#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q16665	uniprotkb:P40818	intact:EBI-447269|uniprotkb:Q53XP6|uniprotkb:Q96PT9|uniprotkb:Q9UPB1|uniprotkb:C0LZJ3|ensembl:ENSP00000338018	intact:EBI-1050865|uniprotkb:Q2TB31|uniprotkb:Q7Z3U2|uniprotkb:Q86VA0|uniprotkb:Q8IWI7|ensembl:ENSP00000302239|ensembl:ENSP00000379721|uniprotkb:B4DKA8	psi-mi:hif1a_human(display_long)|uniprotkb:ARNT-interacting protein(gene name synonym)|uniprotkb:Member of PAS protein 1(gene name synonym)|uniprotkb:Basic-helix-loop-helix-PAS protein MOP1(gene name synonym)|uniprotkb:HIF1A(gene name)|psi-mi:HIF1A(display_short)|uniprotkb:MOP1(gene name synonym)|uniprotkb:BHLHE78(gene name synonym)|uniprotkb:PASD8(gene name synonym)|uniprotkb:PAS domain-containing protein 8(gene name synonym)|uniprotkb:Class E basic helix-loop-helix protein 78(gene name synonym)	psi-mi:ubp8_human(display_long)|uniprotkb:Ubiquitin-specific-processing protease 8(gene name synonym)|uniprotkb:Deubiquitinating enzyme 8(gene name synonym)|uniprotkb:USP8(gene name)|psi-mi:USP8(display_short)|uniprotkb:KIAA0055(gene name synonym)|uniprotkb:UBPY(gene name synonym)|uniprotkb:Ubiquitin isopeptidase Y(gene name synonym)|uniprotkb:Ubiquitin thioesterase 8(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Troilo et al. (2014)	imex:IM-22097|pubmed:24378640	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-9107125|imex:IM-22097-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001230013.1|refseq:NP_001521.1|refseq:NP_851397.1|ensembl:ENST00000323441|ensembl:ENSP00000323326|ensembl:ENSP00000338018|ensembl:ENST00000539097|ensembl:ENSP00000437955|dip:DIP-29722N|ensembl:ENSG00000100644(gene)|ensembl:ENST00000337138(transcript)|go:"GO:0000302"(response to reactive oxygen species)|go:"GO:0000785"(chromatin)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001216"(DNA-binding transcription activator activity)|go:"GO:0001223"(transcription coactivator binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001525"(angiogenesis)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001678"(cellular glucose homeostasis)|go:"GO:0001755"(neural crest cell migration)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0001892"(embryonic placenta development)|go:"GO:0001922"(B-1 B cell homeostasis)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0001947"(heart looping)|go:"GO:0002039"(p53 binding)|go:"GO:0002052"(positive regulation of neuroblast proliferation)|go:"GO:0002248"(connective tissue replacement involved in inflammatory response wound healing)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0003208"(cardiac ventricle morphogenesis)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006879"(cellular iron ion homeostasis)|go:"GO:0007165"(signal transduction)|go:"GO:0007595"(lactation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008542"(visual learning)|go:"GO:0010039"(response to iron ion)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010573"(vascular endothelial growth factor production)|go:"GO:0010575"(positive regulation of vascular endothelial growth factor production)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0014850"(response to muscle activity)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0019896"(axonal transport of mitochondrion)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0021502"(neural fold elevation formation)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030502"(negative regulation of bone mineralization)|go:"GO:0030949"(positive regulation of vascular endothelial growth factor receptor signaling pathway)|go:"GO:0031514"(motile cilium)|go:"GO:0006089"(lactate metabolic process)|go:"GO:0006110"(regulation of glycolytic process)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0032364"(oxygen homeostasis)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032909"(regulation of transforming growth factor beta2 production)|go:"GO:0032963"(collagen metabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035162"(embryonic