#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:Q86UK0 uniprotkb:O95477 intact:EBI-9541582|uniprotkb:Q53QE2|uniprotkb:Q53S55|uniprotkb:Q8IZW6|uniprotkb:Q96JT3|uniprotkb:Q9Y4M5|ensembl:ENSP00000272895 intact:EBI-784112|uniprotkb:Q96S56|uniprotkb:Q96T85|uniprotkb:Q9NQV4|uniprotkb:Q9UN06|uniprotkb:Q9UN07|uniprotkb:Q9UN08|uniprotkb:Q9UN09|uniprotkb:Q5VX33|ensembl:ENSP00000363868 psi-mi:abcac_human(display_long)|uniprotkb:ABCA12(gene name)|psi-mi:ABCA12(display_short)|uniprotkb:ABC12(gene name synonym)|uniprotkb:ATP-binding cassette transporter 12(gene name synonym)|uniprotkb:ATP-binding cassette sub-family A member 12(gene name synonym) psi-mi:abca1_human(display_long)|uniprotkb:ATP-binding cassette transporter 1(gene name synonym)|uniprotkb:Cholesterol efflux regulatory protein(gene name synonym)|uniprotkb:ABCA1(gene name)|psi-mi:ABCA1(display_short)|uniprotkb:ABC1(gene name synonym)|uniprotkb:CERP(gene name synonym)|uniprotkb:ATP-binding cassette sub-family A member 1(gene name synonym) psi-mi:"MI:0663"(confocal microscopy) Fu et al. (2013) pubmed:23931754|imex:IM-22610 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0403"(colocalization) psi-mi:"MI:1332"(bhf-ucl) intact:EBI-9541618|imex:IM-22610-1 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_056472.2|refseq:NP_775099.2|ensembl:ENSG00000144452(gene)|ensembl:ENST00000272895(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0003336"(corneocyte desquamation)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005319"(lipid transporter activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006672"(ceramide metabolic process)|go:"GO:0006869"(lipid transport)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0010875"(positive regulation of cholesterol efflux)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019725"(cellular homeostasis)|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0031424"(keratinization)|go:"GO:0032379"(positive regulation of intracellular lipid transport)|go:"GO:0032940"(secretion by cell)|go:"GO:0033700"(phospholipid efflux)|go:"GO:0034040"(ATPase-coupled lipid transmembrane transporter activity)|go:"GO:0034191"(apolipoprotein A-I receptor binding)|go:"GO:0035627"(ceramide transport)|go:"GO:0042626"(ATPase-coupled transmembrane transporter activity)|go:"GO:0043129"(surfactant homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045055"(regulated exocytosis)|go:"GO:0045616"(regulation of keratinocyte differentiation)|go:"GO:0048286"(lung alveolus development)|go:"GO:0055088"(lipid homeostasis)|go:"GO:0061178"(regulation of insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0061436"(establishment of skin barrier)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0097209"(epidermal lamellar body)|go:"GO:0097234"(epidermal lamellar body membrane)|go:"GO:0140326"(ATPase-coupled intramembrane lipid transporter activity)|go:"GO:2000010"(positive regulation of protein localization to cell surface)|interpro:IPR003439(ABC transporter-like)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR017871|interpro:IPR026082|interpro:IPR027417|interpro:IPR030371|reactome:R-HSA-1369062|reactome:R-HSA-5682294 refseq:NP_005493.2|dip:DIP-29211N|ensembl:ENSG00000165029(gene)|ensembl:ENST00000374736(transcript)|go:"GO:0002790"(peptide secretion)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005319"(lipid transporter activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005548"(phospholipid transporter activity)|go:"GO:0005768"(endosome)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006497"(protein lipidation)|go:"GO:0006869"(lipid transport)|go:"GO:0006911"(phagocytosis, engulfment)|go:"GO:0007040"(lysosome organization)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007584"(response to nutrient)|go:"GO:0008035"(high-density lipoprotein particle binding)|go:"GO:0008203"(cholesterol metabolic process)|go:"GO:0008320"(protein transmembrane transporter activity)|go:"GO:0009306"(protein secretion)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010745"(negative regulation of macrophage derived foam cell differentiation)|go:"GO:0010875"(positive regulation of cholesterol efflux)|go:"GO:0010887"(negative regulation of cholesterol storage)|go:"GO:0015485"(cholesterol binding)|go:"GO:0016197"(endosomal transport)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0019905"(syntaxin binding)|go:"GO:0023061"(signal release)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0031210"(phosphatidylcholine binding)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032367"(intracellular cholesterol transport)|go:"GO:0032489"(regulation of Cdc42 protein signal transduction)|go:"GO:0033344"(cholesterol efflux)|go:"GO:0033700"(phospholipid efflux)|go:"GO:0034185"(apolipoprotein binding)|go:"GO:0034186"(apolipoprotein A-I binding)|go:"GO:0034188"(apolipoprotein A-I receptor activity)|go:"GO:0034380"(high-density lipoprotein particle assembly)|go:"GO:0034616"(response to laminar fluid shear stress)|go:"GO:0035690"|go:"GO:0042626"(ATPase-coupled transmembrane transporter activity)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043691"(reverse cholesterol transport)|go:"GO:0045121"(membrane raft)|go:"GO:0045332"(phospholipid translocation)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0046623"(sphingolipid floppase activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051117"(ATPase binding)|go:"GO:0055091"(phospholipid homeostasis)|go:"GO:0060155"(platelet dense granule organization)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0071397"(cellular response to cholesterol)|go:"GO:0071404"(cellular response to low-density lipoprotein particle stimulus)|go:"GO:0071806"(protein transmembrane transport)|go:"GO:0090107"(regulation of high-density lipoprotein particle assembly)|go:"GO:0090108"(positive regulation of high-density lipoprotein particle assembly)|go:"GO:0090554"(phosphatidylcholine floppase activity)|go:"GO:0090556"(phosphatidylserine floppase activity)|go:"GO:0097708"(intracellular vesicle)|go:"GO:0120020"(cholesterol transfer activity)|go:"GO:0140115"(export across plasma membrane)|go:"GO:0140328"(floppase activity)|interpro:IPR003439(ABC transporter-like)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR017871|interpro:IPR026082|interpro:IPR027417|interpro:IPR030365|mint:O95477|rcsb pdb:5XJY|reactome:R-HSA-1989781|reactome:R-HSA-5682113|reactome:R-HSA-8963896|reactome:R-HSA-9029569 go:"GO:0005886"(plasma membrane)|go:"GO:0005737"(cytoplasm) - - figure legend:Fig 4D-F|dataset:Affinomics - Interactions curated for the Affinomics consortium.|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells) - 2014/05/28 2014/10/16 rogid:HZsVBkhHniBgQCaQVvqwlOk18+89606 rogid:DtErjp3P9x9wQEBDIbWae+OkfRc9606 intact-crc:7DE95EF79DBC4853|rigid:xn5wJyvKUIQh+KMzTKWC0op6xjA false - green fluorescent protein tag:?-? - - psi-mi:"MI:0422"(immunostaining) psi-mi:"MI:0422"(immunostaining) uniprotkb:P55055 uniprotkb:Q86UK0 intact:EBI-745354|uniprotkb:Q12970|uniprotkb:Q5I0Y1|uniprotkb:A8K490|uniprotkb:B4DNM6|uniprotkb:E7EWA6|ensembl:ENSP00000253727|ensembl:ENSP00000471194|ensembl:ENSP00000499121 intact:EBI-9541582|uniprotkb:Q53QE2|uniprotkb:Q53S55|uniprotkb:Q8IZW6|uniprotkb:Q96JT3|uniprotkb:Q9Y4M5|ensembl:ENSP00000272895 psi-mi:nr1h2_human(display_long)|uniprotkb:Ubiquitously-expressed nuclear receptor(gene name synonym)|uniprotkb:Nuclear receptor NER(gene name synonym)|uniprotkb:Liver X receptor beta(gene name synonym)|uniprotkb:Nuclear receptor subfamily 1 group H member 2(gene name synonym)|uniprotkb:NR1H2(gene name)|psi-mi:NR1H2(display_short)|uniprotkb:LXRB(gene name synonym)|uniprotkb:NER(gene name synonym)|uniprotkb:UNR(gene name synonym) psi-mi:abcac_human(display_long)|uniprotkb:ABCA12(gene name)|psi-mi:ABCA12(display_short)|uniprotkb:ABC12(gene name synonym)|uniprotkb:ATP-binding cassette transporter 12(gene name synonym)|uniprotkb:ATP-binding cassette sub-family A member 12(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Fu et al. (2013) pubmed:23931754|imex:IM-22610 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1332"(bhf-ucl) intact:EBI-9541763|imex:IM-22610-4 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001243576.1|refseq:NP_009052.3|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046965"(retinoid