"(cellular response to chloroquine)|interpro:IPR000157(Toll-Interleukin receptor)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR027181|interpro:IPR035897|interpro:IPR041283|mint:Q9EQU3|rcsb pdb:3WPF|rcsb pdb:3WPG|rcsb pdb:3WPH|rcsb pdb:3WPI|go:"GO:0032725"(positive regulation of granulocyte macrophage colony-stimulating factor production)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032741"(positive regulation of interleukin-18 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0034122"(negative regulation of toll-like receptor signaling pathway)|go:"GO:0034123"(positive regulation of toll-like receptor signaling pathway)|go:"GO:0034162"(toll-like receptor 9 signaling pathway)|go:"GO:0034163"(regulation of toll-like receptor 9 signaling pathway)|go:"GO:0034165"(positive regulation of toll-like receptor 9 signaling pathway)|go:"GO:0035197"(siRNA binding)|go:"GO:0036019"(endolysosome)|go:"GO:0038187"(pattern recognition receptor activity)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0032722"(positive regulation of chemokine production)	rgd:619993|refseq:NP_075581.1|interpro:IPR020003|interpro:IPR005294(ATPase, F1 complex, alpha subunit)|interpro:IPR023366|interpro:IPR000793(ATPase, F1/V1/A1 complex, alpha/beta subunit, C-terminal)|interpro:IPR004100(ATPase, F1/V1/A1 complex, alpha/beta subunit, N-terminal)|interpro:IPR000194(ATPase, F1/V1/A1 complex, alpha/beta subunit, nucleotide-binding)|interpro:IPR033732|interpro:IPR027417|mint:P15999|interpro:IPR038376|interpro:IPR036121|go:"GO:0000275"("mitochondrial proton-transporting ATP synthase complex, catalytic sector F(1)")|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0002020"(protease binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005753"(mitochondrial proton-transporting ATP synthase complex)|go:"GO:0005754"(mitochondrial proton-transporting ATP synthase, catalytic core)|go:"GO:0005886"(plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0006754"(ATP biosynthetic process)|go:"GO:0006915"(apoptotic process)|go:"GO:0007568"(aging)|go:"GO:0009986"(cell surface)|go:"GO:0014850"(response to muscle activity)|go:"GO:0015986"(ATP synthesis coupled proton transport)|go:"GO:0016020"(membrane)|go:"GO:0042288"(MHC class I protein binding)|go:"GO:0042776"(mitochondrial ATP synthesis coupled proton transport)|go:"GO:0043531"(ADP binding)|go:"GO:0043532"(angiostatin binding)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0045121"(membrane raft)|go:"GO:0045259"(proton-transporting ATP synthase complex)|go:"GO:0045261"("proton-transporting ATP synthase complex, catalytic core F(1)")|go:"GO:0045471"(response to ethanol)|go:"GO:0046034"(ATP metabolic process)|go:"GO:0046933"(proton-transporting ATP synthase activity, rotational mechanism)|go:"GO:0071549"(cellular response to dexamethasone stimulus)|go:"GO:0071732"(cellular response to nitric oxide)|rcsb pdb:1MAB|rcsb pdb:2F43	-	-	-	figure legend:sf1b f1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat-cardiac_myocytes)|taxid:10116(rat cardiac myocytes)	-	2014/11/18	2014/11/18	rogid:3XKXj7PkEGE5qOchJfjMHFREkT010090	rogid:Jkbhz0cHR3egHpKo/n1Ex4EbnUI10116	intact-crc:70A3FF53549AB406|rigid:8b0W4ZmSLQHpG6EH8YyUNdlAlZE	false	calmodulin binding peptide plus protein a tag:c-c	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9EQU3	uniprotkb:P35565	intact:EBI-9979528|ensembl:ENSMUSP00000082207|uniprotkb:F8VPN5|uniprotkb:Q4L0K3|uniprotkb:Q4L0K4|uniprotkb:Q99MF2|uniprotkb:Q99MQ8	intact:EBI-917363|ensembl:ENSRNOP00000040859	psi-mi:tlr9_mouse(display_long)|uniprotkb:Tlr9(gene name)|psi-mi:Tlr9(display_short)	psi-mi:calx_rat(display_long)|uniprotkb:Canx(gene name)|psi-mi:Canx(display_short)	psi-mi:"MI:0676"(tandem affinity purification)	Shintani et al. (2014)	imex:IM-23524|pubmed:24610369	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-9979511|imex:IM-23524-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000045322(gene)|ensembl:ENSMUST00000062241(transcript)|go:"GO:0001774"(microglial cell activation)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0002224"(toll-like receptor signaling pathway)|go:"GO:0002237"(response to molecule of bacterial origin)|go:"GO:0002639"(positive regulation of immunoglobulin production)|go:"GO:0002730"(regulation of dendritic cell cytokine production)|go:"GO:0002755"(MyD88-dependent toll-like receptor signaling pathway)|go:"GO:0005149"(interleukin-1 receptor binding)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|refseq:NP_112455.2|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0045087"(innate immune response)|go:"GO:0045322"(unmethylated CpG binding)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0045577"(regulation of B cell differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0050864"(regulation of B cell activation)|go:"GO:0050871"(positive regulation of B cell activation)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051607"(defense response to virus)|go:"GO:0051770"(positive regulation of nitric-oxide synthase biosynthetic process)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071248"(cellular response to metal ion)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:0005886"(plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0007252"(I-kappaB phosphorylation)|go:"GO:0008584"(male gonad development)|go:"GO:0009615"(response to virus)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030277"(maintenance of gastrointestinal epithelium)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0032009"(early phagosome)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032717"(negative regulation of interleukin-8 production)|go:"GO:0005789"(endoplasmic reticulum membrane)|rcsb pdb:4QDH|rcsb pdb:5ZLN|reactome:R-MMU-109704|reactome:R-MMU-1679131|reactome:R-MMU-168138|go:"GO:1901895"(negative regulation of ATPase-coupled calcium transmembrane transporter activity)|go:"GO:1902350"(cellular response to chloroquine)|interpro:IPR000157(Toll-Interleukin receptor)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR027181|interpro:IPR035897|interpro:IPR041283|mint:Q9EQU3|rcsb pdb:3WPF|rcsb pdb:3WPG|rcsb pdb:3WPH|rcsb pdb:3WPI|go:"GO:0032725"(positive regulation of granulocyte macrophage colony-stimulating factor production)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032741"(positive regulation of interleukin-18 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0034122"(negative regulation of toll-like receptor signaling pathway)|go:"GO:0034123"(positive regulation of toll-like receptor signaling pathway)|go:"GO:0034162"(toll-like receptor 9 signaling pathway)|go:"GO:0034163"(regulation of toll-like receptor 9 signaling pathway)|go:"GO:0034165"(positive regulation of toll-like receptor 9 signaling pathway)|go:"GO:0035197"(siRNA binding)|go:"GO:0036019"(endolysosome)|go:"GO:0038187"(pattern recognition receptor activity)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0032722"(positive regulation of chemokine production)	rgd:2266|refseq:NP_742005.1|refseq:XP_008765901.1|refseq:XP_008765902.1|ensembl:ENSRNOG00000003343(gene)|ensembl:ENSRNOT00000049942(transcript)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005840"(ribosome)|go:"GO:0006457"(protein folding)|go:"GO:0007568"(aging)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0030424"(axon)|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034185"(apolipoprotein binding)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0042470"(melanosome)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0044233"(mitochondria-associated endoplasmic reticulum membrane)|go:"GO:0044322"(endoplasmic reticulum quality control compartment)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0072583"(clathrin-dependent endocytosis)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099059"(integral component of presynaptic active zone membrane)|interpro:IPR001580(Calreticulin/calnexin)|interpro:IPR009033(Calreticulin/calnexin, P)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR018124|mint:P35565|reactome:R-RNO-2132295|reactome:R-RNO-901042|reactome:R-RNO-9020956|reactome:R-RNO-983170	-	-	-	figure legend:sf1b f1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat-cardiac_myocytes)|taxid:10116(rat cardiac myocytes)	-	2014/11/18	2014/11/18	rogid:3XKXj7PkEGE5qOchJfjMHFREkT010090	rogid:OA7gJ6oMBN6zraU38Xg856XebR810116	intact-crc:70A3FF53549AB406|rigid:8b0W4ZmSLQHpG6EH8YyUNdlAlZE	false	calmodulin binding peptide plus protein a tag:c-c	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9EQU3	uniprotkb:P06761	intact:EBI-9979528|ensembl:ENSMUSP00000082207|uniprotkb:F8VPN5|uniprotkb:Q4L0K3|uniprotkb:Q4L0K4|uniprotkb:Q99MF2|uniprotkb:Q99MQ8	intact:EBI-916036|ensembl:ENSRNOP00000025064	psi-mi:tlr9_mouse(display_long)|uniprotkb:Tlr9(gene name)|psi-mi:Tlr9(display_short)	psi-mi:bip_rat(display_long)|uniprotkb:Hspa5(gene name)|psi-mi:Hspa5(display_short)|uniprotkb:Grp78(gene name synonym)|uniprotkb:Immunoglobulin heavy chain-binding protein(gene name synonym)|uniprotkb:Steroidogenesis-activator polypeptide(gene name synonym)|uniprotkb:78 kDa glucose-regulated protein(gene name synonym)|uniprotkb:Binding-immunoglobulin protein(gene name synonym)|uniprotkb:Heat shock protein 70 family protein 5(gene name synonym)|uniprotkb:Heat shock protein family A member 5(gene name synonym)	psi-mi:"MI:0676"(tandem affinity purification)	Shintani et al. (2014)	imex:IM-23524|pubmed:24610369	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-9979511|imex:IM-23524-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000045322(gene)|ensembl:ENSMUST00000062241(transcript)|go:"GO:0001774"(microglial cell activation)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0002224"(toll-like receptor signaling pathway)|go:"GO:0002237"(response to molecule of bacterial origin)|go:"GO:0002639"(positive regulation of immunoglobulin production)|go:"GO:0002730"(regulation of dendritic cell cytokine production)|go:"GO:0002755"(MyD88-dependent toll-like receptor signaling pathway)|go:"GO:0005149"(interleukin-1 receptor