#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
ensembl:ENSG00000143819	uniprotkb:P41235	intact:EBI-9992401	intact:EBI-1049011|uniprotkb:Q92654|uniprotkb:Q92655|uniprotkb:Q99864|uniprotkb:Q9NQH0|uniprotkb:O00659|uniprotkb:O00723|uniprotkb:Q14540|uniprotkb:Q5QPB8|uniprotkb:Q6B4V5|uniprotkb:Q6B4V6|uniprotkb:Q6B4V7|uniprotkb:Q92653|uniprotkb:A5JW41|uniprotkb:B2RPP8|ensembl:ENSP00000312987	psi-mi:hyep_human_gene(display_short)|psi-mi:ENSG00000143819(display_long)	psi-mi:hnf4a_human(display_long)|uniprotkb:Transcription factor HNF-4(gene name synonym)|uniprotkb:Nuclear receptor subfamily 2 group A member 1(gene name synonym)|uniprotkb:Transcription factor 14(gene name synonym)|uniprotkb:HNF4A(gene name)|psi-mi:HNF4A(display_short)|uniprotkb:HNF4(gene name synonym)|uniprotkb:NR2A1(gene name synonym)|uniprotkb:TCF14(gene name synonym)	psi-mi:"MI:0402"(chromatin immunoprecipitation assay)	Peng et al. (2013)	pubmed:23714182|imex:IM-23351	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9992403|imex:IM-23351-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0250"(gene)	psi-mi:"MI:0326"(protein)	-	refseq:NP_000448.3|refseq:NP_001025174.1|refseq:NP_001025175.1|refseq:NP_787110.2|refseq:NP_849181.1|refseq:NP_001274111.1|refseq:NP_001274112.1|refseq:NP_001274113.1|refseq:NP_001245284.1|ensembl:ENSG00000101076(gene)|ensembl:ENST00000316099(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003323"(type B pancreatic cell development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0004879"(nuclear receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005504"(fatty acid binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006591"(ornithine metabolic process)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0006805"(xenobiotic metabolic process)|go:"GO:0007548"(sex differentiation)|go:"GO:0007596"(blood coagulation)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009749"(response to glucose)|go:"GO:0010470"(regulation of gastrulation)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0023019"(signal transduction involved in regulation of gene expression)|go:"GO:0030154"(cell differentiation)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048511"(rhythmic process)|go:"GO:0048856"(anatomical structure development)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0055088"(lipid homeostasis)|go:"GO:0055091"(phospholipid homeostasis)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0060398"(regulation of growth hormone receptor signaling pathway)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070328"(triglyceride homeostasis)|go:"GO:0070365"(hepatocyte differentiation)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000536(Nuclear hormone receptor, ligand-binding, core)|interpro:IPR001628(Zinc finger, nuclear hormone receptor-type)|interpro:IPR001723(Steroid hormone receptor)|interpro:IPR013088(Zinc finger, NHR/GATA-type)|interpro:IPR035500|interpro:IPR039067|mint:P41235|rcsb pdb:1PZL|rcsb pdb:3CBB|rcsb pdb:3FS1|rcsb pdb:4B7W|rcsb pdb:4IQR|rcsb pdb:6CHT|reactome:R-HSA-210745|reactome:R-HSA-383280|dip:DIP-499N	-	-	-	figure legend:Fig. 5b|causality statement:P41235 increases expression at RNA level of ENSG00000143819|dataset:Ulcerative colitis - Interactions of proteins identified as having a link to ulcerative colitis|dataset:IBD - Inflammatory bowel disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hep_g2)|taxid:9606("Homo sapiens hepatocellular carcinoma (HCC) cells (p53-wt).")	-	2014/11/30	2014/11/30	-	rogid:lul0rM/fHNAVsH3ZizbMOXPPL0k9606	intact-crc:6554D3320537F0E0	false	binding-associated region:?-?	-	-	-	psi-mi:"MI:0088"(primer specific pcr)	psi-mi:"MI:0088"(primer specific pcr)
ensembl:ENSG00000143819	uniprotkb:P23246	intact:EBI-9992401	intact:EBI-355453|uniprotkb:P30808|uniprotkb:Q5SZ71|ensembl:ENSP00000349748	psi-mi:hyep_human_gene(display_short)|psi-mi:ENSG00000143819(display_long)	psi-mi:sfpq_human(display_long)|uniprotkb:SFPQ(gene name)|psi-mi:SFPQ(display_short)|uniprotkb:PSF(gene name synonym)|uniprotkb:Polypyrimidine tract-binding protein-associated-splicing factor(gene name synonym)|uniprotkb:DNA-binding p52/p100 complex, 100 kDa subunit(gene name synonym)|uniprotkb:100 kDa DNA-pairing protein(gene name synonym)	psi-mi:"MI:0402"(chromatin immunoprecipitation assay)	Peng et al. (2013)	pubmed:23714182|imex:IM-23351	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9992409|imex:IM-23351-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0250"(gene)	psi-mi:"MI:0326"(protein)	-	refseq:NP_005057.1|ensembl:ENSG00000116560(gene)|ensembl:ENST00000357214(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000380"(alternative mRNA splicing, via spliceosome)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0003676"(nucleic acid binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0016363"(nuclear matrix)|go:"GO:0003723"(RNA binding)|go:"GO:0016607"(nuclear