#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:O15519	uniprotkb:Q14790	intact:EBI-514941|ensembl:ENSP00000312455|ensembl:ENSP00000399420|uniprotkb:Q53TS6|uniprotkb:O14673|uniprotkb:O14674|uniprotkb:O14675|uniprotkb:O15137|uniprotkb:O15138|uniprotkb:O15356|uniprotkb:O15510|uniprotkb:O43618|uniprotkb:O43619|uniprotkb:O43620|uniprotkb:O60458|uniprotkb:O60459|uniprotkb:Q96TE4|uniprotkb:Q9UEW1|uniprotkb:Q54AF1|uniprotkb:B7Z9F9|uniprotkb:B4DJE0	intact:EBI-78060|ensembl:ENSP00000412523|ensembl:ENSP00000501268|uniprotkb:Q14793|uniprotkb:Q14794|uniprotkb:Q14795|uniprotkb:Q14796|uniprotkb:Q15780|uniprotkb:Q15806|uniprotkb:Q53TT5|uniprotkb:Q8TDI1|uniprotkb:Q8TDI2|uniprotkb:Q8TDI3|uniprotkb:Q8TDI4|uniprotkb:Q8TDI5|uniprotkb:Q96T22|uniprotkb:Q9C0K4|uniprotkb:O14676|uniprotkb:Q14791|uniprotkb:Q14792|uniprotkb:Q9UQ81	psi-mi:cflar_human(display_long)|uniprotkb:Cellular FLICE-like inhibitory protein(gene name synonym)|uniprotkb:Caspase-eight-related protein(gene name synonym)|uniprotkb:Caspase-like apoptosis regulatory protein(gene name synonym)|uniprotkb:MACH-related inducer of toxicity(gene name synonym)|uniprotkb:Caspase homolog(gene name synonym)|uniprotkb:Inhibitor of FLICE(gene name synonym)|uniprotkb:FADD-like antiapoptotic molecule 1(gene name synonym)|uniprotkb:Usurpin(gene name synonym)|uniprotkb:CFLAR(gene name)|psi-mi:CFLAR(display_short)|uniprotkb:CASH(gene name synonym)|uniprotkb:CLARP(gene name synonym)|uniprotkb:MRIT(gene name synonym)|uniprotkb:CASP8AP1(gene name synonym)	psi-mi:casp8_human(display_long)|uniprotkb:CASP8(gene name)|psi-mi:CASP8(display_short)|uniprotkb:MCH5(gene name synonym)|uniprotkb:ICE-like apoptotic protease 5(gene name synonym)|uniprotkb:MORT1-associated ced-3 homolog(gene name synonym)|uniprotkb:FADD-homologous ICE/ced-3-like protease(gene name synonym)|uniprotkb:FADD-like ICE(gene name synonym)|uniprotkb:Apoptotic cysteine protease(gene name synonym)|uniprotkb:Apoptotic protease Mch-5(gene name synonym)|uniprotkb:CAP4(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Cantarella et al. (2014)	pubmed:24438025|imex:IM-22082	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-9087291|imex:IM-22082-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000003402(gene)|ensembl:ENST00000309955(transcript)|ensembl:ENST00000423241(transcript)|go:"GO:0002020"(protease binding)|go:"GO:0005123"(death receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007519"(skeletal muscle tissue development)|go:"GO:0008047"(enzyme activator activity)|go:"GO:0010667"(negative regulation of cardiac muscle cell apoptotic process)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014732"(skeletal muscle atrophy)|go:"GO:0014842"(regulation of skeletal muscle satellite cell proliferation)|go:"GO:0014866"(skeletal myofibril assembly)|go:"GO:0031264"(death-inducing signaling complex)|go:"GO:0031265"(CD95 death-inducing signaling complex)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0033574"(response to testosterone)|go:"GO:0042060"(wound healing)|refseq:NP_001120655.1|refseq:NP_001120656.1|refseq:NP_001189444.1|refseq:NP_001189445.1|refseq:NP_001189446.1|refseq:NP_001189447.1|refseq:NP_001189448.1|refseq:NP_003870.4|refseq:NP_001294971.1|refseq:XP_016860681.1|refseq:XP_016860683.1|refseq:XP_016860679.1|refseq:XP_016860680.1|refseq:XP_016860682.1|refseq:XP_016860684.1|refseq:XP_016860685.1|refseq:XP_016860686.1|refseq:XP_016860687.1|dip:DIP-27629N|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043403"(skeletal muscle tissue regeneration)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0060544"(regulation of necroptotic process)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0071392"(cellular response to estradiol stimulus)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071549"(cellular response to dexamethasone stimulus)|go:"GO:0071732"(cellular response to nitric oxide)|go:"GO:0072126"(positive regulation of glomerular mesangial cell proliferation)|go:"GO:0097153"(cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0097199"(cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|go:"GO:0097200"(cysteine-type endopeptidase activity involved in execution phase of apoptosis)|go:"GO:0097342"(ripoptosome)|go:"GO:1901740"(negative regulation of myoblast fusion)|go:"GO:1902042"(negative regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1903055"(positive regulation of extracellular matrix organization)|go:"GO:1903427"(negative regulation of reactive oxygen species biosynthetic process)|go:"GO:1903845"(negative regulation of cellular response to transforming growth factor beta stimulus)|go:"GO:1903944"(negative regulation of hepatocyte apoptotic process)|go:"GO:2000347"(positive regulation of hepatocyte proliferation)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR001309(Peptidase C14, ICE, catalytic subunit