#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:P0C045 uniprotkb:Q63HM2 intact:EBI-9351969 intact:EBI-1104540|uniprotkb:Q9BQG8|uniprotkb:Q9H9F2|uniprotkb:A8MXM2|ensembl:ENSP00000384801 psi-mi:f_hcv77(display_long)|uniprotkb:Alternate reading frame protein/F-protein(gene name synonym)|uniprotkb:Frameshifted protein(gene name synonym)|uniprotkb:p16(gene name synonym)|uniprotkb:p17(gene name synonym) psi-mi:pcx4_human(display_long)|uniprotkb:PCNX4(gene name)|psi-mi:PCNX4(display_short)|uniprotkb:C14orf135(gene name synonym)|uniprotkb:FBP2(gene name synonym)|uniprotkb:Hepatitis C virus F protein-binding protein 2(gene name synonym)|uniprotkb:PCNXL4(gene name synonym)|uniprotkb:Pecanex homolog protein 4(gene name synonym) psi-mi:"MI:0018"(two hybrid) Huang et al. (2005) imex:IM-23791|pubmed:16237761 taxid:63746(HCV77)|taxid:63746("Hepatitis C virus genotype 1a (isolate H77)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:1335"(HPIDb) intact:EBI-10685725|imex:IM-23791-14 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR002522(Hepatitis C virus capsid protein)|go:"GO:0001848"(complement binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0019028"(viral capsid)|go:"GO:0019899"(enzyme binding)|go:"GO:0031267"(small GTPase binding)|go:"GO:0035375"(zymogen binding)|go:"GO:0039540"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of host RIG-I activity)|go:"GO:0042025"(host cell nucleus)|go:"GO:0044220"(host cell perinuclear region of cytoplasm)|go:"GO:0051494"(negative regulation of cytoskeleton organization)|go:"GO:0097655"(serpin family protein binding) ensembl:ENSG00000126773(gene)|ensembl:ENST00000406854(transcript)|go:"GO:0016021"(integral component of membrane)|interpro:IPR007735(Pecanex)|interpro:IPR039797|refseq:NP_071940.4|refseq:NP_001317106.1 - - - figure legend:Table 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2014/04/04 2015/02/26 rogid:UBoCmCg80GlVxpcs3q93gqjcUGk63746 rogid:rf5CFSLdXxG+w6Uyr6+pbvD090E9606 intact-crc:55E8005D86AE2DBB|rigid:tVdxh2Cw7Zidc3GUhNaaRlboLXs false - - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P0C045 uniprotkb:P05156 intact:EBI-9351969 intact:EBI-9352022|uniprotkb:O60442|ensembl:ENSP00000378130 psi-mi:f_hcv77(display_long)|uniprotkb:Alternate reading frame protein/F-protein(gene name synonym)|uniprotkb:Frameshifted protein(gene name synonym)|uniprotkb:p16(gene name synonym)|uniprotkb:p17(gene name synonym) psi-mi:cfai_human(display_long)|uniprotkb:CFI(gene name)|psi-mi:CFI(display_short)|uniprotkb:IF(gene name synonym)|uniprotkb:C3B/C4B inactivator(gene name synonym) psi-mi:"MI:0018"(two hybrid) Huang et al. (2005) imex:IM-23791|pubmed:16237761 taxid:63746(HCV77)|taxid:63746("Hepatitis C virus genotype 1a (isolate H77)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:1335"(HPIDb) intact:EBI-9352054|imex:IM-23791-12 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR002522(Hepatitis C virus capsid protein)|go:"GO:0001848"(complement binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0019028"(viral capsid)|go:"GO:0019899"(enzyme binding)|go:"GO:0031267"(small GTPase binding)|go:"GO:0035375"(zymogen binding)|go:"GO:0039540"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of host RIG-I activity)|go:"GO:0042025"(host cell nucleus)|go:"GO:0044220"(host cell perinuclear region of cytoplasm)|go:"GO:0051494"(negative regulation of cytoskeleton organization)|go:"GO:0097655"(serpin family protein binding) refseq:NP_001317964.1|refseq:NP_000195.2|ensembl:ENSG00000205403(gene)|ensembl:ENST00000394634(transcript)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005044"(scavenger receptor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006958"(complement activation, classical pathway)|go:"GO:0016020"(membrane)|go:"GO:0045087"(innate immune response)|go:"GO:0046872"(metal ion binding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001190(Speract/scavenger receptor)|interpro:IPR001254(Peptidase S1 and S6, chymotrypsin/Hap)|interpro:IPR001314(Peptidase S1A, chymotrypsin)|interpro:IPR002172(Low density lipoprotein-receptor, class A, cysteine-rich)|interpro:IPR002350(Proteinase inhibitor I1, Kazal)|interpro:IPR003884(Factor I membrane attack complex)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR017448(Speract/scavenger receptor related)|interpro:IPR018114|interpro:IPR023415|interpro:IPR033116|interpro:IPR036055|interpro:IPR036058|interpro:IPR036772|interpro:IPR043504|mint:P05156|rcsb pdb:2XRC|rcsb pdb:5O32|reactome:R-HSA-977606 - - - figure legend:Table 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2014/04/04 2015/02/26 rogid:UBoCmCg80GlVxpcs3q93gqjcUGk63746 rogid:2zm8YwMWNSX3vv6fLIJ3WZ6hrLc9606 intact-crc:A836730B3B2EF996|rigid:wmaGVpnbuCYisqGrA2C1IryVNtE false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:P0C045 uniprotkb:O60844 intact:EBI-9351969 intact:EBI-746479|uniprotkb:B2R4Z3|uniprotkb:B9EK72|ensembl:ENSP00000383563 psi-mi:f_hcv77(display_long)|uniprotkb:Alternate reading frame protein/F-protein(gene name synonym)|uniprotkb:Frameshifted protein(gene name synonym)|uniprotkb:p16(gene name synonym)|uniprotkb:p17(gene name synonym) psi-mi:zg16_human(display_long)|uniprotkb:Secretory lectin ZG16(gene name synonym)|uniprotkb:ZG16(gene name)|psi-mi:ZG16(display_short) psi-mi:"MI:0018"(two hybrid) Huang et al. (2005) imex:IM-23791|pubmed:16237761 taxid:63746(HCV77)|taxid:63746("Hepatitis C virus genotype 1a (isolate H77)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:1335"(HPIDb) intact:EBI-9352018|imex:IM-23791-11 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR002522(Hepatitis C virus capsid protein)|go:"GO:0001848"(complement binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0019028"(viral