#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
chebi:"CHEBI:64583"	uniprotkb:F1N588	intact:EBI-9783230	intact:EBI-9786068|ensembl:ENSBTAP00000010706	psi-mi:sphingomyelin(display_short)|psi-mi:"CHEBI:64583"(display_long)	psi-mi:f1n588_bovin(display_long)|uniprotkb:SMPD2(gene name)|psi-mi:SMPD2(display_short)	psi-mi:"MI:1354"(lipase assay)	Ahn et al. (2013)	pubmed:23840630|imex:IM-23089	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9913(bovin)|taxid:9913("Bos taurus (Bovine)")	psi-mi:"MI:1355"(lipid cleavage)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9783195|imex:IM-23089-9	-	-	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensembl:ENSBTAG00000008145(gene)|ensembl:ENSBTAT00000010706(transcript)|go:"GO:0004620"(phospholipase activity)|go:"GO:0004767"(sphingomyelin phosphodiesterase activity)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005901"(caveola)|go:"GO:0006684"(sphingomyelin metabolic process)|go:"GO:0006685"(sphingomyelin catabolic process)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030149"(sphingolipid catabolic process)|go:"GO:0046513"(ceramide biosynthetic process)|go:"GO:0071944"(cell periphery)|interpro:IPR005135(Endonuclease/exonuclease/phosphatase)|interpro:IPR036691|interpro:IPR038772|reactome:R-BTA-1660662	go:"GO:0016298"(lipase activity)|go:"GO:0004767"(sphingomyelin phosphodiesterase activity)|go:"GO:0030149"(sphingolipid catabolic process)	-	-	figure legend:Figure 1,2,3,5|agonist:Ca 2+, Mg2+ and Mn2+  phosphatidylserine|antagonist:"GW4869  (a cell-permeable, non-competitive inhibitor of neutral sphingomyelinases)"|dataset:Affinomics - Interactions curated for the Affinomics consortium.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/09/12	2019/04/15	-	rogid:vtLOgvUozetIfVHJzKcJQiQx3nA9913	intact-crc:80BA5759500191AA	false	14c radiolabel:?-?	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:F1N588	uniprotkb:P31081	intact:EBI-9786068|ensembl:ENSBTAP00000010706	intact:EBI-9816893|ensembl:ENSBTAP00000059077	psi-mi:f1n588_bovin(display_long)|uniprotkb:SMPD2(gene name)|psi-mi:SMPD2(display_short)	psi-mi:ch60_bovin(display_long)|uniprotkb:HSPD1(gene name)|psi-mi:HSPD1(display_short)|uniprotkb:HSP60(gene name synonym)|uniprotkb:60 kDa chaperonin(gene name synonym)|uniprotkb:Chaperonin 60(gene name synonym)|uniprotkb:Heat shock protein 60(gene name synonym)|uniprotkb:Mitochondrial matrix protein P1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Ahn et al. (2013)	pubmed:23840630|imex:IM-23089	taxid:9913(bovin)|taxid:9913("Bos taurus (Bovine)")	taxid:9913(bovin)|taxid:9913("Bos taurus (Bovine)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9816971|imex:IM-23089-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSBTAG00000008145(gene)|ensembl:ENSBTAT00000010706(transcript)|go:"GO:0004620"(phospholipase activity)|go:"GO:0004767"(sphingomyelin phosphodiesterase activity)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005901"(caveola)|go:"GO:0006684"(sphingomyelin metabolic process)|go:"GO:0006685"(sphingomyelin catabolic process)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030149"(sphingolipid catabolic process)|go:"GO:0046513"(ceramide biosynthetic process)|go:"GO:0071944"(cell periphery)|interpro:IPR005135(Endonuclease/exonuclease/phosphatase)|interpro:IPR036691|interpro:IPR038772|reactome:R-BTA-1660662	ensembl:ENSBTAG00000047441(gene)|ensembl:ENSBTAT00000066226(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006457"(protein folding)|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0009409"(response to cold)|go:"GO:0016853"(isomerase activity)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034514"(mitochondrial unfolded protein response)|go:"GO:0042026"(protein refolding)|go:"GO:0042110"(T cell activation)|go:"GO:0045041"(protein import into mitochondrial intermembrane space)|go:"GO:0050870"(positive regulation of T cell activation)|go:"GO:0051087"(chaperone binding)|interpro:IPR001844(Chaperonin Cpn60)|interpro:IPR002423(Chaperonin Cpn60/TCP-1)|interpro:IPR027409|interpro:IPR027410|interpro:IPR027413	-	-	-	figure legend:Figure 4A,5|dataset:Affinomics - Interactions curated for the Affinomics consortium.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9913(bovin-brain)|taxid:9913(Bos taurus brain)	-	2014/09/12	2019/04/15	rogid:vtLOgvUozetIfVHJzKcJQiQx3nA9913	rogid:fG7NpybHMs1k87weQqbBZJgi3LA9913	intact-crc:F6716E2520EA8288|rigid:r3DAyX4wTwtEPI6gu3H/SGZsc3I	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P10809	uniprotkb:Q9JJY3	intact:EBI-352528|ensembl:ENSP00000340019|ensembl:ENSP00000373620|ensembl:ENSP00000396460|ensembl:ENSP00000402478|ensembl:ENSP00000412227|ensembl:ENSP00000412717|ensembl:ENSP00000414446|ensembl:ENSP00000503139|ensembl:ENSP00000503894|uniprotkb:Q38L19|uniprotkb:B2R5M6|uniprotkb:Q9UCR6|uniprotkb:B7Z712	intact:EBI-9817007|uniprotkb:Q3UTQ5|ensembl:ENSMUSP00000069255|ensembl:ENSMUSP00000148282	psi-mi:ch60_human(display_long)|uniprotkb:HSPD1(gene