speck)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0042382"(paraspeckles)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042754"(negative regulation of circadian rhythm)|go:"GO:0005634"(nucleus)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045876"(positive regulation of sister chromatid cohesion)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0048511"(rhythmic process)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:0098963"(dendritic transport of messenger ribonucleoprotein complex)|go:"GO:1902177"(positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)|go:"GO:0006355"(regulation of transcription, DNA-templated)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR012975(NOPS)|interpro:IPR034525|interpro:IPR034526|interpro:IPR035979|mint:P23246|rcsb pdb:4WII|rcsb pdb:4WIJ|rcsb pdb:4WIK|rcsb pdb:5WPA|rcsb pdb:6NCQ|rcsb pdb:6OWJ|rcsb pdb:6WMZ|rcsb pdb:7LRQ|rcsb pdb:7LRU|reactome:R-HSA-8849468|reactome:R-HSA-9635465|go:"GO:0006397"(mRNA processing)|go:"GO:0008380"(RNA splicing)|refseq:XP_005271169.1|refseq:XP_005271170.1|refseq:XP_005271172.1|refseq:XP_016857542.1|refseq:XP_016857543.1|dip:DIP-31272N	-	-	-	figure legend:Fig. 5b|causality statement:P23246 decreases expression at RNA level of ENSG00000143819|dataset:Ulcerative colitis - Interactions of proteins identified as having a link to ulcerative colitis|dataset:IBD - Inflammatory bowel disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hep_g2)|taxid:9606("Homo sapiens hepatocellular carcinoma (HCC) cells (p53-wt).")	-	2014/11/30	2014/11/30	-	rogid:B7mSc6tthLbSHo0qz0SMZBSl3HA9606	intact-crc:97A5AD499A4ACBF4	false	binding-associated region:?-?	-	-	-	psi-mi:"MI:0088"(primer specific pcr)	psi-mi:"MI:0088"(primer specific pcr)
uniprotkb:P19793	ensembl:ENSG00000143819	intact:EBI-78598|uniprotkb:Q2V504|uniprotkb:B3KY83|uniprotkb:Q2NL52|ensembl:ENSP00000419692	intact:EBI-9992401	psi-mi:rxra_human(display_long)|uniprotkb:RXRA(gene name)|psi-mi:RXRA(display_short)|uniprotkb:NR2B1(gene name synonym)|uniprotkb:Retinoid X receptor alpha(gene name synonym)|uniprotkb:Nuclear receptor subfamily 2 group B member 1(gene name synonym)	psi-mi:hyep_human_gene(display_short)|psi-mi:ENSG00000143819(display_long)	psi-mi:"MI:0402"(chromatin immunoprecipitation assay)	Peng et al. (2013)	pubmed:23714182|imex:IM-23351	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9992415|imex:IM-23351-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0250"(gene)	refseq:NP_002948.1|refseq:NP_001278850.1|dip:DIP-641N|ensembl:ENSG00000186350(gene)|ensembl:ENST00000481739(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001972"(retinoic acid binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0003707"(steroid hormone receptor activity)|go:"GO:0004879"(nuclear receptor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008203"(cholesterol metabolic process)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010875"(positive regulation of cholesterol efflux)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0019048"(modulation by virus of host process)|go:"GO:0019899"(enzyme binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0032411"(positive regulation of transporter activity)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0035357"(peroxisome proliferator activated receptor signaling pathway)|go:"GO:0042277"(peptide binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0042809"(vitamin D receptor binding)|go:"GO:0043235"(receptor complex)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0044323"(retinoic acid-responsive element binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048384"(retinoic acid receptor signaling pathway)|go:"GO:0048856"(anatomical structure development)|go:"GO:0050692"(DNA binding domain binding)|go:"GO:0050693"(LBD domain binding)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000003(Retinoid X receptor)|interpro:IPR000536(Nuclear hormone receptor, ligand-binding, core)|interpro:IPR001628(Zinc finger, nuclear hormone receptor-type)|interpro:IPR001723(Steroid hormone receptor)|interpro:IPR013088(Zinc finger, NHR/GATA-type)|interpro:IPR021780|interpro:IPR035500|mint:P19793|rcsb pdb:1BY4|rcsb pdb:1DSZ|rcsb pdb:1FBY|rcsb pdb:1FM6|rcsb pdb:1FM9|rcsb pdb:1G1U|rcsb pdb:1G5Y|rcsb pdb:1K74|rcsb pdb:1MV9|rcsb pdb:1MVC|rcsb pdb:1MZN|rcsb pdb:1R0N|rcsb pdb:1RDT|rcsb pdb:1RXR|rcsb pdb:1XLS|rcsb pdb:1XV9|rcsb pdb:1XVP|rcsb pdb:1YNW|rcsb pdb:2ACL|rcsb pdb:2NLL|rcsb pdb:2P1T|rcsb pdb:2P1U|rcsb pdb:2P1V|rcsb pdb:2ZXZ|rcsb pdb:2ZY0|rcsb pdb:3DZU|rcsb pdb:3DZY|rcsb pdb:3E00|rcsb pdb:3E94|rcsb pdb:3FAL|rcsb pdb:3FC6|rcsb pdb:3FUG|rcsb pdb:3H0A|rcsb pdb:3KWY|rcsb pdb:3NSP|rcsb pdb:3NSQ|rcsb pdb:3OAP|rcsb pdb:3OZJ|rcsb pdb:3PCU|rcsb pdb:3R2A|rcsb pdb:3R5M|rcsb pdb:3UVV|rcsb pdb:4CN2|rcsb pdb:4CN3|rcsb pdb:4CN5|rcsb pdb:4CN7|rcsb pdb:4J5W|rcsb pdb:4J5X|rcsb pdb:4K4J|rcsb pdb:4K6I|rcsb pdb:4M8E|rcsb pdb:4M8H|rcsb pdb:4N5G|rcsb pdb:4N8R|rcsb pdb:4NQA|rcsb pdb:4OC7|rcsb pdb:4POH|rcsb pdb:4POJ|rcsb pdb:4PP3|rcsb pdb:4PP5|rcsb pdb:4RFW|rcsb pdb:4RMC|rcsb