#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:P50148 uniprotkb:P16284 intact:EBI-3909604|uniprotkb:Q6NT27|uniprotkb:Q92471|uniprotkb:O15108|uniprotkb:Q9BZB9|uniprotkb:Q13462|ensembl:ENSP00000286548 intact:EBI-716404|uniprotkb:Q6LDA9|uniprotkb:Q8TBH1|uniprotkb:Q96RF5|uniprotkb:Q96RF6|uniprotkb:Q9NP65|uniprotkb:Q9NPB7|uniprotkb:Q9NPG9|uniprotkb:Q9NQS9|uniprotkb:Q9NQT0|uniprotkb:Q9NQT1|uniprotkb:Q9NQT2|ensembl:ENSP00000457421|uniprotkb:A8K3S7|uniprotkb:D3DU31|uniprotkb:A0A075B738 psi-mi:gnaq_human(display_long)|uniprotkb:GNAQ(gene name)|psi-mi:GNAQ(display_short)|uniprotkb:GAQ(gene name synonym)|uniprotkb:Guanine nucleotide-binding protein alpha-q(gene name synonym) psi-mi:peca1_human(display_long)|uniprotkb:PECA1(gene name synonym)|uniprotkb:EndoCAM(gene name synonym)|uniprotkb:GPIIA'(gene name synonym)|uniprotkb:PECAM1(gene name)|psi-mi:PECAM1(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) dela et al. (2014) pubmed:24497640|imex:IM-23309 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-9984652|imex:IM-23309-1 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_002063.2|ensembl:ENSG00000156052(gene)|ensembl:ENST00000286548(transcript)|go:"GO:0001508"(action potential)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0001750"(photoreceptor outer segment)|go:"GO:0003924"(GTPase activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005834"(heterotrimeric G-protein complex)|go:"GO:0005886"(plasma membrane)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0007188"(adenylate cyclase-modulating G protein-coupled receptor signaling pathway)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007202"(activation of phospholipase C activity)|go:"GO:0007213"(G protein-coupled acetylcholine receptor signaling pathway)|go:"GO:0007215"(glutamate receptor signaling pathway)|go:"GO:0007596"(blood coagulation)|go:"GO:0007603"(phototransduction, visible light)|go:"GO:0009649"(entrainment of circadian clock)|go:"GO:0031683"(G-protein beta/gamma-subunit complex binding)|go:"GO:0031826"(type 2A serotonin receptor binding)|go:"GO:0031965"(nuclear membrane)|go:"GO:0045202"(synapse)|go:"GO:0046872"(metal ion binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0060828"(regulation of canonical Wnt signaling pathway)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000654(G-protein alpha subunit, group Q)|interpro:IPR001019("Guanine nucleotide binding protein (G-protein), alpha subunit")|interpro:IPR011025(G protein alpha subunit, helical insertion)|interpro:IPR027417|mint:P50148|rcsb pdb:6VU5|reactome:R-HSA-112043|reactome:R-HSA-202040|reactome:R-HSA-399997|reactome:R-HSA-416476|reactome:R-HSA-418592|reactome:R-HSA-428930|reactome:R-HSA-434316|reactome:R-HSA-456926|reactome:R-HSA-6814122|dip:DIP-41652N refseq:NP_000433.4|ensembl:ENSG00000261371(gene)|ensembl:ENST00000563924(transcript)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006909"(phagocytosis)|go:"GO:0007156"(homophilic cell adhesion via plasma membrane adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0008037"(cell recognition)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0031092"(platelet alpha granule membrane)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035633"(maintenance of blood-brain barrier)|go:"GO:0035696"(monocyte extravasation)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045121"(membrane raft)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050904"(diapedesis)|go:"GO:0061028"(establishment of endothelial barrier)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070830"(bicellular tight junction assembly)|go:"GO:0072011"(glomerular endothelium development)|go:"GO:0072672"(neutrophil extravasation)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098742"(cell-cell