#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q99081	uniprotkb:O75593	intact:EBI-722877|uniprotkb:Q86VM2|ensembl:ENSP00000267811|ensembl:ENSP00000453737|uniprotkb:Q7Z3D9|uniprotkb:Q86TC1|uniprotkb:B4E1W1	intact:EBI-1759806|uniprotkb:D3DWM4|ensembl:ENSP00000366534	psi-mi:htf4_human(display_long)|uniprotkb:Transcription factor HTF-4(gene name synonym)|uniprotkb:E-box-binding protein(gene name synonym)|uniprotkb:DNA-binding protein HTF4(gene name synonym)|uniprotkb:TCF12(gene name)|psi-mi:TCF12(display_short)|uniprotkb:HEB(gene name synonym)|uniprotkb:HTF4(gene name synonym)|uniprotkb:BHLHB20(gene name synonym)|uniprotkb:Class B basic helix-loop-helix protein 20(gene name synonym)	psi-mi:foxh1_human(display_long)|uniprotkb:FOXH1(gene name)|psi-mi:FOXH1(display_short)|uniprotkb:FAST1(gene name synonym)|uniprotkb:FAST2(gene name synonym)|uniprotkb:Forkhead activin signal transducer 1(gene name synonym)|uniprotkb:Forkhead activin signal transducer 2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Yoon et al. (2011)	pubmed:21828274|imex:IM-22642	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-9542697|imex:IM-22642-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001309086.1|refseq:NP_003196.1|refseq:NP_996919.1|refseq:NP_996920.1|refseq:NP_996921.1|refseq:NP_996923.1|ensembl:ENSG00000140262(gene)|ensembl:ENST00000267811(transcript)|ensembl:ENST00000557843(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006955"(immune response)|go:"GO:0007399"(nervous system development)|go:"GO:0007517"(muscle organ development)|go:"GO:0008134"(transcription factor binding)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016607"(nuclear speck)|go:"GO:0030154"(cell differentiation)|go:"GO:0035497"(cAMP response element binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043425"(bHLH transcription factor binding)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046332"(SMAD binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0070888"(E-box binding)|go:"GO:0071837"(HMG box domain binding)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR036638|refseq:NP_001309080.1|refseq:NP_001293149.1|refseq:NP_001309088.1|refseq:NP_001309091.1|refseq:NP_001309094.1|dip:DIP-29403N|mint:Q99081|rcsb pdb:2KNH|rcsb pdb:4JOL|reactome:R-HSA-525793|reactome:R-HSA-8939236|reactome:R-HSA-9031628	refseq:NP_003914.1|ensembl:ENSG00000160973(gene)|ensembl:ENST00000377317(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001947"(heart looping)|go:"GO:0003139"(secondary heart field specification)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0003215"(cardiac right ventricle morphogenesis)|go:"GO:0003222"(ventricular trabecula myocardium morphogenesis)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0032444"(activin responsive factor complex)|go:"GO:0033147"(negative regulation of intracellular estrogen receptor signaling pathway)|go:"GO:0035054"(embryonic heart tube anterior/posterior pattern specification)|go:"GO:0035909"(aorta morphogenesis)|go:"GO:0043425"(bHLH transcription factor binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046332"(SMAD binding)|go:"GO:0048318"(axial mesoderm development)|go:"GO:0050681"(androgen receptor binding)|go:"GO:0060766"(negative regulation of androgen receptor signaling pathway)|go:"GO:0070410"(co-SMAD binding)|go:"GO:0070412"(R-SMAD binding)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:1900164"(nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry)|interpro:IPR001766(Fork head transcription factor)|interpro:IPR030456|interpro:IPR036388|interpro:IPR036390|rcsb pdb:5XOC|reactome:R-HSA-1181150|reactome:R-HSA-1502540	-	-	-	figure legend:Fig 2C|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-endoerm)|taxid:9606(Human endoderm)	-	2014/05/30	2014/10/16	rogid:XnBrmDaoz2JZQ66PCjfJsmaQ6209606	rogid:uZzViiPJyxYi9PHrgIEN/ZBW5tI9606	intact-crc:A352B15424E91512|rigid:uD5lvNGSv1DiNM1gY602vsERixw	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P15923	uniprotkb:O75593	intact:EBI-769630|uniprotkb:Q2TB40|uniprotkb:P15883|uniprotkb:Q14208|uniprotkb:Q14635|uniprotkb:Q14636|uniprotkb:Q9UPI9|uniprotkb:Q2TB39|intact:EBI-11119608|ensembl:ENSP00000262965	intact:EBI-1759806|uniprotkb:D3DWM4|ensembl:ENSP00000366534	psi-mi:tfe2_human(display_long)|uniprotkb:Immunoglobulin enhancer-binding factor E12/E47(gene name synonym)|uniprotkb:Transcription factor 3(gene name synonym)|uniprotkb:Immunoglobulin transcription factor 1(gene name synonym)|uniprotkb:Transcription factor ITF-1(gene name synonym)|uniprotkb:Kappa-E2-binding factor(gene name synonym)|uniprotkb:TCF3(gene