pdb:4RMD|rcsb pdb:4RME|rcsb pdb:4ZO1|rcsb pdb:4ZSH|rcsb pdb:5EC9|rcsb pdb:5JI0|rcsb pdb:5LYQ|rcsb pdb:5MJ5|rcsb pdb:5MK4|rcsb pdb:5MKJ|rcsb pdb:5MKU|rcsb pdb:5MMW|rcsb pdb:5TBP|rcsb pdb:5UAN|rcsb pdb:5Z12|rcsb pdb:5ZQU|rcsb pdb:6A5Y|rcsb pdb:6A5Z|rcsb pdb:6A60|rcsb pdb:6FBQ|rcsb pdb:6FBR|rcsb pdb:6HN6|rcsb pdb:6JNO|rcsb pdb:6JNR|rcsb pdb:6L6K|rcsb pdb:6LB4|rcsb pdb:6LB5|rcsb pdb:6LB6|rcsb pdb:6SJM|rcsb pdb:6STI|rcsb pdb:6XWG|rcsb pdb:6XWH|rcsb pdb:7A77|rcsb pdb:7B88|rcsb pdb:7B9O|rcsb pdb:7CFO|reactome:R-HSA-1368082|reactome:R-HSA-1368108|reactome:R-HSA-159418|reactome:R-HSA-192105|reactome:R-HSA-193368|reactome:R-HSA-193807|reactome:R-HSA-1989781|reactome:R-HSA-200425|reactome:R-HSA-204174|reactome:R-HSA-211976|reactome:R-HSA-2151201|reactome:R-HSA-2426168|reactome:R-HSA-381340|reactome:R-HSA-383280|reactome:R-HSA-400206|reactome:R-HSA-400253|reactome:R-HSA-4090294|reactome:R-HSA-5362517|reactome:R-HSA-5617472|reactome:R-HSA-9029558|reactome:R-HSA-9029569|reactome:R-HSA-9031525|reactome:R-HSA-9031528|reactome:R-HSA-9616222|reactome:R-HSA-9623433|reactome:R-HSA-9632974|reactome:R-HSA-9707564|reactome:R-HSA-9707616|rcsb pdb:3R29	-	-	-	-	figure legend:Fig. 5b|dataset:Ulcerative colitis - Interactions of proteins identified as having a link to ulcerative colitis|dataset:IBD - Inflammatory bowel disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hep_g2)|taxid:9606("Homo sapiens hepatocellular carcinoma (HCC) cells (p53-wt).")	-	2014/11/30	2014/11/30	rogid:gKnKFur3dYudXOAePzqRZJxqzYQ9606	-	intact-crc:DA1B0C6BB5BEFE6F	false	-	binding-associated region:?-?	-	-	psi-mi:"MI:0088"(primer specific pcr)	psi-mi:"MI:0088"(primer specific pcr)
uniprotkb:P23246	uniprotkb:P41235	intact:EBI-355453|uniprotkb:P30808|uniprotkb:Q5SZ71|ensembl:ENSP00000349748	intact:EBI-1049011|uniprotkb:Q92654|uniprotkb:Q92655|uniprotkb:Q99864|uniprotkb:Q9NQH0|uniprotkb:O00659|uniprotkb:O00723|uniprotkb:Q14540|uniprotkb:Q5QPB8|uniprotkb:Q6B4V5|uniprotkb:Q6B4V6|uniprotkb:Q6B4V7|uniprotkb:Q92653|uniprotkb:A5JW41|uniprotkb:B2RPP8|ensembl:ENSP00000312987	psi-mi:sfpq_human(display_long)|uniprotkb:SFPQ(gene name)|psi-mi:SFPQ(display_short)|uniprotkb:PSF(gene name synonym)|uniprotkb:Polypyrimidine tract-binding protein-associated-splicing factor(gene name synonym)|uniprotkb:DNA-binding p52/p100 complex, 100 kDa subunit(gene name synonym)|uniprotkb:100 kDa DNA-pairing protein(gene name synonym)	psi-mi:hnf4a_human(display_long)|uniprotkb:Transcription factor HNF-4(gene name synonym)|uniprotkb:Nuclear receptor subfamily 2 group A member 1(gene name synonym)|uniprotkb:Transcription factor 14(gene name synonym)|uniprotkb:HNF4A(gene name)|psi-mi:HNF4A(display_short)|uniprotkb:HNF4(gene name synonym)|uniprotkb:NR2A1(gene name synonym)|uniprotkb:TCF14(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Peng et al. (2013)	pubmed:23714182|imex:IM-23351	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9992431|imex:IM-23351-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005057.1|ensembl:ENSG00000116560(gene)|ensembl:ENST00000357214(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000380"(alternative mRNA splicing, via spliceosome)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0003676"(nucleic acid binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0016363"(nuclear matrix)|go:"GO:0003723"(RNA binding)|go:"GO:0016607"(nuclear speck)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0042382"(paraspeckles)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042754"(negative regulation of circadian rhythm)|go:"GO:0005634"(nucleus)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045876"(positive regulation of sister chromatid cohesion)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0048511"(rhythmic process)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:0098963"(dendritic transport of messenger ribonucleoprotein complex)|go:"GO:1902177"(positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)|go:"GO:0006355"(regulation of transcription, DNA-templated)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR012975(NOPS)|interpro:IPR034525|interpro:IPR034526|interpro:IPR035979|mint:P23246|rcsb pdb:4WII|rcsb pdb:4WIJ|rcsb pdb:4WIK|rcsb pdb:5WPA|rcsb pdb:6NCQ|rcsb pdb:6OWJ|rcsb pdb:6WMZ|rcsb pdb:7LRQ|rcsb pdb:7LRU|reactome:R-HSA-8849468|reactome:R-HSA-9635465|go:"GO:0006397"(mRNA processing)|go:"GO:0008380"(RNA splicing)|refseq:XP_005271169.1|refseq:XP_005271170.1|refseq:XP_005271172.1|refseq:XP_016857542.1|refseq:XP_016857543.1|dip:DIP-31272N	refseq:NP_000448.3|refseq:NP_001025174.1|refseq:NP_001025175.1|refseq:NP_787110.2|refseq:NP_849181.1|refseq:NP_001274111.1|refseq:NP_001274112.1|refseq:NP_001274113.1|refseq:NP_001245284.1|ensembl:ENSG00000101076(gene)|ensembl:ENST00000316099(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003323"(type B pancreatic cell development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0004879"(nuclear receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005504"(fatty