#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:P40336 uniprotkb:Q9QZ88 intact:EBI-775981|uniprotkb:Q3TGY3|uniprotkb:Q3THM5|uniprotkb:Q3TW99|uniprotkb:Q3UD54|uniprotkb:Q8C1E9|ensembl:ENSMUSP00000101087 intact:EBI-8334188|intact:MINT-4140090|uniprotkb:Q9D107|uniprotkb:Q3UCZ0|ensembl:ENSMUSP00000121020 psi-mi:vp26a_mouse(display_long)|uniprotkb:Vesicle protein sorting 26A(gene name synonym)|uniprotkb:H58 protein(gene name synonym)|uniprotkb:Vps26a(gene name)|psi-mi:Vps26a(display_short)|uniprotkb:Vps26(gene name synonym) psi-mi:vps29_mouse(display_long)|uniprotkb:Vps29(gene name)|psi-mi:Vps29(display_short)|uniprotkb:Vesicle protein sorting 29(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Kim et al. (2010) pubmed:21040701|imex:IM-23234 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-9847421|imex:IM-23234-7 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001106826.1|refseq:NP_598433.1|dip:DIP-32041N|ensembl:ENSMUSG00000020078(gene)|ensembl:ENSMUST00000105447(transcript)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0010008"(endosome membrane)|go:"GO:0030904"(retromer complex)|go:"GO:0030906"(retromer, cargo-selective complex)|go:"GO:0031982"(vesicle)|go:"GO:0032456"(endocytic recycling)|go:"GO:0042147"(retrograde transport, endosome to Golgi)|go:"GO:0097422"(tubular endosome)|interpro:IPR014752(Arrestin, C-terminal)|interpro:IPR028934|mint:P40336|rcsb pdb:4P2A|rcsb pdb:6VAC|reactome:R-MMU-3238698 refseq:NP_062754.1|refseq:NP_001334382.1|dip:DIP-60495N|ensembl:ENSMUSG00000029462(gene)|ensembl:ENSMUST00000155671(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006896"(Golgi to vacuole transport)|go:"GO:0010008"(endosome membrane)|go:"GO:0030904"(retromer complex)|go:"GO:0030906"(retromer, cargo-selective complex)|go:"GO:0032456"(endocytic recycling)|go:"GO:0042147"(retrograde transport, endosome to Golgi)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0046872"(metal ion binding)|interpro:IPR000979(Protein of unknown function UPF0025)|interpro:IPR024654|interpro:IPR028661|interpro:IPR029052|mint:Q9QZ88|rcsb pdb:1Z2W|rcsb pdb:1Z2X|rcsb pdb:3PSN|rcsb pdb:3PSO|rcsb pdb:6TL0|rcsb pdb:6VAB|rcsb pdb:6VAC|reactome:R-MMU-3238698|go:"GO:0005768"(endosome) - - function:"Essential component of the retromer complex, a complex required to retrieve lysosomal enzyme receptors (IGF2R and M6PR) from endosomes to the trans-Golgi network. Also required to regulate transcytosis of the polymeric immunoglobulin receptor (pIgR-pIgA). Has low protein phosphatase activity towards a serine-phosphorylated peptide derived from IGF2R (in vitro) (By similarity). Has no activity towards p-nitrophenylphosphate, p-nitrophenylphosphorylcholine or phosphatidylinositlphosphates (in vitro)"|comment:mint figure legend:2|comment:CoIP in VPS26b-/- mice|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain) - 2014/10/02 2014/10/16 rogid:fzT+kSNk6/aqTm7hSsSbItmgyYE10090 rogid:XLAmkQXgIRvAF4JDcavWOR9CnsY10090 intact-crc:EC0399EFE042470A|rigid:VQRb+Yegl2A9m6WeZRxUJlm7nuo false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:P40336 uniprotkb:Q9EQH3 intact:EBI-775981|uniprotkb:Q3TGY3|uniprotkb:Q3THM5|uniprotkb:Q3TW99|uniprotkb:Q3UD54|uniprotkb:Q8C1E9|ensembl:ENSMUSP00000101087 intact:EBI-775825|uniprotkb:Q61123|ensembl:ENSMUSP00000034131 psi-mi:vp26a_mouse(display_long)|uniprotkb:Vesicle protein sorting 26A(gene name synonym)|uniprotkb:H58 protein(gene name synonym)|uniprotkb:Vps26a(gene name)|psi-mi:Vps26a(display_short)|uniprotkb:Vps26(gene name synonym) psi-mi:vps35_mouse(display_long)|uniprotkb:Vesicle protein sorting 35(gene name synonym)|uniprotkb:Maternal-embryonic 3(gene name synonym)|uniprotkb:Vps35(gene name)|psi-mi:Vps35(display_short)|uniprotkb:Mem3(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Kim et al. (2010) pubmed:21040701|imex:IM-23234 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-9847421|imex:IM-23234-7 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001106826.1|refseq:NP_598433.1|dip:DIP-32041N|ensembl:ENSMUSG00000020078(gene)|ensembl:ENSMUST00000105447(transcript)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0010008"(endosome membrane)|go:"GO:0030904"(retromer complex)|go:"GO:0030906"(retromer, cargo-selective complex)|go:"GO:0031982"(vesicle)|go:"GO:0032456"(endocytic recycling)|go:"GO:0042147"(retrograde transport, endosome to Golgi)|go:"GO:0097422"(tubular endosome)|interpro:IPR014752(Arrestin, C-terminal)|interpro:IPR028934|mint:P40336|rcsb pdb:4P2A|rcsb pdb:6VAC|reactome:R-MMU-3238698 refseq:NP_075373.1|dip:DIP-32210N|ensembl:ENSMUSG00000031696(gene)|ensembl:ENSMUST00000034131(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005829"(cytosol)|go:"GO:0006624"(vacuolar protein processing)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0007040"(lysosome organization)|go:"GO:0007416"(synapse assembly)|go:"GO:0010008"(endosome membrane)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010821"(regulation of mitochondrion organization)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030904"(retromer complex)|go:"GO:0030906"(retromer, cargo-selective complex)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031648"(protein destabilization)|go:"GO:0031748"(D1 dopamine receptor binding)|go:"GO:0032268"(regulation of cellular protein metabolic process)|go:"GO:0032456"(endocytic recycling)|go:"GO:0032463"(negative regulation of protein homooligomerization)|go:"GO:0033365"(protein localization to organelle)|go:"GO:0036010"(protein localization to endosome)|go:"GO:0042147"(retrograde transport, endosome to Golgi)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043653"(mitochondrial fragmentation involved in apoptotic process)|go:"GO:0045056"(transcytosis)|go:"GO:0045202"(synapse)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0050882"(voluntary musculoskeletal movement)|go:"GO:0060161"(positive regulation of dopamine receptor signaling pathway)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0061357"(positive regulation of Wnt protein secretion)|go:"GO:0090141"(positive regulation of mitochondrial fission)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0090326"(positive regulation of locomotion involved in locomotory behavior)|go:"GO:0097422"(tubular endosome)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098887"(neurotransmitter receptor transport, endosome to postsynaptic membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099003"(vesicle-mediated transport in synapse)|go:"GO:0099073"(mitochondrion-derived vesicle)|go:"GO:0099074"(mitochondrion to lysosome transport)|go:"GO:0099639"(neurotransmitter receptor transport, endosome to plasma membrane)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902823"(negative regulation of late endosome to lysosome transport)|go:"GO:1902950"(regulation of dendritic spine maintenance)|go:"GO:1903181"(positive regulation of dopamine biosynthetic process)|go:"GO:1903364"(positive regulation of cellular protein catabolic process)|go:"GO:1903828"(negative regulation of protein localization)|go:"GO:1905166"(negative regulation of lysosomal protein catabolic process)|go:"GO:2000331"(regulation of terminal button organization)|interpro:IPR005378(Vacuolar protein sorting-associated protein 35)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR042491|mint:Q9EQH3|rcsb pdb:6VAB|rcsb pdb:6VAC|reactome:R-MMU-3238698 - - - figure legend:2|comment:CoIP in VPS26b-/- mice|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain) - 2014/10/02 2014/10/16 rogid:fzT+kSNk6/aqTm7hSsSbItmgyYE10090 rogid:dK5TqSajxrGKjiNwRjeZCV519XE10090 intact-crc:EC0399EFE042470A|rigid:VQRb+Yegl2A9m6WeZRxUJlm7nuo false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q8C0E2 uniprotkb:Q9QZ88 intact:EBI-8314940|ensembl:ENSMUSP00000034470|uniprotkb:Q8K2V3|uniprotkb:Q3TN45|intact:MINT-3253852 intact:EBI-8334188|intact:MINT-4140090|uniprotkb:Q9D107|uniprotkb:Q3UCZ0|ensembl:ENSMUSP00000121020 psi-mi:vp26b_mouse(display_long)|uniprotkb:Vps26b(gene name)|psi-mi:Vps26b(display_short)|uniprotkb:Vesicle protein sorting 26B(gene name synonym) psi-mi:vps29_mouse(display_long)|uniprotkb:Vps29(gene name)|psi-mi:Vps29(display_short)|uniprotkb:Vesicle protein sorting 29(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Kim et al. (2010) pubmed:21040701|imex:IM-23234 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-9847442|imex:IM-23234-10 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000031988(gene)|ensembl:ENSMUST00000034470(transcript)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005829"(cytosol)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0030904"(retromer complex)|go:"GO:0042147"(retrograde transport, endosome to Golgi)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0071346"(cellular response to interferon-gamma)|interpro:IPR014752(Arrestin, C-terminal)|interpro:IPR028934|mint:Q8C0E2|rcsb pdb:2R51|rcsb pdb:3LH8|rcsb pdb:3LH9|rcsb pdb:3LHA|refseq:NP_821170.1 refseq:NP_062754.1|refseq:NP_001334382.1|dip:DIP-60495N|ensembl:ENSMUSG00000029462(gene)|ensembl:ENSMUST00000155671(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006896"(Golgi to vacuole transport)|go:"GO:0010008"(endosome membrane)|go:"GO:0030904"(retromer complex)|go:"GO:0030906"(retromer, cargo-selective complex)|go:"GO:0032456"(endocytic recycling)|go:"GO:0042147"(retrograde transport, endosome to Golgi)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0046872"(metal ion binding)|interpro:IPR000979(Protein of unknown function UPF0025)|interpro:IPR024654|interpro:IPR028661|interpro:IPR029052|mint:Q9QZ88|rcsb pdb:1Z2W|rcsb pdb:1Z2X|rcsb pdb:3PSN|rcsb pdb:3PSO|rcsb pdb:6TL0|rcsb pdb:6VAB|rcsb pdb:6VAC|reactome:R-MMU-3238698|go:"GO:0005768"(endosome) - comment:mint|function:"Probable component of the retromer complex, a complex required to retrieve lysosomal enzyme receptors (IGF2R and M6PR) from endosomes to the trans-Golgi network" function:"Essential component of the retromer complex, a complex required to retrieve lysosomal enzyme receptors (IGF2R and M6PR) from endosomes to the trans-Golgi network. Also required to regulate transcytosis of the polymeric immunoglobulin receptor (pIgR-pIgA). Has low protein phosphatase activity towards a serine-phosphorylated peptide derived from IGF2R (in vitro) (By similarity). Has no activity towards p-nitrophenylphosphate, p-nitrophenylphosphorylcholine or phosphatidylinositlphosphates (in vitro)"|comment:mint figure legend:3B|comment:CoIP in VPS26b-/- mice wit transfected FLAG-Vps26b|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain) - 2014/10/02 2014/10/16 rogid:0ldtjq7g6fEiaFTAusA8J+Xy4Qg10090 rogid:XLAmkQXgIRvAF4JDcavWOR9CnsY10090 intact-crc:B86DD24A89736831|rigid:BdSqHzHqKodB/ABIIJ4qGezudlQ false flag tag:?-? - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q8C0E2 uniprotkb:Q9EQH3 intact:EBI-8314940|ensembl:ENSMUSP00000034470|uniprotkb:Q8K2V3|uniprotkb:Q3TN45|intact:MINT-3253852 intact:EBI-775825|uniprotkb:Q61123|ensembl:ENSMUSP00000034131 psi-mi:vp26b_mouse(display_long)|uniprotkb:Vps26b(gene name)|psi-mi:Vps26b(display_short)|uniprotkb:Vesicle protein sorting 26B(gene name synonym) psi-mi:vps35_mouse(display_long)|uniprotkb:Vesicle protein sorting 35(gene name synonym)|uniprotkb:Maternal-embryonic 3(gene name synonym)|uniprotkb:Vps35(gene name)|psi-mi:Vps35(display_short)|uniprotkb:Mem3(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Kim et al. (2010) pubmed:21040701|imex:IM-23234 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-9847442|imex:IM-23234-10 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000031988(gene)|ensembl:ENSMUST00000034470(transcript)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005829"(cytosol)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0030904"(retromer complex)|go:"GO:0042147"(retrograde transport, endosome to Golgi)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0071346"(cellular response to interferon-gamma)|interpro:IPR014752(Arrestin, C-terminal)|interpro:IPR028934|mint:Q8C0E2|rcsb pdb:2R51|rcsb pdb:3LH8|rcsb pdb:3LH9|rcsb pdb:3LHA|refseq:NP_821170.1 refseq:NP_075373.1|dip:DIP-32210N|ensembl:ENSMUSG00000031696(gene)|ensembl:ENSMUST00000034131(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005829"(cytosol)|go:"GO:0006624"(vacuolar protein processing)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0007040"(lysosome organization)|go:"GO:0007416"(synapse assembly)|go:"GO:0010008"(endosome membrane)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010821"(regulation of mitochondrion organization)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030904"(retromer complex)|go:"GO:0030906"(retromer, cargo-selective complex)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031648"(protein destabilization)|go:"GO:0031748"(D1 dopamine receptor binding)|go:"GO:0032268"(regulation of cellular protein metabolic process)|go:"GO:0032456"(endocytic recycling)|go:"GO:0032463"(negative regulation of protein homooligomerization)|go:"GO:0033365"(protein localization to organelle)|go:"GO:0036010"(protein localization to endosome)|go:"GO:0042147"(retrograde transport, endosome to Golgi)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043653"(mitochondrial fragmentation involved in apoptotic process)|go:"GO:0045056"(transcytosis)|go:"GO:0045202"(synapse)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0050882"(voluntary musculoskeletal movement)|go:"GO:0060161"(positive regulation of dopamine receptor signaling pathway)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0061357"(positive regulation of Wnt protein secretion)|go:"GO:0090141"(positive regulation of mitochondrial fission)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0090326"(positive regulation of locomotion involved in locomotory behavior)|go:"GO:0097422"(tubular endosome)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098887"(neurotransmitter receptor transport, endosome to postsynaptic membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099003"(vesicle-mediated transport in synapse)|go:"GO:0099073"(mitochondrion-derived vesicle)|go:"GO:0099074"(mitochondrion to lysosome transport)|go:"GO:0099639"(neurotransmitter receptor transport, endosome to plasma membrane)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902823"(negative regulation of late endosome to lysosome transport)|go:"GO:1902950"(regulation of dendritic spine maintenance)|go:"GO:1903181"(positive regulation of dopamine biosynthetic process)|go:"GO:1903364"(positive regulation of cellular protein catabolic process)|go:"GO:1903828"(negative regulation of protein localization)|go:"GO:1905166"(negative regulation of lysosomal protein catabolic process)|go:"GO:2000331"(regulation of terminal button organization)|interpro:IPR005378(Vacuolar protein sorting-associated protein 35)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR042491|mint:Q9EQH3|rcsb pdb:6VAB|rcsb pdb:6VAC|reactome:R-MMU-3238698 - comment:mint|function:"Probable component of the retromer complex, a complex required to retrieve lysosomal enzyme receptors (IGF2R and M6PR) from endosomes to the trans-Golgi network" - figure legend:3B|comment:CoIP in VPS26b-/- mice wit transfected FLAG-Vps26b|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain) - 2014/10/02 2014/10/16 rogid:0ldtjq7g6fEiaFTAusA8J+Xy4Qg10090 rogid:dK5TqSajxrGKjiNwRjeZCV519XE10090 intact-crc:B86DD24A89736831|rigid:BdSqHzHqKodB/ABIIJ4qGezudlQ false flag tag:?-? - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q9QZ88 uniprotkb:Q9EQH3 intact:EBI-8334188|intact:MINT-4140090|uniprotkb:Q9D107|uniprotkb:Q3UCZ0|ensembl:ENSMUSP00000121020 intact:EBI-775825|uniprotkb:Q61123|ensembl:ENSMUSP00000034131 psi-mi:vps29_mouse(display_long)|uniprotkb:Vps29(gene name)|psi-mi:Vps29(display_short)|uniprotkb:Vesicle protein sorting 29(gene name synonym) psi-mi:vps35_mouse(display_long)|uniprotkb:Vesicle protein sorting 35(gene name synonym)|uniprotkb:Maternal-embryonic 3(gene name synonym)|uniprotkb:Vps35(gene name)|psi-mi:Vps35(display_short)|uniprotkb:Mem3(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Kim et al. (2010) pubmed:21040701|imex:IM-23234 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-9847436|imex:IM-23234-9 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_062754.1|refseq:NP_001334382.1|dip:DIP-60495N|ensembl:ENSMUSG00000029462(gene)|ensembl:ENSMUST00000155671(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006896"(Golgi to vacuole transport)|go:"GO:0010008"(endosome membrane)|go:"GO:0030904"(retromer complex)|go:"GO:0030906"(retromer, cargo-selective complex)|go:"GO:0032456"(endocytic recycling)|go:"GO:0042147"(retrograde transport, endosome to Golgi)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0046872"(metal ion binding)|interpro:IPR000979(Protein of unknown function UPF0025)|interpro:IPR024654|interpro:IPR028661|interpro:IPR029052|mint:Q9QZ88|rcsb pdb:1Z2W|rcsb pdb:1Z2X|rcsb pdb:3PSN|rcsb pdb:3PSO|rcsb pdb:6TL0|rcsb pdb:6VAB|rcsb pdb:6VAC|reactome:R-MMU-3238698|go:"GO:0005768"(endosome) refseq:NP_075373.1|dip:DIP-32210N|ensembl:ENSMUSG00000031696(gene)|ensembl:ENSMUST00000034131(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005829"(cytosol)|go:"GO:0006624"(vacuolar protein processing)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0007040"(lysosome organization)|go:"GO:0007416"(synapse assembly)|go:"GO:0010008"(endosome membrane)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010821"(regulation of mitochondrion organization)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030904"(retromer complex)|go:"GO:0030906"(retromer, cargo-selective complex)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031648"(protein destabilization)|go:"GO:0031748"(D1 dopamine receptor binding)|go:"GO:0032268"(regulation of cellular protein metabolic process)|go:"GO:0032456"(endocytic recycling)|go:"GO:0032463"(negative regulation of protein homooligomerization)|go:"GO:0033365"(protein localization to organelle)|go:"GO:0036010"(protein localization to endosome)|go:"GO:0042147"(retrograde transport, endosome to Golgi)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043653"(mitochondrial fragmentation involved in apoptotic process)|go:"GO:0045056"(transcytosis)|go:"GO:0045202"(synapse)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0050882"(voluntary musculoskeletal movement)|go:"GO:0060161"(positive regulation of dopamine receptor signaling pathway)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0061357"(positive regulation of Wnt protein secretion)|go:"GO:0090141"(positive regulation of mitochondrial fission)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0090326"(positive regulation of locomotion involved in locomotory behavior)|go:"GO:0097422"(tubular endosome)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098887"(neurotransmitter receptor transport, endosome to postsynaptic membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099003"(vesicle-mediated transport in synapse)|go:"GO:0099073"(mitochondrion-derived vesicle)|go:"GO:0099074"(mitochondrion to lysosome transport)|go:"GO:0099639"(neurotransmitter receptor transport, endosome to plasma membrane)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902823"(negative regulation of late endosome to lysosome transport)|go:"GO:1902950"(regulation of dendritic spine maintenance)|go:"GO:1903181"(positive regulation of dopamine biosynthetic process)|go:"GO:1903364"(positive regulation of cellular protein catabolic process)|go:"GO:1903828"(negative regulation of protein localization)|go:"GO:1905166"(negative regulation of lysosomal protein catabolic process)|go:"GO:2000331"(regulation of terminal button organization)|interpro:IPR005378(Vacuolar protein sorting-associated protein 35)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR042491|mint:Q9EQH3|rcsb pdb:6VAB|rcsb pdb:6VAC|reactome:R-MMU-3238698 - function:"Essential component of the retromer complex, a complex required to retrieve lysosomal enzyme receptors (IGF2R and M6PR) from endosomes to the trans-Golgi network. Also required to regulate transcytosis of the polymeric immunoglobulin receptor (pIgR-pIgA). Has low protein phosphatase activity towards a serine-phosphorylated peptide derived from IGF2R (in vitro) (By similarity). Has no activity towards p-nitrophenylphosphate, p-nitrophenylphosphorylcholine or phosphatidylinositlphosphates (in vitro)"|comment:mint - figure legend:2|comment:CoIP in VPS26b-/- mice|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain) - 2014/10/02 2014/10/16 rogid:XLAmkQXgIRvAF4JDcavWOR9CnsY10090 rogid:dK5TqSajxrGKjiNwRjeZCV519XE10090 intact-crc:DBEE2E5204D422F8|rigid:VQRb+Yegl2A9m6WeZRxUJlm7nuo false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q9QZ88 uniprotkb:P40336 intact:EBI-8334188|intact:MINT-4140090|uniprotkb:Q9D107|uniprotkb:Q3UCZ0|ensembl:ENSMUSP00000121020 intact:EBI-775981|uniprotkb:Q3TGY3|uniprotkb:Q3THM5|uniprotkb:Q3TW99|uniprotkb:Q3UD54|uniprotkb:Q8C1E9|ensembl:ENSMUSP00000101087 psi-mi:vps29_mouse(display_long)|uniprotkb:Vps29(gene name)|psi-mi:Vps29(display_short)|uniprotkb:Vesicle protein sorting 29(gene name synonym) psi-mi:vp26a_mouse(display_long)|uniprotkb:Vesicle protein sorting 26A(gene name synonym)|uniprotkb:H58 protein(gene name synonym)|uniprotkb:Vps26a(gene name)|psi-mi:Vps26a(display_short)|uniprotkb:Vps26(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Kim et al. (2010) pubmed:21040701|imex:IM-23234 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-9847436|imex:IM-23234-9 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_062754.1|refseq:NP_001334382.1|dip:DIP-60495N|ensembl:ENSMUSG00000029462(gene)|ensembl:ENSMUST00000155671(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006896"(Golgi to vacuole transport)|go:"GO:0010008"(endosome membrane)|go:"GO:0030904"(retromer complex)|go:"GO:0030906"(retromer, cargo-selective complex)|go:"GO:0032456"(endocytic recycling)|go:"GO:0042147"(retrograde transport, endosome to Golgi)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0046872"(metal ion binding)|interpro:IPR000979(Protein of unknown function UPF0025)|interpro:IPR024654|interpro:IPR028661|interpro:IPR029052|mint:Q9QZ88|rcsb pdb:1Z2W|rcsb pdb:1Z2X|rcsb pdb:3PSN|rcsb pdb:3PSO|rcsb pdb:6TL0|rcsb pdb:6VAB|rcsb pdb:6VAC|reactome:R-MMU-3238698|go:"GO:0005768"(endosome) refseq:NP_001106826.1|refseq:NP_598433.1|dip:DIP-32041N|ensembl:ENSMUSG00000020078(gene)|ensembl:ENSMUST00000105447(transcript)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0010008"(endosome membrane)|go:"GO:0030904"(retromer complex)|go:"GO:0030906"(retromer, cargo-selective complex)|go:"GO:0031982"(vesicle)|go:"GO:0032456"(endocytic recycling)|go:"GO:0042147"(retrograde transport, endosome to Golgi)|go:"GO:0097422"(tubular endosome)|interpro:IPR014752(Arrestin, C-terminal)|interpro:IPR028934|mint:P40336|rcsb pdb:4P2A|rcsb pdb:6VAC|reactome:R-MMU-3238698 - function:"Essential component of the retromer complex, a complex required to retrieve lysosomal enzyme receptors (IGF2R and M6PR) from endosomes to the trans-Golgi network. Also required to regulate transcytosis of the polymeric immunoglobulin receptor (pIgR-pIgA). Has low protein phosphatase activity towards a serine-phosphorylated peptide derived from IGF2R (in vitro) (By similarity). Has no activity towards p-nitrophenylphosphate, p-nitrophenylphosphorylcholine or phosphatidylinositlphosphates (in vitro)"|comment:mint - figure legend:2|comment:CoIP in VPS26b-/- mice|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain) - 2014/10/02 2014/10/16 rogid:XLAmkQXgIRvAF4JDcavWOR9CnsY10090 rogid:fzT+kSNk6/aqTm7hSsSbItmgyYE10090 intact-crc:DBEE2E5204D422F8|rigid:VQRb+Yegl2A9m6WeZRxUJlm7nuo false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q9EQH3 uniprotkb:Q9QZ88 intact:EBI-775825|uniprotkb:Q61123|ensembl:ENSMUSP00000034131 intact:EBI-8334188|intact:MINT-4140090|uniprotkb:Q9D107|uniprotkb:Q3UCZ0|ensembl:ENSMUSP00000121020 psi-mi:vps35_mouse(display_long)|uniprotkb:Vesicle protein sorting 35(gene name synonym)|uniprotkb:Maternal-embryonic 3(gene name synonym)|uniprotkb:Vps35(gene name)|psi-mi:Vps35(display_short)|uniprotkb:Mem3(gene name synonym) psi-mi:vps29_mouse(display_long)|uniprotkb:Vps29(gene name)|psi-mi:Vps29(display_short)|uniprotkb:Vesicle protein sorting 29(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Kim et al. (2010) pubmed:21040701|imex:IM-23234 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-9847430|imex:IM-23234-8 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_075373.1|dip:DIP-32210N|ensembl:ENSMUSG00000031696(gene)|ensembl:ENSMUST00000034131(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005829"(cytosol)|go:"GO:0006624"(vacuolar protein processing)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0007040"(lysosome organization)|go:"GO:0007416"(synapse assembly)|go:"GO:0010008"(endosome membrane)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010821"(regulation of mitochondrion organization)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030904"(retromer complex)|go:"GO:0030906"(retromer, cargo-selective complex)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031648"(protein destabilization)|go:"GO:0031748"(D1 dopamine receptor binding)|go:"GO:0032268"(regulation of cellular protein metabolic process)|go:"GO:0032456"(endocytic recycling)|go:"GO:0032463"(negative regulation of protein homooligomerization)|go:"GO:0033365"(protein localization to organelle)|go:"GO:0036010"(protein localization to endosome)|go:"GO:0042147"(retrograde transport, endosome to Golgi)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043653"(mitochondrial fragmentation involved in apoptotic process)|go:"GO:0045056"(transcytosis)|go:"GO:0045202"(synapse)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0050882"(voluntary musculoskeletal movement)|go:"GO:0060161"(positive regulation of dopamine receptor signaling pathway)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0061357"(positive regulation of Wnt protein secretion)|go:"GO:0090141"(positive regulation of mitochondrial fission)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0090326"(positive regulation of locomotion involved in locomotory behavior)|go:"GO:0097422"(tubular endosome)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098887"(neurotransmitter receptor transport, endosome to postsynaptic membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099003"(vesicle-mediated transport in synapse)|go:"GO:0099073"(mitochondrion-derived vesicle)|go:"GO:0099074"(mitochondrion to lysosome transport)|go:"GO:0099639"(neurotransmitter receptor transport, endosome to plasma membrane)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902823"(negative regulation of late endosome to lysosome transport)|go:"GO:1902950"(regulation of dendritic spine maintenance)|go:"GO:1903181"(positive regulation of dopamine biosynthetic