adhesion via plasma-membrane adhesion molecules)|go:"GO:0150107"(positive regulation of protein localization to cell-cell junction)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|interpro:IPR040878|rcsb pdb:2KY5|rcsb pdb:5C14|rcsb pdb:5GNI|reactome:R-HSA-114608|reactome:R-HSA-202733|reactome:R-HSA-210990|reactome:R-HSA-216083|reactome:R-HSA-432142|reactome:R-HSA-6798695|refseq:XP_005276937.1|refseq:XP_005276938.1|refseq:XP_005276939.1|refseq:XP_011523191.1|refseq:XP_011523192.1|refseq:XP_016880227.1|refseq:XP_016880228.1|refseq:XP_016880229.1 - - - antagonist:"Surfen ( a small molecule heparan sulfate antagonist)"|antagonist:Heparinase III|figure legend:1A/B/C/D|antagonist:Heparin|dataset:Affinomics - Interactions curated for the Affinomics consortium.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2014/11/24 2018/04/06 rogid:ExDRSmmaTXllLWSDrc79rkxxAqQ9606 rogid:Rno8MNcOwnEuSww3HPKwGZQQjXc9606 intact-crc:B30D68B846A9566D|rigid:hPlbkb1ntNcB2Nvaodpb7qlhr58 false - flag tag:c-c|mutation decreasing interaction strength:176-176,179-179|mutation decreasing interaction strength:176-176|mutation decreasing interaction strength:179-179|mutation decreasing interaction strength:179-179,239-239,176-176|mutation disrupting interaction strength:176-176,179-179,239-239,255-255 - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:P25106 uniprotkb:P16284 intact:EBI-1965291|uniprotkb:A8K6J4|intact:EBI-2839036|uniprotkb:Q53RV4|uniprotkb:Q8NE10|uniprotkb:Q92986|uniprotkb:Q92938|ensembl:ENSP00000272928 intact:EBI-716404|uniprotkb:Q6LDA9|uniprotkb:Q8TBH1|uniprotkb:Q96RF5|uniprotkb:Q96RF6|uniprotkb:Q9NP65|uniprotkb:Q9NPB7|uniprotkb:Q9NPG9|uniprotkb:Q9NQS9|uniprotkb:Q9NQT0|uniprotkb:Q9NQT1|uniprotkb:Q9NQT2|ensembl:ENSP00000457421|uniprotkb:A8K3S7|uniprotkb:D3DU31|uniprotkb:A0A075B738 psi-mi:ackr3_human(display_long)|uniprotkb:ACKR3(gene name)|psi-mi:ACKR3(display_short)|uniprotkb:C-X-C chemokine receptor type 7(gene name synonym)|uniprotkb:CMKOR1(gene name synonym)|uniprotkb:CXCR7(gene name synonym)|uniprotkb:Chemokine orphan receptor 1(gene name synonym)|uniprotkb:G-protein coupled receptor 159(gene name synonym)|uniprotkb:G-protein coupled receptor RDC1 homolog(gene name synonym)|uniprotkb:GPR159(gene name synonym)|uniprotkb:RDC1(gene name synonym) psi-mi:peca1_human(display_long)|uniprotkb:PECA1(gene name synonym)|uniprotkb:EndoCAM(gene name synonym)|uniprotkb:GPIIA'(gene name synonym)|uniprotkb:PECAM1(gene name)|psi-mi:PECAM1(display_short) psi-mi:"MI:0813"(proximity ligation assay) dela et al. (2014) pubmed:24497640|imex:IM-23309 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0469"(IntAct) intact:EBI-9984747|imex:IM-23309-6 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:XP_016860005.1|refseq:NP_064707.1|refseq:XP_005246154.1|refseq:XP_005246155.1|ensembl:ENSG00000144476(gene)|ensembl:ENST00000272928(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001570"(vasculogenesis)|go:"GO:0005044"(scavenger receptor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006955"(immune response)|go:"GO:0007155"(cell adhesion)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0015026"(coreceptor activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016493"(C-C chemokine receptor activity)|go:"GO:0016494"(C-X-C chemokine receptor activity)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019957"(C-C chemokine binding)|go:"GO:0019958"(C-X-C chemokine binding)|go:"GO:0031623"(receptor internalization)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0055037"(recycling endosome)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0070098"(chemokine-mediated signaling