name)|psi-mi:HSPD1(display_short)|uniprotkb:HSP60(gene name synonym)|uniprotkb:Heat shock protein 60(gene name synonym)|uniprotkb:60 kDa chaperonin(gene name synonym)|uniprotkb:Chaperonin 60(gene name synonym)|uniprotkb:Mitochondrial matrix protein P1(gene name synonym)|uniprotkb:P60 lymphocyte protein(gene name synonym)|uniprotkb:HuCHA60(gene name synonym)	psi-mi:nsma2_mouse(display_long)|uniprotkb:Smpd3(gene name)|psi-mi:Smpd3(display_short)|uniprotkb:Neutral sphingomyelinase 2(gene name synonym)|uniprotkb:Neutral sphingomyelinase II(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Ahn et al. (2013)	pubmed:23840630|imex:IM-23089	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9817000|imex:IM-23089-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002147.2|refseq:NP_955472.1|ensembl:ENSG00000144381(gene)|ensembl:ENST00000345042(transcript)|ensembl:ENST00000388968(transcript)|ensembl:ENST00000418022(transcript)|ensembl:ENST00000426480(transcript)|ensembl:ENST00000428204(transcript)|ensembl:ENST00000439605(transcript)|ensembl:ENST00000452200(transcript)|ensembl:ENST00000677913(transcript)|ensembl:ENST00000678761(transcript)|go:"GO:0001530"(lipopolysaccharide binding)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002039"(p53 binding)|go:"GO:0002755"(MyD88-dependent toll-like receptor signaling pathway)|go:"GO:0002842"(positive regulation of T cell mediated immune response to tumor cell)|go:"GO:0002931"(response to ischemia)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033198"(response to ATP)|go:"GO:0034185"(apolipoprotein binding)|go:"GO:0034186"(apolipoprotein A-I binding)|go:"GO:0034514"(mitochondrial unfolded protein response)|go:"GO:0034605"(cellular response to heat)|go:"GO:0042026"(protein refolding)|go:"GO:0042100"(B cell proliferation)|go:"GO:0042110"(T cell activation)|go:"GO:0042113"(B cell activation)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042588"(zymogen granule)|go:"GO:0043032"(positive regulation of macrophage activation)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005769"(early endosome)|go:"GO:0005782"(peroxisomal matrix)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006457"(protein folding)|go:"GO:0006458"('de novo' protein folding)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0008035"(high-density lipoprotein particle binding)|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0009409"(response to cold)|go:"GO:0009986"(cell surface)|go:"GO:0014823"(response to activity)|go:"GO:0016020"(membrane)|go:"GO:0016853"(isomerase activity)|go:"GO:0016887"(ATP hydrolysis activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0030061"(mitochondrial crista)|go:"GO:0030135"(coated vesicle)|go:"GO:0030141"(secretory granule)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031985"(Golgi cisterna)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043627"(response to estrogen)|go:"GO:0045041"(protein import into mitochondrial intermembrane space)|go:"GO:0045121"(membrane raft)|go:"GO:0046696"(lipopolysaccharide receptor complex)|go:"GO:0048291"(isotype switching to IgG isotypes)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050821"(protein stabilization)|go:"GO:0050870"(positive regulation of T cell activation)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051131"(chaperone-mediated protein complex assembly)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0051604"(protein maturation)|go:"GO:0051702"(biological process involved in interaction with symbiont)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071866"(negative regulation of apoptotic process in bone marrow cell)|go:"GO:0097225"(sperm midpiece)|go:"GO:0098761"(cellular response to interleukin-7)|go:"GO:0140030"(modification-dependent protein binding)|go:"GO:1903427"(negative regulation of reactive oxygen species biosynthetic process)|interpro:IPR001844(Chaperonin Cpn60)|interpro:IPR002423(Chaperonin Cpn60/TCP-1)|interpro:IPR018370|interpro:IPR027409|interpro:IPR027410|interpro:IPR027413|mint:P10809|rcsb pdb:4PJ1|rcsb pdb:6HT7|rcsb pdb:6MRC|rcsb pdb:6MRD|rcsb pdb:7AZP|reactome:R-HSA-1268020|reactome:R-HSA-8869496|dip:DIP-58N	dip:DIP-60430N|refseq:NP_067466.1|refseq:XP_006531304.1|refseq:XP_011246764.1|refseq:XP_011246765.1|ensembl:ENSMUSG00000031906(gene)|ensembl:ENSMUST00000067512(transcript)|ensembl:ENSMUST00000212896(transcript)|go:"GO:0000137"(Golgi cis cisterna)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001501"(skeletal system development)|go:"GO:0001503"(ossification)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001958"(endochondral ossification)|go:"GO:0002063"(chondrocyte development)|go:"GO:0002244"(hematopoietic progenitor cell differentiation)|go:"GO:0002685"(regulation of leukocyte migration)|go:"GO:0003433"(chondrocyte development involved in endochondral bone morphogenesis)|go:"GO:0004620"(phospholipase activity)|go:"GO:0004767"(sphingomyelin phosphodiesterase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0006665"(sphingolipid