process)|go:"GO:1903364"(positive regulation of cellular protein catabolic process)|go:"GO:1903828"(negative regulation of protein localization)|go:"GO:1905166"(negative regulation of lysosomal protein catabolic process)|go:"GO:2000331"(regulation of terminal button organization)|interpro:IPR005378(Vacuolar protein sorting-associated protein 35)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR042491|mint:Q9EQH3|rcsb pdb:6VAB|rcsb pdb:6VAC|reactome:R-MMU-3238698 refseq:NP_062754.1|refseq:NP_001334382.1|dip:DIP-60495N|ensembl:ENSMUSG00000029462(gene)|ensembl:ENSMUST00000155671(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006896"(Golgi to vacuole transport)|go:"GO:0010008"(endosome membrane)|go:"GO:0030904"(retromer complex)|go:"GO:0030906"(retromer, cargo-selective complex)|go:"GO:0032456"(endocytic recycling)|go:"GO:0042147"(retrograde transport, endosome to Golgi)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0046872"(metal ion binding)|interpro:IPR000979(Protein of unknown function UPF0025)|interpro:IPR024654|interpro:IPR028661|interpro:IPR029052|mint:Q9QZ88|rcsb pdb:1Z2W|rcsb pdb:1Z2X|rcsb pdb:3PSN|rcsb pdb:3PSO|rcsb pdb:6TL0|rcsb pdb:6VAB|rcsb pdb:6VAC|reactome:R-MMU-3238698|go:"GO:0005768"(endosome) - - function:"Essential component of the retromer complex, a complex required to retrieve lysosomal enzyme receptors (IGF2R and M6PR) from endosomes to the trans-Golgi network. Also required to regulate transcytosis of the polymeric immunoglobulin receptor (pIgR-pIgA). Has low protein phosphatase activity towards a serine-phosphorylated peptide derived from IGF2R (in vitro) (By similarity). Has no activity towards p-nitrophenylphosphate, p-nitrophenylphosphorylcholine or phosphatidylinositlphosphates (in vitro)"|comment:mint figure legend:2|comment:CoIP in VPS26b-/- mice|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain) - 2014/10/02 2014/10/16 rogid:dK5TqSajxrGKjiNwRjeZCV519XE10090 rogid:XLAmkQXgIRvAF4JDcavWOR9CnsY10090 intact-crc:43A32B2DD1203E14|rigid:VQRb+Yegl2A9m6WeZRxUJlm7nuo false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q9EQH3 uniprotkb:P40336 intact:EBI-775825|uniprotkb:Q61123|ensembl:ENSMUSP00000034131 intact:EBI-775981|uniprotkb:Q3TGY3|uniprotkb:Q3THM5|uniprotkb:Q3TW99|uniprotkb:Q3UD54|uniprotkb:Q8C1E9|ensembl:ENSMUSP00000101087 psi-mi:vps35_mouse(display_long)|uniprotkb:Vesicle protein sorting 35(gene name synonym)|uniprotkb:Maternal-embryonic 3(gene name synonym)|uniprotkb:Vps35(gene name)|psi-mi:Vps35(display_short)|uniprotkb:Mem3(gene name synonym) psi-mi:vp26a_mouse(display_long)|uniprotkb:Vesicle protein sorting 26A(gene name synonym)|uniprotkb:H58 protein(gene name synonym)|uniprotkb:Vps26a(gene name)|psi-mi:Vps26a(display_short)|uniprotkb:Vps26(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Kim et al. (2010) pubmed:21040701|imex:IM-23234 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-9847430|imex:IM-23234-8 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_075373.1|dip:DIP-32210N|ensembl:ENSMUSG00000031696(gene)|ensembl:ENSMUST00000034131(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005829"(cytosol)|go:"GO:0006624"(vacuolar protein processing)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0007040"(lysosome organization)|go:"GO:0007416"(synapse assembly)|go:"GO:0010008"(endosome membrane)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010821"(regulation of mitochondrion organization)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030904"(retromer complex)|go:"GO:0030906"(retromer, cargo-selective complex)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031648"(protein destabilization)|go:"GO:0031748"(D1 dopamine receptor binding)|go:"GO:0032268"(regulation of cellular protein metabolic process)|go:"GO:0032456"(endocytic recycling)|go:"GO:0032463"(negative regulation of protein homooligomerization)|go:"GO:0033365"(protein localization to organelle)|go:"GO:0036010"(protein localization to endosome)|go:"GO:0042147"(retrograde transport, endosome to Golgi)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043653"(mitochondrial fragmentation involved in apoptotic process)|go:"GO:0045056"(transcytosis)|go:"GO:0045202"(synapse)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0050882"(voluntary musculoskeletal movement)|go:"GO:0060161"(positive regulation of dopamine receptor signaling pathway)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0061357"(positive regulation of Wnt protein secretion)|go:"GO:0090141"(positive regulation of mitochondrial fission)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0090326"(positive regulation of locomotion involved in locomotory behavior)|go:"GO:0097422"(tubular endosome)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098887"(neurotransmitter receptor transport, endosome to postsynaptic membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099003"(vesicle-mediated transport in synapse)|go:"GO:0099073"(mitochondrion-derived vesicle)|go:"GO:0099074"(mitochondrion to lysosome transport)|go:"GO:0099639"(neurotransmitter receptor transport, endosome to plasma membrane)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902823"(negative regulation of late endosome to lysosome transport)|go:"GO:1902950"(regulation of dendritic spine maintenance)|go:"GO:1903181"(positive regulation of dopamine biosynthetic process)|go:"GO:1903364"(positive regulation of cellular protein catabolic process)|go:"GO:1903828"(negative regulation of protein localization)|go:"GO:1905166"(negative regulation of lysosomal protein catabolic process)|go:"GO:2000331"(regulation of terminal button organization)|interpro:IPR005378(Vacuolar protein sorting-associated protein 35)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR042491|mint:Q9EQH3|rcsb pdb:6VAB|rcsb pdb:6VAC|reactome:R-MMU-3238698 refseq:NP_001106826.1|refseq:NP_598433.1|dip:DIP-32041N|ensembl:ENSMUSG00000020078(gene)|ensembl:ENSMUST00000105447(transcript)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0010008"(endosome membrane)|go:"GO:0030904"(retromer complex)|go:"GO:0030906"(retromer, cargo-selective complex)|go:"GO:0031982"(vesicle)|go:"GO:0032456"(endocytic recycling)|go:"GO:0042147"(retrograde transport, endosome to Golgi)|go:"GO:0097422"(tubular endosome)|interpro:IPR014752(Arrestin, C-terminal)|interpro:IPR028934|mint:P40336|rcsb pdb:4P2A|rcsb pdb:6VAC|reactome:R-MMU-3238698 - - - figure legend:2|comment:CoIP in VPS26b-/- mice|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain) - 2014/10/02 2014/10/16 rogid:dK5TqSajxrGKjiNwRjeZCV519XE10090 rogid:fzT+kSNk6/aqTm7hSsSbItmgyYE10090 intact-crc:43A32B2DD1203E14|rigid:VQRb+Yegl2A9m6WeZRxUJlm7nuo false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q8C0E2 uniprotkb:Q9QZ88 intact:EBI-8314940|ensembl:ENSMUSP00000034470|uniprotkb:Q8K2V3|uniprotkb:Q3TN45|intact:MINT-3253852 intact:EBI-8334188|intact:MINT-4140090|uniprotkb:Q9D107|uniprotkb:Q3UCZ0|ensembl:ENSMUSP00000121020 psi-mi:vp26b_mouse(display_long)|uniprotkb:Vps26b(gene name)|psi-mi:Vps26b(display_short)|uniprotkb:Vesicle protein sorting 26B(gene name synonym) psi-mi:vps29_mouse(display_long)|uniprotkb:Vps29(gene name)|psi-mi:Vps29(display_short)|uniprotkb:Vesicle protein sorting 29(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Kim et al. (2010) pubmed:21040701|imex:IM-23234 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-9827117|imex:IM-23234-2 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000031988(gene)|ensembl:ENSMUST00000034470(transcript)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005829"(cytosol)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0030904"(retromer complex)|go:"GO:0042147"(retrograde transport, endosome to Golgi)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0071346"(cellular response to interferon-gamma)|interpro:IPR014752(Arrestin, C-terminal)|interpro:IPR028934|mint:Q8C0E2|rcsb pdb:2R51|rcsb pdb:3LH8|rcsb pdb:3LH9|rcsb pdb:3LHA|refseq:NP_821170.1 refseq:NP_062754.1|refseq:NP_001334382.1|dip:DIP-60495N|ensembl:ENSMUSG00000029462(gene)|ensembl:ENSMUST00000155671(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006896"(Golgi to vacuole transport)|go:"GO:0010008"(endosome membrane)|go:"GO:0030904"(retromer complex)|go:"GO:0030906"(retromer, cargo-selective complex)|go:"GO:0032456"(endocytic recycling)|go:"GO:0042147"(retrograde transport, endosome to Golgi)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0046872"(metal ion binding)|interpro:IPR000979(Protein of unknown function UPF0025)|interpro:IPR024654|interpro:IPR028661|interpro:IPR029052|mint:Q9QZ88|rcsb pdb:1Z2W|rcsb pdb:1Z2X|rcsb pdb:3PSN|rcsb pdb:3PSO|rcsb pdb:6TL0|rcsb pdb:6VAB|rcsb pdb:6VAC|reactome:R-MMU-3238698|go:"GO:0005768"(endosome) - comment:mint|function:"Probable component of the retromer complex, a complex required to retrieve lysosomal enzyme receptors (IGF2R and M6PR) from endosomes to the trans-Golgi network" function:"Essential component of the retromer complex, a complex required to retrieve lysosomal enzyme receptors (IGF2R and M6PR) from endosomes to the trans-Golgi network. Also required to regulate transcytosis of the polymeric immunoglobulin receptor (pIgR-pIgA). Has low protein phosphatase activity towards a serine-phosphorylated peptide derived from IGF2R (in vitro) (By similarity). Has no activity towards p-nitrophenylphosphate, p-nitrophenylphosphorylcholine or phosphatidylinositlphosphates (in vitro)"|comment:mint figure legend:2|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain) - 2014/10/02 2014/10/16 rogid:0ldtjq7g6fEiaFTAusA8J+Xy4Qg10090 rogid:XLAmkQXgIRvAF4JDcavWOR9CnsY10090 intact-crc:4CD2ACFA65FAD253|rigid:BdSqHzHqKodB/ABIIJ4qGezudlQ false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q8C0E2 uniprotkb:Q9EQH3 intact:EBI-8314940|ensembl:ENSMUSP00000034470|uniprotkb:Q8K2V3|uniprotkb:Q3TN45|intact:MINT-3253852 intact:EBI-775825|uniprotkb:Q61123|ensembl:ENSMUSP00000034131 psi-mi:vp26b_mouse(display_long)|uniprotkb:Vps26b(gene name)|psi-mi:Vps26b(display_short)|uniprotkb:Vesicle protein sorting 26B(gene name synonym) psi-mi:vps35_mouse(display_long)|uniprotkb:Vesicle protein sorting 35(gene name synonym)|uniprotkb:Maternal-embryonic 3(gene name synonym)|uniprotkb:Vps35(gene name)|psi-mi:Vps35(display_short)|uniprotkb:Mem3(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Kim et al. (2010) pubmed:21040701|imex:IM-23234 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-9827117|imex:IM-23234-2 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000031988(gene)|ensembl:ENSMUST00000034470(transcript)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005829"(cytosol)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0030904"(retromer complex)|go:"GO:0042147"(retrograde transport, endosome to Golgi)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0071346"(cellular response to interferon-gamma)|interpro:IPR014752(Arrestin, C-terminal)|interpro:IPR028934|mint:Q8C0E2|rcsb pdb:2R51|rcsb pdb:3LH8|rcsb pdb:3LH9|rcsb pdb:3LHA|refseq:NP_821170.1 refseq:NP_075373.1|dip:DIP-32210N|ensembl:ENSMUSG00000031696(gene)|ensembl:ENSMUST00000034131(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005829"(cytosol)|go:"GO:0006624"(vacuolar protein processing)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0007040"(lysosome organization)|go:"GO:0007416"(synapse assembly)|go:"GO:0010008"(endosome membrane)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010821"(regulation of mitochondrion organization)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030904"(retromer complex)|go:"GO:0030906"(retromer, cargo-selective complex)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031648"(protein destabilization)|go:"GO:0031748"(D1 dopamine receptor binding)|go:"GO:0032268"(regulation of cellular protein metabolic process)|go:"GO:0032456"(endocytic recycling)|go:"GO:0032463"(negative regulation of protein homooligomerization)|go:"GO:0033365"(protein localization to organelle)|go:"GO:0036010"(protein localization to endosome)|go:"GO:0042147"(retrograde transport, endosome to Golgi)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043653"(mitochondrial fragmentation involved in apoptotic process)|go:"GO:0045056"(transcytosis)|go:"GO:0045202"(synapse)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0050882"(voluntary musculoskeletal movement)|go:"GO:0060161"(positive regulation of dopamine receptor signaling pathway)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0061357"(positive regulation of Wnt protein secretion)|go:"GO:0090141"(positive regulation of mitochondrial fission)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0090326"(positive regulation of locomotion involved in locomotory behavior)|go:"GO:0097422"(tubular endosome)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098887"(neurotransmitter receptor transport, endosome to postsynaptic membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099003"(vesicle-mediated transport in synapse)|go:"GO:0099073"(mitochondrion-derived vesicle)|go:"GO:0099074"(mitochondrion to lysosome transport)|go:"GO:0099639"(neurotransmitter receptor transport, endosome to plasma membrane)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902823"(negative regulation of late endosome to lysosome transport)|go:"GO:1902950"(regulation of dendritic spine maintenance)|go:"GO:1903181"(positive regulation of dopamine biosynthetic process)|go:"GO:1903364"(positive regulation of cellular