#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q6MG89	uniprotkb:Q63722	intact:EBI-9990401|ensembl:ENSRNOP00000000513	intact:EBI-4567800|uniprotkb:P70640	psi-mi:q6mg89_rat(display_long)|uniprotkb:Notch4(gene name)|psi-mi:Notch4(display_short)|uniprotkb:Ager(gene name synonym)|uniprotkb:Btnl6(gene name synonym)|uniprotkb:Cyp21a1-ps(gene name synonym)|uniprotkb:Ng5(gene name synonym)|uniprotkb:Rnf5(gene name synonym)|uniprotkb:Stk19-ps(gene name synonym)|uniprotkb:Tnx(gene name synonym)|uniprotkb:rCG_38227(orf name)	psi-mi:jag1_rat(display_long)|uniprotkb:Jag1(gene name)|psi-mi:Jag1(display_short)	psi-mi:"MI:0813"(proximity ligation assay)	Tu et al. (2014)	pubmed:24563863|imex:IM-23320	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9990453|imex:IM-23320-6	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSRNOG00000000442(gene)|ensembl:ENSRNOT00000000513(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001569"(branching involved in blood vessel morphogenesis)|go:"GO:0001763"(morphogenesis of a branching structure)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0001886"(endothelial cell morphogenesis)|go:"GO:0001944"(vasculature development)|go:"GO:0005112"(Notch binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005634"(nucleus)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0008593"(regulation of Notch signaling pathway)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030879"(mammary gland development)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042060"(wound healing)|go:"GO:0045446"(endothelial cell differentiation)|go:"GO:0045602"(negative regulation of endothelial cell differentiation)|go:"GO:0045746"(negative regulation of Notch signaling pathway)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0048845"(venous blood vessel morphogenesis)|go:"GO:0060354"(negative regulation of cell adhesion molecule production)|go:"GO:0070613"(regulation of protein processing)|go:"GO:1903849"(positive regulation of aorta morphogenesis)|go:"GO:2000048"(negative regulation of cell-cell adhesion mediated by cadherin)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR000800(Notch region)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR002110(Ankyrin)|interpro:IPR008297(Notch)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR010660(Notch, NOD region)|interpro:IPR011656(Notch, NODP region)|interpro:IPR013032(EGF-like region, conserved site)|interpro:IPR018097|interpro:IPR020683|interpro:IPR022355|interpro:IPR035993|interpro:IPR036770|reactome:R-RNO-1912420|reactome:R-RNO-9013700|reactome:R-RNO-9604323|rgd:1303282|refseq:NP_001002827.1	interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR018097|interpro:IPR011651(Notch ligand, N-terminal)|rgd:2937|refseq:NP_062020.1|interpro:IPR001774("Delta/Serrate/lag-2 (DSL) protein")|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR001007(von Willebrand factor, type C)|interpro:IPR013032(EGF-like region, conserved site)|rcsb pdb:5UK5|interpro:IPR026219|interpro:IPR009030(Growth factor, receptor)|reactome:R-RNO-9013507|interpro:IPR033108|go:"GO:0001709"(cell fate determination)|go:"GO:0001953"(negative regulation of cell-matrix adhesion)|go:"GO:0001974"(blood vessel remodeling)|go:"GO:0002011"(morphogenesis of an epithelial sheet)|go:"GO:0002456"(T cell mediated immunity)|go:"GO:0003184"(pulmonary valve morphogenesis)|go:"GO:0003215"(cardiac right ventricle morphogenesis)|go:"GO:0005112"(Notch binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0045602"(negative regulation of endothelial cell differentiation)|go:"GO:0045639"(positive regulation of myeloid cell differentiation)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045747"(positive regulation of Notch signaling pathway)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048018"(receptor ligand activity)|go:"GO:0048839"(inner ear development)|go:"GO:0060411"(cardiac septum morphogenesis)|go:"GO:0061073"(ciliary body morphogenesis)|go:"GO:0061156"(pulmonary artery morphogenesis)|go:"GO:0061309"(cardiac neural crest cell development involved in outflow tract morphogenesis)|go:"GO:0061314"(Notch signaling involved in heart development)|go:"GO:0022408"(negative regulation of cell-cell adhesion)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0061444"(endocardial cushion cell development)|go:"GO:0062043"(positive regulation of cardiac epithelial to mesenchymal transition)|go:"GO:0072006"(nephron development)|go:"GO:0072015"(glomerular visceral epithelial cell development)|go:"GO:0072017"(distal tubule development)|go:"GO:0072070"(loop of Henle development)|go:"GO:0097150"(neuronal stem cell population maintenance)|go:"GO:2000737"(negative regulation of stem cell differentiation)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0032495"(response to muramyl dipeptide)|go:"GO:0035909"(aorta morphogenesis)|go:"GO:0042060"(wound healing)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042491"(inner ear auditory receptor cell differentiation)|go:"GO:0043010"(camera-type eye development)|go:"GO:0045177"(apical part of cell)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045599"(negative regulation of fat cell differentiation)|reactome:R-RNO-9013149|reactome:R-RNO-9013423	-	-	-	figure legend:5-6|dataset:Affinomics - Interactions curated for the Affinomics consortium.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat-blood_vessel)|taxid:10116(Rat BLOOD VESSEL)	-	2014/11/26	2014/11/26	rogid:C9PHl4vEcRpUm3Pi+vXm58d0G3010116	rogid:TLFSAs0GTwutqJd0F/BOETzw8KE10116	intact-crc:71553D2504B1031B|rigid:ZTX8OK/ydvrlZtxU6zV7geuqSa4	false	-	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:Q63722	uniprotkb:Q07008	intact:EBI-4567800|uniprotkb:P70640	intact:EBI-9990181|uniprotkb:F1M9E7|ensembl:ENSRNOP00000026212	psi-mi:jag1_rat(display_long)|uniprotkb:Jag1(gene name)|psi-mi:Jag1(display_short)	psi-mi:notc1_rat(display_long)|uniprotkb:Notch1(gene name)|psi-mi:Notch1(display_short)	psi-mi:"MI:0813"(proximity ligation assay)	Tu et al. (2014)	pubmed:24563863|imex:IM-23320	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9990389|imex:IM-23320-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR018097|interpro:IPR011651(Notch ligand, N-terminal)|rgd:2937|refseq:NP_062020.1|interpro:IPR001774("Delta/Serrate/lag-2 (DSL) protein")|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR001007(von Willebrand factor, type C)|interpro:IPR013032(EGF-like region, conserved site)|rcsb pdb:5UK5|interpro:IPR026219|interpro:IPR009030(Growth factor, receptor)|reactome:R-RNO-9013507|interpro:IPR033108|go:"GO:0001709"(cell fate determination)|go:"GO:0001953"(negative regulation of cell-matrix adhesion)|go:"GO:0001974"(blood vessel remodeling)|go:"GO:0002011"(morphogenesis of an epithelial sheet)|go:"GO:0002456"(T cell mediated immunity)|go:"GO:0003184"(pulmonary valve morphogenesis)|go:"GO:0003215"(cardiac right ventricle morphogenesis)|go:"GO:0005112"(Notch binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0045602"(negative regulation of endothelial cell differentiation)|go:"GO:0045639"(positive regulation of myeloid cell