#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q63503	uniprotkb:P02651	intact:EBI-9845033|uniprotkb:Q6P6S7	intact:EBI-9845015|uniprotkb:Q5BK92	psi-mi:nr1d1_rat(display_long)|uniprotkb:Nr1d1(gene name)|psi-mi:Nr1d1(display_short)|uniprotkb:Rev-erbA-alpha(gene name synonym)|uniprotkb:V-erbA-related protein 1(gene name synonym)	psi-mi:apoa4_rat(display_long)|uniprotkb:Apoa4(gene name)|psi-mi:Apoa4(display_short)|uniprotkb:Apolipoprotein A4(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Li et al. (2014)	pubmed:24311788|imex:IM-23199	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9845012|imex:IM-23199-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	reactome:R-RNO-383280|rgd:628827|refseq:NP_001106893.1|refseq:NP_665718.2|interpro:IPR000536(Nuclear hormone receptor, ligand-binding, core)|interpro:IPR001723(Steroid hormone receptor)|interpro:IPR001628(Zinc finger, nuclear hormone receptor-type)|interpro:IPR013088(Zinc finger, NHR/GATA-type)|interpro:IPR035500|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001678"(cellular glucose homeostasis)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0004879"(nuclear receptor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005978"(glycogen biosynthetic process)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009648"(photoperiodism)|go:"GO:0009755"(hormone-mediated signaling pathway)|go:"GO:0010498"(proteasomal protein catabolic process)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0020037"(heme binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030425"(dendrite)|go:"GO:0031648"(protein destabilization)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0034144"(negative regulation of toll-like receptor 4 signaling pathway)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0042749"(regulation of circadian sleep/wake cycle)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042753"(positive regulation of circadian rhythm)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043197"(dendritic spine)|go:"GO:0044321"(response to leptin)|go:"GO:0045598"(regulation of fat cell differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0060086"(circadian temperature homeostasis)|go:"GO:0061178"(regulation of insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0061469"(regulation of type B pancreatic cell proliferation)|go:"GO:0061889"(negative regulation of astrocyte activation)|go:"GO:0070859"(positive regulation of bile acid biosynthetic process)|go:"GO:0070888"(E-box binding)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|go:"GO:0150079"(negative regulation of neuroinflammatory response)|go:"GO:1903979"(negative regulation of microglial cell activation)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000489"(regulation of hepatic stellate cell activation)	refseq:NP_036869.1|interpro:IPR000074(Apolipoprotein A1/A4/E)|rgd:2132|go:"GO:0002227"(innate immune response in mucosa)|go:"GO:0005507"(copper ion binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005615"(extracellular space)|go:"GO:0006695"(cholesterol biosynthetic process)|go:"GO:0006869"(lipid transport)|go:"GO:0006982"(response to lipid hydroperoxide)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0008203"(cholesterol metabolic process)|go:"GO:0008289"(lipid binding)|go:"GO:0010873"(positive regulation of cholesterol esterification)|go:"GO:0010898"(positive regulation of triglyceride catabolic process)|go:"GO:0014012"(peripheral nervous system axon regeneration)|go:"GO:0015485"(cholesterol binding)|go:"GO:0016042"(lipid catabolic process)|go:"GO:0016209"(antioxidant activity)|go:"GO:0019430"(removal of superoxide radicals)|go:"GO:0030300"(regulation of intestinal cholesterol absorption)|go:"GO:0031210"(phosphatidylcholine binding)|go:"GO:0032094"(response to food)|go:"GO:0032374"(regulation of cholesterol transport)|go:"GO:0033344"(cholesterol efflux)|go:"GO:0033700"(phospholipid efflux)|go:"GO:0034014"(response to triglyceride)|go:"GO:0034361"(very-low-density lipoprotein particle)|go:"GO:0034364"(high-density lipoprotein particle)|go:"GO:0034372"(very-low-density lipoprotein particle remodeling)|go:"GO:0034380"(high-density