metabolic process)|go:"GO:0006672"(ceramide metabolic process)|go:"GO:0006684"(sphingomyelin metabolic process)|go:"GO:0006685"(sphingomyelin catabolic process)|go:"GO:0007165"(signal transduction)|go:"GO:0014824"(artery smooth muscle contraction)|go:"GO:0015774"(polysaccharide transport)|go:"GO:0016020"(membrane)|go:"GO:0030072"(peptide hormone secretion)|go:"GO:0030282"(bone mineralization)|go:"GO:0030324"(lung development)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0032963"(collagen metabolic process)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0042802"(identical protein binding)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0045840"(positive regulation of mitotic nuclear division)|go:"GO:0046872"(metal ion binding)|go:"GO:0048008"(platelet-derived growth factor receptor signaling pathway)|go:"GO:0048286"(lung alveolus development)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0051216"(cartilage development)|go:"GO:0051481"(negative regulation of cytosolic calcium ion concentration)|go:"GO:0060348"(bone development)|go:"GO:0060541"(respiratory system development)|go:"GO:0061035"(regulation of cartilage development)|go:"GO:0061751"(neutral sphingomyelin phosphodiesterase activity)|go:"GO:0070300"(phosphatidic acid binding)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0070314"(G1 to G0 transition)|go:"GO:0071286"(cellular response to magnesium ion)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071461"(cellular response to redox state)|go:"GO:0071897"(DNA biosynthetic process)|go:"GO:0085029"(extracellular matrix assembly)|go:"GO:0090494"(dopamine uptake)|go:"GO:0090520"(sphingolipid mediated signaling pathway)|go:"GO:0097187"(dentinogenesis)|go:"GO:0098868"(bone growth)|go:"GO:0140014"(mitotic nuclear division)|go:"GO:0140052"(cellular response to oxidised low-density lipoprotein particle stimulus)|go:"GO:1900125"(regulation of hyaluronan biosynthetic process)|go:"GO:1900126"(negative regulation of hyaluronan biosynthetic process)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1901653"(cellular response to peptide)|go:"GO:1903543"(positive regulation of exosomal secretion)|go:"GO:2000304"(positive regulation of ceramide biosynthetic process)|interpro:IPR005135(Endonuclease/exonuclease/phosphatase)|interpro:IPR017766(Sphingomyelinase)|interpro:IPR036691|reactome:R-MMU-1660662|reactome:R-MMU-5626978|go:"GO:0005737"(cytoplasm)	-	-	-	figure legend:Figure 6|dataset:Affinomics - Interactions curated for the Affinomics consortium.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2014/09/12	2014/10/16	rogid:syB2vt66Cpr2mJROfbxoPevoiRE9606	rogid:WT7JRQygwfAUbgJQF42WcrEP91Q10090	intact-crc:3CD631F2BED3C0A4|rigid:/g4iDZnqJJgKUOys9ej40wK2sto	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P31081	uniprotkb:F1N588	intact:EBI-9816893|ensembl:ENSBTAP00000059077	intact:EBI-9786068|ensembl:ENSBTAP00000010706	psi-mi:ch60_bovin(display_long)|uniprotkb:HSPD1(gene name)|psi-mi:HSPD1(display_short)|uniprotkb:HSP60(gene name synonym)|uniprotkb:60 kDa chaperonin(gene name synonym)|uniprotkb:Chaperonin 60(gene name synonym)|uniprotkb:Heat shock protein 60(gene name synonym)|uniprotkb:Mitochondrial matrix protein P1(gene name synonym)	psi-mi:f1n588_bovin(display_long)|uniprotkb:SMPD2(gene name)|psi-mi:SMPD2(display_short)	psi-mi:"MI:0091"(chromatography technology)	Ahn et al. (2013)	pubmed:23840630|imex:IM-23089	taxid:9913(bovin)|taxid:9913("Bos taurus (Bovine)")	taxid:9913(bovin)|taxid:9913("Bos taurus (Bovine)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9816924|imex:IM-23089-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSBTAG00000047441(gene)|ensembl:ENSBTAT00000066226(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006457"(protein folding)|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0009409"(response to cold)|go:"GO:0016853"(isomerase activity)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034514"(mitochondrial unfolded protein response)|go:"GO:0042026"(protein refolding)|go:"GO:0042110"(T cell activation)|go:"GO:0045041"(protein import into mitochondrial intermembrane space)|go:"GO:0050870"(positive regulation of T cell activation)|go:"GO:0051087"(chaperone binding)|interpro:IPR001844(Chaperonin Cpn60)|interpro:IPR002423(Chaperonin Cpn60/TCP-1)|interpro:IPR027409|interpro:IPR027410|interpro:IPR027413	ensembl:ENSBTAG00000008145(gene)|ensembl:ENSBTAT00000010706(transcript)|go:"GO:0004620"(phospholipase activity)|go:"GO:0004767"(sphingomyelin phosphodiesterase activity)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005901"(caveola)|go:"GO:0006684"(sphingomyelin metabolic process)|go:"GO:0006685"(sphingomyelin catabolic process)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030149"(sphingolipid catabolic process)|go:"GO:0046513"(ceramide biosynthetic process)|go:"GO:0071944"(cell periphery)|interpro:IPR005135(Endonuclease/exonuclease/phosphatase)|interpro:IPR036691|interpro:IPR038772|reactome:R-BTA-1660662	-	-	-	figure legend:Figure 3|dataset:Affinomics - Interactions curated for the Affinomics consortium.