#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q9ULT6	uniprotkb:Q2MKA7	intact:EBI-949772|ensembl:ENSP00000443824|uniprotkb:B3KU18|uniprotkb:Q6ICH1|uniprotkb:Q6NTF8|uniprotkb:Q8WU18|intact:EBI-2130135	intact:EBI-10045219|uniprotkb:A2A420|uniprotkb:Q0H8S6|uniprotkb:Q14C72|uniprotkb:Q5T0F2|uniprotkb:Q8N7L5|ensembl:ENSP00000348944|ensembl:ENSP00000383846	psi-mi:znrf3_human(display_long)|uniprotkb:RING finger protein 203(gene name synonym)|uniprotkb:ZNRF3(gene name)|psi-mi:ZNRF3(display_short)|uniprotkb:KIAA1133(gene name synonym)|uniprotkb:RNF203(gene name synonym)|uniprotkb:Zinc/RING finger protein 3(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase ZNRF3(gene name synonym)	psi-mi:rspo1_human(display_long)|uniprotkb:RSPO1(gene name)|psi-mi:RSPO1(display_short)|uniprotkb:Roof plate-specific spondin-1(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Xie et al. (2013)	pubmed:24165923|imex:IM-23591	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-10045216|imex:IM-23591-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001193927.1|refseq:NP_115549.2|ensembl:ENSG00000183579(gene)|ensembl:ENST00000544604(transcript)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005109"(frizzled binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0038018"(Wnt receptor catabolic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0060173"(limb development)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0072089"(stem cell proliferation)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:2000051"(negative regulation of non-canonical Wnt signaling pathway)|go:"GO:2000095"(regulation of Wnt signaling pathway, planar cell polarity pathway)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR040700|mint:Q9ULT6|reactome:R-HSA-4641263|dip:DIP-50030N	refseq:NP_001033722.1|refseq:NP_001229837.1|refseq:NP_001229838.1|refseq:NP_001229839.1|refseq:XP_006710646.1|ensembl:ENSG00000169218(gene)|ensembl:ENST00000356545(transcript)|ensembl:ENST00000401068(transcript)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002090"(regulation of receptor internalization)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0008201"(heparin binding)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0030177"(positive regulation of Wnt signaling pathway)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|interpro:IPR000884(Thrombospondin, type I)|interpro:IPR006212(Furin-like repeat)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR036383|interpro:IPR042991|interpro:IPR043601|rcsb pdb:4BSO|rcsb pdb:4BSP|rcsb pdb:4BSR|rcsb pdb:4BSS|rcsb pdb:4BST|rcsb pdb:4BSU|rcsb pdb:4CDK|rcsb pdb:4KNG|rcsb pdb:4KT1|rcsb pdb:4LI2|rcsb pdb:4QXF|reactome:R-HSA-4641263|dip:DIP-59895N	-	-	-	figure legend:f2a|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:0.8x10^-6(molar)	2014/06/16	2015/02/09	rogid:NI0yNKDLOyZmCO7OmzAa8VPQzNM9606	rogid:+NBHcmOpvY9I2ubG2O8bLiGzmUk9606	intact-crc:8C78BA5F077903D7|rigid:yG/hCC7kXBiN+dRiOaC09tWRavo	false	binding-associated region:56-216	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q2MKA7	uniprotkb:Q9ULT6	intact:EBI-10045219|uniprotkb:A2A420|uniprotkb:Q0H8S6|uniprotkb:Q14C72|uniprotkb:Q5T0F2|uniprotkb:Q8N7L5|ensembl:ENSP00000348944|ensembl:ENSP00000383846	intact:EBI-949772|ensembl:ENSP00000443824|uniprotkb:B3KU18|uniprotkb:Q6ICH1|uniprotkb:Q6NTF8|uniprotkb:Q8WU18|intact:EBI-2130135	psi-mi:rspo1_human(display_long)|uniprotkb:RSPO1(gene name)|psi-mi:RSPO1(display_short)|uniprotkb:Roof plate-specific spondin-1(gene name synonym)	psi-mi:znrf3_human(display_long)|uniprotkb:RING finger protein 203(gene name synonym)|uniprotkb:ZNRF3(gene name)|psi-mi:ZNRF3(display_short)|uniprotkb:KIAA1133(gene name synonym)|uniprotkb:RNF203(gene name synonym)|uniprotkb:Zinc/RING finger protein 3(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase ZNRF3(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Xie et al. (2013)	pubmed:24165923|imex:IM-23591	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-10045290|imex:IM-23591-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001033722.1|refseq:NP_001229837.1|refseq:NP_001229838.1|refseq:NP_001229839.1|refseq:XP_006710646.1|ensembl:ENSG00000169218(gene)|ensembl:ENST00000356545(transcript)|ensembl:ENST00000401068(transcript)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002090"(regulation of receptor internalization)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0008201"(heparin binding)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0030177"(positive regulation of Wnt signaling