#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P63316	uniprotkb:P19429	intact:EBI-3906339|uniprotkb:P02590|uniprotkb:P04463|uniprotkb:O14800|ensembl:ENSP00000232975	intact:EBI-704146|ensembl:ENSP00000341838	psi-mi:tnnc1_human(display_long)|uniprotkb:TNNC1(gene name)|psi-mi:TNNC1(display_short)|uniprotkb:TNNC(gene name synonym)	psi-mi:tnni3_human(display_long)|uniprotkb:Cardiac troponin I(gene name synonym)|uniprotkb:TNNI3(gene name)|psi-mi:TNNI3(display_short)|uniprotkb:TNNC1(gene name synonym)	psi-mi:"MI:0114"(x-ray crystallography)	Takeda et al. (2003)	pubmed:12840750|imex:IM-23511	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9994169|imex:IM-23511-2|pdbe:1j1d	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_003271.1|ensembl:ENSG00000114854(gene)|ensembl:ENST00000232975(transcript)|go:"GO:0002086"(diaphragm contraction)|go:"GO:0003009"(skeletal muscle contraction)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005829"(cytosol)|go:"GO:0005861"(troponin complex)|go:"GO:0006937"(regulation of muscle contraction)|go:"GO:0010038"(response to metal ion)|go:"GO:0014883"(transition between fast and slow fiber)|go:"GO:0031013"(troponin I binding)|go:"GO:0031014"(troponin T binding)|go:"GO:0032972"(regulation of muscle filament sliding speed)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043462"(regulation of ATP-dependent activity)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0051015"(actin filament binding)|go:"GO:0055010"(ventricular cardiac muscle tissue morphogenesis)|go:"GO:0060048"(cardiac muscle contraction)|go:"GO:1990584"(cardiac Troponin complex)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|rcsb pdb:1AP4|rcsb pdb:1IH0|rcsb pdb:1J1D|rcsb pdb:1J1E|rcsb pdb:1LXF|rcsb pdb:1MXL|rcsb pdb:1OZS|rcsb pdb:1SPY|rcsb pdb:1WRK|rcsb pdb:1WRL|rcsb pdb:2JT0|rcsb pdb:2JT3|rcsb pdb:2JT8|rcsb pdb:2JTZ|rcsb pdb:2JXL|rcsb pdb:2KDH|rcsb pdb:2KFX|rcsb pdb:2KGB|rcsb pdb:2KRD|rcsb pdb:2L1R|rcsb pdb:2L98|rcsb pdb:2MKP|rcsb pdb:2MLE|rcsb pdb:2MLF|rcsb pdb:2MZP|rcsb pdb:2N79|rcsb pdb:2N7L|rcsb pdb:3RV5|rcsb pdb:3SD6|rcsb pdb:3SWB|rcsb pdb:4GJE|rcsb pdb:4GJF|rcsb pdb:4GJG|rcsb pdb:4Y99|rcsb pdb:5VLN|rcsb pdb:5W88|rcsb pdb:5WCL|rcsb pdb:6KN7|rcsb pdb:6KN8|rcsb pdb:6MV3|rcsb pdb:7JGI|reactome:R-HSA-390522	refseq:NP_000354.4|dip:DIP-34065N|ensembl:ENSG00000129991(gene)|ensembl:ENST00000344887(transcript)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001980"(regulation of systemic arterial blood pressure by ischemic conditions)|go:"GO:0003009"(skeletal muscle contraction)|go:"GO:0003779"(actin binding)|go:"GO:0005829"(cytosol)|go:"GO:0005861"(troponin complex)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006936"(muscle contraction)|go:"GO:0006940"(regulation of smooth muscle contraction)|go:"GO:0007507"(heart development)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0019855"(calcium channel inhibitor activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030172"(troponin C binding)|go:"GO:0031014"(troponin T binding)|go:"GO:0032780"(negative regulation of ATP-dependent activity)|go:"GO:0046872"(metal ion binding)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0051015"(actin