#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q91WA6	uniprotkb:Q924T7	intact:EBI-646097|uniprotkb:Q7TNT3|uniprotkb:Q8CHL3|ensembl:ENSMUSP00000023211	intact:EBI-647680|ensembl:ENSMUSP00000019443	psi-mi:shrpn_mouse(display_long)|uniprotkb:Shank-associated RH domain-interacting protein(gene name synonym)|uniprotkb:Shank-interacting protein-like 1(gene name synonym)|uniprotkb:Sharpin(gene name)|psi-mi:Sharpin(display_short)|uniprotkb:Sipl1(gene name synonym)|uniprotkb:Cpdm(gene name synonym)	psi-mi:rnf31_mouse(display_long)|uniprotkb:HOIL-1-interacting protein(gene name synonym)|uniprotkb:Rnf31(gene name)|psi-mi:Rnf31(display_short)|uniprotkb:Paul(gene name synonym)|uniprotkb:Putative Ariadne-like ubiquitin ligase(gene name synonym)|uniprotkb:RING finger protein 31(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase RNF31(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Sasaki et al. (2013)	imex:IM-23566|pubmed:23942237	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-10042787|imex:IM-23566-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_079616.2|dip:DIP-49461N|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007420"(brain development)|go:"GO:0008544"(epidermis development)|go:"GO:0010803"(regulation of tumor necrosis factor-mediated signaling pathway)|go:"GO:0014069"(postsynaptic density)|go:"GO:0030262"(apoptotic nuclear changes)|go:"GO:0030425"(dendrite)|go:"GO:0031424"(keratinization)|go:"GO:0031593"(polyubiquitin modification-dependent protein binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0071797"(LUBAC complex)|go:"GO:0097039"(protein linear polyubiquitination)|go:"GO:2000348"(regulation of CD40 signaling pathway)|interpro:IPR001876(Zinc finger, RanBP2-type)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR026261|interpro:IPR029071|interpro:IPR031912|interpro:IPR036443|rcsb pdb:5Y3T|reactome:R-MMU-5357905|reactome:R-MMU-5357956|ensembl:ENSMUSG00000022552(gene)|ensembl:ENSMUST00000023211(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005829"(cytosol)	refseq:NP_919327.2|dip:DIP-49579N|reactome:R-MMU-5357905|reactome:R-MMU-5357956|rcsb pdb:5Y3T|ensembl:ENSMUSG00000047098(gene)|ensembl:ENSMUST00000019443(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005829"(cytosol)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0023035"(CD40 signaling pathway)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0035631"(CD40 receptor complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0060546"(negative regulation of necroptotic process)|go:"GO:0071797"(LUBAC complex)|go:"GO:0097039"(protein linear polyubiquitination)|interpro:IPR001876(Zinc finger, RanBP2-type)|interpro:IPR002867(Zinc finger, C6HC-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR017907|interpro:IPR018997|interpro:IPR026254|interpro:IPR032065|interpro:IPR036339|interpro:IPR036443|interpro:IPR040641|interpro:IPR041031|interpro:IPR044066	-	-	-	figure legend:f1c|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-b-cell)|taxid:10090(Mus musculus B-cell)	-	2014/12/15	2014/12/15	rogid:X0S3ADbUc34U7NHcxNjatvqgE2010090	rogid:xIbE6XjFXsobrXWbjabTL3rhhf410090	intact-crc:31FF42B979F95A98|rigid:eYdUMQ6/THKonpaAGllLUcMg7s8	false	-	binding-associated region:1-704	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q91WA6	uniprotkb:Q9WUB0	intact:EBI-646097|uniprotkb:Q7TNT3|uniprotkb:Q8CHL3|ensembl:ENSMUSP00000023211	intact:EBI-6141072|uniprotkb:A2ANR4|uniprotkb:Q3TM86|uniprotkb:Q8C2I0|ensembl:ENSMUSP00000028964|ensembl:ENSMUSP00000105473	psi-mi:shrpn_mouse(display_long)|uniprotkb:Shank-associated RH domain-interacting protein(gene name synonym)|uniprotkb:Shank-interacting protein-like 1(gene name synonym)|uniprotkb:Sharpin(gene name)|psi-mi:Sharpin(display_short)|uniprotkb:Sipl1(gene name synonym)|uniprotkb:Cpdm(gene name synonym)	psi-mi:hoil1_mouse(display_long)|uniprotkb:Rbck1(gene name)|psi-mi:Rbck1(display_short)|uniprotkb:Rbck(gene name synonym)|uniprotkb:Ubce7ip3(gene name synonym)|uniprotkb:Uip28(gene name synonym)|uniprotkb:Heme-oxidized IRP2 ubiquitin ligase 1 homolog(gene name synonym)|uniprotkb:UbcM4-interacting