p20)|interpro:IPR001875(Death effector)|interpro:IPR002398(Peptidase C14, caspase precursor p45)|interpro:IPR011029(DEATH-like)|interpro:IPR015917(Peptidase C14, caspase precursor p45, core)|interpro:IPR029030|rcsb pdb:2N5R|rcsb pdb:3H11|rcsb pdb:3H13|rcsb pdb:6M6O|reactome:R-HSA-3371378|reactome:R-HSA-5213460|reactome:R-HSA-5218900|reactome:R-HSA-5357905|reactome:R-HSA-69416|reactome:R-HSA-75158	go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007507"(heart development)|go:"GO:0008233"(peptidase activity)|go:"GO:0008234"(cysteine-type peptidase activity)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|ensembl:ENSG00000064012(gene)|ensembl:ENST00000432109(transcript)|ensembl:ENST00000673742(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001817"(regulation of cytokine production)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0005123"(death receptor binding)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006508"(proteolysis)|go:"GO:0006915"(apoptotic process)|go:"GO:0009409"(response to cold)|go:"GO:0010803"(regulation of tumor necrosis factor-mediated signaling pathway)|go:"GO:0030101"(natural killer cell activation)|go:"GO:0030225"(macrophage differentiation)|go:"GO:0031264"(death-inducing signaling complex)|go:"GO:0031265"(CD95 death-inducing signaling complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032025"(response to cobalt ion)|go:"GO:0032355"(response to estradiol)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034612"(response to tumor necrosis factor)|go:"GO:0035877"(death effector domain binding)|go:"GO:0036462"(TRAIL-activated apoptotic signaling pathway)|go:"GO:0042110"(T cell activation)|go:"GO:0042113"(B cell activation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0044297"(cell body)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045088"(regulation of innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0045651"(positive regulation of macrophage differentiation)|go:"GO:0045862"(positive regulation of proteolysis)|go:"GO:0046677"(response to antibiotic)|go:"GO:0051603"(proteolysis involved in cellular protein catabolic process)|go:"GO:0060546"(negative regulation of necroptotic process)|go:"GO:0060715"(syncytiotrophoblast cell differentiation involved in labyrinthine layer development)|go:"GO:0070269"(pyroptosis)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097153"(cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0097190"(apoptotic signaling pathway)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097194"(execution phase of apoptosis)|go:"GO:0097199"(cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|go:"GO:0097200"(cysteine-type endopeptidase activity involved in execution phase of apoptosis)|go:"GO:0097202"(activation of cysteine-type endopeptidase activity)|go:"GO:0097264"(self proteolysis)|go:"GO:0097342"(ripoptosome)|go:"GO:1901216"(positive regulation of neuron death)|interpro:IPR001309(Peptidase C14, ICE, catalytic subunit p20)|reactome:R-HSA-264870|interpro:IPR001875(Death effector)|interpro:IPR002138(Peptidase C14, caspase non-catalytic subunit p10)|interpro:IPR002398(Peptidase C14, caspase precursor p45)|interpro:IPR011029(DEATH-like)|interpro:IPR015917(Peptidase C14, caspase precursor p45, core)|interpro:IPR016129(Peptidase C14, ICE, catalytic subunit p20, active site)|interpro:IPR029030|interpro:IPR033139|interpro:IPR033170|mint:Q14790|rcsb pdb:1F9E|rcsb pdb:1I4E|rcsb pdb:1QDU|rcsb pdb:1QTN|rcsb pdb:2C2Z|rcsb pdb:2FUN|rcsb pdb:2K7Z|rcsb pdb:2Y1L|rcsb pdb:3H11|rcsb pdb:3KJN|rcsb pdb:3KJQ|rcsb pdb:4JJ7|rcsb pdb:4PRZ|rcsb pdb:4PS1|rcsb pdb:4ZBW|rcsb pdb:5H31|rcsb pdb:5H33|rcsb pdb:5JQE|rcsb pdb:5L08|rcsb pdb:6AGW|rcsb pdb:6PX9|reactome:R-HSA-111465|reactome:R-HSA-140534|reactome:R-HSA-168638|reactome:R-HSA-2562578|reactome:R-HSA-3371378|reactome:R-HSA-5213460|reactome:R-HSA-5218900|reactome:R-HSA-5357786|reactome:R-HSA-5357905|reactome:R-HSA-5660668|reactome:R-HSA-5675482|reactome:R-HSA-69416|reactome:R-HSA-75108|reactome:R-HSA-75153|reactome:R-HSA-75157|reactome:R-HSA-75158|reactome:R-HSA-9013957|reactome:R-HSA-933543|reactome:R-HSA-9686347|reactome:R-HSA-9693928|refseq:NP_001073593.1|refseq:NP_001073594.1|refseq:NP_001219.2|refseq:NP_203519.1|refseq:NP_203520.1|refseq:NP_203522.1|refseq:XP_006712852.1|refseq:XP_006712853.1|refseq:XP_006712856.1|refseq:XP_005246944.1|refseq:XP_005246945.1|refseq:XP_005246946.1|refseq:XP_005246947.1|refseq:XP_005246948.1|refseq:XP_005246949.1|refseq:XP_005246943.1|dip:DIP-30915N	-	-	-	figure legend:f6|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-uvec)|taxid:9606("Human Umbilical Vein Endothelial Cells (HUVEC)")	-	2014/01/17	2014/10/16	rogid:kpksW8E51awRfZkhWEGFlrdgnJ89606	rogid:XKI9lMiIKZTtoY2lN/QIm1yTksY9606	intact-crc:3912A3BB5517CCF8|rigid:woTWGZGD6hkh7Ira3qjVmYlNhXA	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)