#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P19838	uniprotkb:P41279	intact:EBI-300010|ensembl:ENSP00000378297|ensembl:ENSP00000424790|uniprotkb:Q68D84|uniprotkb:Q86V43|uniprotkb:Q8N4X7|uniprotkb:Q9NZC0|uniprotkb:A8K5Y5|uniprotkb:B3KVE8	intact:EBI-354900|uniprotkb:Q14275|uniprotkb:Q5T855|uniprotkb:Q9HC81|uniprotkb:A8K2Q5|uniprotkb:D3DRX1|ensembl:ENSP00000263056|ensembl:ENSP00000364470|ensembl:ENSP00000443610	psi-mi:nfkb1_human(display_long)|uniprotkb:NFKB1(gene name)|psi-mi:NFKB1(display_short)|uniprotkb:DNA-binding factor KBF1(gene name synonym)|uniprotkb:EBP-1(gene name synonym)|uniprotkb:Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1(gene name synonym)	psi-mi:m3k8_human(display_long)|uniprotkb:MAP3K8(gene name)|psi-mi:MAP3K8(display_short)|uniprotkb:COT(gene name synonym)|uniprotkb:ESTF(gene name synonym)|uniprotkb:Serine/threonine-protein kinase cot(gene name synonym)|uniprotkb:Cancer Osaka thyroid oncogene(gene name synonym)|uniprotkb:Tumor progression locus 2(gene name synonym)|uniprotkb:Proto-oncogene c-Cot(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Beinke et al. (2003)	imex:IM-23220|pubmed:12832462	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9868221|imex:IM-23220-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	reactome:R-HSA-5603029|reactome:R-HSA-5607764|reactome:R-HSA-5621575|reactome:R-HSA-5660668|reactome:R-HSA-5684264|reactome:R-HSA-6798695|reactome:R-HSA-844456|reactome:R-HSA-8853884|reactome:R-HSA-9020702|reactome:R-HSA-933542|reactome:R-HSA-9609690|reactome:R-HSA-9660826|reactome:R-HSA-448706|ensembl:ENSG00000109320(gene)|ensembl:ENST00000394820(transcript)|ensembl:ENST00000505458(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001223"(transcription coactivator binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010744"(positive regulation of macrophage derived foam cell differentiation)|go:"GO:0010884"(positive regulation of lipid storage)|go:"GO:0010956"(negative regulation of calcidiol 1-monooxygenase activity)|go:"GO:0010957"(negative regulation of vitamin D biosynthetic process)|go:"GO:0019899"(enzyme binding)|go:"GO:0032269"(negative regulation of cellular protein metabolic process)|go:"GO:0032375"(negative regulation of cholesterol transport)|go:"GO:0032695"(negative regulation of interleukin-12 production)|go:"GO:0033256"(I-kappaB/NF-kappaB complex)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0035580"(specific granule lumen)|go:"GO:0035994"(response to muscle stretch)|go:"GO:0042802"(identical protein binding)|go:"GO:0042805"(actinin binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071316"(cellular response to nicotine)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071354"(cellular response to interleukin-6)|go:"GO:0071356"(cellular response to tumor necrosis factor)|interpro:IPR000488(Death)|interpro:IPR002110(Ankyrin)|interpro:IPR002909(Cell surface receptor IPT/TIG)|go:"GO:0071359"(cellular response to dsRNA)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR011029(DEATH-like)|interpro:IPR011539(Rel homology)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR020683|interpro:IPR030492|interpro:IPR030503|go:"GO:1900127"(positive regulation of hyaluronan biosynthetic process)|go:"GO:1904385"(cellular response to angiotensin)|interpro:IPR032397|interpro:IPR033926|interpro:IPR036770|interpro:IPR037059|mint:P19838|rcsb pdb:1MDI|rcsb pdb:1MDJ|rcsb pdb:1MDK|rcsb pdb:1NFI|rcsb pdb:1SVC|rcsb pdb:2DBF|rcsb pdb:2O61|rcsb