#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P48431	uniprotkb:P41743	intact:EBI-6124081|uniprotkb:Q14537|ensembl:ENSP00000323588	intact:EBI-286199|uniprotkb:Q8WW06|uniprotkb:D3DNQ4|ensembl:ENSP00000295797	psi-mi:sox2_human(display_long)|uniprotkb:SOX2(gene name)|psi-mi:SOX2(display_short)	psi-mi:kpci_human(display_long)|uniprotkb:nPKC-iota(gene name synonym)|uniprotkb:Atypical protein kinase C-lambda/iota(gene name synonym)|uniprotkb:PRKCI(gene name)|psi-mi:PRKCI(display_short)|uniprotkb:DXS1179E(gene name synonym)	psi-mi:"MI:0424"(protein kinase assay)	Justilien et al. (2014)	imex:IM-22238|pubmed:24525231	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9251550|imex:IM-22238-1	-	-	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_003097.1|dip:DIP-59913N|ensembl:ENSG00000181449(gene)|ensembl:ENST00000325404(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001654"(eye development)|go:"GO:0001714"(endodermal cell fate specification)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0009611"(response to wounding)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0021781"(glial cell fate commitment)|go:"GO:0021983"(pituitary gland development)|go:"GO:0021984"(adenohypophysis development)|go:"GO:0022409"(positive regulation of cell-cell adhesion)|go:"GO:0030154"(cell differentiation)|go:"GO:0030900"(forebrain development)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0035198"(miRNA binding)|go:"GO:0042246"(tissue regeneration)|go:"GO:0043281"(regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045165"(cell fate commitment)|go:"GO:0045597"(positive regulation of cell differentiation)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048839"(inner ear development)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070848"(response to growth factor)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097150"(neuronal stem cell population maintenance)|interpro:IPR009071(High mobility group box, HMG)|interpro:IPR022097|interpro:IPR032643|interpro:IPR036910|mint:P48431|rcsb pdb:1O4X|rcsb pdb:2LE4|rcsb pdb:6T7B|rcsb pdb:6T90|rcsb pdb:6WX7|rcsb pdb:6WX8|rcsb pdb:6WX9|rcsb pdb:6YOV|reactome:R-HSA-2892245|reactome:R-HSA-2892247|reactome:R-HSA-3769402|reactome:R-HSA-452723|reactome:R-HSA-6785807|reactome:R-HSA-8986944	refseq:NP_002731.4|dip:DIP-31311N|ensembl:ENSG00000163558(gene)|ensembl:ENST00000295797(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004697"(protein kinase C activity)|go:"GO:0004698"(calcium-dependent protein kinase C activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006612"(protein targeting to membrane)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007015"(actin filament organization)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016477"(cell migration)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0031252"(cell leading edge)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0034351"(negative regulation of glial cell apoptotic process)|go:"GO:0035089"(establishment of apical/basal cell polarity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042462"(eye photoreceptor cell development)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043220"(Schmidt-Lanterman incisure)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0045171"(intercellular bridge)|go:"GO:0045197"(establishment or maintenance of epithelial cell apical/basal polarity)|go:"GO:0045216"(cell-cell junction organization)|go:"GO:0045747"(positive regulation of Notch signaling pathway)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0046872"(metal ion binding)|go:"GO:0046903"(secretion)|go:"GO:0048194"(Golgi vesicle budding)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0060252"(positive regulation of glial cell proliferation)|go:"GO:0061024"(membrane organization)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099072"(regulation