differentiation)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045747"(positive regulation of Notch signaling pathway)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048018"(receptor ligand activity)|go:"GO:0048839"(inner ear development)|go:"GO:0060411"(cardiac septum morphogenesis)|go:"GO:0061073"(ciliary body morphogenesis)|go:"GO:0061156"(pulmonary artery morphogenesis)|go:"GO:0061309"(cardiac neural crest cell development involved in outflow tract morphogenesis)|go:"GO:0061314"(Notch signaling involved in heart development)|go:"GO:0022408"(negative regulation of cell-cell adhesion)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0061444"(endocardial cushion cell development)|go:"GO:0062043"(positive regulation of cardiac epithelial to mesenchymal transition)|go:"GO:0072006"(nephron development)|go:"GO:0072015"(glomerular visceral epithelial cell development)|go:"GO:0072017"(distal tubule development)|go:"GO:0072070"(loop of Henle development)|go:"GO:0097150"(neuronal stem cell population maintenance)|go:"GO:2000737"(negative regulation of stem cell differentiation)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0032495"(response to muramyl dipeptide)|go:"GO:0035909"(aorta morphogenesis)|go:"GO:0042060"(wound healing)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042491"(inner ear auditory receptor cell differentiation)|go:"GO:0043010"(camera-type eye development)|go:"GO:0045177"(apical part of cell)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045599"(negative regulation of fat cell differentiation)|reactome:R-RNO-9013149|reactome:R-RNO-9013423	rgd:3187|refseq:NP_001099191.1|ensembl:ENSRNOG00000019322(gene)|ensembl:ENSRNOT00000026212(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001501"(skeletal system development)|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001708"(cell fate specification)|go:"GO:0001726"(ruffle)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0001889"(liver development)|go:"GO:0001947"(heart looping)|go:"GO:0002040"(sprouting angiogenesis)|go:"GO:0002052"(positive regulation of neuroblast proliferation)|go:"GO:0002193"(MAML1-RBP-Jkappa- ICN1 complex)|go:"GO:0002437"(inflammatory response to antigenic stimulus)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0003157"(endocardium development)|go:"GO:0003160"(endocardium morphogenesis)|go:"GO:0003162"(atrioventricular node development)|go:"GO:0003169"(coronary vein morphogenesis)|go:"GO:0003180"(aortic valve morphogenesis)|go:"GO:0003181"(atrioventricular valve morphogenesis)|go:"GO:0003182"(coronary sinus valve morphogenesis)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006959"(humoral immune response)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0007221"(positive regulation of transcription of Notch receptor target)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007368"(determination of left/right symmetry)|go:"GO:0007386"(compartment pattern specification)|go:"GO:0007409"(axonogenesis)|go:"GO:0007417"(central nervous system development)|go:"GO:0007420"(brain development)|go:"GO:0007440"(foregut morphogenesis)|go:"GO:0007492"(endoderm development)|go:"GO:0007507"(heart development)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008544"(epidermis development)|go:"GO:0008593"(regulation of Notch signaling pathway)|go:"GO:0009912"(auditory receptor cell fate commitment)|go:"GO:0009986"(cell surface)|go:"GO:0010001"(glial cell differentiation)|go:"GO:0005112"(Notch binding)|go:"GO:0030513"(positive regulation of BMP signaling pathway)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0030900"(forebrain development)|go:"GO:0031012"(extracellular matrix)|go:"GO:0031069"(hair follicle morphogenesis)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0031960"(response to corticosteroid)|go:"GO:0032495"(response to muramyl dipeptide)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0035116"(embryonic hindlimb morphogenesis)|go:"GO:0035148"(tube formation)|go:"GO:0035914"(skeletal muscle cell differentiation)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042246"(tissue regeneration)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0003192"(mitral valve formation)|go:"GO:0003197"(endocardial cushion development)|go:"GO:0003198"(epithelial to mesenchymal transition involved in endocardial cushion formation)|go:"GO:0003203"(endocardial cushion morphogenesis)|go:"GO:0003207"(cardiac chamber formation)|go:"GO:0003208"(cardiac ventricle morphogenesis)|go:"GO:0003209"(cardiac atrium morphogenesis)|go:"GO:0003213"(cardiac right atrium morphogenesis)|go:"GO:0003214"(cardiac left ventricle morphogenesis)|go:"GO:0003219"(cardiac right ventricle formation)|go:"GO:0003222"(ventricular trabecula myocardium morphogenesis)|go:"GO:0003241"(growth involved in heart morphogenesis)|go:"GO:0003252"(negative regulation of cell proliferation involved in heart valve morphogenesis)|go:"GO:0003256"(regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation)|go:"GO:0003264"(regulation of cardioblast proliferation)|go:"GO:0003270"(Notch signaling pathway involved in regulation of secondary heart field cardioblast proliferation)|go:"GO:0003273"(cell migration involved in endocardial cushion formation)|go:"GO:0003332"(negative regulation of extracellular matrix constituent secretion)|go:"GO:0003344"(pericardium morphogenesis)|go:"GO:0003682"(chromatin binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0004857"(enzyme inhibitor activity)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0003184"(pulmonary valve morphogenesis)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0010812"(negative regulation of cell-substrate adhesion)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0014031"(mesenchymal cell development)|go:"GO:0014807"(regulation of somitogenesis)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0021515"(cell differentiation in spinal cord)|go:"GO:0021915"(neural tube development)|go:"GO:0030027"(lamellipodium)|go:"GO:0030154"(cell differentiation)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0030279"(negative regulation of ossification)|go:"GO:0030324"(lung development)|go:"GO:0030326"(embryonic limb morphogenesis)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0010614"(negative regulation of cardiac muscle hypertrophy)|go:"GO:0043086"(negative regulation of catalytic activity)|go:"GO:0043235"(receptor complex)|go:"GO:0045070"(positive regulation of viral genome replication)|go:"GO:0045165"(cell fate commitment)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045603"(positive regulation of endothelial cell differentiation)|go:"GO:0045607"(regulation of inner ear auditory receptor cell differentiation)|go:"GO:0045608"(negative regulation of inner ear auditory receptor cell differentiation)|go:"GO:0045618"(positive regulation of keratinocyte differentiation)|go:"GO:0045662"(negative regulation of myoblast differentiation)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045687"(positive regulation of glial cell differentiation)|go:"GO:0045747"(positive regulation of Notch signaling