pdb:3GUT|reactome:R-HSA-1169091|reactome:R-HSA-1810476|reactome:R-HSA-193692|reactome:R-HSA-202424|reactome:R-HSA-209560|reactome:R-HSA-2559582|reactome:R-HSA-2871837|go:"GO:2000630"(positive regulation of miRNA metabolic process)|interpro:IPR000451(NF-kappa-B/Rel/dorsal)|reactome:R-HSA-3134963|reactome:R-HSA-3214841|reactome:R-HSA-381340|reactome:R-HSA-445989|refseq:NP_001158884.1|refseq:NP_003989.2|refseq:NP_001306155.1|dip:DIP-106N	refseq:NP_005195.2|refseq:NP_001231063.1|go:"GO:0031295"(T cell costimulation)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017424(Mitogen-activated protein kinase kinase kinase 8)|rcsb pdb:4Y83|rcsb pdb:4Y85|rcsb pdb:5IU2|reactome:R-HSA-389357|reactome:R-HSA-5684264|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007049"(cell cycle)|ensembl:ENSG00000107968(gene)|ensembl:ENST00000263056(transcript)|ensembl:ENST00000375321(transcript)|ensembl:ENST00000542547(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|refseq:NP_001307890.1|refseq:XP_016871196.1|refseq:XP_016871197.1|refseq:XP_016871198.1|refseq:XP_016871199.1|dip:DIP-27534N	-	-	-	figure legend:Fig. 1|dataset:IBD - Inflammatory bowel disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2014/10/20	2014/11/24	rogid:Kb83YHl5j5+iZl8v3ERcD8CGNH89606	rogid:jioNJRDtKJU8iwI+dNq4JSEHRoI9606	intact-crc:8BD5EA32D2AC59D1|rigid:xjbc+xuQURIod6Md2izNQnx2gmU	false	ha tag:n-n	sufficient binding region:131-398(IPR000719)|myc tag:n-n|mutation decreasing interaction:270-270	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P41279	uniprotkb:P19838	intact:EBI-354900|uniprotkb:Q14275|uniprotkb:Q5T855|uniprotkb:Q9HC81|uniprotkb:A8K2Q5|uniprotkb:D3DRX1|ensembl:ENSP00000263056|ensembl:ENSP00000364470|ensembl:ENSP00000443610	intact:EBI-300010|ensembl:ENSP00000378297|ensembl:ENSP00000424790|uniprotkb:Q68D84|uniprotkb:Q86V43|uniprotkb:Q8N4X7|uniprotkb:Q9NZC0|uniprotkb:A8K5Y5|uniprotkb:B3KVE8	psi-mi:m3k8_human(display_long)|uniprotkb:MAP3K8(gene name)|psi-mi:MAP3K8(display_short)|uniprotkb:COT(gene name synonym)|uniprotkb:ESTF(gene name synonym)|uniprotkb:Serine/threonine-protein kinase cot(gene name synonym)|uniprotkb:Cancer Osaka thyroid oncogene(gene name synonym)|uniprotkb:Tumor progression locus 2(gene name synonym)|uniprotkb:Proto-oncogene c-Cot(gene name synonym)	psi-mi:nfkb1_human(display_long)|uniprotkb:NFKB1(gene name)|psi-mi:NFKB1(display_short)|uniprotkb:DNA-binding factor KBF1(gene name synonym)|uniprotkb:EBP-1(gene name synonym)|uniprotkb:Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Beinke et al. (2003)	imex:IM-23220|pubmed:12832462	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9984694|imex:IM-23220-6	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005195.2|refseq:NP_001231063.1|go:"GO:0031295"(T cell costimulation)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017424(Mitogen-activated protein kinase kinase kinase 8)|rcsb pdb:4Y83|rcsb pdb:4Y85|rcsb pdb:5IU2|reactome:R-HSA-389357|reactome:R-HSA-5684264|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007049"(cell cycle)|ensembl:ENSG00000107968(gene)|ensembl:ENST00000263056(transcript)|ensembl:ENST00000375321(transcript)|ensembl:ENST00000542547(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|refseq:NP_001307890.1|refseq:XP_016871196.1|refseq:XP_016871197.1|refseq:XP_016871198.1|refseq:XP_016871199.1|dip:DIP-27534N	reactome:R-HSA-5603029|reactome:R-HSA-5607764|reactome:R-HSA-5621575|reactome:R-HSA-5660668|reactome:R-HSA-5684264|reactome:R-HSA-6798695|reactome:R-HSA-844456|reactome:R-HSA-8853884|reactome:R-HSA-9020702|reactome:R-HSA-933542|reactome:R-HSA-9609690|reactome:R-HSA-9660826|reactome:R-HSA-448706|ensembl:ENSG00000109320(gene)|ensembl:ENST00000394820(transcript)|ensembl:ENST00000505458(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001223"(transcription