hemopoiesis)|go:"GO:0035774"(positive regulation of insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0042541"(hemoglobin biosynthetic process)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0043619"(regulation of transcription from RNA polymerase II promoter in response to oxidative stress)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045821"(positive regulation of glycolytic process)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045926"(negative regulation of growth)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046716"(muscle cell cellular homeostasis)|go:"GO:0046886"(positive regulation of hormone biosynthetic process)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048546"(digestive tract morphogenesis)|go:"GO:0051000"(positive regulation of nitric-oxide synthase activity)|go:"GO:0051216"(cartilage development)|go:"GO:0051541"(elastin metabolic process)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0060574"(intestinal epithelial cell maturation)|go:"GO:0061030"(epithelial cell differentiation involved in mammary gland alveolus development)|go:"GO:0061072"(iris morphogenesis)|go:"GO:0061298"(retina vasculature development in camera-type eye)|go:"GO:0061419"(positive regulation of transcription from RNA polymerase II promoter in response to hypoxia)|go:"GO:0070101"(positive regulation of chemokine-mediated signaling pathway)|go:"GO:0070244"(negative regulation of thymocyte apoptotic process)|go:"GO:0070888"(E-box binding)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071542"(dopaminergic neuron differentiation)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:0097411"(hypoxia-inducible factor-1alpha signaling pathway)|go:"GO:0098586"(cellular response to virus)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1903377"(negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway)|go:"GO:1903599"(positive regulation of autophagy of mitochondrion)|go:"GO:1903715"(regulation of aerobic respiration)|go:"GO:1904115"(axon cytoplasm)|go:"GO:2000273"(positive regulation of signaling receptor activity)|go:"GO:2000378"(negative regulation of reactive oxygen species metabolic process)|go:"GO:2000434"(regulation of protein neddylation)|go:"GO:2001054"(negative regulation of mesenchymal cell apoptotic process)|interpro:IPR000014(PAS)|interpro:IPR001321(Hypoxia-inducible factor-1 alpha, PAS fold)|interpro:IPR001610(PAC motif)|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR013655(PAS fold-3)|interpro:IPR013767(PAS fold)|interpro:IPR014887(HIF-1 alpha C terminal transactivation domain)|interpro:IPR021537|interpro:IPR035965|interpro:IPR036638|mint:Q16665|rcsb pdb:1D7G|rcsb pdb:1H2K|rcsb pdb:1H2L|rcsb pdb:1H2M|rcsb pdb:1L3E|rcsb pdb:1L8C|rcsb pdb:1LM8|rcsb pdb:1LQB|rcsb pdb:2ILM|rcsb pdb:3HQR|rcsb pdb:3HQU|rcsb pdb:4AJY|rcsb pdb:4H6J|rcsb pdb:5JWP|rcsb pdb:5L9B|rcsb pdb:5L9V|rcsb pdb:5LA9|rcsb pdb:5LAS|rcsb pdb:6GFX|rcsb pdb:6GMR|rcsb pdb:6YW3|reactome:R-HSA-1234158|reactome:R-HSA-1234174|reactome:R-HSA-1234176|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|reactome:R-HSA-2122947|reactome:R-HSA-400253|reactome:R-HSA-5689880|reactome:R-HSA-6785807|reactome:R-HSA-8849473|reactome:R-HSA-8857538|reactome:R-HSA-8951664	refseq:NP_001122082.1|refseq:NP_005145.3|refseq:NP_001269978.1|refseq:XP_011520495.1|ensembl:ENSG00000138592(gene)|ensembl:ENST00000307179(transcript)|ensembl:ENST00000396444(transcript)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0007032"(endosome organization)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0030496"(midbody)|go:"GO:0031313"(extrinsic component of endosome membrane)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0043197"(dendritic spine)|go:"GO:0045296"(cadherin binding)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0071108"(protein K48-linked deubiquitination)|go:"GO:0071549"(cellular response to dexamethasone stimulus)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099576"(regulation