#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P25962	uniprotkb:P51637	intact:EBI-7406111|intact:MINT-146553|uniprotkb:Q9QZ98|uniprotkb:A2RS74|ensembl:ENSMUSP00000080162|ensembl:ENSMUSP00000113006	intact:EBI-298576|ensembl:ENSMUSP00000074922	psi-mi:adrb3_mouse(display_long)|uniprotkb:Adrb3(gene name)|psi-mi:Adrb3(display_short)|uniprotkb:Adrb3r(gene name synonym)|uniprotkb:B3bar(gene name synonym)|uniprotkb:Beta-3 adrenoreceptor(gene name synonym)	psi-mi:cav3_mouse(display_long)|uniprotkb:Cav3(gene name)|psi-mi:Cav3(display_short)|uniprotkb:M-caveolin(gene name synonym)	psi-mi:"MI:0813"(proximity ligation assay)	Belge et al. (2014)	imex:IM-22310|pubmed:24190960	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9350396|imex:IM-22310-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011240418.1|refseq:XP_011240419.1|refseq:NP_038490.2|refseq:XP_017168014.1|refseq:XP_006509050.1|refseq:XP_006509051.1|ensembl:ENSMUSG00000031489(gene)|ensembl:ENSMUST00000081438(transcript)|ensembl:ENSMUST00000121838(transcript)|go:"GO:0002024"(diet induced thermogenesis)|go:"GO:0002025"(norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0004939"(beta-adrenergic receptor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007190"(activation of adenylate cyclase activity)|go:"GO:0007568"(aging)|go:"GO:0009409"(response to cold)|go:"GO:0015052"(beta3-adrenergic receptor activity)|go:"GO:0016020"(membrane)|go:"GO:0031649"(heat generation)|go:"GO:0031699"(beta-3 adrenergic receptor binding)|go:"GO:0040015"(negative regulation of multicellular organism growth)|go:"GO:0042755"(eating behavior)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043235"(receptor complex)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0046677"(response to antibiotic)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0051379"(epinephrine binding)|go:"GO:0051380"(norepinephrine binding)|go:"GO:0071880"(adenylate cyclase-activating adrenergic receptor signaling pathway)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR000681(Adrenergic receptor, beta 3)|interpro:IPR002233(Adrenergic receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|reactome:R-MMU-390696|reactome:R-MMU-418555	go:"GO:2000649"(regulation of sodium ion transmembrane transporter activity)|go:"GO:0051480"(regulation of cytosolic calcium ion concentration)|go:"GO:0051647"(nucleus localization)|go:"GO:0051896"(regulation of protein kinase B signaling)|go:"GO:0051924"(regulation of calcium ion transport)|go:"GO:0051926"(negative regulation of calcium ion transport)|go:"GO:0055013"(cardiac muscle cell development)|go:"GO:0055117"(regulation of cardiac muscle contraction)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0060299"(negative regulation of sarcomere organization)|go:"GO:0060307"(regulation of ventricular cardiac muscle cell membrane repolarization)|go:"GO:0060347"(heart trabecula formation)|go:"GO:0060373"(regulation of ventricular cardiac muscle cell membrane depolarization)|go:"GO:0060762"(regulation of branching involved in mammary gland duct morphogenesis)|go:"GO:0061052"(negative regulation of cell growth involved in cardiac muscle cell development)|go:"GO:0070836"(caveola assembly)|go:"GO:0071253"(connexin binding)|go:"GO:0071417"(cellular response to organonitrogen compound)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0086005"(ventricular cardiac muscle cell action potential)|go:"GO:0090279"(regulation of calcium ion import)|go:"GO:0098909"(regulation of cardiac muscle cell action potential involved in regulation of contraction)|go:"GO:1900744"(regulation of p38MAPK cascade)|go:"GO:1900825"(regulation of membrane depolarization during cardiac muscle cell action potential)|go:"GO:1900826"(negative regulation of membrane depolarization during cardiac muscle cell action potential)|go:"GO:1901017"(negative regulation of potassium ion transmembrane transporter activity)|go:"GO:1901019"(regulation of calcium