X receptor binding)|go:"GO:0048384"(retinoic acid receptor signaling pathway)|go:"GO:0048550"(negative regulation of pinocytosis)|go:"GO:0051006"(positive regulation of lipoprotein lipase activity)|go:"GO:0051117"(ATPase binding)|go:"GO:0060336"(negative regulation of interferon-gamma-mediated signaling pathway)|go:"GO:0090108"(positive regulation of high-density lipoprotein particle assembly)|go:"GO:0090187"(positive regulation of pancreatic juice secretion)|go:"GO:0090340"(positive regulation of secretion of lysosomal enzymes)|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|go:"GO:1903573"(negative regulation of response to endoplasmic reticulum stress)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|interpro:IPR001628(Zinc finger, nuclear hormone receptor-type)|interpro:IPR001723(Steroid hormone receptor)|interpro:IPR013088(Zinc finger, NHR/GATA-type)|interpro:IPR023257|interpro:IPR035500|mint:P55055|rcsb pdb:1P8D|rcsb pdb:1PQ6|rcsb pdb:1PQ9|rcsb pdb:1PQC|rcsb pdb:1UPV|rcsb pdb:1UPW|rcsb pdb:3KFC|rcsb pdb:3L0E|rcsb pdb:4DK7|rcsb pdb:4DK8|rcsb pdb:4NQA|rcsb pdb:4RAK|rcsb pdb:5HJP|rcsb pdb:5I4V|rcsb pdb:5JY3|rcsb pdb:5KYA|interpro:IPR000536(Nuclear hormone receptor, ligand-binding, core)|rcsb pdb:5KYJ|rcsb pdb:6JIO|rcsb pdb:6K9G|rcsb pdb:6K9H|rcsb pdb:6S4N|rcsb pdb:6S4T|rcsb pdb:6S4U|rcsb pdb:6S5K|reactome:R-HSA-1989781|reactome:R-HSA-383280|reactome:R-HSA-4090294|reactome:R-HSA-8866427|reactome:R-HSA-9029558|reactome:R-HSA-9029569|reactome:R-HSA-9031525|reactome:R-HSA-9031528|reactome:R-HSA-9623433|rcsb pdb:6K9M|ensembl:ENSG00000131408(gene)|ensembl:ENST00000253727(transcript)|ensembl:ENST00000593926(transcript)|ensembl:ENST00000652203(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0004879"(nuclear receptor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010745"(negative regulation of macrophage derived foam cell differentiation)|go:"GO:0010867"(positive regulation of triglyceride biosynthetic process)|go:"GO:0010875"(positive regulation of cholesterol efflux)|go:"GO:0010884"(positive regulation of lipid storage)|go:"GO:0010887"(negative regulation of cholesterol storage)|go:"GO:0030154"(cell differentiation)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0032270"(positive regulation of cellular protein metabolic process)|go:"GO:0032369"(negative regulation of lipid transport)|go:"GO:0032376"(positive regulation of cholesterol transport)|go:"GO:0034191"(apolipoprotein A-I receptor binding)|go:"GO:0036151"(phosphatidylcholine acyl-chain remodeling)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0045723"(positive regulation of fatty acid biosynthetic process)|go:"GO:0045861"(negative regulation of proteolysis)|dip:DIP-53004N refseq:NP_056472.2|refseq:NP_775099.2|ensembl:ENSG00000144452(gene)|ensembl:ENST00000272895(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0003336"(corneocyte desquamation)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005319"(lipid transporter activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006672"(ceramide metabolic process)|go:"GO:0006869"(lipid transport)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0010875"(positive regulation of cholesterol efflux)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019725"(cellular homeostasis)|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0031424"(keratinization)|go:"GO:0032379"(positive regulation of intracellular lipid transport)|go:"GO:0032940"(secretion by cell)|go:"GO:0033700"(phospholipid efflux)|go:"GO:0034040"(ATPase-coupled lipid transmembrane transporter activity)|go:"GO:0034191"(apolipoprotein A-I receptor binding)|go:"GO:0035627"(ceramide transport)|go:"GO:0042626"(ATPase-coupled transmembrane transporter activity)|go:"GO:0043129"(surfactant homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045055"(regulated exocytosis)|go:"GO:0045616"(regulation of keratinocyte differentiation)|go:"GO:0048286"(lung alveolus development)|go:"GO:0055088"(lipid homeostasis)|go:"GO:0061178"(regulation of insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0061436"(establishment of skin barrier)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0097209"(epidermal lamellar body)|go:"GO:0097234"(epidermal lamellar body membrane)|go:"GO:0140326"(ATPase-coupled intramembrane lipid transporter activity)|go:"GO:2000010"(positive regulation of protein localization to cell surface)|interpro:IPR003439(ABC transporter-like)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR017871|interpro:IPR026082|interpro:IPR027417|interpro:IPR030371|reactome:R-HSA-1369062|reactome:R-HSA-5682294 go:"GO:0005886"(plasma membrane)|go:"GO:0005737"(cytoplasm) - - figure legend:Fig 4k|dataset:Affinomics - Interactions curated for the Affinomics consortium.|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells) - 2014/05/28 2014/10/16 rogid:fkzJzzYByUN5vk9G6GWcy8LDV249606 rogid:HZsVBkhHniBgQCaQVvqwlOk18+89606 intact-crc:822978DADC151170|rigid:lwLuIu+I3buLGief1Knje511wqA false - - - - psi-mi:"MI:0086"(polyclonal antibody western blot) psi-mi:"MI:0086"(polyclonal antibody western blot) uniprotkb:P55055 uniprotkb:O95477 intact:EBI-745354|uniprotkb:Q12970|uniprotkb:Q5I0Y1|uniprotkb:A8K490|uniprotkb:B4DNM6|uniprotkb:E7EWA6|ensembl:ENSP00000253727|ensembl:ENSP00000471194|ensembl:ENSP00000499121 intact:EBI-784112|uniprotkb:Q96S56|uniprotkb:Q96T85|uniprotkb:Q9NQV4|uniprotkb:Q9UN06|uniprotkb:Q9UN07|uniprotkb:Q9UN08|uniprotkb:Q9UN09|uniprotkb:Q5VX33|ensembl:ENSP00000363868 psi-mi:nr1h2_human(display_long)|uniprotkb:Ubiquitously-expressed nuclear receptor(gene name synonym)|uniprotkb:Nuclear receptor NER(gene name synonym)|uniprotkb:Liver X receptor beta(gene name synonym)|uniprotkb:Nuclear receptor subfamily 1 group H member 2(gene name synonym)|uniprotkb:NR1H2(gene name)|psi-mi:NR1H2(display_short)|uniprotkb:LXRB(gene name synonym)|uniprotkb:NER(gene name synonym)|uniprotkb:UNR(gene name synonym) psi-mi:abca1_human(display_long)|uniprotkb:ATP-binding cassette transporter 1(gene name synonym)|uniprotkb:Cholesterol efflux regulatory protein(gene name synonym)|uniprotkb:ABCA1(gene name)|psi-mi:ABCA1(display_short)|uniprotkb:ABC1(gene name synonym)|uniprotkb:CERP(gene name synonym)|uniprotkb:ATP-binding cassette sub-family A member 1(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Fu et al. (2013) pubmed:23931754|imex:IM-22610 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0914"(association) psi-mi:"MI:1332"(bhf-ucl) intact:EBI-9541763|imex:IM-22610-4 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001243576.1|refseq:NP_009052.3|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046965"(retinoid X receptor binding)|go:"GO:0048384"(retinoic acid receptor signaling pathway)|go:"GO:0048550"(negative regulation of pinocytosis)|go:"GO:0051006"(positive regulation of lipoprotein lipase activity)|go:"GO:0051117"(ATPase binding)|go:"GO:0060336"(negative regulation of interferon-gamma-mediated signaling pathway)|go:"GO:0090108"(positive regulation of high-density lipoprotein particle assembly)|go:"GO:0090187"(positive regulation of pancreatic juice secretion)|go:"GO:0090340"(positive regulation of secretion of lysosomal enzymes)|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|go:"GO:1903573"(negative regulation of response to endoplasmic reticulum stress)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|interpro:IPR001628(Zinc finger, nuclear hormone receptor-type)|interpro:IPR001723(Steroid hormone receptor)|interpro:IPR013088(Zinc finger, NHR/GATA-type)|interpro:IPR023257|interpro:IPR035500|mint:P55055|rcsb pdb:1P8D|rcsb pdb:1PQ6|rcsb pdb:1PQ9|rcsb pdb:1PQC|rcsb pdb:1UPV|rcsb pdb:1UPW|rcsb pdb:3KFC|rcsb pdb:3L0E|rcsb pdb:4DK7|rcsb pdb:4DK8|rcsb pdb:4NQA|rcsb pdb:4RAK|rcsb pdb:5HJP|rcsb pdb:5I4V|rcsb pdb:5JY3|rcsb pdb:5KYA|interpro:IPR000536(Nuclear hormone receptor, ligand-binding, core)|rcsb pdb:5KYJ|rcsb pdb:6JIO|rcsb pdb:6K9G|rcsb pdb:6K9H|rcsb pdb:6S4N|rcsb pdb:6S4T|rcsb pdb:6S4U|rcsb pdb:6S5K|reactome:R-HSA-1989781|reactome:R-HSA-383280|reactome:R-HSA-4090294|reactome:R-HSA-8866427|reactome:R-HSA-9029558|reactome:R-HSA-9029569|reactome:R-HSA-9031525|reactome:R-HSA-9031528|reactome:R-HSA-9623433|rcsb