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9913(bovin-brain)|taxid:9913(Bos taurus brain)	-	2014/09/12	2019/04/15	rogid:fG7NpybHMs1k87weQqbBZJgi3LA9913	rogid:vtLOgvUozetIfVHJzKcJQiQx3nA9913	intact-crc:7946555638606231|rigid:r3DAyX4wTwtEPI6gu3H/SGZsc3I	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:F1N588	uniprotkb:P31081	intact:EBI-9786068|ensembl:ENSBTAP00000010706	intact:EBI-9816893|ensembl:ENSBTAP00000059077	psi-mi:f1n588_bovin(display_long)|uniprotkb:SMPD2(gene name)|psi-mi:SMPD2(display_short)	psi-mi:ch60_bovin(display_long)|uniprotkb:HSPD1(gene name)|psi-mi:HSPD1(display_short)|uniprotkb:HSP60(gene name synonym)|uniprotkb:60 kDa chaperonin(gene name synonym)|uniprotkb:Chaperonin 60(gene name synonym)|uniprotkb:Heat shock protein 60(gene name synonym)|uniprotkb:Mitochondrial matrix protein P1(gene name synonym)	psi-mi:"MI:0091"(chromatography technology)	Ahn et al. (2013)	pubmed:23840630|imex:IM-23089	taxid:9913(bovin)|taxid:9913("Bos taurus (Bovine)")	taxid:9913(bovin)|taxid:9913("Bos taurus (Bovine)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9816887|imex:IM-23089-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSBTAG00000008145(gene)|ensembl:ENSBTAT00000010706(transcript)|go:"GO:0004620"(phospholipase activity)|go:"GO:0004767"(sphingomyelin phosphodiesterase activity)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005901"(caveola)|go:"GO:0006684"(sphingomyelin metabolic process)|go:"GO:0006685"(sphingomyelin catabolic process)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030149"(sphingolipid catabolic process)|go:"GO:0046513"(ceramide biosynthetic process)|go:"GO:0071944"(cell periphery)|interpro:IPR005135(Endonuclease/exonuclease/phosphatase)|interpro:IPR036691|interpro:IPR038772|reactome:R-BTA-1660662	ensembl:ENSBTAG00000047441(gene)|ensembl:ENSBTAT00000066226(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006457"(protein folding)|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0009409"(response to cold)|go:"GO:0016853"(isomerase activity)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034514"(mitochondrial unfolded protein response)|go:"GO:0042026"(protein refolding)|go:"GO:0042110"(T cell activation)|go:"GO:0045041"(protein import into mitochondrial intermembrane space)|go:"GO:0050870"(positive regulation of T cell activation)|go:"GO:0051087"(chaperone binding)|interpro:IPR001844(Chaperonin Cpn60)|interpro:IPR002423(Chaperonin Cpn60/TCP-1)|interpro:IPR027409|interpro:IPR027410|interpro:IPR027413	-	-	-	figure legend:Figure 1D|dataset:Affinomics - Interactions curated for the Affinomics consortium.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9913(bovin-brain)|taxid:9913(Bos taurus brain)	-	2014/09/12	2019/04/15	rogid:vtLOgvUozetIfVHJzKcJQiQx3nA9913	rogid:fG7NpybHMs1k87weQqbBZJgi3LA9913	intact-crc:114DF4FEA7A15159|rigid:r3DAyX4wTwtEPI6gu3H/SGZsc3I	false	-	-	-	-	psi-mi:"MI:0082"(peptide massfingerprinting)	psi-mi:"MI:0082"(peptide massfingerprinting)
uniprotkb:F1N588	uniprotkb:P31081	intact:EBI-9786068|ensembl:ENSBTAP00000010706	intact:EBI-9816893|ensembl:ENSBTAP00000059077	psi-mi:f1n588_bovin(display_long)|uniprotkb:SMPD2(gene name)|psi-mi:SMPD2(display_short)	psi-mi:ch60_bovin(display_long)|uniprotkb:HSPD1(gene name)|psi-mi:HSPD1(display_short)|uniprotkb:HSP60(gene name synonym)|uniprotkb:60 kDa chaperonin(gene name synonym)|uniprotkb:Chaperonin 60(gene name synonym)|uniprotkb:Heat shock protein 60(gene name synonym)|uniprotkb:Mitochondrial matrix protein P1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Ahn et al. (2013)	pubmed:23840630|imex:IM-23089	taxid:9913(bovin)|taxid:9913("Bos taurus (Bovine)")	taxid:9913(bovin)|taxid:9913("Bos taurus (Bovine)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9816986|imex:IM-23089-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSBTAG00000008145(gene)|ensembl:ENSBTAT00000010706(transcript)|go:"GO:0004620"(phospholipase activity)|go:"GO:0004767"(sphingomyelin phosphodiesterase activity)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005901"(caveola)|go:"GO:0006684"(sphingomyelin metabolic process)|go:"GO:0006685"(sphingomyelin catabolic process)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030149"(sphingolipid catabolic process)|go:"GO:0046513"(ceramide biosynthetic process)|go:"GO:0071944"(cell periphery)|interpro:IPR005135(Endonuclease/exonuclease/phosphatase)|interpro:IPR036691|interpro:IPR038772|reactome:R-BTA-1660662	ensembl:ENSBTAG00000047441(gene)|ensembl:ENSBTAT00000066226(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006457"(protein folding)|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0009409"(response to cold)|go:"GO:0016853"(isomerase activity)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034514"(mitochondrial unfolded protein response)|go:"GO:0042026"(protein refolding)|go:"GO:0042110"(T cell activation)|go:"GO:0045041"(protein import into mitochondrial intermembrane space)|go:"GO:0050870"(positive regulation of T cell activation)|go:"GO:0051087"(chaperone binding)|interpro:IPR001844(Chaperonin Cpn60)|interpro:IPR002423(Chaperonin Cpn60/TCP-1)|interpro:IPR027409|interpro:IPR027410|interpro:IPR027413	-	-	-	figure legend:Figure 4C|dataset:Affinomics - Interactions curated for the Affinomics consortium.