#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P53299	uniprotkb:P57744	intact:EBI-9121|ensemblfungi:YGR181W|uniprotkb:D6VUW5	intact:EBI-9013892|uniprotkb:D6VWV4|ensemblfungi:YJR135W-A	psi-mi:tim13_yeast(display_long)|uniprotkb:G7157(orf name)|uniprotkb:YGR181W(locus name)|uniprotkb:TIM13(gene name)|psi-mi:TIM13(display_short)	psi-mi:tim8_yeast(display_long)|uniprotkb:TIM8(gene name)|psi-mi:TIM8(display_short)|uniprotkb:YJR135BW(orf name)|uniprotkb:YJR135W-A(locus name)	psi-mi:"MI:0808"(comigration in sds page)	Beverly et al. (2008)	pubmed:18706423|imex:IM-22012	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9206440|imex:IM-22012-6	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensemblfungi:YGR181W(gene)|ensemblfungi:YGR181W_mRNA(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0042719"(mitochondrial intermembrane space protein transporter complex)|go:"GO:0045039"(protein insertion into mitochondrial inner membrane)|go:"GO:0046872"(metal ion binding)|go:"GO:0140318"(protein transporter activity)|interpro:IPR004217(Zinc finger, Tim10/DDP-type)|interpro:IPR035427|interpro:IPR039238|rcsb pdb:3CJH|refseq:NP_011697.3|sgd:S000003413|dip:DIP-5547N|mint:P53299	refseq:NP_058168.1|sgd:S000007348|dip:DIP-8051N|ensemblfungi:YJR135W-A(gene)|ensemblfungi:YJR135W-A_mRNA(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0042719"(mitochondrial intermembrane space protein transporter complex)|go:"GO:0045039"(protein insertion into mitochondrial inner membrane)|go:"GO:0046872"(metal ion binding)|go:"GO:0140318"(protein transporter activity)|interpro:IPR004217(Zinc finger, Tim10/DDP-type)|interpro:IPR035427|interpro:IPR039238|rcsb pdb:3CJH	-	-	-	figure legend:Supp. Fig. 1A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/01/13	2014/10/16	rogid:VkM3K4RclcQUZwNCm3bPPlyY99Y559292	rogid:FgWLFDpvsn6Bip0SVw0KL3ll/VU559292	intact-crc:F2D9654AD4C5D709|rigid:BZN3nAM/N8+uU+d9GASab5Mx0Qg	false	-	his tag:c-c	-	-	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)
uniprotkb:P53299	uniprotkb:P57744	intact:EBI-9121|ensemblfungi:YGR181W|uniprotkb:D6VUW5	intact:EBI-9013892|uniprotkb:D6VWV4|ensemblfungi:YJR135W-A	psi-mi:tim13_yeast(display_long)|uniprotkb:G7157(orf name)|uniprotkb:YGR181W(locus name)|uniprotkb:TIM13(gene name)|psi-mi:TIM13(display_short)	psi-mi:tim8_yeast(display_long)|uniprotkb:TIM8(gene name)|psi-mi:TIM8(display_short)|uniprotkb:YJR135BW(orf name)|uniprotkb:YJR135W-A(locus name)	psi-mi:"MI:0114"(x-ray crystallography)	Beverly et al. (2008)	pubmed:18706423|imex:IM-22012	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9083698|wwpdb:3cjh|imex:IM-22012-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensemblfungi:YGR181W(gene)|ensemblfungi:YGR181W_mRNA(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0042719"(mitochondrial intermembrane space protein transporter complex)|go:"GO:0045039"(protein insertion into mitochondrial inner membrane)|go:"GO:0046872"(metal ion binding)|go:"GO:0140318"(protein transporter activity)|interpro:IPR004217(Zinc finger, Tim10/DDP-type)|interpro:IPR035427|interpro:IPR039238|rcsb pdb:3CJH|refseq:NP_011697.3|sgd:S000003413|dip:DIP-5547N|mint:P53299	refseq:NP_058168.1|sgd:S000007348|dip:DIP-8051N|ensemblfungi:YJR135W-A(gene)|ensemblfungi:YJR135W-A_mRNA(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0042719"(mitochondrial intermembrane space protein transporter complex)|go:"GO:0045039"(protein insertion into mitochondrial inner membrane)|go:"GO:0046872"(metal ion binding)|go:"GO:0140318"(protein transporter activity)|interpro:IPR004217(Zinc finger, Tim10/DDP-type)|interpro:IPR035427|interpro:IPR039238|rcsb pdb:3CJH	-	-	-	figure legend:Table 1|3d-r-factors:Rworking = 0.24 Rfree = 0.29|3d-resolution:2.6A|caution:"Sequence coordinates taken from the PDB submission file, however these do not correspond to the statement in the publication \"Several N-terminal and a few C-terminal residues were invisible in the electron density map due to disorder. These include Tim8 residues 1–27 and 87 and Tim13 residues 1–45 and 98–104.