#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q12834	uniprotkb:O60566	intact:EBI-367462|uniprotkb:Q5JUY4|uniprotkb:Q9BW56|uniprotkb:Q9UQI9|uniprotkb:B2R6Z6|uniprotkb:D3DPJ1|ensembl:ENSP00000308450|ensembl:ENSP00000361540	intact:EBI-1001438|uniprotkb:B2R6U0|uniprotkb:B4DL09|uniprotkb:B4DLG3|uniprotkb:Q59HH6|uniprotkb:Q8WV50|intact:EBI-2551047|uniprotkb:O60501|uniprotkb:O60627|uniprotkb:O60758|uniprotkb:O75389|uniprotkb:Q96KM4|ensembl:ENSP00000287598	psi-mi:cdc20_human(display_long)|uniprotkb:CDC20(gene name)|psi-mi:CDC20(display_short)|uniprotkb:p55CDC(gene name synonym)	psi-mi:bub1b_human(display_long)|uniprotkb:MAD3/BUB1-related protein kinase(gene name synonym)|uniprotkb:Mitotic checkpoint kinase MAD3L(gene name synonym)|uniprotkb:SSK1(gene name synonym)|uniprotkb:BUB1B(gene name)|psi-mi:BUB1B(display_short)|uniprotkb:BUBR1(gene name synonym)|uniprotkb:MAD3L(gene name synonym)|uniprotkb:Protein SSK1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Rodriguez-Bravo et al. (2014)	pubmed:24581499|imex:IM-22572	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9519208|imex:IM-22572-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rcsb pdb:6Q6H|reactome:R-HSA-141405|reactome:R-HSA-141430|reactome:R-HSA-141444|reactome:R-HSA-174048|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-176407|reactome:R-HSA-176408|reactome:R-HSA-176409|reactome:R-HSA-176417|reactome:R-HSA-179409|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-5663220|reactome:R-HSA-5689880|reactome:R-HSA-68877|reactome:R-HSA-9648025|reactome:R-HSA-983168|go:"GO:0007399"(nervous system development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0007064"(mitotic sister chromatid cohesion)|go:"GO:0010997"(anaphase-promoting complex binding)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019899"(enzyme binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0031145"(anaphase-promoting complex-dependent catabolic process)|go:"GO:0031915"(positive regulation of synaptic plasticity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040020"(regulation of meiotic nuclear division)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050773"(regulation of dendrite development)|go:"GO:0051301"(cell division)|go:"GO:0090129"(positive regulation of synapse maturation)|go:"GO:0090307"(mitotic spindle assembly)|go:"GO:1904668"(positive regulation of ubiquitin protein ligase activity)|go:"GO:1905786"(positive regulation of anaphase-promoting complex-dependent catabolic process)|go:"GO:1990757"(ubiquitin ligase activator activity)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR024977|interpro:IPR033010|interpro:IPR036322|mint:Q12834|rcsb pdb:4GGA|rcsb pdb:4GGC|rcsb pdb:4GGD|rcsb pdb:4N14|rcsb pdb:5G04|rcsb pdb:5KHR|rcsb pdb:5KHU|rcsb pdb:5LCW|rcsb pdb:6F0X|rcsb pdb:6Q6G|refseq:NP_001246.2|ensembl:ENSG00000117399(gene)|ensembl:ENST00000310955(transcript)|ensembl:ENST00000372462(transcript)|go:"GO:0000922"(spindle pole)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|dip:DIP-29655N	refseq:NP_001202.4|dip:DIP-24203N|ensembl:ENSG00000156970(gene)|ensembl:ENST00000287598(transcript)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000776"(kinetochore)|go:"GO:0000940"(outer kinetochore)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005680"(anaphase-promoting complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0007091"(metaphase/anaphase transition of mitotic cell cycle)|go:"GO:0007093"(mitotic cell cycle checkpoint signaling)|go:"GO:0007094"(mitotic spindle assembly checkpoint signaling)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051301"(cell division)|go:"GO:0051754"(meiotic sister chromatid cohesion, centromeric)|go:"GO:0071459"(protein localization to chromosome, centromeric region)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR011009(Protein kinase-like)|interpro:IPR013212(Mad3/BUB1 homology region 1)|interpro:IPR015661(Mitotic checkpoint serine/threonine protein kinase, Bub1)|mint:O60566|rcsb pdb:2WVI|rcsb pdb:3SI5|rcsb pdb:4GGD|rcsb pdb:5JJA|rcsb pdb:5K6S|rcsb pdb:5KHU|rcsb pdb:5LCW|rcsb pdb:5SWF|rcsb pdb:6TLJ|reactome:R-HSA-141430|reactome:R-HSA-141444|reactome:R-HSA-174184|reactome:R-HSA-176409|reactome:R-HSA-179409|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-5663220|reactome:R-HSA-68877|reactome:R-HSA-9648025	-	-	-	figure legend:Fig. 2C|comment:Cdc20 binding to both Mad2 and BubR1 was severely compromised in the absence of Mad1.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-rpe)|taxid:9606(Human retinal pigment epithelium cell line)	-	2014/05/07	2014/10/16	rogid:15j9Heovw6LpbClp5kT9Wz6a88A9606	rogid:EgsQ2ZywEJ+r8hd95vcNEyikMBA9606	intact-crc:59249AEFF929837A|rigid:/2xo/ltZG/LkXG5VQr9vAIn39SA	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q12834	uniprotkb:Q13257	intact:EBI-367462|uniprotkb:Q5JUY4|uniprotkb:Q9BW56|uniprotkb:Q9UQI9|uniprotkb:B2R6Z6|uniprotkb:D3DPJ1|ensembl:ENSP00000308450|ensembl:ENSP00000361540	intact:EBI-78203|intact:EBI-28969404|ensembl:ENSP00000296509|uniprotkb:Q53F56|uniprotkb:Q548X9|uniprotkb:Q6IRW7|uniprotkb:Q8IZX3	psi-mi:cdc20_human(display_long)|uniprotkb:CDC20(gene name)|psi-mi:CDC20(display_short)|uniprotkb:p55CDC(gene name synonym)	psi-mi:md2l1_human(display_long)|uniprotkb:MAD2L1(gene name)|psi-mi:MAD2L1(display_short)|uniprotkb:MAD2(gene name synonym)|uniprotkb:Mitotic arrest deficient 2-like protein 1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Rodriguez-Bravo et al. (2014)	pubmed:24581499|imex:IM-22572	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9519208|imex:IM-22572-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rcsb pdb:6Q6H|reactome:R-HSA-141405|reactome:R-HSA-141430|reactome:R-HSA-141444|reactome:R-HSA-174048|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-176407|reactome:R-HSA-176408|reactome:R-HSA-176409|reactome:R-HSA-176417|reactome:R-HSA-179409|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-5663220|reactome:R-HSA-5689880|reactome:R-HSA-68877|reactome:R-HSA-9648025|reactome:R-HSA-983168|go:"GO:0007399"(nervous system development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0007064"(mitotic sister chromatid cohesion)|go:"GO:0010997"(anaphase-promoting complex binding)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019899"(enzyme binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0031145"(anaphase-promoting complex-dependent catabolic process)|go:"GO:0031915"(positive regulation of synaptic plasticity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040020"(regulation of meiotic nuclear division)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050773"(regulation of dendrite development)|go:"GO:0051301"(cell division)|go:"GO:0090129"(positive regulation of synapse maturation)|go:"GO:0090307"(mitotic spindle assembly)|go:"GO:1904668"(positive regulation of ubiquitin protein ligase activity)|go:"GO:1905786"(positive regulation of anaphase-promoting complex-dependent catabolic process)|go:"GO:1990757"(ubiquitin ligase activator activity)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR024977|interpro:IPR033010|interpro:IPR036322|mint:Q12834|rcsb pdb:4GGA|rcsb pdb:4GGC|rcsb pdb:4GGD|rcsb pdb:4N14|rcsb pdb:5G04|rcsb pdb:5KHR|rcsb pdb:5KHU|rcsb