of protein catabolic process at postsynapse, modulating synaptic transmission)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR001763(Rhodanese-like)|interpro:IPR015063(Region of unknown function DUF1873)|interpro:IPR018200|interpro:IPR028889|interpro:IPR036873|interpro:IPR038765|mint:P40818|rcsb pdb:1WHB|rcsb pdb:2A9U|rcsb pdb:2GFO|rcsb pdb:2GWF|rcsb pdb:3N3K|rcsb pdb:6F09|reactome:R-HSA-1358803|reactome:R-HSA-4641263|reactome:R-HSA-5689880|reactome:R-HSA-6807004|refseq:XP_006720824.1|dip:DIP-40365N	-	-	-	figure legend:f2f|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2014/01/31	2014/10/16	rogid:3XRt8HFMCRlxcYR2KfuFSq6gVBg9606	rogid:hpBBzyA4lc9is80ZFJBr1fyEyOM9606	intact-crc:172F5AEBEA2F46D3|rigid:QCb7iKqV/vXZ6f7Idx2+ay0f/hI	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P40818	uniprotkb:Q99814	intact:EBI-1050865|uniprotkb:Q2TB31|uniprotkb:Q7Z3U2|uniprotkb:Q86VA0|uniprotkb:Q8IWI7|ensembl:ENSP00000302239|ensembl:ENSP00000379721|uniprotkb:B4DKA8	intact:EBI-447470|uniprotkb:Q86VA2|uniprotkb:Q99630|ensembl:ENSP00000263734	psi-mi:ubp8_human(display_long)|uniprotkb:Ubiquitin-specific-processing protease 8(gene name synonym)|uniprotkb:Deubiquitinating enzyme 8(gene name synonym)|uniprotkb:USP8(gene name)|psi-mi:USP8(display_short)|uniprotkb:KIAA0055(gene name synonym)|uniprotkb:UBPY(gene name synonym)|uniprotkb:Ubiquitin isopeptidase Y(gene name synonym)|uniprotkb:Ubiquitin thioesterase 8(gene name synonym)	psi-mi:epas1_human(display_long)|uniprotkb:EPAS1(gene name)|psi-mi:EPAS1(display_short)|uniprotkb:HIF2A(gene name synonym)|uniprotkb:MOP2(gene name synonym)|uniprotkb:Member of PAS protein 2(gene name synonym)|uniprotkb:Basic-helix-loop-helix-PAS protein MOP2(gene name synonym)|uniprotkb:BHLHE73(gene name synonym)|uniprotkb:PASD2(gene name synonym)|uniprotkb:Hypoxia-inducible factor 2-alpha(gene name synonym)|uniprotkb:HIF-1-alpha-like factor(gene name synonym)|uniprotkb:PAS domain-containing protein 2(gene name synonym)|uniprotkb:Class E basic helix-loop-helix protein 73(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Troilo et al. (2014)	imex:IM-22097|pubmed:24378640	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-9107145|imex:IM-22097-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001122082.1|refseq:NP_005145.3|refseq:NP_001269978.1|refseq:XP_011520495.1|ensembl:ENSG00000138592(gene)|ensembl:ENST00000307179(transcript)|ensembl:ENST00000396444(transcript)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0007032"(endosome organization)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0030496"(midbody)|go:"GO:0031313"(extrinsic component of endosome membrane)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0043197"(dendritic spine)|go:"GO:0045296"(cadherin binding)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0071108"(protein K48-linked deubiquitination)|go:"GO:0071549"(cellular response to dexamethasone stimulus)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099576"(regulation of protein catabolic process at postsynapse, modulating synaptic transmission)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR001763(Rhodanese-like)|interpro:IPR015063(Region of unknown function DUF1873)|interpro:IPR018200|interpro:IPR028889|interpro:IPR036873|interpro:IPR038765|mint:P40818|rcsb pdb:1WHB|rcsb pdb:2A9U|rcsb pdb:2GFO|rcsb pdb:2GWF|rcsb pdb:3N3K|rcsb pdb:6F09|reactome:R-HSA-1358803|reactome:R-HSA-4641263|reactome:R-HSA-5689880|reactome:R-HSA-6807004|refseq:XP_006720824.1|dip:DIP-40365N	refseq:NP_001421.2|dip:DIP-32857N|go:"GO:0048625"(myoblast fate commitment)|go:"GO:0055072"(iron ion homeostasis)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:2000434"(regulation of protein neddylation)|interpro:IPR000014(PAS)|interpro:IPR001067(Nuclear translocator)|interpro:IPR001610(PAC motif)|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR013655(PAS fold-3)|interpro:IPR013767(PAS fold)|interpro:IPR014887(HIF-1 alpha C terminal transactivation