#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P61006	uniprotkb:Q96CV9	intact:EBI-722293|intact:EBI-1054454|uniprotkb:P24407|intact:EBI-2798283|uniprotkb:Q6FHV5|uniprotkb:B4DEK7|ensembl:ENSP00000300935	intact:EBI-748974|uniprotkb:Q5T672|uniprotkb:Q5T673|uniprotkb:Q5T674|uniprotkb:Q5T675|uniprotkb:Q7LDL9|uniprotkb:Q8N562|uniprotkb:Q9UET9|uniprotkb:Q9UEV4|uniprotkb:Q9Y218|uniprotkb:B3KP00|uniprotkb:D3DRS4|uniprotkb:D3DRS8|ensembl:ENSP00000263036|ensembl:ENSP00000368021|ensembl:ENSP00000368022|ensembl:ENSP00000368032	psi-mi:rab8a_human(display_long)|uniprotkb:Oncogene c-mel(gene name synonym)|uniprotkb:RAB8A(gene name)|psi-mi:RAB8A(display_short)|uniprotkb:MEL(gene name synonym)|uniprotkb:RAB8(gene name synonym)	psi-mi:optn_human(display_long)|uniprotkb:HYPL(gene name synonym)|uniprotkb:Optic neuropathy-inducing protein(gene name synonym)|uniprotkb:E3-14.7K-interacting protein(gene name synonym)|uniprotkb:FIP-2(gene name synonym)|uniprotkb:Huntingtin-interacting protein L(gene name synonym)|uniprotkb:Huntingtin yeast partner L(gene name synonym)|uniprotkb:NEMO-related protein(gene name synonym)|uniprotkb:Transcription factor IIIA-interacting protein(gene name synonym)|uniprotkb:OPTN(gene name)|psi-mi:OPTN(display_short)|uniprotkb:FIP2(gene name synonym)|uniprotkb:GLC1E(gene name synonym)|uniprotkb:NRP(gene name synonym)|uniprotkb:HIP7(gene name synonym)|uniprotkb:Huntingtin-interacting protein 7(gene name synonym)	psi-mi:"MI:0809"(bimolecular fluorescence complementation)	Chi et al. (2010)	imex:IM-23024|pubmed:20388642	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-9664102|imex:IM-23024-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005361.2|dip:DIP-43703N|ensembl:ENSG00000167461(gene)|ensembl:ENST00000300935(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005768"(endosome)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005929"(cilium)|go:"GO:0006904"(vesicle docking involved in exocytosis)|go:"GO:0006914"(autophagy)|go:"GO:0007409"(axonogenesis)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0009306"(protein secretion)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0019003"(GDP binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030496"(midbody)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031489"(myosin V binding)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048210"(Golgi vesicle fusion to target membrane)|go:"GO:0051223"(regulation of protein transport)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0060271"(cilium assembly)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0097730"(non-motile cilium)|go:"GO:0098887"(neurotransmitter receptor transport, endosome to postsynaptic membrane)|go:"GO:0098969"(neurotransmitter receptor transport to postsynaptic membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099003"(vesicle-mediated transport in synapse)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|mint:P61006|rcsb pdb:3QBT|rcsb pdb:3TNF|rcsb pdb:4LHV|rcsb pdb:4LHW|rcsb pdb:4LHX|rcsb pdb:4LHY|go:"GO:0014069"(postsynaptic density)|go:"GO:0017157"(regulation of exocytosis)|rcsb pdb:4LHZ|rcsb pdb:4LI0|rcsb pdb:5SZI|rcsb pdb:6RIR|rcsb pdb:6SQ2|rcsb pdb:6STF|rcsb pdb:6STG|rcsb pdb:6WHE|rcsb pdb:6ZSI|rcsb pdb:6ZSJ|rcsb pdb:7BWT|rcsb pdb:7LWB|reactome:R-HSA-1445148|reactome:R-HSA-2565942|reactome:R-HSA-5620912|reactome:R-HSA-5620916|reactome:R-HSA-8854214|reactome:R-HSA-8873719|reactome:R-HSA-8876198	refseq:NP_001008212.1|refseq:NP_001008213.1|refseq:NP_001008214.1|refseq:NP_068815.2|ensembl:ENSG00000123240(gene)|ensembl:ENST00000263036(transcript)|ensembl:ENST00000378747(transcript)|ensembl:ENST00000378748(transcript)|ensembl:ENST00000378757(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001920"(negative regulation of receptor