coactivator binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010744"(positive regulation of macrophage derived foam cell differentiation)|go:"GO:0010884"(positive regulation of lipid storage)|go:"GO:0010956"(negative regulation of calcidiol 1-monooxygenase activity)|go:"GO:0010957"(negative regulation of vitamin D biosynthetic process)|go:"GO:0019899"(enzyme binding)|go:"GO:0032269"(negative regulation of cellular protein metabolic process)|go:"GO:0032375"(negative regulation of cholesterol transport)|go:"GO:0032695"(negative regulation of interleukin-12 production)|go:"GO:0033256"(I-kappaB/NF-kappaB complex)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0035580"(specific granule lumen)|go:"GO:0035994"(response to muscle stretch)|go:"GO:0042802"(identical protein binding)|go:"GO:0042805"(actinin binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071316"(cellular response to nicotine)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071354"(cellular response to interleukin-6)|go:"GO:0071356"(cellular response to tumor necrosis factor)|interpro:IPR000488(Death)|interpro:IPR002110(Ankyrin)|interpro:IPR002909(Cell surface receptor IPT/TIG)|go:"GO:0071359"(cellular response to dsRNA)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR011029(DEATH-like)|interpro:IPR011539(Rel homology)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR020683|interpro:IPR030492|interpro:IPR030503|go:"GO:1900127"(positive regulation of hyaluronan biosynthetic process)|go:"GO:1904385"(cellular response to angiotensin)|interpro:IPR032397|interpro:IPR033926|interpro:IPR036770|interpro:IPR037059|mint:P19838|rcsb pdb:1MDI|rcsb pdb:1MDJ|rcsb pdb:1MDK|rcsb pdb:1NFI|rcsb pdb:1SVC|rcsb pdb:2DBF|rcsb pdb:2O61|rcsb pdb:3GUT|reactome:R-HSA-1169091|reactome:R-HSA-1810476|reactome:R-HSA-193692|reactome:R-HSA-202424|reactome:R-HSA-209560|reactome:R-HSA-2559582|reactome:R-HSA-2871837|go:"GO:2000630"(positive regulation of miRNA metabolic process)|interpro:IPR000451(NF-kappa-B/Rel/dorsal)|reactome:R-HSA-3134963|reactome:R-HSA-3214841|reactome:R-HSA-381340|reactome:R-HSA-445989|refseq:NP_001158884.1|refseq:NP_003989.2|refseq:NP_001306155.1|dip:DIP-106N	-	-	-	figure legend:Fig. 2b|dataset:IBD - Inflammatory bowel disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2014/10/20	2014/11/24	rogid:jioNJRDtKJU8iwI+dNq4JSEHRoI9606	rogid:Kb83YHl5j5+iZl8v3ERcD8CGNH89606	intact-crc:6400E1F690EAB2C0|rigid:xjbc+xuQURIod6Md2izNQnx2gmU	false	sufficient binding region:1-398|myc tag:n-n	mutation decreasing interaction:841-841|ha tag:n-n|necessary binding region:802-892(IPR000488)	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P19838	uniprotkb:P41279	intact:EBI-300010|ensembl:ENSP00000378297|ensembl:ENSP00000424790|uniprotkb:Q68D84|uniprotkb:Q86V43|uniprotkb:Q8N4X7|uniprotkb:Q9NZC0|uniprotkb:A8K5Y5|uniprotkb:B3KVE8	intact:EBI-354900|uniprotkb:Q14275|uniprotkb:Q5T855|uniprotkb:Q9HC81|uniprotkb:A8K2Q5|uniprotkb:D3DRX1|ensembl:ENSP00000263056|ensembl:ENSP00000364470|ensembl:ENSP00000443610	psi-mi:nfkb1_human(display_long)|uniprotkb:NFKB1(gene name)|psi-mi:NFKB1(display_short)|uniprotkb:DNA-binding factor KBF1(gene name synonym)|uniprotkb:EBP-1(gene name synonym)|uniprotkb:Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1(gene name synonym)	psi-mi:m3k8_human(display_long)|uniprotkb:MAP3K8(gene name)|psi-mi:MAP3K8(display_short)|uniprotkb:COT(gene name