#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P25605	uniprotkb:P07342	intact:EBI-9087|uniprotkb:P87009|ensemblfungi:YCL009C|uniprotkb:D6VR03	intact:EBI-9096|ensemblfungi:YMR108W|uniprotkb:D6VZT1	psi-mi:ilv6_yeast(display_long)|uniprotkb:ILV6(gene name)|psi-mi:ILV6(display_short)|uniprotkb:YCL009C(locus name)|uniprotkb:YCL9C(orf name)|uniprotkb:Acetohydroxy-acid synthase small subunit(gene name synonym)	psi-mi:ilvb_yeast(display_long)|uniprotkb:ILV2(gene name)|psi-mi:ILV2(display_short)|uniprotkb:SMR1(gene name synonym)|uniprotkb:YMR108W(locus name)|uniprotkb:YM9718.07(orf name)|uniprotkb:Acetohydroxy-acid synthase catalytic subunit(gene name synonym)	psi-mi:"MI:0415"(enzymatic study)	Lee et al. (2006)	imex:IM-22514|pubmed:16390333	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0414"(enzymatic reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9301798|imex:IM-22514-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensemblfungi:YCL009C(gene)|ensemblfungi:YCL009C_mRNA(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005948"(acetolactate synthase complex)|go:"GO:0009082"(branched-chain amino acid biosynthetic process)|go:"GO:0009097"(isoleucine biosynthetic process)|go:"GO:0009099"(valine biosynthetic process)|go:"GO:0030234"(enzyme regulator activity)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:1990610"(acetolactate synthase regulator activity)|interpro:IPR002912(Amino acid-binding ACT)|interpro:IPR004789(Acetolactate synthase, small subunit)|interpro:IPR019455|interpro:IPR039557|rcsb pdb:6U9D|rcsb pdb:6WO1|refseq:NP_009918.1|sgd:S000000515|dip:DIP-671N|mint:P25605	ensemblfungi:YMR108W(gene)|ensemblfungi:YMR108W_mRNA(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0003984"(acetolactate synthase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005948"(acetolactate synthase complex)|go:"GO:0009082"(branched-chain amino acid biosynthetic process)|go:"GO:0009097"(isoleucine biosynthetic process)|go:"GO:0009099"(valine biosynthetic process)|go:"GO:0030976"(thiamine pyrophosphate binding)|go:"GO:0050660"(flavin adenine dinucleotide binding)|interpro:IPR000399(TPP-binding enzymes, conserved site)|interpro:IPR011766(Thiamine pyrophosphate enzyme, C-terminal TPP-binding)|interpro:IPR012000(Thiamine pyrophosphate enzyme, central region)|interpro:IPR012001(Thiamine pyrophosphate enzyme, N-terminal TPP binding region)|interpro:IPR012846(Acetolactate synthase, large subunit, biosynthetic)|interpro:IPR029035|interpro:IPR029061|interpro:IPR039368|rcsb pdb:1JSC|rcsb pdb:1N0H|rcsb pdb:1T9A|rcsb pdb:1T9B|rcsb pdb:1T9C|rcsb pdb:1T9D|rcsb pdb:5FEM|rcsb pdb:5IMS|rcsb pdb:5WKC|rcsb pdb:6BD3|rcsb pdb:6BD9|rcsb pdb:6U9D|refseq:NP_013826.1|sgd:S000004714|mint:P07342|dip:DIP-1104N	-	-	crc64:B03C4D0F38AA1362	comment:His205Ala, Arg216ala, Lys218Ala, His219Ala and Leu222Ala abolish MgATP activation of the enzyme and probably constitute the binding site for this regulatory ligand.Ilv6 mutated at  Leu177Aala, Phe204Ala, Pro206Ala and Ser212Ala only weakly stimulate the catalystic subunit but each of them is strongly activated by MgATP. The resulting enzyme is then inhibited by valine.|figure legend:Figs. 2-4, Table 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/03/24	2014/10/16	rogid:agwmYb1U/j/ymO/tmbf7ac4QM98559292	rogid:9A0deezeL4n1dExQk1cgdggICGs559292	intact-crc:CE8D6D9FEDE3D991	false	his tag:n-n|mutation decreasing interaction rate:218-218|mutation decreasing interaction rate:219-219|sufficient binding region:41-309|mutation decreasing interaction rate:216-216|mutation decreasing interaction rate:205-205	his tag:n-n|sufficient binding region:55-687	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
chebi:"CHEBI:15361"	uniprotkb:P25605	intact:EBI-6621808	intact:EBI-9087|uniprotkb:P87009|ensemblfungi:YCL009C|uniprotkb:D6VR03	psi-mi:pyruvate(display_short)|psi-mi:"CHEBI:15361"(display_long)	psi-mi:ilv6_yeast(display_long)|uniprotkb:ILV6(gene name)|psi-mi:ILV6(display_short)|uniprotkb:YCL009C(locus name)|uniprotkb:YCL9C(orf name)|uniprotkb:Acetohydroxy-acid synthase small subunit(gene name synonym)	psi-mi:"MI:0415"(enzymatic study)	Lee et al. (2006)	imex:IM-22514|pubmed:16390333	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0414"(enzymatic reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9301798|imex:IM-22514-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensemblfungi:YCL009C(gene)|ensemblfungi:YCL009C_mRNA(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005948"(acetolactate synthase complex)|go:"GO:0009082"(branched-chain amino acid biosynthetic process)|go:"GO:0009097"(isoleucine biosynthetic process)|go:"GO:0009099"(valine biosynthetic process)|go:"GO:0030234"(enzyme regulator activity)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:1990610"(acetolactate synthase regulator activity)|interpro:IPR002912(Amino acid-binding ACT)|interpro:IPR004789(Acetolactate synthase, small subunit)|interpro:IPR019455|interpro:IPR039557|rcsb pdb:6U9D|rcsb pdb:6WO1|refseq:NP_009918.1|sgd:S000000515|dip:DIP-671N|mint:P25605	-	-	-	comment:His205Ala, Arg216ala, Lys218Ala, His219Ala and Leu222Ala abolish MgATP activation of the enzyme and probably constitute the binding site for this regulatory ligand.Ilv6 mutated at  Leu177Aala, Phe204Ala, Pro206Ala and Ser212Ala only weakly stimulate the catalystic subunit but each of them is strongly activated by MgATP. The resulting enzyme is then inhibited by valine.|figure legend:Figs. 2-4, Table 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/03/24	2014/10/16	-	rogid:agwmYb1U/j/ymO/tmbf7ac4QM98559292	intact-crc:CE8D6D9FEDE3D991	false	-	his tag:n-n|mutation decreasing interaction rate:218-218|mutation decreasing interaction rate:219-219|sufficient binding region:41-309|mutation decreasing interaction rate:216-216|mutation decreasing interaction rate:205-205	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)