pathway)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045955"(negative regulation of calcium ion-dependent exocytosis)|go:"GO:0045967"(negative regulation of growth rate)|go:"GO:0046427"(positive regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0046533"(negative regulation of photoreceptor cell differentiation)|go:"GO:0046579"(positive regulation of Ras protein signal transduction)|go:"GO:0048103"(somatic stem cell division)|go:"GO:0048663"(neuron fate commitment)|go:"GO:0048708"(astrocyte differentiation)|go:"GO:0048709"(oligodendrocyte differentiation)|go:"GO:0048711"(positive regulation of astrocyte differentiation)|go:"GO:0048715"(negative regulation of oligodendrocyte differentiation)|go:"GO:0048754"(branching morphogenesis of an epithelial tube)|go:"GO:0048873"(homeostasis of number of cells within a tissue)|go:"GO:0050434"(positive regulation of viral transcription)|go:"GO:0050678"(regulation of epithelial cell proliferation)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0050767"(regulation of neurogenesis)|go:"GO:0050768"(negative regulation of neurogenesis)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0055008"(cardiac muscle tissue morphogenesis)|go:"GO:0060038"(cardiac muscle cell proliferation)|go:"GO:0060045"(positive regulation of cardiac muscle cell proliferation)|go:"GO:0060253"(negative regulation of glial cell proliferation)|go:"GO:0060271"(cilium assembly)|go:"GO:0060317"(cardiac epithelial to mesenchymal transition)|go:"GO:0060354"(negative regulation of cell adhesion molecule production)|go:"GO:0060411"(cardiac septum morphogenesis)|go:"GO:0060412"(ventricular septum morphogenesis)|go:"GO:0060528"(secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0060740"(prostate gland epithelium morphogenesis)|go:"GO:0060768"(regulation of epithelial cell proliferation involved in prostate gland development)|go:"GO:0060842"(arterial endothelial cell differentiation)|go:"GO:0060843"(venous endothelial cell differentiation)|go:"GO:0060948"(cardiac vascular smooth muscle cell development)|go:"GO:0060956"(endocardial cell differentiation)|go:"GO:0060979"(vasculogenesis involved in coronary vascular morphogenesis)|go:"GO:0060982"(coronary artery morphogenesis)|go:"GO:0061314"(Notch signaling involved in heart development)|go:"GO:0061384"(heart trabecula morphogenesis)|go:"GO:0061419"(positive regulation of transcription from RNA polymerase II promoter in response to hypoxia)|go:"GO:0062043"(positive regulation of cardiac epithelial to mesenchymal transition)|go:"GO:0070168"(negative regulation of biomineral tissue development)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070986"(left/right axis specification)|go:"GO:0071372"(cellular response to follicle-stimulating hormone stimulus)|go:"GO:0071944"(cell periphery)|go:"GO:0072017"(distal tubule development)|go:"GO:0072044"(collecting duct development)|go:"GO:0072144"(glomerular mesangial cell development)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097150"(neuronal stem cell population maintenance)|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|go:"GO:1901201"(regulation of extracellular matrix assembly)|go:"GO:1902263"(apoptotic process involved in embryonic digit morphogenesis)|go:"GO:1902339"(positive regulation of apoptotic process involved in morphogenesis)|go:"GO:1903849"(positive regulation of aorta morphogenesis)|go:"GO:2000048"(negative regulation of cell-cell adhesion mediated by cadherin)|go:"GO:2000737"(negative regulation of stem cell differentiation)|go:"GO:2000811"(negative regulation of anoikis)|go:"GO:2000974"(negative regulation of pro-B cell differentiation)|go:"GO:2001027"(negative regulation of endothelial cell chemotaxis)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR000800(Notch region)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR002110(Ankyrin)|go:"GO:0048845"(venous blood vessel morphogenesis)|interpro:IPR008297(Notch)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR010660(Notch, NOD region)|interpro:IPR011656(Notch, NODP region)|interpro:IPR013032(EGF-like region, conserved site)|interpro:IPR018097|interpro:IPR020683|interpro:IPR022362|interpro:IPR024600|interpro:IPR035993|interpro:IPR036770|rcsb pdb:4XL1|rcsb pdb:4XLW|rcsb pdb:5UK5	-	-	-	figure legend:5-3|dataset:Affinomics - Interactions curated for the Affinomics consortium.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat-blood_vessel)|taxid:10116(Rat BLOOD VESSEL)	-	2014/11/26	2014/11/26	rogid:TLFSAs0GTwutqJd0F/BOETzw8KE10116	rogid:DNIxiXSvq7GCN4Xtq95yLeKgLow10116	intact-crc:1A1DBF81C113675A|rigid:9kTrmtT2ILyIVjT0CMyB2R3XLgg	false	-	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:Q07008	uniprotkb:P97677	intact:EBI-9990181|uniprotkb:F1M9E7|ensembl:ENSRNOP00000026212	intact:EBI-9990315	psi-mi:notc1_rat(display_long)|uniprotkb:Notch1(gene name)|psi-mi:Notch1(display_short)	psi-mi:dll1_rat(display_long)|uniprotkb:Dll1(gene name)|psi-mi:Dll1(display_short)|uniprotkb:Drosophila Delta homolog 1(gene name synonym)	psi-mi:"MI:0813"(proximity ligation assay)	Tu et al. (2014)	pubmed:24563863|imex:IM-23320	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9990179|imex:IM-23320-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:3187|refseq:NP_001099191.1|ensembl:ENSRNOG00000019322(gene)|ensembl:ENSRNOT00000026212(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001501"(skeletal system development)|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001708"(cell fate specification)|go:"GO:0001726"(ruffle)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0001889"(liver development)|go:"GO:0001947"(heart looping)|go:"GO:0002040"(sprouting angiogenesis)|go:"GO:0002052"(positive regulation of neuroblast proliferation)|go:"GO:0002193"(MAML1-RBP-Jkappa- ICN1 complex)|go:"GO:0002437"(inflammatory response to antigenic stimulus)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0003157"(endocardium development)|go:"GO:0003160"(endocardium morphogenesis)|go:"GO:0003162"(atrioventricular node development)|go:"GO:0003169"(coronary vein morphogenesis)|go:"GO:0003180"(aortic valve morphogenesis)|go:"GO:0003181"(atrioventricular valve morphogenesis)|go:"GO:0003182"(coronary sinus valve morphogenesis)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006959"(humoral immune response)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0007221"(positive regulation of transcription of Notch receptor target)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007368"(determination of left/right symmetry)|go:"GO:0007386"(compartment pattern specification)|go:"GO:0007409"(axonogenesis)|go:"GO:0007417"(central nervous system development)|go:"GO:0007420"(brain development)|go:"GO:0007440"(foregut morphogenesis)|go:"GO:0007492"(endoderm development)|go:"GO:0007507"(heart development)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008544"(epidermis development)|go:"GO:0008593"(regulation of Notch signaling pathway)|go:"GO:0009912"(auditory receptor cell fate commitment)|go:"GO:0009986"(cell surface)|go:"GO:0010001"(glial cell differentiation)|go:"GO:0005112"(Notch binding)|go:"GO:0030513"(positive