synonym)|uniprotkb:ESTF(gene name synonym)|uniprotkb:Serine/threonine-protein kinase cot(gene name synonym)|uniprotkb:Cancer Osaka thyroid oncogene(gene name synonym)|uniprotkb:Tumor progression locus 2(gene name synonym)|uniprotkb:Proto-oncogene c-Cot(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Beinke et al. (2003)	imex:IM-23220|pubmed:12832462	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9984752|imex:IM-23220-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	reactome:R-HSA-5603029|reactome:R-HSA-5607764|reactome:R-HSA-5621575|reactome:R-HSA-5660668|reactome:R-HSA-5684264|reactome:R-HSA-6798695|reactome:R-HSA-844456|reactome:R-HSA-8853884|reactome:R-HSA-9020702|reactome:R-HSA-933542|reactome:R-HSA-9609690|reactome:R-HSA-9660826|reactome:R-HSA-448706|ensembl:ENSG00000109320(gene)|ensembl:ENST00000394820(transcript)|ensembl:ENST00000505458(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001223"(transcription coactivator binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010744"(positive regulation of macrophage derived foam cell differentiation)|go:"GO:0010884"(positive regulation of lipid storage)|go:"GO:0010956"(negative regulation of calcidiol 1-monooxygenase activity)|go:"GO:0010957"(negative regulation of vitamin D biosynthetic process)|go:"GO:0019899"(enzyme binding)|go:"GO:0032269"(negative regulation of cellular protein metabolic process)|go:"GO:0032375"(negative regulation of cholesterol transport)|go:"GO:0032695"(negative regulation of interleukin-12 production)|go:"GO:0033256"(I-kappaB/NF-kappaB complex)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0035580"(specific granule lumen)|go:"GO:0035994"(response to muscle stretch)|go:"GO:0042802"(identical protein binding)|go:"GO:0042805"(actinin binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071316"(cellular response to nicotine)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071354"(cellular response to interleukin-6)|go:"GO:0071356"(cellular response to tumor necrosis factor)|interpro:IPR000488(Death)|interpro:IPR002110(Ankyrin)|interpro:IPR002909(Cell surface receptor IPT/TIG)|go:"GO:0071359"(cellular response to dsRNA)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR011029(DEATH-like)|interpro:IPR011539(Rel homology)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR020683|interpro:IPR030492|interpro:IPR030503|go:"GO:1900127"(positive regulation of hyaluronan biosynthetic process)|go:"GO:1904385"(cellular response to angiotensin)|interpro:IPR032397|interpro:IPR033926|interpro:IPR036770|interpro:IPR037059|mint:P19838|rcsb pdb:1MDI|rcsb pdb:1MDJ|rcsb pdb:1MDK|rcsb pdb:1NFI|rcsb pdb:1SVC|rcsb pdb:2DBF|rcsb pdb:2O61|rcsb pdb:3GUT|reactome:R-HSA-1169091|reactome:R-HSA-1810476|reactome:R-HSA-193692|reactome:R-HSA-202424|reactome:R-HSA-209560|reactome:R-HSA-2559582|reactome:R-HSA-2871837|go:"GO:2000630"(positive regulation of miRNA metabolic process)|interpro:IPR000451(NF-kappa-B/Rel/dorsal)|reactome:R-HSA-3134963|reactome:R-HSA-3214841|reactome:R-HSA-381340|reactome:R-HSA-445989|refseq:NP_001158884.1|refseq:NP_003989.2|refseq:NP_001306155.1|dip:DIP-106N	refseq:NP_005195.2|refseq:NP_001231063.1|go:"GO:0031295"(T cell costimulation)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017424(Mitogen-activated protein kinase kinase kinase 8)|rcsb pdb:4Y83|rcsb pdb:4Y85|rcsb pdb:5IU2|reactome:R-HSA-389357|reactome:R-HSA-5684264|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007049"(cell cycle)|ensembl:ENSG00000107968(gene)|ensembl:ENST00000263056(transcript)|ensembl:ENST00000375321(transcript)|ensembl:ENST00000542547(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|refseq:NP_001307890.1|refseq:XP_016871196.1|refseq:XP_016871197.1|refseq:XP_016871198.1|refseq:XP_016871199.1|dip:DIP-27534N	-	-	-	comment:"Deletion of the p105 death domain (residues 802-892) or p105 residues 497-538 separately decreased binding to TPL-2, while combined deletion of both these regions in p105 disrupted the interaction."