protein 28(gene name synonym)|uniprotkb:Ubiquitin-conjugating enzyme 7-interacting protein 3(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase HOIL-1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Sasaki et al. (2013)	imex:IM-23566|pubmed:23942237	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-10042787|imex:IM-23566-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_079616.2|dip:DIP-49461N|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007420"(brain development)|go:"GO:0008544"(epidermis development)|go:"GO:0010803"(regulation of tumor necrosis factor-mediated signaling pathway)|go:"GO:0014069"(postsynaptic density)|go:"GO:0030262"(apoptotic nuclear changes)|go:"GO:0030425"(dendrite)|go:"GO:0031424"(keratinization)|go:"GO:0031593"(polyubiquitin modification-dependent protein binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0071797"(LUBAC complex)|go:"GO:0097039"(protein linear polyubiquitination)|go:"GO:2000348"(regulation of CD40 signaling pathway)|interpro:IPR001876(Zinc finger, RanBP2-type)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR026261|interpro:IPR029071|interpro:IPR031912|interpro:IPR036443|rcsb pdb:5Y3T|reactome:R-MMU-5357905|reactome:R-MMU-5357956|ensembl:ENSMUSG00000022552(gene)|ensembl:ENSMUST00000023211(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005829"(cytosol)	refseq:NP_001077390.1|refseq:NP_062679.2|dip:DIP-59198N|ensembl:ENSMUSG00000027466(gene)|ensembl:ENSMUST00000028964(transcript)|ensembl:ENSMUST00000109847(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051220"(cytoplasmic sequestering of protein)|go:"GO:0060546"(negative regulation of necroptotic process)|go:"GO:0071797"(LUBAC complex)|go:"GO:0097039"(protein linear polyubiquitination)|go:"GO:0140311"(protein sequestering activity)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|interpro:IPR000626(Ubiquitin)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR001876(Zinc finger, RanBP2-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR026261|interpro:IPR027370|interpro:IPR029071|interpro:IPR036443|interpro:IPR044066|rcsb pdb:3B08|rcsb pdb:3B0A|rcsb pdb:5Y3T|reactome:R-MMU-5357905|reactome:R-MMU-5357956|reactome:R-MMU-983168	-	-	-	figure legend:f1c|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-b-cell)|taxid:10090(Mus musculus B-cell)	-	2014/12/15	2014/12/15	rogid:X0S3ADbUc34U7NHcxNjatvqgE2010090	rogid:BrdBce5XWr8fSk3w0rPsymbLpC410090	intact-crc:31FF42B979F95A98|rigid:eYdUMQ6/THKonpaAGllLUcMg7s8	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q91WA6	uniprotkb:Q924T7	intact:EBI-646097|uniprotkb:Q7TNT3|uniprotkb:Q8CHL3|ensembl:ENSMUSP00000023211	intact:EBI-647680|ensembl:ENSMUSP00000019443	psi-mi:shrpn_mouse(display_long)|uniprotkb:Shank-associated RH domain-interacting protein(gene name synonym)|uniprotkb:Shank-interacting protein-like 1(gene name synonym)|uniprotkb:Sharpin(gene name)|psi-mi:Sharpin(display_short)|uniprotkb:Sipl1(gene name synonym)|uniprotkb:Cpdm(gene name synonym)	psi-mi:rnf31_mouse(display_long)|uniprotkb:HOIL-1-interacting protein(gene name synonym)|uniprotkb:Rnf31(gene name)|psi-mi:Rnf31(display_short)|uniprotkb:Paul(gene name synonym)|uniprotkb:Putative Ariadne-like ubiquitin ligase(gene name synonym)|uniprotkb:RING finger protein 31(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase RNF31(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Sasaki et al. (2013)	imex:IM-23566|pubmed:23942237	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-10042787|imex:IM-23566-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_079616.2|dip:DIP-49461N|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007420"(brain development)|go:"GO:0008544"(epidermis development)|go:"GO:0010803"(regulation of tumor necrosis factor-mediated signaling pathway)|go:"GO:0014069"(postsynaptic density)|go:"GO:0030262"(apoptotic nuclear changes)|go:"GO:0030425"(dendrite)|go:"GO:0031424"(keratinization)|go:"GO:0031593"(polyubiquitin modification-dependent protein binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0071797"(LUBAC complex)|go:"GO:0097039"(protein linear