pathway)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:1902230"(negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:1905322"(positive regulation of mesenchymal stem cell migration)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR001416(RDC1 orphan receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|rcsb pdb:6K3F|reactome:R-HSA-380108|reactome:R-HSA-418594 refseq:NP_000433.4|ensembl:ENSG00000261371(gene)|ensembl:ENST00000563924(transcript)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006909"(phagocytosis)|go:"GO:0007156"(homophilic cell adhesion via plasma membrane adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0008037"(cell recognition)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0031092"(platelet alpha granule membrane)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035633"(maintenance of blood-brain barrier)|go:"GO:0035696"(monocyte extravasation)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045121"(membrane raft)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050904"(diapedesis)|go:"GO:0061028"(establishment of endothelial barrier)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070830"(bicellular tight junction assembly)|go:"GO:0072011"(glomerular endothelium development)|go:"GO:0072672"(neutrophil extravasation)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098742"(cell-cell adhesion via plasma-membrane adhesion molecules)|go:"GO:0150107"(positive regulation of protein localization to cell-cell junction)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|interpro:IPR040878|rcsb pdb:2KY5|rcsb pdb:5C14|rcsb pdb:5GNI|reactome:R-HSA-114608|reactome:R-HSA-202733|reactome:R-HSA-210990|reactome:R-HSA-216083|reactome:R-HSA-432142|reactome:R-HSA-6798695|refseq:XP_005276937.1|refseq:XP_005276938.1|refseq:XP_005276939.1|refseq:XP_011523191.1|refseq:XP_011523192.1|refseq:XP_016880227.1|refseq:XP_016880228.1|refseq:XP_016880229.1 go:"GO:0030054"(cell junction) - - figure legend:4C|dataset:Affinomics - Interactions curated for the Affinomics consortium.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-hcaec)|taxid:9606(human coronary artery endothelial cells) - 2014/11/24 2018/04/06 rogid:pELQ/+pDL3eQ+abxFpwYRKBPwrI9606 rogid:Rno8MNcOwnEuSww3HPKwGZQQjXc9606 intact-crc:8D5350E46ABD6D52|rigid:+aRC4z2SEqCMW+gvdY3NCsRxkBI false - - - - psi-mi:"MI:0421"(identification by antibody) psi-mi:"MI:0421"(identification by antibody) uniprotkb:P16284 uniprotkb:P18827 intact:EBI-716404|uniprotkb:Q6LDA9|uniprotkb:Q8TBH1|uniprotkb:Q96RF5|uniprotkb:Q96RF6|uniprotkb:Q9NP65|uniprotkb:Q9NPB7|uniprotkb:Q9NPG9|uniprotkb:Q9NQS9|uniprotkb:Q9NQT0|uniprotkb:Q9NQT1|uniprotkb:Q9NQT2|ensembl:ENSP00000457421|uniprotkb:A8K3S7|uniprotkb:D3DU31|uniprotkb:A0A075B738 intact:EBI-2855248|uniprotkb:Q53QV0|uniprotkb:Q96HB7|uniprotkb:Q546D3|uniprotkb:D6W523|ensembl:ENSP00000254351|ensembl:ENSP00000370542 psi-mi:peca1_human(display_long)|uniprotkb:PECA1(gene name synonym)|uniprotkb:EndoCAM(gene name synonym)|uniprotkb:GPIIA'(gene name synonym)|uniprotkb:PECAM1(gene name)|psi-mi:PECAM1(display_short) psi-mi:sdc1_human(display_long)|uniprotkb:SDC1(gene name)|psi-mi:SDC1(display_short)|uniprotkb:SDC(gene name synonym) psi-mi:"MI:0813"(proximity ligation assay) dela et al. (2014) pubmed:24497640|imex:IM-23309 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0469"(IntAct) intact:EBI-9984741|imex:IM-23309-5 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_000433.4|ensembl:ENSG00000261371(gene)|ensembl:ENST00000563924(transcript)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006909"(phagocytosis)|go:"GO:0007156"(homophilic cell adhesion via plasma membrane adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0008037"(cell recognition)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0031092"(platelet