name)|psi-mi:TCF3(display_short)|uniprotkb:E2A(gene name synonym)|uniprotkb:ITF1(gene name synonym)|uniprotkb:BHLHB21(gene name synonym)|uniprotkb:Class B basic helix-loop-helix protein 21(gene name synonym)	psi-mi:foxh1_human(display_long)|uniprotkb:FOXH1(gene name)|psi-mi:FOXH1(display_short)|uniprotkb:FAST1(gene name synonym)|uniprotkb:FAST2(gene name synonym)|uniprotkb:Forkhead activin signal transducer 1(gene name synonym)|uniprotkb:Forkhead activin signal transducer 2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Yoon et al. (2011)	pubmed:21828274|imex:IM-22642	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-9542695|imex:IM-22642-6	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001129611.1|refseq:NP_003191.1|refseq:XP_016882669.1|refseq:XP_016882670.1|refseq:XP_016882671.1|dip:DIP-74N|go:"GO:0000785"(chromatin)|go:"GO:0000791"(euchromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|ensembl:ENSG00000071564(gene)|ensembl:ENST00000262965(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0002326"(B cell lineage commitment)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007399"(nervous system development)|go:"GO:0008134"(transcription factor binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0031435"(mitogen-activated protein kinase kinase kinase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033152"("immunoglobulin V(D)J recombination")|go:"GO:0042803"(protein homodimerization activity)|rcsb pdb:2YPA|rcsb pdb:2YPB|rcsb pdb:3U5V|rcsb pdb:6MGN|reactome:R-HSA-525793|reactome:R-HSA-8939236|rcsb pdb:2MH0|go:"GO:0043425"(bHLH transcription factor binding)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045787"(positive regulation of cell cycle)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070644"(vitamin D response element binding)|go:"GO:0070888"(E-box binding)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000045"(regulation of G1/S transition of mitotic cell cycle)|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR036638|rcsb pdb:1HLH	refseq:NP_003914.1|ensembl:ENSG00000160973(gene)|ensembl:ENST00000377317(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001947"(heart looping)|go:"GO:0003139"(secondary heart field specification)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0003215"(cardiac right ventricle morphogenesis)|go:"GO:0003222"(ventricular trabecula myocardium morphogenesis)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0032444"(activin responsive factor complex)|go:"GO:0033147"(negative regulation of intracellular estrogen receptor signaling pathway)|go:"GO:0035054"(embryonic heart tube anterior/posterior pattern specification)|go:"GO:0035909"(aorta morphogenesis)|go:"GO:0043425"(bHLH transcription factor binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046332"(SMAD binding)|go:"GO:0048318"(axial mesoderm development)|go:"GO:0050681"(androgen receptor binding)|go:"GO:0060766"(negative regulation of androgen receptor signaling pathway)|go:"GO:0070410"(co-SMAD binding)|go:"GO:0070412"(R-SMAD binding)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:1900164"(nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry)|interpro:IPR001766(Fork head transcription factor)|interpro:IPR030456|interpro:IPR036388|interpro:IPR036390|rcsb pdb:5XOC|reactome:R-HSA-1181150|reactome:R-HSA-1502540	-	-	-	figure legend:Fig 2C|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-endoerm)|taxid:9606(Human endoderm)	-	2014/05/30	2014/10/16	rogid:EybpTkEZM4cIWyf25UVHfaOaP3Y9606	rogid:uZzViiPJyxYi9PHrgIEN/ZBW5tI9606	intact-crc:9937CDE5217870EB|rigid:PCtNekxs10Z1HBNRdYrEvgCKmtQ	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q99081	uniprotkb:O75593	intact:EBI-722877|uniprotkb:Q86VM2|ensembl:ENSP00000267811|ensembl:ENSP00000453737|uniprotkb:Q7Z3D9|uniprotkb:Q86TC1|uniprotkb:B4E1W1	intact:EBI-1759806|uniprotkb:D3DWM4|ensembl:ENSP00000366534	psi-mi:htf4_human(display_long)|uniprotkb:Transcription factor HTF-4(gene name synonym)|uniprotkb:E-box-binding protein(gene name synonym)|uniprotkb:DNA-binding protein HTF4(gene name synonym)|uniprotkb:TCF12(gene name)|psi-mi:TCF12(display_short)|uniprotkb:HEB(gene name synonym)|uniprotkb:HTF4(gene name synonym)|uniprotkb:BHLHB20(gene name synonym)|uniprotkb:Class B basic helix-loop-helix protein 20(gene name synonym)	psi-mi:foxh1_human(display_long)|uniprotkb:FOXH1(gene name)|psi-mi:FOXH1(display_short)|uniprotkb:FAST1(gene name synonym)|uniprotkb:FAST2(gene name synonym)|uniprotkb:Forkhead activin signal transducer 1(gene name synonym)|uniprotkb:Forkhead activin signal transducer 