acid binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006591"(ornithine metabolic process)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0006805"(xenobiotic metabolic process)|go:"GO:0007548"(sex differentiation)|go:"GO:0007596"(blood coagulation)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009749"(response to glucose)|go:"GO:0010470"(regulation of gastrulation)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0023019"(signal transduction involved in regulation of gene expression)|go:"GO:0030154"(cell differentiation)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048511"(rhythmic process)|go:"GO:0048856"(anatomical structure development)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0055088"(lipid homeostasis)|go:"GO:0055091"(phospholipid homeostasis)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0060398"(regulation of growth hormone receptor signaling pathway)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070328"(triglyceride homeostasis)|go:"GO:0070365"(hepatocyte differentiation)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000536(Nuclear hormone receptor, ligand-binding, core)|interpro:IPR001628(Zinc finger, nuclear hormone receptor-type)|interpro:IPR001723(Steroid hormone receptor)|interpro:IPR013088(Zinc finger, NHR/GATA-type)|interpro:IPR035500|interpro:IPR039067|mint:P41235|rcsb pdb:1PZL|rcsb pdb:3CBB|rcsb pdb:3FS1|rcsb pdb:4B7W|rcsb pdb:4IQR|rcsb pdb:6CHT|reactome:R-HSA-210745|reactome:R-HSA-383280|dip:DIP-499N	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig. 5a|dataset:Ulcerative colitis - Interactions of proteins identified as having a link to ulcerative colitis|dataset:IBD - Inflammatory bowel disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hep_g2)|taxid:9606("Homo sapiens hepatocellular carcinoma (HCC) cells (p53-wt).")	-	2014/11/30	2014/12/08	rogid:B7mSc6tthLbSHo0qz0SMZBSl3HA9606	rogid:lul0rM/fHNAVsH3ZizbMOXPPL0k9606	intact-crc:C5EDC304B0F1272A|rigid:DqmjfGWng+PT6mpiaK4WikyDonE	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P23246	uniprotkb:P41235	intact:EBI-355453|uniprotkb:P30808|uniprotkb:Q5SZ71|ensembl:ENSP00000349748	intact:EBI-1049011|uniprotkb:Q92654|uniprotkb:Q92655|uniprotkb:Q99864|uniprotkb:Q9NQH0|uniprotkb:O00659|uniprotkb:O00723|uniprotkb:Q14540|uniprotkb:Q5QPB8|uniprotkb:Q6B4V5|uniprotkb:Q6B4V6|uniprotkb:Q6B4V7|uniprotkb:Q92653|uniprotkb:A5JW41|uniprotkb:B2RPP8|ensembl:ENSP00000312987	psi-mi:sfpq_human(display_long)|uniprotkb:SFPQ(gene name)|psi-mi:SFPQ(display_short)|uniprotkb:PSF(gene name synonym)|uniprotkb:Polypyrimidine tract-binding protein-associated-splicing factor(gene name synonym)|uniprotkb:DNA-binding p52/p100 complex, 100 kDa subunit(gene name synonym)|uniprotkb:100 kDa DNA-pairing protein(gene name synonym)	psi-mi:hnf4a_human(display_long)|uniprotkb:Transcription factor HNF-4(gene name synonym)|uniprotkb:Nuclear receptor subfamily 2 group A member 1(gene name synonym)|uniprotkb:Transcription factor 14(gene name synonym)|uniprotkb:HNF4A(gene name)|psi-mi:HNF4A(display_short)|uniprotkb:HNF4(gene name synonym)|uniprotkb:NR2A1(gene name synonym)|uniprotkb:TCF14(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Peng et al. (2013)	pubmed:23714182|imex:IM-23351	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9992437|imex:IM-23351-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005057.1|ensembl:ENSG00000116560(gene)|ensembl:ENST00000357214(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000380"(alternative mRNA splicing, via spliceosome)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0003676"(nucleic acid binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0016363"(nuclear matrix)|go:"GO:0003723"(RNA binding)|go:"GO:0016607"(nuclear speck)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0042382"(paraspeckles)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042754"(negative regulation of circadian rhythm)|go:"GO:0005634"(nucleus)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045876"(positive regulation of sister chromatid cohesion)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0048511"(rhythmic process)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:0098963"(dendritic transport of messenger ribonucleoprotein complex)|go:"GO:1902177"(positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)|go:"GO:0006355"(regulation of transcription, DNA-templated)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR012975(NOPS)|interpro:IPR034525|interpro:IPR034526|interpro:IPR035979|mint:P23246|rcsb pdb:4WII|rcsb pdb:4WIJ|rcsb pdb:4WIK|rcsb pdb:5WPA|rcsb pdb:6NCQ|rcsb pdb:6OWJ|rcsb pdb:6WMZ|rcsb pdb:7LRQ|rcsb pdb:7LRU|reactome:R-HSA-8849468|reactome:R-HSA-9635465|go:"GO:0006397"(mRNA processing)|go:"GO:0008380"(RNA splicing)|refseq:XP_005271169.1|refseq:XP_005271170.1|refseq:XP_005271172.1|refseq:XP_016857542.1|refseq:XP_016857543.1|dip:DIP-31272N	