\" so it is possible that the constructs were full length."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/01/13	2014/10/16	rogid:VkM3K4RclcQUZwNCm3bPPlyY99Y559292	rogid:FgWLFDpvsn6Bip0SVw0KL3ll/VU559292	intact-crc:DF8A2E3F49D7C6A1|rigid:BZN3nAM/N8+uU+d9GASab5Mx0Qg	false	sufficient binding region:42-105	sufficient binding region:24-87	3	3	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P53299	uniprotkb:P57744	intact:EBI-9121|ensemblfungi:YGR181W|uniprotkb:D6VUW5	intact:EBI-9013892|uniprotkb:D6VWV4|ensemblfungi:YJR135W-A	psi-mi:tim13_yeast(display_long)|uniprotkb:G7157(orf name)|uniprotkb:YGR181W(locus name)|uniprotkb:TIM13(gene name)|psi-mi:TIM13(display_short)	psi-mi:tim8_yeast(display_long)|uniprotkb:TIM8(gene name)|psi-mi:TIM8(display_short)|uniprotkb:YJR135BW(orf name)|uniprotkb:YJR135W-A(locus name)	psi-mi:"MI:0016"(circular dichroism)	Beverly et al. (2008)	pubmed:18706423|imex:IM-22012	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9096766|imex:IM-22012-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensemblfungi:YGR181W(gene)|ensemblfungi:YGR181W_mRNA(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0042719"(mitochondrial intermembrane space protein transporter complex)|go:"GO:0045039"(protein insertion into mitochondrial inner membrane)|go:"GO:0046872"(metal ion binding)|go:"GO:0140318"(protein transporter activity)|interpro:IPR004217(Zinc finger, Tim10/DDP-type)|interpro:IPR035427|interpro:IPR039238|rcsb pdb:3CJH|refseq:NP_011697.3|sgd:S000003413|dip:DIP-5547N|mint:P53299	refseq:NP_058168.1|sgd:S000007348|dip:DIP-8051N|ensemblfungi:YJR135W-A(gene)|ensemblfungi:YJR135W-A_mRNA(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0042719"(mitochondrial intermembrane space protein transporter complex)|go:"GO:0045039"(protein insertion into mitochondrial inner membrane)|go:"GO:0046872"(metal ion binding)|go:"GO:0140318"(protein transporter activity)|interpro:IPR004217(Zinc finger, Tim10/DDP-type)|interpro:IPR035427|interpro:IPR039238|rcsb pdb:3CJH	-	-	-	figure legend:Fig. 2C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/01/13	2014/10/16	rogid:VkM3K4RclcQUZwNCm3bPPlyY99Y559292	rogid:FgWLFDpvsn6Bip0SVw0KL3ll/VU559292	intact-crc:CFDE8CBE7E90150C|rigid:BZN3nAM/N8+uU+d9GASab5Mx0Qg	false	-	his tag:c-c	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P53299	uniprotkb:P57744	intact:EBI-9121|ensemblfungi:YGR181W|uniprotkb:D6VUW5	intact:EBI-9013892|uniprotkb:D6VWV4|ensemblfungi:YJR135W-A	psi-mi:tim13_yeast(display_long)|uniprotkb:G7157(orf name)|uniprotkb:YGR181W(locus name)|uniprotkb:TIM13(gene name)|psi-mi:TIM13(display_short)	psi-mi:tim8_yeast(display_long)|uniprotkb:TIM8(gene name)|psi-mi:TIM8(display_short)|uniprotkb:YJR135BW(orf name)|uniprotkb:YJR135W-A(locus name)	psi-mi:"MI:0276"(blue native page)	Beverly et al. (2008)	pubmed:18706423|imex:IM-22012	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9096808|imex:IM-22012-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensemblfungi:YGR181W(gene)|ensemblfungi:YGR181W_mRNA(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0042719"(mitochondrial