lipoprotein particle assembly)|go:"GO:0034445"(negative regulation of plasma lipoprotein oxidation)|go:"GO:0035634"(response to stilbenoid)|go:"GO:0042157"(lipoprotein metabolic process)|go:"GO:0042627"(chylomicron)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0042744"(hydrogen peroxide catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043691"(reverse cholesterol transport)|go:"GO:0045202"(synapse)|go:"GO:0045723"(positive regulation of fatty acid biosynthetic process)|go:"GO:0046470"(phosphatidylcholine metabolic process)|go:"GO:0046889"(positive regulation of lipid biosynthetic process)|go:"GO:0051006"(positive regulation of lipoprotein lipase activity)|go:"GO:0055088"(lipid homeostasis)|go:"GO:0060228"(phosphatidylcholine-sterol O-acyltransferase activator activity)|go:"GO:0065005"(protein-lipid complex assembly)|go:"GO:0070328"(triglyceride homeostasis)|go:"GO:0120020"(cholesterol transfer activity)	-	-	-	figure legend:No figure|dataset:Cardiac - Interactions involving cardiac related proteins|dataset:Diabetes - Interactions investigated in the context of Diabetes|dataset:Affinomics - Interactions curated for the Affinomics consortium.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	-	2014/10/13	2014/10/16	rogid:Mz6cSE7oI1IdLir42TL+9AERq4E10116	rogid:0grewnmOmUt11Y1Pbczqd/pEGBM10116	intact-crc:2C168E8116712809|rigid:NLns3IZjhF/FeAph5F/YWU7MB3A	false	sufficient binding region:?-?	sufficient binding region:30-391	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P06727	uniprotkb:P20393	intact:EBI-1222447|uniprotkb:Q14CW8|uniprotkb:Q6Q787|uniprotkb:A8MSL6|ensembl:ENSP00000350425	intact:EBI-2811738|uniprotkb:Q15304|uniprotkb:Q0P5Z4|ensembl:ENSP00000246672	psi-mi:apoa4_human(display_long)|uniprotkb:APOA4(gene name)|psi-mi:APOA4(display_short)|uniprotkb:Apolipoprotein A4(gene name synonym)	psi-mi:nr1d1_human(display_long)|uniprotkb:NR1D1(gene name)|psi-mi:NR1D1(display_short)|uniprotkb:EAR1(gene name synonym)|uniprotkb:HREV(gene name synonym)|uniprotkb:THRAL(gene name synonym)|uniprotkb:Rev-erbA-alpha(gene name synonym)|uniprotkb:V-erbA-related protein 1(gene name synonym)	psi-mi:"MI:0813"(proximity ligation assay)	Li et al. (2014)	pubmed:24311788|imex:IM-23199	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9845525|imex:IM-23199-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000473.2|dip:DIP-38333N|ensembl:ENSG00000110244(gene)|ensembl:ENST00000357780(transcript)|go:"GO:0002227"(innate immune response in mucosa)|go:"GO:0005319"(lipid transporter activity)|go:"GO:0005507"(copper ion binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005769"(early endosome)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005829"(cytosol)|go:"GO:0006695"(cholesterol biosynthetic process)|go:"GO:0006869"(lipid transport)|go:"GO:0006982"(response to lipid hydroperoxide)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0008203"(cholesterol metabolic process)|go:"GO:0008289"(lipid binding)|go:"GO:0010873"(positive regulation of cholesterol esterification)|go:"GO:0010898"(positive regulation of triglyceride catabolic process)|go:"GO:0015485"(cholesterol binding)|go:"GO:0016042"(lipid catabolic process)|go:"GO:0016209"(antioxidant activity)|go:"GO:0019430"(removal of superoxide radicals)|go:"GO:0030300"(regulation of intestinal cholesterol absorption)|go:"GO:0031210"(phosphatidylcholine binding)|go:"GO:0032374"(regulation of cholesterol transport)|go:"GO:0033344"(cholesterol efflux)|go:"GO:0033700"(phospholipid efflux)|go:"GO:0034361"(very-low-density lipoprotein particle)|go:"GO:0034364"(high-density lipoprotein particle)|go:"GO:0034371"(chylomicron remodeling)|go:"GO:0034372"(very-low-density lipoprotein particle remodeling)|go:"GO:0034375"(high-density lipoprotein particle remodeling)|go:"GO:0034378"(chylomicron assembly)|go:"GO:0034380"(high-density lipoprotein particle assembly)|go:"GO:0034445"(negative regulation of plasma lipoprotein oxidation)|go:"GO:0035634"(response to stilbenoid)|go:"GO:0042157"(lipoprotein metabolic process)|go:"GO:0042627"(chylomicron)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0042744"(hydrogen