capsid)|go:"GO:0019899"(enzyme binding)|go:"GO:0031267"(small GTPase binding)|go:"GO:0035375"(zymogen binding)|go:"GO:0039540"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of host RIG-I activity)|go:"GO:0042025"(host cell nucleus)|go:"GO:0044220"(host cell perinuclear region of cytoplasm)|go:"GO:0051494"(negative regulation of cytoskeleton organization)|go:"GO:0097655"(serpin family protein binding) refseq:NP_689551.2|interpro:IPR036404|rcsb pdb:3APA|rcsb pdb:3VY6|rcsb pdb:3VY7|rcsb pdb:3VZE|rcsb pdb:3VZF|rcsb pdb:3VZG|rcsb pdb:7O3I|rcsb pdb:7O4P|rcsb pdb:7O88|interpro:IPR033563|ensembl:ENSG00000174992(gene)|ensembl:ENST00000400752(transcript)|go:"GO:0005615"(extracellular space)|go:"GO:0005796"(Golgi lumen)|go:"GO:0015031"(protein transport)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0042589"(zymogen granule membrane)|go:"GO:0042834"(peptidoglycan binding)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0052373"(suppression of symbiont entry into host)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070701"(mucus layer)|interpro:IPR001229(Mannose-binding lectin) - - - figure legend:Table 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2014/04/04 2015/02/26 rogid:UBoCmCg80GlVxpcs3q93gqjcUGk63746 rogid:yvT25LlIDWHOuxDA2l+yYCpuBWY9606 intact-crc:EC14560D3F135A4E|rigid:YUqvP8cv6zFQhpyoLDP+EHPL+dQ false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:P05155 uniprotkb:P0C045 intact:EBI-1223454|uniprotkb:Q547W3|uniprotkb:Q59EI5|uniprotkb:Q96FE0|uniprotkb:A6NMU0|uniprotkb:A8KAI9|uniprotkb:B2R6L5|uniprotkb:Q16304|uniprotkb:Q7Z455|uniprotkb:Q9UC49|uniprotkb:Q9UCF9|uniprotkb:B4E1F0|uniprotkb:B4E1H2|ensembl:ENSP00000278407|ensembl:ENSP00000504807 intact:EBI-9351969 psi-mi:ic1_human(display_long)|uniprotkb:SERPING1(gene name)|psi-mi:SERPING1(display_short)|uniprotkb:C1IN(gene name synonym)|uniprotkb:C1NH(gene name synonym)|uniprotkb:C1 esterase inhibitor(gene name synonym)|uniprotkb:C1-inhibiting factor(gene name synonym)|uniprotkb:Serpin G1(gene name synonym) psi-mi:f_hcv77(display_long)|uniprotkb:Alternate reading frame protein/F-protein(gene name synonym)|uniprotkb:Frameshifted protein(gene name synonym)|uniprotkb:p16(gene name synonym)|uniprotkb:p17(gene name synonym) psi-mi:"MI:0018"(two hybrid) Huang et al. (2005) imex:IM-23791|pubmed:16237761 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:63746(HCV77)|taxid:63746("Hepatitis C virus genotype 1a (isolate H77)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:1335"(HPIDb) intact:EBI-9352014|imex:IM-23791-10 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_000053.2|refseq:NP_001027466.1|dip:DIP-45635N|ensembl:ENSG00000149131(gene)|ensembl:ENST00000278407(transcript)|ensembl:ENST00000676670(transcript)|go:"GO:0001869"(negative regulation of complement activation, lectin pathway)|go:"GO:0004867"(serine-type endopeptidase inhibitor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0006958"(complement activation, classical pathway)|go:"GO:0007568"(aging)|go:"GO:0007596"(blood coagulation)|go:"GO:0008015"(blood circulation)|go:"GO:0010951"(negative regulation of endopeptidase activity)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0042730"(fibrinolysis)|go:"GO:0045087"(innate immune response)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|interpro:IPR000215(Protease inhibitor I4, serpin)|interpro:IPR015553(Protease inhibitor I4, serpin C1)|interpro:IPR023795|interpro:IPR023796|interpro:IPR036186|interpro:IPR042178|interpro:IPR042185|mint:P05155|rcsb pdb:1M6Q|rcsb pdb:2OAY|rcsb pdb:5DU3|rcsb pdb:5DUQ|rcsb pdb:7AKV|reactome:R-HSA-114608|reactome:R-HSA-140837|reactome:R-HSA-9657689|reactome:R-HSA-977606 interpro:IPR002522(Hepatitis C virus capsid protein)|go:"GO:0001848"(complement binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0019028"(viral capsid)|go:"GO:0019899"(enzyme binding)|go:"GO:0031267"(small GTPase binding)|go:"GO:0035375"(zymogen binding)|go:"GO:0039540"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of host RIG-I activity)|go:"GO:0042025"(host cell nucleus)|go:"GO:0044220"(host cell perinuclear region of cytoplasm)|go:"GO:0051494"(negative regulation of cytoskeleton organization)|go:"GO:0097655"(serpin family protein binding) - - - figure legend:Table 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2014/04/04 2015/02/26 rogid:Y7cqCZ6Ryz51dsi6jM86EXdfeWc9606 rogid:UBoCmCg80GlVxpcs3q93gqjcUGk63746 intact-crc:FD88241E4A5A03E5|rigid:S5jaNpoEKRI4lEnrg7Mby1xoD6g false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:P0C045 uniprotkb:P04004 intact:EBI-9351969 intact:EBI-1036653|uniprotkb:P01141|uniprotkb:Q9BSH7|uniprotkb:B2R7G0|ensembl:ENSP00000226218 psi-mi:f_hcv77(display_long)|uniprotkb:Alternate reading frame protein/F-protein(gene name synonym)|uniprotkb:Frameshifted protein(gene name synonym)|uniprotkb:p16(gene name synonym)|uniprotkb:p17(gene name synonym) psi-mi:vtnc_human(display_long)|uniprotkb:VTN(gene name)|psi-mi:VTN(display_short)|uniprotkb:Serum-spreading factor(gene name synonym)|uniprotkb:V75(gene name synonym)|uniprotkb:S-protein(gene name synonym) psi-mi:"MI:0018"(two hybrid) Huang et al. (2005) imex:IM-23791|pubmed:16237761 taxid:63746(HCV77)|taxid:63746("Hepatitis C virus genotype 1a (isolate H77)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:1335"(HPIDb) intact:EBI-9352010|imex:IM-23791-9 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR002522(Hepatitis C virus capsid protein)|go:"GO:0001848"(complement binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0019028"(viral capsid)|go:"GO:0019899"(enzyme binding)|go:"GO:0031267"(small GTPase binding)|go:"GO:0035375"(zymogen