#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:Q91029 uniprotkb:Q9PWH2 intact:EBI-9991388|uniprotkb:Q3L258|uniprotkb:Q5QEB6|uniprotkb:Q9PS91 intact:EBI-9991280 psi-mi:wnt1_chick(display_long)|uniprotkb:WNT1(gene name)|psi-mi:WNT1(display_short)|uniprotkb:WNT-1(gene name synonym) psi-mi:fzd10_chick(display_long)|uniprotkb:FZD10(gene name)|psi-mi:FZD10(display_short)|uniprotkb:FZ10(gene name synonym) psi-mi:"MI:0813"(proximity ligation assay) Galli et al. (2014) imex:IM-23324|pubmed:24599775 taxid:9031(chick)|taxid:9031("Gallus gallus (Chicken)") taxid:9031(chick)|taxid:9031("Gallus gallus (Chicken)") psi-mi:"MI:2364"(proximity) psi-mi:"MI:0469"(IntAct) intact:EBI-9991378|imex:IM-23324-2 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0005109"(frizzled binding)|go:"GO:0005125"(cytokine activity)|go:"GO:0005615"(extracellular space)|go:"GO:0006915"(apoptotic process)|go:"GO:0009953"(dorsal/ventral pattern formation)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0045165"(cell fate commitment)|go:"GO:0048263"(determination of dorsal identity)|go:"GO:0060070"(canonical Wnt signaling pathway)|interpro:IPR005817(Wnt superfamily)|interpro:IPR009139(Wnt-1 protein)|interpro:IPR043158|interpro:IPR018161|refseq:XP_015128668.1 go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0017147"(Wnt-protein binding)|go:"GO:0042813"(Wnt-activated receptor activity)|go:"GO:0060070"(canonical Wnt signaling pathway)|interpro:IPR000539(Frizzled protein)|interpro:IPR015526(Frizzled related)|interpro:IPR020067|interpro:IPR026549|interpro:IPR017981|refseq:NP_989429.1|interpro:IPR036790 - - - figure legend:4i|dataset:Affinomics - Interactions curated for the Affinomics consortium.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9534(chlae-cos_7)|taxid:9534(Cercopithecus aethiops simian cells transformed with SV40) - 2014/11/27 2018/03/08 rogid:IpTBHqahjVZyjwc6HbYjUgNYw1E9031 rogid:S43qHx136P8BG3Jn/kXg7m3i1kk9031 intact-crc:960CD3746B9F13CA|rigid:PtxJ33gxoSXtmWMjVMcXJxu5ESY false - - - - psi-mi:"MI:0421"(identification by antibody) psi-mi:"MI:0421"(identification by antibody) uniprotkb:Q2LMP1 uniprotkb:Q9PWH2 intact:EBI-9991304|uniprotkb:Q9PWH1|ensembl:ENSGALP00000045045 intact:EBI-9991280 psi-mi:wnt3a_chick(display_long)|uniprotkb:WNT3A(gene name)|psi-mi:WNT3A(display_short) psi-mi:fzd10_chick(display_long)|uniprotkb:FZD10(gene name)|psi-mi:FZD10(display_short)|uniprotkb:FZ10(gene name synonym) psi-mi:"MI:0813"(proximity ligation assay) Galli et al. (2014) imex:IM-23324|pubmed:24599775 taxid:9031(chick)|taxid:9031("Gallus gallus (Chicken)") taxid:9031(chick)|taxid:9031("Gallus gallus (Chicken)") psi-mi:"MI:2364"(proximity) psi-mi:"MI:0469"(IntAct) intact:EBI-9991161|imex:IM-23324-1 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001165072.1|refseq:NP_990006.2|ensembl:ENSGALG00000042657(gene)|ensembl:ENSGALT00000054282(transcript)|go:"GO:0005109"(frizzled binding)|go:"GO:0005125"(cytokine activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005640"(nuclear outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0009953"(dorsal/ventral pattern formation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010831"(positive regulation of myotube differentiation)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0035108"(limb morphogenesis)|go:"GO:0040036"(regulation of fibroblast growth factor receptor signaling pathway)|go:"GO:0042472"(inner ear morphogenesis)|go:"GO:0045165"(cell fate commitment)|go:"GO:0045663"(positive regulation of myoblast differentiation)|go:"GO:0045743"(positive regulation of fibroblast growth factor receptor signaling pathway)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048263"(determination of dorsal identity)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060173"(limb development)|go:"GO:0060828"(regulation of canonical Wnt signaling pathway)|go:"GO:0061303"(cornea development in camera-type eye)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|interpro:IPR005817(Wnt superfamily)|interpro:IPR009141(Wnt-3 protein)|interpro:IPR018161|interpro:IPR043158|reactome:R-GGA-201681|reactome:R-GGA-3238698|reactome:R-GGA-4641262|reactome:R-GGA-4641263 go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0017147"(Wnt-protein binding)|go:"GO:0042813"(Wnt-activated receptor activity)|go:"GO:0060070"(canonical Wnt signaling pathway)|interpro:IPR000539(Frizzled protein)|interpro:IPR015526(Frizzled related)|interpro:IPR020067|interpro:IPR026549|interpro:IPR017981|refseq:NP_989429.1|interpro:IPR036790 - - - figure legend:4/5|agonist:"LRP6 (a member of the low density lipoprotein receptor family.)"|dataset:Affinomics - Interactions curated for the Affinomics consortium.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9534(chlae-cos_7)|taxid:9534(Cercopithecus aethiops simian cells transformed with SV40) - 2014/11/27 2014/11/27 rogid:jiPpIFgkP2x1M4/Jue5SP5m9zNM9031 rogid:S43qHx136P8BG3Jn/kXg7m3i1kk9031 intact-crc:19B6F8035675B521|rigid:gSP4xcMoNzJXIAzOmBadAZXtuHU false - - - - psi-mi:"MI:0421"(identification by antibody) psi-mi:"MI:0421"(identification by antibody) uniprotkb:Q9PWH2 uniprotkb:Q91029 intact:EBI-9991280 intact:EBI-9991388|uniprotkb:Q3L258|uniprotkb:Q5QEB6|uniprotkb:Q9PS91 psi-mi:fzd10_chick(display_long)|uniprotkb:FZD10(gene name)|psi-mi:FZD10(display_short)|uniprotkb:FZ10(gene name synonym) psi-mi:wnt1_chick(display_long)|uniprotkb:WNT1(gene name)|psi-mi:WNT1(display_short)|uniprotkb:WNT-1(gene name synonym) psi-mi:"MI:0663"(confocal microscopy) Galli et al. (2014) imex:IM-23324|pubmed:24599775 taxid:9031(chick)|taxid:9031("Gallus gallus (Chicken)") taxid:9031(chick)|taxid:9031("Gallus gallus (Chicken)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9991447|imex:IM-23324-3 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0017147"(Wnt-protein binding)|go:"GO:0042813"(Wnt-activated receptor activity)|go:"GO:0060070"(canonical Wnt signaling pathway)|interpro:IPR000539(Frizzled protein)|interpro:IPR015526(Frizzled related)|interpro:IPR020067|interpro:IPR026549|interpro:IPR017981|refseq:NP_989429.1|interpro:IPR036790 go:"GO:0005109"(frizzled binding)|go:"GO:0005125"(cytokine activity)|go:"GO:0005615"(extracellular space)|go:"GO:0006915"(apoptotic process)|go:"GO:0009953"(dorsal/ventral pattern formation)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0045165"(cell fate commitment)|go:"GO:0048263"(determination of dorsal identity)|go:"GO:0060070"(canonical Wnt signaling pathway)|interpro:IPR005817(Wnt superfamily)|interpro:IPR009139(Wnt-1 protein)|interpro:IPR043158|interpro:IPR018161|refseq:XP_015128668.1 - - - figure legend:4i|dataset:Affinomics - Interactions curated for the Affinomics consortium.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9534(chlae-cos_7)|taxid:9534(Cercopithecus aethiops simian cells transformed with SV40) - 2014/11/27 2018/03/08 rogid:S43qHx136P8BG3Jn/kXg7m3i1kk9031 rogid:IpTBHqahjVZyjwc6HbYjUgNYw1E9031 intact-crc:126B073B8F57E9C5|rigid:PtxJ33gxoSXtmWMjVMcXJxu5ESY false - - - - psi-mi:"MI:1200"(immunocytochemistry) psi-mi:"MI:1200"(immunocytochemistry) uniprotkb:Q2LMP1 uniprotkb:Q9PWH2 intact:EBI-9991304|uniprotkb:Q9PWH1|ensembl:ENSGALP00000045045 intact:EBI-9991280 psi-mi:wnt3a_chick(display_long)|uniprotkb:WNT3A(gene name)|psi-mi:WNT3A(display_short) psi-mi:fzd10_chick(display_long)|uniprotkb:FZD10(gene name)|psi-mi:FZD10(display_short)|uniprotkb:FZ10(gene name synonym) psi-mi:"MI:0663"(confocal microscopy) Galli et al. (2014) imex:IM-23324|pubmed:24599775 taxid:9031(chick)|taxid:9031("Gallus gallus (Chicken)") taxid:9031(chick)|taxid:9031("Gallus gallus (Chicken)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9991449|imex:IM-23324-4 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001165072.1|refseq:NP_990006.2|ensembl:ENSGALG00000042657(gene)|ensembl:ENSGALT00000054282(transcript)|go:"GO:0005109"(frizzled binding)|go:"GO:0005125"(cytokine activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005640"(nuclear outer membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0009953"(dorsal/ventral pattern formation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010831"(positive regulation of myotube differentiation)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0035108"(limb morphogenesis)|go:"GO:0040036"(regulation of fibroblast growth factor receptor signaling pathway)|go:"GO:0042472"(inner ear morphogenesis)|go:"GO:0045165"(cell fate commitment)|go:"GO:0045663"(positive regulation of myoblast differentiation)|go:"GO:0045743"(positive regulation of fibroblast growth factor receptor signaling pathway)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048263"(determination of dorsal identity)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060173"(limb development)|go:"GO:0060828"(regulation of canonical Wnt signaling pathway)|go:"GO:0061303"(cornea development in camera-type eye)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|interpro:IPR005817(Wnt superfamily)|interpro:IPR009141(Wnt-3 protein)|interpro:IPR018161|interpro:IPR043158|reactome:R-GGA-201681|reactome:R-GGA-3238698|reactome:R-GGA-4641262|reactome:R-GGA-4641263 go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0017147"(Wnt-protein binding)|go:"GO:0042813"(Wnt-activated receptor activity)|go:"GO:0060070"(canonical Wnt signaling pathway)|interpro:IPR000539(Frizzled protein)|interpro:IPR015526(Frizzled related)|interpro:IPR020067|interpro:IPR026549|interpro:IPR017981|refseq:NP_989429.1|interpro:IPR036790 - - - figure legend:4|agonist:"LRP6 (a member of the low density lipoprotein receptor family.)"|dataset:Affinomics - Interactions curated for the Affinomics consortium.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9534(chlae-cos_7)|taxid:9534(Cercopithecus aethiops simian cells transformed with SV40) - 2014/11/27 2014/11/27 rogid:jiPpIFgkP2x1M4/Jue5SP5m9zNM9031 rogid:S43qHx136P8BG3Jn/kXg7m3i1kk9031 intact-crc:AB85F85CABA16F94|rigid:gSP4xcMoNzJXIAzOmBadAZXtuHU false - - - - psi-mi:"MI:1200"(immunocytochemistry) psi-mi:"MI:1200"(immunocytochemistry)