polyubiquitination)|go:"GO:2000348"(regulation of CD40 signaling pathway)|interpro:IPR001876(Zinc finger, RanBP2-type)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR026261|interpro:IPR029071|interpro:IPR031912|interpro:IPR036443|rcsb pdb:5Y3T|reactome:R-MMU-5357905|reactome:R-MMU-5357956|ensembl:ENSMUSG00000022552(gene)|ensembl:ENSMUST00000023211(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005829"(cytosol)	refseq:NP_919327.2|dip:DIP-49579N|reactome:R-MMU-5357905|reactome:R-MMU-5357956|rcsb pdb:5Y3T|ensembl:ENSMUSG00000047098(gene)|ensembl:ENSMUST00000019443(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005829"(cytosol)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0023035"(CD40 signaling pathway)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0035631"(CD40 receptor complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0060546"(negative regulation of necroptotic process)|go:"GO:0071797"(LUBAC complex)|go:"GO:0097039"(protein linear polyubiquitination)|interpro:IPR001876(Zinc finger, RanBP2-type)|interpro:IPR002867(Zinc finger, C6HC-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR017907|interpro:IPR018997|interpro:IPR026254|interpro:IPR032065|interpro:IPR036339|interpro:IPR036443|interpro:IPR040641|interpro:IPR041031|interpro:IPR044066	-	-	-	figure legend:f1c|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-b-cell)|taxid:10090(Mus musculus B-cell)	-	2014/12/15	2014/12/15	rogid:X0S3ADbUc34U7NHcxNjatvqgE2010090	rogid:xIbE6XjFXsobrXWbjabTL3rhhf410090	intact-crc:31FF42B979F95A98|rigid:eYdUMQ6/THKonpaAGllLUcMg7s8	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9WUB0	uniprotkb:Q924T7	intact:EBI-6141072|uniprotkb:A2ANR4|uniprotkb:Q3TM86|uniprotkb:Q8C2I0|ensembl:ENSMUSP00000028964|ensembl:ENSMUSP00000105473	intact:EBI-647680|ensembl:ENSMUSP00000019443	psi-mi:hoil1_mouse(display_long)|uniprotkb:Rbck1(gene name)|psi-mi:Rbck1(display_short)|uniprotkb:Rbck(gene name synonym)|uniprotkb:Ubce7ip3(gene name synonym)|uniprotkb:Uip28(gene name synonym)|uniprotkb:Heme-oxidized IRP2 ubiquitin ligase 1 homolog(gene name synonym)|uniprotkb:UbcM4-interacting protein 28(gene name synonym)|uniprotkb:Ubiquitin-conjugating enzyme 7-interacting protein 3(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase HOIL-1(gene name synonym)	psi-mi:rnf31_mouse(display_long)|uniprotkb:HOIL-1-interacting protein(gene name synonym)|uniprotkb:Rnf31(gene name)|psi-mi:Rnf31(display_short)|uniprotkb:Paul(gene name synonym)|uniprotkb:Putative Ariadne-like ubiquitin ligase(gene name synonym)|uniprotkb:RING finger protein 31(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase RNF31(gene name synonym)	psi-mi:"MI:0071"(molecular sieving)	Sasaki et al. (2013)	imex:IM-23566|pubmed:23942237	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-10042802|imex:IM-23566-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001077390.1|refseq:NP_062679.2|dip:DIP-59198N|ensembl:ENSMUSG00000027466(gene)|ensembl:ENSMUST00000028964(transcript)|ensembl:ENSMUST00000109847(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051220"(cytoplasmic sequestering of protein)|go:"GO:0060546"(negative regulation of necroptotic process)|go:"GO:0071797"(LUBAC complex)|go:"GO:0097039"(protein linear polyubiquitination)|go:"GO:0140311"(protein sequestering activity)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|interpro:IPR000626(Ubiquitin)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR001876(Zinc finger, RanBP2-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR026261|interpro:IPR027370|interpro:IPR029071|interpro:IPR036443|interpro:IPR044066|rcsb pdb:3B08|rcsb pdb:3B0A|rcsb pdb:5Y3T|reactome:R-MMU-5357905|reactome:R-MMU-5357956|reactome:R-MMU-983168	refseq:NP_919327.2|dip:DIP-49579N|reactome:R-MMU-5357905|reactome:R-MMU-5357956|rcsb pdb:5Y3T|ensembl:ENSMUSG00000047098(gene)|ensembl:ENSMUST00000019443(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005829"(cytosol)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0023035"(CD40 signaling pathway)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0035631"(CD40 receptor complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0060546"(negative regulation of necroptotic process)|go:"GO:0071797"(LUBAC complex)|go:"GO:0097039"(protein linear polyubiquitination)|interpro:IPR001876(Zinc finger, RanBP2-type)|interpro:IPR002867(Zinc finger, C6HC-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR017907|interpro:IPR018997|interpro:IPR026254|interpro:IPR032065|interpro:IPR036339|interpro:IPR036443|interpro:IPR040641|interpro:IPR041031|interpro:IPR044066	-	-	-	figure legend:f1d|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/12/15	2015/02/09	rogid:BrdBce5XWr8fSk3w0rPsymbLpC410090	rogid:xIbE6XjFXsobrXWbjabTL3rhhf410090	intact-crc:853F7C49AF03A25C|rigid:eYdUMQ6/THKonpaAGllLUcMg7s8	false	-	binding-associated region:1-704	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9WUB0	uniprotkb:Q91WA6	intact:EBI-6141072|uniprotkb:A2ANR4|uniprotkb:Q3TM86|uniprotkb:Q8C2I0|ensembl:ENSMUSP00000028964|ensembl:ENSMUSP00000105473	intact:EBI-646097|uniprotkb:Q7TNT3|uniprotkb:Q8CHL3|ensembl:ENSMUSP00000023211	psi-mi:hoil1_mouse(display_long)|uniprotkb:Rbck1(gene name)|psi-mi:Rbck1(display_short)|uniprotkb:Rbck(gene name synonym)|uniprotkb:Ubce7ip3(gene name synonym)|uniprotkb:Uip28(gene name synonym)|uniprotkb:Heme-oxidized IRP2 ubiquitin ligase 1 homolog(gene name synonym)|uniprotkb:UbcM4-interacting protein 28(gene name synonym)|uniprotkb:Ubiquitin-conjugating enzyme 7-interacting protein 3(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase HOIL-1(gene name synonym)	psi-mi:shrpn_mouse(display_long)|uniprotkb:Shank-associated RH domain-interacting protein(gene name synonym)|uniprotkb:Shank-interacting protein-like 1(gene name synonym)|uniprotkb:Sharpin(gene name)|psi-mi:Sharpin(display_short)|uniprotkb:Sipl1(gene name synonym)|uniprotkb:Cpdm(gene name synonym)	psi-mi:"MI:0071"(molecular sieving)	Sasaki et al. (2013)	imex:IM-23566|pubmed:23942237	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-10042802|imex:IM-23566-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001077390.1|refseq:NP_062679.2|dip:DIP-59198N|ensembl:ENSMUSG00000027466(gene)|ensembl:ENSMUST00000028964(transcript)|ensembl:ENSMUST00000109847(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051220"(cytoplasmic sequestering of protein)|go:"GO:0060546"(negative regulation of necroptotic process)|go:"GO:0071797"(LUBAC complex)|go:"GO:0097039"(protein linear polyubiquitination)|go:"GO:0140311"(protein sequestering activity)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|interpro:IPR000626(Ubiquitin)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR001876(Zinc finger, RanBP2-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR026261|interpro:IPR027370|interpro:IPR029071|interpro:IPR036443|interpro:IPR044066|rcsb pdb:3B08|rcsb pdb:3B0A|rcsb pdb:5Y3T|reactome:R-MMU-5357905|reactome:R-MMU-5357956|reactome:R-MMU-983168	refseq:NP_079616.2|dip:DIP-49461N|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007420"(brain development)|go:"GO:0008544"(epidermis development)|go:"GO:0010803"(regulation of tumor necrosis factor-mediated signaling pathway)|go:"GO:0014069"(postsynaptic density)|go:"GO:0030262"(apoptotic nuclear changes)|go:"GO:0030425"(dendrite)|go:"GO:0031424"(keratinization)|go:"GO:0031593"(polyubiquitin modification-dependent protein binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0071797"(LUBAC complex)|go:"GO:0097039"(protein linear polyubiquitination)|go:"GO:2000348"(regulation of CD40 signaling pathway)|interpro:IPR001876(Zinc finger, RanBP2-type)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR026261|interpro:IPR029071|interpro:IPR031912|interpro:IPR036443|rcsb pdb:5Y3T|reactome:R-MMU-5357905|reactome:R-MMU-5357956|ensembl:ENSMUSG00000022552(gene)|ensembl:ENSMUST00000023211(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005829"(cytosol)	-	-	-	figure legend:f1d|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/12/15	2015/02/09	rogid:BrdBce5XWr8fSk3w0rPsymbLpC410090	rogid:X0S3ADbUc34U7NHcxNjatvqgE2010090	intact-crc:853F7C49AF03A25C|rigid:eYdUMQ6/THKonpaAGllLUcMg7s8	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)