2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Yoon et al. (2011)	pubmed:21828274|imex:IM-22642	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-9542673|imex:IM-22642-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001309086.1|refseq:NP_003196.1|refseq:NP_996919.1|refseq:NP_996920.1|refseq:NP_996921.1|refseq:NP_996923.1|ensembl:ENSG00000140262(gene)|ensembl:ENST00000267811(transcript)|ensembl:ENST00000557843(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006955"(immune response)|go:"GO:0007399"(nervous system development)|go:"GO:0007517"(muscle organ development)|go:"GO:0008134"(transcription factor binding)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016607"(nuclear speck)|go:"GO:0030154"(cell differentiation)|go:"GO:0035497"(cAMP response element binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043425"(bHLH transcription factor binding)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046332"(SMAD binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0070888"(E-box binding)|go:"GO:0071837"(HMG box domain binding)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR036638|refseq:NP_001309080.1|refseq:NP_001293149.1|refseq:NP_001309088.1|refseq:NP_001309091.1|refseq:NP_001309094.1|dip:DIP-29403N|mint:Q99081|rcsb pdb:2KNH|rcsb pdb:4JOL|reactome:R-HSA-525793|reactome:R-HSA-8939236|reactome:R-HSA-9031628	refseq:NP_003914.1|ensembl:ENSG00000160973(gene)|ensembl:ENST00000377317(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001947"(heart looping)|go:"GO:0003139"(secondary heart field specification)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0003215"(cardiac right ventricle morphogenesis)|go:"GO:0003222"(ventricular trabecula myocardium morphogenesis)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0032444"(activin responsive factor complex)|go:"GO:0033147"(negative regulation of intracellular estrogen receptor signaling pathway)|go:"GO:0035054"(embryonic heart tube anterior/posterior pattern specification)|go:"GO:0035909"(aorta morphogenesis)|go:"GO:0043425"(bHLH transcription factor binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046332"(SMAD binding)|go:"GO:0048318"(axial mesoderm development)|go:"GO:0050681"(androgen receptor binding)|go:"GO:0060766"(negative regulation of androgen receptor signaling pathway)|go:"GO:0070410"(co-SMAD binding)|go:"GO:0070412"(R-SMAD binding)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:1900164"(nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry)|interpro:IPR001766(Fork head transcription factor)|interpro:IPR030456|interpro:IPR036388|interpro:IPR036390|rcsb pdb:5XOC|reactome:R-HSA-1181150|reactome:R-HSA-1502540	-	-	-	figure legend:Fig 2C|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-embryonic_stem_ cells)|taxid:9606("Human-embryonic_stem_ cells (es cells)")	-	2014/05/30	2014/10/16	rogid:XnBrmDaoz2JZQ66PCjfJsmaQ6209606	rogid:uZzViiPJyxYi9PHrgIEN/ZBW5tI9606	intact-crc:87C984F705231D75|rigid:uD5lvNGSv1DiNM1gY602vsERixw	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q99081	uniprotkb:P15923	intact:EBI-722877|uniprotkb:Q86VM2|ensembl:ENSP00000267811|ensembl:ENSP00000453737|uniprotkb:Q7Z3D9|uniprotkb:Q86TC1|uniprotkb:B4E1W1	intact:EBI-769630|uniprotkb:Q2TB40|uniprotkb:P15883|uniprotkb:Q14208|uniprotkb:Q14635|uniprotkb:Q14636|uniprotkb:Q9UPI9|uniprotkb:Q2TB39|intact:EBI-11119608|ensembl:ENSP00000262965	psi-mi:htf4_human(display_long)|uniprotkb:Transcription factor HTF-4(gene name synonym)|uniprotkb:E-box-binding protein(gene name synonym)|uniprotkb:DNA-binding protein HTF4(gene name synonym)|uniprotkb:TCF12(gene name)|psi-mi:TCF12(display_short)|uniprotkb:HEB(gene name synonym)|uniprotkb:HTF4(gene name synonym)|uniprotkb:BHLHB20(gene name synonym)|uniprotkb:Class B basic helix-loop-helix protein 20(gene name synonym)	psi-mi:tfe2_human(display_long)|uniprotkb:Immunoglobulin enhancer-binding factor E12/E47(gene name synonym)|uniprotkb:Transcription factor 3(gene name synonym)|uniprotkb:Immunoglobulin transcription factor 1(gene name synonym)|uniprotkb:Transcription factor ITF-1(gene name synonym)|uniprotkb:Kappa-E2-binding factor(gene name synonym)|uniprotkb:TCF3(gene name)|psi-mi:TCF3(display_short)|uniprotkb:E2A(gene name synonym)|uniprotkb:ITF1(gene name synonym)|uniprotkb:BHLHB21(gene name synonym)|uniprotkb:Class B basic helix-loop-helix protein 21(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Yoon et al. (2011)	pubmed:21828274|imex:IM-22642	