pdb:6K9M|ensembl:ENSG00000131408(gene)|ensembl:ENST00000253727(transcript)|ensembl:ENST00000593926(transcript)|ensembl:ENST00000652203(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0004879"(nuclear receptor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010745"(negative regulation of macrophage derived foam cell differentiation)|go:"GO:0010867"(positive regulation of triglyceride biosynthetic process)|go:"GO:0010875"(positive regulation of cholesterol efflux)|go:"GO:0010884"(positive regulation of lipid storage)|go:"GO:0010887"(negative regulation of cholesterol storage)|go:"GO:0030154"(cell differentiation)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0032270"(positive regulation of cellular protein metabolic process)|go:"GO:0032369"(negative regulation of lipid transport)|go:"GO:0032376"(positive regulation of cholesterol transport)|go:"GO:0034191"(apolipoprotein A-I receptor binding)|go:"GO:0036151"(phosphatidylcholine acyl-chain remodeling)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0045723"(positive regulation of fatty acid biosynthetic process)|go:"GO:0045861"(negative regulation of proteolysis)|dip:DIP-53004N refseq:NP_005493.2|dip:DIP-29211N|ensembl:ENSG00000165029(gene)|ensembl:ENST00000374736(transcript)|go:"GO:0002790"(peptide secretion)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005319"(lipid transporter activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005548"(phospholipid transporter activity)|go:"GO:0005768"(endosome)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006497"(protein lipidation)|go:"GO:0006869"(lipid transport)|go:"GO:0006911"(phagocytosis, engulfment)|go:"GO:0007040"(lysosome organization)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007584"(response to nutrient)|go:"GO:0008035"(high-density lipoprotein particle binding)|go:"GO:0008203"(cholesterol metabolic process)|go:"GO:0008320"(protein transmembrane transporter activity)|go:"GO:0009306"(protein secretion)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010745"(negative regulation of macrophage derived foam cell differentiation)|go:"GO:0010875"(positive regulation of cholesterol efflux)|go:"GO:0010887"(negative regulation of cholesterol storage)|go:"GO:0015485"(cholesterol binding)|go:"GO:0016197"(endosomal transport)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0019905"(syntaxin binding)|go:"GO:0023061"(signal release)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0031210"(phosphatidylcholine binding)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032367"(intracellular cholesterol transport)|go:"GO:0032489"(regulation of Cdc42 protein signal transduction)|go:"GO:0033344"(cholesterol efflux)|go:"GO:0033700"(phospholipid efflux)|go:"GO:0034185"(apolipoprotein binding)|go:"GO:0034186"(apolipoprotein A-I binding)|go:"GO:0034188"(apolipoprotein A-I receptor activity)|go:"GO:0034380"(high-density lipoprotein particle assembly)|go:"GO:0034616"(response to laminar fluid shear stress)|go:"GO:0035690"|go:"GO:0042626"(ATPase-coupled transmembrane transporter activity)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043691"(reverse cholesterol transport)|go:"GO:0045121"(membrane raft)|go:"GO:0045332"(phospholipid translocation)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0046623"(sphingolipid floppase activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051117"(ATPase binding)|go:"GO:0055091"(phospholipid homeostasis)|go:"GO:0060155"(platelet dense granule organization)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0071397"(cellular response to cholesterol)|go:"GO:0071404"(cellular response to low-density lipoprotein particle stimulus)|go:"GO:0071806"(protein transmembrane transport)|go:"GO:0090107"(regulation of high-density lipoprotein particle assembly)|go:"GO:0090108"(positive regulation of high-density lipoprotein particle assembly)|go:"GO:0090554"(phosphatidylcholine floppase activity)|go:"GO:0090556"(phosphatidylserine floppase activity)|go:"GO:0097708"(intracellular vesicle)|go:"GO:0120020"(cholesterol transfer activity)|go:"GO:0140115"(export across plasma membrane)|go:"GO:0140328"(floppase activity)|interpro:IPR003439(ABC transporter-like)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR017871|interpro:IPR026082|interpro:IPR027417|interpro:IPR030365|mint:O95477|rcsb pdb:5XJY|reactome:R-HSA-1989781|reactome:R-HSA-5682113|reactome:R-HSA-8963896|reactome:R-HSA-9029569 go:"GO:0005886"(plasma membrane)|go:"GO:0005737"(cytoplasm) - - figure legend:Fig 4k|dataset:Affinomics - Interactions curated for the Affinomics consortium.|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells) - 2014/05/28 2014/10/16 rogid:fkzJzzYByUN5vk9G6GWcy8LDV249606 rogid:DtErjp3P9x9wQEBDIbWae+OkfRc9606 intact-crc:822978DADC151170|rigid:lwLuIu+I3buLGief1Knje511wqA false - green fluorescent protein tag:?-? - - psi-mi:"MI:0086"(polyclonal antibody western blot) psi-mi:"MI:0086"(polyclonal antibody western blot) uniprotkb:O95477 uniprotkb:Q86UK0 intact:EBI-784112|uniprotkb:Q96S56|uniprotkb:Q96T85|uniprotkb:Q9NQV4|uniprotkb:Q9UN06|uniprotkb:Q9UN07|uniprotkb:Q9UN08|uniprotkb:Q9UN09|uniprotkb:Q5VX33|ensembl:ENSP00000363868 intact:EBI-9541582|uniprotkb:Q53QE2|uniprotkb:Q53S55|uniprotkb:Q8IZW6|uniprotkb:Q96JT3|uniprotkb:Q9Y4M5|ensembl:ENSP00000272895 psi-mi:abca1_human(display_long)|uniprotkb:ATP-binding cassette transporter 1(gene name synonym)|uniprotkb:Cholesterol efflux regulatory protein(gene name synonym)|uniprotkb:ABCA1(gene name)|psi-mi:ABCA1(display_short)|uniprotkb:ABC1(gene name synonym)|uniprotkb:CERP(gene name synonym)|uniprotkb:ATP-binding cassette sub-family A member 1(gene name synonym) psi-mi:abcac_human(display_long)|uniprotkb:ABCA12(gene name)|psi-mi:ABCA12(display_short)|uniprotkb:ABC12(gene name synonym)|uniprotkb:ATP-binding cassette transporter 12(gene name synonym)|uniprotkb:ATP-binding cassette sub-family A member 12(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Fu et al. (2013) pubmed:23931754|imex:IM-22610 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:1332"(bhf-ucl) intact:EBI-9541649|imex:IM-22610-2 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_005493.2|dip:DIP-29211N|ensembl:ENSG00000165029(gene)|ensembl:ENST00000374736(transcript)|go:"GO:0002790"(peptide secretion)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005319"(lipid transporter activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005548"(phospholipid transporter activity)|go:"GO:0005768"(endosome)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006497"(protein lipidation)|go:"GO:0006869"(lipid transport)|go:"GO:0006911"(phagocytosis, engulfment)|go:"GO:0007040"(lysosome organization)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007584"(response to nutrient)|go:"GO:0008035"(high-density lipoprotein particle binding)|go:"GO:0008203"(cholesterol metabolic process)|go:"GO:0008320"(protein transmembrane transporter activity)|go:"GO:0009306"(protein secretion)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010745"(negative regulation of macrophage derived foam cell differentiation)|go:"GO:0010875"(positive regulation of cholesterol efflux)|go:"GO:0010887"(negative regulation of cholesterol storage)|go:"GO:0015485"(cholesterol binding)|go:"GO:0016197"(endosomal transport)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0019905"(syntaxin binding)|go:"GO:0023061"(signal release)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0031210"(phosphatidylcholine binding)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032367"(intracellular cholesterol transport)|go:"GO:0032489"(regulation of Cdc42 protein signal transduction)|go:"GO:0033344"(cholesterol efflux)|go:"GO:0033700"(phospholipid efflux)|go:"GO:0034185"(apolipoprotein binding)|go:"GO:0034186"(apolipoprotein A-I binding)|go:"GO:0034188"(apolipoprotein A-I receptor activity)|go:"GO:0034380"(high-density lipoprotein particle assembly)|go:"GO:0034616"(response to laminar fluid shear stress)|go:"GO:0035690"|go:"GO:0042626"(ATPase-coupled transmembrane transporter activity)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043691"(reverse cholesterol transport)|go:"GO:0045121"(membrane raft)|go:"GO:0045332"(phospholipid translocation)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0046623"(sphingolipid floppase activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051117"(ATPase