alpha granule membrane)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035633"(maintenance of blood-brain barrier)|go:"GO:0035696"(monocyte extravasation)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045121"(membrane raft)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050904"(diapedesis)|go:"GO:0061028"(establishment of endothelial barrier)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070830"(bicellular tight junction assembly)|go:"GO:0072011"(glomerular endothelium development)|go:"GO:0072672"(neutrophil extravasation)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098742"(cell-cell adhesion via plasma-membrane adhesion molecules)|go:"GO:0150107"(positive regulation of protein localization to cell-cell junction)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|interpro:IPR040878|rcsb pdb:2KY5|rcsb pdb:5C14|rcsb pdb:5GNI|reactome:R-HSA-114608|reactome:R-HSA-202733|reactome:R-HSA-210990|reactome:R-HSA-216083|reactome:R-HSA-432142|reactome:R-HSA-6798695|refseq:XP_005276937.1|refseq:XP_005276938.1|refseq:XP_005276939.1|refseq:XP_011523191.1|refseq:XP_011523192.1|refseq:XP_016880227.1|refseq:XP_016880228.1|refseq:XP_016880229.1 refseq:NP_001006947.1|refseq:NP_002988.3|dip:DIP-1123N|ensembl:ENSG00000115884(gene)|ensembl:ENST00000254351(transcript)|ensembl:ENST00000381150(transcript)|go:"GO:0001657"(ureteric bud development)|go:"GO:0005796"(Golgi lumen)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0009636"(response to toxic substance)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0016477"(cell migration)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042060"(wound healing)|go:"GO:0042802"(identical protein binding)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0048627"(myoblast development)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0051591"(response to cAMP)|go:"GO:0051592"(response to calcium ion)|go:"GO:0055002"(striated muscle cell development)|go:"GO:0060009"(Sertoli cell development)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0070062"(extracellular exosome)|go:"GO:1903543"(positive regulation of exosomal secretion)|go:"GO:1903553"(positive regulation of extracellular exosome assembly)|interpro:IPR001050(Syndecan)|interpro:IPR003585(Neurexin/syndecan/glycophorin C)|interpro:IPR027789|interpro:IPR030479|interpro:IPR031190|mint:P18827|rcsb pdb:4GVC|rcsb pdb:4GVD|rcsb pdb:6EJE|reactome:R-HSA-1971475|reactome:R-HSA-2022928|reactome:R-HSA-2024096|reactome:R-HSA-202733|reactome:R-HSA-3000170|reactome:R-HSA-3560783|reactome:R-HSA-3560801|reactome:R-HSA-3656237|reactome:R-HSA-3656253|reactome:R-HSA-4420332|reactome:R-HSA-449836|reactome:R-HSA-975634|go:"GO:0042476"(odontogenesis)|go:"GO:0042542"(response to hydrogen peroxide) go:"GO:0030054"(cell junction) - - figure legend:3B, 4A|dataset:Affinomics - Interactions curated for the Affinomics consortium.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-hcaec)|taxid:9606(human coronary artery endothelial cells) - 2014/11/24 2018/04/06 rogid:Rno8MNcOwnEuSww3HPKwGZQQjXc9606 rogid:SyiC0eBqj/X5xsWqRy9EWDxlmH09606 intact-crc:0259D7660B507707|rigid:kytVtzKdqxZFAGzkSn6sOFSGhWw false - - - - psi-mi:"MI:0421"(identification by antibody) psi-mi:"MI:0421"(identification by antibody) uniprotkb:P35052 uniprotkb:P16284 intact:EBI-8307554|ensembl:ENSP00000264039|intact:UNK-5376584|uniprotkb:Q53QM4|intact:UNK-5431308|uniprotkb:B3KTD1 intact:EBI-716404|uniprotkb:Q6LDA9|uniprotkb:Q8TBH1|uniprotkb:Q96RF5|uniprotkb:Q96RF6|uniprotkb:Q9NP65|uniprotkb:Q9NPB7|uniprotkb:Q9NPG9|uniprotkb:Q9NQS9|uniprotkb:Q9NQT0|uniprotkb:Q9NQT1|uniprotkb:Q9NQT2|ensembl:ENSP00000457421|uniprotkb:A8K3S7|uniprotkb:D3DU31|uniprotkb:A0A075B738 psi-mi:gpc1_human(display_long)|uniprotkb:GPC1(gene