binding)|go:"GO:0039540"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of host RIG-I activity)|go:"GO:0042025"(host cell nucleus)|go:"GO:0044220"(host cell perinuclear region of cytoplasm)|go:"GO:0051494"(negative regulation of cytoskeleton organization)|go:"GO:0097655"(serpin family protein binding) refseq:NP_000629.3|ensembl:ENSG00000109072(gene)|ensembl:ENST00000226218(transcript)|go:"GO:0005044"(scavenger receptor activity)|go:"GO:0005178"(integrin binding)|go:"GO:0005201"(extracellular matrix structural constituent)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0006955"(immune response)|go:"GO:0007155"(cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0008201"(heparin binding)|go:"GO:0010951"(negative regulation of endopeptidase activity)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016477"(cell migration)|go:"GO:0030195"(negative regulation of blood coagulation)|go:"GO:0030247"(polysaccharide binding)|go:"GO:0030949"(positive regulation of vascular endothelial growth factor receptor signaling pathway)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0033627"(cell adhesion mediated by integrin)|go:"GO:0035987"(endodermal cell differentiation)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0048260"(positive regulation of receptor-mediated endocytosis)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0061302"(smooth muscle cell-matrix adhesion)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071062"(alphav-beta3 integrin-vitronectin complex)|go:"GO:0072562"(blood microparticle)|go:"GO:0090303"(positive regulation of wound healing)|interpro:IPR000585(Hemopexin)|interpro:IPR001212(Somatomedin B)|interpro:IPR018486|interpro:IPR018487|interpro:IPR020436|interpro:IPR036024|interpro:IPR036375|mint:P04004|rcsb pdb:1OC0|rcsb pdb:1S4G|rcsb pdb:1SSU|rcsb pdb:2JQ8|rcsb pdb:3BT1|rcsb pdb:3BT2|rcsb pdb:4K24|rcsb pdb:6O5E|reactome:R-HSA-2129379|reactome:R-HSA-216083|reactome:R-HSA-3000170|reactome:R-HSA-3000178|reactome:R-HSA-977606|dip:DIP-36566N - - - figure legend:Table 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2014/04/04 2015/02/26 rogid:UBoCmCg80GlVxpcs3q93gqjcUGk63746 rogid:07qxfQS6kbUZGwPyNj8/LTetT6I9606 intact-crc:D5C0C9FD022414C6|rigid:rHaaMAWfyqS3ReAx2tuEhR3LWAw false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:P0C045 uniprotkb:P07858 intact:EBI-9351969 intact:EBI-715062|uniprotkb:Q503A6|uniprotkb:Q96D87|uniprotkb:B3KRR5|uniprotkb:B3KQR5|ensembl:ENSP00000503300|ensembl:ENSP00000503435|ensembl:ENSP00000503487|ensembl:ENSP00000503513|ensembl:ENSP00000503578|ensembl:ENSP00000503608|ensembl:ENSP00000503652|ensembl:ENSP00000503674|ensembl:ENSP00000503858|ensembl:ENSP00000503909|ensembl:ENSP00000504161|ensembl:ENSP00000504226|ensembl:ENSP00000504336|ensembl:ENSP00000504480|ensembl:ENSP00000504638|ensembl:ENSP00000504659|ensembl:ENSP00000504797|ensembl:ENSP00000503280|ensembl:ENSP00000342070|ensembl:ENSP00000345672|ensembl:ENSP00000431143|ensembl:ENSP00000431518|ensembl:ENSP00000432077|ensembl:ENSP00000432244|ensembl:ENSP00000432408|ensembl:ENSP00000433215|ensembl:ENSP00000433379|ensembl:ENSP00000433929|ensembl:ENSP00000434217|ensembl:ENSP00000434725|ensembl:ENSP00000435074|ensembl:ENSP00000435105|ensembl:ENSP00000435260|ensembl:ENSP00000435886|ensembl:ENSP00000473301|ensembl:ENSP00000502963|ensembl:ENSP00000503006|ensembl:ENSP00000503052|ensembl:ENSP00000503078|ensembl:ENSP00000503174 psi-mi:f_hcv77(display_long)|uniprotkb:Alternate reading frame protein/F-protein(gene name synonym)|uniprotkb:Frameshifted protein(gene name synonym)|uniprotkb:p16(gene name synonym)|uniprotkb:p17(gene name synonym) psi-mi:catb_human(display_long)|uniprotkb:Cathepsin B1(gene name synonym)|uniprotkb:APP secretase(gene name synonym)|uniprotkb:CTSB(gene name)|psi-mi:CTSB(display_short)|uniprotkb:CPSB(gene name synonym) psi-mi:"MI:0018"(two hybrid) Huang et al. (2005) imex:IM-23791|pubmed:16237761 taxid:63746(HCV77)|taxid:63746("Hepatitis C virus genotype 1a (isolate H77)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:1335"(HPIDb) intact:EBI-9352006|imex:IM-23791-8 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR002522(Hepatitis C virus capsid protein)|go:"GO:0001848"(complement binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0019028"(viral capsid)|go:"GO:0019899"(enzyme binding)|go:"GO:0031267"(small GTPase binding)|go:"GO:0035375"(zymogen binding)|go:"GO:0039540"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of host RIG-I activity)|go:"GO:0042025"(host cell nucleus)|go:"GO:0044220"(host cell perinuclear region of cytoplasm)|go:"GO:0051494"(negative regulation of cytoskeleton organization)|go:"GO:0097655"(serpin family protein binding) refseq:NP_001899.1|refseq:NP_680090.1|refseq:NP_680091.1|refseq:NP_680092.1|refseq:NP_680093.1|refseq:XP_011542114.1|refseq:XP_016868586.1|refseq:XP_016868587.1|refseq:XP_016868588.1|refseq:XP_016868589.1|ensembl:ENST00000345125(transcript)|ensembl:ENST00000353047(transcript)|ensembl:ENST00000524654(transcript)|ensembl:ENST00000526481(transcript)|ensembl:ENST00000526645(transcript)|ensembl:ENST00000527215(transcript)|ensembl:ENST00000534382(transcript)|ensembl:ENST00000527243(transcript)|ensembl:ENST00000534510(transcript)|ensembl:ENST00000676691(transcript)|ensembl:ENST00000676755(transcript)|ensembl:ENST00000676825(transcript)|ensembl:ENST00000676843(transcript)|ensembl:ENST00000676952(transcript)|ensembl:ENST00000677082(transcript)|ensembl:ENST00000677366(transcript)|ensembl:ENST00000677415(transcript)|ensembl:ENST00000528965(transcript)|ensembl:ENST00000530296(transcript)|ensembl:ENST00000530640(transcript)|ensembl:ENST00000677418(transcript)|ensembl:ENST00000677544(transcript)|ensembl:ENST00000677650(transcript)|ensembl:ENST00000677671(transcript)|ensembl:ENST00000677819(transcript)|ensembl:ENST00000677873(transcript)|ensembl:ENST00000678092(transcript)|ensembl:ENST00000678145(transcript)|ensembl:ENST00000678242(transcript)|ensembl:ENST00000531089(transcript)|ensembl:ENST00000678357(transcript)|ensembl:ENST00000531502(transcript)|ensembl:ENST00000678615(transcript)|ensembl:ENST00000532392(transcript)|ensembl:ENST00000678929(transcript)|ensembl:ENST00000532656(transcript)|ensembl:ENST00000533455(transcript)|ensembl:ENST00000679051(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005622"(intracellular