ion transmembrane transporter activity)|go:"GO:1901380"(negative regulation of potassium ion transmembrane transport)|ensembl:ENSMUSG00000062694(gene)|ensembl:ENSMUST00000075477(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001778"(plasma membrane repair)|go:"GO:0002027"(regulation of heart rate)|go:"GO:0005246"(calcium channel regulator activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006641"(triglyceride metabolic process)|go:"GO:0006897"(endocytosis)|go:"GO:0007009"(plasma membrane organization)|go:"GO:0007015"(actin filament organization)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007520"(myoblast fusion)|go:"GO:0008016"(regulation of heart contraction)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008104"(protein localization)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009986"(cell surface)|go:"GO:0010614"(negative regulation of cardiac muscle hypertrophy)|go:"GO:0010831"(positive regulation of myotube differentiation)|go:"GO:0014704"(intercalated disc)|go:"GO:0014819"(regulation of skeletal muscle contraction)|go:"GO:0014902"(myotube differentiation)|go:"GO:0016010"(dystrophin-associated glycoprotein complex)|go:"GO:0016020"(membrane)|go:"GO:0017015"(regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0017080"(sodium channel regulator activity)|go:"GO:0019870"(potassium channel inhibitor activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0030018"(Z disc)|go:"GO:0030154"(cell differentiation)|go:"GO:0030315"(T-tubule)|go:"GO:0031116"(positive regulation of microtubule polymerization)|go:"GO:0031122"(cytoplasmic microtubule organization)|go:"GO:0031579"(membrane raft organization)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031982"(vesicle)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035995"(detection of muscle stretch)|go:"GO:0038009"(regulation of signal transduction by receptor internalization)|go:"GO:0042383"(sarcolemma)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0043014"(alpha-tubulin binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043407"(negative regulation of MAP kinase activity)|go:"GO:0043409"(negative regulation of MAPK cascade)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045792"(negative regulation of cell size)|go:"GO:0046716"(muscle cell cellular homeostasis)|go:"GO:0050998"(nitric-oxide synthase binding)|go:"GO:0051001"(negative regulation of nitric-oxide synthase activity)|go:"GO:0051394"(regulation of nerve growth factor receptor activity)|interpro:IPR001612(Caveolin)|interpro:IPR018361|interpro:IPR031091|mint:P51637|reactome:R-MMU-445355|go:"GO:2001288"(positive regulation of caveolin-mediated endocytosis)|refseq:NP_031643.1|dip:DIP-31069N	go:"GO:0005901"(caveola)	comment:mint|function:Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. Beta-3 is involved in the regulation of lipolysis and thermogenesis	-	figure legend:Figure 1D, Supp 1|comment:A weak signal was obtained.|dataset:Cardiac - Interactions involving cardiac related proteins|dataset:Affinomics - Interactions curated for the Affinomics consortium.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-cardiac myocyt)|taxid:10090(Mus musculus)	-	2014/03/04	2015/02/05	rogid:nOH59kXA05UatVpgOR6MUplErD410090	rogid:K9freRN6XcY4lMheGDyaDgx/ZT010090	intact-crc:3DAB3186920501B4|rigid:pN9iXZBKNSA2K84LEgkQHwqoz/8	false	-	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:Q9Z0J4	uniprotkb:P13945	intact:EBI-397596|uniprotkb:Q64208|uniprotkb:Q3UR10|ensembl:ENSMUSP00000120421|ensembl:ENSMUSP00000127432	intact:EBI-9350355|uniprotkb:Q4JFT4|ensembl:ENSP00000343782	psi-mi:nos1_mouse(display_long)|uniprotkb:Nos1(gene name)|psi-mi:Nos1(display_short)|uniprotkb:bNOS(gene name synonym)|uniprotkb:NOS type I(gene name synonym)|uniprotkb:Neuronal NOS(gene name synonym)|uniprotkb:Constitutive NOS(gene name synonym)|uniprotkb:NC-NOS(gene name synonym)|uniprotkb:Peptidyl-cysteine S-nitrosylase NOS1(gene name synonym)	