regulation of BMP signaling pathway)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0030900"(forebrain development)|go:"GO:0031012"(extracellular matrix)|go:"GO:0031069"(hair follicle morphogenesis)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0031960"(response to corticosteroid)|go:"GO:0032495"(response to muramyl dipeptide)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0035116"(embryonic hindlimb morphogenesis)|go:"GO:0035148"(tube formation)|go:"GO:0035914"(skeletal muscle cell differentiation)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042246"(tissue regeneration)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0003192"(mitral valve formation)|go:"GO:0003197"(endocardial cushion development)|go:"GO:0003198"(epithelial to mesenchymal transition involved in endocardial cushion formation)|go:"GO:0003203"(endocardial cushion morphogenesis)|go:"GO:0003207"(cardiac chamber formation)|go:"GO:0003208"(cardiac ventricle morphogenesis)|go:"GO:0003209"(cardiac atrium morphogenesis)|go:"GO:0003213"(cardiac right atrium morphogenesis)|go:"GO:0003214"(cardiac left ventricle morphogenesis)|go:"GO:0003219"(cardiac right ventricle formation)|go:"GO:0003222"(ventricular trabecula myocardium morphogenesis)|go:"GO:0003241"(growth involved in heart morphogenesis)|go:"GO:0003252"(negative regulation of cell proliferation involved in heart valve morphogenesis)|go:"GO:0003256"(regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation)|go:"GO:0003264"(regulation of cardioblast proliferation)|go:"GO:0003270"(Notch signaling pathway involved in regulation of secondary heart field cardioblast proliferation)|go:"GO:0003273"(cell migration involved in endocardial cushion formation)|go:"GO:0003332"(negative regulation of extracellular matrix constituent secretion)|go:"GO:0003344"(pericardium morphogenesis)|go:"GO:0003682"(chromatin binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0004857"(enzyme inhibitor activity)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0003184"(pulmonary valve morphogenesis)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0010812"(negative regulation of cell-substrate adhesion)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0014031"(mesenchymal cell development)|go:"GO:0014807"(regulation of somitogenesis)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0021515"(cell differentiation in spinal cord)|go:"GO:0021915"(neural tube development)|go:"GO:0030027"(lamellipodium)|go:"GO:0030154"(cell differentiation)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0030279"(negative regulation of ossification)|go:"GO:0030324"(lung development)|go:"GO:0030326"(embryonic limb morphogenesis)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0010614"(negative regulation of cardiac muscle hypertrophy)|go:"GO:0043086"(negative regulation of catalytic activity)|go:"GO:0043235"(receptor complex)|go:"GO:0045070"(positive regulation of viral genome replication)|go:"GO:0045165"(cell fate commitment)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045603"(positive regulation of endothelial cell differentiation)|go:"GO:0045607"(regulation of inner ear auditory receptor cell differentiation)|go:"GO:0045608"(negative regulation of inner ear auditory receptor cell differentiation)|go:"GO:0045618"(positive regulation of keratinocyte differentiation)|go:"GO:0045662"(negative regulation of myoblast differentiation)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045687"(positive regulation of glial cell differentiation)|go:"GO:0045747"(positive regulation of Notch signaling pathway)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045955"(negative regulation of calcium ion-dependent exocytosis)|go:"GO:0045967"(negative regulation of growth rate)|go:"GO:0046427"(positive regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0046533"(negative regulation of photoreceptor cell differentiation)|go:"GO:0046579"(positive regulation of Ras protein signal transduction)|go:"GO:0048103"(somatic stem cell division)|go:"GO:0048663"(neuron fate commitment)|go:"GO:0048708"(astrocyte differentiation)|go:"GO:0048709"(oligodendrocyte differentiation)|go:"GO:0048711"(positive regulation of astrocyte differentiation)|go:"GO:0048715"(negative regulation of oligodendrocyte differentiation)|go:"GO:0048754"(branching morphogenesis of an epithelial tube)|go:"GO:0048873"(homeostasis of number of cells within a tissue)|go:"GO:0050434"(positive regulation of viral transcription)|go:"GO:0050678"(regulation of epithelial cell proliferation)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0050767"(regulation of neurogenesis)|go:"GO:0050768"(negative regulation of neurogenesis)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0055008"(cardiac muscle tissue morphogenesis)|go:"GO:0060038"(cardiac muscle cell proliferation)|go:"GO:0060045"(positive regulation of cardiac muscle cell proliferation)|go:"GO:0060253"(negative regulation of glial cell proliferation)|go:"GO:0060271"(cilium assembly)|go:"GO:0060317"(cardiac epithelial to mesenchymal transition)|go:"GO:0060354"(negative regulation of cell adhesion molecule production)|go:"GO:0060411"(cardiac septum morphogenesis)|go:"GO:0060412"(ventricular septum morphogenesis)|go:"GO:0060528"(secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0060740"(prostate gland epithelium morphogenesis)|go:"GO:0060768"(regulation of epithelial cell proliferation involved in prostate gland development)|go:"GO:0060842"(arterial endothelial cell differentiation)|go:"GO:0060843"(venous endothelial cell differentiation)|go:"GO:0060948"(cardiac vascular smooth muscle cell development)|go:"GO:0060956"(endocardial cell differentiation)|go:"GO:0060979"(vasculogenesis involved in coronary vascular morphogenesis)|go:"GO:0060982"(coronary artery morphogenesis)|go:"GO:0061314"(Notch signaling involved in heart development)|go:"GO:0061384"(heart trabecula morphogenesis)|go:"GO:0061419"(positive regulation of transcription from RNA polymerase II promoter in response to hypoxia)|go:"GO:0062043"(positive regulation of cardiac epithelial to mesenchymal transition)|go:"GO:0070168"(negative regulation of biomineral tissue development)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070986"(left/right axis specification)|go:"GO:0071372"(cellular response to follicle-stimulating hormone stimulus)|go:"GO:0071944"(cell periphery)|go:"GO:0072017"(distal tubule development)|go:"GO:0072044"(collecting duct development)|go:"GO:0072144"(glomerular mesangial cell development)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097150"(neuronal stem cell population maintenance)|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|go:"GO:1901201"(regulation of extracellular matrix assembly)|go:"GO:1902263"(apoptotic process involved in embryonic digit morphogenesis)|go:"GO:1902339"(positive regulation of apoptotic process involved in morphogenesis)|go:"GO:1903849"(positive regulation of aorta morphogenesis)|go:"GO:2000048"(negative regulation of cell-cell adhesion mediated by cadherin)|go:"GO:2000737"(negative regulation of stem cell