pdb:5LCW|rcsb pdb:6F0X|rcsb pdb:6Q6G|refseq:NP_001246.2|ensembl:ENSG00000117399(gene)|ensembl:ENST00000310955(transcript)|ensembl:ENST00000372462(transcript)|go:"GO:0000922"(spindle pole)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|dip:DIP-29655N	ensembl:ENSG00000164109(gene)|ensembl:ENST00000296509(transcript)|go:"GO:0000132"(establishment of mitotic spindle orientation)|go:"GO:0000776"(kinetochore)|go:"GO:0000922"(spindle pole)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007094"(mitotic spindle assembly checkpoint signaling)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044615"(nuclear pore nuclear basket)|go:"GO:0045930"(negative regulation of mitotic cell cycle)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051301"(cell division)|go:"GO:0051660"(establishment of centrosome localization)|go:"GO:0072686"(mitotic spindle)|go:"GO:0090267"(positive regulation of mitotic cell cycle spindle assembly checkpoint)|go:"GO:1904667"(negative regulation of ubiquitin protein ligase activity)|interpro:IPR003511(DNA-binding HORMA)|interpro:IPR036570|mint:Q13257|rcsb pdb:1DUJ|rcsb pdb:1GO4|rcsb pdb:1S2H|rcsb pdb:1KLQ|rcsb pdb:2QYF|rcsb pdb:2V64|rcsb pdb:2VFX|rcsb pdb:3GMH|rcsb pdb:5KHU|rcsb pdb:5LCW|rcsb pdb:6F0X|rcsb pdb:6TLJ|reactome:R-HSA-141405|reactome:R-HSA-141430|reactome:R-HSA-141444|reactome:R-HSA-174184|reactome:R-HSA-176409|reactome:R-HSA-179409|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-5663220|reactome:R-HSA-68877|reactome:R-HSA-9648025|ensembl:ENSP00000296509|ensembl:ENST00000333047|ensembl:ENSP00000332295|refseq:NP_002349.1|dip:DIP-29653N	-	-	-	figure legend:Fig. 2C|comment:Cdc20 binding to both Mad2 and BubR1 was severely compromised in the absence of Mad1.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-rpe)|taxid:9606(Human retinal pigment epithelium cell line)	-	2014/05/07	2014/10/16	rogid:15j9Heovw6LpbClp5kT9Wz6a88A9606	rogid:FyL1tmJllOZ4gQvwWb96aV9PMFw9606	intact-crc:59249AEFF929837A|rigid:/2xo/ltZG/LkXG5VQr9vAIn39SA	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q12834	uniprotkb:Q9Y6D9	intact:EBI-367462|uniprotkb:Q5JUY4|uniprotkb:Q9BW56|uniprotkb:Q9UQI9|uniprotkb:B2R6Z6|uniprotkb:D3DPJ1|ensembl:ENSP00000308450|ensembl:ENSP00000361540	intact:EBI-742610|uniprotkb:B3KR41|uniprotkb:Q9UNH0|uniprotkb:Q13312|uniprotkb:Q75MI0|uniprotkb:Q86UM4|ensembl:ENSP00000265854|ensembl:ENSP00000382562|ensembl:ENSP00000385334	psi-mi:cdc20_human(display_long)|uniprotkb:CDC20(gene name)|psi-mi:CDC20(display_short)|uniprotkb:p55CDC(gene name synonym)	psi-mi:md1l1_human(display_long)|uniprotkb:Mitotic arrest deficient 1-like protein 1(gene name synonym)|uniprotkb:Mitotic checkpoint MAD1 protein homolog(gene name synonym)|uniprotkb:Tax-binding protein 181(gene name synonym)|uniprotkb:MAD1L1(gene name)|psi-mi:MAD1L1(display_short)|uniprotkb:MAD1(gene name synonym)|uniprotkb:TXBP181(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Rodriguez-Bravo et al. (2014)	pubmed:24581499|imex:IM-22572	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9519208|imex:IM-22572-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rcsb pdb:6Q6H|reactome:R-HSA-141405|reactome:R-HSA-141430|reactome:R-HSA-141444|reactome:R-HSA-174048|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-176407|reactome:R-HSA-176408|reactome:R-HSA-176409|reactome:R-HSA-176417|reactome:R-HSA-179409|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-5663220|reactome:R-HSA-5689880|reactome:R-HSA-68877|reactome:R-HSA-9648025|reactome:R-HSA-983168|go:"GO:0007399"(nervous system development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0007064"(mitotic sister chromatid cohesion)|go:"GO:0010997"(anaphase-promoting complex binding)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019899"(enzyme binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0031145"(anaphase-promoting complex-dependent catabolic process)|go:"GO:0031915"(positive regulation of synaptic plasticity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040020"(regulation of meiotic nuclear division)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050773"(regulation of dendrite development)|go:"GO:0051301"(cell division)|go:"GO:0090129"(positive regulation of synapse maturation)|go:"GO:0090307"(mitotic spindle assembly)|go:"GO:1904668"(positive regulation of ubiquitin protein ligase activity)|go:"GO:1905786"(positive regulation of anaphase-promoting complex-dependent catabolic process)|go:"GO:1990757"(ubiquitin ligase activator activity)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR024977|interpro:IPR033010|interpro:IPR036322|mint:Q12834|rcsb pdb:4GGA|rcsb pdb:4GGC|rcsb pdb:4GGD|rcsb pdb:4N14|rcsb pdb:5G04|rcsb pdb:5KHR|rcsb pdb:5KHU|rcsb pdb:5LCW|rcsb pdb:6F0X|rcsb pdb:6Q6G|refseq:NP_001246.2|ensembl:ENSG00000117399(gene)|ensembl:ENST00000310955(transcript)|ensembl:ENST00000372462(transcript)|go:"GO:0000922"(spindle pole)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|dip:DIP-29655N	refseq:NP_001013858.1|refseq:NP_001013859.1|refseq:NP_003541.2|refseq:NP_001291452.1|refseq:NP_001291453.1|ensembl:ENSG00000002822(gene)|ensembl:ENST00000265854(transcript)|go:"GO:0090235"(regulation of metaphase plate congression)|go:"GO:1902426"(deactivation of mitotic spindle assembly checkpoint)|interpro:IPR008672(Mitotic checkpoint)|mint:Q9Y6D9|rcsb pdb:1GO4|rcsb pdb:4DZO|rcsb pdb:7B1F|rcsb pdb:7B1H|rcsb pdb:7B1J|reactome:R-HSA-141444|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-5663220|reactome:R-HSA-68877|reactome:R-HSA-9648025|ensembl:ENST00000399654(transcript)|ensembl:ENST00000406869(transcript)|go:"GO:0000776"(kinetochore)|go:"GO:0000922"(spindle pole)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0007094"(mitotic spindle assembly checkpoint signaling)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043515"(kinetochore binding)|go:"GO:0044615"(nuclear pore nuclear basket)|go:"GO:0048538"(thymus development)|go:"GO:0051220"(cytoplasmic sequestering of protein)|go:"GO:0051301"(cell division)|go:"GO:0051315"(attachment of mitotic spindle microtubules to kinetochore)|go:"GO:0072686"(mitotic spindle)|refseq:XP_005249934.1|dip:DIP-29654N	-	-	-	figure legend:Fig. 2C|comment:Cdc20 binding to both Mad2 and BubR1 was severely compromised in the absence of Mad1.