#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P35968	uniprotkb:P35968	intact:EBI-1005487|intact:EBI-28976571|ensembl:ENSP00000263923|uniprotkb:O60723|uniprotkb:Q14178|uniprotkb:A2RRS0|uniprotkb:B5A925|uniprotkb:C5IFA0	intact:EBI-1005487|intact:EBI-28976571|ensembl:ENSP00000263923|uniprotkb:O60723|uniprotkb:Q14178|uniprotkb:A2RRS0|uniprotkb:B5A925|uniprotkb:C5IFA0	psi-mi:vgfr2_human(display_long)|uniprotkb:Kinase insert domain receptor(gene name synonym)|uniprotkb:Protein-tyrosine kinase receptor flk-1(gene name synonym)|uniprotkb:KDR(gene name)|psi-mi:KDR(display_short)|uniprotkb:FLK1(gene name synonym)|uniprotkb:Fetal liver kinase 1(gene name synonym)|uniprotkb:VEGFR2(gene name synonym)	psi-mi:vgfr2_human(display_long)|uniprotkb:Kinase insert domain receptor(gene name synonym)|uniprotkb:Protein-tyrosine kinase receptor flk-1(gene name synonym)|uniprotkb:KDR(gene name)|psi-mi:KDR(display_short)|uniprotkb:FLK1(gene name synonym)|uniprotkb:Fetal liver kinase 1(gene name synonym)|uniprotkb:VEGFR2(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Mitola et al. (2010)	pubmed:20660291|imex:IM-22165	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-9082749|imex:IM-22165-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0941"(competitor)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002244.1|ensembl:ENSP00000263923|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0016477"(cell migration)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019838"(growth factor binding)|go:"GO:0030054"(cell junction)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0035162"(embryonic hemopoiesis)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|go:"GO:0036324"(vascular endothelial growth factor receptor-2 signaling pathway)|go:"GO:0038033"(positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway)|go:"GO:0038083"(peptidyl-tyrosine autophosphorylation)|go:"GO:0038084"(vascular endothelial growth factor signaling pathway)|go:"GO:0038085"(vascular endothelial growth factor binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043235"(receptor complex)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0045121"(membrane raft)|go:"GO:0045296"(cadherin binding)|go:"GO:0045446"(endothelial cell differentiation)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|go:"GO:0050927"(positive regulation of positive chemotaxis)|go:"GO:0051770"(positive regulation of nitric-oxide synthase biosynthetic process)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0051901"(positive regulation of mitochondrial depolarization)|go:"GO:0061042"(vascular wound healing)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0090141"(positive regulation of mitochondrial fission)|go:"GO:0097443"(sorting endosome)|go:"GO:1904881"(cellular response to hydrogen sulfide)|go:"GO:2000352"(negative regulation of endothelial cell apoptotic process)|go:"GO:2001214"(positive regulation of vasculogenesis)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001824(Receptor tyrosine kinase, class III, conserved site)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR009136(Vascular endothelial growth factor receptor 2, VEGFR2)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR036179|interpro:IPR041348|go:"GO:0090050"(positive regulation of cell migration involved in sprouting angiogenesis)|mint:P35968|rcsb pdb:1VR2|rcsb pdb:1Y6A|rcsb pdb:1Y6B|rcsb pdb:1YWN|rcsb pdb:2M59|rcsb pdb:2MET|rcsb pdb:2MEU|rcsb pdb:2OH4|rcsb pdb:2P2H|rcsb pdb:2P2I|rcsb pdb:2QU5|rcsb pdb:2QU6|rcsb pdb:2RL5|rcsb pdb:2X1W|rcsb pdb:2X1X|rcsb pdb:2XIR|rcsb pdb:3B8Q|rcsb pdb:3B8R|rcsb pdb:3BE2|rcsb pdb:3C7Q|rcsb pdb:3CJF|rcsb pdb:3CJG|rcsb pdb:3CP9|rcsb pdb:3CPB|rcsb pdb:3CPC|rcsb pdb:3DTW|rcsb pdb:3EFL|rcsb pdb:3EWH|rcsb pdb:3KVQ|rcsb pdb:3S35|rcsb pdb:3S36|rcsb pdb:3S37|rcsb pdb:3U6J|rcsb pdb:3V2A|rcsb pdb:3V6B|rcsb pdb:3VHE|rcsb pdb:3VHK|rcsb pdb:3VID|rcsb pdb:3VNT|rcsb pdb:3VO3|rcsb pdb:3WZD|rcsb pdb:3WZE|rcsb pdb:4AG8|rcsb pdb:4AGC|rcsb pdb:4AGD|rcsb pdb:4ASD|rcsb pdb:4ASE|rcsb pdb:5EW3|rcsb pdb:5OYJ|rcsb pdb:6GQO|rcsb pdb:6GQP|rcsb pdb:6GQQ|rcsb pdb:6XVJ|rcsb pdb:6XVK|reactome:R-HSA-194306|reactome:R-HSA-195399|reactome:R-HSA-216083|reactome:R-HSA-4420097|reactome:R-HSA-5218921|reactome:R-HSA-9673768|ensembl:ENSG00000128052(gene)|ensembl:ENST00000263923(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001569"(branching involved in blood vessel morphogenesis)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0002042"(cell migration involved in sprouting angiogenesis)|go:"GO:0002244"(hematopoietic progenitor cell differentiation)|go:"GO:0003158"(endothelium development)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005021"(vascular endothelial growth factor-activated receptor activity)|go:"GO:0005178"(integrin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|dip:DIP-486N	refseq:NP_002244.1|ensembl:ENSP00000263923|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0016477"(cell migration)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019838"(growth factor binding)|go:"GO:0030054"(cell junction)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0035162"(embryonic hemopoiesis)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|go:"GO:0036324"(vascular endothelial growth factor receptor-2 signaling pathway)|go:"GO:0038033"(positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway)|go:"GO:0038083"(peptidyl-tyrosine autophosphorylation)|go:"GO:0038084"(vascular endothelial growth factor signaling pathway)|go:"GO:0038085"(vascular endothelial growth factor binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043235"(receptor complex)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0045121"(membrane raft)|go:"GO:0045296"(cadherin binding)|go:"GO:0045446"(endothelial cell differentiation)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|go:"GO:0050927"(positive regulation of positive chemotaxis)|go:"GO:0051770"(positive regulation of nitric-oxide synthase biosynthetic process)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0051901"(positive regulation of mitochondrial depolarization)|go:"GO:0061042"(vascular wound healing)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0090141"(positive regulation of mitochondrial fission)|go:"GO:0097443"(sorting endosome)|go:"GO:1904881"(cellular response to hydrogen sulfide)|go:"GO:2000352"(negative regulation of endothelial cell apoptotic process)|go:"GO:2001214"(positive regulation of vasculogenesis)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001824(Receptor tyrosine kinase, class III, conserved site)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR009136(Vascular endothelial growth factor receptor 2, VEGFR2)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR036179|interpro:IPR041348|go:"GO:0090050"(positive regulation of cell migration involved in sprouting angiogenesis)|mint:P35968|rcsb pdb:1VR2|rcsb pdb:1Y6A|rcsb pdb:1Y6B|rcsb pdb:1YWN|rcsb pdb:2M59|rcsb pdb:2MET|rcsb pdb:2MEU|rcsb pdb:2OH4|rcsb pdb:2P2H|rcsb pdb:2P2I|rcsb pdb:2QU5|rcsb pdb:2QU6|rcsb pdb:2RL5|rcsb pdb:2X1W|rcsb pdb:2X1X|rcsb pdb:2XIR|rcsb pdb:3B8Q|rcsb pdb:3B8R|rcsb pdb:3BE2|rcsb pdb:3C7Q|rcsb pdb:3CJF|rcsb pdb:3CJG|rcsb pdb:3CP9|rcsb pdb:3CPB|rcsb pdb:3CPC|rcsb pdb:3DTW|rcsb pdb:3EFL|rcsb pdb:3EWH|rcsb pdb:3KVQ|rcsb pdb:3S35|rcsb pdb:3S36|rcsb pdb:3S37|rcsb pdb:3U6J|rcsb pdb:3V2A|rcsb pdb:3V6B|rcsb pdb:3VHE|rcsb pdb:3VHK|rcsb pdb:3VID|rcsb pdb:3VNT|rcsb pdb:3VO3|rcsb pdb:3WZD|rcsb pdb:3WZE|rcsb pdb:4AG8|rcsb pdb:4AGC|rcsb pdb:4AGD|rcsb pdb:4ASD|rcsb pdb:4ASE|rcsb pdb:5EW3|rcsb pdb:5OYJ|rcsb pdb:6GQO|rcsb pdb:6GQP|rcsb pdb:6GQQ|rcsb pdb:6XVJ|rcsb pdb:6XVK|reactome:R-HSA-194306|reactome:R-HSA-195399|reactome:R-HSA-216083|reactome:R-HSA-4420097|reactome:R-HSA-5218921|reactome:R-HSA-9673768|ensembl:ENSG00000128052(gene)|ensembl:ENST00000263923(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001569"(branching involved in blood vessel morphogenesis)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0002042"(cell migration involved in sprouting angiogenesis)|go:"GO:0002244"(hematopoietic progenitor cell differentiation)|go:"GO:0003158"(endothelium development)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005021"(vascular endothelial growth factor-activated receptor activity)|go:"GO:0005178"(integrin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|dip:DIP-486N	-	-	-	figure legend:Fig.1B|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/01/13	2014/10/16	rogid:NnrnIZM28U6DGKYiDT9+sh/fi8Y9606	rogid:NnrnIZM28U6DGKYiDT9+sh/fi8Y9606	intact-crc:FB345F390BB6F4B9|rigid:EFgx7c0YcWNOqlrSiDvl/DZ77EI	false	sufficient binding region:20-757	sufficient binding region:20-757|fc-igg tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P35968	uniprotkb:O60565	intact:EBI-1005487|intact:EBI-28976571|ensembl:ENSP00000263923|uniprotkb:O60723|uniprotkb:Q14178|uniprotkb:A2RRS0|uniprotkb:B5A925|uniprotkb:C5IFA0	intact:EBI-944395|uniprotkb:Q52LV3|uniprotkb:Q8N914|uniprotkb:Q8N936|ensembl:ENSP00000300177|ensembl:ENSP00000498605|ensembl:ENSP00000498748|ensembl:ENSP00000498763|ensembl:ENSP00000498897	psi-mi:vgfr2_human(display_long)|uniprotkb:Kinase insert domain receptor(gene name synonym)|uniprotkb:Protein-tyrosine kinase receptor flk-1(gene name synonym)|uniprotkb:KDR(gene name)|psi-mi:KDR(display_short)|uniprotkb:FLK1(gene name synonym)|uniprotkb:Fetal liver kinase 1(gene name synonym)|uniprotkb:VEGFR2(gene name synonym)	psi-mi:grem1_human(display_long)|uniprotkb:GREM1(gene name)|psi-mi:GREM1(display_short)|uniprotkb:CKTSF1B1(gene name synonym)|uniprotkb:DAND2(gene name synonym)|uniprotkb:DRM(gene name synonym)|uniprotkb:PIG2(orf name)|uniprotkb:Cysteine knot superfamily 1, BMP antagonist 1(gene name synonym)|uniprotkb:Increased in high glucose protein 2(gene name synonym)|uniprotkb:Down-regulated in Mos-transformed cells protein(gene name synonym)|uniprotkb:DAN domain family member 2(gene name synonym)|uniprotkb:Cell proliferation-inducing gene 2 protein(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Mitola et al. (2010)	pubmed:20660291|imex:IM-22165	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-9082749|imex:IM-22165-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002244.1|ensembl:ENSP00000263923|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0016477"(cell migration)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019838"(growth factor binding)|go:"GO:0030054"(cell junction)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0035162"(embryonic hemopoiesis)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|go:"GO:0036324"(vascular endothelial growth factor receptor-2 signaling pathway)|go:"GO:0038033"(positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway)|go:"GO:0038083"(peptidyl-tyrosine autophosphorylation)|go:"GO:0038084"(vascular endothelial growth factor signaling pathway)|go:"GO:0038085"(vascular endothelial growth factor binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043235"(receptor complex)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0045121"(membrane raft)|go:"GO:0045296"(cadherin binding)|go:"GO:0045446"(endothelial cell differentiation)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|go:"GO:0050927"(positive regulation of positive chemotaxis)|go:"GO:0051770"(positive regulation of nitric-oxide synthase biosynthetic process)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0051901"(positive regulation of mitochondrial depolarization)|go:"GO:0061042"(vascular wound healing)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0090141"(positive regulation of mitochondrial fission)|go:"GO:0097443"(sorting endosome)|go:"GO:1904881"(cellular response to hydrogen sulfide)|go:"GO:2000352"(negative regulation of endothelial cell apoptotic process)|go:"GO:2001214"(positive regulation of vasculogenesis)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001824(Receptor tyrosine kinase, class III, conserved site)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR009136(Vascular