binding)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|refseq:NP_112455.2|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0045087"(innate immune response)|go:"GO:0045322"(unmethylated CpG binding)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0045577"(regulation of B cell differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0050864"(regulation of B cell activation)|go:"GO:0050871"(positive regulation of B cell activation)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051607"(defense response to virus)|go:"GO:0051770"(positive regulation of nitric-oxide synthase biosynthetic process)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071248"(cellular response to metal ion)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:0005886"(plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0007252"(I-kappaB phosphorylation)|go:"GO:0008584"(male gonad development)|go:"GO:0009615"(response to virus)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030277"(maintenance of gastrointestinal epithelium)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0032009"(early phagosome)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032717"(negative regulation of interleukin-8 production)|go:"GO:0005789"(endoplasmic reticulum membrane)|rcsb pdb:4QDH|rcsb pdb:5ZLN|reactome:R-MMU-109704|reactome:R-MMU-1679131|reactome:R-MMU-168138|go:"GO:1901895"(negative regulation of ATPase-coupled calcium transmembrane transporter activity)|go:"GO:1902350"(cellular response to chloroquine)|interpro:IPR000157(Toll-Interleukin receptor)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR027181|interpro:IPR035897|interpro:IPR041283|mint:Q9EQU3|rcsb pdb:3WPF|rcsb pdb:3WPG|rcsb pdb:3WPH|rcsb pdb:3WPI|go:"GO:0032725"(positive regulation of granulocyte macrophage colony-stimulating factor production)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032741"(positive regulation of interleukin-18 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0034122"(negative regulation of toll-like receptor signaling pathway)|go:"GO:0034123"(positive regulation of toll-like receptor signaling pathway)|go:"GO:0034162"(toll-like receptor 9 signaling pathway)|go:"GO:0034163"(regulation of toll-like receptor 9 signaling pathway)|go:"GO:0034165"(positive regulation of toll-like receptor 9 signaling pathway)|go:"GO:0035197"(siRNA binding)|go:"GO:0036019"(endolysosome)|go:"GO:0038187"(pattern recognition receptor activity)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0032722"(positive regulation of chemokine production)	rgd:2843|refseq:NP_037215.1|ensembl:ENSRNOG00000018294(gene)|ensembl:ENSRNOT00000025067(transcript)|go:"GO:0001554"(luteolysis)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006983"(ER overload response)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0009314"(response to radiation)|go:"GO:0009986"(cell surface)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0016020"(membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0021589"(cerebellum structural organization)|go:"GO:0021680"(cerebellar Purkinje cell layer development)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030496"(midbody)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031204"(posttranslational protein targeting to membrane, translocation)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034620"(cellular response to unfolded protein)|go:"GO:0034663"(endoplasmic reticulum chaperone complex)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035437"(maintenance of protein localization in endoplasmic reticulum)|go:"GO:0035690"|go:"GO:0036498"(IRE1-mediated unfolded protein response)|go:"GO:0042026"(protein refolding)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0042220"(response to cocaine)|go:"GO:0043022"(ribosome binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0051603"(proteolysis involved in cellular protein catabolic process)|go:"GO:0051787"(misfolded protein binding)|go:"GO:0071236"(cellular response to antibiotic)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0071287"(cellular response to manganese ion)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071353"(cellular response to interleukin-4)|go:"GO:0071480"(cellular response to gamma radiation)|go:"GO:0097501"(stress response to metal ion)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1901998"(toxin transport)|go:"GO:1903895"(negative regulation of IRE1-mediated unfolded protein response)|go:"GO:1904313"(response to methamphetamine hydrochloride)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|interpro:IPR013126(Heat shock protein 70)|interpro:IPR018181|interpro:IPR029047|interpro:IPR029048|interpro:IPR042050|interpro:IPR043129|mint:P06761|reactome:R-RNO-3371453|reactome:R-RNO-983170	-	-	-	figure legend:sf1b f1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat-cardiac_myocytes)|taxid:10116(rat cardiac myocytes)	-	2014/11/18	2014/11/18	rogid:3XKXj7PkEGE5qOchJfjMHFREkT010090	rogid:5HRXkoNHYJvBA2iejRqltGRdJDw10116	intact-crc:70A3FF53549AB406|rigid:8b0W4ZmSLQHpG6EH8YyUNdlAlZE	false	calmodulin binding peptide plus protein a tag:c-c	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9EQU3	uniprotkb:P41123	intact:EBI-9979528|ensembl:ENSMUSP00000082207|uniprotkb:F8VPN5|uniprotkb:Q4L0K3|uniprotkb:Q4L0K4|uniprotkb:Q99MF2|uniprotkb:Q99MQ8	intact:EBI-917471|ensembl:ENSRNOP00000020635	psi-mi:tlr9_mouse(display_long)|uniprotkb:Tlr9(gene name)|psi-mi:Tlr9(display_short)	psi-mi:rl13_rat(display_long)|uniprotkb:Rpl13(gene name)|psi-mi:Rpl13(display_short)	psi-mi:"MI:0676"(tandem affinity purification)	Shintani et al. (2014)	imex:IM-23524|pubmed:24610369	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-9979511|imex:IM-23524-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000045322(gene)|ensembl:ENSMUST00000062241(transcript)|go:"GO:0001774"(microglial cell activation)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0002224"(toll-like receptor signaling pathway)|go:"GO:0002237"(response to molecule of bacterial origin)|go:"GO:0002639"(positive regulation of immunoglobulin production)|go:"GO:0002730"(regulation of dendritic cell cytokine production)|go:"GO:0002755"(MyD88-dependent toll-like receptor signaling pathway)|go:"GO:0005149"(interleukin-1 receptor binding)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|refseq:NP_112455.2|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0045087"(innate immune response)|go:"GO:0045322"(unmethylated CpG binding)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0045577"(regulation of B cell differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0050864"(regulation of B cell activation)|go:"GO:0050871"(positive regulation of B cell activation)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051607"(defense response to virus)|go:"GO:0051770"(positive regulation of nitric-oxide synthase biosynthetic process)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071248"(cellular response to metal ion)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:0005886"(plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0007252"(I-kappaB phosphorylation)|go:"GO:0008584"(male gonad development)|go:"GO:0009615"(response to virus)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030277"(maintenance of gastrointestinal epithelium)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0032009"(early phagosome)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032717"(negative regulation of interleukin-8 production)|go:"GO:0005789"(endoplasmic reticulum membrane)|rcsb pdb:4QDH|rcsb pdb:5ZLN|reactome:R-MMU-109704|reactome:R-MMU-1679131|reactome:R-MMU-168138|go:"GO:1901895"(negative regulation of ATPase-coupled calcium transmembrane transporter activity)|go:"GO:1902350"(cellular response to chloroquine)|interpro:IPR000157(Toll-Interleukin receptor)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR027181|interpro:IPR035897|interpro:IPR041283|mint:Q9EQU3|rcsb pdb:3WPF|rcsb pdb:3WPG|rcsb pdb:3WPH|rcsb pdb:3WPI|go:"GO:0032725"(positive regulation of granulocyte macrophage colony-stimulating factor production)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032741"(positive regulation of interleukin-18 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0034122"(negative regulation of toll-like receptor signaling pathway)|go:"GO:0034123"(positive regulation of toll-like receptor signaling pathway)|go:"GO:0034162"(toll-like receptor 9 signaling pathway)|go:"GO:0034163"(regulation of toll-like receptor 9 signaling pathway)|go:"GO:0034165"(positive regulation of toll-like receptor 9 signaling pathway)|go:"GO:0035197"(siRNA binding)|go:"GO:0036019"(endolysosome)|go:"GO:0038187"(pattern recognition receptor activity)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0032722"(positive regulation of chemokine production)	rgd:621179|refseq:NP_112363.1|ensembl:ENSRNOG00000015335(gene)|ensembl:ENSRNOT00000020635(transcript)|go:"GO:0001824"(blastocyst development)|go:"GO:0003723"(RNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0006412"(translation)|go:"GO:0022625"(cytosolic large ribosomal subunit)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0060348"(bone development)|go:"GO:0097421"(liver regeneration)|interpro:IPR001380(Ribosomal protein L13e)|interpro:IPR018256|mint:P41123|reactome:R-RNO-156827|reactome:R-RNO-1799339|reactome:R-RNO-6791226|reactome:R-RNO-72689|reactome:R-RNO-72706|reactome:R-RNO-975956|reactome:R-RNO-975957	-	-	-	figure legend:sf1b f1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat-cardiac_myocytes)|taxid:10116(rat cardiac myocytes)	-	2014/11/18	2014/11/18	rogid:3XKXj7PkEGE5qOchJfjMHFREkT010090	rogid:VaQ1k6Ys24FJswxJBjygrPBW8JE10116	intact-crc:70A3FF53549AB406|rigid:8b0W4ZmSLQHpG6EH8YyUNdlAlZE	false	calmodulin binding peptide plus protein a tag:c-c	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9EQU3	uniprotkb:Q63429	intact:EBI-9979528|ensembl:ENSMUSP00000082207|uniprotkb:F8VPN5|uniprotkb:Q4L0K3|uniprotkb:Q4L0K4|uniprotkb:Q99MF2|uniprotkb:Q99MQ8	intact:EBI-9979469|uniprotkb:Q3ZBA1	psi-mi:tlr9_mouse(display_long)|uniprotkb:Tlr9(gene