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-rpe)|taxid:9606(Human retinal pigment epithelium cell line)	-	2014/05/07	2014/10/16	rogid:15j9Heovw6LpbClp5kT9Wz6a88A9606	rogid:9CcqpZlN0IgqC939rIo7vNgOvLQ9606	intact-crc:59249AEFF929837A|rigid:/2xo/ltZG/LkXG5VQr9vAIn39SA	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q12834	uniprotkb:Q13257	intact:EBI-367462|uniprotkb:Q5JUY4|uniprotkb:Q9BW56|uniprotkb:Q9UQI9|uniprotkb:B2R6Z6|uniprotkb:D3DPJ1|ensembl:ENSP00000308450|ensembl:ENSP00000361540	intact:EBI-78203|intact:EBI-28969404|ensembl:ENSP00000296509|uniprotkb:Q53F56|uniprotkb:Q548X9|uniprotkb:Q6IRW7|uniprotkb:Q8IZX3	psi-mi:cdc20_human(display_long)|uniprotkb:CDC20(gene name)|psi-mi:CDC20(display_short)|uniprotkb:p55CDC(gene name synonym)	psi-mi:md2l1_human(display_long)|uniprotkb:MAD2L1(gene name)|psi-mi:MAD2L1(display_short)|uniprotkb:MAD2(gene name synonym)|uniprotkb:Mitotic arrest deficient 2-like protein 1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Rodriguez-Bravo et al. (2014)	pubmed:24581499|imex:IM-22572	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9636923|imex:IM-22572-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rcsb pdb:6Q6H|reactome:R-HSA-141405|reactome:R-HSA-141430|reactome:R-HSA-141444|reactome:R-HSA-174048|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-176407|reactome:R-HSA-176408|reactome:R-HSA-176409|reactome:R-HSA-176417|reactome:R-HSA-179409|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-5663220|reactome:R-HSA-5689880|reactome:R-HSA-68877|reactome:R-HSA-9648025|reactome:R-HSA-983168|go:"GO:0007399"(nervous system development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0007064"(mitotic sister chromatid cohesion)|go:"GO:0010997"(anaphase-promoting complex binding)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019899"(enzyme binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0031145"(anaphase-promoting complex-dependent catabolic process)|go:"GO:0031915"(positive regulation of synaptic plasticity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040020"(regulation of meiotic nuclear division)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050773"(regulation of dendrite development)|go:"GO:0051301"(cell division)|go:"GO:0090129"(positive regulation of synapse maturation)|go:"GO:0090307"(mitotic spindle assembly)|go:"GO:1904668"(positive regulation of ubiquitin protein ligase activity)|go:"GO:1905786"(positive regulation of anaphase-promoting complex-dependent catabolic process)|go:"GO:1990757"(ubiquitin ligase activator activity)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR024977|interpro:IPR033010|interpro:IPR036322|mint:Q12834|rcsb pdb:4GGA|rcsb pdb:4GGC|rcsb pdb:4GGD|rcsb pdb:4N14|rcsb pdb:5G04|rcsb pdb:5KHR|rcsb pdb:5KHU|rcsb pdb:5LCW|rcsb pdb:6F0X|rcsb pdb:6Q6G|refseq:NP_001246.2|ensembl:ENSG00000117399(gene)|ensembl:ENST00000310955(transcript)|ensembl:ENST00000372462(transcript)|go:"GO:0000922"(spindle pole)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|dip:DIP-29655N	ensembl:ENSG00000164109(gene)|ensembl:ENST00000296509(transcript)|go:"GO:0000132"(establishment of mitotic spindle orientation)|go:"GO:0000776"(kinetochore)|go:"GO:0000922"(spindle pole)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007094"(mitotic spindle assembly checkpoint signaling)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044615"(nuclear pore nuclear basket)|go:"GO:0045930"(negative regulation of mitotic cell cycle)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051301"(cell division)|go:"GO:0051660"(establishment of centrosome localization)|go:"GO:0072686"(mitotic spindle)|go:"GO:0090267"(positive regulation of mitotic cell cycle spindle assembly checkpoint)|go:"GO:1904667"(negative regulation of ubiquitin protein ligase activity)|interpro:IPR003511(DNA-binding HORMA)|interpro:IPR036570|mint:Q13257|rcsb pdb:1DUJ|rcsb pdb:1GO4|rcsb pdb:1S2H|rcsb pdb:1KLQ|rcsb pdb:2QYF|rcsb pdb:2V64|rcsb pdb:2VFX|rcsb pdb:3GMH|rcsb pdb:5KHU|rcsb pdb:5LCW|rcsb pdb:6F0X|rcsb pdb:6TLJ|reactome:R-HSA-141405|reactome:R-HSA-141430|reactome:R-HSA-141444|reactome:R-HSA-174184|reactome:R-HSA-176409|reactome:R-HSA-179409|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-5663220|reactome:R-HSA-68877|reactome:R-HSA-9648025|ensembl:ENSP00000296509|ensembl:ENST00000333047|ensembl:ENSP00000332295|refseq:NP_002349.1|dip:DIP-29653N	go:"GO:0005737"(cytoplasm)	-	-	figure legend:Supp. Fig. 6D|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells)	-	2014/05/07	2014/10/16	rogid:15j9Heovw6LpbClp5kT9Wz6a88A9606	rogid:FyL1tmJllOZ4gQvwWb96aV9PMFw9606	intact-crc:BC4AC6B9038CF4BC|rigid:aFO9A6AU/kHSOsQ48EPrFnO5mWo	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q12834	uniprotkb:P12270	intact:EBI-367462|uniprotkb:Q5JUY4|uniprotkb:Q9BW56|uniprotkb:Q9UQI9|uniprotkb:B2R6Z6|uniprotkb:D3DPJ1|ensembl:ENSP00000308450|ensembl:ENSP00000361540	intact:EBI-1048528|uniprotkb:Q15655|uniprotkb:Q99968|uniprotkb:Q5SWY0|intact:EBI-2555905|uniprotkb:Q15624|intact:EBI-28974527|ensembl:ENSP00000356448	psi-mi:cdc20_human(display_long)|uniprotkb:CDC20(gene name)|psi-mi:CDC20(display_short)|uniprotkb:p55CDC(gene name synonym)	psi-mi:tpr_human(display_long)|uniprotkb:TPR(gene name)|psi-mi:TPR(display_short)|uniprotkb:Megator(gene name synonym)|uniprotkb:NPC-associated intranuclear protein(gene name synonym)|uniprotkb:Translocated promoter region protein(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Rodriguez-Bravo et al. (2014)	pubmed:24581499|imex:IM-22572	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9636923|imex:IM-22572-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rcsb pdb:6Q6H|reactome:R-HSA-141405|reactome:R-HSA-141430|reactome:R-HSA-141444|reactome:R-HSA-174048|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-176407|reactome:R-HSA-176408|reactome:R-HSA-176409|reactome:R-HSA-176417|reactome:R-HSA-179409|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-5663220|reactome:R-HSA-5689880|reactome:R-HSA-68877|reactome:R-HSA-9648025|reactome:R-HSA-983168|go:"GO:0007399"(nervous system development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0007064"(mitotic sister chromatid cohesion)|go:"GO:0010997"(anaphase-promoting complex binding)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019899"(enzyme binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0031145"(anaphase-promoting complex-dependent catabolic process)|go:"GO:0031915"(positive regulation of synaptic plasticity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040020"(regulation of meiotic nuclear division)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050773"(regulation of dendrite development)|go:"GO:0051301"(cell division)|go:"GO:0090129"(positive regulation of synapse maturation)|go:"GO:0090307"(mitotic spindle assembly)|go:"GO:1904668"(positive regulation of ubiquitin protein ligase activity)|go:"GO:1905786"(positive regulation of anaphase-promoting complex-dependent catabolic process)|go:"GO:1990757"(ubiquitin ligase activator activity)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR024977|interpro:IPR033010|interpro:IPR036322|mint:Q12834|rcsb pdb:4GGA|rcsb pdb:4GGC|rcsb pdb:4GGD|rcsb pdb:4N14|rcsb pdb:5G04|rcsb pdb:5KHR|rcsb pdb:5KHU|rcsb pdb:5LCW|rcsb pdb:6F0X|rcsb pdb:6Q6G|refseq:NP_001246.2|ensembl:ENSG00000117399(gene)|ensembl:ENST00000310955(transcript)|ensembl:ENST00000372462(transcript)|go:"GO:0000922"(spindle pole)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|dip:DIP-29655N	ensembl:ENSP00000356448|ensembl:ENST00000613151|ensembl:ENSP00000483425|refseq:NP_003283.2|go:"GO:0003682"(chromatin binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005643"(nuclear pore)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005868"(cytoplasmic dynein complex)|go:"GO:0006404"(RNA import into nucleus)|go:"GO:0006405"(RNA export from nucleus)|go:"GO:0006406"(mRNA export from nucleus)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006999"(nuclear pore organization)|go:"GO:0007094"(mitotic spindle assembly checkpoint signaling)|go:"GO:0010965"(regulation of mitotic sister chromatid separation)|go:"GO:0015631"(tubulin binding)|go:"GO:0017056"(structural