endothelial growth factor receptor 2, VEGFR2)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR036179|interpro:IPR041348|go:"GO:0090050"(positive regulation of cell migration involved in sprouting angiogenesis)|mint:P35968|rcsb pdb:1VR2|rcsb pdb:1Y6A|rcsb pdb:1Y6B|rcsb pdb:1YWN|rcsb pdb:2M59|rcsb pdb:2MET|rcsb pdb:2MEU|rcsb pdb:2OH4|rcsb pdb:2P2H|rcsb pdb:2P2I|rcsb pdb:2QU5|rcsb pdb:2QU6|rcsb pdb:2RL5|rcsb pdb:2X1W|rcsb pdb:2X1X|rcsb pdb:2XIR|rcsb pdb:3B8Q|rcsb pdb:3B8R|rcsb pdb:3BE2|rcsb pdb:3C7Q|rcsb pdb:3CJF|rcsb pdb:3CJG|rcsb pdb:3CP9|rcsb pdb:3CPB|rcsb pdb:3CPC|rcsb pdb:3DTW|rcsb pdb:3EFL|rcsb pdb:3EWH|rcsb pdb:3KVQ|rcsb pdb:3S35|rcsb pdb:3S36|rcsb pdb:3S37|rcsb pdb:3U6J|rcsb pdb:3V2A|rcsb pdb:3V6B|rcsb pdb:3VHE|rcsb pdb:3VHK|rcsb pdb:3VID|rcsb pdb:3VNT|rcsb pdb:3VO3|rcsb pdb:3WZD|rcsb pdb:3WZE|rcsb pdb:4AG8|rcsb pdb:4AGC|rcsb pdb:4AGD|rcsb pdb:4ASD|rcsb pdb:4ASE|rcsb pdb:5EW3|rcsb pdb:5OYJ|rcsb pdb:6GQO|rcsb pdb:6GQP|rcsb pdb:6GQQ|rcsb pdb:6XVJ|rcsb pdb:6XVK|reactome:R-HSA-194306|reactome:R-HSA-195399|reactome:R-HSA-216083|reactome:R-HSA-4420097|reactome:R-HSA-5218921|reactome:R-HSA-9673768|ensembl:ENSG00000128052(gene)|ensembl:ENST00000263923(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001569"(branching involved in blood vessel morphogenesis)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0002042"(cell migration involved in sprouting angiogenesis)|go:"GO:0002244"(hematopoietic progenitor cell differentiation)|go:"GO:0003158"(endothelium development)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005021"(vascular endothelial growth factor-activated receptor activity)|go:"GO:0005178"(integrin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|dip:DIP-486N	refseq:NP_001178252.1|refseq:NP_037504.1|go:"GO:0090190"(positive regulation of branching involved in ureteric bud morphogenesis)|go:"GO:0090291"(negative regulation of osteoclast proliferation)|go:"GO:1900086"(positive regulation of peptidyl-tyrosine autophosphorylation)|go:"GO:1900155"(negative regulation of bone trabecula formation)|go:"GO:1900158"(negative regulation of bone mineralization involved in bone maturation)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:2000273"(positive regulation of signaling receptor activity)|go:"GO:2000727"(positive regulation of cardiac muscle cell differentiation)|interpro:IPR004133(DAN)|interpro:IPR006207(Cystine knot, C-terminal)|interpro:IPR017159(Gremlin precursor)|interpro:IPR029034|rcsb pdb:5AEJ|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|ensembl:ENSG00000166923(gene)|ensembl:ENSG00000276886(gene)|ensembl:ENSG00000282046(gene)|ensembl:ENST00000300177(transcript)|ensembl:ENST00000651081(transcript)|ensembl:ENST00000651154(transcript)|ensembl:ENST00000651986(transcript)|ensembl:ENST00000652365(transcript)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0002042"(cell migration involved in sprouting angiogenesis)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0003257"(positive regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation)|go:"GO:0003337"(mesenchymal to epithelial transition involved in metanephros morphogenesis)|go:"GO:0005125"(cytokine activity)|go:"GO:0005615"(extracellular space)|go:"GO:0006915"(apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0009954"(proximal/distal pattern formation)|go:"GO:0009986"(cell surface)|go:"GO:0010717"(regulation of epithelial to mesenchymal transition)|go:"GO:0016015"(morphogen activity)|go:"GO:0030199"(collagen fibril organization)|go:"GO:0030297"(transmembrane receptor protein tyrosine kinase activator activity)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030326"(embryonic limb morphogenesis)|go:"GO:0030502"(negative regulation of bone mineralization)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0032331"(negative regulation of chondrocyte differentiation)|go:"GO:0033689"(negative regulation of osteoblast proliferation)|go:"GO:0036122"(BMP binding)|go:"GO:0038098"(sequestering of BMP from receptor via BMP binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043184"(vascular endothelial growth factor receptor 2 binding)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046851"(negative regulation of bone remodeling)|go:"GO:0048018"(receptor ligand activity)|go:"GO:0048263"(determination of dorsal identity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051893"(regulation of focal adhesion assembly)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0060173"(limb development)|go:"GO:0060394"(negative regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0060676"(ureteric bud formation)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0090027"(negative regulation of monocyte chemotaxis)	-	-	-	figure legend:Fig.1B|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/01/13	2014/10/16	rogid:NnrnIZM28U6DGKYiDT9+sh/fi8Y9606	rogid:eo1SLD8rZOBrQBcawMffMRz4Ex09606	intact-crc:FB345F390BB6F4B9|rigid:EFgx7c0YcWNOqlrSiDvl/DZ77EI	false	sufficient binding region:20-757	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O60565	uniprotkb:P35968	intact:EBI-944395|uniprotkb:Q52LV3|uniprotkb:Q8N914|uniprotkb:Q8N936|ensembl:ENSP00000300177|ensembl:ENSP00000498605|ensembl:ENSP00000498748|ensembl:ENSP00000498763|ensembl:ENSP00000498897	intact:EBI-1005487|intact:EBI-28976571|ensembl:ENSP00000263923|uniprotkb:O60723|uniprotkb:Q14178|uniprotkb:A2RRS0|uniprotkb:B5A925|uniprotkb:C5IFA0	psi-mi:grem1_human(display_long)|uniprotkb:GREM1(gene name)|psi-mi:GREM1(display_short)|uniprotkb:CKTSF1B1(gene name synonym)|uniprotkb:DAND2(gene name synonym)|uniprotkb:DRM(gene name synonym)|uniprotkb:PIG2(orf name)|uniprotkb:Cysteine knot superfamily 1, BMP antagonist 1(gene name synonym)|uniprotkb:Increased in high glucose protein 2(gene name synonym)|uniprotkb:Down-regulated in Mos-transformed cells protein(gene name synonym)|uniprotkb:DAN domain family member 2(gene name synonym)|uniprotkb:Cell proliferation-inducing gene 2 protein(gene name synonym)	psi-mi:vgfr2_human(display_long)|uniprotkb:Kinase insert domain receptor(gene name synonym)|uniprotkb:Protein-tyrosine kinase receptor flk-1(gene name synonym)|uniprotkb:KDR(gene name)|psi-mi:KDR(display_short)|uniprotkb:FLK1(gene name synonym)|uniprotkb:Fetal liver kinase 1(gene name synonym)|uniprotkb:VEGFR2(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Mitola et al. (2010)	pubmed:20660291|imex:IM-22165	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-9096433|imex:IM-22165-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001178252.1|refseq:NP_037504.1|go:"GO:0090190"(positive regulation of branching involved in ureteric bud morphogenesis)|go:"GO:0090291"(negative regulation of osteoclast proliferation)|go:"GO:1900086"(positive regulation of peptidyl-tyrosine autophosphorylation)|go:"GO:1900155"(negative regulation of bone trabecula formation)|go:"GO:1900158"(negative regulation of bone mineralization involved in bone maturation)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:2000273"(positive regulation of signaling receptor activity)|go:"GO:2000727"(positive regulation of cardiac muscle cell differentiation)|interpro:IPR004133(DAN)|interpro:IPR006207(Cystine knot, C-terminal)|interpro:IPR017159(Gremlin precursor)|interpro:IPR029034|rcsb pdb:5AEJ|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|ensembl:ENSG00000166923(gene)|ensembl:ENSG00000276886(gene)|ensembl:ENSG00000282046(gene)|ensembl:ENST00000300177(transcript)|ensembl:ENST00000651081(transcript)|ensembl:ENST00000651154(transcript)|ensembl:ENST00000651986(transcript)|ensembl:ENST00000652365(transcript)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0002042"(cell migration involved in sprouting angiogenesis)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0003257"(positive regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation)|go:"GO:0003337"(mesenchymal to epithelial transition involved in metanephros morphogenesis)|go:"GO:0005125"(cytokine activity)|go:"GO:0005615"(extracellular space)|go:"GO:0006915"(apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0009954"(proximal/distal pattern formation)|go:"GO:0009986"(cell surface)|go:"GO:0010717"(regulation of epithelial to mesenchymal transition)|go:"GO:0016015"(morphogen activity)|go:"GO:0030199"(collagen fibril organization)|go:"GO:0030297"(transmembrane receptor protein tyrosine kinase activator activity)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030326"(embryonic limb morphogenesis)|go:"GO:0030502"(negative regulation of bone mineralization)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0032331"(negative regulation of chondrocyte differentiation)|go:"GO:0033689"(negative regulation of osteoblast proliferation)|go:"GO:0036122"(BMP binding)|go:"GO:0038098"(sequestering of BMP from receptor via BMP binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043184"(vascular endothelial growth factor receptor 2 binding)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046851"(negative regulation of bone remodeling)|go:"GO:0048018"(receptor ligand activity)|go:"GO:0048263"(determination of dorsal identity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051893"(regulation of focal adhesion assembly)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0060173"(limb development)|go:"GO:0060394"(negative regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0060676"(ureteric bud formation)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0090027"(negative regulation of monocyte chemotaxis)	refseq:NP_002244.1|ensembl:ENSP00000263923|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0016477"(cell migration)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019838"(growth factor binding)|go:"GO:0030054"(cell junction)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0035162"(embryonic hemopoiesis)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|go:"GO:0036324"(vascular endothelial growth factor receptor-2 signaling pathway)|go:"GO:0038033"(positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway)|go:"GO:0038083"(peptidyl-tyrosine autophosphorylation)|go:"GO:0038084"(vascular endothelial growth factor signaling pathway)|go:"GO:0038085"(vascular endothelial growth factor binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043235"(receptor complex)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0045121"(membrane raft)|go:"GO:0045296"(cadherin binding)|go:"GO:0045446"(endothelial cell differentiation)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|go:"GO:0050927"(positive regulation of positive chemotaxis)|go:"GO:0051770"(positive regulation of nitric-oxide synthase biosynthetic process)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0051901"(positive regulation of mitochondrial depolarization)|go:"GO:0061042"(vascular wound healing)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0090141"(positive regulation of mitochondrial fission)|go:"GO:0097443"(sorting endosome)|go:"GO:1904881"(cellular response to hydrogen sulfide)|go:"GO:2000352"(negative regulation of endothelial cell apoptotic process)|go:"GO:2001214"(positive regulation of vasculogenesis)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001824(Receptor tyrosine kinase, class III, conserved site)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR009136(Vascular endothelial growth factor receptor 2, VEGFR2)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR036179|interpro:IPR041348|go:"GO:0090050"(positive regulation of cell migration involved in sprouting angiogenesis)|mint:P35968|rcsb pdb:1VR2|rcsb pdb:1Y6A|rcsb pdb:1Y6B|rcsb pdb:1YWN|rcsb pdb:2M59|rcsb pdb:2MET|rcsb pdb:2MEU|rcsb pdb:2OH4|rcsb pdb:2P2H|rcsb pdb:2P2I|rcsb pdb:2QU5|rcsb pdb:2QU6|rcsb pdb:2RL5|rcsb pdb:2X1W|rcsb pdb:2X1X|rcsb pdb:2XIR|rcsb pdb:3B8Q|rcsb pdb:3B8R|rcsb pdb:3BE2|rcsb pdb:3C7Q|rcsb pdb:3CJF|rcsb pdb:3CJG|rcsb pdb:3CP9|rcsb pdb:3CPB|rcsb pdb:3CPC|rcsb pdb:3DTW|rcsb pdb:3EFL|rcsb pdb:3EWH|rcsb pdb:3KVQ|rcsb pdb:3S35|rcsb pdb:3S36|rcsb pdb:3S37|rcsb