anatomical structure)|go:"GO:0005764"(lysosome)|go:"GO:0006508"(proteolysis)|go:"GO:0006590"(thyroid hormone generation)|go:"GO:0008233"(peptidase activity)|go:"GO:0008234"(cysteine-type peptidase activity)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030574"(collagen catabolic process)|go:"GO:0030855"(epithelial cell differentiation)|go:"GO:0036021"(endolysosome lumen)|go:"GO:0042470"(melanosome)|go:"GO:0042981"(regulation of apoptotic process)|ensembl:ENST00000679128(transcript)|go:"GO:0043394"(proteoglycan binding)|ensembl:ENST00000679140(transcript)|go:"GO:0046697"(decidualization)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0005518"(collagen binding)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050790"(regulation of catalytic activity)|go:"GO:0051603"(proteolysis involved in cellular protein catabolic process)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097067"(cellular response to thyroid hormone stimulus)|ensembl:ENSG00000164733(gene)|interpro:IPR000169(Peptidase, cysteine peptidase active site)|interpro:IPR000668(Peptidase C1A, papain C-terminal)|interpro:IPR012599(Peptidase C1A, propeptide)|interpro:IPR025660|interpro:IPR025661|interpro:IPR038765|mint:P07858|rcsb pdb:1CSB|rcsb pdb:1GMY|rcsb pdb:1HUC|rcsb pdb:1PBH|rcsb pdb:2IPP|rcsb pdb:2PBH|rcsb pdb:3AI8|rcsb pdb:3CBJ|rcsb pdb:3CBK|rcsb pdb:3K9M|rcsb pdb:3PBH|rcsb pdb:5MBL|rcsb pdb:5MBM|rcsb pdb:6AY2|reactome:R-HSA-1442490|reactome:R-HSA-1679131|reactome:R-HSA-2022090|reactome:R-HSA-2132295|reactome:R-HSA-6798695|go:"GO:1904813"(ficolin-1-rich granule lumen)|refseq:XP_006716307.1|refseq:XP_006716308.1|dip:DIP-42785N - - - figure legend:Table 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2014/04/04 2015/02/26 rogid:UBoCmCg80GlVxpcs3q93gqjcUGk63746 rogid:TdxD7Gf4BmlJcfUSULihf9W3sKQ9606 intact-crc:4414EF85D1AA0C16|rigid:P6jDva/6U11ZqqQbySUcTwhRnZo false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:Q63HM2 uniprotkb:P0C045 intact:EBI-1104540|uniprotkb:Q9BQG8|uniprotkb:Q9H9F2|uniprotkb:A8MXM2|ensembl:ENSP00000384801 intact:EBI-9351969 psi-mi:pcx4_human(display_long)|uniprotkb:PCNX4(gene name)|psi-mi:PCNX4(display_short)|uniprotkb:C14orf135(gene name synonym)|uniprotkb:FBP2(gene name synonym)|uniprotkb:Hepatitis C virus F protein-binding protein 2(gene name synonym)|uniprotkb:PCNXL4(gene name synonym)|uniprotkb:Pecanex homolog protein 4(gene name synonym) psi-mi:f_hcv77(display_long)|uniprotkb:Alternate reading frame protein/F-protein(gene name synonym)|uniprotkb:Frameshifted protein(gene name synonym)|uniprotkb:p16(gene name synonym)|uniprotkb:p17(gene name synonym) psi-mi:"MI:0018"(two hybrid) Huang et al. (2005) imex:IM-23791|pubmed:16237761 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:63746(HCV77)|taxid:63746("Hepatitis C virus genotype 1a (isolate H77)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:1335"(HPIDb) intact:EBI-9351967|imex:IM-23791-1 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000126773(gene)|ensembl:ENST00000406854(transcript)|go:"GO:0016021"(integral component of membrane)|interpro:IPR007735(Pecanex)|interpro:IPR039797|refseq:NP_071940.4|refseq:NP_001317106.1 interpro:IPR002522(Hepatitis C virus capsid protein)|go:"GO:0001848"(complement binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0019028"(viral capsid)|go:"GO:0019899"(enzyme binding)|go:"GO:0031267"(small GTPase binding)|go:"GO:0035375"(zymogen binding)|go:"GO:0039540"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of host RIG-I activity)|go:"GO:0042025"(host cell nucleus)|go:"GO:0044220"(host cell perinuclear region of cytoplasm)|go:"GO:0051494"(negative regulation of cytoskeleton organization)|go:"GO:0097655"(serpin family protein binding) - - - figure legend:Table 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2014/04/04 2015/02/26 rogid:rf5CFSLdXxG+w6Uyr6+pbvD090E9606 rogid:UBoCmCg80GlVxpcs3q93gqjcUGk63746 intact-crc:C87881E753B523D2|rigid:tVdxh2Cw7Zidc3GUhNaaRlboLXs false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:P01019 uniprotkb:P0C045 intact:EBI-751728|uniprotkb:Q16358|uniprotkb:Q16359|uniprotkb:Q96F91|ensembl:ENSP00000355627 intact:EBI-9351969 psi-mi:angt_human(display_long)|uniprotkb:Serpin A8(gene name synonym)|uniprotkb:AGT(gene name)|psi-mi:AGT(display_short)|uniprotkb:SERPINA8(gene name synonym) psi-mi:f_hcv77(display_long)|uniprotkb:Alternate reading frame protein/F-protein(gene name synonym)|uniprotkb:Frameshifted protein(gene name synonym)|uniprotkb:p16(gene name synonym)|uniprotkb:p17(gene name synonym) psi-mi:"MI:0018"(two hybrid) Huang et al. (2005) imex:IM-23791|pubmed:16237761 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:63746(HCV77)|taxid:63746("Hepatitis C virus genotype 1a (isolate H77)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:1335"(HPIDb) intact:EBI-9351994|imex:IM-23791-5 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_000020.1|dip:DIP-309N|ensembl:ENSG00000135744(gene)|ensembl:ENST00000366667(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001819"(positive regulation of cytokine production)|rcsb