psi-mi:adrb3_human(display_long)|uniprotkb:ADRB3(gene name)|psi-mi:ADRB3(display_short)|uniprotkb:ADRB3R(gene name synonym)|uniprotkb:B3AR(gene name synonym)|uniprotkb:Beta-3 adrenoreceptor(gene name synonym)	psi-mi:"MI:0813"(proximity ligation assay)	Belge et al. (2014)	imex:IM-22310|pubmed:24190960	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9350429|imex:IM-22310-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_032738.1|refseq:XP_017176196.1|dip:DIP-31556N|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071872"(cellular response to epinephrine stimulus)|go:"GO:0071944"(cell periphery)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098735"(positive regulation of the force of heart contraction)|go:"GO:0098924"(retrograde trans-synaptic signaling by nitric oxide)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099091"(postsynaptic specialization, intracellular component)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:0099163"(synaptic signaling by nitric oxide)|go:"GO:0140196"(positive regulation of adenylate cyclase-activating adrenergic receptor signaling pathway involved in heart process)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1902307"(positive regulation of sodium ion transmembrane transport)|go:"GO:0070402"(NADPH binding)|go:"GO:0033017"(sarcoplasmic reticulum membrane)|go:"GO:0033137"(negative regulation of peptidyl-serine phosphorylation)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0034760"(negative regulation of iron ion transmembrane transport)|go:"GO:0035066"(positive regulation of histone acetylation)|go:"GO:0042311"(vasodilation)|go:"GO:0042383"(sarcolemma)|go:"GO:0042582"(azurophil granule)|go:"GO:0042738"|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043197"(dendritic spine)|go:"GO:0043267"(negative regulation of potassium ion transport)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043627"(response to estrogen)|go:"GO:0044305"(calyx of Held)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045202"(synapse)|go:"GO:0045776"(negative regulation of blood pressure)|go:"GO:0045822"(negative regulation of heart contraction)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045906"(negative regulation of vasoconstriction)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046676"(negative regulation of insulin secretion)|go:"GO:0046870"(cadmium ion binding)|go:"GO:0048148"(behavioral response to cocaine)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050660"(flavin adenine dinucleotide binding)|go:"GO:0050661"(NADP binding)|go:"GO:0050767"(regulation of neurogenesis)|go:"GO:0051117"(ATPase binding)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051346"(negative regulation of hydrolase activity)|go:"GO:0051481"(negative regulation of cytosolic calcium ion concentration)|go:"GO:0051612"(negative regulation of serotonin uptake)|go:"GO:0051926"(negative regulation of calcium ion transport)|go:"GO:0051930"(regulation of sensory perception of pain)|go:"GO:0061875"(negative regulation of hepatic stellate cell contraction)|go:"GO:0032991"(protein-containing complex)|interpro:IPR001433("Oxidoreductase FAD/NAD(P)-binding")|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001709(Flavoprotein pyridine nucleotide cytochrome reductase)|interpro:IPR003097(FAD-binding, type 1)|interpro:IPR004030(Nitric oxide synthase, oxygenase region)|interpro:IPR008254(Flavodoxin/nitric oxide synthase)|interpro:IPR012144(Nitric-oxide synthase)|interpro:IPR017927|interpro:IPR017938|interpro:IPR023173|interpro:IPR029039|interpro:IPR036034|interpro:IPR036119|interpro:IPR001094(Flavodoxin-like)|interpro:IPR039261|rcsb pdb:2O60|reactome:R-MMU-1222556|reactome:R-MMU-392154|reactome:R-MMU-5578775|ensembl:ENSMUSG00000029361(gene)|ensembl:ENSMUST00000142742(transcript)|ensembl:ENSMUST00000171055(transcript)|go:"GO:0001917"(photoreceptor inner segment)|go:"GO:0002028"(regulation of sodium ion transport)|go:"GO:0004517"(nitric-oxide