pdb:3U6J|rcsb pdb:3V2A|rcsb pdb:3V6B|rcsb pdb:3VHE|rcsb pdb:3VHK|rcsb pdb:3VID|rcsb pdb:3VNT|rcsb pdb:3VO3|rcsb pdb:3WZD|rcsb pdb:3WZE|rcsb pdb:4AG8|rcsb pdb:4AGC|rcsb pdb:4AGD|rcsb pdb:4ASD|rcsb pdb:4ASE|rcsb pdb:5EW3|rcsb pdb:5OYJ|rcsb pdb:6GQO|rcsb pdb:6GQP|rcsb pdb:6GQQ|rcsb pdb:6XVJ|rcsb pdb:6XVK|reactome:R-HSA-194306|reactome:R-HSA-195399|reactome:R-HSA-216083|reactome:R-HSA-4420097|reactome:R-HSA-5218921|reactome:R-HSA-9673768|ensembl:ENSG00000128052(gene)|ensembl:ENST00000263923(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001569"(branching involved in blood vessel morphogenesis)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0002042"(cell migration involved in sprouting angiogenesis)|go:"GO:0002244"(hematopoietic progenitor cell differentiation)|go:"GO:0003158"(endothelium development)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005021"(vascular endothelial growth factor-activated receptor activity)|go:"GO:0005178"(integrin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|dip:DIP-486N	-	-	-	figure legend:Fig.1A|causality statement:O60565 increases activity of P35968|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:47.0x10^-9 ~15.0(molar)	2014/01/13	2014/10/16	rogid:eo1SLD8rZOBrQBcawMffMRz4Ex09606	rogid:NnrnIZM28U6DGKYiDT9+sh/fi8Y9606	intact-crc:35F721FA635772CA|rigid:EFgx7c0YcWNOqlrSiDvl/DZ77EI	false	-	sufficient binding region:20-757	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P35968	uniprotkb:P15692	intact:EBI-1005487|intact:EBI-28976571|ensembl:ENSP00000263923|uniprotkb:O60723|uniprotkb:Q14178|uniprotkb:A2RRS0|uniprotkb:B5A925|uniprotkb:C5IFA0	intact:EBI-1026643|uniprotkb:O60720|uniprotkb:O75875|uniprotkb:Q074Z4|uniprotkb:Q16889|uniprotkb:Q5UB46|uniprotkb:Q6P0P5|uniprotkb:Q96KJ0|uniprotkb:Q96L82|uniprotkb:Q96NW5|uniprotkb:Q9H1W8|uniprotkb:Q9H1W9|uniprotkb:Q9UH58|uniprotkb:Q9UL23|uniprotkb:B5BU86|ensembl:ENSP00000430479|uniprotkb:H0Y2S8|uniprotkb:H0Y407|uniprotkb:H0Y414|uniprotkb:H0Y462|uniprotkb:H0Y8N2|uniprotkb:H3BLW7	psi-mi:vgfr2_human(display_long)|uniprotkb:Kinase insert domain receptor(gene name synonym)|uniprotkb:Protein-tyrosine kinase receptor flk-1(gene name synonym)|uniprotkb:KDR(gene name)|psi-mi:KDR(display_short)|uniprotkb:FLK1(gene name synonym)|uniprotkb:Fetal liver kinase 1(gene name synonym)|uniprotkb:VEGFR2(gene name synonym)	psi-mi:vegfa_human(display_long)|uniprotkb:Vascular permeability factor(gene name synonym)|uniprotkb:VEGFA(gene name)|psi-mi:VEGFA(display_short)|uniprotkb:VEGF(gene name synonym)	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)	Mitola et al. (2010)	pubmed:20660291|imex:IM-22165	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-9098460|imex:IM-22165-6	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002244.1|ensembl:ENSP00000263923|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0016477"(cell migration)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019838"(growth factor binding)|go:"GO:0030054"(cell junction)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0035162"(embryonic hemopoiesis)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|go:"GO:0036324"(vascular endothelial growth factor receptor-2 signaling pathway)|go:"GO:0038033"(positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway)|go:"GO:0038083"(peptidyl-tyrosine autophosphorylation)|go:"GO:0038084"(vascular endothelial growth factor signaling pathway)|go:"GO:0038085"(vascular endothelial growth factor binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043235"(receptor complex)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0045121"(membrane raft)|go:"GO:0045296"(cadherin binding)|go:"GO:0045446"(endothelial cell differentiation)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|go:"GO:0050927"(positive regulation of positive chemotaxis)|go:"GO:0051770"(positive regulation of nitric-oxide synthase biosynthetic process)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0051901"(positive regulation of mitochondrial depolarization)|go:"GO:0061042"(vascular wound healing)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0090141"(positive regulation of mitochondrial fission)|go:"GO:0097443"(sorting endosome)|go:"GO:1904881"(cellular response to hydrogen sulfide)|go:"GO:2000352"(negative regulation of endothelial cell apoptotic process)|go:"GO:2001214"(positive regulation of vasculogenesis)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001824(Receptor tyrosine kinase, class III, conserved site)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR009136(Vascular endothelial growth factor receptor 2, VEGFR2)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR036179|interpro:IPR041348|go:"GO:0090050"(positive regulation of cell migration involved in sprouting angiogenesis)|mint:P35968|rcsb pdb:1VR2|rcsb pdb:1Y6A|rcsb pdb:1Y6B|rcsb pdb:1YWN|rcsb pdb:2M59|rcsb pdb:2MET|rcsb pdb:2MEU|rcsb pdb:2OH4|rcsb pdb:2P2H|rcsb pdb:2P2I|rcsb pdb:2QU5|rcsb pdb:2QU6|rcsb pdb:2RL5|rcsb pdb:2X1W|rcsb pdb:2X1X|rcsb pdb:2XIR|rcsb pdb:3B8Q|rcsb pdb:3B8R|rcsb pdb:3BE2|rcsb pdb:3C7Q|rcsb pdb:3CJF|rcsb pdb:3CJG|rcsb pdb:3CP9|rcsb pdb:3CPB|rcsb pdb:3CPC|rcsb pdb:3DTW|rcsb pdb:3EFL|rcsb pdb:3EWH|rcsb pdb:3KVQ|rcsb pdb:3S35|rcsb pdb:3S36|rcsb pdb:3S37|rcsb pdb:3U6J|rcsb pdb:3V2A|rcsb pdb:3V6B|rcsb pdb:3VHE|rcsb pdb:3VHK|rcsb pdb:3VID|rcsb pdb:3VNT|rcsb pdb:3VO3|rcsb pdb:3WZD|rcsb pdb:3WZE|rcsb pdb:4AG8|rcsb pdb:4AGC|rcsb pdb:4AGD|rcsb pdb:4ASD|rcsb pdb:4ASE|rcsb pdb:5EW3|rcsb pdb:5OYJ|rcsb pdb:6GQO|rcsb pdb:6GQP|rcsb pdb:6GQQ|rcsb pdb:6XVJ|rcsb pdb:6XVK|reactome:R-HSA-194306|reactome:R-HSA-195399|reactome:R-HSA-216083|reactome:R-HSA-4420097|reactome:R-HSA-5218921|reactome:R-HSA-9673768|ensembl:ENSG00000128052(gene)|ensembl:ENST00000263923(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001569"(branching involved in blood vessel morphogenesis)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0002042"(cell migration involved in sprouting angiogenesis)|go:"GO:0002244"(hematopoietic progenitor cell differentiation)|go:"GO:0003158"(endothelium development)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005021"(vascular endothelial growth factor-activated receptor activity)|go:"GO:0005178"(integrin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|dip:DIP-486N	refseq:NP_001020537.2|refseq:NP_001020538.2|refseq:NP_001020539.2|refseq:NP_001020540.2|refseq:NP_001020541.2|refseq:NP_001028928.1|refseq:NP_001165093.1|refseq:NP_001165094.1|refseq:NP_001165095.1|refseq:NP_001165096.1|refseq:NP_001165097.1|refseq:NP_001165098.1|refseq:NP_001165099.1|refseq:NP_001165100.1|refseq:NP_001165101.1|refseq:NP_001191313.1|refseq:NP_001191314.1|refseq:NP_003367.4|refseq:NP_001303939.1|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|go:"GO:0048018"(receptor ligand activity)|go:"GO:0048469"(cell maturation)|go:"GO:0048593"(camera-type eye morphogenesis)|go:"GO:0048842"(positive regulation of axon extension involved in axon guidance)|go:"GO:0048844"(artery morphogenesis)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050840"(extracellular matrix binding)|go:"GO:0050918"(positive chemotaxis)|go:"GO:0050927"(positive regulation of positive chemotaxis)|go:"GO:0050930"(induction of positive chemotaxis)|go:"GO:0051272"(positive regulation of cellular component movement)|go:"GO:0051781"(positive regulation of cell division)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0055013"(cardiac muscle cell development)|go:"GO:0060319"(primitive erythrocyte differentiation)|go:"GO:0060749"(mammary gland alveolus development)|go:"GO:0060754"(positive regulation of mast cell chemotaxis)|go:"GO:0060948"(cardiac vascular smooth muscle cell development)|go:"GO:0060982"(coronary artery morphogenesis)|go:"GO:0061042"(vascular wound healing)|go:"GO:0061419"(positive regulation of transcription from RNA polymerase II promoter in response to hypoxia)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071542"(dopaminergic neuron differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|ensembl:ENSG00000112715(gene)|ensembl:ENST00000523873(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001525"(angiogenesis)|go:"GO:0001541"(ovarian follicle development)|go:"GO:0001569"(branching involved in blood vessel morphogenesis)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001822"(kidney development)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0001968"(fibronectin binding)|go:"GO:0071679"(commissural neuron axon guidance)|go:"GO:0005125"(cytokine activity)|go:"GO:0005161"(platelet-derived growth factor receptor binding)|go:"GO:0002040"(sprouting angiogenesis)|go:"GO:0005172"(vascular endothelial growth factor receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005912"(adherens junction)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007399"(nervous system development)|go:"GO:0007498"(mesoderm development)|go:"GO:0007595"(lactation)|go:"GO:0008083"(growth factor activity)|go:"GO:0002042"(cell migration involved in sprouting angiogenesis)|go:"GO:0008201"(heparin binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0002052"(positive regulation of neuroblast proliferation)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0002575"(basophil chemotaxis)|go:"GO:0002687"(positive regulation of leukocyte migration)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0009986"(cell surface)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0003169"(coronary vein morphogenesis)|go:"GO:0010749"(regulation of nitric oxide mediated signal transduction)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016020"(membrane)|go:"GO:0030141"(secretory granule)|go:"GO:0030224"(monocyte differentiation)|go:"GO:0030225"(macrophage differentiation)|go:"GO:0030324"(lung development)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030855"(epithelial cell differentiation)|go:"GO:0031077"(post-embryonic camera-type eye development)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0031954"(positive regulation of protein autophosphorylation)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0032793"(positive regulation of CREB transcription factor activity)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0035148"(tube formation)|go:"GO:0035767"(endothelial cell chemotaxis)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|go:"GO:0036303"(lymph vessel morphogenesis)|go:"GO:0036324"(vascular endothelial growth factor receptor-2 signaling pathway)|go:"GO:0038033"(positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway)|go:"GO:0038084"(vascular endothelial growth factor signaling pathway)|go:"GO:0038089"(positive regulation of cell migration by vascular endothelial growth factor signaling pathway)|go:"GO:0038091"(positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway)|go:"GO:0038190"(VEGF-activated neuropilin signaling pathway)|go:"GO:0038191"(neuropilin binding)|go:"GO:0042056"(chemoattractant activity)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0031012"(extracellular matrix)|go:"GO:1903572"(positive regulation of protein kinase D signaling)|go:"GO:1903589"(positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis)|go:"GO:1903672"(positive regulation of sprouting angiogenesis)|go:"GO:1905278"(positive regulation of epithelial tube formation)|go:"GO:1905604"(negative regulation of blood-brain barrier permeability)|go:"GO:2000048"(negative regulation of cell-cell adhesion mediated by cadherin)|go:"GO:2000573"(positive regulation of DNA biosynthetic process)|interpro:IPR000072("Platelet-derived growth factor (PDGF)")|interpro:IPR023581|interpro:IPR027928|interpro:IPR029034|interpro:IPR036841|mint:P15692|rcsb pdb:1BJ1|go:"GO:1903392"(negative regulation of adherens junction organization)|go:"GO:0090050"(positive regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090190"(positive regulation of branching involved in ureteric bud morphogenesis)|go:"GO:0090259"(regulation of retinal ganglion cell axon guidance)|go:"GO:0097475"(motor neuron migration)|go:"GO:0097533"(cellular