name)|psi-mi:Tlr9(display_short)	psi-mi:ubc_rat(display_long)|uniprotkb:Ubc(gene name)|psi-mi:Ubc(display_short)	psi-mi:"MI:0676"(tandem affinity purification)	Shintani et al. (2014)	imex:IM-23524|pubmed:24610369	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-9979511|imex:IM-23524-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000045322(gene)|ensembl:ENSMUST00000062241(transcript)|go:"GO:0001774"(microglial cell activation)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0002224"(toll-like receptor signaling pathway)|go:"GO:0002237"(response to molecule of bacterial origin)|go:"GO:0002639"(positive regulation of immunoglobulin production)|go:"GO:0002730"(regulation of dendritic cell cytokine production)|go:"GO:0002755"(MyD88-dependent toll-like receptor signaling pathway)|go:"GO:0005149"(interleukin-1 receptor binding)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|refseq:NP_112455.2|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0045087"(innate immune response)|go:"GO:0045322"(unmethylated CpG binding)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0045577"(regulation of B cell differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0050864"(regulation of B cell activation)|go:"GO:0050871"(positive regulation of B cell activation)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051607"(defense response to virus)|go:"GO:0051770"(positive regulation of nitric-oxide synthase biosynthetic process)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071248"(cellular response to metal ion)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:0005886"(plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0007252"(I-kappaB phosphorylation)|go:"GO:0008584"(male gonad development)|go:"GO:0009615"(response to virus)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030277"(maintenance of gastrointestinal epithelium)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0032009"(early phagosome)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032717"(negative regulation of interleukin-8 production)|go:"GO:0005789"(endoplasmic reticulum membrane)|rcsb pdb:4QDH|rcsb pdb:5ZLN|reactome:R-MMU-109704|reactome:R-MMU-1679131|reactome:R-MMU-168138|go:"GO:1901895"(negative regulation of ATPase-coupled calcium transmembrane transporter activity)|go:"GO:1902350"(cellular response to chloroquine)|interpro:IPR000157(Toll-Interleukin receptor)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR027181|interpro:IPR035897|interpro:IPR041283|mint:Q9EQU3|rcsb pdb:3WPF|rcsb pdb:3WPG|rcsb pdb:3WPH|rcsb pdb:3WPI|go:"GO:0032725"(positive regulation of granulocyte macrophage colony-stimulating factor production)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032741"(positive regulation of interleukin-18 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0034122"(negative regulation of toll-like receptor signaling pathway)|go:"GO:0034123"(positive regulation of toll-like receptor signaling pathway)|go:"GO:0034162"(toll-like receptor 9 signaling pathway)|go:"GO:0034163"(regulation of toll-like receptor 9 signaling pathway)|go:"GO:0034165"(positive regulation of toll-like receptor 9 signaling pathway)|go:"GO:0035197"(siRNA binding)|go:"GO:0036019"(endolysosome)|go:"GO:0038187"(pattern recognition receptor activity)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0032722"(positive regulation of chemokine production)	reactome:R-RNO-168638|reactome:R-RNO-174048|reactome:R-RNO-174084|reactome:R-RNO-174154|reactome:R-RNO-174178|reactome:R-RNO-174184|reactome:R-RNO-179409|reactome:R-RNO-182971|reactome:R-RNO-187577|reactome:R-RNO-195253|reactome:R-RNO-201681|reactome:R-RNO-205043|reactome:R-RNO-209543|reactome:R-RNO-209560|reactome:R-RNO-2122948|reactome:R-RNO-2173788|reactome:R-RNO-2173791|reactome:R-RNO-2173795|reactome:R-RNO-2173796|reactome:R-RNO-2467813|reactome:R-RNO-1358803|go:"GO:0002020"(protease binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019941"(modification-dependent protein catabolic process)|go:"GO:0031386"(protein tag)|go:"GO:0031625"(ubiquitin protein ligase binding)|rcsb pdb:5L9U|reactome:R-RNO-110312|reactome:R-RNO-110314|reactome:R-RNO-110320|reactome:R-RNO-1169091|reactome:R-RNO-1234176|reactome:R-RNO-1253288|reactome:R-RNO-1295596|reactome:R-RNO-5610785|reactome:R-RNO-5632684|reactome:R-RNO-5654726|reactome:R-RNO-532668|reactome:R-RNO-2559580|reactome:R-RNO-2559582|reactome:R-RNO-2559585|reactome:R-RNO-2565942|reactome:R-RNO-2672351|reactome:R-RNO-3134975|reactome:R-RNO-349425|reactome:R-RNO-3769402|reactome:R-RNO-382556|reactome:R-RNO-445989|reactome:R-RNO-450302|reactome:R-RNO-450321|reactome:R-RNO-450408|reactome:R-RNO-5357905|reactome:R-RNO-5357956|reactome:R-RNO-4608870|reactome:R-RNO-4641257|reactome:R-RNO-4641258|reactome:R-RNO-4641263|reactome:R-RNO-5358346|reactome:R-RNO-5607761|reactome:R-RNO-5610780|reactome:R-RNO-9664873|reactome:R-RNO-9705462|reactome:R-RNO-9706369|reactome:R-RNO-975163|reactome:R-RNO-983168|reactome:R-RNO-9648002|reactome:R-RNO-5654732|reactome:R-RNO-5654727|reactome:R-RNO-5654733|reactome:R-RNO-5655862|reactome:R-RNO-5656121|reactome:R-RNO-5656169|reactome:R-RNO-5658442|reactome:R-RNO-5668541|reactome:R-RNO-5675221|reactome:R-RNO-5675482|reactome:R-RNO-5676590|reactome:R-RNO-5685942|reactome:R-RNO-5687128|reactome:R-RNO-5689603|reactome:R-RNO-5689877|reactome:R-RNO-5689880|reactome:R-RNO-5689896|reactome:R-RNO-5689901|reactome:R-RNO-5693565|reactome:R-RNO-5696394|reactome:R-RNO-5696395|reactome:R-RNO-5696397|reactome:R-RNO-5696400|reactome:R-RNO-6781823|reactome:R-RNO-6782135|reactome:R-RNO-6782210|reactome:R-RNO-6783310|reactome:R-RNO-6804756|reactome:R-RNO-6804757|reactome:R-RNO-6804760|reactome:R-RNO-6807004|reactome:R-RNO-68827|reactome:R-RNO-68949|reactome:R-RNO-69017|reactome:R-RNO-69231|reactome:R-RNO-69481|reactome:R-RNO-69541|reactome:R-RNO-69601|reactome:R-RNO-75815|reactome:R-RNO-8849469|reactome:R-RNO-8852276|reactome:R-RNO-8854050|reactome:R-RNO-8856825|reactome:R-RNO-8863795|reactome:R-RNO-8866652|reactome:R-RNO-8856828|reactome:R-RNO-8866654|reactome:R-RNO-8932339|reactome:R-RNO-8939236|reactome:R-RNO-8941858|reactome:R-RNO-8948747|reactome:R-RNO-8948751|reactome:R-RNO-8951664|reactome:R-RNO-901032|reactome:R-RNO-9013507|reactome:R-RNO-9020702|reactome:R-RNO-9033241|reactome:R-RNO-912631|reactome:R-RNO-917729|reactome:R-RNO-917937|reactome:R-RNO-937042|reactome:R-RNO-937072|reactome:R-RNO-9645460|reactome:R-RNO-9646399|refseq:NP_059010.1|interpro:IPR019956|interpro:IPR000626(Ubiquitin)|interpro:IPR029071|interpro:IPR019954|rgd:621244|mint:Q63429	-	-	-	figure legend:sf1b f1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat-cardiac_myocytes)|taxid:10116(rat cardiac myocytes)	-	2014/11/18	2014/11/18	rogid:3XKXj7PkEGE5qOchJfjMHFREkT010090	rogid:9QQbp2rY1QHl68DhN4zYQMPXuZ410116	intact-crc:70A3FF53549AB406|rigid:8b0W4ZmSLQHpG6EH8YyUNdlAlZE	false	calmodulin binding peptide plus protein a tag:c-c	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9EQU3	uniprotkb:Q06647	intact:EBI-9979528|ensembl:ENSMUSP00000082207|uniprotkb:F8VPN5|uniprotkb:Q4L0K3|uniprotkb:Q4L0K4|uniprotkb:Q99MF2|uniprotkb:Q99MQ8	intact:EBI-918179|ensembl:ENSRNOP00000002732	psi-mi:tlr9_mouse(display_long)|uniprotkb:Tlr9(gene name)|psi-mi:Tlr9(display_short)	psi-mi:atpo_rat(display_long)|uniprotkb:Atp5po(gene name)|psi-mi:Atp5po(display_short)|uniprotkb:ATP synthase peripheral stalk subunit OSCP(gene name synonym)|uniprotkb:Atp5o(gene name synonym)|uniprotkb:Oligomycin sensitivity conferral protein(gene name synonym)|uniprotkb:Sperm flagella protein 4(gene name synonym)	psi-mi:"MI:0676"(tandem affinity purification)	Shintani et al. (2014)	imex:IM-23524|pubmed:24610369	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-9979511|imex:IM-23524-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000045322(gene)|ensembl:ENSMUST00000062241(transcript)|go:"GO:0001774"(microglial cell activation)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0002224"(toll-like receptor signaling pathway)|go:"GO:0002237"(response to molecule of bacterial origin)|go:"GO:0002639"(positive regulation of immunoglobulin production)|go:"GO:0002730"(regulation of dendritic cell cytokine production)|go:"GO:0002755"(MyD88-dependent toll-like receptor signaling pathway)|go:"GO:0005149"(interleukin-1 receptor binding)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|refseq:NP_112455.2|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0045087"(innate immune response)|go:"GO:0045322"(unmethylated CpG binding)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0045577"(regulation of B cell differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0050864"(regulation of B cell activation)|go:"GO:0050871"(positive regulation of B cell activation)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051607"(defense response to virus)|go:"GO:0051770"(positive regulation of nitric-oxide synthase biosynthetic process)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071248"(cellular response to metal ion)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:0005886"(plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0007252"(I-kappaB phosphorylation)|go:"GO:0008584"(male gonad development)|go:"GO:0009615"(response to virus)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030277"(maintenance of gastrointestinal epithelium)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0032009"(early phagosome)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032717"(negative regulation of interleukin-8 production)|go:"GO:0005789"(endoplasmic reticulum membrane)|rcsb pdb:4QDH|rcsb pdb:5ZLN|reactome:R-MMU-109704|reactome:R-MMU-1679131|reactome:R-MMU-168138|go:"GO:1901895"(negative regulation of ATPase-coupled calcium transmembrane transporter activity)|go:"GO:1902350"(cellular response to chloroquine)|interpro:IPR000157(Toll-Interleukin receptor)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR027181|interpro:IPR035897|interpro:IPR041283|mint:Q9EQU3|rcsb pdb:3WPF|rcsb pdb:3WPG|rcsb pdb:3WPH|rcsb