peroxide catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043691"(reverse cholesterol transport)|go:"GO:0045723"(positive regulation of fatty acid biosynthetic process)|go:"GO:0046470"(phosphatidylcholine metabolic process)|go:"GO:0046889"(positive regulation of lipid biosynthetic process)|go:"GO:0051006"(positive regulation of lipoprotein lipase activity)|go:"GO:0055088"(lipid homeostasis)|go:"GO:0060228"(phosphatidylcholine-sterol O-acyltransferase activator activity)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0065005"(protein-lipid complex assembly)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|go:"GO:0120020"(cholesterol transfer activity)|interpro:IPR000074(Apolipoprotein A1/A4/E)|rcsb pdb:3S84|reactome:R-HSA-8963888|reactome:R-HSA-8963889|reactome:R-HSA-8963901|reactome:R-HSA-975634|reactome:R-HSA-977225|go:"GO:0070328"(triglyceride homeostasis)	refseq:NP_068370.1|ensembl:ENSG00000126368(gene)|ensembl:ENST00000246672(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001678"(cellular glucose homeostasis)|go:"GO:0003707"(steroid hormone receptor activity)|go:"GO:0004879"(nuclear receptor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005978"(glycogen biosynthetic process)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010498"(proteasomal protein catabolic process)|go:"GO:0016604"(nuclear body)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0020037"(heme binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030425"(dendrite)|go:"GO:0031648"(protein destabilization)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0009755"(hormone-mediated signaling pathway)|go:"GO:0034144"(negative regulation of toll-like receptor 4 signaling pathway)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0042749"(regulation of circadian sleep/wake cycle)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043197"(dendritic spine)|go:"GO:0044321"(response to leptin)|go:"GO:0045598"(regulation of fat cell differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0060086"(circadian temperature homeostasis)|go:"GO:0061178"(regulation of insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0061469"(regulation of type B pancreatic cell proliferation)|go:"GO:0061889"(negative regulation of astrocyte activation)|go:"GO:0070859"(positive regulation of bile acid biosynthetic process)|go:"GO:0070888"(E-box binding)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|go:"GO:0150079"(negative regulation of neuroinflammatory response)|go:"GO:1903979"(negative regulation of microglial cell activation)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000536(Nuclear hormone receptor, ligand-binding, core)|interpro:IPR001628(Zinc finger, nuclear hormone receptor-type)|interpro:IPR001723(Steroid hormone receptor)|interpro:IPR013088(Zinc finger, NHR/GATA-type)|interpro:IPR035500|rcsb pdb:1A6Y|rcsb pdb:1EF6|rcsb pdb:1GA5|rcsb pdb:1HLZ|rcsb pdb:3N00|reactome:R-HSA-1368071|reactome:R-HSA-1989781|reactome:R-HSA-2151201|reactome:R-HSA-383280|reactome:R-HSA-400253|reactome:R-HSA-9707616|dip:DIP-48396N	go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)	-	-	figure legend:4B|dataset:Cardiac - Interactions involving cardiac related proteins|dataset:Diabetes - Interactions investigated in the context of Diabetes|dataset:Affinomics - Interactions curated for the Affinomics consortium.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hep_g2)|taxid:9606("Homo sapiens hepatocellular carcinoma (HCC) cells (p53-wt).")	-	2014/10/13	2020/06/18	rogid:95b7Xlqg/plh9/R7xhLBsMXQscM9606	rogid:UfaVQzUQ3wD4xDBh1sjp+eaawY89606	intact-crc:0FADB274E5F6E44E|rigid:uPYT74LtVJvlroLLex8NvjpH5zM	false	his tag:n-n|green fluorescent protein tag:?-?	