stress response to acid chemical)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1900086"(positive regulation of peptidyl-tyrosine autophosphorylation)|go:"GO:1900745"(positive regulation of p38MAPK cascade)|go:"GO:1901165"(positive regulation of trophoblast cell migration)|go:"GO:1901727"(positive regulation of histone deacetylase activity)|go:"GO:1902336"(positive regulation of retinal ganglion cell axon guidance)|go:"GO:1902966"(positive regulation of protein localization to early endosome)|go:"GO:1903141"(negative regulation of establishment of endothelial barrier)|go:"GO:0090037"(positive regulation of protein kinase C signaling)|rcsb pdb:1FLT|rcsb pdb:1KAT|rcsb pdb:1KMX|rcsb pdb:1MJV|rcsb pdb:1MKG|rcsb pdb:1MKK|rcsb pdb:1QTY|rcsb pdb:1TZH|rcsb pdb:1TZI|rcsb pdb:1VGH|rcsb pdb:1VPF|rcsb pdb:1VPP|rcsb pdb:2FJG|rcsb pdb:2FJH|rcsb pdb:2QR0|rcsb pdb:2VGH|rcsb pdb:2VPF|rcsb pdb:3BDY|rcsb pdb:3P9W|rcsb pdb:3QTK|rcsb pdb:3S1B|rcsb pdb:3S1K|rcsb pdb:3V2A|rcsb pdb:4DEQ|rcsb pdb:4GLN|rcsb pdb:4GLS|rcsb pdb:4KZN|rcsb pdb:4QAF|rcsb pdb:4WPB|rcsb pdb:4ZFF|rcsb pdb:5DN2|rcsb pdb:5FV1|rcsb pdb:5FV2|rcsb pdb:5HHC|rcsb pdb:5HHD|rcsb pdb:5O4E|rcsb pdb:1CZ8|rcsb pdb:5T89|rcsb pdb:6BFT|rcsb pdb:6D3O|rcsb pdb:6T9D|rcsb pdb:6V7K|rcsb pdb:6Z13|rcsb pdb:6Z3F|rcsb pdb:6ZBR|rcsb pdb:6ZCD|rcsb pdb:6ZFL|rcsb pdb:7LL9|reactome:R-HSA-114608|reactome:R-HSA-1234158|reactome:R-HSA-194138|reactome:R-HSA-194313|reactome:R-HSA-195399|reactome:R-HSA-4420097|reactome:R-HSA-5218921|reactome:R-HSA-6785807|reactome:R-HSA-8866910|reactome:R-HSA-9679191|rcsb pdb:7LL8|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043117"(positive regulation of vascular permeability)|go:"GO:0043129"(surfactant homeostasis)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043183"(vascular endothelial growth factor receptor 1 binding)|go:"GO:0043184"(vascular endothelial growth factor receptor 2 binding)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0042462"(eye photoreceptor cell development)|refseq:NP_001273973.1|dip:DIP-5740N	-	-	-	figure legend:Fig.1 C|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/01/13	2014/10/16	rogid:NnrnIZM28U6DGKYiDT9+sh/fi8Y9606	rogid:O5iw4Qx7W34QAg3oFkltpRxDYwA9606	intact-crc:22080FD4A09A446B|rigid:DC0aVx728alZcinltnpm6V3z4ho	false	sufficient binding region:20-757|fc-igg tag:?-?	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P35968	uniprotkb:O60565	intact:EBI-1005487|intact:EBI-28976571|ensembl:ENSP00000263923|uniprotkb:O60723|uniprotkb:Q14178|uniprotkb:A2RRS0|uniprotkb:B5A925|uniprotkb:C5IFA0	intact:EBI-944395|uniprotkb:Q52LV3|uniprotkb:Q8N914|uniprotkb:Q8N936|ensembl:ENSP00000300177|ensembl:ENSP00000498605|ensembl:ENSP00000498748|ensembl:ENSP00000498763|ensembl:ENSP00000498897	psi-mi:vgfr2_human(display_long)|uniprotkb:Kinase insert domain receptor(gene name synonym)|uniprotkb:Protein-tyrosine kinase receptor flk-1(gene name synonym)|uniprotkb:KDR(gene name)|psi-mi:KDR(display_short)|uniprotkb:FLK1(gene name synonym)|uniprotkb:Fetal liver kinase 1(gene name synonym)|uniprotkb:VEGFR2(gene name synonym)	psi-mi:grem1_human(display_long)|uniprotkb:GREM1(gene name)|psi-mi:GREM1(display_short)|uniprotkb:CKTSF1B1(gene name synonym)|uniprotkb:DAND2(gene name synonym)|uniprotkb:DRM(gene name synonym)|uniprotkb:PIG2(orf name)|uniprotkb:Cysteine knot superfamily 1, BMP antagonist 1(gene name synonym)|uniprotkb:Increased in high glucose protein 2(gene name synonym)|uniprotkb:Down-regulated in Mos-transformed cells protein(gene name synonym)|uniprotkb:DAN domain family member 2(gene name synonym)|uniprotkb:Cell proliferation-inducing gene 2 protein(gene name synonym)	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)	Mitola et al. (2010)	pubmed:20660291|imex:IM-22165	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-9098460|imex:IM-22165-6	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0941"(competitor)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002244.1|ensembl:ENSP00000263923|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0016477"(cell migration)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019838"(growth factor binding)|go:"GO:0030054"(cell junction)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0035162"(embryonic hemopoiesis)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|go:"GO:0036324"(vascular endothelial growth factor receptor-2 signaling pathway)|go:"GO:0038033"(positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway)|go:"GO:0038083"(peptidyl-tyrosine autophosphorylation)|go:"GO:0038084"(vascular endothelial growth factor signaling pathway)|go:"GO:0038085"(vascular endothelial growth factor binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043235"(receptor complex)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0045121"(membrane raft)|go:"GO:0045296"(cadherin binding)|go:"GO:0045446"(endothelial cell differentiation)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|go:"GO:0050927"(positive regulation of positive chemotaxis)|go:"GO:0051770"(positive regulation of nitric-oxide synthase biosynthetic process)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0051901"(positive regulation of mitochondrial depolarization)|go:"GO:0061042"(vascular wound healing)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0090141"(positive regulation of mitochondrial fission)|go:"GO:0097443"(sorting endosome)|go:"GO:1904881"(cellular response to hydrogen sulfide)|go:"GO:2000352"(negative regulation of endothelial cell apoptotic process)|go:"GO:2001214"(positive regulation of vasculogenesis)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001824(Receptor tyrosine kinase, class III, conserved site)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR009136(Vascular endothelial growth factor receptor 2, VEGFR2)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR036179|interpro:IPR041348|go:"GO:0090050"(positive regulation of cell migration involved in sprouting angiogenesis)|mint:P35968|rcsb pdb:1VR2|rcsb pdb:1Y6A|rcsb pdb:1Y6B|rcsb pdb:1YWN|rcsb pdb:2M59|rcsb pdb:2MET|rcsb pdb:2MEU|rcsb pdb:2OH4|rcsb pdb:2P2H|rcsb pdb:2P2I|rcsb pdb:2QU5|rcsb pdb:2QU6|rcsb pdb:2RL5|rcsb pdb:2X1W|rcsb pdb:2X1X|rcsb pdb:2XIR|rcsb pdb:3B8Q|rcsb pdb:3B8R|rcsb pdb:3BE2|rcsb pdb:3C7Q|rcsb pdb:3CJF|rcsb pdb:3CJG|rcsb pdb:3CP9|rcsb pdb:3CPB|rcsb pdb:3CPC|rcsb pdb:3DTW|rcsb pdb:3EFL|rcsb pdb:3EWH|rcsb pdb:3KVQ|rcsb pdb:3S35|rcsb pdb:3S36|rcsb pdb:3S37|rcsb pdb:3U6J|rcsb pdb:3V2A|rcsb pdb:3V6B|rcsb pdb:3VHE|rcsb pdb:3VHK|rcsb pdb:3VID|rcsb pdb:3VNT|rcsb pdb:3VO3|rcsb pdb:3WZD|rcsb pdb:3WZE|rcsb pdb:4AG8|rcsb pdb:4AGC|rcsb pdb:4AGD|rcsb pdb:4ASD|rcsb pdb:4ASE|rcsb pdb:5EW3|rcsb pdb:5OYJ|rcsb pdb:6GQO|rcsb pdb:6GQP|rcsb pdb:6GQQ|rcsb pdb:6XVJ|rcsb pdb:6XVK|reactome:R-HSA-194306|reactome:R-HSA-195399|reactome:R-HSA-216083|reactome:R-HSA-4420097|reactome:R-HSA-5218921|reactome:R-HSA-9673768|ensembl:ENSG00000128052(gene)|ensembl:ENST00000263923(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001569"(branching involved in blood vessel morphogenesis)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0002042"(cell migration involved in sprouting angiogenesis)|go:"GO:0002244"(hematopoietic progenitor cell differentiation)|go:"GO:0003158"(endothelium development)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005021"(vascular endothelial growth factor-activated receptor activity)|go:"GO:0005178"(integrin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|dip:DIP-486N	refseq:NP_001178252.1|refseq:NP_037504.1|go:"GO:0090190"(positive regulation of branching involved in ureteric bud morphogenesis)|go:"GO:0090291"(negative regulation of osteoclast proliferation)|go:"GO:1900086"(positive regulation of peptidyl-tyrosine autophosphorylation)|go:"GO:1900155"(negative regulation of bone trabecula formation)|go:"GO:1900158"(negative regulation of bone mineralization involved in bone maturation)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:2000273"(positive regulation of signaling receptor activity)|go:"GO:2000727"(positive regulation of cardiac muscle cell differentiation)|interpro:IPR004133(DAN)|interpro:IPR006207(Cystine knot, C-terminal)|interpro:IPR017159(Gremlin precursor)|interpro:IPR029034|rcsb pdb:5AEJ|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|ensembl:ENSG00000166923(gene)|ensembl:ENSG00000276886(gene)|ensembl:ENSG00000282046(gene)|ensembl:ENST00000300177(transcript)|ensembl:ENST00000651081(transcript)|ensembl:ENST00000651154(transcript)|ensembl:ENST00000651986(transcript)|ensembl:ENST00000652365(transcript)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0002042"(cell migration involved in sprouting angiogenesis)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0003257"(positive regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation)|go:"GO:0003337"(mesenchymal to epithelial transition involved in metanephros morphogenesis)|go:"GO:0005125"(cytokine activity)|go:"GO:0005615"(extracellular space)|go:"GO:0006915"(apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0009954"(proximal/distal pattern formation)|go:"GO:0009986"(cell surface)|go:"GO:0010717"(regulation of epithelial to mesenchymal transition)|go:"GO:0016015"(morphogen activity)|go:"GO:0030199"(collagen fibril organization)|go:"GO:0030297"(transmembrane receptor protein tyrosine kinase activator activity)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030326"(embryonic limb morphogenesis)|go:"GO:0030502"(negative regulation of bone mineralization)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0032331"(negative regulation of chondrocyte differentiation)|go:"GO:0033689"(negative regulation of osteoblast proliferation)|go:"GO:0036122"(BMP binding)|go:"GO:0038098"(sequestering of BMP from receptor via BMP binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043184"(vascular endothelial growth factor receptor 2 binding)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046851"(negative regulation of bone remodeling)|go:"GO:0048018"(receptor ligand activity)|go:"GO:0048263"(determination of dorsal identity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051893"(regulation of focal adhesion assembly)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0060173"(limb development)|go:"GO:0060394"(negative regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0060676"(ureteric bud formation)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0090027"(negative regulation of monocyte chemotaxis)	-	-	-	figure legend:Fig.1 C|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/01/13	2014/10/16	rogid:NnrnIZM28U6DGKYiDT9+sh/fi8Y9606	rogid:eo1SLD8rZOBrQBcawMffMRz4Ex09606	intact-crc:22080FD4A09A446B|rigid:DC0aVx728alZcinltnpm6V3z4ho	false	sufficient binding region:20-757|fc-igg tag:?-?	