differentiation)|go:"GO:2000811"(negative regulation of anoikis)|go:"GO:2000974"(negative regulation of pro-B cell differentiation)|go:"GO:2001027"(negative regulation of endothelial cell chemotaxis)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR000800(Notch region)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR002110(Ankyrin)|go:"GO:0048845"(venous blood vessel morphogenesis)|interpro:IPR008297(Notch)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR010660(Notch, NOD region)|interpro:IPR011656(Notch, NODP region)|interpro:IPR013032(EGF-like region, conserved site)|interpro:IPR018097|interpro:IPR020683|interpro:IPR022362|interpro:IPR024600|interpro:IPR035993|interpro:IPR036770|rcsb pdb:4XL1|rcsb pdb:4XLW|rcsb pdb:5UK5	interpro:IPR001774("Delta/Serrate/lag-2 (DSL) protein")|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR018097|interpro:IPR009030(Growth factor, receptor)|interpro:IPR011651(Notch ligand, N-terminal)|rgd:70949|refseq:NP_114452.1|reactome:R-RNO-9013507|go:"GO:0060853"(Notch signaling pathway involved in arterial endothelial cell fate commitment)|go:"GO:0070986"(left/right axis specification)|go:"GO:0072006"(nephron development)|go:"GO:0072014"(proximal tubule development)|go:"GO:0009912"(auditory receptor cell fate commitment)|go:"GO:0009954"(proximal/distal pattern formation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0014002"(astrocyte development)|go:"GO:0014807"(regulation of somitogenesis)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0021510"(spinal cord development)|go:"GO:0021688"(cerebellar molecular layer formation)|go:"GO:0021693"(cerebellar Purkinje cell layer structural organization)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0030857"(negative regulation of epithelial cell differentiation)|go:"GO:0030957"(Tat protein binding)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032693"(negative regulation of interleukin-10 production)|go:"GO:0034351"(negative regulation of glial cell apoptotic process)|go:"GO:0035265"(organ growth)|go:"GO:0040008"(regulation of growth)|go:"GO:0045121"(membrane raft)|go:"GO:0072070"(loop of Henle development)|go:"GO:0072583"(clathrin-dependent endocytosis)|go:"GO:0097009"(energy homeostasis)|go:"GO:0097102"(endothelial tip cell fate specification)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097150"(neuronal stem cell population maintenance)|go:"GO:0098773"(skin epidermis development)|go:"GO:1900746"(regulation of vascular endothelial growth factor signaling pathway)|go:"GO:1903672"(positive regulation of sprouting angiogenesis)|go:"GO:2000726"(negative regulation of cardiac muscle cell differentiation)|go:"GO:0001709"(cell fate determination)|go:"GO:0001756"(somitogenesis)|go:"GO:0001757"(somite specification)|go:"GO:0001947"(heart looping)|go:"GO:0002315"(marginal zone B cell differentiation)|go:"GO:0003323"(type B pancreatic cell development)|go:"GO:0005112"(Notch binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007368"(determination of left/right symmetry)|go:"GO:0007386"(compartment pattern specification)|go:"GO:0007399"(nervous system development)|go:"GO:0008217"(regulation of blood pressure)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045605"(negative regulation of epidermal cell differentiation)|go:"GO:0045608"(negative regulation of inner ear auditory receptor cell differentiation)|go:"GO:0045638"(negative regulation of myeloid cell differentiation)|go:"GO:0045662"(negative regulation of myoblast differentiation)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045746"(negative regulation of Notch signaling pathway)|go:"GO:0045747"(positive regulation of Notch signaling pathway)|go:"GO:0045807"(positive regulation of endocytosis)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046331"(lateral inhibition)|go:"GO:0048630"(skeletal muscle tissue growth)|go:"GO:0048631"(regulation of skeletal muscle tissue growth)|go:"GO:0048633"(positive regulation of skeletal muscle tissue growth)|go:"GO:0048665"(neuron fate specification)|go:"GO:0048839"(inner ear development)|go:"GO:0050767"(regulation of neurogenesis)|go:"GO:0051302"(regulation of cell division)|go:"GO:0060041"(retina development in camera-type eye)|go:"GO:0060042"(retina morphogenesis in camera-type eye)	-	-	-	figure legend:5|dataset:Affinomics - Interactions curated for the Affinomics consortium.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat-blood_vessel)|taxid:10116(Rat BLOOD VESSEL)	-	2014/11/26	2014/11/26	rogid:DNIxiXSvq7GCN4Xtq95yLeKgLow10116	rogid:48mRxJ4yRgm+19eRJNsTLnu93C010116	intact-crc:4D2A3971AE55FE10|rigid:nmSCLis1lacgB/rPZHyUkR43s0c	false	-	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:D3ZHH1	uniprotkb:Q6MG89	intact:EBI-9990345|ensembl:ENSRNOP00000018970	intact:EBI-9990401|ensembl:ENSRNOP00000000513	psi-mi:dll4_rat(display_long)|uniprotkb:Dll4(gene name)|psi-mi:Dll4(display_short)|uniprotkb:Drosophila Delta homolog 4(gene name synonym)	psi-mi:q6mg89_rat(display_long)|uniprotkb:Notch4(gene name)|psi-mi:Notch4(display_short)|uniprotkb:Ager(gene name synonym)|uniprotkb:Btnl6(gene name synonym)|uniprotkb:Cyp21a1-ps(gene name synonym)|uniprotkb:Ng5(gene name synonym)|uniprotkb:Rnf5(gene name synonym)|uniprotkb:Stk19-ps(gene name synonym)|uniprotkb:Tnx(gene name synonym)|uniprotkb:rCG_38227(orf name)	psi-mi:"MI:0813"(proximity ligation assay)	Tu et al. (2014)	pubmed:24563863|imex:IM-23320	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9990445|imex:IM-23320-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:1309740|refseq:XP_006234827.1|ensembl:ENSRNOG00000014011(gene)|ensembl:ENSRNOT00000018970(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001525"(angiogenesis)|go:"GO:0001569"(branching involved in blood vessel morphogenesis)|go:"GO:0001974"(blood vessel remodeling)|go:"GO:0003208"(cardiac ventricle morphogenesis)|go:"GO:0003209"(cardiac atrium morphogenesis)|go:"GO:0003222"(ventricular trabecula myocardium morphogenesis)|go:"GO:0003344"(pericardium morphogenesis)|go:"GO:0005112"(Notch binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010596"(negative regulation of endothelial cell migration)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030217"(T cell differentiation)|go:"GO:0035912"(dorsal aorta morphogenesis)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|go:"GO:0043537"(negative regulation of blood vessel endothelial cell migration)|go:"GO:0044344"(cellular response to fibroblast growth factor stimulus)|go:"GO:0045746"(negative regulation of Notch signaling pathway)|go:"GO:0045747"(positive regulation of Notch signaling pathway)|go:"GO:0050767"(regulation of neurogenesis)|go:"GO:0060579"(ventral spinal cord interneuron fate commitment)|go:"GO:0061074"(regulation of neural retina development)|go:"GO:0061314"(Notch signaling involved in heart development)|go:"GO:0072554"(blood vessel lumenization)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:1903588"(negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001774("Delta/Serrate/lag-2 (DSL) protein")|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR011651(Notch