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-9542660|imex:IM-22642-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001309086.1|refseq:NP_003196.1|refseq:NP_996919.1|refseq:NP_996920.1|refseq:NP_996921.1|refseq:NP_996923.1|ensembl:ENSG00000140262(gene)|ensembl:ENST00000267811(transcript)|ensembl:ENST00000557843(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006955"(immune response)|go:"GO:0007399"(nervous system development)|go:"GO:0007517"(muscle organ development)|go:"GO:0008134"(transcription factor binding)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016607"(nuclear speck)|go:"GO:0030154"(cell differentiation)|go:"GO:0035497"(cAMP response element binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043425"(bHLH transcription factor binding)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046332"(SMAD binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0070888"(E-box binding)|go:"GO:0071837"(HMG box domain binding)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR036638|refseq:NP_001309080.1|refseq:NP_001293149.1|refseq:NP_001309088.1|refseq:NP_001309091.1|refseq:NP_001309094.1|dip:DIP-29403N|mint:Q99081|rcsb pdb:2KNH|rcsb pdb:4JOL|reactome:R-HSA-525793|reactome:R-HSA-8939236|reactome:R-HSA-9031628	refseq:NP_001129611.1|refseq:NP_003191.1|refseq:XP_016882669.1|refseq:XP_016882670.1|refseq:XP_016882671.1|dip:DIP-74N|go:"GO:0000785"(chromatin)|go:"GO:0000791"(euchromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|ensembl:ENSG00000071564(gene)|ensembl:ENST00000262965(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0002326"(B cell lineage commitment)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007399"(nervous system development)|go:"GO:0008134"(transcription factor binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0031435"(mitogen-activated protein kinase kinase kinase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033152"("immunoglobulin V(D)J recombination")|go:"GO:0042803"(protein homodimerization activity)|rcsb pdb:2YPA|rcsb pdb:2YPB|rcsb pdb:3U5V|rcsb pdb:6MGN|reactome:R-HSA-525793|reactome:R-HSA-8939236|rcsb pdb:2MH0|go:"GO:0043425"(bHLH transcription factor binding)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045787"(positive regulation of cell cycle)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070644"(vitamin D response element binding)|go:"GO:0070888"(E-box binding)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000045"(regulation of G1/S transition of mitotic cell cycle)|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR036638|rcsb pdb:1HLH	-	-	-	figure legend:Fig 2C|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-embryonic_stem_ cells)|taxid:9606("Human-embryonic_stem_ cells (es cells)")	-	2014/05/30	2014/10/16	rogid:XnBrmDaoz2JZQ66PCjfJsmaQ6209606	rogid:EybpTkEZM4cIWyf25UVHfaOaP3Y9606	intact-crc:A627520DD982A396|rigid:buCgo1DrjYybndSCnwpZsY/23aY	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q99081	uniprotkb:P84022	intact:EBI-722877|uniprotkb:Q86VM2|ensembl:ENSP00000267811|ensembl:ENSP00000453737|uniprotkb:Q7Z3D9|uniprotkb:Q86TC1|uniprotkb:B4E1W1	intact:EBI-347161|intact:EBI-1760241|uniprotkb:O09064|uniprotkb:O09144|uniprotkb:O14510|uniprotkb:O35273|uniprotkb:Q92940|uniprotkb:Q93002|uniprotkb:Q9GKR4|intact:EBI-1965323|uniprotkb:A8K4B6|uniprotkb:B7Z9Q2|uniprotkb:B7Z4Z5|uniprotkb:B7Z6M9|uniprotkb:F5H383|ensembl:ENSP00000332973	psi-mi:htf4_human(display_long)|uniprotkb:Transcription factor HTF-4(gene name synonym)|uniprotkb:E-box-binding protein(gene name synonym)|uniprotkb:DNA-binding protein HTF4(gene name synonym)|uniprotkb:TCF12(gene name)|psi-mi:TCF12(display_short)|uniprotkb:HEB(gene name synonym)|uniprotkb:HTF4(gene name synonym)|uniprotkb:BHLHB20(gene name synonym)|uniprotkb:Class B basic helix-loop-helix protein 20(gene name synonym)	psi-mi:smad3_human(display_long)|uniprotkb:SMAD3(gene name)|psi-mi:SMAD3(display_short)|uniprotkb:MADH3(gene name synonym)|uniprotkb:SMAD family member 3(gene name synonym)|uniprotkb:JV15-2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Yoon et al. (2011)	pubmed:21828274|imex:IM-22642	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-9542666|imex:IM-22642-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001309086.1|refseq:NP_003196.1|refseq:NP_996919.1|refseq:NP_996920.1|refseq:NP_996921.1|refseq:NP_996923.1|ensembl:ENSG00000140262(gene)|ensembl:ENST00000267811(transcript)|ensembl:ENST00000557843(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006955"(immune response)|go:"GO:0007399"(nervous system development)|go:"GO:0007517"(muscle organ development)|go:"GO:0008134"(transcription factor binding)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016607"(nuclear