filament binding)|go:"GO:0055010"(ventricular cardiac muscle tissue morphogenesis)|go:"GO:0060047"(heart contraction)|go:"GO:0060048"(cardiac muscle contraction)|go:"GO:0097512"(cardiac myofibril)|go:"GO:1990584"(cardiac Troponin complex)|interpro:IPR001978(Troponin)|interpro:IPR021666|interpro:IPR038077|mint:P19429|rcsb pdb:1J1D|rcsb pdb:1J1E|rcsb pdb:1LXF|rcsb pdb:1MXL|rcsb pdb:1OZS|rcsb pdb:2KGB|rcsb pdb:2KRD|rcsb pdb:2L1R|rcsb pdb:2MZP|rcsb pdb:2N7L|rcsb pdb:4Y99|rcsb pdb:5VLN|rcsb pdb:5W88|rcsb pdb:5WCL|rcsb pdb:6KN7|rcsb pdb:6KN8|rcsb pdb:6MV3|rcsb pdb:7JGI|reactome:R-HSA-390522|reactome:R-HSA-5578775	-	-	-	figure legend:Table 1|3d-resolution:2.6 angstrom|3d-r-factors:Rwork = 0.26  Rfree = 0.30|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/11/19	2014/12/02	rogid:XsWAxSgP8gvX6F0jwWQxFk4skkU9606	rogid:kLAHLvln+lIzJRQ8Dit1sSKw/6Y9606	intact-crc:F3BAC394FE89F6B3|rigid:XFh2dK3VFm+MWnTJ3zCiJWQDOXU	false	-	sufficient binding region:31-163(IPR001978)	1	1	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P63316	uniprotkb:P45379	intact:EBI-3906339|uniprotkb:P02590|uniprotkb:P04463|uniprotkb:O14800|ensembl:ENSP00000232975	intact:EBI-8485957|uniprotkb:A2TDB9|uniprotkb:Q9BUF6|intact:MINT-3015968|uniprotkb:O60214|uniprotkb:Q9UM96|uniprotkb:Q99597|uniprotkb:Q99596|uniprotkb:A8K3K6|ensembl:ENSP00000236918|ensembl:ENSP00000499593	psi-mi:tnnc1_human(display_long)|uniprotkb:TNNC1(gene name)|psi-mi:TNNC1(display_short)|uniprotkb:TNNC(gene name synonym)	psi-mi:tnnt2_human(display_long)|uniprotkb:TNNT2(gene name)|psi-mi:TNNT2(display_short)|uniprotkb:Cardiac muscle troponin T(gene name synonym)	psi-mi:"MI:0114"(x-ray crystallography)	Takeda et al. (2003)	pubmed:12840750|imex:IM-23511	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9994169|imex:IM-23511-2|pdbe:1j1d	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_003271.1|ensembl:ENSG00000114854(gene)|ensembl:ENST00000232975(transcript)|go:"GO:0002086"(diaphragm contraction)|go:"GO:0003009"(skeletal muscle contraction)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005829"(cytosol)|go:"GO:0005861"(troponin complex)|go:"GO:0006937"(regulation of muscle contraction)|go:"GO:0010038"(response to metal ion)|go:"GO:0014883"(transition between fast and slow fiber)|go:"GO:0031013"(troponin I binding)|go:"GO:0031014"(troponin T binding)|go:"GO:0032972"(regulation of muscle filament sliding speed)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043462"(regulation of ATP-dependent activity)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0051015"(actin filament binding)|go:"GO:0055010"(ventricular cardiac muscle tissue morphogenesis)|go:"GO:0060048"(cardiac muscle contraction)|go:"GO:1990584"(cardiac Troponin complex)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|rcsb pdb:1AP4|rcsb pdb:1IH0|rcsb pdb:1J1D|rcsb pdb:1J1E|rcsb pdb:1LXF|rcsb pdb:1MXL|rcsb pdb:1OZS|rcsb pdb:1SPY|rcsb pdb:1WRK|rcsb pdb:1WRL|rcsb pdb:2JT0|rcsb pdb:2JT3|rcsb pdb:2JT8|rcsb pdb:2JTZ|rcsb pdb:2JXL|rcsb pdb:2KDH|rcsb pdb:2KFX|rcsb pdb:2KGB|rcsb pdb:2KRD|rcsb pdb:2L1R|rcsb pdb:2L98|rcsb pdb:2MKP|rcsb pdb:2MLE|rcsb pdb:2MLF|rcsb pdb:2MZP|rcsb