ligand, N-terminal)|interpro:IPR013032(EGF-like region, conserved site)|rcsb pdb:4XL1|rcsb pdb:4XLW|reactome:R-RNO-9013507	ensembl:ENSRNOG00000000442(gene)|ensembl:ENSRNOT00000000513(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001569"(branching involved in blood vessel morphogenesis)|go:"GO:0001763"(morphogenesis of a branching structure)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0001886"(endothelial cell morphogenesis)|go:"GO:0001944"(vasculature development)|go:"GO:0005112"(Notch binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005634"(nucleus)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0008593"(regulation of Notch signaling pathway)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030879"(mammary gland development)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042060"(wound healing)|go:"GO:0045446"(endothelial cell differentiation)|go:"GO:0045602"(negative regulation of endothelial cell differentiation)|go:"GO:0045746"(negative regulation of Notch signaling pathway)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0048845"(venous blood vessel morphogenesis)|go:"GO:0060354"(negative regulation of cell adhesion molecule production)|go:"GO:0070613"(regulation of protein processing)|go:"GO:1903849"(positive regulation of aorta morphogenesis)|go:"GO:2000048"(negative regulation of cell-cell adhesion mediated by cadherin)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR000800(Notch region)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR002110(Ankyrin)|interpro:IPR008297(Notch)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR010660(Notch, NOD region)|interpro:IPR011656(Notch, NODP region)|interpro:IPR013032(EGF-like region, conserved site)|interpro:IPR018097|interpro:IPR020683|interpro:IPR022355|interpro:IPR035993|interpro:IPR036770|reactome:R-RNO-1912420|reactome:R-RNO-9013700|reactome:R-RNO-9604323|rgd:1303282|refseq:NP_001002827.1	-	-	-	figure legend:5-5|dataset:Affinomics - Interactions curated for the Affinomics consortium.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat-blood_vessel)|taxid:10116(Rat BLOOD VESSEL)	-	2014/11/26	2015/07/28	rogid:MT03/W/X8P48TZw6Av+vhRTIP8Q10116	rogid:C9PHl4vEcRpUm3Pi+vXm58d0G3010116	intact-crc:D33131A80AE4CB7B|rigid:mAxp7CgtJGNJajETqR+pe6TBYZM	false	-	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:P97677	uniprotkb:Q6MG89	intact:EBI-9990315	intact:EBI-9990401|ensembl:ENSRNOP00000000513	psi-mi:dll1_rat(display_long)|uniprotkb:Dll1(gene name)|psi-mi:Dll1(display_short)|uniprotkb:Drosophila Delta homolog 1(gene name synonym)	psi-mi:q6mg89_rat(display_long)|uniprotkb:Notch4(gene name)|psi-mi:Notch4(display_short)|uniprotkb:Ager(gene name synonym)|uniprotkb:Btnl6(gene name synonym)|uniprotkb:Cyp21a1-ps(gene name synonym)|uniprotkb:Ng5(gene name synonym)|uniprotkb:Rnf5(gene name synonym)|uniprotkb:Stk19-ps(gene name synonym)|uniprotkb:Tnx(gene name synonym)|uniprotkb:rCG_38227(orf name)	psi-mi:"MI:0813"(proximity ligation assay)	Tu et al. (2014)	pubmed:24563863|imex:IM-23320	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9990394|imex:IM-23320-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR001774("Delta/Serrate/lag-2 (DSL) protein")|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR018097|interpro:IPR009030(Growth factor, receptor)|interpro:IPR011651(Notch ligand, N-terminal)|rgd:70949|refseq:NP_114452.1|reactome:R-RNO-9013507|go:"GO:0060853"(Notch signaling pathway involved in arterial endothelial cell fate commitment)|go:"GO:0070986"(left/right axis specification)|go:"GO:0072006"(nephron development)|go:"GO:0072014"(proximal tubule development)|go:"GO:0009912"(auditory receptor cell fate commitment)|go:"GO:0009954"(proximal/distal pattern formation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0014002"(astrocyte development)|go:"GO:0014807"(regulation of somitogenesis)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0021510"(spinal cord development)|go:"GO:0021688"(cerebellar molecular layer formation)|go:"GO:0021693"(cerebellar Purkinje cell layer structural organization)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0030857"(negative regulation of epithelial cell differentiation)|go:"GO:0030957"(Tat protein binding)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032693"(negative regulation of interleukin-10 production)|go:"GO:0034351"(negative regulation of glial cell apoptotic process)|go:"GO:0035265"(organ growth)|go:"GO:0040008"(regulation of growth)|go:"GO:0045121"(membrane raft)|go:"GO:0072070"(loop of Henle development)|go:"GO:0072583"(clathrin-dependent endocytosis)|go:"GO:0097009"(energy homeostasis)|go:"GO:0097102"(endothelial tip cell fate specification)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097150"(neuronal stem cell population maintenance)|go:"GO:0098773"(skin epidermis development)|go:"GO:1900746"(regulation of vascular endothelial growth factor signaling pathway)|go:"GO:1903672"(positive regulation of sprouting angiogenesis)|go:"GO:2000726"(negative regulation of cardiac muscle cell differentiation)|go:"GO:0001709"(cell fate determination)|go:"GO:0001756"(somitogenesis)|go:"GO:0001757"(somite specification)|go:"GO:0001947"(heart looping)|go:"GO:0002315"(marginal zone B cell differentiation)|go:"GO:0003323"(type B pancreatic cell development)|go:"GO:0005112"(Notch binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007368"(determination of left/right symmetry)|go:"GO:0007386"(compartment pattern specification)|go:"GO:0007399"(nervous system development)|go:"GO:0008217"(regulation of blood pressure)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045605"(negative regulation of epidermal cell differentiation)|go:"GO:0045608"(negative regulation of inner ear auditory receptor cell differentiation)|go:"GO:0045638"(negative regulation of myeloid cell differentiation)|go:"GO:0045662"(negative regulation of myoblast differentiation)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045746"(negative regulation of Notch signaling pathway)|go:"GO:0045747"(positive regulation of Notch signaling pathway)|go:"GO:0045807"(positive regulation of endocytosis)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046331"(lateral inhibition)|go:"GO:0048630"(skeletal muscle tissue growth)|go:"GO:0048631"(regulation of skeletal muscle tissue growth)|go:"GO:0048633"(positive regulation of skeletal muscle tissue growth)|go:"GO:0048665"(neuron fate specification)|go:"GO:0048839"(inner ear development)|go:"GO:0050767"(regulation of neurogenesis)|go:"GO:0051302"(regulation of cell division)|go:"GO:0060041"(retina development in camera-type eye)|go:"GO:0060042"(retina morphogenesis in camera-type eye)	ensembl:ENSRNOG00000000442(gene)|ensembl:ENSRNOT00000000513(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001569"(branching involved in blood vessel morphogenesis)|go:"GO:0001763"(morphogenesis of a branching structure)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0001886"(endothelial cell morphogenesis)|go:"GO:0001944"(vasculature development)|go:"GO:0005112"(Notch binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005634"(nucleus)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0008593"(regulation of Notch signaling pathway)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030879"(mammary gland development)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042060"(wound healing)|go:"GO:0045446"(endothelial cell differentiation)|go:"GO:0045602"(negative regulation of endothelial cell differentiation)|go:"GO:0045746"(negative regulation of Notch signaling pathway)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0048845"(venous blood vessel morphogenesis)|go:"GO:0060354"(negative regulation of cell adhesion molecule production)|go:"GO:0070613"(regulation of protein processing)|go:"GO:1903849"(positive regulation of aorta morphogenesis)|go:"GO:2000048"(negative regulation of cell-cell adhesion mediated by cadherin)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR000800(Notch region)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR002110(Ankyrin)|interpro:IPR008297(Notch)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR010660(Notch, NOD region)|interpro:IPR011656(Notch, NODP region)|interpro:IPR013032(EGF-like region, conserved site)|interpro:IPR018097|interpro:IPR020683|interpro:IPR022355|interpro:IPR035993|interpro:IPR036770|reactome:R-RNO-1912420|reactome:R-RNO-9013700|reactome:R-RNO-9604323|rgd:1303282|refseq:NP_001002827.1	-	-	-	figure legend:5-4|dataset:Affinomics - Interactions curated for the Affinomics consortium.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat-blood_vessel)|taxid:10116(Rat BLOOD VESSEL)	-	2014/11/26	2014/11/26	rogid:48mRxJ4yRgm+19eRJNsTLnu93C010116	rogid:C9PHl4vEcRpUm3Pi+vXm58d0G3010116	intact-crc:B4CB064C2FE20327|rigid:xck8sokk6BQ42ejgjGNiV+JNMj0	false	-	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:D3ZHH1	uniprotkb:Q07008	intact:EBI-9990345|ensembl:ENSRNOP00000018970	intact:EBI-9990181|uniprotkb:F1M9E7|ensembl:ENSRNOP00000026212	psi-mi:dll4_rat(display_long)|uniprotkb:Dll4(gene name)|psi-mi:Dll4(display_short)|uniprotkb:Drosophila Delta homolog 4(gene name synonym)	psi-mi:notc1_rat(display_long)|uniprotkb:Notch1(gene name)|psi-mi:Notch1(display_short)	psi-mi:"MI:0813"(proximity ligation assay)	Tu et al. (2014)	pubmed:24563863|imex:IM-23320	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9990341|imex:IM-23320-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:1309740|refseq:XP_006234827.1|ensembl:ENSRNOG00000014011(gene)|ensembl:ENSRNOT00000018970(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001525"(angiogenesis)|go:"GO:0001569"(branching involved in blood vessel morphogenesis)|go:"GO:0001974"(blood vessel remodeling)|go:"GO:0003208"(cardiac ventricle morphogenesis)|go:"GO:0003209"(cardiac atrium morphogenesis)|go:"GO:0003222"(ventricular trabecula myocardium morphogenesis)|go:"GO:0003344"(pericardium morphogenesis)|go:"GO:0005112"(Notch binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010596"(negative regulation of endothelial cell migration)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030217"(T cell differentiation)|go:"GO:0035912"(dorsal aorta morphogenesis)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|go:"GO:0043537"(negative regulation of blood vessel endothelial cell migration)|go:"GO:0044344"(cellular response to fibroblast growth factor stimulus)|go:"GO:0045746"(negative regulation of Notch signaling pathway)|go:"GO:0045747"(positive regulation of Notch signaling pathway)|go:"GO:0050767"(regulation of neurogenesis)|go:"GO:0060579"(ventral spinal cord interneuron fate commitment)|go:"GO:0061074"(regulation of neural retina development)|go:"GO:0061314"(Notch signaling involved in heart development)|go:"GO:0072554"(blood vessel lumenization)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:1903588"(negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001774("Delta/Serrate/lag-2 (DSL) protein")|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR011651(Notch ligand, N-terminal)|interpro:IPR013032(EGF-like region, conserved site)|rcsb pdb:4XL1|rcsb pdb:4XLW|reactome:R-RNO-9013507	rgd:3187|refseq:NP_001099191.1|ensembl:ENSRNOG00000019322(gene)|ensembl:ENSRNOT00000026212(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001501"(skeletal system development)|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001708"(cell fate specification)|go:"GO:0001726"(ruffle)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0001889"(liver development)|go:"GO:0001947"(heart looping)|go:"GO:0002040"(sprouting angiogenesis)|go:"GO:0002052"(positive regulation of neuroblast proliferation)|go:"GO:0002193"(MAML1-RBP-Jkappa- ICN1 complex)|go:"GO:0002437"(inflammatory response to antigenic stimulus)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0003157"(endocardium development)|go:"GO:0003160"(endocardium morphogenesis)|go:"GO:0003162"(atrioventricular node development)|go:"GO:0003169"(coronary vein morphogenesis)|go:"GO:0003180"(aortic valve morphogenesis)|go:"GO:0003181"(atrioventricular valve morphogenesis)|go:"GO:0003182"(coronary sinus valve morphogenesis)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006959"(humoral immune response)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0007221"(positive regulation of transcription of Notch receptor target)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007368"(determination of left/right symmetry)|go:"GO:0007386"(compartment pattern specification)|go:"GO:0007409"(axonogenesis)|go:"GO:0007417"(central nervous system development)|go:"GO:0007420"(brain development)|go:"GO:0007440"(foregut morphogenesis)|go:"GO:0007492"(endoderm development)|go:"GO:0007507"(heart development)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008544"(epidermis development)|go:"GO:0008593"(regulation of Notch signaling pathway)|go:"GO:0009912"(auditory receptor cell fate commitment)|go:"GO:0009986"(cell surface)|go:"GO:0010001"(glial cell differentiation)|go:"GO:0005112"(Notch binding)|go:"GO:0030513"(positive regulation of BMP signaling pathway)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0030900"(forebrain development)|go:"GO:0031012"(extracellular matrix)|go:"GO:0031069"(hair follicle morphogenesis)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0031960"(response to corticosteroid)|go:"GO:0032495"(response to muramyl dipeptide)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0035116"(embryonic hindlimb morphogenesis)|go:"GO:0035148"(tube formation)|go:"GO:0035914"(skeletal muscle cell differentiation)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042246"(tissue regeneration)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0003192"(mitral valve formation)|go:"GO:0003197"(endocardial cushion development)|go:"GO:0003198"(epithelial to mesenchymal transition involved in endocardial cushion formation)|go:"GO:0003203"(endocardial cushion morphogenesis)|go:"GO:0003207"(cardiac chamber formation)|go:"GO:0003208"(cardiac ventricle morphogenesis)|go:"GO:0003209"(cardiac atrium morphogenesis)|go:"GO:0003213"(cardiac right atrium morphogenesis)|go:"GO:0003214"(cardiac left ventricle morphogenesis)|go:"GO:0003219"(cardiac right