speck)|go:"GO:0030154"(cell differentiation)|go:"GO:0035497"(cAMP response element binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043425"(bHLH transcription factor binding)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046332"(SMAD binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0070888"(E-box binding)|go:"GO:0071837"(HMG box domain binding)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR036638|refseq:NP_001309080.1|refseq:NP_001293149.1|refseq:NP_001309088.1|refseq:NP_001309091.1|refseq:NP_001309094.1|dip:DIP-29403N|mint:Q99081|rcsb pdb:2KNH|rcsb pdb:4JOL|reactome:R-HSA-525793|reactome:R-HSA-8939236|reactome:R-HSA-9031628	refseq:NP_001138574.1|refseq:NP_001138575.1|refseq:NP_005893.1|refseq:NP_001138576.1|dip:DIP-29720N|ensembl:ENSG00000166949(gene)|ensembl:ENST00000327367(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001217"(DNA-binding transcription repressor activity)|go:"GO:0001223"(transcription coactivator binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001657"(ureteric bud development)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001707"(mesoderm formation)|go:"GO:0001756"(somitogenesis)|go:"GO:0001889"(liver development)|go:"GO:0001947"(heart looping)|go:"GO:0002076"(osteoblast development)|go:"GO:0002520"(immune system development)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005160"(transforming growth factor beta receptor binding)|go:"GO:0005518"(collagen binding)|go:"GO:0005634"(nucleus)|go:"GO:0005637"(nuclear inner membrane)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006955"(immune response)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007183"(SMAD protein complex assembly)|go:"GO:0007492"(endoderm development)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010694"(positive regulation of alkaline phosphatase activity)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0016202"(regulation of striated muscle tissue development)|go:"GO:0017015"(regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0017151"(DEAD/H-box RNA helicase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019902"(phosphatase binding)|go:"GO:0023019"(signal transduction involved in regulation of gene expression)|go:"GO:0030154"(cell differentiation)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030325"(adrenal gland development)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0030878"(thyroid gland development)|go:"GO:0031053"(primary miRNA processing)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031962"(mineralocorticoid receptor binding)|go:"GO:0032332"(positive regulation of chondrocyte differentiation)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032909"(regulation of transforming growth factor beta2 production)|go:"GO:0032916"(positive regulation of transforming growth factor beta3 production)|go:"GO:0032924"(activin receptor signaling pathway)|go:"GO:0033689"(negative regulation of osteoblast proliferation)|go:"GO:0035259"(glucocorticoid receptor binding)|go:"GO:0038092"(nodal signaling pathway)|go:"GO:0042060"(wound healing)|go:"GO:0042110"(T cell activation)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043235"(receptor complex)|go:"GO:0043425"(bHLH transcription factor binding)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045216"(cell-cell junction organization)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045930"(negative regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048340"(paraxial mesoderm morphogenesis)|go:"GO:0048589"(developmental growth)|go:"GO:0048617"(embryonic foregut morphogenesis)|go:"GO:0048701"(embryonic cranial skeleton morphogenesis)|go:"GO:0050678"(regulation of epithelial cell proliferation)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0050776"(regulation of immune response)|go:"GO:0050821"(protein stabilization)|go:"GO:0050927"(positive regulation of positive chemotaxis)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051098"(regulation of binding)|go:"GO:0051481"(negative regulation of cytosolic calcium ion concentration)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0060039"(pericardium development)|go:"GO:0060290"(transdifferentiation)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0061045"(negative regulation of wound healing)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0061767"(negative regulation of lung blood pressure)|go:"GO:0070306"(lens fiber cell differentiation)|go:"GO:0070410"(co-SMAD binding)|go:"GO:0070411"(I-SMAD binding)|go:"GO:0070412"(R-SMAD binding)|go:"GO:0071141"(SMAD protein