protein catabolic process)|go:"GO:1903828"(negative regulation of protein localization)|go:"GO:1905166"(negative regulation of lysosomal protein catabolic process)|go:"GO:2000331"(regulation of terminal button organization)|interpro:IPR005378(Vacuolar protein sorting-associated protein 35)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR042491|mint:Q9EQH3|rcsb pdb:6VAB|rcsb pdb:6VAC|reactome:R-MMU-3238698 - comment:mint|function:"Probable component of the retromer complex, a complex required to retrieve lysosomal enzyme receptors (IGF2R and M6PR) from endosomes to the trans-Golgi network" - figure legend:2|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain) - 2014/10/02 2014/10/16 rogid:0ldtjq7g6fEiaFTAusA8J+Xy4Qg10090 rogid:dK5TqSajxrGKjiNwRjeZCV519XE10090 intact-crc:4CD2ACFA65FAD253|rigid:BdSqHzHqKodB/ABIIJ4qGezudlQ false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q9EQH3 uniprotkb:Q9QZ88 intact:EBI-775825|uniprotkb:Q61123|ensembl:ENSMUSP00000034131 intact:EBI-8334188|intact:MINT-4140090|uniprotkb:Q9D107|uniprotkb:Q3UCZ0|ensembl:ENSMUSP00000121020 psi-mi:vps35_mouse(display_long)|uniprotkb:Vesicle protein sorting 35(gene name synonym)|uniprotkb:Maternal-embryonic 3(gene name synonym)|uniprotkb:Vps35(gene name)|psi-mi:Vps35(display_short)|uniprotkb:Mem3(gene name synonym) psi-mi:vps29_mouse(display_long)|uniprotkb:Vps29(gene name)|psi-mi:Vps29(display_short)|uniprotkb:Vesicle protein sorting 29(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Kim et al. (2010) pubmed:21040701|imex:IM-23234 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-9827129|imex:IM-23234-4 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_075373.1|dip:DIP-32210N|ensembl:ENSMUSG00000031696(gene)|ensembl:ENSMUST00000034131(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005829"(cytosol)|go:"GO:0006624"(vacuolar protein processing)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0007040"(lysosome organization)|go:"GO:0007416"(synapse assembly)|go:"GO:0010008"(endosome membrane)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010821"(regulation of mitochondrion organization)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030904"(retromer complex)|go:"GO:0030906"(retromer, cargo-selective complex)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031648"(protein destabilization)|go:"GO:0031748"(D1 dopamine receptor binding)|go:"GO:0032268"(regulation of cellular protein metabolic process)|go:"GO:0032456"(endocytic recycling)|go:"GO:0032463"(negative regulation of protein homooligomerization)|go:"GO:0033365"(protein localization to organelle)|go:"GO:0036010"(protein localization to endosome)|go:"GO:0042147"(retrograde transport, endosome to Golgi)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043653"(mitochondrial fragmentation involved in apoptotic process)|go:"GO:0045056"(transcytosis)|go:"GO:0045202"(synapse)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0050882"(voluntary musculoskeletal movement)|go:"GO:0060161"(positive regulation of dopamine receptor signaling pathway)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0061357"(positive regulation of Wnt protein secretion)|go:"GO:0090141"(positive regulation of mitochondrial fission)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0090326"(positive regulation of locomotion involved in locomotory behavior)|go:"GO:0097422"(tubular endosome)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098887"(neurotransmitter receptor transport, endosome to postsynaptic membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099003"(vesicle-mediated transport in synapse)|go:"GO:0099073"(mitochondrion-derived vesicle)|go:"GO:0099074"(mitochondrion to lysosome transport)|go:"GO:0099639"(neurotransmitter receptor transport, endosome to plasma membrane)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902823"(negative regulation of late endosome to lysosome transport)|go:"GO:1902950"(regulation of dendritic spine maintenance)|go:"GO:1903181"(positive regulation of dopamine biosynthetic process)|go:"GO:1903364"(positive regulation of cellular protein catabolic process)|go:"GO:1903828"(negative regulation of protein localization)|go:"GO:1905166"(negative regulation of lysosomal protein catabolic process)|go:"GO:2000331"(regulation of terminal button organization)|interpro:IPR005378(Vacuolar protein sorting-associated protein 35)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR042491|mint:Q9EQH3|rcsb pdb:6VAB|rcsb pdb:6VAC|reactome:R-MMU-3238698 refseq:NP_062754.1|refseq:NP_001334382.1|dip:DIP-60495N|ensembl:ENSMUSG00000029462(gene)|ensembl:ENSMUST00000155671(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006896"(Golgi to vacuole transport)|go:"GO:0010008"(endosome membrane)|go:"GO:0030904"(retromer complex)|go:"GO:0030906"(retromer, cargo-selective complex)|go:"GO:0032456"(endocytic recycling)|go:"GO:0042147"(retrograde transport, endosome to Golgi)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0046872"(metal ion binding)|interpro:IPR000979(Protein of unknown function UPF0025)|interpro:IPR024654|interpro:IPR028661|interpro:IPR029052|mint:Q9QZ88|rcsb pdb:1Z2W|rcsb pdb:1Z2X|rcsb pdb:3PSN|rcsb pdb:3PSO|rcsb pdb:6TL0|rcsb pdb:6VAB|rcsb pdb:6VAC|reactome:R-MMU-3238698|go:"GO:0005768"(endosome) - - function:"Essential component of the retromer complex, a complex required to retrieve lysosomal enzyme receptors (IGF2R and M6PR) from endosomes to the trans-Golgi network. Also required to regulate transcytosis of the polymeric immunoglobulin receptor (pIgR-pIgA). Has low protein phosphatase activity towards a serine-phosphorylated peptide derived from IGF2R (in vitro) (By similarity). Has no activity towards p-nitrophenylphosphate, p-nitrophenylphosphorylcholine or phosphatidylinositlphosphates (in vitro)"|comment:mint figure legend:2|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain) - 2014/10/02 2014/10/16 rogid:dK5TqSajxrGKjiNwRjeZCV519XE10090 rogid:XLAmkQXgIRvAF4JDcavWOR9CnsY10090 intact-crc:AEAEDE2CB77137F8|rigid:fue7+3ZttyDmJJ271UVuiduvcbM false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q9EQH3 uniprotkb:Q8C0E2 intact:EBI-775825|uniprotkb:Q61123|ensembl:ENSMUSP00000034131 intact:EBI-8314940|ensembl:ENSMUSP00000034470|uniprotkb:Q8K2V3|uniprotkb:Q3TN45|intact:MINT-3253852 psi-mi:vps35_mouse(display_long)|uniprotkb:Vesicle protein sorting 35(gene name synonym)|uniprotkb:Maternal-embryonic 3(gene name synonym)|uniprotkb:Vps35(gene name)|psi-mi:Vps35(display_short)|uniprotkb:Mem3(gene name synonym) psi-mi:vp26b_mouse(display_long)|uniprotkb:Vps26b(gene name)|psi-mi:Vps26b(display_short)|uniprotkb:Vesicle protein sorting 26B(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Kim et al. (2010) pubmed:21040701|imex:IM-23234 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-9827129|imex:IM-23234-4 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_075373.1|dip:DIP-32210N|ensembl:ENSMUSG00000031696(gene)|ensembl:ENSMUST00000034131(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005829"(cytosol)|go:"GO:0006624"(vacuolar protein processing)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0007040"(lysosome organization)|go:"GO:0007416"(synapse assembly)|go:"GO:0010008"(endosome membrane)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010821"(regulation of mitochondrion organization)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030904"(retromer complex)|go:"GO:0030906"(retromer, cargo-selective complex)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031648"(protein destabilization)|go:"GO:0031748"(D1 dopamine receptor binding)|go:"GO:0032268"(regulation of cellular protein metabolic process)|go:"GO:0032456"(endocytic recycling)|go:"GO:0032463"(negative regulation of protein homooligomerization)|go:"GO:0033365"(protein localization to organelle)|go:"GO:0036010"(protein localization to endosome)|go:"GO:0042147"(retrograde transport, endosome to Golgi)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043653"(mitochondrial fragmentation involved in apoptotic process)|go:"GO:0045056"(transcytosis)|go:"GO:0045202"(synapse)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0050882"(voluntary musculoskeletal movement)|go:"GO:0060161"(positive regulation of dopamine receptor signaling pathway)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0061357"(positive regulation of Wnt protein secretion)|go:"GO:0090141"(positive regulation of mitochondrial fission)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0090326"(positive regulation of locomotion involved in locomotory behavior)|go:"GO:0097422"(tubular endosome)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098887"(neurotransmitter receptor transport, endosome to postsynaptic membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099003"(vesicle-mediated transport in synapse)|go:"GO:0099073"(mitochondrion-derived vesicle)|go:"GO:0099074"(mitochondrion to lysosome transport)|go:"GO:0099639"(neurotransmitter receptor transport, endosome to plasma membrane)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902823"(negative regulation of late endosome to lysosome transport)|go:"GO:1902950"(regulation of dendritic spine maintenance)|go:"GO:1903181"(positive regulation of dopamine biosynthetic process)|go:"GO:1903364"(positive regulation of cellular protein catabolic process)|go:"GO:1903828"(negative regulation of protein localization)|go:"GO:1905166"(negative regulation of lysosomal protein catabolic process)|go:"GO:2000331"(regulation of terminal button organization)|interpro:IPR005378(Vacuolar protein sorting-associated protein 35)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR042491|mint:Q9EQH3|rcsb pdb:6VAB|rcsb pdb:6VAC|reactome:R-MMU-3238698 ensembl:ENSMUSG00000031988(gene)|ensembl:ENSMUST00000034470(transcript)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005829"(cytosol)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0030904"(retromer complex)|go:"GO:0042147"(retrograde transport, endosome to Golgi)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0071346"(cellular response to interferon-gamma)|interpro:IPR014752(Arrestin, C-terminal)|interpro:IPR028934|mint:Q8C0E2|rcsb pdb:2R51|rcsb pdb:3LH8|rcsb pdb:3LH9|rcsb pdb:3LHA|refseq:NP_821170.1 - - comment:mint|function:"Probable component of the retromer complex, a complex required to retrieve lysosomal enzyme receptors (IGF2R and M6PR) from endosomes to the trans-Golgi network" figure legend:2|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain) - 2014/10/02 2014/10/16 rogid:dK5TqSajxrGKjiNwRjeZCV519XE10090 rogid:0ldtjq7g6fEiaFTAusA8J+Xy4Qg10090 intact-crc:AEAEDE2CB77137F8|rigid:fue7+3ZttyDmJJ271UVuiduvcbM false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q9EQH3 uniprotkb:P40336 intact:EBI-775825|uniprotkb:Q61123|ensembl:ENSMUSP00000034131 intact:EBI-775981|uniprotkb:Q3TGY3|uniprotkb:Q3THM5|uniprotkb:Q3TW99|uniprotkb:Q3UD54|uniprotkb:Q8C1E9|ensembl:ENSMUSP00000101087 psi-mi:vps35_mouse(display_long)|uniprotkb:Vesicle protein sorting 35(gene name synonym)|uniprotkb:Maternal-embryonic 3(gene name synonym)|uniprotkb:Vps35(gene name)|psi-mi:Vps35(display_short)|uniprotkb:Mem3(gene name synonym) psi-mi:vp26a_mouse(display_long)|uniprotkb:Vesicle protein sorting 26A(gene name synonym)|uniprotkb:H58 protein(gene name synonym)|uniprotkb:Vps26a(gene name)|psi-mi:Vps26a(display_short)|uniprotkb:Vps26(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Kim et al. (2010) pubmed:21040701|imex:IM-23234 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-9827129|imex:IM-23234-4 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_075373.1|dip:DIP-32210N|ensembl:ENSMUSG00000031696(gene)|ensembl:ENSMUST00000034131(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005829"(cytosol)|go:"GO:0006624"(vacuolar protein processing)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0007040"(lysosome organization)|go:"GO:0007416"(synapse assembly)|go:"GO:0010008"(endosome membrane)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010821"(regulation of mitochondrion organization)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030904"(retromer complex)|go:"GO:0030906"(retromer, cargo-selective complex)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031648"(protein destabilization)|go:"GO:0031748"(D1 dopamine receptor binding)|go:"GO:0032268"(regulation of cellular protein metabolic process)|go:"GO:0032456"(endocytic recycling)|go:"GO:0032463"(negative regulation of protein homooligomerization)|go:"GO:0033365"(protein localization to organelle)|go:"GO:0036010"(protein localization to endosome)|go:"GO:0042147"(retrograde transport, endosome to Golgi)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043653"(mitochondrial fragmentation involved in apoptotic process)|go:"GO:0045056"(transcytosis)|go:"GO:0045202"(synapse)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0050882"(voluntary musculoskeletal movement)|go:"GO:0060161"(positive regulation of dopamine receptor signaling pathway)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0061357"(positive regulation of Wnt protein secretion)|go:"GO:0090141"(positive regulation of mitochondrial fission)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0090326"(positive regulation of locomotion involved in locomotory behavior)|go:"GO:0097422"(tubular endosome)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098887"(neurotransmitter receptor transport, endosome to postsynaptic membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099003"(vesicle-mediated transport in synapse)|go:"GO:0099073"(mitochondrion-derived vesicle)|go:"GO:0099074"(mitochondrion to lysosome transport)|go:"GO:0099639"(neurotransmitter receptor transport, endosome to plasma membrane)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902823"(negative regulation of late endosome to lysosome transport)|go:"GO:1902950"(regulation of dendritic spine maintenance)|go:"GO:1903181"(positive regulation of dopamine biosynthetic process)|go:"GO:1903364"(positive regulation of cellular protein catabolic process)|go:"GO:1903828"(negative regulation of protein localization)|go:"GO:1905166"(negative regulation of lysosomal protein catabolic process)|go:"GO:2000331"(regulation of terminal button organization)|interpro:IPR005378(Vacuolar protein sorting-associated protein 35)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR042491|mint:Q9EQH3|rcsb pdb:6VAB|rcsb pdb:6VAC|reactome:R-MMU-3238698 refseq:NP_001106826.1|refseq:NP_598433.1|dip:DIP-32041N|ensembl:ENSMUSG00000020078(gene)|ensembl:ENSMUST00000105447(transcript)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0010008"(endosome membrane)|go:"GO:0030904"(retromer complex)|go:"GO:0030906"(retromer, cargo-selective complex)|go:"GO:0031982"(vesicle)|go:"GO:0032456"(endocytic recycling)|go:"GO:0042147"(retrograde transport, endosome to Golgi)|go:"GO:0097422"(tubular endosome)|interpro:IPR014752(Arrestin, C-terminal)|interpro:IPR028934|mint:P40336|rcsb pdb:4P2A|rcsb pdb:6VAC|reactome:R-MMU-3238698 - - - figure legend:2|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain) - 2014/10/02 2014/10/16 rogid:dK5TqSajxrGKjiNwRjeZCV519XE10090 rogid:fzT+kSNk6/aqTm7hSsSbItmgyYE10090 intact-crc:AEAEDE2CB77137F8|rigid:fue7+3ZttyDmJJ271UVuiduvcbM false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q9QZ88 uniprotkb:Q8C0E2 intact:EBI-8334188|intact:MINT-4140090|uniprotkb:Q9D107|uniprotkb:Q3UCZ0|ensembl:ENSMUSP00000121020 intact:EBI-8314940|ensembl:ENSMUSP00000034470|uniprotkb:Q8K2V3|uniprotkb:Q3TN45|intact:MINT-3253852 psi-mi:vps29_mouse(display_long)|uniprotkb:Vps29(gene name)|psi-mi:Vps29(display_short)|uniprotkb:Vesicle protein sorting 29(gene name synonym) psi-mi:vp26b_mouse(display_long)|uniprotkb:Vps26b(gene name)|psi-mi:Vps26b(display_short)|uniprotkb:Vesicle protein sorting 26B(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Kim et al. (2010) pubmed:21040701|imex:IM-23234 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-9827122|imex:IM-23234-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_062754.1|refseq:NP_001334382.1|dip:DIP-60495N|ensembl:ENSMUSG00000029462(gene)|ensembl:ENSMUST00000155671(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006896"(Golgi to vacuole transport)|go:"GO:0010008"(endosome membrane)|go:"GO:0030904"(retromer complex)|go:"GO:0030906"(retromer, cargo-selective complex)|go:"GO:0032456"(endocytic recycling)|go:"GO:0042147"(retrograde transport, endosome to Golgi)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0046872"(metal ion binding)|interpro:IPR000979(Protein of unknown function UPF0025)|interpro:IPR024654|interpro:IPR028661|interpro:IPR029052|mint:Q9QZ88|rcsb pdb:1Z2W|rcsb pdb:1Z2X|rcsb pdb:3PSN|rcsb pdb:3PSO|rcsb pdb:6TL0|rcsb pdb:6VAB|rcsb pdb:6VAC|reactome:R-MMU-3238698|go:"GO:0005768"(endosome) ensembl:ENSMUSG00000031988(gene)|ensembl:ENSMUST00000034470(transcript)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005829"(cytosol)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0030904"(retromer complex)|go:"GO:0042147"(retrograde transport, endosome to Golgi)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0071346"(cellular response to interferon-gamma)|interpro:IPR014752(Arrestin, C-terminal)|interpro:IPR028934|mint:Q8C0E2|rcsb pdb:2R51|rcsb pdb:3LH8|rcsb pdb:3LH9|rcsb pdb:3LHA|refseq:NP_821170.1 - function:"Essential component of the retromer complex, a complex required to retrieve lysosomal enzyme receptors (IGF2R and M6PR) from endosomes to the trans-Golgi network. Also required to regulate transcytosis of the polymeric immunoglobulin receptor (pIgR-pIgA). Has low protein phosphatase activity towards a serine-phosphorylated peptide derived from IGF2R (in vitro) (By similarity). Has no activity towards p-nitrophenylphosphate, p-nitrophenylphosphorylcholine or phosphatidylinositlphosphates (in vitro)"|comment:mint comment:mint|function:"Probable component of the retromer complex, a complex required to retrieve lysosomal enzyme receptors (IGF2R and M6PR) from endosomes to the trans-Golgi network" figure legend:2|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain) - 2014/10/02 2014/10/16 rogid:XLAmkQXgIRvAF4JDcavWOR9CnsY10090 rogid:0ldtjq7g6fEiaFTAusA8J+Xy4Qg10090 intact-crc:94CD8C21E2B53214|rigid:fue7+3ZttyDmJJ271UVuiduvcbM false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q9QZ88 uniprotkb:P40336 intact:EBI-8334188|intact:MINT-4140090|uniprotkb:Q9D107|uniprotkb:Q3UCZ0|ensembl:ENSMUSP00000121020 intact:EBI-775981|uniprotkb:Q3TGY3|uniprotkb:Q3THM5|uniprotkb:Q3TW99|uniprotkb:Q3UD54|uniprotkb:Q8C1E9|ensembl:ENSMUSP00000101087 psi-mi:vps29_mouse(display_long)|uniprotkb:Vps29(gene name)|psi-mi:Vps29(display_short)|uniprotkb:Vesicle protein sorting 29(gene name synonym) psi-mi:vp26a_mouse(display_long)|uniprotkb:Vesicle protein sorting 26A(gene name synonym)|uniprotkb:H58 protein(gene name synonym)|uniprotkb:Vps26a(gene name)|psi-mi:Vps26a(display_short)|uniprotkb:Vps26(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Kim et al. (2010) pubmed:21040701|imex:IM-23234 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-9827122|imex:IM-23234-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_062754.1|refseq:NP_001334382.1|dip:DIP-60495N|ensembl:ENSMUSG00000029462(gene)|ensembl:ENSMUST00000155671(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006896"(Golgi to vacuole transport)|go:"GO:0010008"(endosome membrane)|go:"GO:0030904"(retromer complex)|go:"GO:0030906"(retromer, cargo-selective complex)|go:"GO:0032456"(endocytic recycling)|go:"GO:0042147"(retrograde transport, endosome to Golgi)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0046872"(metal ion binding)|interpro:IPR000979(Protein of unknown function UPF0025)|interpro:IPR024654|interpro:IPR028661|interpro:IPR029052|mint:Q9QZ88|rcsb pdb:1Z2W|rcsb pdb:1Z2X|rcsb pdb:3PSN|rcsb pdb:3PSO|rcsb pdb:6TL0|rcsb pdb:6VAB|rcsb pdb:6VAC|reactome:R-MMU-3238698|go:"GO:0005768"(endosome) refseq:NP_001106826.1|refseq:NP_598433.1|dip:DIP-32041N|ensembl:ENSMUSG00000020078(gene)|ensembl:ENSMUST00000105447(transcript)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0010008"(endosome membrane)|go:"GO:0030904"(retromer complex)|go:"GO:0030906"(retromer, cargo-selective complex)|go:"GO:0031982"(vesicle)|go:"GO:0032456"(endocytic recycling)|go:"GO:0042147"(retrograde transport, endosome to Golgi)|go:"GO:0097422"(tubular endosome)|interpro:IPR014752(Arrestin, C-terminal)|interpro:IPR028934|mint:P40336|rcsb pdb:4P2A|rcsb pdb:6VAC|reactome:R-MMU-3238698 - function:"Essential component of the retromer complex, a complex required to retrieve lysosomal enzyme receptors (IGF2R and M6PR) from endosomes to the trans-Golgi network. Also required to regulate transcytosis of the polymeric immunoglobulin receptor (pIgR-pIgA). Has low protein phosphatase activity towards a serine-phosphorylated peptide derived from IGF2R (in vitro) (By similarity). Has no activity towards p-nitrophenylphosphate, p-nitrophenylphosphorylcholine or phosphatidylinositlphosphates (in vitro)"|comment:mint - figure legend:2|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain) - 2014/10/02 2014/10/16 rogid:XLAmkQXgIRvAF4JDcavWOR9CnsY10090 rogid:fzT+kSNk6/aqTm7hSsSbItmgyYE10090 intact-crc:94CD8C21E2B53214|rigid:fue7+3ZttyDmJJ271UVuiduvcbM false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q9QZ88 uniprotkb:Q9EQH3 intact:EBI-8334188|intact:MINT-4140090|uniprotkb:Q9D107|uniprotkb:Q3UCZ0|ensembl:ENSMUSP00000121020 intact:EBI-775825|uniprotkb:Q61123|ensembl:ENSMUSP00000034131 psi-mi:vps29_mouse(display_long)|uniprotkb:Vps29(gene name)|psi-mi:Vps29(display_short)|uniprotkb:Vesicle protein sorting 29(gene name synonym) psi-mi:vps35_mouse(display_long)|uniprotkb:Vesicle protein sorting 35(gene name synonym)|uniprotkb:Maternal-embryonic 3(gene name synonym)|uniprotkb:Vps35(gene name)|psi-mi:Vps35(display_short)|uniprotkb:Mem3(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Kim et al. (2010) pubmed:21040701|imex:IM-23234 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-9827122|imex:IM-23234-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_062754.1|refseq:NP_001334382.1|dip:DIP-60495N|ensembl:ENSMUSG00000029462(gene)|ensembl:ENSMUST00000155671(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006896"(Golgi to vacuole transport)|go:"GO:0010008"(endosome membrane)|go:"GO:0030904"(retromer complex)|go:"GO:0030906"(retromer, cargo-selective complex)|go:"GO:0032456"(endocytic recycling)|go:"GO:0042147"(retrograde transport, endosome to Golgi)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0046872"(metal ion binding)|interpro:IPR000979(Protein of unknown function UPF0025)|interpro:IPR024654|interpro:IPR028661|interpro:IPR029052|mint:Q9QZ88|rcsb pdb:1Z2W|rcsb pdb:1Z2X|rcsb pdb:3PSN|rcsb pdb:3PSO|rcsb pdb:6TL0|rcsb pdb:6VAB|rcsb pdb:6VAC|reactome:R-MMU-3238698|go:"GO:0005768"(endosome) refseq:NP_075373.1|dip:DIP-32210N|ensembl:ENSMUSG00000031696(gene)|ensembl:ENSMUST00000034131(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005829"(cytosol)|go:"GO:0006624"(vacuolar protein processing)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0007040"(lysosome organization)|go:"GO:0007416"(synapse assembly)|go:"GO:0010008"(endosome membrane)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010821"(regulation of mitochondrion organization)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030904"(retromer complex)|go:"GO:0030906"(retromer, cargo-selective complex)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031648"(protein destabilization)|go:"GO:0031748"(D1 dopamine receptor binding)|go:"GO:0032268"(regulation of cellular protein metabolic process)|go:"GO:0032456"(endocytic recycling)|go:"GO:0032463"(negative regulation of protein homooligomerization)|go:"GO:0033365"(protein localization to organelle)|go:"GO:0036010"(protein localization to endosome)|go:"GO:0042147"(retrograde transport, endosome to Golgi)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043653"(mitochondrial fragmentation involved in apoptotic process)|go:"GO:0045056"(transcytosis)|go:"GO:0045202"(synapse)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0050882"(voluntary musculoskeletal movement)|go:"GO:0060161"(positive regulation of dopamine receptor signaling pathway)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0061357"(positive regulation of Wnt protein secretion)|go:"GO:0090141"(positive regulation of mitochondrial fission)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0090326"(positive regulation of locomotion involved in locomotory behavior)|go:"GO:0097422"(tubular endosome)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098887"(neurotransmitter receptor transport, endosome to postsynaptic membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099003"(vesicle-mediated transport in synapse)|go:"GO:0099073"(mitochondrion-derived vesicle)|go:"GO:0099074"(mitochondrion to lysosome transport)|go:"GO:0099639"(neurotransmitter receptor transport, endosome to plasma membrane)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902823"(negative regulation of late endosome to lysosome transport)|go:"GO:1902950"(regulation of dendritic spine maintenance)|go:"GO:1903181"(positive regulation of dopamine biosynthetic process)|go:"GO:1903364"(positive regulation of cellular protein catabolic process)|go:"GO:1903828"(negative regulation of protein localization)|go:"GO:1905166"(negative regulation of lysosomal protein catabolic process)|go:"GO:2000331"(regulation of terminal button organization)|interpro:IPR005378(Vacuolar protein sorting-associated protein 35)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR042491|mint:Q9EQH3|rcsb pdb:6VAB|rcsb pdb:6VAC|reactome:R-MMU-3238698 - function:"Essential component of the retromer complex, a complex required to retrieve lysosomal enzyme receptors (IGF2R and M6PR) from endosomes to the trans-Golgi network. Also required to regulate transcytosis of the polymeric immunoglobulin receptor (pIgR-pIgA). Has low protein phosphatase activity towards a serine-phosphorylated peptide derived from IGF2R (in vitro) (By similarity). Has no activity towards p-nitrophenylphosphate, p-nitrophenylphosphorylcholine or phosphatidylinositlphosphates (in vitro)"|comment:mint - figure legend:2|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain) - 2014/10/02 2014/10/16 rogid:XLAmkQXgIRvAF4JDcavWOR9CnsY10090 rogid:dK5TqSajxrGKjiNwRjeZCV519XE10090 intact-crc:94CD8C21E2B53214|rigid:fue7+3ZttyDmJJ271UVuiduvcbM false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:P40336 uniprotkb:Q9QZ88 intact:EBI-775981|uniprotkb:Q3TGY3|uniprotkb:Q3THM5|uniprotkb:Q3TW99|uniprotkb:Q3UD54|uniprotkb:Q8C1E9|ensembl:ENSMUSP00000101087 intact:EBI-8334188|intact:MINT-4140090|uniprotkb:Q9D107|uniprotkb:Q3UCZ0|ensembl:ENSMUSP00000121020 psi-mi:vp26a_mouse(display_long)|uniprotkb:Vesicle protein sorting 26A(gene name synonym)|uniprotkb:H58 