intermembrane space protein transporter complex)|go:"GO:0045039"(protein insertion into mitochondrial inner membrane)|go:"GO:0046872"(metal ion binding)|go:"GO:0140318"(protein transporter activity)|interpro:IPR004217(Zinc finger, Tim10/DDP-type)|interpro:IPR035427|interpro:IPR039238|rcsb pdb:3CJH|refseq:NP_011697.3|sgd:S000003413|dip:DIP-5547N|mint:P53299	refseq:NP_058168.1|sgd:S000007348|dip:DIP-8051N|ensemblfungi:YJR135W-A(gene)|ensemblfungi:YJR135W-A_mRNA(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0042719"(mitochondrial intermembrane space protein transporter complex)|go:"GO:0045039"(protein insertion into mitochondrial inner membrane)|go:"GO:0046872"(metal ion binding)|go:"GO:0140318"(protein transporter activity)|interpro:IPR004217(Zinc finger, Tim10/DDP-type)|interpro:IPR035427|interpro:IPR039238|rcsb pdb:3CJH	-	-	-	figure legend:Fig. 2E|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/01/13	2014/10/16	rogid:VkM3K4RclcQUZwNCm3bPPlyY99Y559292	rogid:FgWLFDpvsn6Bip0SVw0KL3ll/VU559292	intact-crc:7BE93C0B674C8C09|rigid:BZN3nAM/N8+uU+d9GASab5Mx0Qg	false	-	his tag:c-c	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0396"(predetermined participant)
wwpdb:3cjh	uniprotkb:P32897	intact:EBI-9013894	intact:EBI-9136|ensemblfungi:YNR017W|uniprotkb:D6W1J2	psi-mi:tim8-tim13_yeast(display_short)|psi-mi:3cjh(display_long)|intact:TIM8-TIM13 mitochondrial intermembrane space protein transporter complex(complex recommended name)|intact:"3xTIM8:3xTIM13"(complex systematic name)	psi-mi:tim23_yeast(display_long)|uniprotkb:MIM23(gene name synonym)|uniprotkb:MPI3(gene name synonym)|uniprotkb:N3180(orf name)|uniprotkb:YNR017W(locus name)|uniprotkb:TIM23(gene name)|psi-mi:TIM23(display_short)|uniprotkb:MAS6(gene name synonym)|uniprotkb:Mitochondrial protein import protein 3(gene name synonym)|uniprotkb:Mitochondrial protein import protein MAS6(gene name synonym)|uniprotkb:Membrane import machinery protein MIM23(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Beverly et al. (2008)	pubmed:18706423|imex:IM-22012	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9096975|imex:IM-22012-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:1302"(stable complex)	psi-mi:"MI:0326"(protein)	intact:EBI-9083698(exp-evidence)|go:"GO:0045039"(protein insertion into mitochondrial inner membrane)|go:"GO:0042719"(mitochondrial intermembrane space protein transporter complex)|go:"GO:0005739"(mitochondrion)|complex portal:CPX-2371(complex-primary)|go:"GO:0005758"(mitochondrial intermembrane space)|evidence ontology:"ECO:0000353"	reactome:R-SCE-1268020|ensemblfungi:YNR017W(gene)|ensemblfungi:YNR017W_mRNA(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005744"(TIM23 mitochondrial import inner membrane translocase complex)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0008320"(protein transmembrane transporter activity)|go:"GO:0030150"(protein import into mitochondrial matrix)|go:"GO:0030943"(mitochondrion targeting sequence binding)|go:"GO:0031305"(integral component of mitochondrial inner membrane)|interpro:IPR005681(Mitochondrial import inner membrane translocase, subunit Tim23)|refseq:NP_014414.3|sgd:S000005300|dip:DIP-2451N|mint:P32897	-	curated-complex:"Facilitates transport of hydrophobic precursors of a distinct subgroup of inner membrane proteins through the aqueous intermembrane space as they exit the TOM40 channel complex (CPX-474) in the outer membrane. Plays a role in the import of a distinct subgroup of inner membrane proteins, functioning as a chaperone to maintain the hydrophobic membrane proteins in an import competent state and escort substrates to the TIM22 insertion complex (CPX-1629), which mediates protein insertion into the membrane. Cross-links to the COOH-terminal domain of the essential import translocase protein TIM23 (P32897) and plays a key role in TIM23 import to the mitochondrial inner membrane."