complex)|go:"GO:0071144"(heteromeric SMAD protein complex)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097296"(activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|go:"GO:1901203"(positive regulation of extracellular matrix assembly)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1903243"(negative regulation of cardiac muscle hypertrophy in response to stress)|interpro:IPR001132(SMAD domain, Dwarfin-type)|interpro:IPR003619(MAD homology 1, Dwarfin-type)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR013019(MAD homology, MH1)|interpro:IPR013790(Dwarfin)|interpro:IPR017855(SMAD domain-like)|interpro:IPR036578|mint:P84022|rcsb pdb:1MHD|rcsb pdb:1MJS|rcsb pdb:1MK2|rcsb pdb:1OZJ|rcsb pdb:1U7F|rcsb pdb:2LAJ|rcsb pdb:2LB2|rcsb pdb:5OD6|rcsb pdb:5ODG|rcsb pdb:5XOC|rcsb pdb:6ZMN|reactome:R-HSA-1181150|reactome:R-HSA-1502540|reactome:R-HSA-2173788|reactome:R-HSA-2173789|reactome:R-HSA-2173795|reactome:R-HSA-2173796|reactome:R-HSA-3304356|reactome:R-HSA-3311021|reactome:R-HSA-3315487|reactome:R-HSA-3656532|reactome:R-HSA-5689880|reactome:R-HSA-8941855|reactome:R-HSA-8952158|reactome:R-HSA-9008059|reactome:R-HSA-9013695|reactome:R-HSA-9615017|reactome:R-HSA-9617828	-	-	-	figure legend:Fig 2C|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-embryonic_stem_ cells)|taxid:9606("Human-embryonic_stem_ cells (es cells)")	-	2014/05/30	2014/10/16	rogid:XnBrmDaoz2JZQ66PCjfJsmaQ6209606	rogid:47/62Iz3MOJAyDNCYtisL+unRDg9606	intact-crc:E2C27A3BFFF85C1F|rigid:thvt0TjyBcwqnaw1ZjbtMRaihro	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:O75593	uniprotkb:P84022	intact:EBI-1759806|uniprotkb:D3DWM4|ensembl:ENSP00000366534	intact:EBI-347161|intact:EBI-1760241|uniprotkb:O09064|uniprotkb:O09144|uniprotkb:O14510|uniprotkb:O35273|uniprotkb:Q92940|uniprotkb:Q93002|uniprotkb:Q9GKR4|intact:EBI-1965323|uniprotkb:A8K4B6|uniprotkb:B7Z9Q2|uniprotkb:B7Z4Z5|uniprotkb:B7Z6M9|uniprotkb:F5H383|ensembl:ENSP00000332973	psi-mi:foxh1_human(display_long)|uniprotkb:FOXH1(gene name)|psi-mi:FOXH1(display_short)|uniprotkb:FAST1(gene name synonym)|uniprotkb:FAST2(gene name synonym)|uniprotkb:Forkhead activin signal transducer 1(gene name synonym)|uniprotkb:Forkhead activin signal transducer 2(gene name synonym)	psi-mi:smad3_human(display_long)|uniprotkb:SMAD3(gene name)|psi-mi:SMAD3(display_short)|uniprotkb:MADH3(gene name synonym)|uniprotkb:SMAD family member 3(gene name synonym)|uniprotkb:JV15-2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Yoon et al. (2011)	pubmed:21828274|imex:IM-22642	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-9542651|imex:IM-22642-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_003914.1|ensembl:ENSG00000160973(gene)|ensembl:ENST00000377317(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001947"(heart looping)|go:"GO:0003139"(secondary heart field specification)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0003215"(cardiac right ventricle morphogenesis)|go:"GO:0003222"(ventricular trabecula myocardium morphogenesis)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0032444"(activin responsive factor complex)|go:"GO:0033147"(negative regulation of intracellular estrogen receptor signaling pathway)|go:"GO:0035054"(embryonic heart tube anterior/posterior pattern specification)|go:"GO:0035909"(aorta morphogenesis)|go:"GO:0043425"(bHLH transcription factor binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046332"(SMAD binding)|go:"GO:0048318"(axial mesoderm development)|go:"GO:0050681"(androgen receptor binding)|go:"GO:0060766"(negative regulation of androgen receptor signaling pathway)|go:"GO:0070410"(co-SMAD binding)|go:"GO:0070412"(R-SMAD binding)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:1900164"(nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry)|interpro:IPR001766(Fork head transcription factor)|interpro:IPR030456|interpro:IPR036388|interpro:IPR036390|rcsb pdb:5XOC|reactome:R-HSA-1181150|reactome:R-HSA-1502540	refseq:NP_001138574.1|refseq:NP_001138575.1|refseq:NP_005893.1|refseq:NP_001138576.1|dip:DIP-29720N|ensembl:ENSG00000166949(gene)|ensembl:ENST00000327367(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001217"(DNA-binding transcription repressor activity)|go:"GO:0001223"(transcription coactivator binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001657"(ureteric bud development)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001707"(mesoderm formation)|go:"GO:0001756"(somitogenesis)|go:"GO:0001889"(liver development)|go:"GO:0001947"(heart looping)|go:"GO:0002076"(osteoblast development)|go:"GO:0002520"(immune