refseq:NP_000448.3|refseq:NP_001025174.1|refseq:NP_001025175.1|refseq:NP_787110.2|refseq:NP_849181.1|refseq:NP_001274111.1|refseq:NP_001274112.1|refseq:NP_001274113.1|refseq:NP_001245284.1|ensembl:ENSG00000101076(gene)|ensembl:ENST00000316099(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003323"(type B pancreatic cell development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0004879"(nuclear receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005504"(fatty acid binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006591"(ornithine metabolic process)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0006805"(xenobiotic metabolic process)|go:"GO:0007548"(sex differentiation)|go:"GO:0007596"(blood coagulation)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009749"(response to glucose)|go:"GO:0010470"(regulation of gastrulation)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0023019"(signal transduction involved in regulation of gene expression)|go:"GO:0030154"(cell differentiation)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048511"(rhythmic process)|go:"GO:0048856"(anatomical structure development)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0055088"(lipid homeostasis)|go:"GO:0055091"(phospholipid homeostasis)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0060398"(regulation of growth hormone receptor signaling pathway)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070328"(triglyceride homeostasis)|go:"GO:0070365"(hepatocyte differentiation)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000536(Nuclear hormone receptor, ligand-binding, core)|interpro:IPR001628(Zinc finger, nuclear hormone receptor-type)|interpro:IPR001723(Steroid hormone receptor)|interpro:IPR013088(Zinc finger, NHR/GATA-type)|interpro:IPR035500|interpro:IPR039067|mint:P41235|rcsb pdb:1PZL|rcsb pdb:3CBB|rcsb pdb:3FS1|rcsb pdb:4B7W|rcsb pdb:4IQR|rcsb pdb:6CHT|reactome:R-HSA-210745|reactome:R-HSA-383280|dip:DIP-499N	go:"GO:0005634"(nucleus)	-	-	figure legend:Fig. 5a|dataset:Ulcerative colitis - Interactions of proteins identified as having a link to ulcerative colitis|dataset:IBD - Inflammatory bowel disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hep_g2)|taxid:9606("Homo sapiens hepatocellular carcinoma (HCC) cells (p53-wt).")	-	2014/11/30	2014/12/08	rogid:B7mSc6tthLbSHo0qz0SMZBSl3HA9606	rogid:lul0rM/fHNAVsH3ZizbMOXPPL0k9606	intact-crc:FCCFA78546561F13|rigid:DqmjfGWng+PT6mpiaK4WikyDonE	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P41235	intact:EBI-9992455	intact:EBI-1049011|uniprotkb:Q92654|uniprotkb:Q92655|uniprotkb:Q99864|uniprotkb:Q9NQH0|uniprotkb:O00659|uniprotkb:O00723|uniprotkb:Q14540|uniprotkb:Q5QPB8|uniprotkb:Q6B4V5|uniprotkb:Q6B4V6|uniprotkb:Q6B4V7|uniprotkb:Q92653|uniprotkb:A5JW41|uniprotkb:B2RPP8|ensembl:ENSP00000312987	-	psi-mi:hnf4a_human(display_long)|uniprotkb:Transcription factor HNF-4(gene name synonym)|uniprotkb:Nuclear receptor subfamily 2 group A member 1(gene name synonym)|uniprotkb:Transcription factor 14(gene name synonym)|uniprotkb:HNF4A(gene name)|psi-mi:HNF4A(display_short)|uniprotkb:HNF4(gene name synonym)|uniprotkb:NR2A1(gene name synonym)|uniprotkb:TCF14(gene name synonym)	psi-mi:hyep_human_hnf4a-site_dna-probe(display_short)|psi-mi:EBI-9992455(display_long)	psi-mi:"MI:0412"(electrophoretic mobility supershift assay)	Peng et al. (2013)	pubmed:23714182|imex:IM-23351	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9992458|imex:IM-23351-6	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0319"(deoxyribonucleic acid)	refseq:NP_000448.3|refseq:NP_001025174.1|refseq:NP_001025175.1|refseq:NP_787110.2|refseq:NP_849181.1|refseq:NP_001274111.1|refseq:NP_001274112.1|refseq:NP_001274113.1|refseq:NP_001245284.1|ensembl:ENSG00000101076(gene)|ensembl:ENST00000316099(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003323"(type B pancreatic cell development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0004879"(nuclear receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005504"(fatty acid binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006591"(ornithine metabolic process)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0006805"(xenobiotic metabolic process)|go:"GO:0007548"(sex differentiation)|go:"GO:0007596"(blood coagulation)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009749"(response to glucose)|go:"GO:0010470"(regulation of gastrulation)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0023019"(signal transduction involved in regulation of gene expression)|go:"GO:0030154"(cell differentiation)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048511"(rhythmic process)|go:"GO:0048856"(anatomical structure development)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0055088"(lipid homeostasis)|go:"GO:0055091"(phospholipid homeostasis)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0060398"(regulation of growth hormone receptor signaling pathway)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070328"(triglyceride