binding)|go:"GO:0055091"(phospholipid homeostasis)|go:"GO:0060155"(platelet dense granule organization)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0071397"(cellular response to cholesterol)|go:"GO:0071404"(cellular response to low-density lipoprotein particle stimulus)|go:"GO:0071806"(protein transmembrane transport)|go:"GO:0090107"(regulation of high-density lipoprotein particle assembly)|go:"GO:0090108"(positive regulation of high-density lipoprotein particle assembly)|go:"GO:0090554"(phosphatidylcholine floppase activity)|go:"GO:0090556"(phosphatidylserine floppase activity)|go:"GO:0097708"(intracellular vesicle)|go:"GO:0120020"(cholesterol transfer activity)|go:"GO:0140115"(export across plasma membrane)|go:"GO:0140328"(floppase activity)|interpro:IPR003439(ABC transporter-like)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR017871|interpro:IPR026082|interpro:IPR027417|interpro:IPR030365|mint:O95477|rcsb pdb:5XJY|reactome:R-HSA-1989781|reactome:R-HSA-5682113|reactome:R-HSA-8963896|reactome:R-HSA-9029569 refseq:NP_056472.2|refseq:NP_775099.2|ensembl:ENSG00000144452(gene)|ensembl:ENST00000272895(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0003336"(corneocyte desquamation)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005319"(lipid transporter activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006672"(ceramide metabolic process)|go:"GO:0006869"(lipid transport)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0010875"(positive regulation of cholesterol efflux)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019725"(cellular homeostasis)|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0031424"(keratinization)|go:"GO:0032379"(positive regulation of intracellular lipid transport)|go:"GO:0032940"(secretion by cell)|go:"GO:0033700"(phospholipid efflux)|go:"GO:0034040"(ATPase-coupled lipid transmembrane transporter activity)|go:"GO:0034191"(apolipoprotein A-I receptor binding)|go:"GO:0035627"(ceramide transport)|go:"GO:0042626"(ATPase-coupled transmembrane transporter activity)|go:"GO:0043129"(surfactant homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045055"(regulated exocytosis)|go:"GO:0045616"(regulation of keratinocyte differentiation)|go:"GO:0048286"(lung alveolus development)|go:"GO:0055088"(lipid homeostasis)|go:"GO:0061178"(regulation of insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0061436"(establishment of skin barrier)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0097209"(epidermal lamellar body)|go:"GO:0097234"(epidermal lamellar body membrane)|go:"GO:0140326"(ATPase-coupled intramembrane lipid transporter activity)|go:"GO:2000010"(positive regulation of protein localization to cell surface)|interpro:IPR003439(ABC transporter-like)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR017871|interpro:IPR026082|interpro:IPR027417|interpro:IPR030371|reactome:R-HSA-1369062|reactome:R-HSA-5682294 go:"GO:0005886"(plasma membrane)|go:"GO:0005737"(cytoplasm) - - figure legend:Fig 4i|dataset:Affinomics - Interactions curated for the Affinomics consortium.|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells) - 2014/05/28 2014/10/16 rogid:DtErjp3P9x9wQEBDIbWae+OkfRc9606 rogid:HZsVBkhHniBgQCaQVvqwlOk18+89606 intact-crc:129CA45DF765B43F|rigid:xn5wJyvKUIQh+KMzTKWC0op6xjA false green fluorescent protein tag:?-? - - - psi-mi:"MI:0086"(polyclonal antibody western blot) psi-mi:"MI:0086"(polyclonal antibody western blot) uniprotkb:P55055 uniprotkb:O95477 intact:EBI-745354|uniprotkb:Q12970|uniprotkb:Q5I0Y1|uniprotkb:A8K490|uniprotkb:B4DNM6|uniprotkb:E7EWA6|ensembl:ENSP00000253727|ensembl:ENSP00000471194|ensembl:ENSP00000499121 intact:EBI-784112|uniprotkb:Q96S56|uniprotkb:Q96T85|uniprotkb:Q9NQV4|uniprotkb:Q9UN06|uniprotkb:Q9UN07|uniprotkb:Q9UN08|uniprotkb:Q9UN09|uniprotkb:Q5VX33|ensembl:ENSP00000363868 psi-mi:nr1h2_human(display_long)|uniprotkb:Ubiquitously-expressed nuclear receptor(gene name synonym)|uniprotkb:Nuclear receptor NER(gene name synonym)|uniprotkb:Liver X receptor beta(gene name synonym)|uniprotkb:Nuclear receptor subfamily 1 group H member 2(gene name synonym)|uniprotkb:NR1H2(gene name)|psi-mi:NR1H2(display_short)|uniprotkb:LXRB(gene name synonym)|uniprotkb:NER(gene name synonym)|uniprotkb:UNR(gene name synonym) psi-mi:abca1_human(display_long)|uniprotkb:ATP-binding cassette transporter 1(gene name synonym)|uniprotkb:Cholesterol efflux regulatory protein(gene name synonym)|uniprotkb:ABCA1(gene name)|psi-mi:ABCA1(display_short)|uniprotkb:ABC1(gene name synonym)|uniprotkb:CERP(gene name synonym)|uniprotkb:ATP-binding cassette sub-family A member 1(gene name synonym) psi-mi:"MI:0813"(proximity ligation assay) Fu et al. (2013) pubmed:23931754|imex:IM-22610 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:1332"(bhf-ucl) intact:EBI-9541806|imex:IM-22610-6 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001243576.1|refseq:NP_009052.3|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046965"(retinoid X receptor binding)|go:"GO:0048384"(retinoic acid receptor signaling pathway)|go:"GO:0048550"(negative regulation of pinocytosis)|go:"GO:0051006"(positive regulation of lipoprotein lipase activity)|go:"GO:0051117"(ATPase binding)|go:"GO:0060336"(negative regulation of interferon-gamma-mediated signaling pathway)|go:"GO:0090108"(positive regulation of high-density lipoprotein particle assembly)|go:"GO:0090187"(positive regulation of pancreatic juice secretion)|go:"GO:0090340"(positive regulation of secretion of lysosomal enzymes)|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|go:"GO:1903573"(negative regulation of response to endoplasmic reticulum stress)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|interpro:IPR001628(Zinc finger, nuclear hormone receptor-type)|interpro:IPR001723(Steroid hormone receptor)|interpro:IPR013088(Zinc finger, NHR/GATA-type)|interpro:IPR023257|interpro:IPR035500|mint:P55055|rcsb pdb:1P8D|rcsb pdb:1PQ6|rcsb pdb:1PQ9|rcsb pdb:1PQC|rcsb pdb:1UPV|rcsb pdb:1UPW|rcsb pdb:3KFC|rcsb pdb:3L0E|rcsb pdb:4DK7|rcsb pdb:4DK8|rcsb pdb:4NQA|rcsb pdb:4RAK|rcsb pdb:5HJP|rcsb pdb:5I4V|rcsb pdb:5JY3|rcsb pdb:5KYA|interpro:IPR000536(Nuclear hormone receptor, ligand-binding, core)|rcsb pdb:5KYJ|rcsb pdb:6JIO|rcsb pdb:6K9G|rcsb pdb:6K9H|rcsb pdb:6S4N|rcsb pdb:6S4T|rcsb pdb:6S4U|rcsb pdb:6S5K|reactome:R-HSA-1989781|reactome:R-HSA-383280|reactome:R-HSA-4090294|reactome:R-HSA-8866427|reactome:R-HSA-9029558|reactome:R-HSA-9029569|reactome:R-HSA-9031525|reactome:R-HSA-9031528|reactome:R-HSA-9623433|rcsb pdb:6K9M|ensembl:ENSG00000131408(gene)|ensembl:ENST00000253727(transcript)|ensembl:ENST00000593926(transcript)|ensembl:ENST00000652203(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0004879"(nuclear receptor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010745"(negative regulation of macrophage derived foam cell differentiation)|go:"GO:0010867"(positive regulation of triglyceride biosynthetic process)|go:"GO:0010875"(positive regulation of cholesterol efflux)|go:"GO:0010884"(positive regulation of lipid storage)|go:"GO:0010887"(negative regulation of cholesterol storage)|go:"GO:0030154"(cell differentiation)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0032270"(positive regulation of cellular protein metabolic process)|go:"GO:0032369"(negative regulation of lipid transport)|go:"GO:0032376"(positive regulation of cholesterol transport)|go:"GO:0034191"(apolipoprotein A-I receptor binding)|go:"GO:0036151"(phosphatidylcholine acyl-chain remodeling)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0045723"(positive regulation of fatty acid biosynthetic process)|go:"GO:0045861"(negative regulation of proteolysis)|dip:DIP-53004N refseq:NP_005493.2|dip:DIP-29211N|ensembl:ENSG00000165029(gene)|ensembl:ENST00000374736(transcript)|go:"GO:0002790"(peptide secretion)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005319"(lipid transporter activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005548"(phospholipid transporter activity)|go:"GO:0005768"(endosome)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006497"(protein lipidation)|go:"GO:0006869"(lipid transport)|go:"GO:0006911"(phagocytosis, engulfment)|go:"GO:0007040"(lysosome organization)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007584"(response