pdb:3WPI|go:"GO:0032725"(positive regulation of granulocyte macrophage colony-stimulating factor production)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032741"(positive regulation of interleukin-18 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0034122"(negative regulation of toll-like receptor signaling pathway)|go:"GO:0034123"(positive regulation of toll-like receptor signaling pathway)|go:"GO:0034162"(toll-like receptor 9 signaling pathway)|go:"GO:0034163"(regulation of toll-like receptor 9 signaling pathway)|go:"GO:0034165"(positive regulation of toll-like receptor 9 signaling pathway)|go:"GO:0035197"(siRNA binding)|go:"GO:0036019"(endolysosome)|go:"GO:0038187"(pattern recognition receptor activity)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0032722"(positive regulation of chemokine production)	rgd:621379|refseq:NP_620238.1|ensembl:ENSRNOG00000001991(gene)|ensembl:ENSRNOT00000002732(transcript)|go:"GO:0000274"(mitochondrial proton-transporting ATP synthase, stator stalk)|go:"GO:0000276"("mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)")|go:"GO:0005739"(mitochondrion)|go:"GO:0005753"(mitochondrial proton-transporting ATP synthase complex)|go:"GO:0005886"(plasma membrane)|go:"GO:0006754"(ATP biosynthetic process)|go:"GO:0009986"(cell surface)|go:"GO:0015986"(ATP synthesis coupled proton transport)|go:"GO:0042776"(mitochondrial ATP synthesis coupled proton transport)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045261"("proton-transporting ATP synthase complex, catalytic core F(1)")|go:"GO:0046034"(ATP metabolic process)|go:"GO:0046933"(proton-transporting ATP synthase activity, rotational mechanism)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:1903924"(estradiol binding)|interpro:IPR000711(ATPase, F1 complex, OSCP/delta subunit)|interpro:IPR020781|interpro:IPR026015|mint:Q06647|reactome:R-RNO-163210|reactome:R-RNO-8949613	-	-	-	figure legend:sf1b f1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat-cardiac_myocytes)|taxid:10116(rat cardiac myocytes)	-	2014/11/18	2014/11/18	rogid:3XKXj7PkEGE5qOchJfjMHFREkT010090	rogid:F/PihaxUf1uclL8LOwKpSse+dCA10116	intact-crc:70A3FF53549AB406|rigid:8b0W4ZmSLQHpG6EH8YyUNdlAlZE	false	calmodulin binding peptide plus protein a tag:c-c	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9EQU3	uniprotkb:P11507	intact:EBI-9979528|ensembl:ENSMUSP00000082207|uniprotkb:F8VPN5|uniprotkb:Q4L0K3|uniprotkb:Q4L0K4|uniprotkb:Q99MF2|uniprotkb:Q99MQ8	intact:EBI-916319|uniprotkb:P11508|ensembl:ENSRNOP00000024347	psi-mi:tlr9_mouse(display_long)|uniprotkb:Tlr9(gene name)|psi-mi:Tlr9(display_short)	psi-mi:at2a2_rat(display_long)|uniprotkb:Calcium pump 2(gene name synonym)|uniprotkb:Calcium-transporting ATPase sarcoplasmic reticulum type, slow twitch skeletal muscle isoform(gene name synonym)|uniprotkb:"Endoplasmic reticulum class 1/2 Ca(2+) ATPase"(gene name synonym)|uniprotkb:Atp2a2(gene name)|psi-mi:Atp2a2(display_short)	psi-mi:"MI:0676"(tandem affinity purification)	Shintani et al. (2014)	imex:IM-23524|pubmed:24610369	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-9979511|imex:IM-23524-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000045322(gene)|ensembl:ENSMUST00000062241(transcript)|go:"GO:0001774"(microglial cell activation)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0002224"(toll-like receptor signaling pathway)|go:"GO:0002237"(response to molecule of bacterial origin)|go:"GO:0002639"(positive regulation of immunoglobulin production)|go:"GO:0002730"(regulation of dendritic cell cytokine production)|go:"GO:0002755"(MyD88-dependent toll-like receptor signaling pathway)|go:"GO:0005149"(interleukin-1 receptor binding)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|refseq:NP_112455.2|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0045087"(innate immune response)|go:"GO:0045322"(unmethylated CpG binding)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0045577"(regulation of B cell differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0050864"(regulation of B cell activation)|go:"GO:0050871"(positive regulation of B cell activation)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051607"(defense response to virus)|go:"GO:0051770"(positive regulation of nitric-oxide synthase biosynthetic process)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071248"(cellular response to metal ion)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:0005886"(plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0007252"(I-kappaB phosphorylation)|go:"GO:0008584"(male gonad development)|go:"GO:0009615"(response to virus)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030277"(maintenance of gastrointestinal epithelium)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0032009"(early phagosome)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032717"(negative regulation of interleukin-8 production)|go:"GO:0005789"(endoplasmic reticulum membrane)|rcsb pdb:4QDH|rcsb pdb:5ZLN|reactome:R-MMU-109704|reactome:R-MMU-1679131|reactome:R-MMU-168138|go:"GO:1901895"(negative regulation of ATPase-coupled calcium transmembrane transporter activity)|go:"GO:1902350"(cellular response to chloroquine)|interpro:IPR000157(Toll-Interleukin receptor)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR027181|interpro:IPR035897|interpro:IPR041283|mint:Q9EQU3|rcsb pdb:3WPF|rcsb pdb:3WPG|rcsb pdb:3WPH|rcsb pdb:3WPI|go:"GO:0032725"(positive regulation of granulocyte macrophage colony-stimulating factor production)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032741"(positive regulation of interleukin-18 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0034122"(negative regulation of toll-like receptor signaling pathway)|go:"GO:0034123"(positive regulation of toll-like receptor signaling pathway)|go:"GO:0034162"(toll-like receptor 9 signaling pathway)|go:"GO:0034163"(regulation of toll-like receptor 9 signaling pathway)|go:"GO:0034165"(positive regulation of toll-like receptor 9 signaling pathway)|go:"GO:0035197"(siRNA binding)|go:"GO:0036019"(endolysosome)|go:"GO:0038187"(pattern recognition receptor activity)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0032722"(positive regulation of chemokine production)	ensembl:ENSRNOG00000001285(gene)|ensembl:ENSRNOT00000024347(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0002026"(regulation of the force of heart contraction)|go:"GO:0003009"(skeletal muscle contraction)|go:"GO:0005388"(P-type calcium transporter activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006937"(regulation of muscle contraction)|go:"GO:0006984"(ER-nucleus signaling pathway)|go:"GO:0006996"(organelle organization)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008553"(P-type proton-exporting transporter activity)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0012506"(vesicle membrane)|go:"GO:0014883"(transition between fast and slow fiber)|go:"GO:0120025"(plasma membrane bounded cell projection)|go:"GO:0140056"(organelle localization by membrane tethering)|go:"GO:1900121"(negative regulation of receptor binding)|go:"GO:1903233"(regulation of calcium ion-dependent exocytosis of neurotransmitter)|go:"GO:1903515"(calcium ion transport from cytosol to endoplasmic reticulum)|go:"GO:1990036"(calcium ion import into sarcoplasmic reticulum)|go:"GO:1990456"(mitochondrion-endoplasmic reticulum membrane tethering)|interpro:IPR001757(ATPase, P-type, K/Mg/Cd/Cu/Zn/Na/Ca/Na/H-transporter)|interpro:IPR004014(ATPase, P-type cation-transporter, N-terminal)|interpro:IPR005782(Calcium ATPase)|interpro:IPR006068(ATPase, P-type cation-transporter, C-terminal)|interpro:IPR008250(E1-E2 ATPase-associated region)|interpro:IPR018303|interpro:IPR023214|interpro:IPR023298|interpro:IPR023299|interpro:IPR036412|interpro:IPR044492|mint:P11507|reactome:R-RNO-418359|reactome:R-RNO-5578775|reactome:R-RNO-936837|go:"GO:0014898"(cardiac muscle hypertrophy in response to stress)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016240"(autophagosome membrane docking)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0019899"(enzyme binding)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031775"(lutropin-choriogonadotropic hormone receptor binding)|go:"GO:0032469"(endoplasmic reticulum calcium ion homeostasis)|go:"GO:0032470"(positive regulation of endoplasmic reticulum calcium ion concentration)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033017"(sarcoplasmic reticulum membrane)|go:"GO:0033292"(T-tubule organization)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0034605"(cellular response to heat)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044548"(S100 protein binding)|go:"GO:0045822"(negative regulation of heart contraction)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0055119"(relaxation of cardiac muscle)|go:"GO:0061831"(apical ectoplasmic specialization)|go:"GO:0070296"(sarcoplasmic reticulum calcium ion transport)|go:"GO:0070588"(calcium ion transmembrane transport)|go:"GO:0086036"(regulation of cardiac muscle cell membrane potential)|go:"GO:0086039"(P-type calcium transporter activity involved in regulation of cardiac muscle cell membrane potential)|go:"GO:0097470"(ribbon synapse)|go:"GO:0098909"(regulation of cardiac muscle cell action potential involved in regulation of contraction)|rgd:2174|refseq:NP_001103609.1|refseq:NP_001104293.1	-	-	-	figure legend:sf1b f1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat-cardiac_myocytes)|taxid:10116(rat cardiac myocytes)	-	2014/11/18	2014/11/18	rogid:3XKXj7PkEGE5qOchJfjMHFREkT010090	rogid:Et/ot4KEtlnq8iuoVL0CySJICIo10116	intact-crc:70A3FF53549AB406|rigid:8b0W4ZmSLQHpG6EH8YyUNdlAlZE	false	calmodulin binding peptide plus protein a tag:c-c	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9EQU3	uniprotkb:P42930	intact:EBI-9979528|ensembl:ENSMUSP00000082207|uniprotkb:F8VPN5|uniprotkb:Q4L0K3|uniprotkb:Q4L0K4|uniprotkb:Q99MF2|uniprotkb:Q99MQ8	intact:EBI-917489|uniprotkb:Q63922|uniprotkb:Q9QWA8	psi-mi:tlr9_mouse(display_long)|uniprotkb:Tlr9(gene name)|psi-mi:Tlr9(display_short)	