pdb:2N79|rcsb pdb:2N7L|rcsb pdb:3RV5|rcsb pdb:3SD6|rcsb pdb:3SWB|rcsb pdb:4GJE|rcsb pdb:4GJF|rcsb pdb:4GJG|rcsb pdb:4Y99|rcsb pdb:5VLN|rcsb pdb:5W88|rcsb pdb:5WCL|rcsb pdb:6KN7|rcsb pdb:6KN8|rcsb pdb:6MV3|rcsb pdb:7JGI|reactome:R-HSA-390522	refseq:XP_011508240.1|refseq:XP_011508241.1|refseq:XP_011508242.1|refseq:XP_011508244.1|refseq:XP_011508245.1|refseq:NP_001001430.1|refseq:NP_001263276.1|refseq:NP_000355.2|refseq:NP_001263274.1|refseq:NP_001001432.1|refseq:NP_001263275.1|refseq:NP_001001431.1|refseq:XP_006711571.1|refseq:XP_016857706.1|ensembl:ENSG00000118194(gene)|ensembl:ENST00000236918(transcript)|ensembl:ENST00000656932(transcript)|go:"GO:0003779"(actin binding)|go:"GO:0005523"(tropomyosin binding)|go:"GO:0005829"(cytosol)|go:"GO:0005861"(troponin complex)|go:"GO:0005865"(striated muscle thin filament)|go:"GO:0006936"(muscle contraction)|go:"GO:0008016"(regulation of heart contraction)|go:"GO:0030017"(sarcomere)|go:"GO:0030049"(muscle filament sliding)|go:"GO:0030172"(troponin C binding)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031013"(troponin I binding)|go:"GO:0032780"(negative regulation of ATP-dependent activity)|go:"GO:0032781"(positive regulation of ATP-dependent activity)|go:"GO:0032972"(regulation of muscle filament sliding speed)|go:"GO:0042802"(identical protein binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045214"(sarcomere organization)|go:"GO:0051592"(response to calcium ion)|go:"GO:0051764"(actin crosslink formation)|go:"GO:0055010"(ventricular cardiac muscle tissue morphogenesis)|go:"GO:0060048"(cardiac muscle contraction)|go:"GO:0097512"(cardiac myofibril)|go:"GO:1990584"(cardiac Troponin complex)|interpro:IPR001978(Troponin)|interpro:IPR027707|interpro:IPR038077|mint:P45379|rcsb pdb:1J1D|rcsb pdb:1J1E|rcsb pdb:4Y99|rcsb pdb:6KN7|rcsb pdb:6KN8|reactome:R-HSA-390522	-	-	comment:mint|function:Troponin T is the tropomyosin-binding subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity|comment:homomint|function:"Defects in TNNT2 are the cause of familial hypertrophic cardiomyopathy type 2 (CMH2) [MIM:115195]; also designated FHC or HCM. Familial hypertrophic cardiomyopathy [MIM:192600] is a heart disorder characterized by ventricular hypertrophy, which is usually asymmetric and often involves the interventricular septum. The prevalence of the disease in the general population is 0.2%. FHC is clinically heterogeneous, with inter- and intrafamilial variations ranging from benign to malignant forms with high risk of cardiac failure and sudden cardiac death"|function:"Defects in TNNT2 are the cause of dilated cardiomyopathy 1D (CMD1D) [MIM:601494]. Dilated cardiomyopathy [MIM:115200] is a disorder characterized by cardiac dilation and reduced systolic function. CMD1D inheritance is autosomal dominant"	figure legend:Table 1|3d-resolution:2.6 angstrom|3d-r-factors:Rwork = 0.26  Rfree = 0.30|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/11/19	2014/12/02	rogid:XsWAxSgP8gvX6F0jwWQxFk4skkU9606	rogid:XAGEQ8o/Fy1PAMaixBpaLTfS1Rw9606	intact-crc:F3BAC394FE89F6B3|rigid:XFh2dK3VFm+MWnTJ3zCiJWQDOXU	false	-	sufficient binding region:183-288	1	1	