to nutrient)|go:"GO:0008035"(high-density lipoprotein particle binding)|go:"GO:0008203"(cholesterol metabolic process)|go:"GO:0008320"(protein transmembrane transporter activity)|go:"GO:0009306"(protein secretion)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010745"(negative regulation of macrophage derived foam cell differentiation)|go:"GO:0010875"(positive regulation of cholesterol efflux)|go:"GO:0010887"(negative regulation of cholesterol storage)|go:"GO:0015485"(cholesterol binding)|go:"GO:0016197"(endosomal transport)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0019905"(syntaxin binding)|go:"GO:0023061"(signal release)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0031210"(phosphatidylcholine binding)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032367"(intracellular cholesterol transport)|go:"GO:0032489"(regulation of Cdc42 protein signal transduction)|go:"GO:0033344"(cholesterol efflux)|go:"GO:0033700"(phospholipid efflux)|go:"GO:0034185"(apolipoprotein binding)|go:"GO:0034186"(apolipoprotein A-I binding)|go:"GO:0034188"(apolipoprotein A-I receptor activity)|go:"GO:0034380"(high-density lipoprotein particle assembly)|go:"GO:0034616"(response to laminar fluid shear stress)|go:"GO:0035690"|go:"GO:0042626"(ATPase-coupled transmembrane transporter activity)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043691"(reverse cholesterol transport)|go:"GO:0045121"(membrane raft)|go:"GO:0045332"(phospholipid translocation)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0046623"(sphingolipid floppase activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051117"(ATPase binding)|go:"GO:0055091"(phospholipid homeostasis)|go:"GO:0060155"(platelet dense granule organization)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0071397"(cellular response to cholesterol)|go:"GO:0071404"(cellular response to low-density lipoprotein particle stimulus)|go:"GO:0071806"(protein transmembrane transport)|go:"GO:0090107"(regulation of high-density lipoprotein particle assembly)|go:"GO:0090108"(positive regulation of high-density lipoprotein particle assembly)|go:"GO:0090554"(phosphatidylcholine floppase activity)|go:"GO:0090556"(phosphatidylserine floppase activity)|go:"GO:0097708"(intracellular vesicle)|go:"GO:0120020"(cholesterol transfer activity)|go:"GO:0140115"(export across plasma membrane)|go:"GO:0140328"(floppase activity)|interpro:IPR003439(ABC transporter-like)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR017871|interpro:IPR026082|interpro:IPR027417|interpro:IPR030365|mint:O95477|rcsb pdb:5XJY|reactome:R-HSA-1989781|reactome:R-HSA-5682113|reactome:R-HSA-8963896|reactome:R-HSA-9029569 go:"GO:0005886"(plasma membrane)|go:"GO:0005737"(cytoplasm) - - figure legend:Fig 4M|dataset:Affinomics - Interactions curated for the Affinomics consortium.|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells) - 2014/05/28 2014/10/16 rogid:fkzJzzYByUN5vk9G6GWcy8LDV249606 rogid:DtErjp3P9x9wQEBDIbWae+OkfRc9606 intact-crc:9A135BC6AEA148D6|rigid:pIwzZID6E8fg7M8Az6S8Qzz4zhI false - green fluorescent protein tag:?-? - - psi-mi:"MI:0421"(identification by antibody) psi-mi:"MI:0421"(identification by antibody) uniprotkb:O95477 uniprotkb:Q86UK0 intact:EBI-784112|uniprotkb:Q96S56|uniprotkb:Q96T85|uniprotkb:Q9NQV4|uniprotkb:Q9UN06|uniprotkb:Q9UN07|uniprotkb:Q9UN08|uniprotkb:Q9UN09|uniprotkb:Q5VX33|ensembl:ENSP00000363868 intact:EBI-9541582|uniprotkb:Q53QE2|uniprotkb:Q53S55|uniprotkb:Q8IZW6|uniprotkb:Q96JT3|uniprotkb:Q9Y4M5|ensembl:ENSP00000272895 psi-mi:abca1_human(display_long)|uniprotkb:ATP-binding cassette transporter 1(gene name synonym)|uniprotkb:Cholesterol efflux regulatory protein(gene name synonym)|uniprotkb:ABCA1(gene name)|psi-mi:ABCA1(display_short)|uniprotkb:ABC1(gene name synonym)|uniprotkb:CERP(gene name synonym)|uniprotkb:ATP-binding cassette sub-family A member 1(gene name synonym) psi-mi:abcac_human(display_long)|uniprotkb:ABCA12(gene name)|psi-mi:ABCA12(display_short)|uniprotkb:ABC12(gene name synonym)|uniprotkb:ATP-binding cassette transporter 12(gene name synonym)|uniprotkb:ATP-binding cassette sub-family A member 12(gene name synonym) psi-mi:"MI:0813"(proximity ligation assay) Fu et al. (2013) pubmed:23931754|imex:IM-22610 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:2364"(proximity) psi-mi:"MI:1332"(bhf-ucl) intact:EBI-9541792|imex:IM-22610-5 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_005493.2|dip:DIP-29211N|ensembl:ENSG00000165029(gene)|ensembl:ENST00000374736(transcript)|go:"GO:0002790"(peptide secretion)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005319"(lipid transporter activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005548"(phospholipid transporter activity)|go:"GO:0005768"(endosome)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006497"(protein lipidation)|go:"GO:0006869"(lipid transport)|go:"GO:0006911"(phagocytosis, engulfment)|go:"GO:0007040"(lysosome organization)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007584"(response to nutrient)|go:"GO:0008035"(high-density lipoprotein particle binding)|go:"GO:0008203"(cholesterol metabolic process)|go:"GO:0008320"(protein transmembrane transporter activity)|go:"GO:0009306"(protein secretion)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010745"(negative regulation of macrophage derived foam cell differentiation)|go:"GO:0010875"(positive regulation of cholesterol efflux)|go:"GO:0010887"(negative regulation of cholesterol storage)|go:"GO:0015485"(cholesterol binding)|go:"GO:0016197"(endosomal transport)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0019905"(syntaxin binding)|go:"GO:0023061"(signal release)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0031210"(phosphatidylcholine binding)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032367"(intracellular cholesterol transport)|go:"GO:0032489"(regulation of Cdc42 protein signal transduction)|go:"GO:0033344"(cholesterol efflux)|go:"GO:0033700"(phospholipid efflux)|go:"GO:0034185"(apolipoprotein binding)|go:"GO:0034186"(apolipoprotein A-I binding)|go:"GO:0034188"(apolipoprotein A-I receptor activity)|go:"GO:0034380"(high-density lipoprotein particle assembly)|go:"GO:0034616"(response to laminar fluid shear stress)|go:"GO:0035690"|go:"GO:0042626"(ATPase-coupled transmembrane transporter activity)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043691"(reverse cholesterol transport)|go:"GO:0045121"(membrane raft)|go:"GO:0045332"(phospholipid translocation)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0046623"(sphingolipid floppase activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051117"(ATPase binding)|go:"GO:0055091"(phospholipid homeostasis)|go:"GO:0060155"(platelet dense granule organization)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0071397"(cellular response to cholesterol)|go:"GO:0071404"(cellular response to low-density lipoprotein particle stimulus)|go:"GO:0071806"(protein transmembrane transport)|go:"GO:0090107"(regulation of high-density lipoprotein particle assembly)|go:"GO:0090108"(positive regulation of high-density lipoprotein particle assembly)|go:"GO:0090554"(phosphatidylcholine floppase activity)|go:"GO:0090556"(phosphatidylserine floppase activity)|go:"GO:0097708"(intracellular vesicle)|go:"GO:0120020"(cholesterol transfer activity)|go:"GO:0140115"(export across plasma membrane)|go:"GO:0140328"(floppase activity)|interpro:IPR003439(ABC transporter-like)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR017871|interpro:IPR026082|interpro:IPR027417|interpro:IPR030365|mint:O95477|rcsb pdb:5XJY|reactome:R-HSA-1989781|reactome:R-HSA-5682113|reactome:R-HSA-8963896|reactome:R-HSA-9029569 refseq:NP_056472.2|refseq:NP_775099.2|ensembl:ENSG00000144452(gene)|ensembl:ENST00000272895(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0003336"(corneocyte desquamation)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005319"(lipid transporter activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006672"(ceramide metabolic process)|go:"GO:0006869"(lipid transport)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0010875"(positive regulation of cholesterol efflux)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019725"(cellular