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9913(bovin-brain)|taxid:9913(Bos taurus brain)	-	2014/09/12	2019/04/15	rogid:vtLOgvUozetIfVHJzKcJQiQx3nA9913	rogid:fG7NpybHMs1k87weQqbBZJgi3LA9913	intact-crc:2978CD30A96DA45E|rigid:r3DAyX4wTwtEPI6gu3H/SGZsc3I	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:F1N588	uniprotkb:P31081	intact:EBI-9786068|ensembl:ENSBTAP00000010706	intact:EBI-9816893|ensembl:ENSBTAP00000059077	psi-mi:f1n588_bovin(display_long)|uniprotkb:SMPD2(gene name)|psi-mi:SMPD2(display_short)	psi-mi:ch60_bovin(display_long)|uniprotkb:HSPD1(gene name)|psi-mi:HSPD1(display_short)|uniprotkb:HSP60(gene name synonym)|uniprotkb:60 kDa chaperonin(gene name synonym)|uniprotkb:Chaperonin 60(gene name synonym)|uniprotkb:Heat shock protein 60(gene name synonym)|uniprotkb:Mitochondrial matrix protein P1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Ahn et al. (2013)	pubmed:23840630|imex:IM-23089	taxid:9913(bovin)|taxid:9913("Bos taurus (Bovine)")	taxid:9913(bovin)|taxid:9913("Bos taurus (Bovine)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9979023|imex:IM-23089-8	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSBTAG00000008145(gene)|ensembl:ENSBTAT00000010706(transcript)|go:"GO:0004620"(phospholipase activity)|go:"GO:0004767"(sphingomyelin phosphodiesterase activity)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005901"(caveola)|go:"GO:0006684"(sphingomyelin metabolic process)|go:"GO:0006685"(sphingomyelin catabolic process)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030149"(sphingolipid catabolic process)|go:"GO:0046513"(ceramide biosynthetic process)|go:"GO:0071944"(cell periphery)|interpro:IPR005135(Endonuclease/exonuclease/phosphatase)|interpro:IPR036691|interpro:IPR038772|reactome:R-BTA-1660662	ensembl:ENSBTAG00000047441(gene)|ensembl:ENSBTAT00000066226(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006457"(protein folding)|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0009409"(response to cold)|go:"GO:0016853"(isomerase activity)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034514"(mitochondrial unfolded protein response)|go:"GO:0042026"(protein refolding)|go:"GO:0042110"(T cell activation)|go:"GO:0045041"(protein import into mitochondrial intermembrane space)|go:"GO:0050870"(positive regulation of T cell activation)|go:"GO:0051087"(chaperone binding)|interpro:IPR001844(Chaperonin Cpn60)|interpro:IPR002423(Chaperonin Cpn60/TCP-1)|interpro:IPR027409|interpro:IPR027410|interpro:IPR027413	-	-	-	figure legend:Figure 4C|dataset:Affinomics - Interactions curated for the Affinomics consortium.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9913(bovin-brain)|taxid:9913(Bos taurus brain)	-	2014/09/12	2019/04/15	rogid:vtLOgvUozetIfVHJzKcJQiQx3nA9913	rogid:fG7NpybHMs1k87weQqbBZJgi3LA9913	intact-crc:84BD9EE7C76FEC3C|rigid:r3DAyX4wTwtEPI6gu3H/SGZsc3I	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9JJY3	uniprotkb:P10809	intact:EBI-9817007|uniprotkb:Q3UTQ5|ensembl:ENSMUSP00000069255|ensembl:ENSMUSP00000148282	intact:EBI-352528|ensembl:ENSP00000340019|ensembl:ENSP00000373620|ensembl:ENSP00000396460|ensembl:ENSP00000402478|ensembl:ENSP00000412227|ensembl:ENSP00000412717|ensembl:ENSP00000414446|ensembl:ENSP00000503139|ensembl:ENSP00000503894|uniprotkb:Q38L19|uniprotkb:B2R5M6|uniprotkb:Q9UCR6|uniprotkb:B7Z712	psi-mi:nsma2_mouse(display_long)|uniprotkb:Smpd3(gene name)|psi-mi:Smpd3(display_short)|uniprotkb:Neutral sphingomyelinase 2(gene name synonym)|uniprotkb:Neutral sphingomyelinase II(gene name synonym)	psi-mi:ch60_human(display_long)|uniprotkb:HSPD1(gene name)|psi-mi:HSPD1(display_short)|uniprotkb:HSP60(gene name synonym)|uniprotkb:Heat shock protein 60(gene name synonym)|uniprotkb:60 kDa chaperonin(gene name synonym)|uniprotkb:Chaperonin 60(gene name synonym)|uniprotkb:Mitochondrial matrix protein P1(gene name synonym)|uniprotkb:P60 lymphocyte protein(gene name synonym)|uniprotkb:HuCHA60(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Ahn et al. (2013)	pubmed:23840630|imex:IM-23089	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9817043|imex:IM-23089-6	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	dip:DIP-60430N|refseq:NP_067466.1|refseq:XP_006531304.1|refseq:XP_011246764.1|refseq:XP_011246765.1|ensembl:ENSMUSG00000031906(gene)|ensembl:ENSMUST00000067512(transcript)|ensembl:ENSMUST00000212896(transcript)|go:"GO:0000137"(Golgi cis cisterna)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001501"(skeletal system development)|go:"GO:0001503"(ossification)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001958"(endochondral