system development)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005160"(transforming growth factor beta receptor binding)|go:"GO:0005518"(collagen binding)|go:"GO:0005634"(nucleus)|go:"GO:0005637"(nuclear inner membrane)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006955"(immune response)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007183"(SMAD protein complex assembly)|go:"GO:0007492"(endoderm development)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010694"(positive regulation of alkaline phosphatase activity)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0016202"(regulation of striated muscle tissue development)|go:"GO:0017015"(regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0017151"(DEAD/H-box RNA helicase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019902"(phosphatase binding)|go:"GO:0023019"(signal transduction involved in regulation of gene expression)|go:"GO:0030154"(cell differentiation)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030325"(adrenal gland development)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0030878"(thyroid gland development)|go:"GO:0031053"(primary miRNA processing)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031962"(mineralocorticoid receptor binding)|go:"GO:0032332"(positive regulation of chondrocyte differentiation)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032909"(regulation of transforming growth factor beta2 production)|go:"GO:0032916"(positive regulation of transforming growth factor beta3 production)|go:"GO:0032924"(activin receptor signaling pathway)|go:"GO:0033689"(negative regulation of osteoblast proliferation)|go:"GO:0035259"(glucocorticoid receptor binding)|go:"GO:0038092"(nodal signaling pathway)|go:"GO:0042060"(wound healing)|go:"GO:0042110"(T cell activation)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043235"(receptor complex)|go:"GO:0043425"(bHLH transcription factor binding)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045216"(cell-cell junction organization)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045930"(negative regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048340"(paraxial mesoderm morphogenesis)|go:"GO:0048589"(developmental growth)|go:"GO:0048617"(embryonic foregut morphogenesis)|go:"GO:0048701"(embryonic cranial skeleton morphogenesis)|go:"GO:0050678"(regulation of epithelial cell proliferation)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0050776"(regulation of immune response)|go:"GO:0050821"(protein stabilization)|go:"GO:0050927"(positive regulation of positive chemotaxis)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051098"(regulation of binding)|go:"GO:0051481"(negative regulation of cytosolic calcium ion concentration)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0060039"(pericardium development)|go:"GO:0060290"(transdifferentiation)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0061045"(negative regulation of wound healing)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0061767"(negative regulation of lung blood pressure)|go:"GO:0070306"(lens fiber cell differentiation)|go:"GO:0070410"(co-SMAD binding)|go:"GO:0070411"(I-SMAD binding)|go:"GO:0070412"(R-SMAD binding)|go:"GO:0071141"(SMAD protein complex)|go:"GO:0071144"(heteromeric SMAD protein complex)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097296"(activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|go:"GO:1901203"(positive regulation of extracellular matrix assembly)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1903243"(negative regulation of cardiac muscle hypertrophy in response to stress)|interpro:IPR001132(SMAD domain, Dwarfin-type)|interpro:IPR003619(MAD homology 1, Dwarfin-type)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR013019(MAD homology, MH1)|interpro:IPR013790(Dwarfin)|interpro:IPR017855(SMAD domain-like)|interpro:IPR036578|mint:P84022|rcsb pdb:1MHD|rcsb pdb:1MJS|rcsb pdb:1MK2|rcsb pdb:1OZJ|rcsb pdb:1U7F|rcsb pdb:2LAJ|rcsb pdb:2LB2|rcsb pdb:5OD6|rcsb pdb:5ODG|rcsb pdb:5XOC|rcsb pdb:6ZMN|reactome:R-HSA-1181150|reactome:R-HSA-1502540|reactome:R-HSA-2173788|reactome:R-HSA-2173789|reactome:R-HSA-2173795|reactome:R-HSA-2173796|reactome:R-HSA-3304356|reactome:R-HSA-3311021|reactome:R-HSA-3315487|reactome:R-HSA-3656532|reactome:R-HSA-5689880|reactome:R-HSA-8941855|reactome:R-HSA-8952158|reactome:R-HSA-9008059|reactome:R-HSA-9013695|reactome:R-HSA-9615017|reactome:R-HSA-9617828	-	-	-	figure legend:Fig 2C|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-embryonic_stem_ cells)|taxid:9606("Human-embryonic_stem_ cells (es cells)")	-	2014/05/30	2014/10/16	rogid:uZzViiPJyxYi9PHrgIEN/ZBW5tI9606	rogid:47/62Iz3MOJAyDNCYtisL+unRDg9606	intact-crc:FDA097191CD841BD|rigid:Y5RMotShIj+XztQavHS57+Mxf00	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P15923	uniprotkb:O75593	intact:EBI-769630|uniprotkb:Q2TB40|uniprotkb:P15883|uniprotkb:Q14208|uniprotkb:Q14635|uniprotkb:Q14636|uniprotkb:Q9UPI9|uniprotkb:Q2TB39|intact:EBI-11119608|ensembl:ENSP00000262965	intact:EBI-1759806|uniprotkb:D3DWM4|ensembl:ENSP00000366534	psi-mi:tfe2_human(display_long)|uniprotkb:Immunoglobulin enhancer-binding factor E12/E47(gene name synonym)|uniprotkb:Transcription factor 3(gene name synonym)|uniprotkb:Immunoglobulin transcription factor 1(gene name synonym)|uniprotkb:Transcription factor ITF-1(gene name synonym)|uniprotkb:Kappa-E2-binding factor(gene name synonym)|uniprotkb:TCF3(gene name)|psi-mi:TCF3(display_short)|uniprotkb:E2A(gene name synonym)|uniprotkb:ITF1(gene name synonym)|uniprotkb:BHLHB21(gene name synonym)|uniprotkb:Class B basic helix-loop-helix protein 21(gene name synonym)	psi-mi:foxh1_human(display_long)|uniprotkb:FOXH1(gene name)|psi-mi:FOXH1(display_short)|uniprotkb:FAST1(gene name synonym)|uniprotkb:FAST2(gene name synonym)|uniprotkb:Forkhead activin signal transducer 1(gene name synonym)|uniprotkb:Forkhead activin signal transducer 2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Yoon et al. (2011)	pubmed:21828274|imex:IM-22642	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-9542655|imex:IM-22642-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001129611.1|refseq:NP_003191.1|refseq:XP_016882669.1|refseq:XP_016882670.1|refseq:XP_016882671.1|dip:DIP-74N|go:"GO:0000785"(chromatin)|go:"GO:0000791"(euchromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|ensembl:ENSG00000071564(gene)|ensembl:ENST00000262965(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0002326"(B cell lineage commitment)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007399"(nervous system development)|go:"GO:0008134"(transcription factor binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0031435"(mitogen-activated protein kinase kinase kinase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033152"("immunoglobulin V(D)J recombination")|go:"GO:0042803"(protein homodimerization activity)|rcsb pdb:2YPA|rcsb pdb:2YPB|rcsb pdb:3U5V|rcsb pdb:6MGN|reactome:R-HSA-525793|reactome:R-HSA-8939236|rcsb pdb:2MH0|go:"GO:0043425"(bHLH transcription factor binding)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045787"(positive regulation of cell cycle)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070644"(vitamin D response element binding)|go:"GO:0070888"(E-box binding)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000045"(regulation of G1/S transition of mitotic cell cycle)|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR036638|rcsb pdb:1HLH	refseq:NP_003914.1|ensembl:ENSG00000160973(gene)|ensembl:ENST00000377317(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001947"(heart looping)|go:"GO:0003139"(secondary heart field specification)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0003215"(cardiac right ventricle morphogenesis)|go:"GO:0003222"(ventricular trabecula myocardium morphogenesis)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0032444"(activin responsive factor complex)|go:"GO:0033147"(negative regulation of intracellular estrogen receptor signaling pathway)|go:"GO:0035054"(embryonic heart tube anterior/posterior pattern specification)|go:"GO:0035909"(aorta morphogenesis)|go:"GO:0043425"(bHLH transcription factor binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046332"(SMAD binding)|go:"GO:0048318"(axial mesoderm development)|go:"GO:0050681"(androgen receptor binding)|go:"GO:0060766"(negative regulation of androgen receptor signaling pathway)|go:"GO:0070410"(co-SMAD binding)|go:"GO:0070412"(R-SMAD binding)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:1900164"(nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry)|interpro:IPR001766(Fork head transcription factor)|interpro:IPR030456|interpro:IPR036388|interpro:IPR036390|rcsb pdb:5XOC|reactome:R-HSA-1181150|reactome:R-HSA-1502540	-	-	-	figure legend:Fig 2C|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-embryonic_stem_ cells)|taxid:9606("Human-embryonic_stem_ cells (es cells)")	-	2014/05/30	2014/10/16	rogid:EybpTkEZM4cIWyf25UVHfaOaP3Y9606	rogid:uZzViiPJyxYi9PHrgIEN/ZBW5tI9606	intact-crc:EF0827D9DC58F6A2|rigid:PCtNekxs10Z1HBNRdYrEvgCKmtQ	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)