homeostasis)|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0031424"(keratinization)|go:"GO:0032379"(positive regulation of intracellular lipid transport)|go:"GO:0032940"(secretion by cell)|go:"GO:0033700"(phospholipid efflux)|go:"GO:0034040"(ATPase-coupled lipid transmembrane transporter activity)|go:"GO:0034191"(apolipoprotein A-I receptor binding)|go:"GO:0035627"(ceramide transport)|go:"GO:0042626"(ATPase-coupled transmembrane transporter activity)|go:"GO:0043129"(surfactant homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045055"(regulated exocytosis)|go:"GO:0045616"(regulation of keratinocyte differentiation)|go:"GO:0048286"(lung alveolus development)|go:"GO:0055088"(lipid homeostasis)|go:"GO:0061178"(regulation of insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0061436"(establishment of skin barrier)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0097209"(epidermal lamellar body)|go:"GO:0097234"(epidermal lamellar body membrane)|go:"GO:0140326"(ATPase-coupled intramembrane lipid transporter activity)|go:"GO:2000010"(positive regulation of protein localization to cell surface)|interpro:IPR003439(ABC transporter-like)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR017871|interpro:IPR026082|interpro:IPR027417|interpro:IPR030371|reactome:R-HSA-1369062|reactome:R-HSA-5682294 go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane) - - figure legend:Fig 4L|dataset:Affinomics - Interactions curated for the Affinomics consortium.|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells) - 2014/05/28 2014/10/16 rogid:DtErjp3P9x9wQEBDIbWae+OkfRc9606 rogid:HZsVBkhHniBgQCaQVvqwlOk18+89606 intact-crc:468BF4082F127355|rigid:xn5wJyvKUIQh+KMzTKWC0op6xjA false green fluorescent protein tag:?-? - - - psi-mi:"MI:0421"(identification by antibody) psi-mi:"MI:0421"(identification by antibody) uniprotkb:P41233 uniprotkb:Q60644 intact:EBI-9542881|uniprotkb:B1AWZ8|ensembl:ENSMUSP00000030010 intact:EBI-5276809|ensembl:ENSMUSP00000073188|ensembl:ENSMUSP00000103545|ensembl:ENSMUSP00000126788 psi-mi:abca1_mouse(display_long)|uniprotkb:ATP-binding cassette sub-family A member 1(gene name synonym)|uniprotkb:Abca1(gene name)|psi-mi:Abca1(display_short)|uniprotkb:Abc1(gene name synonym)|uniprotkb:ATP-binding cassette transporter 1(gene name synonym) psi-mi:nr1h2_mouse(display_long)|uniprotkb:Nr1h2(gene name)|psi-mi:Nr1h2(display_short)|uniprotkb:Lxrb(gene name synonym)|uniprotkb:Rip15(gene name synonym)|uniprotkb:Unr(gene name synonym)|uniprotkb:Unr2(gene name synonym)|uniprotkb:Liver X receptor beta(gene name synonym)|uniprotkb:Nuclear receptor subfamily 1 group H member 2(gene name synonym)|uniprotkb:Retinoid X receptor-interacting protein No.15(gene name synonym)|uniprotkb:Ubiquitously-expressed nuclear receptor(gene name synonym) psi-mi:"MI:0813"(proximity ligation assay) Fu et al. (2013) pubmed:23931754|imex:IM-22610 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:2364"(proximity) psi-mi:"MI:1332"(bhf-ucl) intact:EBI-9542856|imex:IM-22610-7 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_038482.3|ensembl:ENSMUSG00000015243(gene)|ensembl:ENSMUST00000030010(transcript)|go:"GO:0002790"(peptide secretion)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005319"(lipid transporter activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005548"(phospholipid transporter activity)|go:"GO:0005768"(endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006497"(protein lipidation)|go:"GO:0006869"(lipid transport)|go:"GO:0006911"(phagocytosis, engulfment)|go:"GO:0007040"(lysosome organization)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007584"(response to nutrient)|go:"GO:0008035"(high-density lipoprotein particle binding)|go:"GO:0008203"(cholesterol metabolic process)|go:"GO:0008320"(protein transmembrane transporter activity)|go:"GO:0009306"(protein secretion)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010875"(positive regulation of cholesterol efflux)|go:"GO:0015914"(phospholipid transport)|go:"GO:0016020"(membrane)|go:"GO:0016197"(endosomal transport)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0019905"(syntaxin binding)|go:"GO:0023061"(signal release)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0030301"(cholesterol transport)|go:"GO:0031210"(phosphatidylcholine binding)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032367"(intracellular cholesterol transport)|go:"GO:0032489"(regulation of Cdc42 protein signal transduction)|go:"GO:0033344"(cholesterol efflux)|go:"GO:0033700"(phospholipid efflux)|go:"GO:0034185"(apolipoprotein binding)|go:"GO:0034186"(apolipoprotein A-I binding)|go:"GO:0034188"(apolipoprotein A-I receptor activity)|go:"GO:0034380"(high-density lipoprotein particle assembly)|go:"GO:0034616"(response to laminar fluid shear stress)|go:"GO:0035690"|go:"GO:0042157"(lipoprotein metabolic process)|go:"GO:0042158"(lipoprotein biosynthetic process)|go:"GO:0042626"(ATPase-coupled transmembrane transporter activity)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043691"(reverse cholesterol transport)|go:"GO:0045121"(membrane raft)|go:"GO:0045332"(phospholipid translocation)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0046623"(sphingolipid floppase activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051117"(ATPase binding)|go:"GO:0055091"(phospholipid homeostasis)|go:"GO:0060155"(platelet dense granule organization)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0071397"(cellular response to cholesterol)|go:"GO:0071806"(protein transmembrane transport)|go:"GO:0090108"(positive regulation of high-density lipoprotein particle assembly)|go:"GO:0090554"(phosphatidylcholine floppase activity)|go:"GO:0090556"(phosphatidylserine floppase activity)|go:"GO:0097708"(intracellular vesicle)|go:"GO:0120020"(cholesterol transfer activity)|go:"GO:0140115"(export across plasma membrane)|go:"GO:0140328"(floppase activity)|interpro:IPR003439(ABC transporter-like)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR017871|interpro:IPR026082|interpro:IPR027417|interpro:IPR030365|reactome:R-MMU-8963896|reactome:R-MMU-9029569 refseq:NP_001272446.1|refseq:NP_001272447.1|refseq:NP_001272448.1|refseq:NP_033499.1|refseq:XP_006540867.1|dip:DIP-444N|ensembl:ENSMUSG00000060601(gene)|ensembl:ENSMUST00000073488(transcript)|ensembl:ENSMUST00000107912(transcript)|ensembl:ENSMUST00000167197(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0004879"(nuclear receptor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010867"(positive regulation of triglyceride biosynthetic process)|go:"GO:0010875"(positive regulation of cholesterol efflux)|go:"GO:0010887"(negative regulation of cholesterol storage)|go:"GO:0030154"(cell differentiation)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0032270"(positive regulation of cellular protein metabolic process)|go:"GO:0032369"(negative regulation of lipid transport)|go:"GO:0032376"(positive regulation of cholesterol transport)|go:"GO:0034191"(apolipoprotein A-I receptor binding)|go:"GO:0036151"(phosphatidylcholine acyl-chain remodeling)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0044255"(cellular lipid metabolic process)|go:"GO:0045723"(positive regulation of fatty acid biosynthetic process)|go:"GO:0045861"(negative regulation of proteolysis)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0010884"(positive regulation of lipid storage)|go:"GO:0046965"(retinoid X receptor binding)|reactome:R-MMU-8866427|reactome:R-MMU-9029569|reactome:R-MMU-9623433|go:"GO:0048384"(retinoic acid receptor signaling pathway)|go:"GO:0048550"(negative regulation of pinocytosis)|go:"GO:0051006"(positive regulation of lipoprotein lipase activity)|go:"GO:0051117"(ATPase binding)|go:"GO:0055088"(lipid homeostasis)|go:"GO:0090108"(positive regulation of high-density lipoprotein particle assembly)|go:"GO:0090187"(positive regulation of pancreatic juice secretion)|go:"GO:0090340"(positive regulation of secretion of lysosomal enzymes)|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|go:"GO:1903573"(negative regulation of response to endoplasmic reticulum stress)|interpro:IPR000536(Nuclear hormone receptor, ligand-binding, core)|interpro:IPR001628(Zinc finger, nuclear hormone receptor-type)|interpro:IPR001723(Steroid hormone receptor)|interpro:IPR013088(Zinc finger, NHR/GATA-type)|interpro:IPR023257|interpro:IPR035500|reactome:R-MMU-383280|reactome:R-MMU-4090294 go:"GO:0005886"(plasma membrane)|go:"GO:0005737"(cytoplasm) - - figure legend:Fig 3P|dataset:Affinomics - Interactions curated for the Affinomics consortium.