synthase activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0006527"(arginine catabolic process)|go:"GO:0006809"(nitric oxide biosynthetic process)|go:"GO:0006936"(muscle contraction)|go:"GO:0006941"(striated muscle contraction)|go:"GO:0007263"(nitric oxide mediated signal transduction)|go:"GO:0008016"(regulation of heart contraction)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009408"(response to heat)|go:"GO:0009725"(response to hormone)|go:"GO:0010181"(FMN binding)|go:"GO:0012506"(vesicle membrane)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016491"(oxidoreductase activity)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0016709"("oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen")|go:"GO:0017080"(sodium channel regulator activity)|go:"GO:0018119"(peptidyl-cysteine S-nitrosylation)|go:"GO:0019899"(enzyme binding)|go:"GO:0020037"(heme binding)|go:"GO:0030018"(Z disc)|go:"GO:0030141"(secretory granule)|go:"GO:0030315"(T-tubule)|go:"GO:0030425"(dendrite)|go:"GO:0031284"(positive regulation of guanylate cyclase activity)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032496"(response to lipopolysaccharide)	refseq:NP_000016.1|dip:DIP-61451N|ensembl:ENSG00000188778(gene)|ensembl:ENST00000345060(transcript)|go:"GO:0002025"(norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0004939"(beta-adrenergic receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005975"(carbohydrate metabolic process)|go:"GO:0006091"(generation of precursor metabolites and energy)|go:"GO:0006112"(energy reserve metabolic process)|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|go:"GO:0007188"(adenylate cyclase-modulating G protein-coupled receptor signaling pathway)|go:"GO:0007190"(activation of adenylate cyclase activity)|go:"GO:0015052"(beta3-adrenergic receptor activity)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043235"(receptor complex)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0051379"(epinephrine binding)|go:"GO:0071880"(adenylate cyclase-activating adrenergic receptor signaling pathway)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR000681(Adrenergic receptor, beta 3)|interpro:IPR002233(Adrenergic receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|rcsb pdb:2CDW|reactome:R-HSA-390696|reactome:R-HSA-418555|reactome:R-HSA-9660821	go:"GO:0005901"(caveola)	-	-	figure legend:Supp 3.|dataset:Cardiac - Interactions involving cardiac related proteins|dataset:Affinomics - Interactions curated for the Affinomics consortium.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-cardiac myocyt)|taxid:10090(Mus musculus)	-	2014/03/04	2014/10/16	rogid:BuPBvQk0jEhDNZNi82D3OidmYwE10090	rogid:6OfufQn0hoDjGnziUZTuvGTg5eg9606	intact-crc:DDD4A26294E6B144|rigid:s+T47pN+64YnCBS2QION4OQHwi8	false	-	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:P51637	uniprotkb:P13945	intact:EBI-298576|ensembl:ENSMUSP00000074922	intact:EBI-9350355|uniprotkb:Q4JFT4|ensembl:ENSP00000343782	psi-mi:cav3_mouse(display_long)|uniprotkb:Cav3(gene name)|psi-mi:Cav3(display_short)|uniprotkb:M-caveolin(gene name synonym)	psi-mi:adrb3_human(display_long)|uniprotkb:ADRB3(gene name)|psi-mi:ADRB3(display_short)|uniprotkb:ADRB3R(gene name synonym)|uniprotkb:B3AR(gene name synonym)|uniprotkb:Beta-3 adrenoreceptor(gene name synonym)	psi-mi:"MI:0813"(proximity ligation assay)	Belge et al. (2014)	imex:IM-22310|pubmed:24190960	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9350352|imex:IM-22310-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:2000649"(regulation of sodium ion transmembrane transporter activity)|go:"GO:0051480"(regulation of cytosolic calcium ion concentration)|go:"GO:0051647"(nucleus localization)|go:"GO:0051896"(regulation of protein kinase B signaling)|go:"GO:0051924"(regulation of calcium ion transport)|go:"GO:0051926"(negative regulation of calcium ion transport)|go:"GO:0055013"(cardiac muscle cell development)|go:"GO:0055117"(regulation