ossification)|go:"GO:0002063"(chondrocyte development)|go:"GO:0002244"(hematopoietic progenitor cell differentiation)|go:"GO:0002685"(regulation of leukocyte migration)|go:"GO:0003433"(chondrocyte development involved in endochondral bone morphogenesis)|go:"GO:0004620"(phospholipase activity)|go:"GO:0004767"(sphingomyelin phosphodiesterase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0006665"(sphingolipid metabolic process)|go:"GO:0006672"(ceramide metabolic process)|go:"GO:0006684"(sphingomyelin metabolic process)|go:"GO:0006685"(sphingomyelin catabolic process)|go:"GO:0007165"(signal transduction)|go:"GO:0014824"(artery smooth muscle contraction)|go:"GO:0015774"(polysaccharide transport)|go:"GO:0016020"(membrane)|go:"GO:0030072"(peptide hormone secretion)|go:"GO:0030282"(bone mineralization)|go:"GO:0030324"(lung development)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0032963"(collagen metabolic process)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0042802"(identical protein binding)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0045840"(positive regulation of mitotic nuclear division)|go:"GO:0046872"(metal ion binding)|go:"GO:0048008"(platelet-derived growth factor receptor signaling pathway)|go:"GO:0048286"(lung alveolus development)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0051216"(cartilage development)|go:"GO:0051481"(negative regulation of cytosolic calcium ion concentration)|go:"GO:0060348"(bone development)|go:"GO:0060541"(respiratory system development)|go:"GO:0061035"(regulation of cartilage development)|go:"GO:0061751"(neutral sphingomyelin phosphodiesterase activity)|go:"GO:0070300"(phosphatidic acid binding)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0070314"(G1 to G0 transition)|go:"GO:0071286"(cellular response to magnesium ion)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071461"(cellular response to redox state)|go:"GO:0071897"(DNA biosynthetic process)|go:"GO:0085029"(extracellular matrix assembly)|go:"GO:0090494"(dopamine uptake)|go:"GO:0090520"(sphingolipid mediated signaling pathway)|go:"GO:0097187"(dentinogenesis)|go:"GO:0098868"(bone growth)|go:"GO:0140014"(mitotic nuclear division)|go:"GO:0140052"(cellular response to oxidised low-density lipoprotein particle stimulus)|go:"GO:1900125"(regulation of hyaluronan biosynthetic process)|go:"GO:1900126"(negative regulation of hyaluronan biosynthetic process)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1901653"(cellular response to peptide)|go:"GO:1903543"(positive regulation of exosomal secretion)|go:"GO:2000304"(positive regulation of ceramide biosynthetic process)|interpro:IPR005135(Endonuclease/exonuclease/phosphatase)|interpro:IPR017766(Sphingomyelinase)|interpro:IPR036691|reactome:R-MMU-1660662|reactome:R-MMU-5626978|go:"GO:0005737"(cytoplasm)	refseq:NP_002147.2|refseq:NP_955472.1|ensembl:ENSG00000144381(gene)|ensembl:ENST00000345042(transcript)|ensembl:ENST00000388968(transcript)|ensembl:ENST00000418022(transcript)|ensembl:ENST00000426480(transcript)|ensembl:ENST00000428204(transcript)|ensembl:ENST00000439605(transcript)|ensembl:ENST00000452200(transcript)|ensembl:ENST00000677913(transcript)|ensembl:ENST00000678761(transcript)|go:"GO:0001530"(lipopolysaccharide binding)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002039"(p53 binding)|go:"GO:0002755"(MyD88-dependent toll-like receptor signaling pathway)|go:"GO:0002842"(positive regulation of T cell mediated immune response to tumor cell)|go:"GO:0002931"(response to ischemia)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033198"(response to ATP)|go:"GO:0034185"(apolipoprotein binding)|go:"GO:0034186"(apolipoprotein A-I binding)|go:"GO:0034514"(mitochondrial unfolded protein response)|go:"GO:0034605"(cellular response to heat)|go:"GO:0042026"(protein refolding)|go:"GO:0042100"(B cell proliferation)|go:"GO:0042110"(T cell activation)|go:"GO:0042113"(B cell activation)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042588"(zymogen granule)|go:"GO:0043032"(positive regulation of macrophage activation)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005769"(early endosome)|go:"GO:0005782"(peroxisomal matrix)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006457"(protein folding)|go:"GO:0006458"('de novo' protein folding)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0008035"(high-density lipoprotein particle binding)|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0009409"(response to cold)|go:"GO:0009986"(cell surface)|go:"GO:0014823"(response to activity)|go:"GO:0016020"(membrane)|go:"GO:0016853"(isomerase activity)|go:"GO:0016887"(ATP hydrolysis activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0030061"(mitochondrial crista)|go:"GO:0030135"(coated vesicle)|go:"GO:0030141"(secretory granule)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031985"(Golgi cisterna)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043627"(response to estrogen)|go:"GO:0045041"(protein