domain)|interpro:IPR021537|interpro:IPR035965|interpro:IPR036638|mint:Q99814|rcsb pdb:1P97|rcsb pdb:2A24|rcsb pdb:3F1N|rcsb pdb:3F1O|rcsb pdb:3F1P|rcsb pdb:3H7W|rcsb pdb:3H82|rcsb pdb:4GHI|rcsb pdb:4GS9|rcsb pdb:4PKY|rcsb pdb:4XT2|rcsb pdb:5KIZ|rcsb pdb:5TBM|rcsb pdb:5UFP|rcsb pdb:6BVB|rcsb pdb:6CZW|rcsb pdb:6D09|rcsb pdb:6D0B|rcsb pdb:6D0C|rcsb pdb:6I7Q|rcsb pdb:6I7R|rcsb pdb:6X21|rcsb pdb:6X28|rcsb pdb:6X2H|rcsb pdb:6X37|rcsb pdb:6X3D|reactome:R-HSA-1234158|reactome:R-HSA-1234174|go:"GO:0048469"(cell maturation)|reactome:R-HSA-1234176|reactome:R-HSA-452723|reactome:R-HSA-8849473|reactome:R-HSA-8951664|reactome:R-HSA-9664873|ensembl:ENSG00000116016(gene)|ensembl:ENST00000263734(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001223"(transcription coactivator binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001525"(angiogenesis)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001892"(embryonic placenta development)|go:"GO:0001974"(blood vessel remodeling)|go:"GO:0002027"(regulation of heart rate)|go:"GO:0003677"(DNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007165"(signal transduction)|go:"GO:0007601"(visual perception)|go:"GO:0008134"(transcription factor binding)|go:"GO:0016607"(nuclear speck)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0030324"(lung development)|go:"GO:0042415"(norepinephrine metabolic process)|go:"GO:0043129"(surfactant homeostasis)|go:"GO:0043619"(regulation of transcription from RNA polymerase II promoter in response to oxidative stress)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046982"(protein heterodimerization activity)	-	-	-	figure legend:sf3c|comment:"Moreover, a stable proline‐mutant derivative of HIF2α, HIF2α(P405A/P531A), coimmunoprecipitates with USP8 (supplementary Fig S3C)"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2014/01/31	2014/10/16	rogid:hpBBzyA4lc9is80ZFJBr1fyEyOM9606	rogid:rBmVytqL/OrXjDJxbgvsa8r98DI9606	intact-crc:6C421FF9D3E3834F|rigid:Yp0aSSR3yBhFoUdHxdzOQ5mUkQ4	false	-	ha tag:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q99814	uniprotkb:P40818	intact:EBI-447470|uniprotkb:Q86VA2|uniprotkb:Q99630|ensembl:ENSP00000263734	intact:EBI-1050865|uniprotkb:Q2TB31|uniprotkb:Q7Z3U2|uniprotkb:Q86VA0|uniprotkb:Q8IWI7|ensembl:ENSP00000302239|ensembl:ENSP00000379721|uniprotkb:B4DKA8	psi-mi:epas1_human(display_long)|uniprotkb:EPAS1(gene name)|psi-mi:EPAS1(display_short)|uniprotkb:HIF2A(gene name synonym)|uniprotkb:MOP2(gene name synonym)|uniprotkb:Member of PAS protein 2(gene name synonym)|uniprotkb:Basic-helix-loop-helix-PAS protein MOP2(gene name synonym)|uniprotkb:BHLHE73(gene name synonym)|uniprotkb:PASD2(gene name synonym)|uniprotkb:Hypoxia-inducible factor 2-alpha(gene name synonym)|uniprotkb:HIF-1-alpha-like factor(gene name synonym)|uniprotkb:PAS domain-containing protein 2(gene name synonym)|uniprotkb:Class E basic helix-loop-helix protein 73(gene name synonym)	psi-mi:ubp8_human(display_long)|uniprotkb:Ubiquitin-specific-processing protease 8(gene name synonym)|uniprotkb:Deubiquitinating enzyme 8(gene name synonym)|uniprotkb:USP8(gene name)|psi-mi:USP8(display_short)|uniprotkb:KIAA0055(gene name synonym)|uniprotkb:UBPY(gene name synonym)|uniprotkb:Ubiquitin isopeptidase Y(gene name synonym)|uniprotkb:Ubiquitin thioesterase 8(gene name synonym)	psi-mi:"MI:0096"(pull down)	Troilo et al. (2014)	imex:IM-22097|pubmed:24378640	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-9107137|imex:IM-22097-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001421.2|dip:DIP-32857N|go:"GO:0048625"(myoblast fate commitment)|go:"GO:0055072"(iron ion homeostasis)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:2000434"(regulation of protein neddylation)|interpro:IPR000014(PAS)|interpro:IPR001067(Nuclear translocator)|interpro:IPR001610(PAC motif)|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR013655(PAS fold-3)|interpro:IPR013767(PAS fold)|interpro:IPR014887(HIF-1 alpha C terminal transactivation