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:P06727	ensembl:ENSG00000131482	intact:EBI-1222447|uniprotkb:Q14CW8|uniprotkb:Q6Q787|uniprotkb:A8MSL6|ensembl:ENSP00000350425	intact:EBI-3989621	psi-mi:apoa4_human(display_long)|uniprotkb:APOA4(gene name)|psi-mi:APOA4(display_short)|uniprotkb:Apolipoprotein A4(gene name synonym)	psi-mi:g6pc_human_gene(display_short)|psi-mi:ENSG00000131482(display_long)	psi-mi:"MI:0402"(chromatin immunoprecipitation assay)	Li et al. (2014)	pubmed:24311788|imex:IM-23199	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9845646|imex:IM-23199-6	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0250"(gene)	refseq:NP_000473.2|dip:DIP-38333N|ensembl:ENSG00000110244(gene)|ensembl:ENST00000357780(transcript)|go:"GO:0002227"(innate immune response in mucosa)|go:"GO:0005319"(lipid transporter activity)|go:"GO:0005507"(copper ion binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005769"(early endosome)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005829"(cytosol)|go:"GO:0006695"(cholesterol biosynthetic process)|go:"GO:0006869"(lipid transport)|go:"GO:0006982"(response to lipid hydroperoxide)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0008203"(cholesterol metabolic process)|go:"GO:0008289"(lipid binding)|go:"GO:0010873"(positive regulation of cholesterol esterification)|go:"GO:0010898"(positive regulation of triglyceride catabolic process)|go:"GO:0015485"(cholesterol binding)|go:"GO:0016042"(lipid catabolic process)|go:"GO:0016209"(antioxidant activity)|go:"GO:0019430"(removal of superoxide radicals)|go:"GO:0030300"(regulation of intestinal cholesterol absorption)|go:"GO:0031210"(phosphatidylcholine binding)|go:"GO:0032374"(regulation of cholesterol transport)|go:"GO:0033344"(cholesterol efflux)|go:"GO:0033700"(phospholipid efflux)|go:"GO:0034361"(very-low-density lipoprotein particle)|go:"GO:0034364"(high-density lipoprotein particle)|go:"GO:0034371"(chylomicron remodeling)|go:"GO:0034372"(very-low-density lipoprotein particle remodeling)|go:"GO:0034375"(high-density lipoprotein particle remodeling)|go:"GO:0034378"(chylomicron assembly)|go:"GO:0034380"(high-density lipoprotein particle assembly)|go:"GO:0034445"(negative regulation of plasma lipoprotein oxidation)|go:"GO:0035634"(response to stilbenoid)|go:"GO:0042157"(lipoprotein metabolic process)|go:"GO:0042627"(chylomicron)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0042744"(hydrogen peroxide catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043691"(reverse cholesterol transport)|go:"GO:0045723"(positive regulation of fatty acid biosynthetic process)|go:"GO:0046470"(phosphatidylcholine metabolic process)|go:"GO:0046889"(positive regulation of lipid biosynthetic process)|go:"GO:0051006"(positive regulation of lipoprotein lipase activity)|go:"GO:0055088"(lipid homeostasis)|go:"GO:0060228"(phosphatidylcholine-sterol O-acyltransferase activator activity)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0065005"(protein-lipid complex assembly)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|go:"GO:0120020"(cholesterol transfer activity)|interpro:IPR000074(Apolipoprotein A1/A4/E)|rcsb pdb:3S84|reactome:R-HSA-8963888|reactome:R-HSA-8963889|reactome:R-HSA-8963901|reactome:R-HSA-975634|reactome:R-HSA-977225|go:"GO:0070328"(triglyceride homeostasis)	-	go:"GO:0005634"(nucleus)	-	-	figure legend:5A|causality statement:P06727 decreases expression at RNA level of  ENSG00000131482.|causality statement:P06727 decreases expression at RNA level of  ENSG00000100889.|causality statement:P06727 and P20393 decreases expression at RNA level of  ENSG00000131482.|causality statement:P06727  increases expression at RNA level of  ENSG00000126368.|causality statement:P06727  increases expression at protein level of ENSG00000126368.|dataset:Cardiac - Interactions involving cardiac related proteins|dataset:Diabetes - Interactions investigated in the context of Diabetes|dataset:Affinomics - Interactions curated for the Affinomics consortium.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hep_g2)|taxid:9606("Homo sapiens hepatocellular carcinoma (HCC) cells (p53-wt).")	-	2014/10/13	2020/06/18	rogid:95b7Xlqg/plh9/R7xhLBsMXQscM9606	-	intact-crc:7E8C4108B9FC55E5	false	green fluorescent protein tag:?-?|his tag:n-n	sufficient binding region:?-?	-	-	psi-mi:"MI:0088"(primer specific pcr)	psi-mi:"MI:0088"(primer specific pcr)