of postsynaptic membrane neurotransmitter receptor levels)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:2000353"(positive regulation of endothelial cell apoptotic process)|interpro:IPR000270(Octicosapeptide/Phox/Bem1p)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR012233(Protein kinase C, zeta/iota)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR017892|interpro:IPR020454|interpro:IPR034661|interpro:IPR034877|mint:P41743|rcsb pdb:1VD2|rcsb pdb:1WMH|rcsb pdb:1ZRZ|rcsb pdb:3A8W|rcsb pdb:3A8X|rcsb pdb:3ZH8|rcsb pdb:5LI1|rcsb pdb:5LI9|rcsb pdb:5LIH|rcsb pdb:6ILZ|reactome:R-HSA-1912408|reactome:R-HSA-209543|reactome:R-HSA-420029	go:"GO:0006468"(protein phosphorylation)|go:"GO:0004672"(protein kinase activity)	-	-	figure legend:6A|resulting-ptm:P48431 phosres|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/03/04	2014/10/16	rogid:cn8gYfKDpQc8J2ygnqny32sIyyU9606	rogid:v8sZdKjtlBejk0MH/9gwOjRqy+49606	intact-crc:C54AA8DE5011A402|rigid:iIut3l+nMONV7cDIIu0iUTR1lLc	false	-	his tag:n-n	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:P41743	uniprotkb:P48431	intact:EBI-286199|uniprotkb:Q8WW06|uniprotkb:D3DNQ4|ensembl:ENSP00000295797	intact:EBI-6124081|uniprotkb:Q14537|ensembl:ENSP00000323588	psi-mi:kpci_human(display_long)|uniprotkb:nPKC-iota(gene name synonym)|uniprotkb:Atypical protein kinase C-lambda/iota(gene name synonym)|uniprotkb:PRKCI(gene name)|psi-mi:PRKCI(display_short)|uniprotkb:DXS1179E(gene name synonym)	psi-mi:sox2_human(display_long)|uniprotkb:SOX2(gene name)|psi-mi:SOX2(display_short)	psi-mi:"MI:0424"(protein kinase assay)	Justilien et al. (2014)	imex:IM-22238|pubmed:24525231	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9251576|imex:IM-22238-2	-	-	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002731.4|dip:DIP-31311N|ensembl:ENSG00000163558(gene)|ensembl:ENST00000295797(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004697"(protein kinase C activity)|go:"GO:0004698"(calcium-dependent protein kinase C activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006612"(protein targeting to membrane)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007015"(actin filament organization)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016477"(cell migration)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0031252"(cell leading edge)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0034351"(negative regulation of glial cell apoptotic process)|go:"GO:0035089"(establishment of apical/basal cell polarity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042462"(eye photoreceptor cell development)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043220"(Schmidt-Lanterman incisure)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0045171"(intercellular bridge)|go:"GO:0045197"(establishment or maintenance of epithelial cell apical/basal polarity)|go:"GO:0045216"(cell-cell junction organization)|go:"GO:0045747"(positive regulation of Notch signaling pathway)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0046872"(metal ion binding)|go:"GO:0046903"(secretion)|go:"GO:0048194"(Golgi vesicle budding)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0060252"(positive regulation of glial cell proliferation)|go:"GO:0061024"(membrane organization)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099072"(regulation of postsynaptic membrane neurotransmitter receptor levels)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:2000353"(positive regulation of endothelial cell apoptotic process)|interpro:IPR000270(Octicosapeptide/Phox/Bem1p)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR012233(Protein kinase C, zeta/iota)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR017892|interpro:IPR020454|interpro:IPR034661|interpro:IPR034877|mint:P41743|rcsb pdb:1VD2|rcsb pdb:1WMH|rcsb pdb:1ZRZ|rcsb pdb:3A8W|rcsb