psi-mi:hspb1_rat(display_long)|uniprotkb:Heat shock 27 kDa protein(gene name synonym)|uniprotkb:Hspb1(gene name)|psi-mi:Hspb1(display_short)|uniprotkb:Hsp27(gene name synonym)	psi-mi:"MI:0676"(tandem affinity purification)	Shintani et al. (2014)	imex:IM-23524|pubmed:24610369	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-9979511|imex:IM-23524-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000045322(gene)|ensembl:ENSMUST00000062241(transcript)|go:"GO:0001774"(microglial cell activation)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0002224"(toll-like receptor signaling pathway)|go:"GO:0002237"(response to molecule of bacterial origin)|go:"GO:0002639"(positive regulation of immunoglobulin production)|go:"GO:0002730"(regulation of dendritic cell cytokine production)|go:"GO:0002755"(MyD88-dependent toll-like receptor signaling pathway)|go:"GO:0005149"(interleukin-1 receptor binding)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|refseq:NP_112455.2|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0045087"(innate immune response)|go:"GO:0045322"(unmethylated CpG binding)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0045577"(regulation of B cell differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0050864"(regulation of B cell activation)|go:"GO:0050871"(positive regulation of B cell activation)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051607"(defense response to virus)|go:"GO:0051770"(positive regulation of nitric-oxide synthase biosynthetic process)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071248"(cellular response to metal ion)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:0005886"(plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0007252"(I-kappaB phosphorylation)|go:"GO:0008584"(male gonad development)|go:"GO:0009615"(response to virus)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030277"(maintenance of gastrointestinal epithelium)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0032009"(early phagosome)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032717"(negative regulation of interleukin-8 production)|go:"GO:0005789"(endoplasmic reticulum membrane)|rcsb pdb:4QDH|rcsb pdb:5ZLN|reactome:R-MMU-109704|reactome:R-MMU-1679131|reactome:R-MMU-168138|go:"GO:1901895"(negative regulation of ATPase-coupled calcium transmembrane transporter activity)|go:"GO:1902350"(cellular response to chloroquine)|interpro:IPR000157(Toll-Interleukin receptor)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR027181|interpro:IPR035897|interpro:IPR041283|mint:Q9EQU3|rcsb pdb:3WPF|rcsb pdb:3WPG|rcsb pdb:3WPH|rcsb pdb:3WPI|go:"GO:0032725"(positive regulation of granulocyte macrophage colony-stimulating factor production)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032741"(positive regulation of interleukin-18 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0034122"(negative regulation of toll-like receptor signaling pathway)|go:"GO:0034123"(positive regulation of toll-like receptor signaling pathway)|go:"GO:0034162"(toll-like receptor 9 signaling pathway)|go:"GO:0034163"(regulation of toll-like receptor 9 signaling pathway)|go:"GO:0034165"(positive regulation of toll-like receptor 9 signaling pathway)|go:"GO:0035197"(siRNA binding)|go:"GO:0036019"(endolysosome)|go:"GO:0038187"(pattern recognition receptor activity)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0032722"(positive regulation of chemokine production)	rgd:61306|interpro:IPR001436(Alpha crystallin/Heat shock protein)|interpro:IPR002068(Heat shock protein Hsp20)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR037876|mint:P42930|go:"GO:0000502"(proteasome complex)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0002931"(response to ischemia)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005819"(spindle)|go:"GO:0005886"(plasma membrane)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0007565"(female pregnancy)|go:"GO:0007568"(aging)|go:"GO:0008426"(protein kinase C inhibitor activity)|go:"GO:0009615"(response to virus)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030018"(Z disc)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031430"(M band)|go:"GO:0031674"(I band)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|go:"GO:0035994"(response to muscle stretch)|go:"GO:0038033"(positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043292"(contractile fiber)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0045202"(synapse)|go:"GO:0045590"(negative regulation of regulatory T cell differentiation)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0061077"(chaperone-mediated protein folding)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0071348"(cellular response to interleukin-11)|go:"GO:0097512"(cardiac myofibril)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0099641"(anterograde axonal protein transport)|go:"GO:1902176"(negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1903202"(negative regulation of oxidative stress-induced cell death)|go:"GO:1903545"(cellular response to butyrate)|go:"GO:1904115"(axon cytoplasm)|go:"GO:1990776"(response to angiotensin)|go:"GO:2001028"(positive regulation of endothelial cell chemotaxis)|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|reactome:R-RNO-4420097|reactome:R-RNO-450408|reactome:R-RNO-5687128|reactome:R-RNO-9009391	-	-	-	figure legend:sf1b f1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat-cardiac_myocytes)|taxid:10116(rat cardiac myocytes)	-	2014/11/18	2014/11/18	rogid:3XKXj7PkEGE5qOchJfjMHFREkT010090	rogid:4VkGr8nFFRoQa+1RiEto9b3gIv410116	intact-crc:70A3FF53549AB406|rigid:8b0W4ZmSLQHpG6EH8YyUNdlAlZE	false	calmodulin binding peptide plus protein a tag:c-c	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)
uniprotkb:Q9EQU3	uniprotkb:P11507	intact:EBI-9979528|ensembl:ENSMUSP00000082207|uniprotkb:F8VPN5|uniprotkb:Q4L0K3|uniprotkb:Q4L0K4|uniprotkb:Q99MF2|uniprotkb:Q99MQ8	intact:EBI-916319|uniprotkb:P11508|ensembl:ENSRNOP00000024347	psi-mi:tlr9_mouse(display_long)|uniprotkb:Tlr9(gene name)|psi-mi:Tlr9(display_short)	psi-mi:at2a2_rat(display_long)|uniprotkb:Calcium pump 2(gene name synonym)|uniprotkb:Calcium-transporting ATPase sarcoplasmic reticulum type, slow twitch skeletal muscle isoform(gene name synonym)|uniprotkb:"Endoplasmic reticulum class 1/2 Ca(2+) ATPase"(gene name synonym)|uniprotkb:Atp2a2(gene name)|psi-mi:Atp2a2(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Shintani et al. (2014)	imex:IM-23524|pubmed:24610369	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-9980176|imex:IM-23524-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000045322(gene)|ensembl:ENSMUST00000062241(transcript)|go:"GO:0001774"(microglial cell activation)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0002224"(toll-like receptor signaling pathway)|go:"GO:0002237"(response to molecule of bacterial origin)|go:"GO:0002639"(positive regulation of immunoglobulin production)|go:"GO:0002730"(regulation of dendritic cell cytokine production)|go:"GO:0002755"(MyD88-dependent toll-like receptor signaling pathway)|go:"GO:0005149"(interleukin-1 receptor binding)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|refseq:NP_112455.2|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0045087"(innate immune response)|go:"GO:0045322"(unmethylated CpG binding)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0045577"(regulation of B cell differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0050864"(regulation of B cell activation)|go:"GO:0050871"(positive regulation of B cell activation)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051607"(defense response to virus)|go:"GO:0051770"(positive regulation of nitric-oxide synthase biosynthetic process)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071248"(cellular response to metal ion)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:0005886"(plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0007252"(I-kappaB phosphorylation)|go:"GO:0008584"(male gonad development)|go:"GO:0009615"(response to virus)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030277"(maintenance of gastrointestinal epithelium)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0032009"(early phagosome)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032717"(negative regulation of interleukin-8 production)|go:"GO:0005789"(endoplasmic reticulum membrane)|rcsb pdb:4QDH|rcsb pdb:5ZLN|reactome:R-MMU-109704|reactome:R-MMU-1679131|reactome:R-MMU-168138|go:"GO:1901895"(negative regulation of ATPase-coupled calcium transmembrane transporter activity)|go:"GO:1902350"(cellular response to chloroquine)|interpro:IPR000157(Toll-Interleukin receptor)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR027181|interpro:IPR035897|interpro:IPR041283|mint:Q9EQU3|rcsb pdb:3WPF|rcsb pdb:3WPG|rcsb pdb:3WPH|rcsb pdb:3WPI|go:"GO:0032725"(positive regulation of granulocyte macrophage colony-stimulating factor production)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032741"(positive regulation of interleukin-18 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0034122"(negative regulation of toll-like receptor signaling pathway)|go:"GO:0034123"(positive regulation of toll-like receptor signaling pathway)|go:"GO:0034162"(toll-like receptor 9 signaling pathway)|go:"GO:0034163"(regulation of toll-like receptor 9 signaling pathway)|go:"GO:0034165"(positive regulation of toll-like receptor 9 signaling pathway)|go:"GO:0035197"(siRNA binding)|go:"GO:0036019"(endolysosome)|go:"GO:0038187"(pattern recognition receptor activity)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0032722"(positive regulation of chemokine production)	ensembl:ENSRNOG00000001285(gene)|ensembl:ENSRNOT00000024347(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0002026"(regulation of the force of heart contraction)|go:"GO:0003009"(skeletal muscle contraction)|go:"GO:0005388"(P-type calcium transporter activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006937"(regulation of muscle contraction)|go:"GO:0006984"(ER-nucleus