ensembl:ENSG00000131482	uniprotkb:P20393	intact:EBI-3989621	intact:EBI-2811738|uniprotkb:Q15304|uniprotkb:Q0P5Z4|ensembl:ENSP00000246672	psi-mi:g6pc_human_gene(display_short)|psi-mi:ENSG00000131482(display_long)	psi-mi:nr1d1_human(display_long)|uniprotkb:NR1D1(gene name)|psi-mi:NR1D1(display_short)|uniprotkb:EAR1(gene name synonym)|uniprotkb:HREV(gene name synonym)|uniprotkb:THRAL(gene name synonym)|uniprotkb:Rev-erbA-alpha(gene name synonym)|uniprotkb:V-erbA-related protein 1(gene name synonym)	psi-mi:"MI:0402"(chromatin immunoprecipitation assay)	Li et al. (2014)	pubmed:24311788|imex:IM-23199	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9845561|imex:IM-23199-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0250"(gene)	psi-mi:"MI:0326"(protein)	-	refseq:NP_068370.1|ensembl:ENSG00000126368(gene)|ensembl:ENST00000246672(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001678"(cellular glucose homeostasis)|go:"GO:0003707"(steroid hormone receptor activity)|go:"GO:0004879"(nuclear receptor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005978"(glycogen biosynthetic process)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010498"(proteasomal protein catabolic process)|go:"GO:0016604"(nuclear body)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0020037"(heme binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030425"(dendrite)|go:"GO:0031648"(protein destabilization)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0009755"(hormone-mediated signaling pathway)|go:"GO:0034144"(negative regulation of toll-like receptor 4 signaling pathway)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0042749"(regulation of circadian sleep/wake cycle)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043197"(dendritic spine)|go:"GO:0044321"(response to leptin)|go:"GO:0045598"(regulation of fat cell differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0060086"(circadian temperature homeostasis)|go:"GO:0061178"(regulation of insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0061469"(regulation of type B pancreatic cell proliferation)|go:"GO:0061889"(negative regulation of astrocyte activation)|go:"GO:0070859"(positive regulation of bile acid biosynthetic process)|go:"GO:0070888"(E-box binding)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|go:"GO:0150079"(negative regulation of neuroinflammatory response)|go:"GO:1903979"(negative regulation of microglial cell activation)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000536(Nuclear hormone receptor, ligand-binding, core)|interpro:IPR001628(Zinc finger, nuclear hormone receptor-type)|interpro:IPR001723(Steroid hormone receptor)|interpro:IPR013088(Zinc finger, NHR/GATA-type)|interpro:IPR035500|rcsb pdb:1A6Y|rcsb pdb:1EF6|rcsb pdb:1GA5|rcsb pdb:1HLZ|rcsb pdb:3N00|reactome:R-HSA-1368071|reactome:R-HSA-1989781|reactome:R-HSA-2151201|reactome:R-HSA-383280|reactome:R-HSA-400253|reactome:R-HSA-9707616|dip:DIP-48396N	go:"GO:0005634"(nucleus)	-	-	figure legend:5A|causality statement:P06727 and P20393  decreases expression at RNA level of  ENSG00000131482.|causality statement:P20393 decreases expression at RNA level of  ENSG00000131482.|causality statement:P20393 is required for P06727 to decrease  expression at RNA level  of ENSG00000131482 and ENSG00000100889.|causality statement:P06727  increases expression at RNA level of  ENSG00000126368.|causality statement:P06727  increases expression at protein level of  ENSG00000126368.|dataset:Cardiac - Interactions involving cardiac related proteins|dataset:Diabetes - Interactions investigated in the context of Diabetes|dataset:Affinomics - Interactions curated for the Affinomics consortium.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hep_g2)|taxid:9606("Homo sapiens hepatocellular carcinoma (HCC) cells (p53-wt).")	-	2014/10/13	2014/10/16	-	rogid:UfaVQzUQ3wD4xDBh1sjp+eaawY89606	intact-crc:42E7284770F385D0	false	sufficient binding region:?-?	-	-	-	psi-mi:"MI:0088"(primer specific pcr)	psi-mi:"MI:0088"(primer specific pcr)