pdb:2JP8|rcsb pdb:2WXW|rcsb pdb:2X0B|rcsb pdb:3CK0|rcsb pdb:3WOO|rcsb pdb:3WOR|rcsb pdb:4AA1|rcsb pdb:4APH|rcsb pdb:4FYS|rcsb pdb:5E2Q|rcsb pdb:5M3X|rcsb pdb:5M3Y|rcsb pdb:5XJM|rcsb pdb:6I3F|rcsb pdb:6I3I|rcsb pdb:6JOD|rcsb pdb:6OS0|rcsb pdb:7C6A|reactome:R-HSA-1989781|reactome:R-HSA-2022377|reactome:R-HSA-375276|reactome:R-HSA-416476|reactome:R-HSA-418594|go:"GO:0001822"(kidney development)|go:"GO:0001974"(blood vessel remodeling)|go:"GO:0002016"(regulation of blood volume by renin-angiotensin)|go:"GO:0002018"(renin-angiotensin regulation of aldosterone production)|go:"GO:0002019"(regulation of renal output by angiotensin)|go:"GO:0002027"(regulation of heart rate)|go:"GO:0002034"(maintenance of blood vessel diameter homeostasis by renin-angiotensin)|go:"GO:0003014"(renal system process)|go:"GO:0003051"(angiotensin-mediated drinking behavior)|go:"GO:0003331"(positive regulation of extracellular matrix constituent secretion)|go:"GO:0004867"(serine-type endopeptidase inhibitor activity)|go:"GO:0005179"(hormone activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005829"(cytosol)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006883"(cellular sodium ion homeostasis)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007199"(G protein-coupled receptor signaling pathway coupled to cGMP nucleotide second messenger)|go:"GO:0007200"(phospholipase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0007202"(activation of phospholipase C activity)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007263"(nitric oxide mediated signal transduction)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007565"(female pregnancy)|go:"GO:0007568"(aging)|go:"GO:0008083"(growth factor activity)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042311"(vasodilation)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043407"(negative regulation of MAP kinase activity)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0045742"(positive regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0045777"(positive regulation of blood pressure)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046628"(positive regulation of insulin receptor signaling pathway)|go:"GO:0048018"(receptor ligand activity)|go:"GO:0048144"(fibroblast proliferation)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048659"(smooth muscle cell proliferation)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051387"(negative regulation of neurotrophin TRK receptor signaling pathway)|go:"GO:0051403"(stress-activated MAPK cascade)|go:"GO:0051924"(regulation of calcium ion transport)|go:"GO:0051969"(regulation of transmission of nerve impulse)|go:"GO:0061049"(cell growth involved in cardiac muscle cell development)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0070471"(uterine smooth muscle contraction)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0072562"(blood microparticle)|go:"GO:0090190"(positive regulation of branching involved in ureteric bud morphogenesis)|go:"GO:1901201"(regulation of extracellular matrix assembly)|go:"GO:1902632"(positive regulation of membrane hyperpolarization)|go:"GO:1903598"(positive regulation of gap junction assembly)|go:"GO:1903779"(regulation of cardiac conduction)|go:"GO:1904385"(cellular response to angiotensin)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1904754"(positive regulation of vascular associated smooth muscle cell migration)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0008306"(associative learning)|go:"GO:0010536"(positive regulation of activation of Janus kinase activity)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010613"(positive regulation of cardiac muscle hypertrophy)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010666"(positive regulation of cardiac muscle cell apoptotic process)|go:"GO:0010744"(positive regulation of macrophage derived foam cell differentiation)|go:"GO:0010873"(positive regulation of cholesterol esterification)|go:"GO:0010951"(negative regulation of endopeptidase activity)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014061"(regulation of norepinephrine secretion)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014824"(artery smooth muscle contraction)|go:"GO:0014873"(response to muscle activity involved in regulation of muscle adaptation)|go:"GO:0016176"(superoxide-generating NADPH oxidase activator activity)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0017080"(sodium channel regulator activity)|go:"GO:0019229"(regulation of vasoconstriction)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0031702"(type 1 angiotensin receptor binding)|go:"GO:0031703"(type 2 angiotensin receptor binding)|go:"GO:0032270"(positive regulation of cellular protein metabolic process)|go:"GO:0032355"(response to estradiol)|go:"GO:0032930"(positive regulation of superoxide anion generation)|go:"GO:0033864"("positive regulation of NAD(P)H oxidase activity")|go:"GO:0034104"(negative regulation of tissue remodeling)|go:"GO:0034374"(low-density lipoprotein particle remodeling)|go:"GO:0035106"(operant conditioning)|go:"GO:0035813"(regulation of renal sodium excretion)|go:"GO:0035815"(positive regulation of renal sodium excretion)|go:"GO:0038166"(angiotensin-activated signaling pathway)|go:"GO:0008217"(regulation of blood pressure)|go:"GO:1905010"(positive regulation of L-lysine import across plasma membrane)|go:"GO:1905589"(positive regulation of L-arginine import across plasma membrane)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|go:"GO:2000650"(negative regulation of sodium ion transmembrane transporter activity)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|interpro:IPR000215(Protease inhibitor