import into mitochondrial intermembrane space)|go:"GO:0045121"(membrane raft)|go:"GO:0046696"(lipopolysaccharide receptor complex)|go:"GO:0048291"(isotype switching to IgG isotypes)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050821"(protein stabilization)|go:"GO:0050870"(positive regulation of T cell activation)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051131"(chaperone-mediated protein complex assembly)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0051604"(protein maturation)|go:"GO:0051702"(biological process involved in interaction with symbiont)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071866"(negative regulation of apoptotic process in bone marrow cell)|go:"GO:0097225"(sperm midpiece)|go:"GO:0098761"(cellular response to interleukin-7)|go:"GO:0140030"(modification-dependent protein binding)|go:"GO:1903427"(negative regulation of reactive oxygen species biosynthetic process)|interpro:IPR001844(Chaperonin Cpn60)|interpro:IPR002423(Chaperonin Cpn60/TCP-1)|interpro:IPR018370|interpro:IPR027409|interpro:IPR027410|interpro:IPR027413|mint:P10809|rcsb pdb:4PJ1|rcsb pdb:6HT7|rcsb pdb:6MRC|rcsb pdb:6MRD|rcsb pdb:7AZP|reactome:R-HSA-1268020|reactome:R-HSA-8869496|dip:DIP-58N	-	-	-	figure legend:Figure 6|dataset:Affinomics - Interactions curated for the Affinomics consortium.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2014/09/12	2014/10/16	rogid:WT7JRQygwfAUbgJQF42WcrEP91Q10090	rogid:syB2vt66Cpr2mJROfbxoPevoiRE9606	intact-crc:43B7235F249A29A9|rigid:/g4iDZnqJJgKUOys9ej40wK2sto	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P10809	uniprotkb:Q9JJY3	intact:EBI-352528|ensembl:ENSP00000340019|ensembl:ENSP00000373620|ensembl:ENSP00000396460|ensembl:ENSP00000402478|ensembl:ENSP00000412227|ensembl:ENSP00000412717|ensembl:ENSP00000414446|ensembl:ENSP00000503139|ensembl:ENSP00000503894|uniprotkb:Q38L19|uniprotkb:B2R5M6|uniprotkb:Q9UCR6|uniprotkb:B7Z712	intact:EBI-9817007|uniprotkb:Q3UTQ5|ensembl:ENSMUSP00000069255|ensembl:ENSMUSP00000148282	psi-mi:ch60_human(display_long)|uniprotkb:HSPD1(gene name)|psi-mi:HSPD1(display_short)|uniprotkb:HSP60(gene name synonym)|uniprotkb:Heat shock protein 60(gene name synonym)|uniprotkb:60 kDa chaperonin(gene name synonym)|uniprotkb:Chaperonin 60(gene name synonym)|uniprotkb:Mitochondrial matrix protein P1(gene name synonym)|uniprotkb:P60 lymphocyte protein(gene name synonym)|uniprotkb:HuCHA60(gene name synonym)	psi-mi:nsma2_mouse(display_long)|uniprotkb:Smpd3(gene name)|psi-mi:Smpd3(display_short)|uniprotkb:Neutral sphingomyelinase 2(gene name synonym)|uniprotkb:Neutral sphingomyelinase II(gene name synonym)	psi-mi:"MI:0813"(proximity ligation assay)	Ahn et al. (2013)	pubmed:23840630|imex:IM-23089	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9817058|imex:IM-23089-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002147.2|refseq:NP_955472.1|ensembl:ENSG00000144381(gene)|ensembl:ENST00000345042(transcript)|ensembl:ENST00000388968(transcript)|ensembl:ENST00000418022(transcript)|ensembl:ENST00000426480(transcript)|ensembl:ENST00000428204(transcript)|ensembl:ENST00000439605(transcript)|ensembl:ENST00000452200(transcript)|ensembl:ENST00000677913(transcript)|ensembl:ENST00000678761(transcript)|go:"GO:0001530"(lipopolysaccharide binding)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002039"(p53 binding)|go:"GO:0002755"(MyD88-dependent toll-like receptor signaling pathway)|go:"GO:0002842"(positive regulation of T cell mediated immune response to tumor cell)|go:"GO:0002931"(response to ischemia)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033198"(response to ATP)|go:"GO:0034185"(apolipoprotein binding)|go:"GO:0034186"(apolipoprotein A-I binding)|go:"GO:0034514"(mitochondrial unfolded protein response)|go:"GO:0034605"(cellular response to heat)|go:"GO:0042026"(protein refolding)|go:"GO:0042100"(B cell proliferation)|go:"GO:0042110"(T cell activation)|go:"GO:0042113"(B cell activation)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042588"(zymogen granule)|go:"GO:0043032"(positive regulation of macrophage activation)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005769"(early endosome)|go:"GO:0005782"(peroxisomal matrix)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006457"(protein folding)|go:"GO:0006458"('de novo' protein folding)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0008035"(high-density lipoprotein particle binding)|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0009409"(response to cold)|go:"GO:0009986"(cell surface)|go:"GO:0014823"(response to activity)|go:"GO:0016020"(membrane)|go:"GO:0016853"(isomerase activity)|go:"GO:0016887"(ATP hydrolysis activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0030061"(mitochondrial crista)|go:"GO:0030135"(coated vesicle)|go:"GO:0030141"(secretory granule)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031985"(Golgi cisterna)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043627"(response to estrogen)|go:"GO:0045041"(protein