|figure legend:Fig. 5c|comment:When combined with deletion of p105 residues 497-538, the leu841ala mutation disrupts binding to TPL-2.|dataset:IBD - Inflammatory bowel disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2014/10/20	2014/12/23	rogid:Kb83YHl5j5+iZl8v3ERcD8CGNH89606	rogid:jioNJRDtKJU8iwI+dNq4JSEHRoI9606	intact-crc:C5E79DC23BEE319E|rigid:xjbc+xuQURIod6Md2izNQnx2gmU	false	necessary binding region:497-539,802-892|mutation decreasing interaction:841-841|ha tag:n-n	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P41279	uniprotkb:P19838	intact:EBI-354900|uniprotkb:Q14275|uniprotkb:Q5T855|uniprotkb:Q9HC81|uniprotkb:A8K2Q5|uniprotkb:D3DRX1|ensembl:ENSP00000263056|ensembl:ENSP00000364470|ensembl:ENSP00000443610	intact:EBI-300010|ensembl:ENSP00000378297|ensembl:ENSP00000424790|uniprotkb:Q68D84|uniprotkb:Q86V43|uniprotkb:Q8N4X7|uniprotkb:Q9NZC0|uniprotkb:A8K5Y5|uniprotkb:B3KVE8	psi-mi:m3k8_human(display_long)|uniprotkb:MAP3K8(gene name)|psi-mi:MAP3K8(display_short)|uniprotkb:COT(gene name synonym)|uniprotkb:ESTF(gene name synonym)|uniprotkb:Serine/threonine-protein kinase cot(gene name synonym)|uniprotkb:Cancer Osaka thyroid oncogene(gene name synonym)|uniprotkb:Tumor progression locus 2(gene name synonym)|uniprotkb:Proto-oncogene c-Cot(gene name synonym)	psi-mi:nfkb1_human(display_long)|uniprotkb:NFKB1(gene name)|psi-mi:NFKB1(display_short)|uniprotkb:DNA-binding factor KBF1(gene name synonym)|uniprotkb:EBP-1(gene name synonym)|uniprotkb:Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Beinke et al. (2003)	imex:IM-23220|pubmed:12832462	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9868250|imex:IM-23220-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005195.2|refseq:NP_001231063.1|go:"GO:0031295"(T cell costimulation)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017424(Mitogen-activated protein kinase kinase kinase 8)|rcsb pdb:4Y83|rcsb pdb:4Y85|rcsb pdb:5IU2|reactome:R-HSA-389357|reactome:R-HSA-5684264|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007049"(cell cycle)|ensembl:ENSG00000107968(gene)|ensembl:ENST00000263056(transcript)|ensembl:ENST00000375321(transcript)|ensembl:ENST00000542547(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|refseq:NP_001307890.1|refseq:XP_016871196.1|refseq:XP_016871197.1|refseq:XP_016871198.1|refseq:XP_016871199.1|dip:DIP-27534N	reactome:R-HSA-5603029|reactome:R-HSA-5607764|reactome:R-HSA-5621575|reactome:R-HSA-5660668|reactome:R-HSA-5684264|reactome:R-HSA-6798695|reactome:R-HSA-844456|reactome:R-HSA-8853884|reactome:R-HSA-9020702|reactome:R-HSA-933542|reactome:R-HSA-9609690|reactome:R-HSA-9660826|reactome:R-HSA-448706|ensembl:ENSG00000109320(gene)|ensembl:ENST00000394820(transcript)|ensembl:ENST00000505458(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001223"(transcription coactivator binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010744"(positive regulation of macrophage derived foam cell differentiation)|go:"GO:0010884"(positive regulation of lipid storage)|go:"GO:0010956"(negative regulation of calcidiol 1-monooxygenase activity)|go:"GO:0010957"(negative regulation of vitamin D