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P35968	uniprotkb:P15692	intact:EBI-1005487|intact:EBI-28976571|ensembl:ENSP00000263923|uniprotkb:O60723|uniprotkb:Q14178|uniprotkb:A2RRS0|uniprotkb:B5A925|uniprotkb:C5IFA0	intact:EBI-1026643|uniprotkb:O60720|uniprotkb:O75875|uniprotkb:Q074Z4|uniprotkb:Q16889|uniprotkb:Q5UB46|uniprotkb:Q6P0P5|uniprotkb:Q96KJ0|uniprotkb:Q96L82|uniprotkb:Q96NW5|uniprotkb:Q9H1W8|uniprotkb:Q9H1W9|uniprotkb:Q9UH58|uniprotkb:Q9UL23|uniprotkb:B5BU86|ensembl:ENSP00000430479|uniprotkb:H0Y2S8|uniprotkb:H0Y407|uniprotkb:H0Y414|uniprotkb:H0Y462|uniprotkb:H0Y8N2|uniprotkb:H3BLW7	psi-mi:vgfr2_human(display_long)|uniprotkb:Kinase insert domain receptor(gene name synonym)|uniprotkb:Protein-tyrosine kinase receptor flk-1(gene name synonym)|uniprotkb:KDR(gene name)|psi-mi:KDR(display_short)|uniprotkb:FLK1(gene name synonym)|uniprotkb:Fetal liver kinase 1(gene name synonym)|uniprotkb:VEGFR2(gene name synonym)	psi-mi:vegfa_human(display_long)|uniprotkb:Vascular permeability factor(gene name synonym)|uniprotkb:VEGFA(gene name)|psi-mi:VEGFA(display_short)|uniprotkb:VEGF(gene name synonym)	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)	Mitola et al. (2010)	pubmed:20660291|imex:IM-22165	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-9098452|imex:IM-22165-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002244.1|ensembl:ENSP00000263923|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0016477"(cell migration)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019838"(growth factor binding)|go:"GO:0030054"(cell junction)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0035162"(embryonic hemopoiesis)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|go:"GO:0036324"(vascular endothelial growth factor receptor-2 signaling pathway)|go:"GO:0038033"(positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway)|go:"GO:0038083"(peptidyl-tyrosine autophosphorylation)|go:"GO:0038084"(vascular endothelial growth factor signaling pathway)|go:"GO:0038085"(vascular endothelial growth factor binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043235"(receptor complex)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0045121"(membrane raft)|go:"GO:0045296"(cadherin binding)|go:"GO:0045446"(endothelial cell differentiation)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|go:"GO:0050927"(positive regulation of positive chemotaxis)|go:"GO:0051770"(positive regulation of nitric-oxide synthase biosynthetic process)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0051901"(positive regulation of mitochondrial depolarization)|go:"GO:0061042"(vascular wound healing)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0090141"(positive regulation of mitochondrial fission)|go:"GO:0097443"(sorting endosome)|go:"GO:1904881"(cellular response to hydrogen sulfide)|go:"GO:2000352"(negative regulation of endothelial cell apoptotic process)|go:"GO:2001214"(positive regulation of vasculogenesis)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001824(Receptor tyrosine kinase, class III, conserved site)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR009136(Vascular endothelial growth factor receptor 2, VEGFR2)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR036179|interpro:IPR041348|go:"GO:0090050"(positive regulation of cell migration involved in sprouting angiogenesis)|mint:P35968|rcsb pdb:1VR2|rcsb pdb:1Y6A|rcsb pdb:1Y6B|rcsb pdb:1YWN|rcsb pdb:2M59|rcsb pdb:2MET|rcsb pdb:2MEU|rcsb pdb:2OH4|rcsb pdb:2P2H|rcsb pdb:2P2I|rcsb pdb:2QU5|rcsb pdb:2QU6|rcsb pdb:2RL5|rcsb pdb:2X1W|rcsb pdb:2X1X|rcsb pdb:2XIR|rcsb pdb:3B8Q|rcsb pdb:3B8R|rcsb pdb:3BE2|rcsb pdb:3C7Q|rcsb pdb:3CJF|rcsb pdb:3CJG|rcsb pdb:3CP9|rcsb pdb:3CPB|rcsb pdb:3CPC|rcsb pdb:3DTW|rcsb pdb:3EFL|rcsb pdb:3EWH|rcsb pdb:3KVQ|rcsb pdb:3S35|rcsb pdb:3S36|rcsb pdb:3S37|rcsb pdb:3U6J|rcsb pdb:3V2A|rcsb pdb:3V6B|rcsb pdb:3VHE|rcsb pdb:3VHK|rcsb pdb:3VID|rcsb pdb:3VNT|rcsb pdb:3VO3|rcsb pdb:3WZD|rcsb pdb:3WZE|rcsb pdb:4AG8|rcsb pdb:4AGC|rcsb pdb:4AGD|rcsb pdb:4ASD|rcsb pdb:4ASE|rcsb pdb:5EW3|rcsb pdb:5OYJ|rcsb pdb:6GQO|rcsb pdb:6GQP|rcsb pdb:6GQQ|rcsb pdb:6XVJ|rcsb pdb:6XVK|reactome:R-HSA-194306|reactome:R-HSA-195399|reactome:R-HSA-216083|reactome:R-HSA-4420097|reactome:R-HSA-5218921|reactome:R-HSA-9673768|ensembl:ENSG00000128052(gene)|ensembl:ENST00000263923(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001569"(branching involved in blood vessel morphogenesis)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0002042"(cell migration involved in sprouting angiogenesis)|go:"GO:0002244"(hematopoietic progenitor cell differentiation)|go:"GO:0003158"(endothelium development)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005021"(vascular endothelial growth factor-activated receptor activity)|go:"GO:0005178"(integrin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|dip:DIP-486N	refseq:NP_001020537.2|refseq:NP_001020538.2|refseq:NP_001020539.2|refseq:NP_001020540.2|refseq:NP_001020541.2|refseq:NP_001028928.1|refseq:NP_001165093.1|refseq:NP_001165094.1|refseq:NP_001165095.1|refseq:NP_001165096.1|refseq:NP_001165097.1|refseq:NP_001165098.1|refseq:NP_001165099.1|refseq:NP_001165100.1|refseq:NP_001165101.1|refseq:NP_001191313.1|refseq:NP_001191314.1|refseq:NP_003367.4|refseq:NP_001303939.1|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|go:"GO:0048018"(receptor ligand activity)|go:"GO:0048469"(cell maturation)|go:"GO:0048593"(camera-type eye morphogenesis)|go:"GO:0048842"(positive regulation of axon extension involved in axon guidance)|go:"GO:0048844"(artery morphogenesis)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050840"(extracellular matrix binding)|go:"GO:0050918"(positive chemotaxis)|go:"GO:0050927"(positive regulation of positive chemotaxis)|go:"GO:0050930"(induction of positive chemotaxis)|go:"GO:0051272"(positive regulation of cellular component movement)|go:"GO:0051781"(positive regulation of cell division)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0055013"(cardiac muscle cell development)|go:"GO:0060319"(primitive erythrocyte differentiation)|go:"GO:0060749"(mammary gland alveolus development)|go:"GO:0060754"(positive regulation of mast cell chemotaxis)|go:"GO:0060948"(cardiac vascular smooth muscle cell development)|go:"GO:0060982"(coronary artery morphogenesis)|go:"GO:0061042"(vascular wound healing)|go:"GO:0061419"(positive regulation of transcription from RNA polymerase II promoter in response to hypoxia)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071542"(dopaminergic neuron differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|ensembl:ENSG00000112715(gene)|ensembl:ENST00000523873(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001525"(angiogenesis)|go:"GO:0001541"(ovarian follicle development)|go:"GO:0001569"(branching involved in blood vessel morphogenesis)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001822"(kidney development)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0001968"(fibronectin binding)|go:"GO:0071679"(commissural neuron axon guidance)|go:"GO:0005125"(cytokine activity)|go:"GO:0005161"(platelet-derived growth factor receptor binding)|go:"GO:0002040"(sprouting angiogenesis)|go:"GO:0005172"(vascular endothelial growth factor receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005912"(adherens junction)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007399"(nervous system development)|go:"GO:0007498"(mesoderm development)|go:"GO:0007595"(lactation)|go:"GO:0008083"(growth factor activity)|go:"GO:0002042"(cell migration involved in sprouting angiogenesis)|go:"GO:0008201"(heparin binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0002052"(positive regulation of neuroblast proliferation)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0002575"(basophil chemotaxis)|go:"GO:0002687"(positive regulation of leukocyte migration)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0009986"(cell surface)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0003169"(coronary vein morphogenesis)|go:"GO:0010749"(regulation of nitric oxide mediated signal transduction)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016020"(membrane)|go:"GO:0030141"(secretory granule)|go:"GO:0030224"(monocyte differentiation)|go:"GO:0030225"(macrophage differentiation)|go:"GO:0030324"(lung development)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030855"(epithelial cell differentiation)|go:"GO:0031077"(post-embryonic camera-type eye development)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0031954"(positive regulation of protein autophosphorylation)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0032793"(positive regulation of CREB transcription factor activity)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0035148"(tube formation)|go:"GO:0035767"(endothelial cell chemotaxis)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|go:"GO:0036303"(lymph vessel morphogenesis)|go:"GO:0036324"(vascular endothelial growth factor receptor-2 signaling pathway)|go:"GO:0038033"(positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway)|go:"GO:0038084"(vascular endothelial growth factor signaling pathway)|go:"GO:0038089"(positive regulation of cell migration by vascular endothelial growth factor signaling pathway)|go:"GO:0038091"(positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway)|go:"GO:0038190"(VEGF-activated neuropilin signaling pathway)|go:"GO:0038191"(neuropilin binding)|go:"GO:0042056"(chemoattractant activity)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0031012"(extracellular matrix)|go:"GO:1903572"(positive regulation of protein kinase D signaling)|go:"GO:1903589"(positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis)|go:"GO:1903672"(positive regulation of sprouting angiogenesis)|go:"GO:1905278"(positive regulation of epithelial tube formation)|go:"GO:1905604"(negative regulation of blood-brain barrier permeability)|go:"GO:2000048"(negative regulation of cell-cell adhesion mediated by cadherin)|go:"GO:2000573"(positive regulation of DNA biosynthetic process)|interpro:IPR000072("Platelet-derived growth factor (PDGF)")|interpro:IPR023581|interpro:IPR027928|interpro:IPR029034|interpro:IPR036841|mint:P15692|rcsb pdb:1BJ1|go:"GO:1903392"(negative regulation of adherens junction organization)|go:"GO:0090050"(positive regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090190"(positive regulation of branching involved in ureteric bud morphogenesis)|go:"GO:0090259"(regulation of retinal ganglion cell axon guidance)|go:"GO:0097475"(motor neuron migration)|go:"GO:0097533"(cellular stress response to acid chemical)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1900086"(positive regulation of peptidyl-tyrosine autophosphorylation)|go:"GO:1900745"(positive regulation of p38MAPK cascade)|go:"GO:1901165"(positive regulation of trophoblast cell migration)|go:"GO:1901727"(positive regulation of histone deacetylase activity)|go:"GO:1902336"(positive regulation of retinal ganglion cell axon guidance)|go:"GO:1902966"(positive regulation of protein localization to early endosome)|go:"GO:1903141"(negative regulation of establishment of endothelial barrier)|go:"GO:0090037"(positive regulation of protein kinase C signaling)|rcsb pdb:1FLT|rcsb pdb:1KAT|rcsb pdb:1KMX|rcsb pdb:1MJV|rcsb pdb:1MKG|rcsb pdb:1MKK|rcsb pdb:1QTY|rcsb pdb:1TZH|rcsb pdb:1TZI|rcsb pdb:1VGH|rcsb pdb:1VPF|rcsb pdb:1VPP|rcsb pdb:2FJG|rcsb pdb:2FJH|rcsb pdb:2QR0|rcsb pdb:2VGH|rcsb pdb:2VPF|rcsb pdb:3BDY|rcsb pdb:3P9W|rcsb pdb:3QTK|rcsb pdb:3S1B|rcsb pdb:3S1K|rcsb pdb:3V2A|rcsb pdb:4DEQ|rcsb pdb:4GLN|rcsb pdb:4GLS|rcsb pdb:4KZN|rcsb pdb:4QAF|rcsb pdb:4WPB|rcsb pdb:4ZFF|rcsb pdb:5DN2|rcsb pdb:5FV1|rcsb pdb:5FV2|rcsb pdb:5HHC|rcsb pdb:5HHD|rcsb pdb:5O4E|rcsb pdb:1CZ8|rcsb pdb:5T89|rcsb pdb:6BFT|rcsb pdb:6D3O|rcsb pdb:6T9D|rcsb pdb:6V7K|rcsb pdb:6Z13|rcsb pdb:6Z3F|rcsb pdb:6ZBR|rcsb pdb:6ZCD|rcsb pdb:6ZFL|rcsb pdb:7LL9|reactome:R-HSA-114608|reactome:R-HSA-1234158|reactome:R-HSA-194138|reactome:R-HSA-194313|reactome:R-HSA-195399|reactome:R-HSA-4420097|reactome:R-HSA-5218921|reactome:R-HSA-6785807|reactome:R-HSA-8866910|reactome:R-HSA-9679191|rcsb pdb:7LL8|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043117"(positive regulation of vascular permeability)|go:"GO:0043129"(surfactant homeostasis)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043183"(vascular endothelial growth factor receptor 1 binding)|go:"GO:0043184"(vascular endothelial growth factor receptor 2 binding)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0042462"(eye photoreceptor cell development)|refseq:NP_001273973.1|dip:DIP-5740N	-	-	-	figure legend:Fig.1 C|causality statement:P15692 increases activity of P35968|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/01/13	2014/10/16	rogid:NnrnIZM28U6DGKYiDT9+sh/fi8Y9606	rogid:O5iw4Qx7W34QAg3oFkltpRxDYwA9606	intact-crc:6798FA70CC652A24|rigid:8ON4ZuFfVgOYCNXTgJh4JNQyWCo	false	fc-igg tag:?-?