uniprotkb:P06727	uniprotkb:P20393	intact:EBI-1222447|uniprotkb:Q14CW8|uniprotkb:Q6Q787|uniprotkb:A8MSL6|ensembl:ENSP00000350425	intact:EBI-2811738|uniprotkb:Q15304|uniprotkb:Q0P5Z4|ensembl:ENSP00000246672	psi-mi:apoa4_human(display_long)|uniprotkb:APOA4(gene name)|psi-mi:APOA4(display_short)|uniprotkb:Apolipoprotein A4(gene name synonym)	psi-mi:nr1d1_human(display_long)|uniprotkb:NR1D1(gene name)|psi-mi:NR1D1(display_short)|uniprotkb:EAR1(gene name synonym)|uniprotkb:HREV(gene name synonym)|uniprotkb:THRAL(gene name synonym)|uniprotkb:Rev-erbA-alpha(gene name synonym)|uniprotkb:V-erbA-related protein 1(gene name synonym)	psi-mi:"MI:0663"(confocal microscopy)	Li et al. (2014)	pubmed:24311788|imex:IM-23199	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9845202|imex:IM-23199-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000473.2|dip:DIP-38333N|ensembl:ENSG00000110244(gene)|ensembl:ENST00000357780(transcript)|go:"GO:0002227"(innate immune response in mucosa)|go:"GO:0005319"(lipid transporter activity)|go:"GO:0005507"(copper ion binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005769"(early endosome)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005829"(cytosol)|go:"GO:0006695"(cholesterol biosynthetic process)|go:"GO:0006869"(lipid transport)|go:"GO:0006982"(response to lipid hydroperoxide)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0008203"(cholesterol metabolic process)|go:"GO:0008289"(lipid binding)|go:"GO:0010873"(positive regulation of cholesterol esterification)|go:"GO:0010898"(positive regulation of triglyceride catabolic process)|go:"GO:0015485"(cholesterol binding)|go:"GO:0016042"(lipid catabolic process)|go:"GO:0016209"(antioxidant activity)|go:"GO:0019430"(removal of superoxide radicals)|go:"GO:0030300"(regulation of intestinal cholesterol absorption)|go:"GO:0031210"(phosphatidylcholine binding)|go:"GO:0032374"(regulation of cholesterol transport)|go:"GO:0033344"(cholesterol efflux)|go:"GO:0033700"(phospholipid efflux)|go:"GO:0034361"(very-low-density lipoprotein particle)|go:"GO:0034364"(high-density lipoprotein particle)|go:"GO:0034371"(chylomicron remodeling)|go:"GO:0034372"(very-low-density lipoprotein particle remodeling)|go:"GO:0034375"(high-density lipoprotein particle remodeling)|go:"GO:0034378"(chylomicron assembly)|go:"GO:0034380"(high-density lipoprotein particle assembly)|go:"GO:0034445"(negative regulation of plasma lipoprotein oxidation)|go:"GO:0035634"(response to stilbenoid)|go:"GO:0042157"(lipoprotein metabolic process)|go:"GO:0042627"(chylomicron)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0042744"(hydrogen peroxide catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043691"(reverse cholesterol transport)|go:"GO:0045723"(positive regulation of fatty acid biosynthetic process)|go:"GO:0046470"(phosphatidylcholine metabolic process)|go:"GO:0046889"(positive regulation of lipid biosynthetic process)|go:"GO:0051006"(positive regulation of lipoprotein lipase activity)|go:"GO:0055088"(lipid homeostasis)|go:"GO:0060228"(phosphatidylcholine-sterol O-acyltransferase activator activity)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0065005"(protein-lipid complex assembly)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|go:"GO:0120020"(cholesterol transfer activity)|interpro:IPR000074(Apolipoprotein A1/A4/E)|rcsb pdb:3S84|reactome:R-HSA-8963888|reactome:R-HSA-8963889|reactome:R-HSA-8963901|reactome:R-HSA-975634|reactome:R-HSA-977225|go:"GO:0070328"(triglyceride homeostasis)	refseq:NP_068370.1|ensembl:ENSG00000126368(gene)|ensembl:ENST00000246672(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001678"(cellular glucose homeostasis)|go:"GO:0003707"(steroid hormone receptor activity)|go:"GO:0004879"(nuclear receptor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005978"(glycogen biosynthetic process)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010498"(proteasomal protein catabolic process)|go:"GO:0016604"(nuclear body)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0020037"(heme binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030425"(dendrite)|go:"GO:0031648"(protein destabilization)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0009755"(hormone-mediated signaling pathway)|go:"GO:0034144"(negative regulation of toll-like receptor 4 signaling pathway)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0042749"(regulation of circadian sleep/wake