biosynthetic process)|go:"GO:0019899"(enzyme binding)|go:"GO:0032269"(negative regulation of cellular protein metabolic process)|go:"GO:0032375"(negative regulation of cholesterol transport)|go:"GO:0032695"(negative regulation of interleukin-12 production)|go:"GO:0033256"(I-kappaB/NF-kappaB complex)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0035580"(specific granule lumen)|go:"GO:0035994"(response to muscle stretch)|go:"GO:0042802"(identical protein binding)|go:"GO:0042805"(actinin binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071316"(cellular response to nicotine)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071354"(cellular response to interleukin-6)|go:"GO:0071356"(cellular response to tumor necrosis factor)|interpro:IPR000488(Death)|interpro:IPR002110(Ankyrin)|interpro:IPR002909(Cell surface receptor IPT/TIG)|go:"GO:0071359"(cellular response to dsRNA)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR011029(DEATH-like)|interpro:IPR011539(Rel homology)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR020683|interpro:IPR030492|interpro:IPR030503|go:"GO:1900127"(positive regulation of hyaluronan biosynthetic process)|go:"GO:1904385"(cellular response to angiotensin)|interpro:IPR032397|interpro:IPR033926|interpro:IPR036770|interpro:IPR037059|mint:P19838|rcsb pdb:1MDI|rcsb pdb:1MDJ|rcsb pdb:1MDK|rcsb pdb:1NFI|rcsb pdb:1SVC|rcsb pdb:2DBF|rcsb pdb:2O61|rcsb pdb:3GUT|reactome:R-HSA-1169091|reactome:R-HSA-1810476|reactome:R-HSA-193692|reactome:R-HSA-202424|reactome:R-HSA-209560|reactome:R-HSA-2559582|reactome:R-HSA-2871837|go:"GO:2000630"(positive regulation of miRNA metabolic process)|interpro:IPR000451(NF-kappa-B/Rel/dorsal)|reactome:R-HSA-3134963|reactome:R-HSA-3214841|reactome:R-HSA-381340|reactome:R-HSA-445989|refseq:NP_001158884.1|refseq:NP_003989.2|refseq:NP_001306155.1|dip:DIP-106N	-	-	-	figure legend:Fig. 2c|dataset:IBD - Inflammatory bowel disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/10/20	2014/10/20	rogid:jioNJRDtKJU8iwI+dNq4JSEHRoI9606	rogid:Kb83YHl5j5+iZl8v3ERcD8CGNH89606	intact-crc:66F4C57FBE67D3E9|rigid:xjbc+xuQURIod6Md2izNQnx2gmU	false	35s radiolabel:?-?	glutathione s tranferase tag:n-n|sufficient binding region:808-892(IPR000488)	-	-	psi-mi:"MI:0833"(autoradiography)	psi-mi:"MI:0833"(autoradiography)
uniprotkb:P41279	uniprotkb:P19838	intact:EBI-354900|uniprotkb:Q14275|uniprotkb:Q5T855|uniprotkb:Q9HC81|uniprotkb:A8K2Q5|uniprotkb:D3DRX1|ensembl:ENSP00000263056|ensembl:ENSP00000364470|ensembl:ENSP00000443610	intact:EBI-300010|ensembl:ENSP00000378297|ensembl:ENSP00000424790|uniprotkb:Q68D84|uniprotkb:Q86V43|uniprotkb:Q8N4X7|uniprotkb:Q9NZC0|uniprotkb:A8K5Y5|uniprotkb:B3KVE8	psi-mi:m3k8_human(display_long)|uniprotkb:MAP3K8(gene name)|psi-mi:MAP3K8(display_short)|uniprotkb:COT(gene name synonym)|uniprotkb:ESTF(gene name synonym)|uniprotkb:Serine/threonine-protein kinase cot(gene name synonym)|uniprotkb:Cancer Osaka thyroid oncogene(gene name synonym)|uniprotkb:Tumor progression locus 2(gene name synonym)|uniprotkb:Proto-oncogene c-Cot(gene name synonym)	psi-mi:nfkb1_human(display_long)|uniprotkb:NFKB1(gene name)|psi-mi:NFKB1(display_short)|uniprotkb:DNA-binding factor KBF1(gene name synonym)|uniprotkb:EBP-1(gene name synonym)|uniprotkb:Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Beinke et al. (2003)	imex:IM-23220|pubmed:12832462	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9868275|imex:IM-23220-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005195.2|refseq:NP_001231063.1|go:"GO:0031295"(T cell