|sufficient binding region:20-757	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P15692	uniprotkb:P17948	intact:EBI-1026643|uniprotkb:O60720|uniprotkb:O75875|uniprotkb:Q074Z4|uniprotkb:Q16889|uniprotkb:Q5UB46|uniprotkb:Q6P0P5|uniprotkb:Q96KJ0|uniprotkb:Q96L82|uniprotkb:Q96NW5|uniprotkb:Q9H1W8|uniprotkb:Q9H1W9|uniprotkb:Q9UH58|uniprotkb:Q9UL23|uniprotkb:B5BU86|ensembl:ENSP00000430479|uniprotkb:H0Y2S8|uniprotkb:H0Y407|uniprotkb:H0Y414|uniprotkb:H0Y462|uniprotkb:H0Y8N2|uniprotkb:H3BLW7	intact:EBI-1026718|uniprotkb:B0LPF1|uniprotkb:B3FR89|uniprotkb:B5A923|uniprotkb:O60722|uniprotkb:P16057|uniprotkb:Q12954|uniprotkb:A8KA71|ensembl:ENSP00000282397|uniprotkb:A3E342|uniprotkb:A3E344|uniprotkb:B2BF46|uniprotkb:B2BF47|uniprotkb:F5H5L6|uniprotkb:B2BF48	psi-mi:vegfa_human(display_long)|uniprotkb:Vascular permeability factor(gene name synonym)|uniprotkb:VEGFA(gene name)|psi-mi:VEGFA(display_short)|uniprotkb:VEGF(gene name synonym)	psi-mi:vgfr1_human(display_long)|uniprotkb:Vascular permeability factor receptor(gene name synonym)|uniprotkb:Tyrosine-protein kinase receptor FLT(gene name synonym)|uniprotkb:Tyrosine-protein kinase FRT(gene name synonym)|uniprotkb:Fms-like tyrosine kinase 1(gene name synonym)|uniprotkb:FLT1(gene name)|psi-mi:FLT1(display_short)|uniprotkb:FLT(gene name synonym)|uniprotkb:FRT(gene name synonym)|uniprotkb:VEGFR1(gene name synonym)	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)	Mitola et al. (2010)	pubmed:20660291|imex:IM-22165	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-9084618|imex:IM-22165-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001020537.2|refseq:NP_001020538.2|refseq:NP_001020539.2|refseq:NP_001020540.2|refseq:NP_001020541.2|refseq:NP_001028928.1|refseq:NP_001165093.1|refseq:NP_001165094.1|refseq:NP_001165095.1|refseq:NP_001165096.1|refseq:NP_001165097.1|refseq:NP_001165098.1|refseq:NP_001165099.1|refseq:NP_001165100.1|refseq:NP_001165101.1|refseq:NP_001191313.1|refseq:NP_001191314.1|refseq:NP_003367.4|refseq:NP_001303939.1|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|go:"GO:0048018"(receptor ligand activity)|go:"GO:0048469"(cell maturation)|go:"GO:0048593"(camera-type eye morphogenesis)|go:"GO:0048842"(positive regulation of axon extension involved in axon guidance)|go:"GO:0048844"(artery morphogenesis)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050840"(extracellular matrix binding)|go:"GO:0050918"(positive chemotaxis)|go:"GO:0050927"(positive regulation of positive chemotaxis)|go:"GO:0050930"(induction of positive chemotaxis)|go:"GO:0051272"(positive regulation of cellular component movement)|go:"GO:0051781"(positive regulation of cell division)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0055013"(cardiac muscle cell development)|go:"GO:0060319"(primitive erythrocyte differentiation)|go:"GO:0060749"(mammary gland alveolus development)|go:"GO:0060754"(positive regulation of mast cell chemotaxis)|go:"GO:0060948"(cardiac vascular smooth muscle cell development)|go:"GO:0060982"(coronary artery morphogenesis)|go:"GO:0061042"(vascular wound healing)|go:"GO:0061419"(positive regulation of transcription from RNA polymerase II promoter in response to hypoxia)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071542"(dopaminergic neuron differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|ensembl:ENSG00000112715(gene)|ensembl:ENST00000523873(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001525"(angiogenesis)|go:"GO:0001541"(ovarian follicle development)|go:"GO:0001569"(branching involved in blood vessel morphogenesis)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001822"(kidney development)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0001968"(fibronectin binding)|go:"GO:0071679"(commissural neuron axon guidance)|go:"GO:0005125"(cytokine activity)|go:"GO:0005161"(platelet-derived growth factor receptor binding)|go:"GO:0002040"(sprouting angiogenesis)|go:"GO:0005172"(vascular endothelial growth factor receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005912"(adherens junction)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007399"(nervous system development)|go:"GO:0007498"(mesoderm development)|go:"GO:0007595"(lactation)|go:"GO:0008083"(growth factor activity)|go:"GO:0002042"(cell migration involved in sprouting angiogenesis)|go:"GO:0008201"(heparin binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0002052"(positive regulation of neuroblast proliferation)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0002575"(basophil chemotaxis)|go:"GO:0002687"(positive regulation of leukocyte migration)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0009986"(cell surface)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0003169"(coronary vein morphogenesis)|go:"GO:0010749"(regulation of nitric oxide mediated signal transduction)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016020"(membrane)|go:"GO:0030141"(secretory granule)|go:"GO:0030224"(monocyte differentiation)|go:"GO:0030225"(macrophage differentiation)|go:"GO:0030324"(lung development)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030855"(epithelial cell differentiation)|go:"GO:0031077"(post-embryonic camera-type eye development)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0031954"(positive regulation of protein autophosphorylation)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0032793"(positive regulation of CREB transcription factor activity)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0035148"(tube formation)|go:"GO:0035767"(endothelial cell chemotaxis)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|go:"GO:0036303"(lymph vessel morphogenesis)|go:"GO:0036324"(vascular endothelial growth factor receptor-2 signaling pathway)|go:"GO:0038033"(positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway)|go:"GO:0038084"(vascular endothelial growth factor signaling pathway)|go:"GO:0038089"(positive regulation of cell migration by vascular endothelial growth factor signaling pathway)|go:"GO:0038091"(positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway)|go:"GO:0038190"(VEGF-activated neuropilin signaling pathway)|go:"GO:0038191"(neuropilin binding)|go:"GO:0042056"(chemoattractant activity)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0031012"(extracellular matrix)|go:"GO:1903572"(positive regulation of protein kinase D signaling)|go:"GO:1903589"(positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis)|go:"GO:1903672"(positive regulation of sprouting angiogenesis)|go:"GO:1905278"(positive regulation of epithelial tube formation)|go:"GO:1905604"(negative regulation of blood-brain barrier permeability)|go:"GO:2000048"(negative regulation of cell-cell adhesion mediated by cadherin)|go:"GO:2000573"(positive regulation of DNA biosynthetic process)|interpro:IPR000072("Platelet-derived growth factor (PDGF)")|interpro:IPR023581|interpro:IPR027928|interpro:IPR029034|interpro:IPR036841|mint:P15692|rcsb pdb:1BJ1|go:"GO:1903392"(negative regulation of adherens junction organization)|go:"GO:0090050"(positive regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090190"(positive regulation of branching involved in ureteric bud morphogenesis)|go:"GO:0090259"(regulation of retinal ganglion cell axon guidance)|go:"GO:0097475"(motor neuron migration)|go:"GO:0097533"(cellular stress response to acid chemical)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1900086"(positive regulation of peptidyl-tyrosine autophosphorylation)|go:"GO:1900745"(positive regulation of p38MAPK cascade)|go:"GO:1901165"(positive regulation of trophoblast cell migration)|go:"GO:1901727"(positive regulation of histone deacetylase activity)|go:"GO:1902336"(positive regulation of retinal ganglion cell axon guidance)|go:"GO:1902966"(positive regulation of protein localization to early endosome)|go:"GO:1903141"(negative regulation of establishment of endothelial barrier)|go:"GO:0090037"(positive regulation of protein kinase C signaling)|rcsb pdb:1FLT|rcsb pdb:1KAT|rcsb pdb:1KMX|rcsb pdb:1MJV|rcsb pdb:1MKG|rcsb pdb:1MKK|rcsb pdb:1QTY|rcsb pdb:1TZH|rcsb pdb:1TZI|rcsb pdb:1VGH|rcsb pdb:1VPF|rcsb pdb:1VPP|rcsb pdb:2FJG|rcsb pdb:2FJH|rcsb pdb:2QR0|rcsb pdb:2VGH|rcsb pdb:2VPF|rcsb pdb:3BDY|rcsb pdb:3P9W|rcsb pdb:3QTK|rcsb pdb:3S1B|rcsb pdb:3S1K|rcsb pdb:3V2A|rcsb pdb:4DEQ|rcsb pdb:4GLN|rcsb pdb:4GLS|rcsb pdb:4KZN|rcsb pdb:4QAF|rcsb pdb:4WPB|rcsb pdb:4ZFF|rcsb pdb:5DN2|rcsb pdb:5FV1|rcsb pdb:5FV2|rcsb pdb:5HHC|rcsb pdb:5HHD|rcsb pdb:5O4E|rcsb pdb:1CZ8|rcsb pdb:5T89|rcsb pdb:6BFT|rcsb pdb:6D3O|rcsb pdb:6T9D|rcsb pdb:6V7K|rcsb pdb:6Z13|rcsb pdb:6Z3F|rcsb pdb:6ZBR|rcsb pdb:6ZCD|rcsb pdb:6ZFL|rcsb pdb:7LL9|reactome:R-HSA-114608|reactome:R-HSA-1234158|reactome:R-HSA-194138|reactome:R-HSA-194313|reactome:R-HSA-195399|reactome:R-HSA-4420097|reactome:R-HSA-5218921|reactome:R-HSA-6785807|reactome:R-HSA-8866910|reactome:R-HSA-9679191|rcsb pdb:7LL8|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043117"(positive regulation of vascular permeability)|go:"GO:0043129"(surfactant homeostasis)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043183"(vascular endothelial growth factor receptor 1 binding)|go:"GO:0043184"(vascular endothelial growth factor receptor 2 binding)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0042462"(eye photoreceptor cell development)|refseq:NP_001273973.1|dip:DIP-5740N	refseq:NP_001153392.1|refseq:NP_002010.2|ensembl:ENSG00000102755(gene)|ensembl:ENST00000282397(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005021"(vascular endothelial growth factor-activated receptor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005768"(endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010863"(positive regulation of phospholipase C activity)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016477"(cell migration)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019838"(growth factor binding)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|go:"GO:0036323"(vascular endothelial growth factor receptor-1 signaling pathway)|go:"GO:0036332"(placental growth factor-activated receptor activity)|go:"GO:0002244"(hematopoietic progenitor cell differentiation)|go:"GO:0043235"(receptor complex)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|go:"GO:0048514"(blood vessel morphogenesis)|go:"GO:0048598"(embryonic morphogenesis)|go:"GO:1905563"(negative regulation of vascular endothelial cell proliferation)|go:"GO:1990384"(hyaloid vascular plexus regression)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001824(Receptor tyrosine kinase, class III, conserved site)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR009135(Vascular endothelial growth factor receptor 1, VEGFR1, N-terminal)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR036179|mint:P17948|rcsb pdb:1FLT|rcsb pdb:1QSV|rcsb pdb:1QSZ|rcsb pdb:1QTY|rcsb pdb:1RV6|rcsb pdb:2XAC|rcsb pdb:3HNG|rcsb pdb:4CKV|rcsb pdb:4CL7|rcsb pdb:5ABD|rcsb pdb:5EX3|rcsb pdb:5T89|reactome:R-HSA-194306|reactome:R-HSA-195399|interpro:IPR041348|refseq:NP_001153502.1|refseq:NP_001153503.1|dip:DIP-643N	-	-	comment:"sVEGFR1fc (P17948) used in this experiment is a commercial one from RELIATech GmbH. It has an extra aminoacid (Arg) between  Thr751 and Ser752"	figure legend:Fig.1C|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/01/13	2014/10/16	rogid:O5iw4Qx7W34QAg3oFkltpRxDYwA9606	rogid:AfSO/WFuXISaK/PbB/s2Vv+vLFE9606	intact-crc:A7AC596CA1704746|rigid:QT3Mmm7I/sdXQixsxUQD5ObUQ34	false	-	sufficient binding region:27-756|fc-igg tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P17948	uniprotkb:P15692	intact:EBI-1026718|uniprotkb:B0LPF1|uniprotkb:B3FR89|uniprotkb:B5A923|uniprotkb:O60722|uniprotkb:P16057|uniprotkb:Q12954|uniprotkb:A8KA71|ensembl:ENSP00000282397|uniprotkb:A3E342|uniprotkb:A3E344|uniprotkb:B2BF46|uniprotkb:B2BF47|uniprotkb:F5H5L6|uniprotkb:B2BF48	intact:EBI-1026643|uniprotkb:O60720|uniprotkb:O75875|uniprotkb:Q074Z4|uniprotkb:Q16889|uniprotkb:Q5UB46|uniprotkb:Q6P0P5|uniprotkb:Q96KJ0|uniprotkb:Q96L82|uniprotkb:Q96NW5|uniprotkb:Q9H1W8|uniprotkb:Q9H1W9|uniprotkb:Q9UH58|uniprotkb:Q9UL23|uniprotkb:B5BU86|ensembl:ENSP00000430479|uniprotkb:H0Y2S8|uniprotkb:H0Y407|uniprotkb:H0Y414|uniprotkb:H0Y462|uniprotkb:H0Y8N2|uniprotkb:H3BLW7	psi-mi:vgfr1_human(display_long)|uniprotkb:Vascular