name)|psi-mi:GPC1(display_short) psi-mi:peca1_human(display_long)|uniprotkb:PECA1(gene name synonym)|uniprotkb:EndoCAM(gene name synonym)|uniprotkb:GPIIA'(gene name synonym)|uniprotkb:PECAM1(gene name)|psi-mi:PECAM1(display_short) psi-mi:"MI:0813"(proximity ligation assay) dela et al. (2014) pubmed:24497640|imex:IM-23309 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0469"(IntAct) intact:EBI-9984727|imex:IM-23309-4 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000063660(gene)|ensembl:ENST00000264039(transcript)|go:"GO:0005507"(copper ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005796"(Golgi lumen)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0014037"(Schwann cell differentiation)|go:"GO:0016477"(cell migration)|go:"GO:0017134"(fibroblast growth factor binding)|go:"GO:0030200"(heparan sulfate proteoglycan catabolic process)|go:"GO:0031012"(extracellular matrix)|go:"GO:0031226"(intrinsic component of plasma membrane)|go:"GO:0032288"(myelin assembly)|go:"GO:0040037"(negative regulation of fibroblast growth factor receptor signaling pathway)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043236"(laminin binding)|go:"GO:0045121"(membrane raft)|reactome:R-HSA-2024096|reactome:R-HSA-202733|reactome:R-HSA-3560783|reactome:R-HSA-3560801|reactome:R-HSA-3656237|reactome:R-HSA-3656253|reactome:R-HSA-376176|reactome:R-HSA-4420332|reactome:R-HSA-975634|go:"GO:0045202"(synapse)|go:"GO:0046658"(anchored component of plasma membrane)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:1905475"(regulation of protein localization to membrane)|go:"GO:2001016"(positive regulation of skeletal muscle cell differentiation)|interpro:IPR001863(Glypican)|interpro:IPR015502(Glypican1)|interpro:IPR019803|mint:P35052|rcsb pdb:4ACR|rcsb pdb:4AD7|rcsb pdb:4BWE|rcsb pdb:4YWT|reactome:R-HSA-1971475|reactome:R-HSA-2022928|refseq:NP_002072.2 refseq:NP_000433.4|ensembl:ENSG00000261371(gene)|ensembl:ENST00000563924(transcript)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006909"(phagocytosis)|go:"GO:0007156"(homophilic cell adhesion via plasma membrane adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0008037"(cell recognition)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0031092"(platelet alpha granule membrane)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035633"(maintenance of blood-brain barrier)|go:"GO:0035696"(monocyte extravasation)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045121"(membrane raft)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050904"(diapedesis)|go:"GO:0061028"(establishment of endothelial barrier)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070830"(bicellular tight junction assembly)|go:"GO:0072011"(glomerular endothelium development)|go:"GO:0072672"(neutrophil extravasation)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098742"(cell-cell adhesion via plasma-membrane adhesion molecules)|go:"GO:0150107"(positive regulation of protein localization to cell-cell junction)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|interpro:IPR040878|rcsb pdb:2KY5|rcsb pdb:5C14|rcsb pdb:5GNI|reactome:R-HSA-114608|reactome:R-HSA-202733|reactome:R-HSA-210990|reactome:R-HSA-216083|reactome:R-HSA-432142|reactome:R-HSA-6798695|refseq:XP_005276937.1|refseq:XP_005276938.1|refseq:XP_005276939.1|refseq:XP_011523191.1|refseq:XP_011523192.1|refseq:XP_016880227.1|refseq:XP_016880228.1|refseq:XP_016880229.1 - function:Cell surface proteoglycan that bears heparan sulfate|comment:mint - figure legend:3D|dataset:Affinomics - Interactions curated for the Affinomics consortium.