import into mitochondrial intermembrane space)|go:"GO:0045121"(membrane raft)|go:"GO:0046696"(lipopolysaccharide receptor complex)|go:"GO:0048291"(isotype switching to IgG isotypes)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050821"(protein stabilization)|go:"GO:0050870"(positive regulation of T cell activation)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051131"(chaperone-mediated protein complex assembly)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0051604"(protein maturation)|go:"GO:0051702"(biological process involved in interaction with symbiont)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071866"(negative regulation of apoptotic process in bone marrow cell)|go:"GO:0097225"(sperm midpiece)|go:"GO:0098761"(cellular response to interleukin-7)|go:"GO:0140030"(modification-dependent protein binding)|go:"GO:1903427"(negative regulation of reactive oxygen species biosynthetic process)|interpro:IPR001844(Chaperonin Cpn60)|interpro:IPR002423(Chaperonin Cpn60/TCP-1)|interpro:IPR018370|interpro:IPR027409|interpro:IPR027410|interpro:IPR027413|mint:P10809|rcsb pdb:4PJ1|rcsb pdb:6HT7|rcsb pdb:6MRC|rcsb pdb:6MRD|rcsb pdb:7AZP|reactome:R-HSA-1268020|reactome:R-HSA-8869496|dip:DIP-58N	dip:DIP-60430N|refseq:NP_067466.1|refseq:XP_006531304.1|refseq:XP_011246764.1|refseq:XP_011246765.1|ensembl:ENSMUSG00000031906(gene)|ensembl:ENSMUST00000067512(transcript)|ensembl:ENSMUST00000212896(transcript)|go:"GO:0000137"(Golgi cis cisterna)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001501"(skeletal system development)|go:"GO:0001503"(ossification)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001958"(endochondral ossification)|go:"GO:0002063"(chondrocyte development)|go:"GO:0002244"(hematopoietic progenitor cell differentiation)|go:"GO:0002685"(regulation of leukocyte migration)|go:"GO:0003433"(chondrocyte development involved in endochondral bone morphogenesis)|go:"GO:0004620"(phospholipase activity)|go:"GO:0004767"(sphingomyelin phosphodiesterase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0006665"(sphingolipid metabolic process)|go:"GO:0006672"(ceramide metabolic process)|go:"GO:0006684"(sphingomyelin metabolic process)|go:"GO:0006685"(sphingomyelin catabolic process)|go:"GO:0007165"(signal transduction)|go:"GO:0014824"(artery smooth muscle contraction)|go:"GO:0015774"(polysaccharide transport)|go:"GO:0016020"(membrane)|go:"GO:0030072"(peptide hormone secretion)|go:"GO:0030282"(bone mineralization)|go:"GO:0030324"(lung development)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0032963"(collagen metabolic process)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0042802"(identical protein binding)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0045840"(positive regulation of mitotic nuclear division)|go:"GO:0046872"(metal ion binding)|go:"GO:0048008"(platelet-derived growth factor receptor signaling pathway)|go:"GO:0048286"(lung alveolus development)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0051216"(cartilage development)|go:"GO:0051481"(negative regulation of cytosolic calcium ion concentration)|go:"GO:0060348"(bone development)|go:"GO:0060541"(respiratory system development)|go:"GO:0061035"(regulation of cartilage development)|go:"GO:0061751"(neutral sphingomyelin phosphodiesterase activity)|go:"GO:0070300"(phosphatidic acid binding)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0070314"(G1 to G0 transition)|go:"GO:0071286"(cellular response to magnesium ion)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071461"(cellular response to redox state)|go:"GO:0071897"(DNA biosynthetic process)|go:"GO:0085029"(extracellular matrix assembly)|go:"GO:0090494"(dopamine uptake)|go:"GO:0090520"(sphingolipid mediated signaling pathway)|go:"GO:0097187"(dentinogenesis)|go:"GO:0098868"(bone growth)|go:"GO:0140014"(mitotic nuclear division)|go:"GO:0140052"(cellular response to oxidised low-density lipoprotein particle stimulus)|go:"GO:1900125"(regulation of hyaluronan biosynthetic process)|go:"GO:1900126"(negative regulation of hyaluronan biosynthetic process)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1901653"(cellular response to peptide)|go:"GO:1903543"(positive regulation of exosomal secretion)|go:"GO:2000304"(positive regulation of ceramide biosynthetic process)|interpro:IPR005135(Endonuclease/exonuclease/phosphatase)|interpro:IPR017766(Sphingomyelinase)|interpro:IPR036691|reactome:R-MMU-1660662|reactome:R-MMU-5626978|go:"GO:0005737"(cytoplasm)	go:"GO:0005622"(intracellular anatomical structure)	-	-	figure legend:Figure 8B, supp 3.|dataset:Affinomics - Interactions curated for the Affinomics consortium.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2014/09/12	2014/10/16	rogid:syB2vt66Cpr2mJROfbxoPevoiRE9606	rogid:WT7JRQygwfAUbgJQF42WcrEP91Q10090	intact-crc:C845A9C4F82C9E43|rigid:/g4iDZnqJJgKUOys9ej40wK2sto	false	-	-	-	-	psi-mi:"MI:0421"(identification by antibody)	psi-mi:"MI:0421"(identification by antibody)