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P63316	uniprotkb:P19429	intact:EBI-3906339|uniprotkb:P02590|uniprotkb:P04463|uniprotkb:O14800|ensembl:ENSP00000232975	intact:EBI-704146|ensembl:ENSP00000341838	psi-mi:tnnc1_human(display_long)|uniprotkb:TNNC1(gene name)|psi-mi:TNNC1(display_short)|uniprotkb:TNNC(gene name synonym)	psi-mi:tnni3_human(display_long)|uniprotkb:Cardiac troponin I(gene name synonym)|uniprotkb:TNNI3(gene name)|psi-mi:TNNI3(display_short)|uniprotkb:TNNC1(gene name synonym)	psi-mi:"MI:0114"(x-ray crystallography)	Takeda et al. (2003)	pubmed:12840750|imex:IM-23511	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9980802|pdbe:1j1e|imex:IM-23511-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_003271.1|ensembl:ENSG00000114854(gene)|ensembl:ENST00000232975(transcript)|go:"GO:0002086"(diaphragm contraction)|go:"GO:0003009"(skeletal muscle contraction)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005829"(cytosol)|go:"GO:0005861"(troponin complex)|go:"GO:0006937"(regulation of muscle contraction)|go:"GO:0010038"(response to metal ion)|go:"GO:0014883"(transition between fast and slow fiber)|go:"GO:0031013"(troponin I binding)|go:"GO:0031014"(troponin T binding)|go:"GO:0032972"(regulation of muscle filament sliding speed)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043462"(regulation of ATP-dependent activity)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0051015"(actin filament binding)|go:"GO:0055010"(ventricular cardiac muscle tissue morphogenesis)|go:"GO:0060048"(cardiac muscle contraction)|go:"GO:1990584"(cardiac Troponin complex)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|rcsb pdb:1AP4|rcsb pdb:1IH0|rcsb pdb:1J1D|rcsb pdb:1J1E|rcsb pdb:1LXF|rcsb pdb:1MXL|rcsb pdb:1OZS|rcsb pdb:1SPY|rcsb pdb:1WRK|rcsb pdb:1WRL|rcsb pdb:2JT0|rcsb pdb:2JT3|rcsb pdb:2JT8|rcsb pdb:2JTZ|rcsb pdb:2JXL|rcsb pdb:2KDH|rcsb pdb:2KFX|rcsb pdb:2KGB|rcsb pdb:2KRD|rcsb pdb:2L1R|rcsb pdb:2L98|rcsb pdb:2MKP|rcsb pdb:2MLE|rcsb pdb:2MLF|rcsb pdb:2MZP|rcsb pdb:2N79|rcsb pdb:2N7L|rcsb pdb:3RV5|rcsb pdb:3SD6|rcsb pdb:3SWB|rcsb pdb:4GJE|rcsb pdb:4GJF|rcsb pdb:4GJG|rcsb pdb:4Y99|rcsb pdb:5VLN|rcsb pdb:5W88|rcsb pdb:5WCL|rcsb pdb:6KN7|rcsb pdb:6KN8|rcsb pdb:6MV3|rcsb pdb:7JGI|reactome:R-HSA-390522	refseq:NP_000354.4|dip:DIP-34065N|ensembl:ENSG00000129991(gene)|ensembl:ENST00000344887(transcript)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001980"(regulation of systemic arterial blood pressure by ischemic conditions)|go:"GO:0003009"(skeletal muscle contraction)|go:"GO:0003779"(actin binding)|go:"GO:0005829"(cytosol)|go:"GO:0005861"(troponin complex)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006936"(muscle contraction)|go:"GO:0006940"(regulation of smooth muscle contraction)|go:"GO:0007507"(heart development)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0019855"(calcium channel inhibitor activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030172"(troponin C binding)|go:"GO:0031014"(troponin T binding)|go:"GO:0032780"(negative regulation of ATP-dependent activity)|go:"GO:0046872"(metal ion binding)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0051015"(actin filament