domain)|interpro:IPR021537|interpro:IPR035965|interpro:IPR036638|mint:Q99814|rcsb pdb:1P97|rcsb pdb:2A24|rcsb pdb:3F1N|rcsb pdb:3F1O|rcsb pdb:3F1P|rcsb pdb:3H7W|rcsb pdb:3H82|rcsb pdb:4GHI|rcsb pdb:4GS9|rcsb pdb:4PKY|rcsb pdb:4XT2|rcsb pdb:5KIZ|rcsb pdb:5TBM|rcsb pdb:5UFP|rcsb pdb:6BVB|rcsb pdb:6CZW|rcsb pdb:6D09|rcsb pdb:6D0B|rcsb pdb:6D0C|rcsb pdb:6I7Q|rcsb pdb:6I7R|rcsb pdb:6X21|rcsb pdb:6X28|rcsb pdb:6X2H|rcsb pdb:6X37|rcsb pdb:6X3D|reactome:R-HSA-1234158|reactome:R-HSA-1234174|go:"GO:0048469"(cell maturation)|reactome:R-HSA-1234176|reactome:R-HSA-452723|reactome:R-HSA-8849473|reactome:R-HSA-8951664|reactome:R-HSA-9664873|ensembl:ENSG00000116016(gene)|ensembl:ENST00000263734(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001223"(transcription coactivator binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001525"(angiogenesis)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001892"(embryonic placenta development)|go:"GO:0001974"(blood vessel remodeling)|go:"GO:0002027"(regulation of heart rate)|go:"GO:0003677"(DNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007165"(signal transduction)|go:"GO:0007601"(visual perception)|go:"GO:0008134"(transcription factor binding)|go:"GO:0016607"(nuclear speck)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0030324"(lung development)|go:"GO:0042415"(norepinephrine metabolic process)|go:"GO:0043129"(surfactant homeostasis)|go:"GO:0043619"(regulation of transcription from RNA polymerase II promoter in response to oxidative stress)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046982"(protein heterodimerization activity)	refseq:NP_001122082.1|refseq:NP_005145.3|refseq:NP_001269978.1|refseq:XP_011520495.1|ensembl:ENSG00000138592(gene)|ensembl:ENST00000307179(transcript)|ensembl:ENST00000396444(transcript)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0007032"(endosome organization)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0030496"(midbody)|go:"GO:0031313"(extrinsic component of endosome membrane)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0043197"(dendritic spine)|go:"GO:0045296"(cadherin binding)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0071108"(protein K48-linked deubiquitination)|go:"GO:0071549"(cellular response to dexamethasone stimulus)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099576"(regulation of protein catabolic process at postsynapse, modulating synaptic transmission)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR001763(Rhodanese-like)|interpro:IPR015063(Region of unknown function DUF1873)|interpro:IPR018200|interpro:IPR028889|interpro:IPR036873|interpro:IPR038765|mint:P40818|rcsb pdb:1WHB|rcsb pdb:2A9U|rcsb pdb:2GFO|rcsb pdb:2GWF|rcsb pdb:3N3K|rcsb pdb:6F09|reactome:R-HSA-1358803|reactome:R-HSA-4641263|reactome:R-HSA-5689880|reactome:R-HSA-6807004|refseq:XP_006720824.1|dip:DIP-40365N	-	-	-	figure legend:s3b|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/01/31	2014/10/16	rogid:rBmVytqL/OrXjDJxbgvsa8r98DI9606	rogid:hpBBzyA4lc9is80ZFJBr1fyEyOM9606	intact-crc:856A10CD3F1AE22D|rigid:Yp0aSSR3yBhFoUdHxdzOQ5mUkQ4	false	-	glutathione s tranferase tag:?-?	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:P40818	uniprotkb:Q16665	intact:EBI-1050865|uniprotkb:Q2TB31|uniprotkb:Q7Z3U2|uniprotkb:Q86VA0|uniprotkb:Q8IWI7|ensembl:ENSP00000302239|ensembl:ENSP00000379721|uniprotkb:B4DKA8	intact:EBI-447269|uniprotkb:Q53XP6|uniprotkb:Q96PT9|uniprotkb:Q9UPB1|uniprotkb:C0LZJ3|ensembl:ENSP00000338018	psi-mi:ubp8_human(display_long)|uniprotkb:Ubiquitin-specific-processing protease 8(gene name synonym)|uniprotkb:Deubiquitinating enzyme 8(gene name synonym)|uniprotkb:USP8(gene name)|psi-mi:USP8(display_short)|uniprotkb:KIAA0055(gene name synonym)|uniprotkb:UBPY(gene name synonym)|uniprotkb:Ubiquitin isopeptidase Y(gene name synonym)|uniprotkb:Ubiquitin thioesterase 8(gene name synonym)	psi-mi:hif1a_human(display_long)|uniprotkb:ARNT-interacting protein(gene name synonym)|uniprotkb:Member of PAS protein 1(gene name