recycling)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005776"(autophagosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0006914"(autophagy)|go:"GO:0007030"(Golgi organization)|go:"GO:0007165"(signal transduction)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008219"(cell death)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031267"(small GTPase binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043001"(Golgi to plasma membrane protein transport)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045087"(innate immune response)|go:"GO:0046872"(metal ion binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0031593"(polyubiquitin modification-dependent protein binding)|go:"GO:0034067"(protein localization to Golgi apparatus)|go:"GO:0034620"(cellular response to unfolded protein)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0061734"(parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization)|go:"GO:0070530"(K63-linked polyubiquitin modification-dependent protein binding)|go:"GO:0090161"(Golgi ribbon formation)|go:"GO:1904417"(positive regulation of xenophagy)|interpro:IPR021063|interpro:IPR032419|interpro:IPR032939|interpro:IPR034735|mint:Q96CV9|rcsb pdb:2LO4|rcsb pdb:2LUE|rcsb pdb:3VTV|rcsb pdb:3VTW|rcsb pdb:5AAZ|rcsb pdb:5B83|rcsb pdb:5EOA|rcsb pdb:5EOF|rcsb pdb:7CZM|reactome:R-HSA-2565942|reactome:R-HSA-8854214|dip:DIP-42001N	omim:137760(see-also)	-	-	figure legend:6B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat-rgc5)|taxid:10116(Rattus norvegicus)	-	2014/07/17	2018/04/06	rogid:ucWVK9e1z44F2XnAJatPYm8IRlk9606	rogid:jcCTXDx1bJq3K5mgNUD73jeWeBU9606	intact-crc:BD6A72765CBB6D98|rigid:kubdsvSXhuv4ySJ7+baZLwayrhc	false	kusabira-green protein tag:?-?|mutation:67-67|mutation decreasing interaction:22-22	mutation disrupting interaction:50-50|kusabira-green protein tag:?-?	-	-	psi-mi:"MI:0867"(tag visualisation by fluorescence)	psi-mi:"MI:0867"(tag visualisation by fluorescence)
uniprotkb:Q96CV9	uniprotkb:P61006	intact:EBI-748974|uniprotkb:Q5T672|uniprotkb:Q5T673|uniprotkb:Q5T674|uniprotkb:Q5T675|uniprotkb:Q7LDL9|uniprotkb:Q8N562|uniprotkb:Q9UET9|uniprotkb:Q9UEV4|uniprotkb:Q9Y218|uniprotkb:B3KP00|uniprotkb:D3DRS4|uniprotkb:D3DRS8|ensembl:ENSP00000263036|ensembl:ENSP00000368021|ensembl:ENSP00000368022|ensembl:ENSP00000368032	intact:EBI-722293|intact:EBI-1054454|uniprotkb:P24407|intact:EBI-2798283|uniprotkb:Q6FHV5|uniprotkb:B4DEK7|ensembl:ENSP00000300935	psi-mi:optn_human(display_long)|uniprotkb:HYPL(gene name synonym)|uniprotkb:Optic neuropathy-inducing protein(gene name synonym)|uniprotkb:E3-14.7K-interacting protein(gene name synonym)|uniprotkb:FIP-2(gene name synonym)|uniprotkb:Huntingtin-interacting protein L(gene name synonym)|uniprotkb:Huntingtin yeast partner L(gene name synonym)|uniprotkb:NEMO-related protein(gene name synonym)|uniprotkb:Transcription factor IIIA-interacting protein(gene name synonym)|uniprotkb:OPTN(gene name)|psi-mi:OPTN(display_short)|uniprotkb:FIP2(gene name synonym)|uniprotkb:GLC1E(gene name synonym)|uniprotkb:NRP(gene name synonym)|uniprotkb:HIP7(gene name synonym)|uniprotkb:Huntingtin-interacting protein 7(gene name synonym)	psi-mi:rab8a_human(display_long)|uniprotkb:Oncogene c-mel(gene name synonym)|uniprotkb:RAB8A(gene name)|psi-mi:RAB8A(display_short)|uniprotkb:MEL(gene name synonym)|uniprotkb:RAB8(gene name synonym)	psi-mi:"MI:0663"(confocal microscopy)	Chi et al. (2010)	imex:IM-23024|pubmed:20388642	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-9672327|imex:IM-23024-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001008212.1|refseq:NP_001008213.1|refseq:NP_001008214.1|refseq:NP_068815.2|ensembl:ENSG00000123240(gene)|ensembl:ENST00000263036(transcript)|ensembl:ENST00000378747(transcript)|ensembl:ENST00000378748(transcript)|ensembl:ENST00000378757(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001920"(negative