I4, serpin)|interpro:IPR000227(Angiotensinogen)|interpro:IPR023795|interpro:IPR023796|interpro:IPR033834|interpro:IPR036186|interpro:IPR042178|interpro:IPR042185|mint:P01019|rcsb pdb:1N9U|rcsb pdb:1N9V interpro:IPR002522(Hepatitis C virus capsid protein)|go:"GO:0001848"(complement binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0019028"(viral capsid)|go:"GO:0019899"(enzyme binding)|go:"GO:0031267"(small GTPase binding)|go:"GO:0035375"(zymogen binding)|go:"GO:0039540"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of host RIG-I activity)|go:"GO:0042025"(host cell nucleus)|go:"GO:0044220"(host cell perinuclear region of cytoplasm)|go:"GO:0051494"(negative regulation of cytoskeleton organization)|go:"GO:0097655"(serpin family protein binding) - - - figure legend:Table 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2014/04/04 2015/02/26 rogid:tt2vGFrfLSJ+dIa11l402Vs/3S49606 rogid:UBoCmCg80GlVxpcs3q93gqjcUGk63746 intact-crc:672829E7D90DB8E0|rigid:onrxGYEBarwjycjxIo7W7qQV05E false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:P61106 uniprotkb:P0C045 intact:EBI-1056404|uniprotkb:P35287|uniprotkb:Q5JVD4|uniprotkb:Q6Q7K5|uniprotkb:Q969L0|uniprotkb:Q9UI11|uniprotkb:B3KR31|ensembl:ENSP00000362946 intact:EBI-9351969 psi-mi:rab14_human(display_long)|uniprotkb:RAB14(gene name)|psi-mi:RAB14(display_short) psi-mi:f_hcv77(display_long)|uniprotkb:Alternate reading frame protein/F-protein(gene name synonym)|uniprotkb:Frameshifted protein(gene name synonym)|uniprotkb:p16(gene name synonym)|uniprotkb:p17(gene name synonym) psi-mi:"MI:0018"(two hybrid) Huang et al. (2005) imex:IM-23791|pubmed:16237761 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:63746(HCV77)|taxid:63746("Hepatitis C virus genotype 1a (isolate H77)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:1335"(HPIDb) intact:EBI-9351990|imex:IM-23791-4 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_057406.2|ensembl:ENSG00000119396(gene)|ensembl:ENST00000373840(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005795"(Golgi stack)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006895"(Golgi to endosome transport)|go:"GO:0008543"(fibroblast growth factor receptor signaling pathway)|go:"GO:0012505"(endomembrane system)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0019003"(GDP binding)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0031489"(myosin V binding)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032456"(endocytic recycling)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0042175"(nuclear outer membrane-endoplasmic reticulum membrane network)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0045995"(regulation of embryonic development)|go:"GO:0046907"(intracellular transport)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0055037"(recycling endosome)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0090382"(phagosome maturation)|go:"GO:0090387"(phagolysosome assembly involved in apoptotic cell clearance)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|interpro:IPR030702|mint:P61106|rcsb pdb:1Z0F|rcsb pdb:4D0G|rcsb pdb:4DRZ|reactome:R-HSA-1445148|reactome:R-HSA-1660499|reactome:R-HSA-6798695|reactome:R-HSA-8873719|reactome:R-HSA-8876198|dip:DIP-42491N interpro:IPR002522(Hepatitis C virus capsid protein)|go:"GO:0001848"(complement binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0019028"(viral capsid)|go:"GO:0019899"(enzyme binding)|go:"GO:0031267"(small GTPase binding)|go:"GO:0035375"(zymogen binding)|go:"GO:0039540"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of host RIG-I activity)|go:"GO:0042025"(host cell nucleus)|go:"GO:0044220"(host cell perinuclear region of cytoplasm)|go:"GO:0051494"(negative regulation of cytoskeleton organization)|go:"GO:0097655"(serpin family protein binding) - - - figure legend:Table 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2014/04/04 2015/02/26 rogid:qFP8UXDCPt/RcLTWlZLaitH2LF49606 rogid:UBoCmCg80GlVxpcs3q93gqjcUGk63746 intact-crc:758467370809D0EB|rigid:N7+fL9tN5PjzTbDbt3AfBE9OV9E false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:P0C045 uniprotkb:P25311 intact:EBI-9351969 intact:EBI-2513837|ensembl:ENSP00000292401|uniprotkb:Q5XKQ4|uniprotkb:O60386|uniprotkb:Q8N4N0|uniprotkb:D6W5T8 psi-mi:f_hcv77(display_long)|uniprotkb:Alternate reading frame protein/F-protein(gene name synonym)|uniprotkb:Frameshifted protein(gene name synonym)|uniprotkb:p16(gene name synonym)|uniprotkb:p17(gene name synonym) psi-mi:za2g_human(display_long)|uniprotkb:AZGP1(gene name)|psi-mi:AZGP1(display_short)|uniprotkb:ZAG(gene name synonym)|uniprotkb:ZNGP1(gene name synonym) psi-mi:"MI:0018"(two hybrid) Huang et al. (2005) imex:IM-23791|pubmed:16237761 taxid:63746(HCV77)|taxid:63746("Hepatitis C virus genotype 1a (isolate H77)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:1335"(HPIDb) intact:EBI-9351982|imex:IM-23791-2 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR002522(Hepatitis C virus capsid protein)|go:"GO:0001848"(complement binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0019028"(viral capsid)|go:"GO:0019899"(enzyme binding)|go:"GO:0031267"(small GTPase binding)|go:"GO:0035375"(zymogen binding)|go:"GO:0039540"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of host RIG-I activity)|go:"GO:0042025"(host cell nucleus)|go:"GO:0044220"(host cell perinuclear region of cytoplasm)|go:"GO:0051494"(negative regulation of cytoskeleton organization)|go:"GO:0097655"(serpin family protein binding) ensembl:ENSG00000160862(gene)|ensembl:ENST00000292401(transcript)|go:"GO:0001580"(detection of chemical stimulus involved in sensory perception of bitter taste)|go:"GO:0001895"(retina