permeability factor receptor(gene name synonym)|uniprotkb:Tyrosine-protein kinase receptor FLT(gene name synonym)|uniprotkb:Tyrosine-protein kinase FRT(gene name synonym)|uniprotkb:Fms-like tyrosine kinase 1(gene name synonym)|uniprotkb:FLT1(gene name)|psi-mi:FLT1(display_short)|uniprotkb:FLT(gene name synonym)|uniprotkb:FRT(gene name synonym)|uniprotkb:VEGFR1(gene name synonym)	psi-mi:vegfa_human(display_long)|uniprotkb:Vascular permeability factor(gene name synonym)|uniprotkb:VEGFA(gene name)|psi-mi:VEGFA(display_short)|uniprotkb:VEGF(gene name synonym)	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)	Mitola et al. (2010)	pubmed:20660291|imex:IM-22165	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-9098469|imex:IM-22165-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001153392.1|refseq:NP_002010.2|ensembl:ENSG00000102755(gene)|ensembl:ENST00000282397(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005021"(vascular endothelial growth factor-activated receptor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005768"(endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010863"(positive regulation of phospholipase C activity)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016477"(cell migration)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019838"(growth factor binding)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|go:"GO:0036323"(vascular endothelial growth factor receptor-1 signaling pathway)|go:"GO:0036332"(placental growth factor-activated receptor activity)|go:"GO:0002244"(hematopoietic progenitor cell differentiation)|go:"GO:0043235"(receptor complex)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|go:"GO:0048514"(blood vessel morphogenesis)|go:"GO:0048598"(embryonic morphogenesis)|go:"GO:1905563"(negative regulation of vascular endothelial cell proliferation)|go:"GO:1990384"(hyaloid vascular plexus regression)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001824(Receptor tyrosine kinase, class III, conserved site)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR009135(Vascular endothelial growth factor receptor 1, VEGFR1, N-terminal)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR036179|mint:P17948|rcsb pdb:1FLT|rcsb pdb:1QSV|rcsb pdb:1QSZ|rcsb pdb:1QTY|rcsb pdb:1RV6|rcsb pdb:2XAC|rcsb pdb:3HNG|rcsb pdb:4CKV|rcsb pdb:4CL7|rcsb pdb:5ABD|rcsb pdb:5EX3|rcsb pdb:5T89|reactome:R-HSA-194306|reactome:R-HSA-195399|interpro:IPR041348|refseq:NP_001153502.1|refseq:NP_001153503.1|dip:DIP-643N	refseq:NP_001020537.2|refseq:NP_001020538.2|refseq:NP_001020539.2|refseq:NP_001020540.2|refseq:NP_001020541.2|refseq:NP_001028928.1|refseq:NP_001165093.1|refseq:NP_001165094.1|refseq:NP_001165095.1|refseq:NP_001165096.1|refseq:NP_001165097.1|refseq:NP_001165098.1|refseq:NP_001165099.1|refseq:NP_001165100.1|refseq:NP_001165101.1|refseq:NP_001191313.1|refseq:NP_001191314.1|refseq:NP_003367.4|refseq:NP_001303939.1|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|go:"GO:0048018"(receptor ligand activity)|go:"GO:0048469"(cell maturation)|go:"GO:0048593"(camera-type eye morphogenesis)|go:"GO:0048842"(positive regulation of axon extension involved in axon guidance)|go:"GO:0048844"(artery morphogenesis)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050840"(extracellular matrix binding)|go:"GO:0050918"(positive chemotaxis)|go:"GO:0050927"(positive regulation of positive chemotaxis)|go:"GO:0050930"(induction of positive chemotaxis)|go:"GO:0051272"(positive regulation of cellular component movement)|go:"GO:0051781"(positive regulation of cell division)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0055013"(cardiac muscle cell development)|go:"GO:0060319"(primitive erythrocyte differentiation)|go:"GO:0060749"(mammary gland alveolus development)|go:"GO:0060754"(positive regulation of mast cell chemotaxis)|go:"GO:0060948"(cardiac vascular smooth muscle cell development)|go:"GO:0060982"(coronary artery morphogenesis)|go:"GO:0061042"(vascular wound healing)|go:"GO:0061419"(positive regulation of transcription from RNA polymerase II promoter in response to hypoxia)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071542"(dopaminergic neuron differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|ensembl:ENSG00000112715(gene)|ensembl:ENST00000523873(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001525"(angiogenesis)|go:"GO:0001541"(ovarian follicle development)|go:"GO:0001569"(branching involved in blood vessel morphogenesis)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001822"(kidney development)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0001968"(fibronectin binding)|go:"GO:0071679"(commissural neuron axon guidance)|go:"GO:0005125"(cytokine activity)|go:"GO:0005161"(platelet-derived growth factor receptor binding)|go:"GO:0002040"(sprouting angiogenesis)|go:"GO:0005172"(vascular endothelial growth factor receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005912"(adherens junction)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007399"(nervous system development)|go:"GO:0007498"(mesoderm development)|go:"GO:0007595"(lactation)|go:"GO:0008083"(growth factor activity)|go:"GO:0002042"(cell migration involved in sprouting angiogenesis)|go:"GO:0008201"(heparin binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0002052"(positive regulation of neuroblast proliferation)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0002575"(basophil chemotaxis)|go:"GO:0002687"(positive regulation of leukocyte migration)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0009986"(cell surface)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0003169"(coronary vein morphogenesis)|go:"GO:0010749"(regulation of nitric oxide mediated signal transduction)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016020"(membrane)|go:"GO:0030141"(secretory granule)|go:"GO:0030224"(monocyte differentiation)|go:"GO:0030225"(macrophage differentiation)|go:"GO:0030324"(lung development)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030855"(epithelial cell differentiation)|go:"GO:0031077"(post-embryonic camera-type eye development)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0031954"(positive regulation of protein autophosphorylation)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0032793"(positive regulation of CREB transcription factor activity)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0035148"(tube formation)|go:"GO:0035767"(endothelial cell chemotaxis)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|go:"GO:0036303"(lymph vessel morphogenesis)|go:"GO:0036324"(vascular endothelial growth factor receptor-2 signaling pathway)|go:"GO:0038033"(positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway)|go:"GO:0038084"(vascular endothelial growth factor signaling pathway)|go:"GO:0038089"(positive regulation of cell migration by vascular endothelial growth factor signaling pathway)|go:"GO:0038091"(positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway)|go:"GO:0038190"(VEGF-activated neuropilin signaling pathway)|go:"GO:0038191"(neuropilin binding)|go:"GO:0042056"(chemoattractant activity)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0031012"(extracellular matrix)|go:"GO:1903572"(positive regulation of protein kinase D signaling)|go:"GO:1903589"(positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis)|go:"GO:1903672"(positive regulation of sprouting angiogenesis)|go:"GO:1905278"(positive regulation of epithelial tube formation)|go:"GO:1905604"(negative regulation of blood-brain barrier permeability)|go:"GO:2000048"(negative regulation of cell-cell adhesion mediated by cadherin)|go:"GO:2000573"(positive regulation of DNA biosynthetic process)|interpro:IPR000072("Platelet-derived growth factor (PDGF)")|interpro:IPR023581|interpro:IPR027928|interpro:IPR029034|interpro:IPR036841|mint:P15692|rcsb pdb:1BJ1|go:"GO:1903392"(negative regulation of adherens junction organization)|go:"GO:0090050"(positive regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090190"(positive regulation of branching involved in ureteric bud morphogenesis)|go:"GO:0090259"(regulation of retinal ganglion cell axon guidance)|go:"GO:0097475"(motor neuron migration)|go:"GO:0097533"(cellular stress response to acid chemical)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1900086"(positive regulation of peptidyl-tyrosine autophosphorylation)|go:"GO:1900745"(positive regulation of p38MAPK cascade)|go:"GO:1901165"(positive regulation of trophoblast cell migration)|go:"GO:1901727"(positive regulation of histone deacetylase activity)|go:"GO:1902336"(positive regulation of retinal ganglion cell axon guidance)|go:"GO:1902966"(positive regulation of protein localization to early endosome)|go:"GO:1903141"(negative regulation of establishment of endothelial barrier)|go:"GO:0090037"(positive regulation of protein kinase C signaling)|rcsb pdb:1FLT|rcsb pdb:1KAT|rcsb pdb:1KMX|rcsb pdb:1MJV|rcsb pdb:1MKG|rcsb pdb:1MKK|rcsb pdb:1QTY|rcsb pdb:1TZH|rcsb pdb:1TZI|rcsb pdb:1VGH|rcsb pdb:1VPF|rcsb pdb:1VPP|rcsb pdb:2FJG|rcsb pdb:2FJH|rcsb pdb:2QR0|rcsb pdb:2VGH|rcsb pdb:2VPF|rcsb pdb:3BDY|rcsb pdb:3P9W|rcsb pdb:3QTK|rcsb pdb:3S1B|rcsb pdb:3S1K|rcsb pdb:3V2A|rcsb pdb:4DEQ|rcsb pdb:4GLN|rcsb pdb:4GLS|rcsb pdb:4KZN|rcsb pdb:4QAF|rcsb pdb:4WPB|rcsb pdb:4ZFF|rcsb pdb:5DN2|rcsb pdb:5FV1|rcsb pdb:5FV2|rcsb pdb:5HHC|rcsb pdb:5HHD|rcsb pdb:5O4E|rcsb pdb:1CZ8|rcsb pdb:5T89|rcsb pdb:6BFT|rcsb pdb:6D3O|rcsb pdb:6T9D|rcsb pdb:6V7K|rcsb pdb:6Z13|rcsb pdb:6Z3F|rcsb pdb:6ZBR|rcsb pdb:6ZCD|rcsb pdb:6ZFL|rcsb pdb:7LL9|reactome:R-HSA-114608|reactome:R-HSA-1234158|reactome:R-HSA-194138|reactome:R-HSA-194313|reactome:R-HSA-195399|reactome:R-HSA-4420097|reactome:R-HSA-5218921|reactome:R-HSA-6785807|reactome:R-HSA-8866910|reactome:R-HSA-9679191|rcsb pdb:7LL8|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043117"(positive regulation of vascular permeability)|go:"GO:0043129"(surfactant homeostasis)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043183"(vascular endothelial growth factor receptor 1 binding)|go:"GO:0043184"(vascular endothelial growth factor receptor 2 binding)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0042462"(eye photoreceptor cell development)|refseq:NP_001273973.1|dip:DIP-5740N	-	comment:"sVEGFR1fc (P17948) used in this experiment is a commercial one from RELIATech GmbH. It has an extra aminoacid (Arg) between  Thr751 and Ser752"	-	figure legend:Fig.1C|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/01/13	2014/10/16	rogid:AfSO/WFuXISaK/PbB/s2Vv+vLFE9606	rogid:O5iw4Qx7W34QAg3oFkltpRxDYwA9606	intact-crc:417343C0ABE72BC9|rigid:lbP4Q3nZ8wMqBST1qfcw7vwtfqU	false	fc-igg tag:?-?