binding)|go:"GO:0055010"(ventricular cardiac muscle tissue morphogenesis)|go:"GO:0060047"(heart contraction)|go:"GO:0060048"(cardiac muscle contraction)|go:"GO:0097512"(cardiac myofibril)|go:"GO:1990584"(cardiac Troponin complex)|interpro:IPR001978(Troponin)|interpro:IPR021666|interpro:IPR038077|mint:P19429|rcsb pdb:1J1D|rcsb pdb:1J1E|rcsb pdb:1LXF|rcsb pdb:1MXL|rcsb pdb:1OZS|rcsb pdb:2KGB|rcsb pdb:2KRD|rcsb pdb:2L1R|rcsb pdb:2MZP|rcsb pdb:2N7L|rcsb pdb:4Y99|rcsb pdb:5VLN|rcsb pdb:5W88|rcsb pdb:5WCL|rcsb pdb:6KN7|rcsb pdb:6KN8|rcsb pdb:6MV3|rcsb pdb:7JGI|reactome:R-HSA-390522|reactome:R-HSA-5578775	-	-	-	figure legend:Table 1|3d-resolution:3.3 angstrom|3d-r-factors:Rwork = 0.25 Rfree = 0.31|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/11/19	2014/12/02	rogid:XsWAxSgP8gvX6F0jwWQxFk4skkU9606	rogid:kLAHLvln+lIzJRQ8Dit1sSKw/6Y9606	intact-crc:BB91305E9F7EF28A|rigid:XFh2dK3VFm+MWnTJ3zCiJWQDOXU	false	-	sufficient binding region:31-210(IPR001978)	1	1	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P63316	uniprotkb:P45379	intact:EBI-3906339|uniprotkb:P02590|uniprotkb:P04463|uniprotkb:O14800|ensembl:ENSP00000232975	intact:EBI-8485957|uniprotkb:A2TDB9|uniprotkb:Q9BUF6|intact:MINT-3015968|uniprotkb:O60214|uniprotkb:Q9UM96|uniprotkb:Q99597|uniprotkb:Q99596|uniprotkb:A8K3K6|ensembl:ENSP00000236918|ensembl:ENSP00000499593	psi-mi:tnnc1_human(display_long)|uniprotkb:TNNC1(gene name)|psi-mi:TNNC1(display_short)|uniprotkb:TNNC(gene name synonym)	psi-mi:tnnt2_human(display_long)|uniprotkb:TNNT2(gene name)|psi-mi:TNNT2(display_short)|uniprotkb:Cardiac muscle troponin T(gene name synonym)	psi-mi:"MI:0114"(x-ray crystallography)	Takeda et al. (2003)	pubmed:12840750|imex:IM-23511	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9980802|pdbe:1j1e|imex:IM-23511-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_003271.1|ensembl:ENSG00000114854(gene)|ensembl:ENST00000232975(transcript)|go:"GO:0002086"(diaphragm contraction)|go:"GO:0003009"(skeletal muscle contraction)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005829"(cytosol)|go:"GO:0005861"(troponin complex)|go:"GO:0006937"(regulation of muscle contraction)|go:"GO:0010038"(response to metal ion)|go:"GO:0014883"(transition between fast and slow fiber)|go:"GO:0031013"(troponin I binding)|go:"GO:0031014"(troponin T binding)|go:"GO:0032972"(regulation of muscle filament sliding speed)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043462"(regulation of ATP-dependent activity)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0051015"(actin filament binding)|go:"GO:0055010"(ventricular cardiac muscle tissue morphogenesis)|go:"GO:0060048"(cardiac muscle contraction)|go:"GO:1990584"(cardiac Troponin complex)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|rcsb pdb:1AP4|rcsb pdb:1IH0|rcsb pdb:1J1D|rcsb pdb:1J1E|rcsb pdb:1LXF|rcsb pdb:1MXL|rcsb pdb:1OZS|rcsb pdb:1SPY|rcsb pdb:1WRK|rcsb pdb:1WRL|rcsb pdb:2JT0|rcsb pdb:2JT3|rcsb pdb:2JT8|rcsb pdb:2JTZ|rcsb pdb:2JXL|rcsb pdb:2KDH|rcsb pdb:2KFX|rcsb pdb:2KGB|rcsb pdb:2KRD|rcsb pdb:2L1R|rcsb pdb:2L98|rcsb pdb:2MKP|rcsb pdb:2MLE|rcsb pdb:2MLF|rcsb pdb:2MZP|rcsb pdb:2N79|rcsb pdb:2N7L|rcsb