ventricle formation)|go:"GO:0003222"(ventricular trabecula myocardium morphogenesis)|go:"GO:0003241"(growth involved in heart morphogenesis)|go:"GO:0003252"(negative regulation of cell proliferation involved in heart valve morphogenesis)|go:"GO:0003256"(regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation)|go:"GO:0003264"(regulation of cardioblast proliferation)|go:"GO:0003270"(Notch signaling pathway involved in regulation of secondary heart field cardioblast proliferation)|go:"GO:0003273"(cell migration involved in endocardial cushion formation)|go:"GO:0003332"(negative regulation of extracellular matrix constituent secretion)|go:"GO:0003344"(pericardium morphogenesis)|go:"GO:0003682"(chromatin binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0004857"(enzyme inhibitor activity)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0003184"(pulmonary valve morphogenesis)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0010812"(negative regulation of cell-substrate adhesion)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0014031"(mesenchymal cell development)|go:"GO:0014807"(regulation of somitogenesis)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0021515"(cell differentiation in spinal cord)|go:"GO:0021915"(neural tube development)|go:"GO:0030027"(lamellipodium)|go:"GO:0030154"(cell differentiation)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0030279"(negative regulation of ossification)|go:"GO:0030324"(lung development)|go:"GO:0030326"(embryonic limb morphogenesis)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0010614"(negative regulation of cardiac muscle hypertrophy)|go:"GO:0043086"(negative regulation of catalytic activity)|go:"GO:0043235"(receptor complex)|go:"GO:0045070"(positive regulation of viral genome replication)|go:"GO:0045165"(cell fate commitment)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045603"(positive regulation of endothelial cell differentiation)|go:"GO:0045607"(regulation of inner ear auditory receptor cell differentiation)|go:"GO:0045608"(negative regulation of inner ear auditory receptor cell differentiation)|go:"GO:0045618"(positive regulation of keratinocyte differentiation)|go:"GO:0045662"(negative regulation of myoblast differentiation)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045687"(positive regulation of glial cell differentiation)|go:"GO:0045747"(positive regulation of Notch signaling pathway)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045955"(negative regulation of calcium ion-dependent exocytosis)|go:"GO:0045967"(negative regulation of growth rate)|go:"GO:0046427"(positive regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0046533"(negative regulation of photoreceptor cell differentiation)|go:"GO:0046579"(positive regulation of Ras protein signal transduction)|go:"GO:0048103"(somatic stem cell division)|go:"GO:0048663"(neuron fate commitment)|go:"GO:0048708"(astrocyte differentiation)|go:"GO:0048709"(oligodendrocyte differentiation)|go:"GO:0048711"(positive regulation of astrocyte differentiation)|go:"GO:0048715"(negative regulation of oligodendrocyte differentiation)|go:"GO:0048754"(branching morphogenesis of an epithelial tube)|go:"GO:0048873"(homeostasis of number of cells within a tissue)|go:"GO:0050434"(positive regulation of viral transcription)|go:"GO:0050678"(regulation of epithelial cell proliferation)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0050767"(regulation of neurogenesis)|go:"GO:0050768"(negative regulation of neurogenesis)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0055008"(cardiac muscle tissue morphogenesis)|go:"GO:0060038"(cardiac muscle cell proliferation)|go:"GO:0060045"(positive regulation of cardiac muscle cell proliferation)|go:"GO:0060253"(negative regulation of glial cell proliferation)|go:"GO:0060271"(cilium assembly)|go:"GO:0060317"(cardiac epithelial to mesenchymal transition)|go:"GO:0060354"(negative regulation of cell adhesion molecule production)|go:"GO:0060411"(cardiac septum morphogenesis)|go:"GO:0060412"(ventricular septum morphogenesis)|go:"GO:0060528"(secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0060740"(prostate gland epithelium morphogenesis)|go:"GO:0060768"(regulation of epithelial cell proliferation involved in prostate gland development)|go:"GO:0060842"(arterial endothelial cell differentiation)|go:"GO:0060843"(venous endothelial cell differentiation)|go:"GO:0060948"(cardiac vascular smooth muscle cell development)|go:"GO:0060956"(endocardial cell differentiation)|go:"GO:0060979"(vasculogenesis involved in coronary vascular morphogenesis)|go:"GO:0060982"(coronary artery morphogenesis)|go:"GO:0061314"(Notch signaling involved in heart development)|go:"GO:0061384"(heart trabecula morphogenesis)|go:"GO:0061419"(positive regulation of transcription from RNA polymerase II promoter in response to hypoxia)|go:"GO:0062043"(positive regulation of cardiac epithelial to mesenchymal transition)|go:"GO:0070168"(negative regulation of biomineral tissue development)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070986"(left/right axis specification)|go:"GO:0071372"(cellular response to follicle-stimulating hormone stimulus)|go:"GO:0071944"(cell periphery)|go:"GO:0072017"(distal tubule development)|go:"GO:0072044"(collecting duct development)|go:"GO:0072144"(glomerular mesangial cell development)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097150"(neuronal stem cell population maintenance)|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|go:"GO:1901201"(regulation of extracellular matrix assembly)|go:"GO:1902263"(apoptotic process involved in embryonic digit morphogenesis)|go:"GO:1902339"(positive regulation of apoptotic process involved in morphogenesis)|go:"GO:1903849"(positive regulation of aorta morphogenesis)|go:"GO:2000048"(negative regulation of cell-cell adhesion mediated by cadherin)|go:"GO:2000737"(negative regulation of stem cell differentiation)|go:"GO:2000811"(negative regulation of anoikis)|go:"GO:2000974"(negative regulation of pro-B cell differentiation)|go:"GO:2001027"(negative regulation of endothelial cell chemotaxis)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR000800(Notch region)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR002110(Ankyrin)|go:"GO:0048845"(venous blood vessel morphogenesis)|interpro:IPR008297(Notch)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR010660(Notch, NOD region)|interpro:IPR011656(Notch, NODP region)|interpro:IPR013032(EGF-like region, conserved site)|interpro:IPR018097|interpro:IPR020683|interpro:IPR022362|interpro:IPR024600|interpro:IPR035993|interpro:IPR036770|rcsb pdb:4XL1|rcsb pdb:4XLW|rcsb pdb:5UK5	-	-	-	figure legend:5-2|dataset:Affinomics - Interactions curated for the Affinomics consortium.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat-blood_vessel)|taxid:10116(Rat BLOOD VESSEL)	-	2014/11/26	2015/07/28	rogid:MT03/W/X8P48TZw6Av+vhRTIP8Q10116	rogid:DNIxiXSvq7GCN4Xtq95yLeKgLow10116	intact-crc:DB555B9A3971AE55|rigid:wiQPHVLHpuXoqbV52dOlbf1FHT8	false	-	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)