protein(gene name synonym)|uniprotkb:Vps26a(gene name)|psi-mi:Vps26a(display_short)|uniprotkb:Vps26(gene name synonym) psi-mi:vps29_mouse(display_long)|uniprotkb:Vps29(gene name)|psi-mi:Vps29(display_short)|uniprotkb:Vesicle protein sorting 29(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Kim et al. (2010) pubmed:21040701|imex:IM-23234 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-9827112|imex:IM-23234-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001106826.1|refseq:NP_598433.1|dip:DIP-32041N|ensembl:ENSMUSG00000020078(gene)|ensembl:ENSMUST00000105447(transcript)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0010008"(endosome membrane)|go:"GO:0030904"(retromer complex)|go:"GO:0030906"(retromer, cargo-selective complex)|go:"GO:0031982"(vesicle)|go:"GO:0032456"(endocytic recycling)|go:"GO:0042147"(retrograde transport, endosome to Golgi)|go:"GO:0097422"(tubular endosome)|interpro:IPR014752(Arrestin, C-terminal)|interpro:IPR028934|mint:P40336|rcsb pdb:4P2A|rcsb pdb:6VAC|reactome:R-MMU-3238698 refseq:NP_062754.1|refseq:NP_001334382.1|dip:DIP-60495N|ensembl:ENSMUSG00000029462(gene)|ensembl:ENSMUST00000155671(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006896"(Golgi to vacuole transport)|go:"GO:0010008"(endosome membrane)|go:"GO:0030904"(retromer complex)|go:"GO:0030906"(retromer, cargo-selective complex)|go:"GO:0032456"(endocytic recycling)|go:"GO:0042147"(retrograde transport, endosome to Golgi)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0046872"(metal ion binding)|interpro:IPR000979(Protein of unknown function UPF0025)|interpro:IPR024654|interpro:IPR028661|interpro:IPR029052|mint:Q9QZ88|rcsb pdb:1Z2W|rcsb pdb:1Z2X|rcsb pdb:3PSN|rcsb pdb:3PSO|rcsb pdb:6TL0|rcsb pdb:6VAB|rcsb pdb:6VAC|reactome:R-MMU-3238698|go:"GO:0005768"(endosome) - - function:"Essential component of the retromer complex, a complex required to retrieve lysosomal enzyme receptors (IGF2R and M6PR) from endosomes to the trans-Golgi network. Also required to regulate transcytosis of the polymeric immunoglobulin receptor (pIgR-pIgA). Has low protein phosphatase activity towards a serine-phosphorylated peptide derived from IGF2R (in vitro) (By similarity). Has no activity towards p-nitrophenylphosphate, p-nitrophenylphosphorylcholine or phosphatidylinositlphosphates (in vitro)"|comment:mint figure legend:2|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain) - 2014/10/02 2014/10/16 rogid:fzT+kSNk6/aqTm7hSsSbItmgyYE10090 rogid:XLAmkQXgIRvAF4JDcavWOR9CnsY10090 intact-crc:90E6A2B9B2CC8173|rigid:VQRb+Yegl2A9m6WeZRxUJlm7nuo false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:P40336 uniprotkb:Q9EQH3 intact:EBI-775981|uniprotkb:Q3TGY3|uniprotkb:Q3THM5|uniprotkb:Q3TW99|uniprotkb:Q3UD54|uniprotkb:Q8C1E9|ensembl:ENSMUSP00000101087 intact:EBI-775825|uniprotkb:Q61123|ensembl:ENSMUSP00000034131 psi-mi:vp26a_mouse(display_long)|uniprotkb:Vesicle protein sorting 26A(gene name synonym)|uniprotkb:H58 protein(gene name synonym)|uniprotkb:Vps26a(gene name)|psi-mi:Vps26a(display_short)|uniprotkb:Vps26(gene name synonym) psi-mi:vps35_mouse(display_long)|uniprotkb:Vesicle protein sorting 35(gene name synonym)|uniprotkb:Maternal-embryonic 3(gene name synonym)|uniprotkb:Vps35(gene name)|psi-mi:Vps35(display_short)|uniprotkb:Mem3(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Kim et al. (2010) pubmed:21040701|imex:IM-23234 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-9827112|imex:IM-23234-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001106826.1|refseq:NP_598433.1|dip:DIP-32041N|ensembl:ENSMUSG00000020078(gene)|ensembl:ENSMUST00000105447(transcript)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0010008"(endosome membrane)|go:"GO:0030904"(retromer complex)|go:"GO:0030906"(retromer, cargo-selective complex)|go:"GO:0031982"(vesicle)|go:"GO:0032456"(endocytic recycling)|go:"GO:0042147"(retrograde transport, endosome to Golgi)|go:"GO:0097422"(tubular endosome)|interpro:IPR014752(Arrestin, C-terminal)|interpro:IPR028934|mint:P40336|rcsb pdb:4P2A|rcsb pdb:6VAC|reactome:R-MMU-3238698 refseq:NP_075373.1|dip:DIP-32210N|ensembl:ENSMUSG00000031696(gene)|ensembl:ENSMUST00000034131(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005829"(cytosol)|go:"GO:0006624"(vacuolar protein processing)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0007040"(lysosome organization)|go:"GO:0007416"(synapse assembly)|go:"GO:0010008"(endosome membrane)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010821"(regulation of mitochondrion organization)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030904"(retromer complex)|go:"GO:0030906"(retromer, cargo-selective complex)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031648"(protein destabilization)|go:"GO:0031748"(D1 dopamine receptor binding)|go:"GO:0032268"(regulation of cellular protein metabolic process)|go:"GO:0032456"(endocytic recycling)|go:"GO:0032463"(negative regulation of protein homooligomerization)|go:"GO:0033365"(protein localization to organelle)|go:"GO:0036010"(protein localization to endosome)|go:"GO:0042147"(retrograde transport, endosome to Golgi)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043653"(mitochondrial fragmentation involved in apoptotic process)|go:"GO:0045056"(transcytosis)|go:"GO:0045202"(synapse)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0050882"(voluntary musculoskeletal movement)|go:"GO:0060161"(positive regulation of dopamine receptor signaling pathway)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0061357"(positive regulation of Wnt protein secretion)|go:"GO:0090141"(positive regulation of mitochondrial fission)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0090326"(positive regulation of locomotion involved in locomotory behavior)|go:"GO:0097422"(tubular endosome)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098887"(neurotransmitter receptor transport, endosome to postsynaptic membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099003"(vesicle-mediated transport in synapse)|go:"GO:0099073"(mitochondrion-derived vesicle)|go:"GO:0099074"(mitochondrion to lysosome transport)|go:"GO:0099639"(neurotransmitter receptor transport, endosome to plasma membrane)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902823"(negative regulation of late endosome to lysosome transport)|go:"GO:1902950"(regulation of dendritic spine maintenance)|go:"GO:1903181"(positive regulation of dopamine biosynthetic process)|go:"GO:1903364"(positive regulation of cellular protein catabolic process)|go:"GO:1903828"(negative regulation of protein localization)|go:"GO:1905166"(negative regulation of lysosomal protein catabolic process)|go:"GO:2000331"(regulation of terminal button organization)|interpro:IPR005378(Vacuolar protein sorting-associated protein 35)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR042491|mint:Q9EQH3|rcsb pdb:6VAB|rcsb pdb:6VAC|reactome:R-MMU-3238698 - - - figure legend:2|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain) - 2014/10/02 2014/10/16 rogid:fzT+kSNk6/aqTm7hSsSbItmgyYE10090 rogid:dK5TqSajxrGKjiNwRjeZCV519XE10090 intact-crc:90E6A2B9B2CC8173|rigid:VQRb+Yegl2A9m6WeZRxUJlm7nuo false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q6PHU5 uniprotkb:Q8C0E2 intact:EBI-6985663|ensembl:ENSMUSP00000099692|uniprotkb:Q9QXW6|uniprotkb:A2AEE8|uniprotkb:Q8K043|uniprotkb:Q3UHE2|intact:MINT-4130555 intact:EBI-8314940|ensembl:ENSMUSP00000034470|uniprotkb:Q8K2V3|uniprotkb:Q3TN45|intact:MINT-3253852 psi-mi:sort_mouse(display_long)|uniprotkb:Sort1(gene name)|psi-mi:Sort1(display_short)|uniprotkb:Neurotensin receptor 3(gene name synonym) psi-mi:vp26b_mouse(display_long)|uniprotkb:Vps26b(gene name)|psi-mi:Vps26b(display_short)|uniprotkb:Vesicle protein sorting 26B(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Kim et al. (2010) pubmed:21040701|imex:IM-23234 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-9827151|imex:IM-23234-6 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000068747(gene)|ensembl:ENSMUST00000102632(transcript)|go:"GO:0001503"(ossification)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005769"(early endosome)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006622"(protein targeting to lysosome)|rcsb pdb:5ZNN|reactome:R-MMU-432722|go:"GO:0006892"(post-Golgi vesicle-mediated transport)|go:"GO:0006895"(Golgi to endosome transport)|go:"GO:0006897"(endocytosis)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007218"(neuropeptide signaling pathway)|go:"GO:0008333"(endosome to lysosome transport)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0009986"(cell surface)|go:"GO:0010008"(endosome membrane)|go:"GO:0010465"(nerve growth factor receptor activity)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0014902"(myotube differentiation)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016050"(vesicle organization)|go:"GO:0019899"(enzyme binding)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030379"(neurotensin receptor activity, non-G protein-coupled)|go:"GO:0030425"(dendrite)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032509"(endosome transport via multivesicular body sorting pathway)|go:"GO:0032580"(Golgi cisterna membrane)|go:"GO:0032868"(response to insulin)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0046323"(glucose import)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048227"(plasma membrane to endosome transport)|go:"GO:0048406"(nerve growth factor binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051005"(negative regulation of lipoprotein lipase activity)|go:"GO:0090160"(Golgi to lysosome transport)|go:"GO:1904037"(positive regulation of epithelial cell apoptotic process)|go:"GO:1905394"(retromer complex binding)|interpro:IPR006581(VPS10)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR031777|interpro:IPR031778|mint:Q6PHU5|rcsb pdb:5NMR|rcsb pdb:5NMT|rcsb pdb:5NNI|rcsb pdb:5NNJ|refseq:NP_064356.2|refseq:NP_001258528.1|dip:DIP-46095N ensembl:ENSMUSG00000031988(gene)|ensembl:ENSMUST00000034470(transcript)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005829"(cytosol)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0030904"(retromer complex)|go:"GO:0042147"(retrograde transport, endosome to Golgi)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0071346"(cellular response to interferon-gamma)|interpro:IPR014752(Arrestin, C-terminal)|interpro:IPR028934|mint:Q8C0E2|rcsb pdb:2R51|rcsb pdb:3LH8|rcsb pdb:3LH9|rcsb pdb:3LHA|refseq:NP_821170.1 - function:"Functions as a sorting receptor in the Golgi compartment and as a clearance receptor on the cell surface. Required for protein transport from the Golgi apparatus to the lysosomes by a pathway that is independent of the mannose-6-phosphate receptor (M6PR). Also required for protein transport from the Golgi apparatus to the endosomes. Promotes neuronal apoptosis by mediating endocytosis of the proapoptotic precursor forms of BDNF (proBDNF) and NGFB (proNGFB). Also acts as a receptor for neurotensin. May promote mineralization of the extracellular matrix during osteogenic differentiation by scavenging extracellular LPL. Probably required in adipocytes for the formation of specialized storage vesicles containing the glucose transporter SLC2A4/GLUT4 (GLUT4 storage vesicles, or GSVs). These vesicles provide a stable pool of SLC2A4 and confer increased responsiveness to insulin. May also mediate transport from the endoplasmic reticulum to the Golgi"|comment:mint comment:mint|function:"Probable component of the retromer complex, a complex required to retrieve lysosomal enzyme receptors (IGF2R and M6PR) from endosomes to the trans-Golgi network" figure legend:4C|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain) - 2014/10/02 2019/07/08 rogid:YWk1GufR/sfGvpibzo3UOxenP7s10090 rogid:0ldtjq7g6fEiaFTAusA8J+Xy4Qg10090 intact-crc:B30875F0EE4CF51C|rigid:ZzCswVhiL4AvilxrHxExAkfWc84 false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q6PHU5 uniprotkb:P01139 intact:EBI-6985663|ensembl:ENSMUSP00000099692|uniprotkb:Q9QXW6|uniprotkb:A2AEE8|uniprotkb:Q8K043|uniprotkb:Q3UHE2|intact:MINT-4130555 intact:EBI-9826976|uniprotkb:Q63864|uniprotkb:Q6LDB7|ensembl:ENSMUSP00000040345 psi-mi:sort_mouse(display_long)|uniprotkb:Sort1(gene name)|psi-mi:Sort1(display_short)|uniprotkb:Neurotensin receptor 3(gene name synonym) psi-mi:ngf_mouse(display_long)|uniprotkb:Ngf(gene name)|psi-mi:Ngf(display_short)|uniprotkb:Ngfb(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Kim et al. (2010) pubmed:21040701|imex:IM-23234 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-9827151|imex:IM-23234-6 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000068747(gene)|ensembl:ENSMUST00000102632(transcript)|go:"GO:0001503"(ossification)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005769"(early endosome)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006622"(protein targeting to lysosome)|rcsb pdb:5ZNN|reactome:R-MMU-432722|go:"GO:0006892"(post-Golgi vesicle-mediated transport)|go:"GO:0006895"(Golgi to endosome transport)|go:"GO:0006897"(endocytosis)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007218"(neuropeptide signaling pathway)|go:"GO:0008333"(endosome to lysosome transport)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0009986"(cell surface)|go:"GO:0010008"(endosome membrane)|go:"GO:0010465"(nerve growth factor receptor activity)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0014902"(myotube