constituent of nuclear pore)|go:"GO:0019898"(extrinsic component of membrane)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031453"(positive regulation of heterochromatin assembly)|go:"GO:0031965"(nuclear membrane)|go:"GO:0031990"(mRNA export from nucleus in response to heat stress)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0034399"(nuclear periphery)|go:"GO:0034605"(cellular response to heat)|go:"GO:0035457"(cellular response to interferon-alpha)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042405"(nuclear inclusion body)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0044615"(nuclear pore nuclear basket)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0046827"(positive regulation of protein export from nucleus)|go:"GO:0046832"(negative regulation of RNA export from nucleus)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0051301"(cell division)|go:"GO:0070840"(dynein complex binding)|go:"GO:0070849"(response to epidermal growth factor)|go:"GO:0072686"(mitotic spindle)|go:"GO:0090267"(positive regulation of mitotic cell cycle spindle assembly checkpoint)|go:"GO:0090316"(positive regulation of intracellular protein transport)|go:"GO:1901673"(regulation of mitotic spindle assembly)|interpro:IPR012929(Tetratricopeptide, MLP1/MLP2-like)|rcsb pdb:5TO5|rcsb pdb:5TO6|rcsb pdb:5TO7|rcsb pdb:5TVB|reactome:R-HSA-1169408|reactome:R-HSA-159227|ensembl:ENSG00000047410(gene)|ensembl:ENST00000367478(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000776"(kinetochore)|reactome:R-HSA-159230|reactome:R-HSA-159231|reactome:R-HSA-159236|reactome:R-HSA-165054|reactome:R-HSA-168271|reactome:R-HSA-168276|reactome:R-HSA-168325|reactome:R-HSA-168333|reactome:R-HSA-170822|reactome:R-HSA-180746|reactome:R-HSA-180910|reactome:R-HSA-191859|reactome:R-HSA-3108214|reactome:R-HSA-3232142|reactome:R-HSA-3301854|reactome:R-HSA-3371453|reactome:R-HSA-4085377|reactome:R-HSA-4551638|reactome:R-HSA-4570464|reactome:R-HSA-4615885|reactome:R-HSA-5578749|reactome:R-HSA-5619107|reactome:R-HSA-6784531|reactome:R-HSA-9609690|reactome:R-HSA-9610379|dip:DIP-50405N	go:"GO:0005737"(cytoplasm)	-	-	figure legend:Supp. Fig. 6D|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells)	-	2014/05/07	2014/10/16	rogid:15j9Heovw6LpbClp5kT9Wz6a88A9606	rogid:vgoHzJI4cSOfqPSDoy+E067AdoI9606	intact-crc:BC4AC6B9038CF4BC|rigid:aFO9A6AU/kHSOsQ48EPrFnO5mWo	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P12270	uniprotkb:Q9Y6D9	intact:EBI-1048528|uniprotkb:Q15655|uniprotkb:Q99968|uniprotkb:Q5SWY0|intact:EBI-2555905|uniprotkb:Q15624|intact:EBI-28974527|ensembl:ENSP00000356448	intact:EBI-742610|uniprotkb:B3KR41|uniprotkb:Q9UNH0|uniprotkb:Q13312|uniprotkb:Q75MI0|uniprotkb:Q86UM4|ensembl:ENSP00000265854|ensembl:ENSP00000382562|ensembl:ENSP00000385334	psi-mi:tpr_human(display_long)|uniprotkb:TPR(gene name)|psi-mi:TPR(display_short)|uniprotkb:Megator(gene name synonym)|uniprotkb:NPC-associated intranuclear protein(gene name synonym)|uniprotkb:Translocated promoter region protein(gene name synonym)	psi-mi:md1l1_human(display_long)|uniprotkb:Mitotic arrest deficient 1-like protein 1(gene name synonym)|uniprotkb:Mitotic checkpoint MAD1 protein homolog(gene name synonym)|uniprotkb:Tax-binding protein 181(gene name synonym)|uniprotkb:MAD1L1(gene name)|psi-mi:MAD1L1(display_short)|uniprotkb:MAD1(gene name synonym)|uniprotkb:TXBP181(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Rodriguez-Bravo et al. (2014)	pubmed:24581499|imex:IM-22572	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9521828|imex:IM-22572-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSP00000356448|ensembl:ENST00000613151|ensembl:ENSP00000483425|refseq:NP_003283.2|go:"GO:0003682"(chromatin binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005643"(nuclear pore)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005868"(cytoplasmic dynein complex)|go:"GO:0006404"(RNA import into nucleus)|go:"GO:0006405"(RNA export from nucleus)|go:"GO:0006406"(mRNA export from nucleus)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006999"(nuclear pore organization)|go:"GO:0007094"(mitotic spindle assembly checkpoint signaling)|go:"GO:0010965"(regulation of mitotic sister chromatid separation)|go:"GO:0015631"(tubulin binding)|go:"GO:0017056"(structural constituent of nuclear pore)|go:"GO:0019898"(extrinsic component of membrane)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031453"(positive regulation of heterochromatin assembly)|go:"GO:0031965"(nuclear membrane)|go:"GO:0031990"(mRNA export from nucleus in response to heat stress)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0034399"(nuclear periphery)|go:"GO:0034605"(cellular response to heat)|go:"GO:0035457"(cellular response to interferon-alpha)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042405"(nuclear inclusion body)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0044615"(nuclear pore nuclear basket)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0046827"(positive regulation of protein export from nucleus)|go:"GO:0046832"(negative regulation of RNA export from nucleus)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0051301"(cell division)|go:"GO:0070840"(dynein complex binding)|go:"GO:0070849"(response to epidermal growth factor)|go:"GO:0072686"(mitotic spindle)|go:"GO:0090267"(positive regulation of mitotic cell cycle spindle assembly checkpoint)|go:"GO:0090316"(positive regulation of intracellular protein transport)|go:"GO:1901673"(regulation of mitotic spindle assembly)|interpro:IPR012929(Tetratricopeptide, MLP1/MLP2-like)|rcsb pdb:5TO5|rcsb pdb:5TO6|rcsb pdb:5TO7|rcsb pdb:5TVB|reactome:R-HSA-1169408|reactome:R-HSA-159227|ensembl:ENSG00000047410(gene)|ensembl:ENST00000367478(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000776"(kinetochore)|reactome:R-HSA-159230|reactome:R-HSA-159231|reactome:R-HSA-159236|reactome:R-HSA-165054|reactome:R-HSA-168271|reactome:R-HSA-168276|reactome:R-HSA-168325|reactome:R-HSA-168333|reactome:R-HSA-170822|reactome:R-HSA-180746|reactome:R-HSA-180910|reactome:R-HSA-191859|reactome:R-HSA-3108214|reactome:R-HSA-3232142|reactome:R-HSA-3301854|reactome:R-HSA-3371453|reactome:R-HSA-4085377|reactome:R-HSA-4551638|reactome:R-HSA-4570464|reactome:R-HSA-4615885|reactome:R-HSA-5578749|reactome:R-HSA-5619107|reactome:R-HSA-6784531|reactome:R-HSA-9609690|reactome:R-HSA-9610379|dip:DIP-50405N	refseq:NP_001013858.1|refseq:NP_001013859.1|refseq:NP_003541.2|refseq:NP_001291452.1|refseq:NP_001291453.1|ensembl:ENSG00000002822(gene)|ensembl:ENST00000265854(transcript)|go:"GO:0090235"(regulation of metaphase plate congression)|go:"GO:1902426"(deactivation of mitotic spindle assembly checkpoint)|interpro:IPR008672(Mitotic checkpoint)|mint:Q9Y6D9|rcsb pdb:1GO4|rcsb pdb:4DZO|rcsb pdb:7B1F|rcsb pdb:7B1H|rcsb pdb:7B1J|reactome:R-HSA-141444|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-5663220|reactome:R-HSA-68877|reactome:R-HSA-9648025|ensembl:ENST00000399654(transcript)|ensembl:ENST00000406869(transcript)|go:"GO:0000776"(kinetochore)|go:"GO:0000922"(spindle pole)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0007094"(mitotic spindle assembly checkpoint signaling)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043515"(kinetochore binding)|go:"GO:0044615"(nuclear pore nuclear basket)|go:"GO:0048538"(thymus development)|go:"GO:0051220"(cytoplasmic sequestering of protein)|go:"GO:0051301"(cell division)|go:"GO:0051315"(attachment of mitotic spindle microtubules to kinetochore)|go:"GO:0072686"(mitotic spindle)|refseq:XP_005249934.1|dip:DIP-29654N	-	-	-	comment:Mad1-Tpr complexes were abundant in interphase but not mitotic extracts.