synonym)|uniprotkb:Basic-helix-loop-helix-PAS protein MOP1(gene name synonym)|uniprotkb:HIF1A(gene name)|psi-mi:HIF1A(display_short)|uniprotkb:MOP1(gene name synonym)|uniprotkb:BHLHE78(gene name synonym)|uniprotkb:PASD8(gene name synonym)|uniprotkb:PAS domain-containing protein 8(gene name synonym)|uniprotkb:Class E basic helix-loop-helix protein 78(gene name synonym)	psi-mi:"MI:0096"(pull down)	Troilo et al. (2014)	imex:IM-22097|pubmed:24378640	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-9107129|imex:IM-22097-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001122082.1|refseq:NP_005145.3|refseq:NP_001269978.1|refseq:XP_011520495.1|ensembl:ENSG00000138592(gene)|ensembl:ENST00000307179(transcript)|ensembl:ENST00000396444(transcript)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0007032"(endosome organization)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0030496"(midbody)|go:"GO:0031313"(extrinsic component of endosome membrane)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0043197"(dendritic spine)|go:"GO:0045296"(cadherin binding)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0071108"(protein K48-linked deubiquitination)|go:"GO:0071549"(cellular response to dexamethasone stimulus)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099576"(regulation of protein catabolic process at postsynapse, modulating synaptic transmission)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR001763(Rhodanese-like)|interpro:IPR015063(Region of unknown function DUF1873)|interpro:IPR018200|interpro:IPR028889|interpro:IPR036873|interpro:IPR038765|mint:P40818|rcsb pdb:1WHB|rcsb pdb:2A9U|rcsb pdb:2GFO|rcsb pdb:2GWF|rcsb pdb:3N3K|rcsb pdb:6F09|reactome:R-HSA-1358803|reactome:R-HSA-4641263|reactome:R-HSA-5689880|reactome:R-HSA-6807004|refseq:XP_006720824.1|dip:DIP-40365N	refseq:NP_001230013.1|refseq:NP_001521.1|refseq:NP_851397.1|ensembl:ENST00000323441|ensembl:ENSP00000323326|ensembl:ENSP00000338018|ensembl:ENST00000539097|ensembl:ENSP00000437955|dip:DIP-29722N|ensembl:ENSG00000100644(gene)|ensembl:ENST00000337138(transcript)|go:"GO:0000302"(response to reactive oxygen species)|go:"GO:0000785"(chromatin)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001216"(DNA-binding transcription activator activity)|go:"GO:0001223"(transcription coactivator binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001525"(angiogenesis)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001678"(cellular glucose homeostasis)|go:"GO:0001755"(neural crest cell migration)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0001892"(embryonic placenta development)|go:"GO:0001922"(B-1 B cell homeostasis)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0001947"(heart looping)|go:"GO:0002039"(p53 binding)|go:"GO:0002052"(positive regulation of neuroblast proliferation)|go:"GO:0002248"(connective tissue replacement involved in inflammatory response wound healing)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0003208"(cardiac ventricle morphogenesis)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006879"(cellular iron ion homeostasis)|go:"GO:0007165"(signal transduction)|go:"GO:0007595"(lactation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008542"(visual learning)|go:"GO:0010039"(response to iron ion)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010573"(vascular endothelial growth factor production)|go:"GO:0010575"(positive regulation of vascular endothelial growth factor production)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0014850"(response to muscle activity)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0019896"(axonal transport of mitochondrion)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0021502"(neural fold elevation formation)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030502"(negative regulation of bone mineralization)|go:"GO:0030949"(positive regulation of vascular endothelial growth factor receptor signaling pathway)|go:"GO:0031514"(motile