differentiation)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016050"(vesicle organization)|go:"GO:0019899"(enzyme binding)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030379"(neurotensin receptor activity, non-G protein-coupled)|go:"GO:0030425"(dendrite)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032509"(endosome transport via multivesicular body sorting pathway)|go:"GO:0032580"(Golgi cisterna membrane)|go:"GO:0032868"(response to insulin)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0046323"(glucose import)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048227"(plasma membrane to endosome transport)|go:"GO:0048406"(nerve growth factor binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051005"(negative regulation of lipoprotein lipase activity)|go:"GO:0090160"(Golgi to lysosome transport)|go:"GO:1904037"(positive regulation of epithelial cell apoptotic process)|go:"GO:1905394"(retromer complex binding)|interpro:IPR006581(VPS10)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR031777|interpro:IPR031778|mint:Q6PHU5|rcsb pdb:5NMR|rcsb pdb:5NMT|rcsb pdb:5NNI|rcsb pdb:5NNJ|refseq:NP_064356.2|refseq:NP_001258528.1|dip:DIP-46095N refseq:NP_001106168.1|refseq:NP_038637.1|refseq:XP_006501171.1|dip:DIP-59840N|ensembl:ENSMUSG00000027859(gene)|ensembl:ENSMUST00000035952(transcript)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0005163"(nerve growth factor receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007422"(peripheral nervous system development)|go:"GO:0007613"(memory)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008083"(growth factor activity)|go:"GO:0008191"(metalloendopeptidase inhibitor activity)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008289"(lipid binding)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0008656"(cysteine-type endopeptidase activator activity involved in apoptotic process)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014042"(positive regulation of neuron maturation)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0021675"(nerve development)|go:"GO:0030297"(transmembrane receptor protein tyrosine kinase activator activity)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031175"(neuron projection development)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031904"(endosome lumen)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0038177"(death receptor agonist activity)|go:"GO:0038180"(nerve growth factor signaling pathway)|go:"GO:0043388"(positive regulation of DNA binding)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0045664"(regulation of neuron differentiation)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045773"(positive regulation of axon extension)|go:"GO:0046579"(positive regulation of Ras protein signal transduction)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0048666"(neuron development)|go:"GO:0048672"(positive regulation of collateral sprouting)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051279"(regulation of release of sequestered calcium ion into cytosol)|go:"GO:0051388"(positive regulation of neurotrophin TRK receptor signaling pathway)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:2000648"(positive regulation of stem cell proliferation)|go:"GO:2000675"(negative regulation of type B pancreatic cell apoptotic process)|interpro:IPR002072(Nerve growth factor)|interpro:IPR019846|interpro:IPR020408|interpro:IPR020425|interpro:IPR020437|interpro:IPR029034|rcsb pdb:1BET|rcsb pdb:1BTG|rcsb pdb:1SGF|rcsb pdb:3IJ2|rcsb pdb:4EAX|rcsb pdb:4XPJ|rcsb pdb:5LSD|rcsb pdb:6FFY|reactome:R-MMU-167060|reactome:R-MMU-170968|reactome:R-MMU-170984|reactome:R-MMU-177504|reactome:R-MMU-187042|reactome:R-MMU-198203|reactome:R-MMU-205017|reactome:R-MMU-205025|reactome:R-MMU-205043|reactome:R-MMU-209543|reactome:R-MMU-209560|reactome:R-MMU-209563|go:"GO:0031954"(positive regulation of protein autophosphorylation) - function:"Functions as a sorting receptor in the Golgi compartment and as a clearance receptor on the cell surface. Required for protein transport from the Golgi apparatus to the lysosomes by a pathway that is independent of the mannose-6-phosphate receptor (M6PR). Also required for protein transport from the Golgi apparatus to the endosomes. Promotes neuronal apoptosis by mediating endocytosis of the proapoptotic precursor forms of BDNF (proBDNF) and NGFB (proNGFB). Also acts as a receptor for neurotensin. May promote mineralization of the extracellular matrix during osteogenic differentiation by scavenging extracellular LPL. Probably required in adipocytes for the formation of specialized storage vesicles containing the glucose transporter SLC2A4/GLUT4 (GLUT4 storage vesicles, or GSVs). These vesicles provide a stable pool of SLC2A4 and confer increased responsiveness to insulin. May also mediate transport from the endoplasmic reticulum to the Golgi"|comment:mint - figure legend:4C|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain) - 2014/10/02 2019/07/08 rogid:YWk1GufR/sfGvpibzo3UOxenP7s10090 rogid:0iMgi2FIeSIisDsL1KEKr37dtWE10090 intact-crc:B30875F0EE4CF51C|rigid:ZzCswVhiL4AvilxrHxExAkfWc84 false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q6PHU5 uniprotkb:Q9Z0W1 intact:EBI-6985663|ensembl:ENSMUSP00000099692|uniprotkb:Q9QXW6|uniprotkb:A2AEE8|uniprotkb:Q8K043|uniprotkb:Q3UHE2|intact:MINT-4130555 intact:EBI-4411273|uniprotkb:Q8CFT3|ensembl:ENSMUSP00000000122 psi-mi:sort_mouse(display_long)|uniprotkb:Sort1(gene name)|psi-mi:Sort1(display_short)|uniprotkb:Neurotensin receptor 3(gene name synonym) psi-mi:tnr16_mouse(display_long)|uniprotkb:Ngfr(gene name)|psi-mi:Ngfr(display_short)|uniprotkb:Tnfrsf16(gene name synonym)|uniprotkb:Low affinity neurotrophin receptor p75NTR(gene name synonym)|uniprotkb:Low-affinity nerve growth factor receptor(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Kim et al. (2010) pubmed:21040701|imex:IM-23234 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-9827151|imex:IM-23234-6 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000068747(gene)|ensembl:ENSMUST00000102632(transcript)|go:"GO:0001503"(ossification)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005769"(early endosome)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006622"(protein targeting to lysosome)|rcsb pdb:5ZNN|reactome:R-MMU-432722|go:"GO:0006892"(post-Golgi vesicle-mediated transport)|go:"GO:0006895"(Golgi to endosome transport)|go:"GO:0006897"(endocytosis)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007218"(neuropeptide signaling pathway)|go:"GO:0008333"(endosome to lysosome transport)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0009986"(cell surface)|go:"GO:0010008"(endosome membrane)|go:"GO:0010465"(nerve growth factor receptor activity)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0014902"(myotube differentiation)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016050"(vesicle organization)|go:"GO:0019899"(enzyme binding)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030379"(neurotensin receptor activity, non-G protein-coupled)|go:"GO:0030425"(dendrite)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032509"(endosome transport via multivesicular body sorting pathway)|go:"GO:0032580"(Golgi cisterna membrane)|go:"GO:0032868"(response to insulin)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0046323"(glucose import)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048227"(plasma membrane to endosome transport)|go:"GO:0048406"(nerve growth factor binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051005"(negative regulation of lipoprotein lipase activity)|go:"GO:0090160"(Golgi to lysosome transport)|go:"GO:1904037"(positive regulation of epithelial cell apoptotic process)|go:"GO:1905394"(retromer complex binding)|interpro:IPR006581(VPS10)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR031777|interpro:IPR031778|mint:Q6PHU5|rcsb pdb:5NMR|rcsb pdb:5NMT|rcsb pdb:5NNI|rcsb pdb:5NNJ|refseq:NP_064356.2|refseq:NP_001258528.1|dip:DIP-46095N refseq:NP_150086.2|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031643"(positive regulation of myelination)|go:"GO:0032224"(positive regulation of synaptic transmission, cholinergic)|go:"GO:0032590"(dendrite membrane)|go:"GO:0032809"(neuronal cell body membrane)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0035025"(positive regulation of Rho protein signal transduction)|go:"GO:0035907"(dorsal aorta development)|go:"GO:0040037"(negative regulation of fibroblast growth factor receptor signaling pathway)|go:"GO:0042488"(positive regulation of odontogenesis of dentin-containing tooth)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043121"(neurotrophin binding)|go:"GO:0043197"(dendritic spine)|go:"GO:0043204"(perikaryon)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043588"(skin development)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045334"(clathrin-coated endocytic vesicle)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0048406"(nerve growth factor binding)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0051799"(negative regulation of hair follicle development)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051902"(negative regulation of mitochondrial depolarization)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0061000"(negative regulation of dendritic spine development)|go:"GO:0070678"(preprotein binding)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:0031267"(small GTPase binding)|ensembl:ENSMUSG00000000120(gene)|ensembl:ENSMUST00000000122(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001678"(cellular glucose homeostasis)|go:"GO:0005035"(death receptor activity)|go:"GO:0005168"(neurotrophin TRKA receptor binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2001235"(positive regulation of apoptotic signaling pathway)|interpro:IPR000488(Death)|interpro:IPR001368(TNFR/CD27/30/40/95 cysteine-rich region)|interpro:IPR011029(DEATH-like)|interpro:IPR022325|interpro:IPR034046|interpro:IPR041448|mint:Q9Z0W1|reactome:R-MMU-193634|reactome:R-MMU-193692|reactome:R-MMU-205017|reactome:R-MMU-205025|reactome:R-MMU-205043|reactome:R-MMU-209543|reactome:R-MMU-209560|reactome:R-MMU-209563|go:"GO:1903588"(negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0007411"(axon guidance)|go:"GO:0007417"(central nervous system development)|go:"GO:0007623"(circadian rhythm)|go:"GO:0009611"(response to wounding)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010941"(regulation of cell death)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015026"(coreceptor activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016048"(detection of temperature stimulus)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0021675"(nerve development)|go:"GO:0030135"(coated vesicle)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030426"(growth cone)|go:"GO:0031069"(hair follicle morphogenesis)|go:"GO:0005739"(mitochondrion) - function:"Functions as a sorting receptor in the Golgi compartment and as a clearance receptor on the cell surface. Required for protein transport from the Golgi apparatus to the lysosomes by a pathway that is independent of the mannose-6-phosphate receptor (M6PR). Also required for protein transport from the Golgi apparatus to the endosomes. Promotes neuronal apoptosis by mediating endocytosis of the proapoptotic precursor forms of BDNF (proBDNF) and NGFB (proNGFB). Also acts as a receptor for neurotensin. May promote mineralization of the extracellular matrix during osteogenic differentiation by scavenging extracellular LPL. Probably required in adipocytes for the formation of specialized storage vesicles containing the glucose transporter SLC2A4/GLUT4 (GLUT4 storage vesicles, or GSVs). These vesicles provide a stable pool of SLC2A4 and confer increased responsiveness to insulin. May also mediate transport from the endoplasmic reticulum to the Golgi"|comment:mint - figure legend:4C|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain) - 2014/10/02 2019/07/08 rogid:YWk1GufR/sfGvpibzo3UOxenP7s10090 rogid:fGGb/QZNuWJkmI1WqYyELFX3Vgs10090 intact-crc:B30875F0EE4CF51C|rigid:ZzCswVhiL4AvilxrHxExAkfWc84 false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q6PHU5 uniprotkb:Q9EQH3 intact:EBI-6985663|ensembl:ENSMUSP00000099692|uniprotkb:Q9QXW6|uniprotkb:A2AEE8|uniprotkb:Q8K043|uniprotkb:Q3UHE2|intact:MINT-4130555 intact:EBI-775825|uniprotkb:Q61123|ensembl:ENSMUSP00000034131 psi-mi:sort_mouse(display_long)|uniprotkb:Sort1(gene name)|psi-mi:Sort1(display_short)|uniprotkb:Neurotensin receptor 3(gene name synonym) psi-mi:vps35_mouse(display_long)|uniprotkb:Vesicle protein sorting 35(gene name synonym)|uniprotkb:Maternal-embryonic 3(gene name synonym)|uniprotkb:Vps35(gene name)|psi-mi:Vps35(display_short)|uniprotkb:Mem3(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Kim et al. (2010) pubmed:21040701|imex:IM-23234 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-9827151|imex:IM-23234-6 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000068747(gene)|ensembl:ENSMUST00000102632(transcript)|go:"GO:0001503"(ossification)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005769"(early endosome)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006622"(protein targeting to lysosome)|rcsb pdb:5ZNN|reactome:R-MMU-432722|go:"GO:0006892"(post-Golgi vesicle-mediated transport)|go:"GO:0006895"(Golgi to endosome transport)|go:"GO:0006897"(endocytosis)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007218"(neuropeptide