pdb:3RV5|rcsb pdb:3SD6|rcsb pdb:3SWB|rcsb pdb:4GJE|rcsb pdb:4GJF|rcsb pdb:4GJG|rcsb pdb:4Y99|rcsb pdb:5VLN|rcsb pdb:5W88|rcsb pdb:5WCL|rcsb pdb:6KN7|rcsb pdb:6KN8|rcsb pdb:6MV3|rcsb pdb:7JGI|reactome:R-HSA-390522	refseq:XP_011508240.1|refseq:XP_011508241.1|refseq:XP_011508242.1|refseq:XP_011508244.1|refseq:XP_011508245.1|refseq:NP_001001430.1|refseq:NP_001263276.1|refseq:NP_000355.2|refseq:NP_001263274.1|refseq:NP_001001432.1|refseq:NP_001263275.1|refseq:NP_001001431.1|refseq:XP_006711571.1|refseq:XP_016857706.1|ensembl:ENSG00000118194(gene)|ensembl:ENST00000236918(transcript)|ensembl:ENST00000656932(transcript)|go:"GO:0003779"(actin binding)|go:"GO:0005523"(tropomyosin binding)|go:"GO:0005829"(cytosol)|go:"GO:0005861"(troponin complex)|go:"GO:0005865"(striated muscle thin filament)|go:"GO:0006936"(muscle contraction)|go:"GO:0008016"(regulation of heart contraction)|go:"GO:0030017"(sarcomere)|go:"GO:0030049"(muscle filament sliding)|go:"GO:0030172"(troponin C binding)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031013"(troponin I binding)|go:"GO:0032780"(negative regulation of ATP-dependent activity)|go:"GO:0032781"(positive regulation of ATP-dependent activity)|go:"GO:0032972"(regulation of muscle filament sliding speed)|go:"GO:0042802"(identical protein binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045214"(sarcomere organization)|go:"GO:0051592"(response to calcium ion)|go:"GO:0051764"(actin crosslink formation)|go:"GO:0055010"(ventricular cardiac muscle tissue morphogenesis)|go:"GO:0060048"(cardiac muscle contraction)|go:"GO:0097512"(cardiac myofibril)|go:"GO:1990584"(cardiac Troponin complex)|interpro:IPR001978(Troponin)|interpro:IPR027707|interpro:IPR038077|mint:P45379|rcsb pdb:1J1D|rcsb pdb:1J1E|rcsb pdb:4Y99|rcsb pdb:6KN7|rcsb pdb:6KN8|reactome:R-HSA-390522	-	-	comment:mint|function:Troponin T is the tropomyosin-binding subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity|comment:homomint|function:"Defects in TNNT2 are the cause of familial hypertrophic cardiomyopathy type 2 (CMH2) [MIM:115195]; also designated FHC or HCM. Familial hypertrophic cardiomyopathy [MIM:192600] is a heart disorder characterized by ventricular hypertrophy, which is usually asymmetric and often involves the interventricular septum. The prevalence of the disease in the general population is 0.2%. FHC is clinically heterogeneous, with inter- and intrafamilial variations ranging from benign to malignant forms with high risk of cardiac failure and sudden cardiac death"|function:"Defects in TNNT2 are the cause of dilated cardiomyopathy 1D (CMD1D) [MIM:601494]. Dilated cardiomyopathy [MIM:115200] is a disorder characterized by cardiac dilation and reduced systolic function. CMD1D inheritance is autosomal dominant"	figure legend:Table 1|3d-resolution:3.3 angstrom|3d-r-factors:Rwork = 0.25 Rfree = 0.31|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/11/19	2014/12/02	rogid:XsWAxSgP8gvX6F0jwWQxFk4skkU9606	rogid:XAGEQ8o/Fy1PAMaixBpaLTfS1Rw9606	intact-crc:BB91305E9F7EF28A|rigid:XFh2dK3VFm+MWnTJ3zCiJWQDOXU	false	-	sufficient binding region:183-288	1	1	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)