homeostasis)|go:"GO:0070365"(hepatocyte differentiation)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000536(Nuclear hormone receptor, ligand-binding, core)|interpro:IPR001628(Zinc finger, nuclear hormone receptor-type)|interpro:IPR001723(Steroid hormone receptor)|interpro:IPR013088(Zinc finger, NHR/GATA-type)|interpro:IPR035500|interpro:IPR039067|mint:P41235|rcsb pdb:1PZL|rcsb pdb:3CBB|rcsb pdb:3FS1|rcsb pdb:4B7W|rcsb pdb:4IQR|rcsb pdb:6CHT|reactome:R-HSA-210745|reactome:R-HSA-383280|dip:DIP-499N	ensembl:ENSG00000143819(see-also)	-	-	-	figure legend:Fig. 1f|dataset:Ulcerative colitis - Interactions of proteins identified as having a link to ulcerative colitis|dataset:IBD - Inflammatory bowel disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/11/30	2014/11/30	rogid:lul0rM/fHNAVsH3ZizbMOXPPL0k9606	-	intact-crc:C38E153C2E7317CF	false	-	32p radiolabel:?-?|mutation disrupting interaction:12-12,14-16	-	-	psi-mi:"MI:0833"(autoradiography)	psi-mi:"MI:0833"(autoradiography)
intact:EBI-9992455	uniprotkb:P41235	-	intact:EBI-1049011|uniprotkb:Q92654|uniprotkb:Q92655|uniprotkb:Q99864|uniprotkb:Q9NQH0|uniprotkb:O00659|uniprotkb:O00723|uniprotkb:Q14540|uniprotkb:Q5QPB8|uniprotkb:Q6B4V5|uniprotkb:Q6B4V6|uniprotkb:Q6B4V7|uniprotkb:Q92653|uniprotkb:A5JW41|uniprotkb:B2RPP8|ensembl:ENSP00000312987	psi-mi:hyep_human_hnf4a-site_dna-probe(display_short)|psi-mi:EBI-9992455(display_long)	psi-mi:hnf4a_human(display_long)|uniprotkb:Transcription factor HNF-4(gene name synonym)|uniprotkb:Nuclear receptor subfamily 2 group A member 1(gene name synonym)|uniprotkb:Transcription factor 14(gene name synonym)|uniprotkb:HNF4A(gene name)|psi-mi:HNF4A(display_short)|uniprotkb:HNF4(gene name synonym)|uniprotkb:NR2A1(gene name synonym)|uniprotkb:TCF14(gene name synonym)	psi-mi:"MI:0412"(electrophoretic mobility supershift assay)	Peng et al. (2013)	pubmed:23714182|imex:IM-23351	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9992466|imex:IM-23351-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0319"(deoxyribonucleic acid)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000143819(see-also)	refseq:NP_000448.3|refseq:NP_001025174.1|refseq:NP_001025175.1|refseq:NP_787110.2|refseq:NP_849181.1|refseq:NP_001274111.1|refseq:NP_001274112.1|refseq:NP_001274113.1|refseq:NP_001245284.1|ensembl:ENSG00000101076(gene)|ensembl:ENST00000316099(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003323"(type B pancreatic cell development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0004879"(nuclear receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005504"(fatty acid binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006591"(ornithine metabolic process)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0006805"(xenobiotic metabolic process)|go:"GO:0007548"(sex differentiation)|go:"GO:0007596"(blood coagulation)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009749"(response to glucose)|go:"GO:0010470"(regulation of gastrulation)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0023019"(signal transduction involved in regulation of gene expression)|go:"GO:0030154"(cell differentiation)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048511"(rhythmic process)|go:"GO:0048856"(anatomical structure development)|go:"GO:0050796"(regulation of insulin secretion)|go:"GO:0055088"(lipid homeostasis)|go:"GO:0055091"(phospholipid homeostasis)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0060398"(regulation of growth hormone receptor signaling pathway)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070328"(triglyceride homeostasis)|go:"GO:0070365"(hepatocyte differentiation)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000536(Nuclear hormone receptor, ligand-binding, core)|interpro:IPR001628(Zinc finger, nuclear hormone receptor-type)|interpro:IPR001723(Steroid hormone receptor)|interpro:IPR013088(Zinc finger, NHR/GATA-type)|interpro:IPR035500|interpro:IPR039067|mint:P41235|rcsb pdb:1PZL|rcsb pdb:3CBB|rcsb pdb:3FS1|rcsb pdb:4B7W|rcsb pdb:4IQR|rcsb pdb:6CHT|reactome:R-HSA-210745|reactome:R-HSA-383280|dip:DIP-499N	-	-	-	figure legend:Fig. 1f|dataset:Ulcerative colitis - Interactions of proteins identified as having a link to ulcerative colitis|dataset:IBD - Inflammatory bowel disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/11/30	2014/11/30	-	rogid:lul0rM/fHNAVsH3ZizbMOXPPL0k9606	intact-crc:7E88261891DD37DE	false	32p radiolabel:?-?	-	-	-	psi-mi:"MI:0833"(autoradiography)	psi-mi:"MI:0833"(autoradiography)