pdb:3A8X|rcsb pdb:3ZH8|rcsb pdb:5LI1|rcsb pdb:5LI9|rcsb pdb:5LIH|rcsb pdb:6ILZ|reactome:R-HSA-1912408|reactome:R-HSA-209543|reactome:R-HSA-420029	refseq:NP_003097.1|dip:DIP-59913N|ensembl:ENSG00000181449(gene)|ensembl:ENST00000325404(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001654"(eye development)|go:"GO:0001714"(endodermal cell fate specification)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0009611"(response to wounding)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0021781"(glial cell fate commitment)|go:"GO:0021983"(pituitary gland development)|go:"GO:0021984"(adenohypophysis development)|go:"GO:0022409"(positive regulation of cell-cell adhesion)|go:"GO:0030154"(cell differentiation)|go:"GO:0030900"(forebrain development)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0035198"(miRNA binding)|go:"GO:0042246"(tissue regeneration)|go:"GO:0043281"(regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045165"(cell fate commitment)|go:"GO:0045597"(positive regulation of cell differentiation)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048839"(inner ear development)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070848"(response to growth factor)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097150"(neuronal stem cell population maintenance)|interpro:IPR009071(High mobility group box, HMG)|interpro:IPR022097|interpro:IPR032643|interpro:IPR036910|mint:P48431|rcsb pdb:1O4X|rcsb pdb:2LE4|rcsb pdb:6T7B|rcsb pdb:6T90|rcsb pdb:6WX7|rcsb pdb:6WX8|rcsb pdb:6WX9|rcsb pdb:6YOV|reactome:R-HSA-2892245|reactome:R-HSA-2892247|reactome:R-HSA-3769402|reactome:R-HSA-452723|reactome:R-HSA-6785807|reactome:R-HSA-8986944	go:"GO:0006468"(protein phosphorylation)|go:"GO:0004672"(protein kinase activity)	-	-	figure legend:6A|resulting-ptm:P48431 phosres|resulting-ptm:P48431 thr-118 O-phospho-L-threonine|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/03/04	2014/10/16	rogid:v8sZdKjtlBejk0MH/9gwOjRqy+49606	rogid:cn8gYfKDpQc8J2ygnqny32sIyyU9606	intact-crc:1D23EFD95A780813|rigid:iIut3l+nMONV7cDIIu0iUTR1lLc	false	his tag:n-n	-	-	-	psi-mi:"MI:0102"(sequence tag identification)	psi-mi:"MI:0102"(sequence tag identification)
uniprotkb:P48431	ensembl:ENSG00000054392	intact:EBI-6124081|uniprotkb:Q14537|ensembl:ENSP00000323588	intact:EBI-9251648	psi-mi:sox2_human(display_long)|uniprotkb:SOX2(gene name)|psi-mi:SOX2(display_short)	psi-mi:hhat_human_gene(display_short)|psi-mi:ENSG00000054392(display_long)	psi-mi:"MI:0402"(chromatin immunoprecipitation assay)	Justilien et al. (2014)	imex:IM-22238|pubmed:24525231	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9251646|imex:IM-22238-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0250"(gene)	refseq:NP_003097.1|dip:DIP-59913N|ensembl:ENSG00000181449(gene)|ensembl:ENST00000325404(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001654"(eye development)|go:"GO:0001714"(endodermal cell fate specification)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0009611"(response to wounding)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0021781"(glial cell fate commitment)|go:"GO:0021983"(pituitary gland development)|go:"GO:0021984"(adenohypophysis development)|go:"GO:0022409"(positive regulation of cell-cell adhesion)|go:"GO:0030154"(cell differentiation)|go:"GO:0030900"(forebrain development)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0035198"(miRNA binding)|go:"GO:0042246"(tissue regeneration)|go:"GO:0043281"(regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045165"(cell fate commitment)|go:"GO:0045597"(positive regulation of cell differentiation)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048839"(inner ear development)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070848"(response to growth factor)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097150"(neuronal stem cell population maintenance)|interpro:IPR009071(High mobility group box, HMG)|interpro:IPR022097|interpro:IPR032643|interpro:IPR036910|mint:P48431|rcsb pdb:1O4X|rcsb pdb:2LE4|rcsb pdb:6T7B|rcsb pdb:6T90|rcsb pdb:6WX7|rcsb pdb:6WX8|rcsb pdb:6WX9|rcsb pdb:6YOV|reactome:R-HSA-2892245|reactome:R-HSA-2892247|reactome:R-HSA-3769402|reactome:R-HSA-452723|reactome:R-HSA-6785807|reactome:R-HSA-8986944	-	-	-	-	figure legend:4D|comment:PKCi knockdown reduces binding of SOX2.  SOX2 regulates HHAT promoter activity and expression by a PKCi-dependent mechanism.|causality statement:P41743 is required for binding of P48431 to ENSG00000054392|causality statement:P48431 increases expression at mRNA level of Q5VTY9|causality statement:P48431 increases expression at protein  level of Q5VTY9|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-h1299)|taxid:9606(Homo sapiens lung lymph node carcinoma)	-	2014/03/04	2014/10/16	rogid:cn8gYfKDpQc8J2ygnqny32sIyyU9606	-	intact-crc:496AC3A8EB619AE0	false	-	binding-associated region:?-?	-	-	psi-mi:"MI:1195"(quantitative pcr)	psi-mi:"MI:1195"(quantitative pcr)
uniprotkb:P48431	ensembl:ENSG00000054392	intact:EBI-6124081|uniprotkb:Q14537|ensembl:ENSP00000323588	intact:EBI-9251648	psi-mi:sox2_human(display_long)|uniprotkb:SOX2(gene name)|psi-mi:SOX2(display_short)	psi-mi:hhat_human_gene(display_short)|psi-mi:ENSG00000054392(display_long)	psi-mi:"MI:0402"(chromatin immunoprecipitation assay)	Justilien et al. (2014)	imex:IM-22238|pubmed:24525231	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9253141|imex:IM-22238-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0250"(gene)	refseq:NP_003097.1|dip:DIP-59913N|ensembl:ENSG00000181449(gene)|ensembl:ENST00000325404(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001654"(eye development)|go:"GO:0001714"(endodermal cell fate specification)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0009611"(response to wounding)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0021781"(glial cell fate commitment)|go:"GO:0021983"(pituitary gland development)|go:"GO:0021984"(adenohypophysis development)|go:"GO:0022409"(positive regulation of cell-cell adhesion)|go:"GO:0030154"(cell differentiation)|go:"GO:0030900"(forebrain development)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0035198"(miRNA binding)|go:"GO:0042246"(tissue regeneration)|go:"GO:0043281"(regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045165"(cell fate commitment)|go:"GO:0045597"(positive regulation of cell differentiation)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048839"(inner ear development)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070848"(response to growth factor)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097150"(neuronal stem cell population maintenance)|interpro:IPR009071(High mobility group box, HMG)|interpro:IPR022097|interpro:IPR032643|interpro:IPR036910|mint:P48431|rcsb pdb:1O4X|rcsb pdb:2LE4|rcsb pdb:6T7B|rcsb pdb:6T90|rcsb pdb:6WX7|rcsb pdb:6WX8|rcsb pdb:6WX9|rcsb pdb:6YOV|reactome:R-HSA-2892245|reactome:R-HSA-2892247|reactome:R-HSA-3769402|reactome:R-HSA-452723|reactome:R-HSA-6785807|reactome:R-HSA-8986944	-	-	-	-	figure legend:Supp 4D|comment:PKCi knockdown reduces binding of SOX2.  SOX2 regulates HHAT promoter activity and expression by a PKCi-dependent mechanism.|causality statement:P41743 is required for binding of P48431 to ENSG00000054392|causality statement:P48431 increases expression at mRNA level of Q5VTY9|causality statement:P48431 increases expression at protein level of Q5VTY9|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-h1703)|taxid:9606(Human Lung squamous cell carcinoma)	-	2014/03/04	2014/10/16	rogid:cn8gYfKDpQc8J2ygnqny32sIyyU9606	-	intact-crc:67BE76F0948718E6	false	-	binding-associated region:?-?	-	-	psi-mi:"MI:1195"(quantitative pcr)	psi-mi:"MI:1195"(quantitative pcr)