of cardiac muscle contraction)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0060299"(negative regulation of sarcomere organization)|go:"GO:0060307"(regulation of ventricular cardiac muscle cell membrane repolarization)|go:"GO:0060347"(heart trabecula formation)|go:"GO:0060373"(regulation of ventricular cardiac muscle cell membrane depolarization)|go:"GO:0060762"(regulation of branching involved in mammary gland duct morphogenesis)|go:"GO:0061052"(negative regulation of cell growth involved in cardiac muscle cell development)|go:"GO:0070836"(caveola assembly)|go:"GO:0071253"(connexin binding)|go:"GO:0071417"(cellular response to organonitrogen compound)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0086005"(ventricular cardiac muscle cell action potential)|go:"GO:0090279"(regulation of calcium ion import)|go:"GO:0098909"(regulation of cardiac muscle cell action potential involved in regulation of contraction)|go:"GO:1900744"(regulation of p38MAPK cascade)|go:"GO:1900825"(regulation of membrane depolarization during cardiac muscle cell action potential)|go:"GO:1900826"(negative regulation of membrane depolarization during cardiac muscle cell action potential)|go:"GO:1901017"(negative regulation of potassium ion transmembrane transporter activity)|go:"GO:1901019"(regulation of calcium ion transmembrane transporter activity)|go:"GO:1901380"(negative regulation of potassium ion transmembrane transport)|ensembl:ENSMUSG00000062694(gene)|ensembl:ENSMUST00000075477(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001778"(plasma membrane repair)|go:"GO:0002027"(regulation of heart rate)|go:"GO:0005246"(calcium channel regulator activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006641"(triglyceride metabolic process)|go:"GO:0006897"(endocytosis)|go:"GO:0007009"(plasma membrane organization)|go:"GO:0007015"(actin filament organization)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007520"(myoblast fusion)|go:"GO:0008016"(regulation of heart contraction)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008104"(protein localization)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009986"(cell surface)|go:"GO:0010614"(negative regulation of cardiac muscle hypertrophy)|go:"GO:0010831"(positive regulation of myotube differentiation)|go:"GO:0014704"(intercalated disc)|go:"GO:0014819"(regulation of skeletal muscle contraction)|go:"GO:0014902"(myotube differentiation)|go:"GO:0016010"(dystrophin-associated glycoprotein complex)|go:"GO:0016020"(membrane)|go:"GO:0017015"(regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0017080"(sodium channel regulator activity)|go:"GO:0019870"(potassium channel inhibitor activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0030018"(Z disc)|go:"GO:0030154"(cell differentiation)|go:"GO:0030315"(T-tubule)|go:"GO:0031116"(positive regulation of microtubule polymerization)|go:"GO:0031122"(cytoplasmic microtubule organization)|go:"GO:0031579"(membrane raft organization)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031982"(vesicle)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035995"(detection of muscle stretch)|go:"GO:0038009"(regulation of signal transduction by receptor internalization)|go:"GO:0042383"(sarcolemma)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0043014"(alpha-tubulin binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043407"(negative regulation of MAP kinase activity)|go:"GO:0043409"(negative regulation of MAPK cascade)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045792"(negative regulation of cell size)|go:"GO:0046716"(muscle cell cellular homeostasis)|go:"GO:0050998"(nitric-oxide synthase binding)|go:"GO:0051001"(negative regulation of nitric-oxide synthase activity)|go:"GO:0051394"(regulation of nerve growth factor receptor activity)|interpro:IPR001612(Caveolin)|interpro:IPR018361|interpro:IPR031091|mint:P51637|reactome:R-MMU-445355|go:"GO:2001288"(positive