|figure legend:Supp. Fig. 6C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells)	-	2014/05/07	2014/10/16	rogid:vgoHzJI4cSOfqPSDoy+E067AdoI9606	rogid:9CcqpZlN0IgqC939rIo7vNgOvLQ9606	intact-crc:6657A59177ADBDCB|rigid:4X8grXnkSOk5Cq6UcCRQA975fn8	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q13257	uniprotkb:Q9Y6D9	intact:EBI-78203|intact:EBI-28969404|ensembl:ENSP00000296509|uniprotkb:Q53F56|uniprotkb:Q548X9|uniprotkb:Q6IRW7|uniprotkb:Q8IZX3	intact:EBI-742610|uniprotkb:B3KR41|uniprotkb:Q9UNH0|uniprotkb:Q13312|uniprotkb:Q75MI0|uniprotkb:Q86UM4|ensembl:ENSP00000265854|ensembl:ENSP00000382562|ensembl:ENSP00000385334	psi-mi:md2l1_human(display_long)|uniprotkb:MAD2L1(gene name)|psi-mi:MAD2L1(display_short)|uniprotkb:MAD2(gene name synonym)|uniprotkb:Mitotic arrest deficient 2-like protein 1(gene name synonym)	psi-mi:md1l1_human(display_long)|uniprotkb:Mitotic arrest deficient 1-like protein 1(gene name synonym)|uniprotkb:Mitotic checkpoint MAD1 protein homolog(gene name synonym)|uniprotkb:Tax-binding protein 181(gene name synonym)|uniprotkb:MAD1L1(gene name)|psi-mi:MAD1L1(display_short)|uniprotkb:MAD1(gene name synonym)|uniprotkb:TXBP181(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Rodriguez-Bravo et al. (2014)	pubmed:24581499|imex:IM-22572	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9521786|imex:IM-22572-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000164109(gene)|ensembl:ENST00000296509(transcript)|go:"GO:0000132"(establishment of mitotic spindle orientation)|go:"GO:0000776"(kinetochore)|go:"GO:0000922"(spindle pole)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007094"(mitotic spindle assembly checkpoint signaling)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044615"(nuclear pore nuclear basket)|go:"GO:0045930"(negative regulation of mitotic cell cycle)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051301"(cell division)|go:"GO:0051660"(establishment of centrosome localization)|go:"GO:0072686"(mitotic spindle)|go:"GO:0090267"(positive regulation of mitotic cell cycle spindle assembly checkpoint)|go:"GO:1904667"(negative regulation of ubiquitin protein ligase activity)|interpro:IPR003511(DNA-binding HORMA)|interpro:IPR036570|mint:Q13257|rcsb pdb:1DUJ|rcsb pdb:1GO4|rcsb pdb:1S2H|rcsb pdb:1KLQ|rcsb pdb:2QYF|rcsb pdb:2V64|rcsb pdb:2VFX|rcsb pdb:3GMH|rcsb pdb:5KHU|rcsb pdb:5LCW|rcsb pdb:6F0X|rcsb pdb:6TLJ|reactome:R-HSA-141405|reactome:R-HSA-141430|reactome:R-HSA-141444|reactome:R-HSA-174184|reactome:R-HSA-176409|reactome:R-HSA-179409|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-5663220|reactome:R-HSA-68877|reactome:R-HSA-9648025|ensembl:ENSP00000296509|ensembl:ENST00000333047|ensembl:ENSP00000332295|refseq:NP_002349.1|dip:DIP-29653N	refseq:NP_001013858.1|refseq:NP_001013859.1|refseq:NP_003541.2|refseq:NP_001291452.1|refseq:NP_001291453.1|ensembl:ENSG00000002822(gene)|ensembl:ENST00000265854(transcript)|go:"GO:0090235"(regulation of metaphase plate congression)|go:"GO:1902426"(deactivation of mitotic spindle assembly checkpoint)|interpro:IPR008672(Mitotic checkpoint)|mint:Q9Y6D9|rcsb pdb:1GO4|rcsb pdb:4DZO|rcsb pdb:7B1F|rcsb pdb:7B1H|rcsb pdb:7B1J|reactome:R-HSA-141444|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-5663220|reactome:R-HSA-68877|reactome:R-HSA-9648025|ensembl:ENST00000399654(transcript)|ensembl:ENST00000406869(transcript)|go:"GO:0000776"(kinetochore)|go:"GO:0000922"(spindle pole)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0007094"(mitotic spindle assembly checkpoint signaling)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043515"(kinetochore binding)|go:"GO:0044615"(nuclear pore nuclear basket)|go:"GO:0048538"(thymus development)|go:"GO:0051220"(cytoplasmic sequestering of protein)|go:"GO:0051301"(cell division)|go:"GO:0051315"(attachment of mitotic spindle microtubules to kinetochore)|go:"GO:0072686"(mitotic spindle)|refseq:XP_005249934.1|dip:DIP-29654N	-	-	-	figure legend:Fig.  4E|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hct116)|taxid:9606(Human colon carcinoma HCT116 cells)	-	2014/05/07	2014/10/16	rogid:FyL1tmJllOZ4gQvwWb96aV9PMFw9606	rogid:9CcqpZlN0IgqC939rIo7vNgOvLQ9606	intact-crc:308112C63E6EAE07|rigid:Talluak0tlhelSLsCrnTGuG/8VA	false	-	tag:?-?|sufficient binding region:180-718	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q12834	uniprotkb:O60566	intact:EBI-367462|uniprotkb:Q5JUY4|uniprotkb:Q9BW56|uniprotkb:Q9UQI9|uniprotkb:B2R6Z6|uniprotkb:D3DPJ1|ensembl:ENSP00000308450|ensembl:ENSP00000361540	intact:EBI-1001438|uniprotkb:B2R6U0|uniprotkb:B4DL09|uniprotkb:B4DLG3|uniprotkb:Q59HH6|uniprotkb:Q8WV50|intact:EBI-2551047|uniprotkb:O60501|uniprotkb:O60627|uniprotkb:O60758|uniprotkb:O75389|uniprotkb:Q96KM4|ensembl:ENSP00000287598	psi-mi:cdc20_human(display_long)|uniprotkb:CDC20(gene name)|psi-mi:CDC20(display_short)|uniprotkb:p55CDC(gene name synonym)	psi-mi:bub1b_human(display_long)|uniprotkb:MAD3/BUB1-related protein kinase(gene name synonym)|uniprotkb:Mitotic checkpoint kinase MAD3L(gene name synonym)|uniprotkb:SSK1(gene name synonym)|uniprotkb:BUB1B(gene name)|psi-mi:BUB1B(display_short)|uniprotkb:BUBR1(gene name synonym)|uniprotkb:MAD3L(gene name synonym)|uniprotkb:Protein SSK1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Rodriguez-Bravo et al. (2014)	pubmed:24581499|imex:IM-22572	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9521780|imex:IM-22572-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rcsb pdb:6Q6H|reactome:R-HSA-141405|reactome:R-HSA-141430|reactome:R-HSA-141444|reactome:R-HSA-174048|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-176407|reactome:R-HSA-176408|reactome:R-HSA-176409|reactome:R-HSA-176417|reactome:R-HSA-179409|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-5663220|reactome:R-HSA-5689880|reactome:R-HSA-68877|reactome:R-HSA-9648025|reactome:R-HSA-983168|go:"GO:0007399"(nervous system development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0007064"(mitotic sister chromatid cohesion)|go:"GO:0010997"(anaphase-promoting complex binding)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019899"(enzyme binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0031145"(anaphase-promoting complex-dependent catabolic process)|go:"GO:0031915"(positive regulation of synaptic plasticity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040020"(regulation of meiotic nuclear division)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050773"(regulation of dendrite development)|go:"GO:0051301"(cell division)|go:"GO:0090129"(positive regulation of synapse maturation)|go:"GO:0090307"(mitotic spindle assembly)|go:"GO:1904668"(positive regulation of ubiquitin protein ligase activity)|go:"GO:1905786"(positive regulation of anaphase-promoting complex-dependent catabolic process)|go:"GO:1990757"(ubiquitin ligase activator activity)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR024977|interpro:IPR033010|interpro:IPR036322|mint:Q12834|rcsb pdb:4GGA|rcsb pdb:4GGC|rcsb pdb:4GGD|rcsb pdb:4N14|rcsb pdb:5G04|rcsb pdb:5KHR|rcsb pdb:5KHU|rcsb pdb:5LCW|rcsb pdb:6F0X|rcsb pdb:6Q6G|refseq:NP_001246.2|ensembl:ENSG00000117399(gene)|ensembl:ENST00000310955(transcript)|ensembl:ENST00000372462(transcript)|go:"GO:0000922"(spindle pole)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|dip:DIP-29655N	refseq:NP_001202.4|dip:DIP-24203N|ensembl:ENSG00000156970(gene)|ensembl:ENST00000287598(transcript)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000776"(kinetochore)|go:"GO:0000940"(outer kinetochore)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005680"(anaphase-promoting complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0007091"(metaphase/anaphase transition of mitotic cell cycle)|go:"GO:0007093"(mitotic cell cycle checkpoint signaling)|go:"GO:0007094"(mitotic spindle assembly checkpoint signaling)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051301"(cell division)|go:"GO:0051754"(meiotic sister chromatid cohesion, centromeric)|go:"GO:0071459"(protein localization to chromosome, centromeric region)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR011009(Protein kinase-like)|interpro:IPR013212(Mad3/BUB1 homology region 1)|interpro:IPR015661(Mitotic checkpoint serine/threonine protein kinase, Bub1)|mint:O60566|rcsb pdb:2WVI|rcsb pdb:3SI5|rcsb pdb:4GGD|rcsb pdb:5JJA|rcsb pdb:5K6S|rcsb pdb:5KHU|rcsb pdb:5LCW|rcsb pdb:5SWF|rcsb pdb:6TLJ|reactome:R-HSA-141430|reactome:R-HSA-141444|reactome:R-HSA-174184|reactome:R-HSA-176409|reactome:R-HSA-179409|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-5663220|reactome:R-HSA-68877|reactome:R-HSA-9648025	-	-	-	figure legend:Fig. 2C, 4I|comment:Cdc20 binding to both Mad2 and BubR1 was severely compromised in the absence of Mad1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hct116)|taxid:9606(Human colon carcinoma HCT116 cells)	-	2014/05/07	2014/10/16	rogid:15j9Heovw6LpbClp5kT9Wz6a88A9606	rogid:EgsQ2ZywEJ+r8hd95vcNEyikMBA9606	intact-crc:BDCDB460E5810AB5|rigid:1p2/kUKN7hVkvm7CXWXI4jbOFgg	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q12834	uniprotkb:Q13257	intact:EBI-367462|uniprotkb:Q5JUY4|uniprotkb:Q9BW56|uniprotkb:Q9UQI9|uniprotkb:B2R6Z6|uniprotkb:D3DPJ1|ensembl:ENSP00000308450|ensembl:ENSP00000361540	intact:EBI-78203|intact:EBI-28969404|ensembl:ENSP00000296509|uniprotkb:Q53F56|uniprotkb:Q548X9|uniprotkb:Q6IRW7|uniprotkb:Q8IZX3	psi-mi:cdc20_human(display_long)|uniprotkb:CDC20(gene name)|psi-mi:CDC20(display_short)|uniprotkb:p55CDC(gene name synonym)	psi-mi:md2l1_human(display_long)|uniprotkb:MAD2L1(gene name)|psi-mi:MAD2L1(display_short)|uniprotkb:MAD2(gene name synonym)|uniprotkb:Mitotic arrest deficient 2-like protein 1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Rodriguez-Bravo et al. (2014)	pubmed:24581499|imex:IM-22572	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9521780|imex:IM-22572-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rcsb pdb:6Q6H|reactome:R-HSA-141405|reactome:R-HSA-141430|reactome:R-HSA-141444|reactome:R-HSA-174048|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-176407|reactome:R-HSA-176408|reactome:R-HSA-176409|reactome:R-HSA-176417|reactome:R-HSA-179409|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-5663220|reactome:R-HSA-5689880|reactome:R-HSA-68877|reactome:R-HSA-9648025|reactome:R-HSA-983168|go:"GO:0007399"(nervous system development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0007064"(mitotic sister chromatid cohesion)|go:"GO:0010997"(anaphase-promoting complex binding)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019899"(enzyme binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0031145"(anaphase-promoting complex-dependent catabolic process)|go:"GO:0031915"(positive regulation of synaptic plasticity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040020"(regulation of meiotic nuclear division)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050773"(regulation of dendrite development)|go:"GO:0051301"(cell division)|go:"GO:0090129"(positive regulation of synapse maturation)|go:"GO:0090307"(mitotic spindle assembly)|go:"GO:1904668"(positive regulation of ubiquitin protein ligase activity)|go:"GO:1905786"(positive regulation of anaphase-promoting complex-dependent catabolic process)|go:"GO:1990757"(ubiquitin ligase activator activity)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR024977|interpro:IPR033010|interpro:IPR036322|mint:Q12834|rcsb pdb:4GGA|rcsb pdb:4GGC|rcsb pdb:4GGD|rcsb pdb:4N14|rcsb pdb:5G04|rcsb pdb:5KHR|rcsb pdb:5KHU|rcsb pdb:5LCW|rcsb pdb:6F0X|rcsb pdb:6Q6G|refseq:NP_001246.2|ensembl:ENSG00000117399(gene)|ensembl:ENST00000310955(transcript)|ensembl:ENST00000372462(transcript)|go:"GO:0000922"(spindle pole)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|dip:DIP-29655N	ensembl:ENSG00000164109(gene)|ensembl:ENST00000296509(transcript)|go:"GO:0000132"(establishment of mitotic spindle orientation)|go:"GO:0000776"(kinetochore)|go:"GO:0000922"(spindle pole)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007094"(mitotic spindle assembly checkpoint signaling)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044615"(nuclear pore nuclear basket)|go:"GO:0045930"(negative regulation of mitotic cell cycle)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051301"(cell division)|go:"GO:0051660"(establishment of centrosome localization)|go:"GO:0072686"(mitotic spindle)|go:"GO:0090267"(positive regulation of mitotic cell cycle spindle assembly checkpoint)|go:"GO:1904667"(negative regulation of ubiquitin protein ligase activity)|interpro:IPR003511(DNA-binding HORMA)|interpro:IPR036570|mint:Q13257|rcsb pdb:1DUJ|rcsb pdb:1GO4|rcsb pdb:1S2H|rcsb pdb:1KLQ|rcsb pdb:2QYF|rcsb pdb:2V64|rcsb pdb:2VFX|rcsb pdb:3GMH|rcsb pdb:5KHU|rcsb pdb:5LCW|rcsb pdb:6F0X|rcsb pdb:6TLJ|reactome:R-HSA-141405|reactome:R-HSA-141430|reactome:R-HSA-141444|reactome:R-HSA-174184|reactome:R-HSA-176409|reactome:R-HSA-179409|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-5663220|reactome:R-HSA-68877|reactome:R-HSA-9648025|ensembl:ENSP00000296509|ensembl:ENST00000333047|ensembl:ENSP00000332295|refseq:NP_002349.1|dip:DIP-29653N	-	-	-	figure legend:Fig. 2C, 4I|comment:Cdc20 binding to both Mad2 and BubR1 was severely compromised in the absence of Mad1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hct116)|taxid:9606(Human colon carcinoma HCT116 cells)	-	2014/05/07	2014/10/16	rogid:15j9Heovw6LpbClp5kT9Wz6a88A9606	rogid:FyL1tmJllOZ4gQvwWb96aV9PMFw9606	intact-crc:BDCDB460E5810AB5|rigid:1p2/kUKN7hVkvm7CXWXI4jbOFgg	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q12834	uniprotkb:Q13257	intact:EBI-367462|uniprotkb:Q5JUY4|uniprotkb:Q9BW56|uniprotkb:Q9UQI9|uniprotkb:B2R6Z6|uniprotkb:D3DPJ1|ensembl:ENSP00000308450|ensembl:ENSP00000361540	intact:EBI-78203|intact:EBI-28969404|ensembl:ENSP00000296509|uniprotkb:Q53F56|uniprotkb:Q548X9|uniprotkb:Q6IRW7|uniprotkb:Q8IZX3	psi-mi:cdc20_human(display_long)|uniprotkb:CDC20(gene name)|psi-mi:CDC20(display_short)|uniprotkb:p55CDC(gene name synonym)	psi-mi:md2l1_human(display_long)|uniprotkb:MAD2L1(gene name)|psi-mi:MAD2L1(display_short)|uniprotkb:MAD2(gene name synonym)|uniprotkb:Mitotic arrest deficient 2-like protein 1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Rodriguez-Bravo et al. (2014)	pubmed:24581499|imex:IM-22572	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9519219|imex:IM-22572-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rcsb pdb:6Q6H|reactome:R-HSA-141405|reactome:R-HSA-141430|reactome:R-HSA-141444|reactome:R-HSA-174048|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-176407|reactome:R-HSA-176408|reactome:R-HSA-176409|reactome:R-HSA-176417|reactome:R-HSA-179409|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-5663220|reactome:R-HSA-5689880|reactome:R-HSA-68877|reactome:R-HSA-9648025|reactome:R-HSA-983168|go:"GO:0007399"(nervous system development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0007064"(mitotic sister chromatid cohesion)|go:"GO:0010997"(anaphase-promoting complex binding)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019899"(enzyme binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0031145"(anaphase-promoting complex-dependent catabolic process)|go:"GO:0031915"(positive regulation of synaptic plasticity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040020"(regulation of meiotic nuclear division)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050773"(regulation of dendrite development)|go:"GO:0051301"(cell division)|go:"GO:0090129"(positive regulation of synapse maturation)|go:"GO:0090307"(mitotic spindle assembly)|go:"GO:1904668"(positive regulation of ubiquitin protein ligase activity)|go:"GO:1905786"(positive regulation of anaphase-promoting complex-dependent catabolic process)|go:"GO:1990757"(ubiquitin ligase activator activity)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR024977|interpro:IPR033010|interpro:IPR036322|mint:Q12834|rcsb pdb:4GGA|rcsb pdb:4GGC|rcsb pdb:4GGD|rcsb pdb:4N14|rcsb pdb:5G04|rcsb pdb:5KHR|rcsb pdb:5KHU|rcsb pdb:5LCW|rcsb pdb:6F0X|rcsb pdb:6Q6G|refseq:NP_001246.2|ensembl:ENSG00000117399(gene)|ensembl:ENST00000310955(transcript)|ensembl:ENST00000372462(transcript)|go:"GO:0000922"(spindle pole)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|dip:DIP-29655N	ensembl:ENSG00000164109(gene)|ensembl:ENST00000296509(transcript)|go:"GO:0000132"(establishment of mitotic spindle orientation)|go:"GO:0000776"(kinetochore)|go:"GO:0000922"(spindle pole)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007094"(mitotic spindle assembly checkpoint signaling)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044615"(nuclear pore nuclear basket)|go:"GO:0045930"(negative regulation of mitotic cell cycle)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051301"(cell division)|go:"GO:0051660"(establishment of centrosome localization)|go:"GO:0072686"(mitotic spindle)|go:"GO:0090267"(positive regulation of mitotic cell cycle spindle assembly checkpoint)|go:"GO:1904667"(negative regulation of ubiquitin protein ligase activity)|interpro:IPR003511(DNA-binding HORMA)|interpro:IPR036570|mint:Q13257|rcsb pdb:1DUJ|rcsb pdb:1GO4|rcsb pdb:1S2H|rcsb pdb:1KLQ|rcsb pdb:2QYF|rcsb pdb:2V64|rcsb pdb:2VFX|rcsb pdb:3GMH|rcsb pdb:5KHU|rcsb pdb:5LCW|rcsb pdb:6F0X|rcsb pdb:6TLJ|reactome:R-HSA-141405|reactome:R-HSA-141430|reactome:R-HSA-141444|reactome:R-HSA-174184|reactome:R-HSA-176409|reactome:R-HSA-179409|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-5663220|reactome:R-HSA-68877|reactome:R-HSA-9648025|ensembl:ENSP00000296509|ensembl:ENST00000333047|ensembl:ENSP00000332295|refseq:NP_002349.1|dip:DIP-29653N	go:"GO:0005737"(cytoplasm)	-	-	figure legend:Fig.  2G, 3F, 7C, Supp. Fig. 1E, 3C|comment:Interaction not seen in the absence of MAD1L1, in the  presence of catalytically dead mutant that cannot bind Mad2, MAD1L1 Lys541Ala  Lys543Ala, or in MAD1L1 lacking residues 1-274|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hct116)|taxid:9606(Human colon carcinoma HCT116 cells)	-	2014/05/07	2014/10/16	rogid:15j9Heovw6LpbClp5kT9Wz6a88A9606	rogid:FyL1tmJllOZ4gQvwWb96aV9PMFw9606	intact-crc:307E3BAC4D9A4CFB|rigid:IFBauuSnLNuTnn2APxdE4CZlSfU	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q12834	uniprotkb:Q9Y6D9	intact:EBI-367462|uniprotkb:Q5JUY4|uniprotkb:Q9BW56|uniprotkb:Q9UQI9|uniprotkb:B2R6Z6|uniprotkb:D3DPJ1|ensembl:ENSP00000308450|ensembl:ENSP00000361540	intact:EBI-742610|uniprotkb:B3KR41|uniprotkb:Q9UNH0|uniprotkb:Q13312|uniprotkb:Q75MI0|uniprotkb:Q86UM4|ensembl:ENSP00000265854|ensembl:ENSP00000382562|ensembl:ENSP00000385334	psi-mi:cdc20_human(display_long)|uniprotkb:CDC20(gene name)|psi-mi:CDC20(display_short)|uniprotkb:p55CDC(gene name synonym)	psi-mi:md1l1_human(display_long)|uniprotkb:Mitotic arrest deficient 1-like protein 1(gene name synonym)|uniprotkb:Mitotic checkpoint MAD1 protein homolog(gene name synonym)|uniprotkb:Tax-binding protein 181(gene name synonym)|uniprotkb:MAD1L1(gene name)|psi-mi:MAD1L1(display_short)|uniprotkb:MAD1(gene name synonym)|uniprotkb:TXBP181(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Rodriguez-Bravo et al. (2014)	pubmed:24581499|imex:IM-22572	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9519219|imex:IM-22572-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rcsb pdb:6Q6H|reactome:R-HSA-141405|reactome:R-HSA-141430|reactome:R-HSA-141444|reactome:R-HSA-174048|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-176407|reactome:R-HSA-176408|reactome:R-HSA-176409|reactome:R-HSA-176417|reactome:R-HSA-179409|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-5663220|reactome:R-HSA-5689880|reactome:R-HSA-68877|reactome:R-HSA-9648025|reactome:R-HSA-983168|go:"GO:0007399"(nervous system development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0007064"(mitotic sister chromatid cohesion)|go:"GO:0010997"(anaphase-promoting complex binding)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019899"(enzyme binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0031145"(anaphase-promoting complex-dependent catabolic process)|go:"GO:0031915"(positive regulation of synaptic plasticity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040020"(regulation of meiotic nuclear division)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050773"(regulation of dendrite development)|go:"GO:0051301"(cell division)|go:"GO:0090129"(positive regulation of synapse maturation)|go:"GO:0090307"(mitotic spindle assembly)|go:"GO:1904668"(positive regulation of ubiquitin protein ligase activity)|go:"GO:1905786"(positive regulation of anaphase-promoting complex-dependent catabolic process)|go:"GO:1990757"(ubiquitin ligase activator activity)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR024977|interpro:IPR033010|interpro:IPR036322|mint:Q12834|rcsb pdb:4GGA|rcsb pdb:4GGC|rcsb pdb:4GGD|rcsb pdb:4N14|rcsb pdb:5G04|rcsb pdb:5KHR|rcsb pdb:5KHU|rcsb pdb:5LCW|rcsb pdb:6F0X|rcsb pdb:6Q6G|refseq:NP_001246.2|ensembl:ENSG00000117399(gene)|ensembl:ENST00000310955(transcript)|ensembl:ENST00000372462(transcript)|go:"GO:0000922"(spindle pole)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|dip:DIP-29655N	refseq:NP_001013858.1|refseq:NP_001013859.1|refseq:NP_003541.2|refseq:NP_001291452.1|refseq:NP_001291453.1|ensembl:ENSG00000002822(gene)|ensembl:ENST00000265854(transcript)|go:"GO:0090235"(regulation of metaphase plate congression)|go:"GO:1902426"(deactivation of mitotic spindle assembly checkpoint)|interpro:IPR008672(Mitotic checkpoint)|mint:Q9Y6D9|rcsb pdb:1GO4|rcsb pdb:4DZO|rcsb pdb:7B1F|rcsb pdb:7B1H|rcsb pdb:7B1J|reactome:R-HSA-141444|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-5663220|reactome:R-HSA-68877|reactome:R-HSA-9648025|ensembl:ENST00000399654(transcript)|ensembl:ENST00000406869(transcript)|go:"GO:0000776"(kinetochore)|go:"GO:0000922"(spindle pole)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0007094"(mitotic spindle assembly checkpoint signaling)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043515"(kinetochore binding)|go:"GO:0044615"(nuclear pore nuclear basket)|go:"GO:0048538"(thymus development)|go:"GO:0051220"(cytoplasmic sequestering of protein)|go:"GO:0051301"(cell division)|go:"GO:0051315"(attachment of mitotic spindle microtubules to kinetochore)|go:"GO:0072686"(mitotic spindle)|refseq:XP_005249934.1|dip:DIP-29654N	go:"GO:0005737"(cytoplasm)	-	-	figure legend:Fig.  2G, 3F, 7C, Supp. Fig. 1E, 3C|comment:Interaction not seen in the absence of MAD1L1, in the  presence of catalytically dead mutant that cannot bind Mad2, MAD1L1 Lys541Ala  Lys543Ala, or in MAD1L1 lacking residues 1-274|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hct116)|taxid:9606(Human colon carcinoma HCT116 cells)	-	2014/05/07	2014/10/16	rogid:15j9Heovw6LpbClp5kT9Wz6a88A9606	rogid:9CcqpZlN0IgqC939rIo7vNgOvLQ9606	intact-crc:307E3BAC4D9A4CFB|rigid:IFBauuSnLNuTnn2APxdE4CZlSfU	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9Y6D9	uniprotkb:P12270	intact:EBI-742610|uniprotkb:B3KR41|uniprotkb:Q9UNH0|uniprotkb:Q13312|uniprotkb:Q75MI0|uniprotkb:Q86UM4|ensembl:ENSP00000265854|ensembl:ENSP00000382562|ensembl:ENSP00000385334	intact:EBI-1048528|uniprotkb:Q15655|uniprotkb:Q99968|uniprotkb:Q5SWY0|intact:EBI-2555905|uniprotkb:Q15624|intact:EBI-28974527|ensembl:ENSP00000356448	psi-mi:md1l1_human(display_long)|uniprotkb:Mitotic arrest deficient 1-like protein 1(gene name synonym)|uniprotkb:Mitotic checkpoint MAD1 protein homolog(gene name synonym)|uniprotkb:Tax-binding protein 181(gene name synonym)|uniprotkb:MAD1L1(gene name)|psi-mi:MAD1L1(display_short)|uniprotkb:MAD1(gene name synonym)|uniprotkb:TXBP181(gene name synonym)	psi-mi:tpr_human(display_long)|uniprotkb:TPR(gene name)|psi-mi:TPR(display_short)|uniprotkb:Megator(gene name synonym)|uniprotkb:NPC-associated intranuclear protein(gene name synonym)|uniprotkb:Translocated promoter region protein(gene name synonym)	psi-mi:"MI:0096"(pull down)	Rodriguez-Bravo et al. (2014)	pubmed:24581499|imex:IM-22572	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9522259|imex:IM-22572-6	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001013858.1|refseq:NP_001013859.1|refseq:NP_003541.2|refseq:NP_001291452.1|refseq:NP_001291453.1|ensembl:ENSG00000002822(gene)|ensembl:ENST00000265854(transcript)|go:"GO:0090235"(regulation of metaphase plate congression)|go:"GO:1902426"(deactivation of mitotic spindle assembly checkpoint)|interpro:IPR008672(Mitotic checkpoint)|mint:Q9Y6D9|rcsb pdb:1GO4|rcsb pdb:4DZO|rcsb pdb:7B1F|rcsb pdb:7B1H|rcsb pdb:7B1J|reactome:R-HSA-141444|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-5663220|reactome:R-HSA-68877|reactome:R-HSA-9648025|ensembl:ENST00000399654(transcript)|ensembl:ENST00000406869(transcript)|go:"GO:0000776"(kinetochore)|go:"GO:0000922"(spindle pole)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0007094"(mitotic spindle assembly checkpoint signaling)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043515"(kinetochore binding)|go:"GO:0044615"(nuclear pore nuclear basket)|go:"GO:0048538"(thymus development)|go:"GO:0051220"(cytoplasmic sequestering of protein)|go:"GO:0051301"(cell division)|go:"GO:0051315"(attachment of mitotic spindle microtubules to kinetochore)|go:"GO:0072686"(mitotic spindle)|refseq:XP_005249934.1|dip:DIP-29654N	ensembl:ENSP00000356448|ensembl:ENST00000613151|ensembl:ENSP00000483425|refseq:NP_003283.2|go:"GO:0003682"(chromatin binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005643"(nuclear pore)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005868"(cytoplasmic dynein complex)|go:"GO:0006404"(RNA import into nucleus)|go:"GO:0006405"(RNA export from nucleus)|go:"GO:0006406"(mRNA export from nucleus)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006999"(nuclear pore organization)|go:"GO:0007094"(mitotic spindle assembly checkpoint signaling)|go:"GO:0010965"(regulation of mitotic sister chromatid separation)|go:"GO:0015631"(tubulin binding)|go:"GO:0017056"(structural constituent of nuclear pore)|go:"GO:0019898"(extrinsic component of membrane)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031453"(positive regulation of heterochromatin assembly)|go:"GO:0031965"(nuclear membrane)|go:"GO:0031990"(mRNA export from nucleus in response to heat stress)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0034399"(nuclear periphery)|go:"GO:0034605"(cellular response to heat)|go:"GO:0035457"(cellular response to interferon-alpha)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042405"(nuclear inclusion body)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0044615"(nuclear pore nuclear basket)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0046827"(positive regulation of protein export from nucleus)|go:"GO:0046832"(negative regulation of RNA export from nucleus)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0051301"(cell division)|go:"GO:0070840"(dynein complex binding)|go:"GO:0070849"(response to epidermal growth factor)|go:"GO:0072686"(mitotic spindle)|go:"GO:0090267"(positive regulation of mitotic cell cycle spindle assembly checkpoint)|go:"GO:0090316"(positive regulation of intracellular protein transport)|go:"GO:1901673"(regulation of mitotic spindle assembly)|interpro:IPR012929(Tetratricopeptide, MLP1/MLP2-like)|rcsb pdb:5TO5|rcsb pdb:5TO6|rcsb pdb:5TO7|rcsb pdb:5TVB|reactome:R-HSA-1169408|reactome:R-HSA-159227|ensembl:ENSG00000047410(gene)|ensembl:ENST00000367478(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000776"(kinetochore)|reactome:R-HSA-159230|reactome:R-HSA-159231|reactome:R-HSA-159236|reactome:R-HSA-165054|reactome:R-HSA-168271|reactome:R-HSA-168276|reactome:R-HSA-168325|reactome:R-HSA-168333|reactome:R-HSA-170822|reactome:R-HSA-180746|reactome:R-HSA-180910|reactome:R-HSA-191859|reactome:R-HSA-3108214|reactome:R-HSA-3232142|reactome:R-HSA-3301854|reactome:R-HSA-3371453|reactome:R-HSA-4085377|reactome:R-HSA-4551638|reactome:R-HSA-4570464|reactome:R-HSA-4615885|reactome:R-HSA-5578749|reactome:R-HSA-5619107|reactome:R-HSA-6784531|reactome:R-HSA-9609690|reactome:R-HSA-9610379|dip:DIP-50405N	-	-	-	comment:Mad1-Tpr complexes were abundant in interphase but not mitotic extracts.|figure legend:Fig. 4B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/05/07	2014/10/16	rogid:9CcqpZlN0IgqC939rIo7vNgOvLQ9606	rogid:vgoHzJI4cSOfqPSDoy+E067AdoI9606	intact-crc:AB1365EB8F4C317F|rigid:4X8grXnkSOk5Cq6UcCRQA975fn8	false	his tag:?-?|sufficient binding region:1-244	sufficient binding region:1-775|35s radiolabel:?-?	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)