|sufficient binding region:27-756	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P17948	uniprotkb:P49763	intact:EBI-1026718|uniprotkb:B0LPF1|uniprotkb:B3FR89|uniprotkb:B5A923|uniprotkb:O60722|uniprotkb:P16057|uniprotkb:Q12954|uniprotkb:A8KA71|ensembl:ENSP00000282397|uniprotkb:A3E342|uniprotkb:A3E344|uniprotkb:B2BF46|uniprotkb:B2BF47|uniprotkb:F5H5L6|uniprotkb:B2BF48	intact:EBI-1037633|uniprotkb:Q07101|uniprotkb:Q9BV78|uniprotkb:Q9Y6S8|ensembl:ENSP00000385365	psi-mi:vgfr1_human(display_long)|uniprotkb:Vascular permeability factor receptor(gene name synonym)|uniprotkb:Tyrosine-protein kinase receptor FLT(gene name synonym)|uniprotkb:Tyrosine-protein kinase FRT(gene name synonym)|uniprotkb:Fms-like tyrosine kinase 1(gene name synonym)|uniprotkb:FLT1(gene name)|psi-mi:FLT1(display_short)|uniprotkb:FLT(gene name synonym)|uniprotkb:FRT(gene name synonym)|uniprotkb:VEGFR1(gene name synonym)	psi-mi:plgf_human(display_long)|uniprotkb:PGF(gene name)|psi-mi:PGF(display_short)|uniprotkb:PLGF(gene name synonym)|uniprotkb:PGFL(gene name synonym)	psi-mi:"MI:0411"(enzyme linked immunosorbent assay)	Mitola et al. (2010)	pubmed:20660291|imex:IM-22165	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-9098469|imex:IM-22165-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0941"(competitor)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001153392.1|refseq:NP_002010.2|ensembl:ENSG00000102755(gene)|ensembl:ENST00000282397(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005021"(vascular endothelial growth factor-activated receptor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005768"(endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010863"(positive regulation of phospholipase C activity)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016477"(cell migration)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019838"(growth factor binding)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|go:"GO:0036323"(vascular endothelial growth factor receptor-1 signaling pathway)|go:"GO:0036332"(placental growth factor-activated receptor activity)|go:"GO:0002244"(hematopoietic progenitor cell differentiation)|go:"GO:0043235"(receptor complex)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|go:"GO:0048514"(blood vessel morphogenesis)|go:"GO:0048598"(embryonic morphogenesis)|go:"GO:1905563"(negative regulation of vascular endothelial cell proliferation)|go:"GO:1990384"(hyaloid vascular plexus regression)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001824(Receptor tyrosine kinase, class III, conserved site)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR009135(Vascular endothelial growth factor receptor 1, VEGFR1, N-terminal)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR036179|mint:P17948|rcsb pdb:1FLT|rcsb pdb:1QSV|rcsb pdb:1QSZ|rcsb pdb:1QTY|rcsb pdb:1RV6|rcsb pdb:2XAC|rcsb pdb:3HNG|rcsb pdb:4CKV|rcsb pdb:4CL7|rcsb pdb:5ABD|rcsb pdb:5EX3|rcsb pdb:5T89|reactome:R-HSA-194306|reactome:R-HSA-195399|interpro:IPR041348|refseq:NP_001153502.1|refseq:NP_001153503.1|dip:DIP-643N	refseq:NP_001193941.1|refseq:NP_002623.2|ensembl:ENSG00000119630(gene)|ensembl:ENST00000405431(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0005172"(vascular endothelial growth factor receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0007165"(signal transduction)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007565"(female pregnancy)|go:"GO:0008083"(growth factor activity)|go:"GO:0008201"(heparin binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0030154"(cell differentiation)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0032870"(cellular response to hormone stimulus)|go:"GO:0038084"(vascular endothelial growth factor signaling pathway)|go:"GO:0042056"(chemoattractant activity)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|go:"GO:0050930"(induction of positive chemotaxis)|go:"GO:0051781"(positive regulation of cell division)|go:"GO:0060754"(positive regulation of mast cell chemotaxis)|interpro:IPR000072("Platelet-derived growth factor (PDGF)")|interpro:IPR023581|interpro:IPR029034|rcsb pdb:1FZV|rcsb pdb:1RV6|reactome:R-HSA-194313|reactome:R-HSA-195399|go:"GO:0002040"(sprouting angiogenesis)|dip:DIP-5752N	-	comment:"sVEGFR1fc (P17948) used in this experiment is a commercial one from RELIATech GmbH. It has an extra aminoacid (Arg) between  Thr751 and Ser752"	-	figure legend:Fig.1C|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/01/13	2014/10/16	rogid:AfSO/WFuXISaK/PbB/s2Vv+vLFE9606	rogid:ZzP1Vm13H9Z88uewZGydsqbLths9606	intact-crc:417343C0ABE72BC9|rigid:lbP4Q3nZ8wMqBST1qfcw7vwtfqU	false	fc-igg tag:?-?|sufficient binding region:27-756	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O60565	uniprotkb:P35968	intact:EBI-944395|uniprotkb:Q52LV3|uniprotkb:Q8N914|uniprotkb:Q8N936|ensembl:ENSP00000300177|ensembl:ENSP00000498605|ensembl:ENSP00000498748|ensembl:ENSP00000498763|ensembl:ENSP00000498897	intact:EBI-1005487|intact:EBI-28976571|ensembl:ENSP00000263923|uniprotkb:O60723|uniprotkb:Q14178|uniprotkb:A2RRS0|uniprotkb:B5A925|uniprotkb:C5IFA0	psi-mi:grem1_human(display_long)|uniprotkb:GREM1(gene name)|psi-mi:GREM1(display_short)|uniprotkb:CKTSF1B1(gene name synonym)|uniprotkb:DAND2(gene name synonym)|uniprotkb:DRM(gene name synonym)|uniprotkb:PIG2(orf name)|uniprotkb:Cysteine knot superfamily 1, BMP antagonist 1(gene name synonym)|uniprotkb:Increased in high glucose protein 2(gene name synonym)|uniprotkb:Down-regulated in Mos-transformed cells protein(gene name synonym)|uniprotkb:DAN domain family member 2(gene name synonym)|uniprotkb:Cell proliferation-inducing gene 2 protein(gene name synonym)	psi-mi:vgfr2_human(display_long)|uniprotkb:Kinase insert domain receptor(gene name synonym)|uniprotkb:Protein-tyrosine kinase receptor flk-1(gene name synonym)|uniprotkb:KDR(gene name)|psi-mi:KDR(display_short)|uniprotkb:FLK1(gene name synonym)|uniprotkb:Fetal liver kinase 1(gene name synonym)|uniprotkb:VEGFR2(gene name synonym)	psi-mi:"MI:0030"(cross-linking study)	Mitola et al. (2010)	pubmed:20660291|imex:IM-22165	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-9084770|imex:IM-22165-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001178252.1|refseq:NP_037504.1|go:"GO:0090190"(positive regulation of branching involved in ureteric bud morphogenesis)|go:"GO:0090291"(negative regulation of osteoclast proliferation)|go:"GO:1900086"(positive regulation of peptidyl-tyrosine autophosphorylation)|go:"GO:1900155"(negative regulation of bone trabecula formation)|go:"GO:1900158"(negative regulation of bone mineralization involved in bone maturation)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:2000273"(positive regulation of signaling receptor activity)|go:"GO:2000727"(positive regulation of cardiac muscle cell differentiation)|interpro:IPR004133(DAN)|interpro:IPR006207(Cystine knot, C-terminal)|interpro:IPR017159(Gremlin precursor)|interpro:IPR029034|rcsb pdb:5AEJ|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|ensembl:ENSG00000166923(gene)|ensembl:ENSG00000276886(gene)|ensembl:ENSG00000282046(gene)|ensembl:ENST00000300177(transcript)|ensembl:ENST00000651081(transcript)|ensembl:ENST00000651154(transcript)|ensembl:ENST00000651986(transcript)|ensembl:ENST00000652365(transcript)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0002042"(cell migration involved in sprouting angiogenesis)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0003257"(positive regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation)|go:"GO:0003337"(mesenchymal to epithelial transition involved in metanephros morphogenesis)|go:"GO:0005125"(cytokine activity)|go:"GO:0005615"(extracellular space)|go:"GO:0006915"(apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0009954"(proximal/distal pattern formation)|go:"GO:0009986"(cell surface)|go:"GO:0010717"(regulation of epithelial to mesenchymal transition)|go:"GO:0016015"(morphogen activity)|go:"GO:0030199"(collagen fibril organization)|go:"GO:0030297"(transmembrane receptor protein tyrosine kinase activator activity)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030326"(embryonic limb morphogenesis)|go:"GO:0030502"(negative regulation of bone mineralization)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0032331"(negative regulation of chondrocyte differentiation)|go:"GO:0033689"(negative regulation of osteoblast proliferation)|go:"GO:0036122"(BMP binding)|go:"GO:0038098"(sequestering of BMP from receptor via BMP binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043184"(vascular endothelial growth factor receptor 2 binding)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046851"(negative regulation of bone remodeling)|go:"GO:0048018"(receptor ligand activity)|go:"GO:0048263"(determination of dorsal identity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051893"(regulation of focal adhesion assembly)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0060173"(limb development)|go:"GO:0060394"(negative regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0060676"(ureteric bud formation)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0090027"(negative regulation of monocyte chemotaxis)	refseq:NP_002244.1|ensembl:ENSP00000263923|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0016477"(cell migration)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019838"(growth factor binding)|go:"GO:0030054"(cell junction)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0035162"(embryonic hemopoiesis)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|go:"GO:0036324"(vascular endothelial growth factor receptor-2 signaling pathway)|go:"GO:0038033"(positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway)|go:"GO:0038083"(peptidyl-tyrosine autophosphorylation)|go:"GO:0038084"(vascular endothelial growth factor signaling pathway)|go:"GO:0038085"(vascular endothelial growth factor binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043235"(receptor complex)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0045121"(membrane raft)|go:"GO:0045296"(cadherin binding)|go:"GO:0045446"(endothelial cell differentiation)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|go:"GO:0050927"(positive regulation of positive chemotaxis)|go:"GO:0051770"(positive regulation of nitric-oxide synthase biosynthetic process)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0051901"(positive regulation of mitochondrial depolarization)|go:"GO:0061042"(vascular wound healing)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0090141"(positive regulation of mitochondrial fission)|go:"GO:0097443"(sorting endosome)|go:"GO:1904881"(cellular response to hydrogen sulfide)|go:"GO:2000352"(negative regulation of endothelial cell apoptotic process)|go:"GO:2001214"(positive regulation of vasculogenesis)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001824(Receptor tyrosine kinase, class III, conserved site)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR009136(Vascular endothelial growth factor receptor 2, VEGFR2)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR036179|interpro:IPR041348|go:"GO:0090050"(positive regulation of cell migration involved in sprouting angiogenesis)|mint:P35968|rcsb pdb:1VR2|rcsb pdb:1Y6A|rcsb pdb:1Y6B|rcsb pdb:1YWN|rcsb pdb:2M59|rcsb pdb:2MET|rcsb pdb:2MEU|rcsb pdb:2OH4|rcsb pdb:2P2H|rcsb pdb:2P2I|rcsb pdb:2QU5|rcsb pdb:2QU6|rcsb pdb:2RL5|rcsb pdb:2X1W|rcsb pdb:2X1X|rcsb pdb:2XIR|rcsb pdb:3B8Q|rcsb pdb:3B8R|rcsb pdb:3BE2|rcsb pdb:3C7Q|rcsb pdb:3CJF|rcsb pdb:3CJG|rcsb pdb:3CP9|rcsb pdb:3CPB|rcsb pdb:3CPC|rcsb pdb:3DTW|rcsb pdb:3EFL|rcsb pdb:3EWH|rcsb pdb:3KVQ|rcsb pdb:3S35|rcsb pdb:3S36|rcsb pdb:3S37|rcsb pdb:3U6J|rcsb pdb:3V2A|rcsb pdb:3V6B|rcsb pdb:3VHE|rcsb pdb:3VHK|rcsb pdb:3VID|rcsb pdb:3VNT|rcsb pdb:3VO3|rcsb pdb:3WZD|rcsb pdb:3WZE|rcsb pdb:4AG8|rcsb pdb:4AGC|rcsb pdb:4AGD|rcsb pdb:4ASD|rcsb pdb:4ASE|rcsb pdb:5EW3|rcsb pdb:5OYJ|rcsb pdb:6GQO|rcsb pdb:6GQP|rcsb pdb:6GQQ|rcsb pdb:6XVJ|rcsb pdb:6XVK|reactome:R-HSA-194306|reactome:R-HSA-195399|reactome:R-HSA-216083|reactome:R-HSA-4420097|reactome:R-HSA-5218921|reactome:R-HSA-9673768|ensembl:ENSG00000128052(gene)|ensembl:ENST00000263923(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001569"(branching involved in blood vessel morphogenesis)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0002042"(cell migration involved in sprouting angiogenesis)|go:"GO:0002244"(hematopoietic progenitor cell differentiation)|go:"GO:0003158"(endothelium development)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005021"(vascular endothelial growth factor-activated receptor activity)|go:"GO:0005178"(integrin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|dip:DIP-486N	-	-	-	figure legend:fig.1D|comment:"The VEGFR2 biotinylation by sulfo-gremlin was inhibited by an excess of unlabeled gremlin ( O60565) or VEGF-A (P15692) that were acting as antagonists."|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-uvec)|taxid:9606("Human Umbilical Vein Endothelial Cells (HUVEC)")	-	2014/01/13	2016/03/07	rogid:eo1SLD8rZOBrQBcawMffMRz4Ex09606	rogid:NnrnIZM28U6DGKYiDT9+sh/fi8Y9606	intact-crc:74806BCA5E65E583|rigid:EFgx7c0YcWNOqlrSiDvl/DZ77EI	false	biotin tag:?-?	-	-	-	psi-mi:"MI:0981"(tag visualisation by peroxidase activity)	psi-mi:"MI:0981"(tag visualisation by peroxidase activity)