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-hcaec)|taxid:9606(human coronary artery endothelial cells) - 2014/11/24 2018/04/06 rogid:ycuKz8cHA1TlfV2XkBz+onEEwyw9606 rogid:Rno8MNcOwnEuSww3HPKwGZQQjXc9606 intact-crc:817E47396928A3F4|rigid:esjyKop87O0x7jznMToj2B++JLU false - - - - psi-mi:"MI:0421"(identification by antibody) psi-mi:"MI:0421"(identification by antibody) uniprotkb:P16284 uniprotkb:P61073 intact:EBI-716404|uniprotkb:Q6LDA9|uniprotkb:Q8TBH1|uniprotkb:Q96RF5|uniprotkb:Q96RF6|uniprotkb:Q9NP65|uniprotkb:Q9NPB7|uniprotkb:Q9NPG9|uniprotkb:Q9NQS9|uniprotkb:Q9NQT0|uniprotkb:Q9NQT1|uniprotkb:Q9NQT2|ensembl:ENSP00000457421|uniprotkb:A8K3S7|uniprotkb:D3DU31|uniprotkb:A0A075B738 intact:EBI-489411|uniprotkb:Q53S69|uniprotkb:O60835|uniprotkb:P30991|uniprotkb:P56438|uniprotkb:Q9UKN2|uniprotkb:B2R5N0|uniprotkb:Q9BXA0|ensembl:ENSP00000241393 psi-mi:peca1_human(display_long)|uniprotkb:PECA1(gene name synonym)|uniprotkb:EndoCAM(gene name synonym)|uniprotkb:GPIIA'(gene name synonym)|uniprotkb:PECAM1(gene name)|psi-mi:PECAM1(display_short) psi-mi:cxcr4_human(display_long)|uniprotkb:Stromal cell-derived factor 1 receptor(gene name synonym)|uniprotkb:Fusin(gene name synonym)|uniprotkb:Leukocyte-derived seven transmembrane domain receptor(gene name synonym)|uniprotkb:LCR1(gene name synonym)|uniprotkb:FB22(gene name synonym)|uniprotkb:NPYRL(gene name synonym)|uniprotkb:HM89(gene name synonym)|uniprotkb:CXCR4(gene name)|psi-mi:CXCR4(display_short)|uniprotkb:Lipopolysaccharide-associated protein 3(gene name synonym) psi-mi:"MI:0813"(proximity ligation assay) dela et al. (2014) pubmed:24497640|imex:IM-23309 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0469"(IntAct) intact:EBI-9984719|imex:IM-23309-2 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_000433.4|ensembl:ENSG00000261371(gene)|ensembl:ENST00000563924(transcript)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006909"(phagocytosis)|go:"GO:0007156"(homophilic cell adhesion via plasma membrane adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0008037"(cell recognition)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0031092"(platelet alpha granule membrane)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035633"(maintenance of blood-brain barrier)|go:"GO:0035696"(monocyte extravasation)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045121"(membrane raft)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050904"(diapedesis)|go:"GO:0061028"(establishment of endothelial barrier)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070830"(bicellular tight junction assembly)|go:"GO:0072011"(glomerular endothelium development)|go:"GO:0072672"(neutrophil extravasation)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098742"(cell-cell adhesion via plasma-membrane adhesion molecules)|go:"GO:0150107"(positive regulation of protein localization to cell-cell junction)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|interpro:IPR040878|rcsb pdb:2KY5|rcsb pdb:5C14|rcsb pdb:5GNI|reactome:R-HSA-114608|reactome:R-HSA-202733|reactome:R-HSA-210990|reactome:R-HSA-216083|reactome:R-HSA-432142|reactome:R-HSA-6798695|refseq:XP_005276937.1|refseq:XP_005276938.1|refseq:XP_005276939.1|refseq:XP_011523191.1|refseq:XP_011523192.1|refseq:XP_016880227.1|refseq:XP_016880228.1|refseq:XP_016880229.1 refseq:NP_001008540.1|refseq:NP_003458.1|refseq:NP_001334985.1|refseq:NP_001334988.1|refseq:NP_001334989.1|dip:DIP-34773N|dip:DIP-46290N|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007420"(brain development)|go:"GO:0008038"(neuron recognition)|go:"GO:0009615"(response to virus)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0014823"(response to activity)|go:"GO:0015026"(coreceptor activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016493"(C-C chemokine receptor activity)|go:"GO:0016494"(C-X-C chemokine receptor