pathway)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|interpro:IPR000884(Thrombospondin, type I)|interpro:IPR006212(Furin-like repeat)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR036383|interpro:IPR042991|interpro:IPR043601|rcsb pdb:4BSO|rcsb pdb:4BSP|rcsb pdb:4BSR|rcsb pdb:4BSS|rcsb pdb:4BST|rcsb pdb:4BSU|rcsb pdb:4CDK|rcsb pdb:4KNG|rcsb pdb:4KT1|rcsb pdb:4LI2|rcsb pdb:4QXF|reactome:R-HSA-4641263|dip:DIP-59895N	refseq:NP_001193927.1|refseq:NP_115549.2|ensembl:ENSG00000183579(gene)|ensembl:ENST00000544604(transcript)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005109"(frizzled binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0038018"(Wnt receptor catabolic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0060173"(limb development)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0072089"(stem cell proliferation)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:2000051"(negative regulation of non-canonical Wnt signaling pathway)|go:"GO:2000095"(regulation of Wnt signaling pathway, planar cell polarity pathway)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR040700|mint:Q9ULT6|reactome:R-HSA-4641263|dip:DIP-50030N	-	-	-	figure legend:f2c|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/16	2014/12/17	rogid:+NBHcmOpvY9I2ubG2O8bLiGzmUk9606	rogid:NI0yNKDLOyZmCO7OmzAa8VPQzNM9606	intact-crc:8C7BDA5F077903D7|rigid:yG/hCC7kXBiN+dRiOaC09tWRavo	false	-	binding-associated region:56-216|mutation disrupting interaction:103-103	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q2MKA7	uniprotkb:Q9ULT6	intact:EBI-10045219|uniprotkb:A2A420|uniprotkb:Q0H8S6|uniprotkb:Q14C72|uniprotkb:Q5T0F2|uniprotkb:Q8N7L5|ensembl:ENSP00000348944|ensembl:ENSP00000383846	intact:EBI-949772|ensembl:ENSP00000443824|uniprotkb:B3KU18|uniprotkb:Q6ICH1|uniprotkb:Q6NTF8|uniprotkb:Q8WU18|intact:EBI-2130135	psi-mi:rspo1_human(display_long)|uniprotkb:RSPO1(gene name)|psi-mi:RSPO1(display_short)|uniprotkb:Roof plate-specific spondin-1(gene name synonym)	psi-mi:znrf3_human(display_long)|uniprotkb:RING finger protein 203(gene name synonym)|uniprotkb:ZNRF3(gene name)|psi-mi:ZNRF3(display_short)|uniprotkb:KIAA1133(gene name synonym)|uniprotkb:RNF203(gene name synonym)|uniprotkb:Zinc/RING finger protein 3(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase ZNRF3(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Xie et al. (2013)	pubmed:24165923|imex:IM-23591	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-10045280|imex:IM-23591-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001033722.1|refseq:NP_001229837.1|refseq:NP_001229838.1|refseq:NP_001229839.1|refseq:XP_006710646.1|ensembl:ENSG00000169218(gene)|ensembl:ENST00000356545(transcript)|ensembl:ENST00000401068(transcript)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002090"(regulation of receptor internalization)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0008201"(heparin binding)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0030177"(positive regulation of Wnt signaling pathway)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|interpro:IPR000884(Thrombospondin, type I)|interpro:IPR006212(Furin-like repeat)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR036383|interpro:IPR042991|interpro:IPR043601|rcsb pdb:4BSO|rcsb pdb:4BSP|rcsb pdb:4BSR|rcsb pdb:4BSS|rcsb pdb:4BST|rcsb pdb:4BSU|rcsb pdb:4CDK|rcsb pdb:4KNG|rcsb pdb:4KT1|rcsb pdb:4LI2|rcsb pdb:4QXF|reactome:R-HSA-4641263|dip:DIP-59895N	refseq:NP_001193927.1|refseq:NP_115549.2|ensembl:ENSG00000183579(gene)|ensembl:ENST00000544604(transcript)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005109"(frizzled binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0038018"(Wnt receptor catabolic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0060173"(limb development)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0072089"(stem cell proliferation)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:2000051"(negative regulation of non-canonical Wnt signaling pathway)|go:"GO:2000095"(regulation of Wnt signaling pathway, planar cell polarity pathway)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR040700|mint:Q9ULT6|reactome:R-HSA-4641263|dip:DIP-50030N	-	-	-	figure legend:f2b|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/06/16	2014/12/17	rogid:+NBHcmOpvY9I2ubG2O8bLiGzmUk9606	rogid:NI0yNKDLOyZmCO7OmzAa8VPQzNM9606	intact-crc:57A231E07550A847|rigid:yG/hCC7kXBiN+dRiOaC09tWRavo	false	mutation disrupting interaction:66-66	binding-associated region:56-216	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)