regulation of caveolin-mediated endocytosis)|refseq:NP_031643.1|dip:DIP-31069N	refseq:NP_000016.1|dip:DIP-61451N|ensembl:ENSG00000188778(gene)|ensembl:ENST00000345060(transcript)|go:"GO:0002025"(norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0004939"(beta-adrenergic receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005975"(carbohydrate metabolic process)|go:"GO:0006091"(generation of precursor metabolites and energy)|go:"GO:0006112"(energy reserve metabolic process)|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|go:"GO:0007188"(adenylate cyclase-modulating G protein-coupled receptor signaling pathway)|go:"GO:0007190"(activation of adenylate cyclase activity)|go:"GO:0015052"(beta3-adrenergic receptor activity)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043235"(receptor complex)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0051379"(epinephrine binding)|go:"GO:0071880"(adenylate cyclase-activating adrenergic receptor signaling pathway)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR000681(Adrenergic receptor, beta 3)|interpro:IPR002233(Adrenergic receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|rcsb pdb:2CDW|reactome:R-HSA-390696|reactome:R-HSA-418555|reactome:R-HSA-9660821	go:"GO:0005901"(caveola)	-	-	figure legend:1D,  Supp 1.|dataset:Cardiac - Interactions involving cardiac related proteins|dataset:Affinomics - Interactions curated for the Affinomics consortium.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-cardiac myocyt)|taxid:10090(Mus musculus)	-	2014/03/04	2014/10/16	rogid:K9freRN6XcY4lMheGDyaDgx/ZT010090	rogid:6OfufQn0hoDjGnziUZTuvGTg5eg9606	intact-crc:230128F1A0EDAA55|rigid:pTIG/5qQpFqsu7KOZ4l0/WjoqZ0	false	-	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)
uniprotkb:P13945	uniprotkb:P70313	intact:EBI-9350355|uniprotkb:Q4JFT4|ensembl:ENSP00000343782	intact:EBI-298920|ensembl:ENSMUSP00000030834|uniprotkb:O55056|uniprotkb:Q7TSV7	psi-mi:adrb3_human(display_long)|uniprotkb:ADRB3(gene name)|psi-mi:ADRB3(display_short)|uniprotkb:ADRB3R(gene name synonym)|uniprotkb:B3AR(gene name synonym)|uniprotkb:Beta-3 adrenoreceptor(gene name synonym)	psi-mi:nos3_mouse(display_long)|uniprotkb:Nos3(gene name)|psi-mi:Nos3(display_short)|uniprotkb:Ecnos(gene name synonym)|uniprotkb:Endothelial NOS(gene name synonym)|uniprotkb:EC-NOS(gene name synonym)|uniprotkb:NOS type III(gene name synonym)|uniprotkb:Constitutive NOS(gene name synonym)	psi-mi:"MI:0813"(proximity ligation assay)	Belge et al. (2014)	imex:IM-22310|pubmed:24190960	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9350424|imex:IM-22310-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000016.1|dip:DIP-61451N|ensembl:ENSG00000188778(gene)|ensembl:ENST00000345060(transcript)|go:"GO:0002025"(norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0004939"(beta-adrenergic receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005975"(carbohydrate metabolic process)|go:"GO:0006091"(generation of precursor metabolites and energy)|go:"GO:0006112"(energy reserve metabolic process)|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|go:"GO:0007188"(adenylate cyclase-modulating G protein-coupled receptor signaling pathway)|go:"GO:0007190"(activation of adenylate cyclase activity)|go:"GO:0015052"(beta3-adrenergic receptor activity)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043235"(receptor complex)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0051379"(epinephrine binding)|go:"GO:0071880"(adenylate cyclase-activating adrenergic receptor signaling pathway)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR000681(Adrenergic receptor, beta 3)|interpro:IPR002233(Adrenergic receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|rcsb pdb:2CDW|reactome:R-HSA-390696|reactome:R-HSA-418555|reactome:R-HSA-9660821	ensembl:ENSMUSG00000028978(gene)|ensembl:ENSMUST00000030834(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001542"(ovulation