signaling pathway)|go:"GO:0008333"(endosome to lysosome transport)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0009986"(cell surface)|go:"GO:0010008"(endosome membrane)|go:"GO:0010465"(nerve growth factor receptor activity)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0014902"(myotube differentiation)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016050"(vesicle organization)|go:"GO:0019899"(enzyme binding)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030379"(neurotensin receptor activity, non-G protein-coupled)|go:"GO:0030425"(dendrite)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032509"(endosome transport via multivesicular body sorting pathway)|go:"GO:0032580"(Golgi cisterna membrane)|go:"GO:0032868"(response to insulin)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0046323"(glucose import)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048227"(plasma membrane to endosome transport)|go:"GO:0048406"(nerve growth factor binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051005"(negative regulation of lipoprotein lipase activity)|go:"GO:0090160"(Golgi to lysosome transport)|go:"GO:1904037"(positive regulation of epithelial cell apoptotic process)|go:"GO:1905394"(retromer complex binding)|interpro:IPR006581(VPS10)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR031777|interpro:IPR031778|mint:Q6PHU5|rcsb pdb:5NMR|rcsb pdb:5NMT|rcsb pdb:5NNI|rcsb pdb:5NNJ|refseq:NP_064356.2|refseq:NP_001258528.1|dip:DIP-46095N refseq:NP_075373.1|dip:DIP-32210N|ensembl:ENSMUSG00000031696(gene)|ensembl:ENSMUST00000034131(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005829"(cytosol)|go:"GO:0006624"(vacuolar protein processing)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0007040"(lysosome organization)|go:"GO:0007416"(synapse assembly)|go:"GO:0010008"(endosome membrane)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010821"(regulation of mitochondrion organization)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030904"(retromer complex)|go:"GO:0030906"(retromer, cargo-selective complex)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031648"(protein destabilization)|go:"GO:0031748"(D1 dopamine receptor binding)|go:"GO:0032268"(regulation of cellular protein metabolic process)|go:"GO:0032456"(endocytic recycling)|go:"GO:0032463"(negative regulation of protein homooligomerization)|go:"GO:0033365"(protein localization to organelle)|go:"GO:0036010"(protein localization to endosome)|go:"GO:0042147"(retrograde transport, endosome to Golgi)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043653"(mitochondrial fragmentation involved in apoptotic process)|go:"GO:0045056"(transcytosis)|go:"GO:0045202"(synapse)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0050882"(voluntary musculoskeletal movement)|go:"GO:0060161"(positive regulation of dopamine receptor signaling pathway)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0061357"(positive regulation of Wnt protein secretion)|go:"GO:0090141"(positive regulation of mitochondrial fission)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0090326"(positive regulation of locomotion involved in locomotory behavior)|go:"GO:0097422"(tubular endosome)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098887"(neurotransmitter receptor transport, endosome to postsynaptic membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099003"(vesicle-mediated transport in synapse)|go:"GO:0099073"(mitochondrion-derived vesicle)|go:"GO:0099074"(mitochondrion to lysosome transport)|go:"GO:0099639"(neurotransmitter receptor transport, endosome to plasma membrane)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902823"(negative regulation of late endosome to lysosome transport)|go:"GO:1902950"(regulation of dendritic spine maintenance)|go:"GO:1903181"(positive regulation of dopamine biosynthetic process)|go:"GO:1903364"(positive regulation of cellular protein catabolic process)|go:"GO:1903828"(negative regulation of protein localization)|go:"GO:1905166"(negative regulation of lysosomal protein catabolic process)|go:"GO:2000331"(regulation of terminal button organization)|interpro:IPR005378(Vacuolar protein sorting-associated protein 35)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR042491|mint:Q9EQH3|rcsb pdb:6VAB|rcsb pdb:6VAC|reactome:R-MMU-3238698 - function:"Functions as a sorting receptor in the Golgi compartment and as a clearance receptor on the cell surface. Required for protein transport from the Golgi apparatus to the lysosomes by a pathway that is independent of the mannose-6-phosphate receptor (M6PR). Also required for protein transport from the Golgi apparatus to the endosomes. Promotes neuronal apoptosis by mediating endocytosis of the proapoptotic precursor forms of BDNF (proBDNF) and NGFB (proNGFB). Also acts as a receptor for neurotensin. May promote mineralization of the extracellular matrix during osteogenic differentiation by scavenging extracellular LPL. Probably required in adipocytes for the formation of specialized storage vesicles containing the glucose transporter SLC2A4/GLUT4 (GLUT4 storage vesicles, or GSVs). These vesicles provide a stable pool of SLC2A4 and confer increased responsiveness to insulin. May also mediate transport from the endoplasmic reticulum to the Golgi"|comment:mint - figure legend:4C|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain) - 2014/10/02 2019/07/08 rogid:YWk1GufR/sfGvpibzo3UOxenP7s10090 rogid:dK5TqSajxrGKjiNwRjeZCV519XE10090 intact-crc:B30875F0EE4CF51C|rigid:ZzCswVhiL4AvilxrHxExAkfWc84 false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q8C0E2 uniprotkb:Q9QZ88 intact:EBI-8314940|ensembl:ENSMUSP00000034470|uniprotkb:Q8K2V3|uniprotkb:Q3TN45|intact:MINT-3253852 intact:EBI-8334188|intact:MINT-4140090|uniprotkb:Q9D107|uniprotkb:Q3UCZ0|ensembl:ENSMUSP00000121020 psi-mi:vp26b_mouse(display_long)|uniprotkb:Vps26b(gene name)|psi-mi:Vps26b(display_short)|uniprotkb:Vesicle protein sorting 26B(gene name synonym) psi-mi:vps29_mouse(display_long)|uniprotkb:Vps29(gene name)|psi-mi:Vps29(display_short)|uniprotkb:Vesicle protein sorting 29(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Kim et al. (2010) pubmed:21040701|imex:IM-23234 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-9827144|imex:IM-23234-5 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000031988(gene)|ensembl:ENSMUST00000034470(transcript)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005829"(cytosol)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0030904"(retromer complex)|go:"GO:0042147"(retrograde transport, endosome to Golgi)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0071346"(cellular response to interferon-gamma)|interpro:IPR014752(Arrestin, C-terminal)|interpro:IPR028934|mint:Q8C0E2|rcsb pdb:2R51|rcsb pdb:3LH8|rcsb pdb:3LH9|rcsb pdb:3LHA|refseq:NP_821170.1 refseq:NP_062754.1|refseq:NP_001334382.1|dip:DIP-60495N|ensembl:ENSMUSG00000029462(gene)|ensembl:ENSMUST00000155671(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006896"(Golgi to vacuole transport)|go:"GO:0010008"(endosome membrane)|go:"GO:0030904"(retromer complex)|go:"GO:0030906"(retromer, cargo-selective complex)|go:"GO:0032456"(endocytic recycling)|go:"GO:0042147"(retrograde transport, endosome to Golgi)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0046872"(metal ion binding)|interpro:IPR000979(Protein of unknown function UPF0025)|interpro:IPR024654|interpro:IPR028661|interpro:IPR029052|mint:Q9QZ88|rcsb pdb:1Z2W|rcsb pdb:1Z2X|rcsb pdb:3PSN|rcsb pdb:3PSO|rcsb pdb:6TL0|rcsb pdb:6VAB|rcsb pdb:6VAC|reactome:R-MMU-3238698|go:"GO:0005768"(endosome) - comment:mint|function:"Probable component of the retromer complex, a complex required to retrieve lysosomal enzyme receptors (IGF2R and M6PR) from endosomes to the trans-Golgi network" function:"Essential component of the retromer complex, a complex required to retrieve lysosomal enzyme receptors (IGF2R and M6PR) from endosomes to the trans-Golgi network. Also required to regulate transcytosis of the polymeric immunoglobulin receptor (pIgR-pIgA). Has low protein phosphatase activity towards a serine-phosphorylated peptide derived from IGF2R (in vitro) (By similarity). Has no activity towards p-nitrophenylphosphate, p-nitrophenylphosphorylcholine or phosphatidylinositlphosphates (in vitro)"|comment:mint figure legend:3B|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain) - 2014/10/02 2014/10/16 rogid:0ldtjq7g6fEiaFTAusA8J+Xy4Qg10090 rogid:XLAmkQXgIRvAF4JDcavWOR9CnsY10090 intact-crc:55EF9E3089591688|rigid:BdSqHzHqKodB/ABIIJ4qGezudlQ false flag tag:?-? - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q8C0E2 uniprotkb:Q9EQH3 intact:EBI-8314940|ensembl:ENSMUSP00000034470|uniprotkb:Q8K2V3|uniprotkb:Q3TN45|intact:MINT-3253852 intact:EBI-775825|uniprotkb:Q61123|ensembl:ENSMUSP00000034131 psi-mi:vp26b_mouse(display_long)|uniprotkb:Vps26b(gene name)|psi-mi:Vps26b(display_short)|uniprotkb:Vesicle protein sorting 26B(gene name synonym) psi-mi:vps35_mouse(display_long)|uniprotkb:Vesicle protein sorting 35(gene name synonym)|uniprotkb:Maternal-embryonic 3(gene name synonym)|uniprotkb:Vps35(gene name)|psi-mi:Vps35(display_short)|uniprotkb:Mem3(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Kim et al. (2010) pubmed:21040701|imex:IM-23234 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0914"(association) psi-mi:"MI:0486"(UniProt) intact:EBI-9827144|imex:IM-23234-5 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSMUSG00000031988(gene)|ensembl:ENSMUST00000034470(transcript)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005829"(cytosol)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0030904"(retromer complex)|go:"GO:0042147"(retrograde transport, endosome to Golgi)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0071346"(cellular response to interferon-gamma)|interpro:IPR014752(Arrestin, C-terminal)|interpro:IPR028934|mint:Q8C0E2|rcsb pdb:2R51|rcsb pdb:3LH8|rcsb pdb:3LH9|rcsb pdb:3LHA|refseq:NP_821170.1 refseq:NP_075373.1|dip:DIP-32210N|ensembl:ENSMUSG00000031696(gene)|ensembl:ENSMUST00000034131(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005829"(cytosol)|go:"GO:0006624"(vacuolar protein processing)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0007040"(lysosome organization)|go:"GO:0007416"(synapse assembly)|go:"GO:0010008"(endosome membrane)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010821"(regulation of mitochondrion organization)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030904"(retromer complex)|go:"GO:0030906"(retromer, cargo-selective complex)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031648"(protein destabilization)|go:"GO:0031748"(D1 dopamine receptor binding)|go:"GO:0032268"(regulation of cellular protein metabolic process)|go:"GO:0032456"(endocytic recycling)|go:"GO:0032463"(negative regulation of protein homooligomerization)|go:"GO:0033365"(protein localization to organelle)|go:"GO:0036010"(protein localization to endosome)|go:"GO:0042147"(retrograde transport, endosome to Golgi)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043653"(mitochondrial fragmentation involved in apoptotic process)|go:"GO:0045056"(transcytosis)|go:"GO:0045202"(synapse)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0050882"(voluntary musculoskeletal movement)|go:"GO:0060161"(positive regulation of dopamine receptor signaling pathway)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0061357"(positive regulation of Wnt protein secretion)|go:"GO:0090141"(positive regulation of mitochondrial fission)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0090326"(positive regulation of locomotion involved in locomotory behavior)|go:"GO:0097422"(tubular endosome)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098887"(neurotransmitter receptor transport, endosome to postsynaptic membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099003"(vesicle-mediated transport in synapse)|go:"GO:0099073"(mitochondrion-derived vesicle)|go:"GO:0099074"(mitochondrion to lysosome transport)|go:"GO:0099639"(neurotransmitter receptor transport, endosome to plasma membrane)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902823"(negative regulation of late endosome to lysosome transport)|go:"GO:1902950"(regulation of dendritic spine maintenance)|go:"GO:1903181"(positive regulation of dopamine biosynthetic process)|go:"GO:1903364"(positive regulation of cellular protein catabolic process)|go:"GO:1903828"(negative regulation of protein localization)|go:"GO:1905166"(negative regulation of lysosomal protein catabolic process)|go:"GO:2000331"(regulation of terminal button organization)|interpro:IPR005378(Vacuolar protein sorting-associated protein 35)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR042491|mint:Q9EQH3|rcsb pdb:6VAB|rcsb pdb:6VAC|reactome:R-MMU-3238698 - comment:mint|function:"Probable component of the retromer complex, a complex required to retrieve lysosomal enzyme receptors (IGF2R and M6PR) from endosomes to the trans-Golgi network" - figure legend:3B|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10090(mouse-brain)|taxid:10090(Mus musculus brain) - 2014/10/02 2014/10/16 rogid:0ldtjq7g6fEiaFTAusA8J+Xy4Qg10090 rogid:dK5TqSajxrGKjiNwRjeZCV519XE10090 intact-crc:55EF9E3089591688|rigid:BdSqHzHqKodB/ABIIJ4qGezudlQ false flag tag:?-? - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot)