#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:O35505 uniprotkb:P20810 intact:EBI-9084208|uniprotkb:Q9Z305 intact:EBI-1268770|uniprotkb:G5E9D3|uniprotkb:O95360|uniprotkb:Q96D08|uniprotkb:Q9H1Z5|uniprotkb:Q7Z4K0|intact:EBI-11042429|uniprotkb:B7Z468|uniprotkb:Q05DE8|uniprotkb:G5E946|ensembl:ENSP00000339914|ensembl:ENSP00000379158 psi-mi:cac1c_cavpo(display_long)|uniprotkb:CACNA1C(gene name)|psi-mi:CACNA1C(display_short)|uniprotkb:CACH2(gene name synonym)|uniprotkb:CACN2(gene name synonym)|uniprotkb:CACNL1A1(gene name synonym)|uniprotkb:CCHL1A1(gene name synonym)|uniprotkb:Calcium channel, L type, alpha-1 polypeptide, isoform 1, cardiac muscle(gene name synonym)|uniprotkb:Voltage-gated calcium channel subunit alpha Cav1.2(gene name synonym) psi-mi:ical_human(display_long)|uniprotkb:CAST(gene name)|psi-mi:CAST(display_short)|uniprotkb:Calpain inhibitor(gene name synonym)|uniprotkb:Sperm BS-17 component(gene name synonym) psi-mi:"MI:0096"(pull down) Sun et al. (2014) pubmed:24462690|imex:IM-22078 taxid:10141(cavpo)|taxid:10141("Cavia porcellus (Guinea pig)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0471"(MINT) intact:EBI-9084237|imex:IM-22078-2 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR005446(Voltage-dependent calcium channel, L-type, alpha-1 subunit)|interpro:IPR005451(Voltage-dependent calcium channel, L-type, alpha-1C subunit)|interpro:IPR014873(Voltage-dependent calcium channel, alpha-1 subunit, IQ domain)|interpro:IPR027359|interpro:IPR031649|interpro:IPR031688|refseq:NP_001166394.1|interpro:IPR005821(Ion transport)|interpro:IPR002077(Voltage-dependent calcium channel, alpha-1 subunit)|go:"GO:0005245"(voltage-gated calcium channel activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0008331"(high voltage-gated calcium channel activity)|go:"GO:0010881"(regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion)|go:"GO:0030315"(T-tubule)|go:"GO:0030425"(dendrite)|go:"GO:0042383"(sarcolemma)|go:"GO:0043204"(perikaryon)|go:"GO:0045762"(positive regulation of adenylate cyclase activity)|go:"GO:0046872"(metal ion binding)|go:"GO:0060402"(calcium ion transport into cytosol)|go:"GO:0061337"(cardiac conduction)|go:"GO:0061577"(calcium ion transmembrane transport via high voltage-gated calcium channel)|go:"GO:0070588"(calcium ion transmembrane transport)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:1990454"(L-type voltage-gated calcium channel complex) refseq:NP_001035905.1|refseq:XP_006714759.1|refseq:XP_006714766.1|refseq:NP_001271141.1|refseq:XP_006714764.1|refseq:NP_001035906.1|refseq:NP_001035907.1|refseq:NP_001035908.1|refseq:NP_001035909.1|refseq:NP_001317560.1|refseq:NP_001741.4|refseq:XP_016865402.1|go:"GO:2000675"(negative regulation of type B pancreatic cell apoptotic process)|interpro:IPR001259(Proteinase inhibitor I27, calpastatin)|interpro:IPR026998|mint:P20810|reactome:R-HSA-1474228|reactome:R-HSA-8862803|go:"GO:1990709"(presynaptic active zone organization)|ensembl:ENSG00000153113(gene)|ensembl:ENST00000341926(transcript)|ensembl:ENST00000395813(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0004866"(endopeptidase inhibitor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0010859"(calcium-dependent cysteine-type endopeptidase inhibitor activity)|go:"GO:0016020"(membrane)|go:"GO:0045296"(cadherin binding)|go:"GO:0097340"(inhibition of cysteine-type endopeptidase activity)|refseq:NP_775083.1|refseq:XP_006714767.1 - - - figure legend:f2 f4 t1 t2|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2014/01/14 2014/10/16 rogid:hnyCg93Tv/IhpuLPHalQb5D5J4M10141 rogid:sDc8/o13gLhr18fYsz/grYg13Lo9606 intact-crc:54BCA1A08838B383|rigid:HnFSMIJUyrG/UHPCTkqQDp+/yWw false binding-associated region:1599-1639|glutathione s tranferase tag:?-?|mutation disrupting interaction:1629-1630,1618-1618,1612-1612 binding-associated region:3-148 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0818"(molecular weight estimation by coomasie staining) uniprotkb:O35505 uniprotkb:P20810 intact:EBI-9084208|uniprotkb:Q9Z305 intact:EBI-1268770|uniprotkb:G5E9D3|uniprotkb:O95360|uniprotkb:Q96D08|uniprotkb:Q9H1Z5|uniprotkb:Q7Z4K0|intact:EBI-11042429|uniprotkb:B7Z468|uniprotkb:Q05DE8|uniprotkb:G5E946|ensembl:ENSP00000339914|ensembl:ENSP00000379158 psi-mi:cac1c_cavpo(display_long)|uniprotkb:CACNA1C(gene name)|psi-mi:CACNA1C(display_short)|uniprotkb:CACH2(gene name synonym)|uniprotkb:CACN2(gene name synonym)|uniprotkb:CACNL1A1(gene name synonym)|uniprotkb:CCHL1A1(gene name synonym)|uniprotkb:Calcium channel, L type, alpha-1 polypeptide, isoform 1, cardiac muscle(gene name synonym)|uniprotkb:Voltage-gated calcium channel subunit alpha Cav1.2(gene name synonym) psi-mi:ical_human(display_long)|uniprotkb:CAST(gene name)|psi-mi:CAST(display_short)|uniprotkb:Calpain inhibitor(gene name synonym)|uniprotkb:Sperm BS-17 component(gene name synonym) psi-mi:"MI:0096"(pull down) Sun et al. (2014) pubmed:24462690|imex:IM-22078 taxid:10141(cavpo)|taxid:10141("Cavia porcellus (Guinea pig)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0471"(MINT) intact:EBI-9084206|imex:IM-22078-1 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR005446(Voltage-dependent calcium channel, L-type, alpha-1 subunit)|interpro:IPR005451(Voltage-dependent calcium channel, L-type, alpha-1C subunit)|interpro:IPR014873(Voltage-dependent calcium channel, alpha-1 subunit, IQ domain)|interpro:IPR027359|interpro:IPR031649|interpro:IPR031688|refseq:NP_001166394.1|interpro:IPR005821(Ion transport)|interpro:IPR002077(Voltage-dependent calcium channel, alpha-1 subunit)|go:"GO:0005245"(voltage-gated calcium channel activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0008331"(high voltage-gated calcium channel activity)|go:"GO:0010881"(regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion)|go:"GO:0030315"(T-tubule)|go:"GO:0030425"(dendrite)|go:"GO:0042383"(sarcolemma)|go:"GO:0043204"(perikaryon)|go:"GO:0045762"(positive regulation of adenylate cyclase activity)|go:"GO:0046872"(metal ion binding)|go:"GO:0060402"(calcium ion transport into cytosol)|go:"GO:0061337"(cardiac conduction)|go:"GO:0061577"(calcium ion transmembrane transport via high voltage-gated calcium channel)|go:"GO:0070588"(calcium ion transmembrane transport)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:1990454"(L-type voltage-gated calcium channel complex) refseq:NP_001035905.1|refseq:XP_006714759.1|refseq:XP_006714766.1|refseq:NP_001271141.1|refseq:XP_006714764.1|refseq:NP_001035906.1|refseq:NP_001035907.1|refseq:NP_001035908.1|refseq:NP_001035909.1|refseq:NP_001317560.1|refseq:NP_001741.4|refseq:XP_016865402.1|go:"GO:2000675"(negative regulation of type B pancreatic cell apoptotic process)|interpro:IPR001259(Proteinase inhibitor I27, calpastatin)|interpro:IPR026998|mint:P20810|reactome:R-HSA-1474228|reactome:R-HSA-8862803|go:"GO:1990709"(presynaptic active zone organization)|ensembl:ENSG00000153113(gene)|ensembl:ENST00000341926(transcript)|ensembl:ENST00000395813(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0004866"(endopeptidase inhibitor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0010859"(calcium-dependent cysteine-type endopeptidase inhibitor activity)|go:"GO:0016020"(membrane)|go:"GO:0045296"(cadherin binding)|go:"GO:0097340"(inhibition of cysteine-type endopeptidase activity)|refseq:NP_775083.1|refseq:XP_006714767.1 - - - figure legend:f2 f3 t1 t2|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2014/01/14 2014/10/16 rogid:hnyCg93Tv/IhpuLPHalQb5D5J4M10141 rogid:sDc8/o13gLhr18fYsz/grYg13Lo9606 intact-crc:AA0831CB4E39F748|rigid:HnFSMIJUyrG/UHPCTkqQDp+/yWw false glutathione s tranferase tag:?-?|binding-associated region:1648-1668|mutation disrupting interaction:1653-1653 binding-associated region:3-148 - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)