costimulation)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017424(Mitogen-activated protein kinase kinase kinase 8)|rcsb pdb:4Y83|rcsb pdb:4Y85|rcsb pdb:5IU2|reactome:R-HSA-389357|reactome:R-HSA-5684264|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007049"(cell cycle)|ensembl:ENSG00000107968(gene)|ensembl:ENST00000263056(transcript)|ensembl:ENST00000375321(transcript)|ensembl:ENST00000542547(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|refseq:NP_001307890.1|refseq:XP_016871196.1|refseq:XP_016871197.1|refseq:XP_016871198.1|refseq:XP_016871199.1|dip:DIP-27534N	reactome:R-HSA-5603029|reactome:R-HSA-5607764|reactome:R-HSA-5621575|reactome:R-HSA-5660668|reactome:R-HSA-5684264|reactome:R-HSA-6798695|reactome:R-HSA-844456|reactome:R-HSA-8853884|reactome:R-HSA-9020702|reactome:R-HSA-933542|reactome:R-HSA-9609690|reactome:R-HSA-9660826|reactome:R-HSA-448706|ensembl:ENSG00000109320(gene)|ensembl:ENST00000394820(transcript)|ensembl:ENST00000505458(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001223"(transcription coactivator binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010744"(positive regulation of macrophage derived foam cell differentiation)|go:"GO:0010884"(positive regulation of lipid storage)|go:"GO:0010956"(negative regulation of calcidiol 1-monooxygenase activity)|go:"GO:0010957"(negative regulation of vitamin D biosynthetic process)|go:"GO:0019899"(enzyme binding)|go:"GO:0032269"(negative regulation of cellular protein metabolic process)|go:"GO:0032375"(negative regulation of cholesterol transport)|go:"GO:0032695"(negative regulation of interleukin-12 production)|go:"GO:0033256"(I-kappaB/NF-kappaB complex)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0035580"(specific granule lumen)|go:"GO:0035994"(response to muscle stretch)|go:"GO:0042802"(identical protein binding)|go:"GO:0042805"(actinin binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071316"(cellular response to nicotine)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071354"(cellular response to interleukin-6)|go:"GO:0071356"(cellular response to tumor necrosis factor)|interpro:IPR000488(Death)|interpro:IPR002110(Ankyrin)|interpro:IPR002909(Cell surface receptor IPT/TIG)|go:"GO:0071359"(cellular response to dsRNA)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR011029(DEATH-like)|interpro:IPR011539(Rel homology)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR020683|interpro:IPR030492|interpro:IPR030503|go:"GO:1900127"(positive regulation of hyaluronan biosynthetic process)|go:"GO:1904385"(cellular response to angiotensin)|interpro:IPR032397|interpro:IPR033926|interpro:IPR036770|interpro:IPR037059|mint:P19838|rcsb pdb:1MDI|rcsb pdb:1MDJ|rcsb pdb:1MDK|rcsb pdb:1NFI|rcsb pdb:1SVC|rcsb pdb:2DBF|rcsb pdb:2O61|rcsb pdb:3GUT|reactome:R-HSA-1169091|reactome:R-HSA-1810476|reactome:R-HSA-193692|reactome:R-HSA-202424|reactome:R-HSA-209560|reactome:R-HSA-2559582|reactome:R-HSA-2871837|go:"GO:2000630"(positive regulation of miRNA metabolic process)|interpro:IPR000451(NF-kappa-B/Rel/dorsal)|reactome:R-HSA-3134963|reactome:R-HSA-3214841|reactome:R-HSA-381340|reactome:R-HSA-445989|refseq:NP_001158884.1|refseq:NP_003989.2|refseq:NP_001306155.1|dip:DIP-106N	-	-	-	figure legend:Fig. 3c, 3d|kinetic_conditions:Temp = 25C|kinetics:"The C-terminal fragment of TPL-2 (residues 398-467) bound to the p105 construct (residues 497-968) with Kd = 138 x 10E-9 molar, to p105 (residues 497-805) with Kd = 123 x 10E-9 molar and to p105 (residues 497-782) with Kd = 88 X 10E-9 molar. No binding to p105 (residues 540-801) was detected."