|complex-properties:Each subunit contains a central loop flanked by disulfide bonds that separate two extended N- and C-terminal helices. Buried salt-bridges between highly conserved lysine and glutamate residues connect alternating subunits.    Mol. wt. = 70kDa.|complex-assembly:Heterohexamer	crc64:08E5AB4F400F675B	figure legend:Figs. 5 and 6|comment:The addition of pep91– 103 with pep136–148 increased the binding of pep136–148 approximately three times above that of pep136–148 alone. This positive cooperativity implies that binding at one site on the complex may influence binding at other sites.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/01/13	2016/06/28	-	rogid:nA6mnSq0Ek0I5g8LSJpLjojiRvc559292	intact-crc:D3C799C78114D874	false	-	sufficient binding region:91-103|sufficient binding region:77-88	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P53299	uniprotkb:P32897	intact:EBI-9121|ensemblfungi:YGR181W|uniprotkb:D6VUW5	intact:EBI-9136|ensemblfungi:YNR017W|uniprotkb:D6W1J2	psi-mi:tim13_yeast(display_long)|uniprotkb:G7157(orf name)|uniprotkb:YGR181W(locus name)|uniprotkb:TIM13(gene name)|psi-mi:TIM13(display_short)	psi-mi:tim23_yeast(display_long)|uniprotkb:MIM23(gene name synonym)|uniprotkb:MPI3(gene name synonym)|uniprotkb:N3180(orf name)|uniprotkb:YNR017W(locus name)|uniprotkb:TIM23(gene name)|psi-mi:TIM23(display_short)|uniprotkb:MAS6(gene name synonym)|uniprotkb:Mitochondrial protein import protein 3(gene name synonym)|uniprotkb:Mitochondrial protein import protein MAS6(gene name synonym)|uniprotkb:Membrane import machinery protein MIM23(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Beverly et al. (2008)	pubmed:18706423|imex:IM-22012	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9096952|imex:IM-22012-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensemblfungi:YGR181W(gene)|ensemblfungi:YGR181W_mRNA(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0042719"(mitochondrial intermembrane space protein transporter complex)|go:"GO:0045039"(protein insertion into mitochondrial inner membrane)|go:"GO:0046872"(metal ion binding)|go:"GO:0140318"(protein transporter activity)|interpro:IPR004217(Zinc finger, Tim10/DDP-type)|interpro:IPR035427|interpro:IPR039238|rcsb pdb:3CJH|refseq:NP_011697.3|sgd:S000003413|dip:DIP-5547N|mint:P53299	reactome:R-SCE-1268020|ensemblfungi:YNR017W(gene)|ensemblfungi:YNR017W_mRNA(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005744"(TIM23 mitochondrial import inner membrane translocase complex)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0008320"(protein transmembrane transporter activity)|go:"GO:0030150"(protein import into mitochondrial matrix)|go:"GO:0030943"(mitochondrion targeting sequence binding)|go:"GO:0031305"(integral component of mitochondrial inner membrane)|interpro:IPR005681(Mitochondrial import inner membrane translocase, subunit Tim23)|refseq:NP_014414.3|sgd:S000005300|dip:DIP-2451N|mint:P32897	-	-	crc64:08E5AB4F400F675B	figure legend:Fig. 3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:6.13x10^-4(molar)	2014/01/13	2014/10/16	rogid:VkM3K4RclcQUZwNCm3bPPlyY99Y559292	