|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-raw264_7)|taxid:10090(Mus musculus monocyte macrophage cell line RAW264) - 2014/05/28 2014/10/16 rogid:+HKK3frTwFQ0YBcm7vEalr0VPt810090 rogid:XSR7ZWDbMQj6uwWVWI++0pr0Eq810090 intact-crc:2568158FF38673A1|rigid:KtZ+VX6+KQpbH33aryZ82/HkeyM false - - - - psi-mi:"MI:0421"(identification by antibody) psi-mi:"MI:0421"(identification by antibody) uniprotkb:P41233 uniprotkb:B2RY21 intact:EBI-9542881|uniprotkb:B1AWZ8|ensembl:ENSMUSP00000030010 intact:EBI-9542771 psi-mi:abca1_mouse(display_long)|uniprotkb:ATP-binding cassette sub-family A member 1(gene name synonym)|uniprotkb:Abca1(gene name)|psi-mi:Abca1(display_short)|uniprotkb:Abc1(gene name synonym)|uniprotkb:ATP-binding cassette transporter 1(gene name synonym) psi-mi:b2ry21_mouse(display_long)|uniprotkb:Abca12(gene name)|psi-mi:Abca12(display_short) psi-mi:"MI:0813"(proximity ligation assay) Fu et al. (2013) pubmed:23931754|imex:IM-22610 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:2364"(proximity) psi-mi:"MI:1332"(bhf-ucl) intact:EBI-9542860|imex:IM-22610-8 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_038482.3|ensembl:ENSMUSG00000015243(gene)|ensembl:ENSMUST00000030010(transcript)|go:"GO:0002790"(peptide secretion)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005319"(lipid transporter activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005548"(phospholipid transporter activity)|go:"GO:0005768"(endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006497"(protein lipidation)|go:"GO:0006869"(lipid transport)|go:"GO:0006911"(phagocytosis, engulfment)|go:"GO:0007040"(lysosome organization)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007584"(response to nutrient)|go:"GO:0008035"(high-density lipoprotein particle binding)|go:"GO:0008203"(cholesterol metabolic process)|go:"GO:0008320"(protein transmembrane transporter activity)|go:"GO:0009306"(protein secretion)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010875"(positive regulation of cholesterol efflux)|go:"GO:0015914"(phospholipid transport)|go:"GO:0016020"(membrane)|go:"GO:0016197"(endosomal transport)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0019905"(syntaxin binding)|go:"GO:0023061"(signal release)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0030301"(cholesterol transport)|go:"GO:0031210"(phosphatidylcholine binding)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032367"(intracellular cholesterol transport)|go:"GO:0032489"(regulation of Cdc42 protein signal transduction)|go:"GO:0033344"(cholesterol efflux)|go:"GO:0033700"(phospholipid efflux)|go:"GO:0034185"(apolipoprotein binding)|go:"GO:0034186"(apolipoprotein A-I binding)|go:"GO:0034188"(apolipoprotein A-I receptor activity)|go:"GO:0034380"(high-density lipoprotein particle assembly)|go:"GO:0034616"(response to laminar fluid shear stress)|go:"GO:0035690"|go:"GO:0042157"(lipoprotein metabolic process)|go:"GO:0042158"(lipoprotein biosynthetic process)|go:"GO:0042626"(ATPase-coupled transmembrane transporter activity)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043691"(reverse cholesterol transport)|go:"GO:0045121"(membrane raft)|go:"GO:0045332"(phospholipid translocation)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0046623"(sphingolipid floppase activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051117"(ATPase binding)|go:"GO:0055091"(phospholipid homeostasis)|go:"GO:0060155"(platelet dense granule organization)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0071397"(cellular response to cholesterol)|go:"GO:0071806"(protein transmembrane transport)|go:"GO:0090108"(positive regulation of high-density lipoprotein particle assembly)|go:"GO:0090554"(phosphatidylcholine floppase activity)|go:"GO:0090556"(phosphatidylserine floppase activity)|go:"GO:0097708"(intracellular vesicle)|go:"GO:0120020"(cholesterol transfer activity)|go:"GO:0140115"(export across plasma membrane)|go:"GO:0140328"(floppase activity)|interpro:IPR003439(ABC transporter-like)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR017871|interpro:IPR026082|interpro:IPR027417|interpro:IPR030365|reactome:R-MMU-8963896|reactome:R-MMU-9029569 interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR026082|interpro:IPR030371|interpro:IPR003439(ABC transporter-like)|interpro:IPR017871|interpro:IPR027417|go:"GO:0005524"(ATP binding)|go:"GO:0006869"(lipid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0042626"(ATPase-coupled transmembrane transporter activity)|go:"GO:1903064"(positive regulation of reverse cholesterol transport) go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane) - - figure legend:Fig 3O|dataset:Affinomics - Interactions curated for the Affinomics consortium.|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-raw264_7)|taxid:10090(Mus musculus monocyte macrophage cell line RAW264) - 2014/05/28 2014/10/16 rogid:+HKK3frTwFQ0YBcm7vEalr0VPt810090 rogid:SK5MJMA4MtSSwgtFLqdB0XS1rAs10090 intact-crc:5855071D9CFF2591|rigid:4r9avWAqGoCHD8G6/91W5nntTa4 false - green fluorescent protein tag:?-? - - psi-mi:"MI:0421"(identification by antibody) psi-mi:"MI:0421"(identification by antibody) uniprotkb:Q60644 uniprotkb:B2RY21 intact:EBI-5276809|ensembl:ENSMUSP00000073188|ensembl:ENSMUSP00000103545|ensembl:ENSMUSP00000126788 intact:EBI-9542771 psi-mi:nr1h2_mouse(display_long)|uniprotkb:Nr1h2(gene name)|psi-mi:Nr1h2(display_short)|uniprotkb:Lxrb(gene name synonym)|uniprotkb:Rip15(gene name synonym)|uniprotkb:Unr(gene name synonym)|uniprotkb:Unr2(gene name synonym)|uniprotkb:Liver X receptor beta(gene name synonym)|uniprotkb:Nuclear receptor subfamily 1 group H member 2(gene name synonym)|uniprotkb:Retinoid X receptor-interacting protein No.15(gene name synonym)|uniprotkb:Ubiquitously-expressed nuclear receptor(gene name synonym) psi-mi:b2ry21_mouse(display_long)|uniprotkb:Abca12(gene name)|psi-mi:Abca12(display_short) psi-mi:"MI:0813"(proximity ligation assay) Fu et al. (2013) pubmed:23931754|imex:IM-22610 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:2364"(proximity) psi-mi:"MI:1332"(bhf-ucl) intact:EBI-9542939|imex:IM-22610-9 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001272446.1|refseq:NP_001272447.1|refseq:NP_001272448.1|refseq:NP_033499.1|refseq:XP_006540867.1|dip:DIP-444N|ensembl:ENSMUSG00000060601(gene)|ensembl:ENSMUST00000073488(transcript)|ensembl:ENSMUST00000107912(transcript)|ensembl:ENSMUST00000167197(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0004879"(nuclear receptor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010867"(positive regulation of triglyceride biosynthetic process)|go:"GO:0010875"(positive regulation of cholesterol efflux)|go:"GO:0010887"(negative regulation of cholesterol storage)|go:"GO:0030154"(cell differentiation)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0032270"(positive regulation of cellular protein metabolic process)|go:"GO:0032369"(negative regulation of lipid transport)|go:"GO:0032376"(positive regulation of cholesterol transport)|go:"GO:0034191"(apolipoprotein A-I receptor binding)|go:"GO:0036151"(phosphatidylcholine acyl-chain remodeling)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0044255"(cellular lipid metabolic process)|go:"GO:0045723"(positive regulation of fatty acid biosynthetic process)|go:"GO:0045861"(negative regulation of proteolysis)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0010884"(positive regulation of lipid storage)|go:"GO:0046965"(retinoid X receptor binding)|reactome:R-MMU-8866427|reactome:R-MMU-9029569|reactome:R-MMU-9623433|go:"GO:0048384"(retinoic acid receptor signaling pathway)|go:"GO:0048550"(negative regulation of pinocytosis)|go:"GO:0051006"(positive regulation of lipoprotein lipase activity)|go:"GO:0051117"(ATPase binding)|go:"GO:0055088"(lipid homeostasis)|go:"GO:0090108"(positive regulation of high-density lipoprotein particle assembly)|go:"GO:0090187"(positive regulation of pancreatic juice secretion)|go:"GO:0090340"(positive regulation of secretion of lysosomal enzymes)|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|go:"GO:1903573"(negative regulation of response to endoplasmic reticulum stress)|interpro:IPR000536(Nuclear hormone receptor, ligand-binding, core)|interpro:IPR001628(Zinc finger, nuclear hormone receptor-type)|interpro:IPR001723(Steroid hormone receptor)|interpro:IPR013088(Zinc finger, NHR/GATA-type)|interpro:IPR023257|interpro:IPR035500|reactome:R-MMU-383280|reactome:R-MMU-4090294 interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR026082|interpro:IPR030371|interpro:IPR003439(ABC transporter-like)|interpro:IPR017871|interpro:IPR027417|go:"GO:0005524"(ATP binding)|go:"GO:0006869"(lipid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0042626"(ATPase-coupled transmembrane transporter activity)|go:"GO:1903064"(positive regulation of reverse cholesterol transport) go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane) - - figure legend:Fig 3Q|dataset:Affinomics - Interactions curated for the Affinomics consortium.