from ovarian follicle)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001974"(blood vessel remodeling)|go:"GO:0002028"(regulation of sodium ion transport)|go:"GO:0003057"(regulation of the force of heart contraction by chemical signal)|go:"GO:0003100"(regulation of systemic arterial blood pressure by endothelin)|go:"GO:0003180"(aortic valve morphogenesis)|go:"GO:0003184"(pulmonary valve morphogenesis)|go:"GO:0003203"(endocardial cushion morphogenesis)|go:"GO:0003779"(actin binding)|go:"GO:0003785"(actin monomer binding)|go:"GO:0004517"(nitric-oxide synthase activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006527"(arginine catabolic process)|go:"GO:0006809"(nitric oxide biosynthetic process)|go:"GO:0007165"(signal transduction)|go:"GO:0007263"(nitric oxide mediated signal transduction)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009725"(response to hormone)|go:"GO:0010181"(FMN binding)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0012506"(vesicle membrane)|go:"GO:0014740"(negative regulation of muscle hyperplasia)|go:"GO:0014806"(smooth muscle hyperplasia)|go:"GO:0016491"(oxidoreductase activity)|go:"GO:0016709"("oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen")|go:"GO:0019430"(removal of superoxide radicals)|go:"GO:0020037"(heme binding)|go:"GO:0030324"(lung development)|go:"GO:0031284"(positive regulation of guanylate cyclase activity)|go:"GO:0031644"(regulation of nervous system process)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032355"(response to estradiol)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034617"(tetrahydrobiopterin binding)|go:"GO:0034618"(arginine binding)|go:"GO:0042383"(sarcolemma)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043267"(negative regulation of potassium ion transport)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0043542"(endothelial cell migration)|go:"GO:0045121"(membrane raft)|go:"GO:0045177"(apical part of cell)|go:"GO:0045296"(cadherin binding)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045776"(negative regulation of blood pressure)|go:"GO:0046872"(metal ion binding)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:0048873"(homeostasis of number of cells within a tissue)|go:"GO:0050660"(flavin adenine dinucleotide binding)|go:"GO:0050661"(NADP binding)|go:"GO:0050998"(nitric-oxide synthase binding)|go:"GO:0051346"(negative regulation of hydrolase activity)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0051926"(negative regulation of calcium ion transport)|go:"GO:0060412"(ventricular septum morphogenesis)|go:"GO:0070168"(negative regulation of biomineral tissue development)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097746"(blood vessel diameter maintenance)|interpro:IPR001094(Flavodoxin-like)|interpro:IPR001433("Oxidoreductase FAD/NAD(P)-binding")|interpro:IPR001709(Flavoprotein pyridine nucleotide cytochrome reductase)|interpro:IPR003097(FAD-binding, type 1)|interpro:IPR004030(Nitric oxide synthase, oxygenase region)|interpro:IPR008254(Flavodoxin/nitric oxide synthase)|interpro:IPR012144(Nitric-oxide synthase)|interpro:IPR017927|interpro:IPR017938|interpro:IPR023173|interpro:IPR029039|interpro:IPR036119|interpro:IPR039261|reactome:R-MMU-1222556|reactome:R-MMU-1474151|reactome:R-MMU-203615|reactome:R-MMU-203641|reactome:R-MMU-203754|reactome:R-MMU-392154|reactome:R-MMU-5218920|reactome:R-MMU-9009391|refseq:NP_032739.3|dip:DIP-31086N	go:"GO:0005901"(caveola)	-	-	figure legend:Supp 2.|dataset:Cardiac - Interactions involving cardiac related proteins|dataset:Affinomics - Interactions curated for the Affinomics consortium.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-cardiac myocyt)|taxid:10090(Mus musculus)	-	2014/03/04	2014/10/16	rogid:6OfufQn0hoDjGnziUZTuvGTg5eg9606	rogid:ZrCc6I1lYQVT+/No+jj0KhLkqPU10090	intact-crc:0C9268F6F216A0DE|rigid:cyG6E7oEHYFiAEOMg83Kr3w0O/0	false	-	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)