intact:EBI-9992455	intact:EBI-9992455	-	-	psi-mi:hyep_human_hnf4a-site_dna-probe(display_short)|psi-mi:EBI-9992455(display_long)	psi-mi:hyep_human_hnf4a-site_dna-probe(display_short)|psi-mi:EBI-9992455(display_long)	psi-mi:"MI:0412"(electrophoretic mobility supershift assay)	Peng et al. (2013)	pubmed:23714182|imex:IM-23351	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9992466|imex:IM-23351-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0941"(competitor)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0319"(deoxyribonucleic acid)	psi-mi:"MI:0319"(deoxyribonucleic acid)	ensembl:ENSG00000143819(see-also)	ensembl:ENSG00000143819(see-also)	-	-	-	figure legend:Fig. 1f|dataset:Ulcerative colitis - Interactions of proteins identified as having a link to ulcerative colitis|dataset:IBD - Inflammatory bowel disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/11/30	2014/11/30	-	-	intact-crc:7E88261891DD37DE	false	32p radiolabel:?-?	mutation disrupting interaction:12-12,14-16	-	-	psi-mi:"MI:0833"(autoradiography)	psi-mi:"MI:0833"(autoradiography)
uniprotkb:Q14994	intact:EBI-9992475	intact:EBI-960794|uniprotkb:E9PB75|uniprotkb:E9PC13|uniprotkb:E9PDU3|uniprotkb:E9PHC8|uniprotkb:Q6GZ76|uniprotkb:Q6GZ79|uniprotkb:Q6GZ82|uniprotkb:Q6GZ89|uniprotkb:E9PGH6|uniprotkb:E9PH10|uniprotkb:Q5VTW5|uniprotkb:Q5VTW6|uniprotkb:E9PHN4|uniprotkb:Q6GZ77|uniprotkb:Q6GZ78|uniprotkb:Q6GZ83|uniprotkb:F1D8Q0|uniprotkb:F1D8Q1|uniprotkb:Q0VAC9|uniprotkb:Q6GZ68|uniprotkb:Q6GZ84|uniprotkb:Q6GZ87|uniprotkb:Q6GZ85|uniprotkb:Q4U0F0|ensembl:ENSP00000356961	-	psi-mi:nr1i3_human(display_long)|uniprotkb:NR1I3(gene name)|psi-mi:NR1I3(display_short)|uniprotkb:CAR(gene name synonym)|uniprotkb:Constitutive androstane receptor(gene name synonym)|uniprotkb:Constitutive activator of retinoid response(gene name synonym)|uniprotkb:Orphan nuclear receptor MB67(gene name synonym)	psi-mi:hyep_human_car-site_dna-probe(display_short)|psi-mi:EBI-9992475(display_long)	psi-mi:"MI:0412"(electrophoretic mobility supershift assay)	Peng et al. (2013)	pubmed:23714182|imex:IM-23351	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9992478|imex:IM-23351-8	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0319"(deoxyribonucleic acid)	refseq:NP_001070941.1|refseq:NP_001070944.1|refseq:NP_001070945.1|refseq:NP_001070948.1|refseq:NP_005113.1|refseq:NP_001070937.1|refseq:NP_001070942.1|refseq:NP_001070943.1|refseq:NP_001070946.1|refseq:NP_001070938.1|refseq:NP_001070940.1|refseq:NP_001070947.1|refseq:NP_001070949.1|refseq:NP_001070950.1|refseq:NP_001070939.1|ensembl:ENSG00000143257(gene)|ensembl:ENST00000367982(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0004879"(nuclear receptor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0007165"(signal transduction)|go:"GO:0008270"(zinc ion binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000536(Nuclear hormone receptor, ligand-binding, core)|interpro:IPR001628(Zinc finger, nuclear hormone receptor-type)|interpro:IPR001723(Steroid hormone receptor)|interpro:IPR001728(Thyroid hormone receptor)|interpro:IPR013088(Zinc finger, NHR/GATA-type)|interpro:IPR035500|rcsb pdb:1XV9|rcsb pdb:1XVP|reactome:R-HSA-383280	ensembl:ENSG00000143819(see-also)	-	-	-	figure legend:Fig. 3f|causality statement:Q14994 increases expression at RNA level of ENSG00000143819|dataset:Ulcerative colitis - Interactions of proteins identified as having a link to ulcerative colitis|dataset:IBD - Inflammatory bowel disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/11/30	2014/11/30	rogid:O7jzKsV+T6ebbQQTaZq0xYiqls89606	-	intact-crc:8402D6797754EC0E	false	-	32p radiolabel:?-?|mutation disrupting interaction:8-10	-	-	psi-mi:"MI:0833"(autoradiography)	psi-mi:"MI:0833"(autoradiography)
intact:EBI-9992475	uniprotkb:Q14994	-	intact:EBI-960794|uniprotkb:E9PB75|uniprotkb:E9PC13|uniprotkb:E9PDU3|uniprotkb:E9PHC8|uniprotkb:Q6GZ76|uniprotkb:Q6GZ79|uniprotkb:Q6GZ82|uniprotkb:Q6GZ89|uniprotkb:E9PGH6|uniprotkb:E9PH10|uniprotkb:Q5VTW5|uniprotkb:Q5VTW6|uniprotkb:E9PHN4|uniprotkb:Q6GZ77|uniprotkb:Q6GZ78|uniprotkb:Q6GZ83|uniprotkb:F1D8Q0|uniprotkb:F1D8Q1|uniprotkb:Q0VAC9|uniprotkb:Q6GZ68|uniprotkb:Q6GZ84|uniprotkb:Q6GZ87|uniprotkb:Q6GZ85|uniprotkb:Q4U0F0|ensembl:ENSP00000356961	psi-mi:hyep_human_car-site_dna-probe(display_short)|psi-mi:EBI-9992475(display_long)	psi-mi:nr1i3_human(display_long)|uniprotkb:NR1I3(gene name)|psi-mi:NR1I3(display_short)|uniprotkb:CAR(gene name synonym)|uniprotkb:Constitutive androstane receptor(gene name synonym)|uniprotkb:Constitutive activator of retinoid response(gene name synonym)|uniprotkb:Orphan nuclear receptor MB67(gene name synonym)	psi-mi:"MI:0412"(electrophoretic mobility supershift assay)	Peng et al. (2013)	pubmed:23714182|imex:IM-23351	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9992486|imex:IM-23351-9	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0319"(deoxyribonucleic acid)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000143819(see-also)	refseq:NP_001070941.1|refseq:NP_001070944.1|refseq:NP_001070945.1|refseq:NP_001070948.1|refseq:NP_005113.1|refseq:NP_001070937.1|refseq:NP_001070942.1|refseq:NP_001070943.1|refseq:NP_001070946.1|refseq:NP_001070938.1|refseq:NP_001070940.1|refseq:NP_001070947.1|refseq:NP_001070949.1|refseq:NP_001070950.1|refseq:NP_001070939.1|ensembl:ENSG00000143257(gene)|ensembl:ENST00000367982(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0004879"(nuclear receptor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0007165"(signal transduction)|go:"GO:0008270"(zinc ion binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000536(Nuclear hormone receptor, ligand-binding, core)|interpro:IPR001628(Zinc finger, nuclear hormone receptor-type)|interpro:IPR001723(Steroid hormone receptor)|interpro:IPR001728(Thyroid hormone receptor)|interpro:IPR013088(Zinc finger, NHR/GATA-type)|interpro:IPR035500|rcsb pdb:1XV9|rcsb pdb:1XVP|reactome:R-HSA-383280	-	-	-	figure legend:Fig. 3f|comment:Competition was seen to the  middle and upper bands of the complex but not the lower band.