cilium)|go:"GO:0006089"(lactate metabolic process)|go:"GO:0006110"(regulation of glycolytic process)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0032364"(oxygen homeostasis)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032909"(regulation of transforming growth factor beta2 production)|go:"GO:0032963"(collagen metabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035162"(embryonic hemopoiesis)|go:"GO:0035774"(positive regulation of insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0042541"(hemoglobin biosynthetic process)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0043619"(regulation of transcription from RNA polymerase II promoter in response to oxidative stress)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045821"(positive regulation of glycolytic process)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045926"(negative regulation of growth)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046716"(muscle cell cellular homeostasis)|go:"GO:0046886"(positive regulation of hormone biosynthetic process)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048546"(digestive tract morphogenesis)|go:"GO:0051000"(positive regulation of nitric-oxide synthase activity)|go:"GO:0051216"(cartilage development)|go:"GO:0051541"(elastin metabolic process)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0060574"(intestinal epithelial cell maturation)|go:"GO:0061030"(epithelial cell differentiation involved in mammary gland alveolus development)|go:"GO:0061072"(iris morphogenesis)|go:"GO:0061298"(retina vasculature development in camera-type eye)|go:"GO:0061419"(positive regulation of transcription from RNA polymerase II promoter in response to hypoxia)|go:"GO:0070101"(positive regulation of chemokine-mediated signaling pathway)|go:"GO:0070244"(negative regulation of thymocyte apoptotic process)|go:"GO:0070888"(E-box binding)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071542"(dopaminergic neuron differentiation)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:0097411"(hypoxia-inducible factor-1alpha signaling pathway)|go:"GO:0098586"(cellular response to virus)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1903377"(negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway)|go:"GO:1903599"(positive regulation of autophagy of mitochondrion)|go:"GO:1903715"(regulation of aerobic respiration)|go:"GO:1904115"(axon cytoplasm)|go:"GO:2000273"(positive regulation of signaling receptor activity)|go:"GO:2000378"(negative regulation of reactive oxygen species metabolic process)|go:"GO:2000434"(regulation of protein neddylation)|go:"GO:2001054"(negative regulation of mesenchymal cell apoptotic process)|interpro:IPR000014(PAS)|interpro:IPR001321(Hypoxia-inducible factor-1 alpha, PAS fold)|interpro:IPR001610(PAC motif)|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR013655(PAS fold-3)|interpro:IPR013767(PAS fold)|interpro:IPR014887(HIF-1 alpha C terminal transactivation domain)|interpro:IPR021537|interpro:IPR035965|interpro:IPR036638|mint:Q16665|rcsb pdb:1D7G|rcsb pdb:1H2K|rcsb pdb:1H2L|rcsb pdb:1H2M|rcsb pdb:1L3E|rcsb pdb:1L8C|rcsb pdb:1LM8|rcsb pdb:1LQB|rcsb pdb:2ILM|rcsb pdb:3HQR|rcsb pdb:3HQU|rcsb pdb:4AJY|rcsb pdb:4H6J|rcsb pdb:5JWP|rcsb pdb:5L9B|rcsb pdb:5L9V|rcsb pdb:5LA9|rcsb pdb:5LAS|rcsb pdb:6GFX|rcsb pdb:6GMR|rcsb pdb:6YW3|reactome:R-HSA-1234158|reactome:R-HSA-1234174|reactome:R-HSA-1234176|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|reactome:R-HSA-2122947|reactome:R-HSA-400253|reactome:R-HSA-5689880|reactome:R-HSA-6785807|reactome:R-HSA-8849473|reactome:R-HSA-8857538|reactome:R-HSA-8951664	-	-	-	figure legend:f2g sf3a|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/01/31	2014/10/16	rogid:hpBBzyA4lc9is80ZFJBr1fyEyOM9606	rogid:3XRt8HFMCRlxcYR2KfuFSq6gVBg9606	intact-crc:11CE1AEEBFD92D61|rigid:QCb7iKqV/vXZ6f7Idx2+ay0f/hI	false	glutathione s tranferase tag:?-?	sufficient binding region:85-345	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)