homeostasis)|go:"GO:0002476"(antigen processing and presentation of endogenous peptide antigen via MHC class Ib)|go:"GO:0004540"(ribonuclease activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0007155"(cell adhesion)|go:"GO:0008285"(negative regulation of cell population proliferation)|interpro:IPR036179|interpro:IPR037055|mint:P25311|rcsb pdb:1T7V|rcsb pdb:1T7W|rcsb pdb:1T7X|rcsb pdb:1T7Y|rcsb pdb:1T7Z|rcsb pdb:1T80|rcsb pdb:1ZAG|rcsb pdb:3ES6|rcsb pdb:6R2U|reactome:R-HSA-5223345|go:"GO:0008320"(protein transmembrane transporter activity)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001039(MHC class I, alpha chain, alpha1 and alpha2)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR011161(MHC class I-like antigen recognition)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR013783(Immunoglobulin-like fold)|refseq:NP_001176.1 - - - figure legend:Table 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2014/04/04 2015/02/26 rogid:UBoCmCg80GlVxpcs3q93gqjcUGk63746 rogid:3Fp6qALNiZRqsI8Kh2lTQ9IMYek9606 intact-crc:370D8200FA89792B|rigid:7nY0J/uij6FIXNOhA7MPx67/dj0 false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:P0C045 uniprotkb:O75352 intact:EBI-9351969 intact:EBI-1046501|ensembl:ENSP00000250124|uniprotkb:B3KQP1|uniprotkb:Q9BUU8|uniprotkb:B4DT74 psi-mi:f_hcv77(display_long)|uniprotkb:Alternate reading frame protein/F-protein(gene name synonym)|uniprotkb:Frameshifted protein(gene name synonym)|uniprotkb:p16(gene name synonym)|uniprotkb:p17(gene name synonym) psi-mi:mpu1_human(display_long)|uniprotkb:Suppressor of Lec15 and Lec35 glycosylation mutation homolog(gene name synonym)|uniprotkb:MPDU1(gene name)|psi-mi:MPDU1(display_short) psi-mi:"MI:0018"(two hybrid) Huang et al. (2005) imex:IM-23791|pubmed:16237761 taxid:63746(HCV77)|taxid:63746("Hepatitis C virus genotype 1a (isolate H77)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:1335"(HPIDb) intact:EBI-9351986|imex:IM-23791-3 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR002522(Hepatitis C virus capsid protein)|go:"GO:0001848"(complement binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0019028"(viral capsid)|go:"GO:0019899"(enzyme binding)|go:"GO:0031267"(small GTPase binding)|go:"GO:0035375"(zymogen binding)|go:"GO:0039540"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of host RIG-I activity)|go:"GO:0042025"(host cell nucleus)|go:"GO:0044220"(host cell perinuclear region of cytoplasm)|go:"GO:0051494"(negative regulation of cytoskeleton organization)|go:"GO:0097655"(serpin family protein binding) ensembl:ENSG00000129255(gene)|ensembl:ENST00000250124(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006457"(protein folding)|go:"GO:0006488"(dolichol-linked oligosaccharide biosynthetic process)|go:"GO:0009312"(oligosaccharide biosynthetic process)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|interpro:IPR006603(Cystinosin/ERS1p repeat)|interpro:IPR016817(Mannose-P-dolichol utilization defect 1 protein)|reactome:R-HSA-446193|reactome:R-HSA-4687000|refseq:NP_004861.2|refseq:NP_001317002.1 - - - figure legend:Table 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2014/04/04 2015/02/26 rogid:UBoCmCg80GlVxpcs3q93gqjcUGk63746 rogid:fTQ9idHmko5H6UYo6izQewwjR7U9606 intact-crc:ECE9DAEAAFCA8788|rigid:xj/FGmp/Gjr76rMyVGgu3N4MPsE false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:P0C045 uniprotkb:P15907 intact:EBI-9351969 intact:EBI-2854700|uniprotkb:B2R513|uniprotkb:A8KA14|uniprotkb:D3DNV3|ensembl:ENSP00000169298|ensembl:ENSP00000389337|ensembl:ENSP00000414504|ensembl:ENSP00000503457|ensembl:ENSP00000504448 psi-mi:f_hcv77(display_long)|uniprotkb:Alternate reading frame protein/F-protein(gene name synonym)|uniprotkb:Frameshifted protein(gene name synonym)|uniprotkb:p16(gene name synonym)|uniprotkb:p17(gene name synonym) psi-mi:siat1_human(display_long)|uniprotkb:ST6GAL1(gene name)|psi-mi:ST6GAL1(display_short)|uniprotkb:SIAT1(gene name synonym)|uniprotkb:B-cell antigen CD75(gene name synonym)|uniprotkb:CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,6-sialyltransferase 1(gene name synonym)|uniprotkb:ST6Gal I(gene name synonym)|uniprotkb:Sialyltransferase 1(gene name synonym) psi-mi:"MI:0018"(two hybrid) Huang et al. (2005) imex:IM-23791|pubmed:16237761 taxid:63746(HCV77)|taxid:63746("Hepatitis C virus genotype 1a (isolate H77)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:1335"(HPIDb) intact:EBI-9351998|imex:IM-23791-6 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR002522(Hepatitis C virus capsid protein)|go:"GO:0001848"(complement binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0019028"(viral capsid)|go:"GO:0019899"(enzyme binding)|go:"GO:0031267"(small GTPase binding)|go:"GO:0035375"(zymogen binding)|go:"GO:0039540"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of host RIG-I activity)|go:"GO:0042025"(host cell nucleus)|go:"GO:0044220"(host cell perinuclear region of cytoplasm)|go:"GO:0051494"(negative regulation of cytoskeleton organization)|go:"GO:0097655"(serpin family protein binding) refseq:XP_006713797.1|refseq:XP_011511387.1|refseq:XP_011511388.1|refseq:NP_003023.1|refseq:NP_775323.1|refseq:NP_775324.1|refseq:XP_005247776.1|refseq:XP_005247777.1|refseq:XP_016862554.1|refseq:XP_016862555.1|refseq:XP_016862556.1|refseq:XP_016862557.1|ensembl:ENSG00000073849(gene)|ensembl:ENST00000169298(transcript)|ensembl:ENST00000416235(transcript)|ensembl:ENST00000448044(transcript)|ensembl:ENST00000676633(transcript)|ensembl:ENST00000677292(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0003835"(beta-galactoside alpha-2,6-sialyltransferase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0006054"(N-acetylneuraminate metabolic process)|go:"GO:0006959"(humoral