|dataset:Ulcerative colitis - Interactions of proteins identified as having a link to ulcerative colitis|dataset:IBD - Inflammatory bowel disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/11/30	2014/12/04	-	rogid:O7jzKsV+T6ebbQQTaZq0xYiqls89606	intact-crc:77919E5F9F30B02F	false	32p radiolabel:?-?	-	-	-	psi-mi:"MI:0833"(autoradiography)	psi-mi:"MI:0833"(autoradiography)
intact:EBI-9992475	intact:EBI-9992475	-	-	psi-mi:hyep_human_car-site_dna-probe(display_short)|psi-mi:EBI-9992475(display_long)	psi-mi:hyep_human_car-site_dna-probe(display_short)|psi-mi:EBI-9992475(display_long)	psi-mi:"MI:0412"(electrophoretic mobility supershift assay)	Peng et al. (2013)	pubmed:23714182|imex:IM-23351	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9992486|imex:IM-23351-9	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0941"(competitor)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0319"(deoxyribonucleic acid)	psi-mi:"MI:0319"(deoxyribonucleic acid)	ensembl:ENSG00000143819(see-also)	ensembl:ENSG00000143819(see-also)	-	-	-	figure legend:Fig. 3f|comment:Competition was seen to the  middle and upper bands of the complex but not the lower band.|dataset:Ulcerative colitis - Interactions of proteins identified as having a link to ulcerative colitis|dataset:IBD - Inflammatory bowel disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/11/30	2014/12/04	-	-	intact-crc:77919E5F9F30B02F	false	32p radiolabel:?-?	mutation disrupting interaction:8-10	-	-	psi-mi:"MI:0833"(autoradiography)	psi-mi:"MI:0833"(autoradiography)
intact:EBI-9992512	uniprotkb:P23246	-	intact:EBI-355453|uniprotkb:P30808|uniprotkb:Q5SZ71|ensembl:ENSP00000349748	psi-mi:hyep_human_car+hnf4a-site_dna-probe(display_short)|psi-mi:EBI-9992512(display_long)	psi-mi:sfpq_human(display_long)|uniprotkb:SFPQ(gene name)|psi-mi:SFPQ(display_short)|uniprotkb:PSF(gene name synonym)|uniprotkb:Polypyrimidine tract-binding protein-associated-splicing factor(gene name synonym)|uniprotkb:DNA-binding p52/p100 complex, 100 kDa subunit(gene name synonym)|uniprotkb:100 kDa DNA-pairing protein(gene name synonym)	psi-mi:"MI:0096"(pull down)	Peng et al. (2013)	pubmed:23714182|imex:IM-23351	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9992515|imex:IM-23351-10	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0319"(deoxyribonucleic acid)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000143819(see-also)	refseq:NP_005057.1|ensembl:ENSG00000116560(gene)|ensembl:ENST00000357214(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000380"(alternative mRNA splicing, via spliceosome)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0003676"(nucleic acid binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0016363"(nuclear matrix)|go:"GO:0003723"(RNA binding)|go:"GO:0016607"(nuclear speck)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0042382"(paraspeckles)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042754"(negative regulation of circadian rhythm)|go:"GO:0005634"(nucleus)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045876"(positive regulation of sister chromatid cohesion)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0048511"(rhythmic process)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:0098963"(dendritic transport of messenger ribonucleoprotein complex)|go:"GO:1902177"(positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)|go:"GO:0006355"(regulation of transcription, DNA-templated)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR012975(NOPS)|interpro:IPR034525|interpro:IPR034526|interpro:IPR035979|mint:P23246|rcsb pdb:4WII|rcsb pdb:4WIJ|rcsb pdb:4WIK|rcsb pdb:5WPA|rcsb pdb:6NCQ|rcsb pdb:6OWJ|rcsb pdb:6WMZ|rcsb pdb:7LRQ|rcsb pdb:7LRU|reactome:R-HSA-8849468|reactome:R-HSA-9635465|go:"GO:0006397"(mRNA processing)|go:"GO:0008380"(RNA splicing)|refseq:XP_005271169.1|refseq:XP_005271170.1|refseq:XP_005271172.1|refseq:XP_016857542.1|refseq:XP_016857543.1|dip:DIP-31272N	-	-	-	figure legend:none|dataset:Ulcerative colitis - Interactions of proteins identified as having a link to ulcerative colitis|dataset:IBD - Inflammatory bowel disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/11/30	2014/12/05	-	rogid:B7mSc6tthLbSHo0qz0SMZBSl3HA9606	intact-crc:61FC2989D5E6C362	false	biotin tag:?-?	-	-	-	psi-mi:"MI:0427"(Identification by mass spectrometry)	psi-mi:"MI:0427"(Identification by mass spectrometry)