rogid:nA6mnSq0Ek0I5g8LSJpLjojiRvc559292	intact-crc:F881D013AF6D9A26|rigid:u6LMKVmWhjNuOlcodnT1TnKlQJU	false	his tag:c-c	sufficient binding region:91-103	1	1	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P32897	wwpdb:3cjh	intact:EBI-9136|ensemblfungi:YNR017W|uniprotkb:D6W1J2	intact:EBI-9013894	psi-mi:tim23_yeast(display_long)|uniprotkb:MIM23(gene name synonym)|uniprotkb:MPI3(gene name synonym)|uniprotkb:N3180(orf name)|uniprotkb:YNR017W(locus name)|uniprotkb:TIM23(gene name)|psi-mi:TIM23(display_short)|uniprotkb:MAS6(gene name synonym)|uniprotkb:Mitochondrial protein import protein 3(gene name synonym)|uniprotkb:Mitochondrial protein import protein MAS6(gene name synonym)|uniprotkb:Membrane import machinery protein MIM23(gene name synonym)	psi-mi:tim8-tim13_yeast(display_short)|psi-mi:3cjh(display_long)|intact:TIM8-TIM13 mitochondrial intermembrane space protein transporter complex(complex recommended name)|intact:"3xTIM8:3xTIM13"(complex systematic name)	psi-mi:"MI:0107"(surface plasmon resonance)	Beverly et al. (2008)	pubmed:18706423|imex:IM-22012	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9096964|imex:IM-22012-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:1302"(stable complex)	reactome:R-SCE-1268020|ensemblfungi:YNR017W(gene)|ensemblfungi:YNR017W_mRNA(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005744"(TIM23 mitochondrial import inner membrane translocase complex)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0008320"(protein transmembrane transporter activity)|go:"GO:0030150"(protein import into mitochondrial matrix)|go:"GO:0030943"(mitochondrion targeting sequence binding)|go:"GO:0031305"(integral component of mitochondrial inner membrane)|interpro:IPR005681(Mitochondrial import inner membrane translocase, subunit Tim23)|refseq:NP_014414.3|sgd:S000005300|dip:DIP-2451N|mint:P32897	intact:EBI-9083698(exp-evidence)|go:"GO:0045039"(protein insertion into mitochondrial inner membrane)|go:"GO:0042719"(mitochondrial intermembrane space protein transporter complex)|go:"GO:0005739"(mitochondrion)|complex portal:CPX-2371(complex-primary)|go:"GO:0005758"(mitochondrial intermembrane space)|evidence ontology:"ECO:0000353"	-	crc64:08E5AB4F400F675B	curated-complex:"Facilitates transport of hydrophobic precursors of a distinct subgroup of inner membrane proteins through the aqueous intermembrane space as they exit the TOM40 channel complex (CPX-474) in the outer membrane. Plays a role in the import of a distinct subgroup of inner membrane proteins, functioning as a chaperone to maintain the hydrophobic membrane proteins in an import competent state and escort substrates to the TIM22 insertion complex (CPX-1629), which mediates protein insertion into the membrane. Cross-links to the COOH-terminal domain of the essential import translocase protein TIM23 (P32897) and plays a key role in TIM23 import to the mitochondrial inner membrane."|complex-properties:Each subunit contains a central loop flanked by disulfide bonds that separate two extended N- and C-terminal helices. Buried salt-bridges between highly conserved lysine and glutamate residues connect alternating subunits.    Mol. wt. = 70kDa.|complex-assembly:Heterohexamer	figure legend:Fig. 4, 5a, Supp. Fig. 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:3.5x10^-4(molar)	2014/01/13	2016/06/28	rogid:nA6mnSq0Ek0I5g8LSJpLjojiRvc559292	-	intact-crc:38ADF0EE38DBDA07	false	sufficient binding region:91-103	his tag:?-?	6	1	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)