signaling pathway)|go:"GO:0006996"(organelle organization)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008553"(P-type proton-exporting transporter activity)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0012506"(vesicle membrane)|go:"GO:0014883"(transition between fast and slow fiber)|go:"GO:0120025"(plasma membrane bounded cell projection)|go:"GO:0140056"(organelle localization by membrane tethering)|go:"GO:1900121"(negative regulation of receptor binding)|go:"GO:1903233"(regulation of calcium ion-dependent exocytosis of neurotransmitter)|go:"GO:1903515"(calcium ion transport from cytosol to endoplasmic reticulum)|go:"GO:1990036"(calcium ion import into sarcoplasmic reticulum)|go:"GO:1990456"(mitochondrion-endoplasmic reticulum membrane tethering)|interpro:IPR001757(ATPase, P-type, K/Mg/Cd/Cu/Zn/Na/Ca/Na/H-transporter)|interpro:IPR004014(ATPase, P-type cation-transporter, N-terminal)|interpro:IPR005782(Calcium ATPase)|interpro:IPR006068(ATPase, P-type cation-transporter, C-terminal)|interpro:IPR008250(E1-E2 ATPase-associated region)|interpro:IPR018303|interpro:IPR023214|interpro:IPR023298|interpro:IPR023299|interpro:IPR036412|interpro:IPR044492|mint:P11507|reactome:R-RNO-418359|reactome:R-RNO-5578775|reactome:R-RNO-936837|go:"GO:0014898"(cardiac muscle hypertrophy in response to stress)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016240"(autophagosome membrane docking)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0019899"(enzyme binding)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031775"(lutropin-choriogonadotropic hormone receptor binding)|go:"GO:0032469"(endoplasmic reticulum calcium ion homeostasis)|go:"GO:0032470"(positive regulation of endoplasmic reticulum calcium ion concentration)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033017"(sarcoplasmic reticulum membrane)|go:"GO:0033292"(T-tubule organization)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0034605"(cellular response to heat)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044548"(S100 protein binding)|go:"GO:0045822"(negative regulation of heart contraction)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0055119"(relaxation of cardiac muscle)|go:"GO:0061831"(apical ectoplasmic specialization)|go:"GO:0070296"(sarcoplasmic reticulum calcium ion transport)|go:"GO:0070588"(calcium ion transmembrane transport)|go:"GO:0086036"(regulation of cardiac muscle cell membrane potential)|go:"GO:0086039"(P-type calcium transporter activity involved in regulation of cardiac muscle cell membrane potential)|go:"GO:0097470"(ribbon synapse)|go:"GO:0098909"(regulation of cardiac muscle cell action potential involved in regulation of contraction)|rgd:2174|refseq:NP_001103609.1|refseq:NP_001104293.1	-	-	-	figure legend:sf2b|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat-cardiac_myocytes)|taxid:10116(rat cardiac myocytes)	-	2014/11/18	2014/11/19	rogid:3XKXj7PkEGE5qOchJfjMHFREkT010090	rogid:Et/ot4KEtlnq8iuoVL0CySJICIo10116	intact-crc:A684DF57B686B720|rigid:6HrHt05Ivg6RsFskX8kxxkrrYrY	false	calmodulin binding peptide plus protein a tag:c-c	-	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9EQU3	uniprotkb:P11507-2	intact:EBI-9979528|ensembl:ENSMUSP00000082207|uniprotkb:F8VPN5|uniprotkb:Q4L0K3|uniprotkb:Q4L0K4|uniprotkb:Q99MF2|uniprotkb:Q99MQ8	intact:EBI-9980182|ensembl:ENSRNOP00000001738	psi-mi:tlr9_mouse(display_long)|uniprotkb:Tlr9(gene name)|psi-mi:Tlr9(display_short)	psi-mi:p11507-2(display_long)|uniprotkb:Atp2a2a(isoform synonym)|uniprotkb:SERCA2a(isoform synonym)|uniprotkb:Atp2a2(gene name)|psi-mi:Atp2a2(display_short)|uniprotkb:Calcium pump 2(gene name synonym)|uniprotkb:Calcium-transporting ATPase sarcoplasmic reticulum type, slow twitch skeletal muscle isoform(gene name synonym)|uniprotkb:"Endoplasmic reticulum class 1/2 Ca(2+) ATPase"(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Shintani et al. (2014)	imex:IM-23524|pubmed:24610369	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-9980176|imex:IM-23524-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000045322(gene)|ensembl:ENSMUST00000062241(transcript)|go:"GO:0001774"(microglial cell activation)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0002224"(toll-like receptor signaling pathway)|go:"GO:0002237"(response to molecule of bacterial origin)|go:"GO:0002639"(positive regulation of immunoglobulin production)|go:"GO:0002730"(regulation of dendritic cell cytokine production)|go:"GO:0002755"(MyD88-dependent toll-like receptor signaling pathway)|go:"GO:0005149"(interleukin-1 receptor binding)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|refseq:NP_112455.2|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0045087"(innate immune response)|go:"GO:0045322"(unmethylated CpG binding)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0045577"(regulation of B cell differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0050864"(regulation of B cell activation)|go:"GO:0050871"(positive regulation of B cell activation)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051607"(defense response to virus)|go:"GO:0051770"(positive regulation of nitric-oxide synthase biosynthetic process)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071248"(cellular response to metal ion)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:0005886"(plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0007252"(I-kappaB phosphorylation)|go:"GO:0008584"(male gonad development)|go:"GO:0009615"(response to virus)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030277"(maintenance of gastrointestinal epithelium)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0032009"(early phagosome)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032717"(negative regulation of interleukin-8 production)|go:"GO:0005789"(endoplasmic reticulum membrane)|rcsb pdb:4QDH|rcsb pdb:5ZLN|reactome:R-MMU-109704|reactome:R-MMU-1679131|reactome:R-MMU-168138|go:"GO:1901895"(negative regulation of ATPase-coupled calcium transmembrane transporter activity)|go:"GO:1902350"(cellular response to chloroquine)|interpro:IPR000157(Toll-Interleukin receptor)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR027181|interpro:IPR035897|interpro:IPR041283|mint:Q9EQU3|rcsb pdb:3WPF|rcsb pdb:3WPG|rcsb pdb:3WPH|rcsb pdb:3WPI|go:"GO:0032725"(positive regulation of granulocyte macrophage colony-stimulating factor production)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032741"(positive regulation of interleukin-18 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0034122"(negative regulation of toll-like receptor signaling pathway)|go:"GO:0034123"(positive regulation of toll-like receptor signaling pathway)|go:"GO:0034162"(toll-like receptor 9 signaling pathway)|go:"GO:0034163"(regulation of toll-like receptor 9 signaling pathway)|go:"GO:0034165"(positive regulation of toll-like receptor 9 signaling pathway)|go:"GO:0035197"(siRNA binding)|go:"GO:0036019"(endolysosome)|go:"GO:0038187"(pattern recognition receptor activity)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0032722"(positive regulation of chemokine production)	intact:EBI-916319(isoform-parent)|ensembl:ENSRNOG00000001285(gene)|ensembl:ENSRNOT00000001738(transcript)	-	-	-	figure legend:sf2b|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat-cardiac_myocytes)|taxid:10116(rat cardiac myocytes)	-	2014/11/18	2014/11/19	rogid:3XKXj7PkEGE5qOchJfjMHFREkT010090	rogid:oaHB74ObnMOy6Ud+l5pkbPmqhQ810116	intact-crc:A684DF57B686B720|rigid:6HrHt05Ivg6RsFskX8kxxkrrYrY	false	calmodulin binding peptide plus protein a tag:c-c	-	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9EQU3	uniprotkb:O55143	intact:EBI-9979528|ensembl:ENSMUSP00000082207|uniprotkb:F8VPN5|uniprotkb:Q4L0K3|uniprotkb:Q4L0K4|uniprotkb:Q99MF2|uniprotkb:Q99MQ8	intact:EBI-770763|uniprotkb:Q9R2A9|uniprotkb:Q9WUT5|ensembl:ENSMUSP00000031423|ensembl:ENSMUSP00000135935	psi-mi:tlr9_mouse(display_long)|uniprotkb:Tlr9(gene name)|psi-mi:Tlr9(display_short)	psi-mi:at2a2_mouse(display_long)|uniprotkb:Calcium pump 2(gene name synonym)|uniprotkb:Calcium-transporting ATPase sarcoplasmic reticulum type, slow twitch skeletal muscle isoform(gene name synonym)|uniprotkb:"Endoplasmic reticulum class 1/2 Ca(2+) ATPase"(gene name synonym)|uniprotkb:Atp2a2(gene name)|psi-mi:Atp2a2(display_short)	psi-mi:"MI:0030"(cross-linking study)	Shintani et al. (2014)	imex:IM-23524|pubmed:24610369	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-9980390|imex:IM-23524-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000045322(gene)|ensembl:ENSMUST00000062241(transcript)|go:"GO:0001774"(microglial cell activation)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0002224"(toll-like receptor signaling pathway)|go:"GO:0002237"(response to molecule of bacterial origin)|go:"GO:0002639"(positive regulation of immunoglobulin production)|go:"GO:0002730"(regulation of dendritic cell cytokine production)|go:"GO:0002755"(MyD88-dependent toll-like receptor signaling pathway)|go:"GO:0005149"(interleukin-1 receptor binding)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|refseq:NP_112455.2|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0045087"(innate immune response)|go:"GO:0045322"(unmethylated CpG binding)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0045577"(regulation of B cell differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0050864"(regulation of B cell activation)|go:"GO:0050871"(positive regulation of B cell activation)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051607"(defense response to virus)|go:"GO:0051770"(positive regulation of nitric-oxide synthase biosynthetic process)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071248"(cellular response to metal ion)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:0005886"(plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0007252"(I-kappaB phosphorylation)|go:"GO:0008584"(male gonad development)|go:"GO:0009615"(response to virus)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030277"(maintenance of