cycle)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043197"(dendritic spine)|go:"GO:0044321"(response to leptin)|go:"GO:0045598"(regulation of fat cell differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0060086"(circadian temperature homeostasis)|go:"GO:0061178"(regulation of insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0061469"(regulation of type B pancreatic cell proliferation)|go:"GO:0061889"(negative regulation of astrocyte activation)|go:"GO:0070859"(positive regulation of bile acid biosynthetic process)|go:"GO:0070888"(E-box binding)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|go:"GO:0150079"(negative regulation of neuroinflammatory response)|go:"GO:1903979"(negative regulation of microglial cell activation)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000536(Nuclear hormone receptor, ligand-binding, core)|interpro:IPR001628(Zinc finger, nuclear hormone receptor-type)|interpro:IPR001723(Steroid hormone receptor)|interpro:IPR013088(Zinc finger, NHR/GATA-type)|interpro:IPR035500|rcsb pdb:1A6Y|rcsb pdb:1EF6|rcsb pdb:1GA5|rcsb pdb:1HLZ|rcsb pdb:3N00|reactome:R-HSA-1368071|reactome:R-HSA-1989781|reactome:R-HSA-2151201|reactome:R-HSA-383280|reactome:R-HSA-400253|reactome:R-HSA-9707616|dip:DIP-48396N	go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)	-	-	figure legend:4A|dataset:Cardiac - Interactions involving cardiac related proteins|dataset:Diabetes - Interactions investigated in the context of Diabetes|dataset:Affinomics - Interactions curated for the Affinomics consortium.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hep_g2)|taxid:9606("Homo sapiens hepatocellular carcinoma (HCC) cells (p53-wt).")	-	2014/10/13	2020/06/18	rogid:95b7Xlqg/plh9/R7xhLBsMXQscM9606	rogid:UfaVQzUQ3wD4xDBh1sjp+eaawY89606	intact-crc:2E3FEBE2F19EB117|rigid:uPYT74LtVJvlroLLex8NvjpH5zM	false	green fluorescent protein tag:?-?|his tag:n-n	-	-	-	psi-mi:"MI:1200"(immunocytochemistry)	psi-mi:"MI:1200"(immunocytochemistry)
uniprotkb:P06727	uniprotkb:P20393	intact:EBI-1222447|uniprotkb:Q14CW8|uniprotkb:Q6Q787|uniprotkb:A8MSL6|ensembl:ENSP00000350425	intact:EBI-2811738|uniprotkb:Q15304|uniprotkb:Q0P5Z4|ensembl:ENSP00000246672	psi-mi:apoa4_human(display_long)|uniprotkb:APOA4(gene name)|psi-mi:APOA4(display_short)|uniprotkb:Apolipoprotein A4(gene name synonym)	psi-mi:nr1d1_human(display_long)|uniprotkb:NR1D1(gene name)|psi-mi:NR1D1(display_short)|uniprotkb:EAR1(gene name synonym)|uniprotkb:HREV(gene name synonym)|uniprotkb:THRAL(gene name synonym)|uniprotkb:Rev-erbA-alpha(gene name synonym)|uniprotkb:V-erbA-related protein 1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Li et al. (2014)	pubmed:24311788|imex:IM-23199	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9845543|imex:IM-23199-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000473.2|dip:DIP-38333N|ensembl:ENSG00000110244(gene)|ensembl:ENST00000357780(transcript)|go:"GO:0002227"(innate immune response in mucosa)|go:"GO:0005319"(lipid transporter activity)|go:"GO:0005507"(copper ion binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005769"(early endosome)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005829"(cytosol)|go:"GO:0006695"(cholesterol biosynthetic process)|go:"GO:0006869"(lipid transport)|go:"GO:0006982"(response to lipid hydroperoxide)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0008203"(cholesterol metabolic process)|go:"GO:0008289"(lipid binding)|go:"GO:0010873"(positive regulation of cholesterol esterification)|go:"GO:0010898"(positive regulation of triglyceride catabolic process)|go:"GO:0015485"(cholesterol binding)|go:"GO:0016042"(lipid catabolic process)|go:"GO:0016209"(antioxidant activity)|go:"GO:0019430"(removal of superoxide radicals)|go:"GO:0030300"(regulation of intestinal cholesterol absorption)|go:"GO:0031210"(phosphatidylcholine binding)|go:"GO:0032374"(regulation of cholesterol transport)|go:"GO:0033344"(cholesterol efflux)|go:"GO:0033700"(phospholipid efflux)|go:"GO:0034361"(very-low-density lipoprotein particle)|go:"GO:0034364"(high-density lipoprotein particle)|go:"GO:0034371"(chylomicron remodeling)|go:"GO:0034372"(very-low-density lipoprotein particle