immune response)|go:"GO:0008373"(sialyltransferase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016266"(O-glycan processing)|go:"GO:0018279"(protein N-linked glycosylation via asparagine)|go:"GO:0019082"(viral protein processing)|go:"GO:0032580"(Golgi cisterna membrane)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0097503"(sialylation)|interpro:IPR001675(Glycosyl transferase, family 29)|interpro:IPR012163(Sialyltransferase)|interpro:IPR038578|rcsb pdb:4JS1|rcsb pdb:4JS2|rcsb pdb:6QVS|rcsb pdb:6QVT|reactome:R-HSA-4085001|reactome:R-HSA-9683673|reactome:R-HSA-9694548|reactome:R-HSA-9694719|reactome:R-HSA-975577|reactome:R-HSA-977068 - - - figure legend:Table 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2014/04/04 2015/02/26 rogid:UBoCmCg80GlVxpcs3q93gqjcUGk63746 rogid:RcftRTkKYrV+TlPOrnDSrEvVrkE9606 intact-crc:ED9EDB9B715D5979|rigid:uNY9uq3HpXgT2Wb+hEKF8PlhI2U false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:P51522 uniprotkb:P0C045 intact:EBI-3446875|uniprotkb:Q6PI08|uniprotkb:Q3ZCX0|uniprotkb:A8MT75|ensembl:ENSP00000301096|ensembl:ENSP00000439681|ensembl:ENSP00000440713|ensembl:ENSP00000445993|ensembl:ENSP00000472619 intact:EBI-9351969 psi-mi:znf83_human(display_long)|uniprotkb:ZNF83(gene name)|psi-mi:ZNF83(display_short)|uniprotkb:ZNF816B(gene name synonym)|uniprotkb:Zinc finger protein 816B(gene name synonym)|uniprotkb:Zinc finger protein HPF1(gene name synonym) psi-mi:f_hcv77(display_long)|uniprotkb:Alternate reading frame protein/F-protein(gene name synonym)|uniprotkb:Frameshifted protein(gene name synonym)|uniprotkb:p16(gene name synonym)|uniprotkb:p17(gene name synonym) psi-mi:"MI:0018"(two hybrid) Huang et al. (2005) imex:IM-23791|pubmed:16237761 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:63746(HCV77)|taxid:63746("Hepatitis C virus genotype 1a (isolate H77)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:1335"(HPIDb) intact:EBI-9352002|imex:IM-23791-7 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001264874.1|refseq:NP_001264875.1|refseq:NP_001264876.1|refseq:NP_001264877.1|refseq:NP_001264878.1|refseq:NP_001264880.1|refseq:NP_001264881.1|refseq:NP_001099019.1|refseq:NP_001099020.1|refseq:NP_001099021.1|refseq:NP_001099022.1|refseq:NP_060770.3|refseq:NP_001334944.1|refseq:NP_001334945.1|refseq:NP_001334946.1|refseq:NP_001334947.1|refseq:NP_001334948.1|ensembl:ENSG00000167766(gene)|ensembl:ENST00000301096(transcript)|ensembl:ENST00000536937(transcript)|ensembl:ENST00000541777(transcript)|ensembl:ENST00000545872(transcript)|ensembl:ENST00000597597(transcript)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036236 interpro:IPR002522(Hepatitis C virus capsid protein)|go:"GO:0001848"(complement binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0019028"(viral capsid)|go:"GO:0019899"(enzyme binding)|go:"GO:0031267"(small GTPase binding)|go:"GO:0035375"(zymogen binding)|go:"GO:0039540"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of host RIG-I activity)|go:"GO:0042025"(host cell nucleus)|go:"GO:0044220"(host cell perinuclear region of cytoplasm)|go:"GO:0051494"(negative regulation of cytoskeleton organization)|go:"GO:0097655"(serpin family protein binding) - - - figure legend:Table 1|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)") - 2014/04/04 2015/02/26 rogid:nkcn1TvVIP2ylkR80Yb8WaG/Euc9606 rogid:UBoCmCg80GlVxpcs3q93gqjcUGk63746 intact-crc:A652B9603DD79695|rigid:X1yMCCiMrkMQ9/VRKrAbMdJUKwQ false - - - - psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification) uniprotkb:Q63HM2 uniprotkb:P0C045 intact:EBI-1104540|uniprotkb:Q9BQG8|uniprotkb:Q9H9F2|uniprotkb:A8MXM2|ensembl:ENSP00000384801 intact:EBI-9351969 psi-mi:pcx4_human(display_long)|uniprotkb:PCNX4(gene name)|psi-mi:PCNX4(display_short)|uniprotkb:C14orf135(gene name synonym)|uniprotkb:FBP2(gene name synonym)|uniprotkb:Hepatitis C virus F protein-binding protein 2(gene name synonym)|uniprotkb:PCNXL4(gene name synonym)|uniprotkb:Pecanex homolog protein 4(gene name synonym) psi-mi:f_hcv77(display_long)|uniprotkb:Alternate reading frame protein/F-protein(gene name synonym)|uniprotkb:Frameshifted protein(gene name synonym)|uniprotkb:p16(gene name synonym)|uniprotkb:p17(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Huang et al. (2005) imex:IM-23791|pubmed:16237761 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:63746(HCV77)|taxid:63746("Hepatitis C virus genotype 1a (isolate H77)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:1335"(HPIDb) intact:EBI-9352066|imex:IM-23791-13 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000126773(gene)|ensembl:ENST00000406854(transcript)|go:"GO:0016021"(integral component of membrane)|interpro:IPR007735(Pecanex)|interpro:IPR039797|refseq:NP_071940.4|refseq:NP_001317106.1 interpro:IPR002522(Hepatitis C virus capsid protein)|go:"GO:0001848"(complement binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0019028"(viral capsid)|go:"GO:0019899"(enzyme binding)|go:"GO:0031267"(small GTPase binding)|go:"GO:0035375"(zymogen binding)|go:"GO:0039540"(suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of host RIG-I activity)|go:"GO:0042025"(host cell nucleus)|go:"GO:0044220"(host cell perinuclear region of cytoplasm)|go:"GO:0051494"(negative regulation of cytoskeleton organization)|go:"GO:0097655"(serpin family protein binding) - - - figure legend:5|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2014/04/04 2015/02/26 rogid:rf5CFSLdXxG+w6Uyr6+pbvD090E9606 rogid:UBoCmCg80GlVxpcs3q93gqjcUGk63746 intact-crc:9B05437E8DB330AC|rigid:tVdxh2Cw7Zidc3GUhNaaRlboLXs false - gal4 dna binding domain:n-n|myc tag:n-n - - psi-mi:"MI:0833"(autoradiography) psi-mi:"MI:0833"(autoradiography)