gastrointestinal epithelium)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0032009"(early phagosome)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032717"(negative regulation of interleukin-8 production)|go:"GO:0005789"(endoplasmic reticulum membrane)|rcsb pdb:4QDH|rcsb pdb:5ZLN|reactome:R-MMU-109704|reactome:R-MMU-1679131|reactome:R-MMU-168138|go:"GO:1901895"(negative regulation of ATPase-coupled calcium transmembrane transporter activity)|go:"GO:1902350"(cellular response to chloroquine)|interpro:IPR000157(Toll-Interleukin receptor)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR027181|interpro:IPR035897|interpro:IPR041283|mint:Q9EQU3|rcsb pdb:3WPF|rcsb pdb:3WPG|rcsb pdb:3WPH|rcsb pdb:3WPI|go:"GO:0032725"(positive regulation of granulocyte macrophage colony-stimulating factor production)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032741"(positive regulation of interleukin-18 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0034122"(negative regulation of toll-like receptor signaling pathway)|go:"GO:0034123"(positive regulation of toll-like receptor signaling pathway)|go:"GO:0034162"(toll-like receptor 9 signaling pathway)|go:"GO:0034163"(regulation of toll-like receptor 9 signaling pathway)|go:"GO:0034165"(positive regulation of toll-like receptor 9 signaling pathway)|go:"GO:0035197"(siRNA binding)|go:"GO:0036019"(endolysosome)|go:"GO:0038187"(pattern recognition receptor activity)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0032722"(positive regulation of chemokine production)	refseq:NP_001103610.1|refseq:NP_033852.1|go:"GO:0005509"(calcium ion binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005388"(P-type calcium transporter activity)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006937"(regulation of muscle contraction)|go:"GO:0006984"(ER-nucleus signaling pathway)|go:"GO:0006996"(organelle organization)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008553"(P-type proton-exporting transporter activity)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0012506"(vesicle membrane)|go:"GO:0014801"(longitudinal sarcoplasmic reticulum)|go:"GO:0014883"(transition between fast and slow fiber)|go:"GO:0014898"(cardiac muscle hypertrophy in response to stress)|go:"GO:0016020"(membrane)|go:"GO:0016240"(autophagosome membrane docking)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0019899"(enzyme binding)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031775"(lutropin-choriogonadotropic hormone receptor binding)|go:"GO:0032469"(endoplasmic reticulum calcium ion homeostasis)|go:"GO:0032470"(positive regulation of endoplasmic reticulum calcium ion concentration)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033017"(sarcoplasmic reticulum membrane)|go:"GO:0033292"(T-tubule organization)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0034605"(cellular response to heat)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044548"(S100 protein binding)|go:"GO:0045822"(negative regulation of heart contraction)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0055119"(relaxation of cardiac muscle)|go:"GO:0061831"(apical ectoplasmic specialization)|go:"GO:0070296"(sarcoplasmic reticulum calcium ion transport)|go:"GO:0070588"(calcium ion transmembrane transport)|go:"GO:0086036"(regulation of cardiac muscle cell membrane potential)|go:"GO:0086039"(P-type calcium transporter activity involved in regulation of cardiac muscle cell membrane potential)|go:"GO:0090534"(calcium ion-transporting ATPase complex)|go:"GO:0097470"(ribbon synapse)|go:"GO:0098909"(regulation of cardiac muscle cell action potential involved in regulation of contraction)|go:"GO:0120025"(plasma membrane bounded cell projection)|go:"GO:0140056"(organelle localization by membrane tethering)|go:"GO:1900121"(negative regulation of receptor binding)|go:"GO:1903233"(regulation of calcium ion-dependent exocytosis of neurotransmitter)|go:"GO:1903515"(calcium ion transport from cytosol to endoplasmic reticulum)|go:"GO:1990036"(calcium ion import into sarcoplasmic reticulum)|go:"GO:1990456"(mitochondrion-endoplasmic reticulum membrane tethering)|interpro:IPR001757(ATPase, P-type, K/Mg/Cd/Cu/Zn/Na/Ca/Na/H-transporter)|interpro:IPR004014(ATPase, P-type cation-transporter, N-terminal)|interpro:IPR005782(Calcium ATPase)|interpro:IPR006068(ATPase, P-type cation-transporter, C-terminal)|interpro:IPR008250(E1-E2 ATPase-associated region)|interpro:IPR018303|interpro:IPR023214|interpro:IPR023298|interpro:IPR023299|interpro:IPR036412|interpro:IPR044492|mint:O55143|reactome:R-MMU-418359|reactome:R-MMU-5578775|reactome:R-MMU-936837|ensembl:ENSMUSG00000029467(gene)|ensembl:ENSMUST00000031423(transcript)|ensembl:ENSMUST00000179939(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0002026"(regulation of the force of heart contraction)|go:"GO:0003009"(skeletal muscle contraction)	-	-	-	figure legend:f2a|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-cardiac myocyt)|taxid:10090(Mus musculus)	-	2014/11/18	2014/11/19	rogid:3XKXj7PkEGE5qOchJfjMHFREkT010090	rogid:LJG8hpHG2pO9ePikEKYbhsuCeRI10090	intact-crc:96DE710B700241D6|rigid:6QoqXh0JKbyPcETOQCLJcf/bJxY	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9EQU3	uniprotkb:P11507	intact:EBI-9979528|ensembl:ENSMUSP00000082207|uniprotkb:F8VPN5|uniprotkb:Q4L0K3|uniprotkb:Q4L0K4|uniprotkb:Q99MF2|uniprotkb:Q99MQ8	intact:EBI-916319|uniprotkb:P11508|ensembl:ENSRNOP00000024347	psi-mi:tlr9_mouse(display_long)|uniprotkb:Tlr9(gene name)|psi-mi:Tlr9(display_short)	psi-mi:at2a2_rat(display_long)|uniprotkb:Calcium pump 2(gene name synonym)|uniprotkb:Calcium-transporting ATPase sarcoplasmic reticulum type, slow twitch skeletal muscle isoform(gene name synonym)|uniprotkb:"Endoplasmic reticulum class 1/2 Ca(2+) ATPase"(gene name synonym)|uniprotkb:Atp2a2(gene name)|psi-mi:Atp2a2(display_short)	psi-mi:"MI:0428"(imaging technique)	Shintani et al. (2014)	imex:IM-23524|pubmed:24610369	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0471"(MINT)	intact:EBI-9980507|imex:IM-23524-6	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000045322(gene)|ensembl:ENSMUST00000062241(transcript)|go:"GO:0001774"(microglial cell activation)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0002224"(toll-like receptor signaling pathway)|go:"GO:0002237"(response to molecule of bacterial origin)|go:"GO:0002639"(positive regulation of immunoglobulin production)|go:"GO:0002730"(regulation of dendritic cell cytokine production)|go:"GO:0002755"(MyD88-dependent toll-like receptor signaling pathway)|go:"GO:0005149"(interleukin-1 receptor binding)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|refseq:NP_112455.2|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0045087"(innate immune response)|go:"GO:0045322"(unmethylated CpG binding)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0045577"(regulation of B cell differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0050864"(regulation of B cell activation)|go:"GO:0050871"(positive regulation of B cell activation)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051607"(defense response to virus)|go:"GO:0051770"(positive regulation of nitric-oxide synthase biosynthetic process)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071248"(cellular response to metal ion)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:0005886"(plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0007252"(I-kappaB phosphorylation)|go:"GO:0008584"(male gonad development)|go:"GO:0009615"(response to virus)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030277"(maintenance of gastrointestinal epithelium)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0032009"(early phagosome)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032717"(negative regulation of interleukin-8 production)|go:"GO:0005789"(endoplasmic reticulum membrane)|rcsb pdb:4QDH|rcsb pdb:5ZLN|reactome:R-MMU-109704|reactome:R-MMU-1679131|reactome:R-MMU-168138|go:"GO:1901895"(negative regulation of ATPase-coupled calcium transmembrane transporter activity)|go:"GO:1902350"(cellular response to chloroquine)|interpro:IPR000157(Toll-Interleukin receptor)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR027181|interpro:IPR035897|interpro:IPR041283|mint:Q9EQU3|rcsb pdb:3WPF|rcsb pdb:3WPG|rcsb pdb:3WPH|rcsb pdb:3WPI|go:"GO:0032725"(positive regulation of granulocyte macrophage colony-stimulating factor production)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032741"(positive regulation of interleukin-18 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0034122"(negative regulation of toll-like receptor signaling pathway)|go:"GO:0034123"(positive regulation of toll-like receptor signaling pathway)|go:"GO:0034162"(toll-like receptor 9 signaling pathway)|go:"GO:0034163"(regulation of toll-like receptor 9 signaling pathway)|go:"GO:0034165"(positive regulation of toll-like receptor 9 signaling pathway)|go:"GO:0035197"(siRNA binding)|go:"GO:0036019"(endolysosome)|go:"GO:0038187"(pattern recognition receptor activity)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0032722"(positive regulation of chemokine production)	ensembl:ENSRNOG00000001285(gene)|ensembl:ENSRNOT00000024347(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0002026"(regulation of the force of heart contraction)|go:"GO:0003009"(skeletal muscle contraction)|go:"GO:0005388"(P-type calcium transporter activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006937"(regulation of muscle contraction)|go:"GO:0006984"(ER-nucleus signaling pathway)|go:"GO:0006996"(organelle organization)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008553"(P-type proton-exporting transporter activity)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0012506"(vesicle membrane)|go:"GO:0014883"(transition between fast and slow fiber)|go:"GO:0120025"(plasma membrane bounded cell projection)|go:"GO:0140056"(organelle localization by membrane tethering)|go:"GO:1900121"(negative regulation of receptor binding)|go:"GO:1903233"(regulation of calcium ion-dependent