remodeling)|go:"GO:0034375"(high-density lipoprotein particle remodeling)|go:"GO:0034378"(chylomicron assembly)|go:"GO:0034380"(high-density lipoprotein particle assembly)|go:"GO:0034445"(negative regulation of plasma lipoprotein oxidation)|go:"GO:0035634"(response to stilbenoid)|go:"GO:0042157"(lipoprotein metabolic process)|go:"GO:0042627"(chylomicron)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0042744"(hydrogen peroxide catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043691"(reverse cholesterol transport)|go:"GO:0045723"(positive regulation of fatty acid biosynthetic process)|go:"GO:0046470"(phosphatidylcholine metabolic process)|go:"GO:0046889"(positive regulation of lipid biosynthetic process)|go:"GO:0051006"(positive regulation of lipoprotein lipase activity)|go:"GO:0055088"(lipid homeostasis)|go:"GO:0060228"(phosphatidylcholine-sterol O-acyltransferase activator activity)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0065005"(protein-lipid complex assembly)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|go:"GO:0120020"(cholesterol transfer activity)|interpro:IPR000074(Apolipoprotein A1/A4/E)|rcsb pdb:3S84|reactome:R-HSA-8963888|reactome:R-HSA-8963889|reactome:R-HSA-8963901|reactome:R-HSA-975634|reactome:R-HSA-977225|go:"GO:0070328"(triglyceride homeostasis)	refseq:NP_068370.1|ensembl:ENSG00000126368(gene)|ensembl:ENST00000246672(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001678"(cellular glucose homeostasis)|go:"GO:0003707"(steroid hormone receptor activity)|go:"GO:0004879"(nuclear receptor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005978"(glycogen biosynthetic process)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010498"(proteasomal protein catabolic process)|go:"GO:0016604"(nuclear body)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0020037"(heme binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030425"(dendrite)|go:"GO:0031648"(protein destabilization)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0009755"(hormone-mediated signaling pathway)|go:"GO:0034144"(negative regulation of toll-like receptor 4 signaling pathway)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0042749"(regulation of circadian sleep/wake cycle)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043197"(dendritic spine)|go:"GO:0044321"(response to leptin)|go:"GO:0045598"(regulation of fat cell differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0060086"(circadian temperature homeostasis)|go:"GO:0061178"(regulation of insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0061469"(regulation of type B pancreatic cell proliferation)|go:"GO:0061889"(negative regulation of astrocyte activation)|go:"GO:0070859"(positive regulation of bile acid biosynthetic process)|go:"GO:0070888"(E-box binding)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|go:"GO:0150079"(negative regulation of neuroinflammatory response)|go:"GO:1903979"(negative regulation of microglial cell activation)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000536(Nuclear hormone receptor, ligand-binding, core)|interpro:IPR001628(Zinc finger, nuclear hormone receptor-type)|interpro:IPR001723(Steroid hormone receptor)|interpro:IPR013088(Zinc finger, NHR/GATA-type)|interpro:IPR035500|rcsb pdb:1A6Y|rcsb pdb:1EF6|rcsb pdb:1GA5|rcsb pdb:1HLZ|rcsb pdb:3N00|reactome:R-HSA-1368071|reactome:R-HSA-1989781|reactome:R-HSA-2151201|reactome:R-HSA-383280|reactome:R-HSA-400253|reactome:R-HSA-9707616|dip:DIP-48396N	go:"GO:0005634"(nucleus)	-	-	figure legend:5A|dataset:Cardiac - Interactions involving cardiac related proteins|dataset:Diabetes - Interactions investigated in the context of Diabetes|dataset:Affinomics - Interactions curated for the Affinomics consortium.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hep_g2)|taxid:9606("Homo sapiens hepatocellular carcinoma (HCC) cells (p53-wt).")	-	2014/10/13	2020/06/18	rogid:95b7Xlqg/plh9/R7xhLBsMXQscM9606	rogid:UfaVQzUQ3wD4xDBh1sjp+eaawY89606	intact-crc:100050A1A3553D70|rigid:uPYT74LtVJvlroLLex8NvjpH5zM	false	green fluorescent protein tag:?-?|his tag:n-n	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)