activity)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019957"(C-C chemokine binding)|go:"GO:0022008"(neurogenesis)|go:"GO:0022029"(telencephalon cell migration)|go:"GO:0030054"(cell junction)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0031252"(cell leading edge)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032027"(myosin light chain binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035470"(positive regulation of vascular wound healing)|go:"GO:0035690"|go:"GO:0038147"(C-X-C motif chemokine 12 receptor activity)|go:"GO:0038160"(CXCL12-activated CXCR4 signaling pathway)|go:"GO:0043067"(regulation of programmed cell death)|go:"GO:0043130"(ubiquitin binding)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|interpro:IPR022726|mint:P61073|rcsb pdb:2K03|rcsb pdb:2K04|rcsb pdb:2K05|rcsb pdb:2N55|rcsb pdb:3ODU|rcsb pdb:3OE0|rcsb pdb:3OE6|rcsb pdb:3OE8|rcsb pdb:3OE9|rcsb pdb:4RWS|reactome:R-HSA-173107|reactome:R-HSA-376176|reactome:R-HSA-380108|reactome:R-HSA-418594|go:"GO:0043217"(myelin maintenance)|go:"GO:0043278"(response to morphine)|go:"GO:0045446"(endothelial cell differentiation)|go:"GO:0048714"(positive regulation of oligodendrocyte differentiation)|go:"GO:0050792"(regulation of viral process)|go:"GO:0050920"(regulation of chemotaxis)|go:"GO:0050921"(positive regulation of chemotaxis)|go:"GO:0050965"(detection of temperature stimulus involved in sensory perception of pain)|go:"GO:0050966"(detection of mechanical stimulus involved in sensory perception of pain)|go:"GO:0051924"(regulation of calcium ion transport)|go:"GO:0060048"(cardiac muscle contraction)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0061154"(endothelial tube morphogenesis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1903861"(positive regulation of dendrite extension)|go:"GO:1905322"(positive regulation of mesenchymal stem cell migration)|go:"GO:1990478"(response to ultrasound)|go:"GO:2000448"(positive regulation of macrophage migration inhibitory factor signaling pathway)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR000355(Chemokine receptor)|interpro:IPR001277(C-X-C chemokine receptor, type 4)|ensembl:ENSG00000121966(gene)|ensembl:ENST00000241393(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001618"(virus receptor activity)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001764"(neuron migration)|go:"GO:0002064"(epithelial cell development)|go:"GO:0002407"(dendritic cell chemotaxis)|go:"GO:0003779"(actin binding)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome) - - - figure legend:4B|dataset:Affinomics - Interactions curated for the Affinomics consortium.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-hcaec)|taxid:9606(human coronary artery endothelial cells) - 2014/11/24 2018/04/06 rogid:Rno8MNcOwnEuSww3HPKwGZQQjXc9606 rogid:/DC0/+M1YsFLLfsDimppXSS/vpQ9606 intact-crc:6C5073177F8DCEC7|rigid:GJW96ccL84XMaMsYUcdd64fxP/4 false - - - - psi-mi:"MI:0421"(identification by antibody) psi-mi:"MI:0421"(identification by antibody) uniprotkb:P31431 uniprotkb:P16284 intact:EBI-3913237|uniprotkb:Q16833|uniprotkb:O00773|uniprotkb:Q53FN9|uniprotkb:Q6FGN3|ensembl:ENSP00000361818 intact:EBI-716404|uniprotkb:Q6LDA9|uniprotkb:Q8TBH1|uniprotkb:Q96RF5|uniprotkb:Q96RF6|uniprotkb:Q9NP65|uniprotkb:Q9NPB7|uniprotkb:Q9NPG9|uniprotkb:Q9NQS9|uniprotkb:Q9NQT0|uniprotkb:Q9NQT1|uniprotkb:Q9NQT2|ensembl:ENSP00000457421|uniprotkb:A8K3S7|uniprotkb:D3DU31|uniprotkb:A0A075B738 psi-mi:sdc4_human(display_long)|uniprotkb:SDC4(gene name)|psi-mi:SDC4(display_short)|uniprotkb:Amphiglycan(gene name synonym)|uniprotkb:Ryudocan core protein(gene name synonym) psi-mi:peca1_human(display_long)|uniprotkb:PECA1(gene name synonym)|uniprotkb:EndoCAM(gene name synonym)|uniprotkb:GPIIA'(gene