|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-raw264_7)|taxid:10090(Mus musculus monocyte macrophage cell line RAW264) - 2014/05/28 2014/10/16 rogid:XSR7ZWDbMQj6uwWVWI++0pr0Eq810090 rogid:SK5MJMA4MtSSwgtFLqdB0XS1rAs10090 intact-crc:360EDF5E62A89DD6|rigid:XNBqETdzPlE5/AbRqAXACZj5r/0 false - green fluorescent protein tag:?-? - - psi-mi:"MI:0421"(identification by antibody) psi-mi:"MI:0421"(identification by antibody) uniprotkb:O95477 uniprotkb:Q86UK0 intact:EBI-784112|uniprotkb:Q96S56|uniprotkb:Q96T85|uniprotkb:Q9NQV4|uniprotkb:Q9UN06|uniprotkb:Q9UN07|uniprotkb:Q9UN08|uniprotkb:Q9UN09|uniprotkb:Q5VX33|ensembl:ENSP00000363868 intact:EBI-9541582|uniprotkb:Q53QE2|uniprotkb:Q53S55|uniprotkb:Q8IZW6|uniprotkb:Q96JT3|uniprotkb:Q9Y4M5|ensembl:ENSP00000272895 psi-mi:abca1_human(display_long)|uniprotkb:ATP-binding cassette transporter 1(gene name synonym)|uniprotkb:Cholesterol efflux regulatory protein(gene name synonym)|uniprotkb:ABCA1(gene name)|psi-mi:ABCA1(display_short)|uniprotkb:ABC1(gene name synonym)|uniprotkb:CERP(gene name synonym)|uniprotkb:ATP-binding cassette sub-family A member 1(gene name synonym) psi-mi:abcac_human(display_long)|uniprotkb:ABCA12(gene name)|psi-mi:ABCA12(display_short)|uniprotkb:ABC12(gene name synonym)|uniprotkb:ATP-binding cassette transporter 12(gene name synonym)|uniprotkb:ATP-binding cassette sub-family A member 12(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Fu et al. (2013) pubmed:23931754|imex:IM-22610 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:1332"(bhf-ucl) intact:EBI-9541674|imex:IM-22610-3 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_005493.2|dip:DIP-29211N|ensembl:ENSG00000165029(gene)|ensembl:ENST00000374736(transcript)|go:"GO:0002790"(peptide secretion)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005319"(lipid transporter activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005548"(phospholipid transporter activity)|go:"GO:0005768"(endosome)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006497"(protein lipidation)|go:"GO:0006869"(lipid transport)|go:"GO:0006911"(phagocytosis, engulfment)|go:"GO:0007040"(lysosome organization)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007584"(response to nutrient)|go:"GO:0008035"(high-density lipoprotein particle binding)|go:"GO:0008203"(cholesterol metabolic process)|go:"GO:0008320"(protein transmembrane transporter activity)|go:"GO:0009306"(protein secretion)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010745"(negative regulation of macrophage derived foam cell differentiation)|go:"GO:0010875"(positive regulation of cholesterol efflux)|go:"GO:0010887"(negative regulation of cholesterol storage)|go:"GO:0015485"(cholesterol binding)|go:"GO:0016197"(endosomal transport)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0019905"(syntaxin binding)|go:"GO:0023061"(signal release)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0031210"(phosphatidylcholine binding)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032367"(intracellular cholesterol transport)|go:"GO:0032489"(regulation of Cdc42 protein signal transduction)|go:"GO:0033344"(cholesterol efflux)|go:"GO:0033700"(phospholipid efflux)|go:"GO:0034185"(apolipoprotein binding)|go:"GO:0034186"(apolipoprotein A-I binding)|go:"GO:0034188"(apolipoprotein A-I receptor activity)|go:"GO:0034380"(high-density lipoprotein particle assembly)|go:"GO:0034616"(response to laminar fluid shear stress)|go:"GO:0035690"|go:"GO:0042626"(ATPase-coupled transmembrane transporter activity)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043691"(reverse cholesterol transport)|go:"GO:0045121"(membrane raft)|go:"GO:0045332"(phospholipid translocation)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0046623"(sphingolipid floppase activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051117"(ATPase binding)|go:"GO:0055091"(phospholipid homeostasis)|go:"GO:0060155"(platelet dense granule organization)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0071397"(cellular response to cholesterol)|go:"GO:0071404"(cellular response to low-density lipoprotein particle stimulus)|go:"GO:0071806"(protein transmembrane transport)|go:"GO:0090107"(regulation of high-density lipoprotein particle assembly)|go:"GO:0090108"(positive regulation of high-density lipoprotein particle assembly)|go:"GO:0090554"(phosphatidylcholine floppase activity)|go:"GO:0090556"(phosphatidylserine floppase activity)|go:"GO:0097708"(intracellular vesicle)|go:"GO:0120020"(cholesterol transfer activity)|go:"GO:0140115"(export across plasma membrane)|go:"GO:0140328"(floppase activity)|interpro:IPR003439(ABC transporter-like)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR017871|interpro:IPR026082|interpro:IPR027417|interpro:IPR030365|mint:O95477|rcsb pdb:5XJY|reactome:R-HSA-1989781|reactome:R-HSA-5682113|reactome:R-HSA-8963896|reactome:R-HSA-9029569 refseq:NP_056472.2|refseq:NP_775099.2|ensembl:ENSG00000144452(gene)|ensembl:ENST00000272895(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0003336"(corneocyte desquamation)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005319"(lipid transporter activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006672"(ceramide metabolic process)|go:"GO:0006869"(lipid transport)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0010875"(positive regulation of cholesterol efflux)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019725"(cellular homeostasis)|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0031424"(keratinization)|go:"GO:0032379"(positive regulation of intracellular lipid transport)|go:"GO:0032940"(secretion by cell)|go:"GO:0033700"(phospholipid efflux)|go:"GO:0034040"(ATPase-coupled lipid transmembrane transporter activity)|go:"GO:0034191"(apolipoprotein A-I receptor binding)|go:"GO:0035627"(ceramide transport)|go:"GO:0042626"(ATPase-coupled transmembrane transporter activity)|go:"GO:0043129"(surfactant homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045055"(regulated exocytosis)|go:"GO:0045616"(regulation of keratinocyte differentiation)|go:"GO:0048286"(lung alveolus development)|go:"GO:0055088"(lipid homeostasis)|go:"GO:0061178"(regulation of insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0061436"(establishment of skin barrier)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0097209"(epidermal lamellar body)|go:"GO:0097234"(epidermal lamellar body membrane)|go:"GO:0140326"(ATPase-coupled intramembrane lipid transporter activity)|go:"GO:2000010"(positive regulation of protein localization to cell surface)|interpro:IPR003439(ABC transporter-like)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR017871|interpro:IPR026082|interpro:IPR027417|interpro:IPR030371|reactome:R-HSA-1369062|reactome:R-HSA-5682294 go:"GO:0005886"(plasma membrane)|go:"GO:0005737"(cytoplasm) - - figure legend:Fig 4j|dataset:Affinomics - Interactions curated for the Affinomics consortium.|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells) - 2014/05/28 2014/10/16 rogid:DtErjp3P9x9wQEBDIbWae+OkfRc9606 rogid:HZsVBkhHniBgQCaQVvqwlOk18+89606 intact-crc:412EC2E9A2FA798C|rigid:xn5wJyvKUIQh+KMzTKWC0op6xjA false green fluorescent protein tag:?-? - - - psi-mi:"MI:0086"(polyclonal antibody western blot) psi-mi:"MI:0086"(polyclonal antibody western blot)