exocytosis of neurotransmitter)|go:"GO:1903515"(calcium ion transport from cytosol to endoplasmic reticulum)|go:"GO:1990036"(calcium ion import into sarcoplasmic reticulum)|go:"GO:1990456"(mitochondrion-endoplasmic reticulum membrane tethering)|interpro:IPR001757(ATPase, P-type, K/Mg/Cd/Cu/Zn/Na/Ca/Na/H-transporter)|interpro:IPR004014(ATPase, P-type cation-transporter, N-terminal)|interpro:IPR005782(Calcium ATPase)|interpro:IPR006068(ATPase, P-type cation-transporter, C-terminal)|interpro:IPR008250(E1-E2 ATPase-associated region)|interpro:IPR018303|interpro:IPR023214|interpro:IPR023298|interpro:IPR023299|interpro:IPR036412|interpro:IPR044492|mint:P11507|reactome:R-RNO-418359|reactome:R-RNO-5578775|reactome:R-RNO-936837|go:"GO:0014898"(cardiac muscle hypertrophy in response to stress)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016240"(autophagosome membrane docking)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0019899"(enzyme binding)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031775"(lutropin-choriogonadotropic hormone receptor binding)|go:"GO:0032469"(endoplasmic reticulum calcium ion homeostasis)|go:"GO:0032470"(positive regulation of endoplasmic reticulum calcium ion concentration)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033017"(sarcoplasmic reticulum membrane)|go:"GO:0033292"(T-tubule organization)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0034605"(cellular response to heat)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044548"(S100 protein binding)|go:"GO:0045822"(negative regulation of heart contraction)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0055119"(relaxation of cardiac muscle)|go:"GO:0061831"(apical ectoplasmic specialization)|go:"GO:0070296"(sarcoplasmic reticulum calcium ion transport)|go:"GO:0070588"(calcium ion transmembrane transport)|go:"GO:0086036"(regulation of cardiac muscle cell membrane potential)|go:"GO:0086039"(P-type calcium transporter activity involved in regulation of cardiac muscle cell membrane potential)|go:"GO:0097470"(ribbon synapse)|go:"GO:0098909"(regulation of cardiac muscle cell action potential involved in regulation of contraction)|rgd:2174|refseq:NP_001103609.1|refseq:NP_001104293.1	go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0005783"(endoplasmic reticulum)	-	-	figure legend:f2b|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat-cardiac_myocytes_neo)|taxid:10116(rat cardiac myocytes neo)	-	2014/11/18	2014/11/19	rogid:3XKXj7PkEGE5qOchJfjMHFREkT010090	rogid:Et/ot4KEtlnq8iuoVL0CySJICIo10116	intact-crc:92DA00A71C0F0272|rigid:ccFBBjaz7Nk3/+xJTnDC+8CvEnk	false	calmodulin binding peptide plus protein a tag:c-c	-	-	-	psi-mi:"MI:0422"(immunostaining)	psi-mi:"MI:0422"(immunostaining)
uniprotkb:Q6Y1S0	uniprotkb:P11507	intact:EBI-9980577	intact:EBI-916319|uniprotkb:P11508|ensembl:ENSRNOP00000024347	psi-mi:q6y1s0_rat(display_long)|uniprotkb:Tlr9(gene name)|psi-mi:Tlr9(display_short)	psi-mi:at2a2_rat(display_long)|uniprotkb:Calcium pump 2(gene name synonym)|uniprotkb:Calcium-transporting ATPase sarcoplasmic reticulum type, slow twitch skeletal muscle isoform(gene name synonym)|uniprotkb:"Endoplasmic reticulum class 1/2 Ca(2+) ATPase"(gene name synonym)|uniprotkb:Atp2a2(gene name)|psi-mi:Atp2a2(display_short)	psi-mi:"MI:0428"(imaging technique)	Shintani et al. (2014)	imex:IM-23524|pubmed:24610369	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0471"(MINT)	intact:EBI-9980543|imex:IM-23524-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR003591(Leucine-rich repeat, typical subtype)|go:"GO:0001774"(microglial cell activation)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0002224"(toll-like receptor signaling pathway)|go:"GO:0002639"(positive regulation of immunoglobulin production)|go:"GO:0002730"(regulation of dendritic cell cytokine production)|go:"GO:0002755"(MyD88-dependent toll-like receptor signaling pathway)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005149"(interleukin-1 receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006955"(immune response)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0007252"(I-kappaB phosphorylation)|go:"GO:0008584"(male gonad development)|go:"GO:0009615"(response to virus)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030277"(maintenance of gastrointestinal epithelium)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0032009"(early phagosome)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032717"(negative regulation of interleukin-8 production)|go:"GO:0006954"(inflammatory response)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032725"(positive regulation of granulocyte macrophage colony-stimulating factor production)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032741"(positive regulation of interleukin-18 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0034122"(negative regulation of toll-like receptor signaling pathway)|go:"GO:0005886"(plasma membrane)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0045087"(innate immune response)|go:"GO:0045322"(unmethylated CpG binding)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0045577"(regulation of B cell differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0050864"(regulation of B cell activation)|go:"GO:0050871"(positive regulation of B cell activation)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051607"(defense response to virus)|go:"GO:0051770"(positive regulation of nitric-oxide synthase biosynthetic process)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071248"(cellular response to metal ion)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1901895"(negative regulation of ATPase-coupled calcium transmembrane transporter activity)|go:"GO:0034123"(positive regulation of toll-like receptor signaling pathway)|go:"GO:0034162"(toll-like receptor 9 signaling pathway)|go:"GO:0034163"(regulation of toll-like receptor 9 signaling pathway)|go:"GO:0034165"(positive regulation of toll-like receptor 9 signaling pathway)|go:"GO:1902350"(cellular response to chloroquine)|go:"GO:0035197"(siRNA binding)|go:"GO:0036019"(endolysosome)|go:"GO:0038187"(pattern recognition receptor activity)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043410"(positive regulation of MAPK cascade)|mint:Q6Y1S0|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR000157(Toll-Interleukin receptor)|interpro:IPR027181|rgd:631352|refseq:NP_937764.1|interpro:IPR035897|interpro:IPR041283	ensembl:ENSRNOG00000001285(gene)|ensembl:ENSRNOT00000024347(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0002026"(regulation of the force of heart contraction)|go:"GO:0003009"(skeletal muscle contraction)|go:"GO:0005388"(P-type calcium transporter activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006937"(regulation of muscle contraction)|go:"GO:0006984"(ER-nucleus signaling pathway)|go:"GO:0006996"(organelle organization)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008553"(P-type proton-exporting transporter activity)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0012506"(vesicle membrane)|go:"GO:0014883"(transition between fast and slow fiber)|go:"GO:0120025"(plasma membrane bounded cell projection)|go:"GO:0140056"(organelle localization by membrane tethering)|go:"GO:1900121"(negative regulation of receptor binding)|go:"GO:1903233"(regulation of calcium ion-dependent exocytosis of neurotransmitter)|go:"GO:1903515"(calcium ion transport from cytosol to endoplasmic reticulum)|go:"GO:1990036"(calcium ion import into sarcoplasmic reticulum)|go:"GO:1990456"(mitochondrion-endoplasmic reticulum membrane tethering)|interpro:IPR001757(ATPase, P-type, K/Mg/Cd/Cu/Zn/Na/Ca/Na/H-transporter)|interpro:IPR004014(ATPase, P-type cation-transporter, N-terminal)|interpro:IPR005782(Calcium ATPase)|interpro:IPR006068(ATPase, P-type cation-transporter, C-terminal)|interpro:IPR008250(E1-E2 ATPase-associated region)|interpro:IPR018303|interpro:IPR023214|interpro:IPR023298|interpro:IPR023299|interpro:IPR036412|interpro:IPR044492|mint:P11507|reactome:R-RNO-418359|reactome:R-RNO-5578775|reactome:R-RNO-936837|go:"GO:0014898"(cardiac muscle hypertrophy in response to stress)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016240"(autophagosome membrane docking)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0019899"(enzyme binding)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031775"(lutropin-choriogonadotropic hormone receptor binding)|go:"GO:0032469"(endoplasmic reticulum calcium ion homeostasis)|go:"GO:0032470"(positive regulation of endoplasmic reticulum calcium ion concentration)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033017"(sarcoplasmic reticulum membrane)|go:"GO:0033292"(T-tubule organization)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0034605"(cellular response to heat)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044548"(S100 protein binding)|go:"GO:0045822"(negative regulation of heart contraction)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0055119"(relaxation of cardiac muscle)|go:"GO:0061831"(apical ectoplasmic specialization)|go:"GO:0070296"(sarcoplasmic reticulum calcium ion transport)|go:"GO:0070588"(calcium ion transmembrane transport)|go:"GO:0086036"(regulation of cardiac muscle cell membrane potential)|go:"GO:0086039"(P-type calcium transporter activity involved in regulation of cardiac muscle cell membrane potential)|go:"GO:0097470"(ribbon synapse)|go:"GO:0098909"(regulation of cardiac muscle cell action potential involved in regulation of contraction)|rgd:2174|refseq:NP_001103609.1|refseq:NP_001104293.1	go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0005783"(endoplasmic reticulum)	-	-	figure legend:f2c|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat-cardiac_myocytes_neo)|taxid:10116(rat cardiac myocytes neo)	-	2014/11/18	2014/11/19	rogid:JHs05K7NAwyPrUd+aTk4Ta3kzUg10116	rogid:Et/ot4KEtlnq8iuoVL0CySJICIo10116	intact-crc:92DBB0A71C0F0272|rigid:8PWvXc/3gP9LVsxlFOVqGPxTuuo	false	-	-	-	-	psi-mi:"MI:0422"(immunostaining)	psi-mi:"MI:0422"(immunostaining)