regulation of receptor recycling)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005776"(autophagosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0006914"(autophagy)|go:"GO:0007030"(Golgi organization)|go:"GO:0007165"(signal transduction)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008219"(cell death)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031267"(small GTPase binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043001"(Golgi to plasma membrane protein transport)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045087"(innate immune response)|go:"GO:0046872"(metal ion binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0031593"(polyubiquitin modification-dependent protein binding)|go:"GO:0034067"(protein localization to Golgi apparatus)|go:"GO:0034620"(cellular response to unfolded protein)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0061734"(parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization)|go:"GO:0070530"(K63-linked polyubiquitin modification-dependent protein binding)|go:"GO:0090161"(Golgi ribbon formation)|go:"GO:1904417"(positive regulation of xenophagy)|interpro:IPR021063|interpro:IPR032419|interpro:IPR032939|interpro:IPR034735|mint:Q96CV9|rcsb pdb:2LO4|rcsb pdb:2LUE|rcsb pdb:3VTV|rcsb pdb:3VTW|rcsb pdb:5AAZ|rcsb pdb:5B83|rcsb pdb:5EOA|rcsb pdb:5EOF|rcsb pdb:7CZM|reactome:R-HSA-2565942|reactome:R-HSA-8854214|dip:DIP-42001N	refseq:NP_005361.2|dip:DIP-43703N|ensembl:ENSG00000167461(gene)|ensembl:ENST00000300935(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005768"(endosome)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005929"(cilium)|go:"GO:0006904"(vesicle docking involved in exocytosis)|go:"GO:0006914"(autophagy)|go:"GO:0007409"(axonogenesis)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0009306"(protein secretion)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0019003"(GDP binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030496"(midbody)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031489"(myosin V binding)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048210"(Golgi vesicle fusion to target membrane)|go:"GO:0051223"(regulation of protein transport)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0060271"(cilium assembly)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0097730"(non-motile cilium)|go:"GO:0098887"(neurotransmitter receptor transport, endosome to postsynaptic membrane)|go:"GO:0098969"(neurotransmitter receptor transport to postsynaptic membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099003"(vesicle-mediated transport in synapse)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|mint:P61006|rcsb pdb:3QBT|rcsb pdb:3TNF|rcsb pdb:4LHV|rcsb pdb:4LHW|rcsb pdb:4LHX|rcsb pdb:4LHY|go:"GO:0014069"(postsynaptic density)|go:"GO:0017157"(regulation of exocytosis)|rcsb pdb:4LHZ|rcsb pdb:4LI0|rcsb pdb:5SZI|rcsb pdb:6RIR|rcsb pdb:6SQ2|rcsb pdb:6STF|rcsb pdb:6STG|rcsb pdb:6WHE|rcsb pdb:6ZSI|rcsb pdb:6ZSJ|rcsb pdb:7BWT|rcsb pdb:7LWB|reactome:R-HSA-1445148|reactome:R-HSA-2565942|reactome:R-HSA-5620912|reactome:R-HSA-5620916|reactome:R-HSA-8854214|reactome:R-HSA-8873719|reactome:R-HSA-8876198	omim:137760(see-also)|go:"GO:0005794"(Golgi apparatus)	-	-	figure legend:6C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9534(chlae-cos_1)|taxid:9534(Chlorocebus aethiops COS-1 cells)	-	2014/07/17	2018/04/06	rogid:jcCTXDx1bJq3K5mgNUD73jeWeBU9606	rogid:ucWVK9e1z44F2XnAJatPYm8IRlk9606	intact-crc:8EC23F743AA17DDB|rigid:kubdsvSXhuv4ySJ7+baZLwayrhc	false	mutation disrupting interaction:50-50|kusabira-green protein tag:?-?	mutation:67-67|kusabira-green protein tag:?-?	-	-	psi-mi:"MI:0867"(tag visualisation by fluorescence)	psi-mi:"MI:0867"(tag visualisation by fluorescence)