name synonym)|uniprotkb:PECAM1(gene name)|psi-mi:PECAM1(display_short) psi-mi:"MI:0813"(proximity ligation assay) dela et al. (2014) pubmed:24497640|imex:IM-23309 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:0469"(IntAct) intact:EBI-9984723|imex:IM-23309-3 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_002990.2|ensembl:ENSG00000124145(gene)|ensembl:ENST00000372733(transcript)|go:"GO:0001657"(ureteric bud development)|go:"GO:0001843"(neural tube closure)|go:"GO:0001968"(fibronectin binding)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005796"(Golgi lumen)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0009986"(cell surface)|go:"GO:0010762"(regulation of fibroblast migration)|go:"GO:0016477"(cell migration)|go:"GO:0042060"(wound healing)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043034"(costamere)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0045121"(membrane raft)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0060122"(inner ear receptor cell stereocilium organization)|go:"GO:0070053"(thrombospondin receptor activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:1903543"(positive regulation of exosomal secretion)|go:"GO:1903553"(positive regulation of extracellular exosome assembly)|interpro:IPR001050(Syndecan)|interpro:IPR003585(Neurexin/syndecan/glycophorin C)|interpro:IPR027789|interpro:IPR030479|rcsb pdb:1EJP|rcsb pdb:1EJQ|rcsb pdb:1OBY|rcsb pdb:1YBO|reactome:R-HSA-1971475|reactome:R-HSA-2022928|reactome:R-HSA-2024096|reactome:R-HSA-202733|reactome:R-HSA-3000170|reactome:R-HSA-3560783|reactome:R-HSA-3560801|reactome:R-HSA-3656237|reactome:R-HSA-3656253|reactome:R-HSA-4420332|reactome:R-HSA-975634|dip:DIP-29945N refseq:NP_000433.4|ensembl:ENSG00000261371(gene)|ensembl:ENST00000563924(transcript)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006909"(phagocytosis)|go:"GO:0007156"(homophilic cell adhesion via plasma membrane adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0008037"(cell recognition)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0031092"(platelet alpha granule membrane)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035633"(maintenance of blood-brain barrier)|go:"GO:0035696"(monocyte extravasation)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045121"(membrane raft)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050904"(diapedesis)|go:"GO:0061028"(establishment of endothelial barrier)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070830"(bicellular tight junction assembly)|go:"GO:0072011"(glomerular endothelium development)|go:"GO:0072672"(neutrophil extravasation)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098742"(cell-cell adhesion via plasma-membrane adhesion molecules)|go:"GO:0150107"(positive regulation of protein localization to cell-cell junction)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|interpro:IPR040878|rcsb pdb:2KY5|rcsb pdb:5C14|rcsb pdb:5GNI|reactome:R-HSA-114608|reactome:R-HSA-202733|reactome:R-HSA-210990|reactome:R-HSA-216083|reactome:R-HSA-432142|reactome:R-HSA-6798695|refseq:XP_005276937.1|refseq:XP_005276938.1|refseq:XP_005276939.1|refseq:XP_011523191.1|refseq:XP_011523192.1|refseq:XP_016880227.1|refseq:XP_016880228.1|refseq:XP_016880229.1 - - - figure legend:3C|dataset:Affinomics - Interactions curated for the Affinomics consortium.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-hcaec)|taxid:9606(human coronary artery endothelial cells) - 2014/11/24 2018/04/06 rogid:ggGFQ0PE+rGXSk3dHtQCgHwSjjk9606 rogid:Rno8MNcOwnEuSww3HPKwGZQQjXc9606 intact-crc:F08F3EF94AA46275|rigid:Kyv/4I6aOpCVhLzG/jADRW7suWA false - - - - psi-mi:"MI:0421"(identification by antibody) psi-mi:"MI:0421"(identification by antibody)