|dataset:IBD - Inflammatory bowel disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:138.0x10^-9(molar)	2014/10/20	2015/01/08	rogid:jioNJRDtKJU8iwI+dNq4JSEHRoI9606	rogid:Kb83YHl5j5+iZl8v3ERcD8CGNH89606	intact-crc:866E6389B3276390|rigid:xjbc+xuQURIod6Md2izNQnx2gmU	false	biotin tag:n-n|sufficient binding region:398-467	necessary binding region:497-539	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P41279	uniprotkb:P19838	intact:EBI-354900|uniprotkb:Q14275|uniprotkb:Q5T855|uniprotkb:Q9HC81|uniprotkb:A8K2Q5|uniprotkb:D3DRX1|ensembl:ENSP00000263056|ensembl:ENSP00000364470|ensembl:ENSP00000443610	intact:EBI-300010|ensembl:ENSP00000378297|ensembl:ENSP00000424790|uniprotkb:Q68D84|uniprotkb:Q86V43|uniprotkb:Q8N4X7|uniprotkb:Q9NZC0|uniprotkb:A8K5Y5|uniprotkb:B3KVE8	psi-mi:m3k8_human(display_long)|uniprotkb:MAP3K8(gene name)|psi-mi:MAP3K8(display_short)|uniprotkb:COT(gene name synonym)|uniprotkb:ESTF(gene name synonym)|uniprotkb:Serine/threonine-protein kinase cot(gene name synonym)|uniprotkb:Cancer Osaka thyroid oncogene(gene name synonym)|uniprotkb:Tumor progression locus 2(gene name synonym)|uniprotkb:Proto-oncogene c-Cot(gene name synonym)	psi-mi:nfkb1_human(display_long)|uniprotkb:NFKB1(gene name)|psi-mi:NFKB1(display_short)|uniprotkb:DNA-binding factor KBF1(gene name synonym)|uniprotkb:EBP-1(gene name synonym)|uniprotkb:Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1(gene name synonym)	psi-mi:"MI:0065"(isothermal titration calorimetry)	Beinke et al. (2003)	imex:IM-23220|pubmed:12832462	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9868310|imex:IM-23220-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005195.2|refseq:NP_001231063.1|go:"GO:0031295"(T cell costimulation)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017424(Mitogen-activated protein kinase kinase kinase 8)|rcsb pdb:4Y83|rcsb pdb:4Y85|rcsb pdb:5IU2|reactome:R-HSA-389357|reactome:R-HSA-5684264|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007049"(cell cycle)|ensembl:ENSG00000107968(gene)|ensembl:ENST00000263056(transcript)|ensembl:ENST00000375321(transcript)|ensembl:ENST00000542547(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|refseq:NP_001307890.1|refseq:XP_016871196.1|refseq:XP_016871197.1|refseq:XP_016871198.1|refseq:XP_016871199.1|dip:DIP-27534N	reactome:R-HSA-5603029|reactome:R-HSA-5607764|reactome:R-HSA-5621575|reactome:R-HSA-5660668|reactome:R-HSA-5684264|reactome:R-HSA-6798695|reactome:R-HSA-844456|reactome:R-HSA-8853884|reactome:R-HSA-9020702|reactome:R-HSA-933542|reactome:R-HSA-9609690|reactome:R-HSA-9660826|reactome:R-HSA-448706|ensembl:ENSG00000109320(gene)|ensembl:ENST00000394820(transcript)|ensembl:ENST00000505458(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001223"(transcription coactivator binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010744"(positive regulation of macrophage derived foam cell differentiation)|go:"GO:0010884"(positive regulation of lipid storage)|go:"GO:0010956"(negative regulation of calcidiol 1-monooxygenase activity)|go:"GO:0010957"(negative regulation of vitamin D biosynthetic process)|go:"GO:0019899"(enzyme binding)|go:"GO:0032269"(negative regulation of cellular protein metabolic process)|go:"GO:0032375"(negative regulation of cholesterol transport)|go:"GO:0032695"(negative regulation of interleukin-12 production)|go:"GO:0033256"(I-kappaB/NF-kappaB complex)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0035580"(specific granule lumen)|go:"GO:0035994"(response to muscle stretch)|go:"GO:0042802"(identical protein binding)|go:"GO:0042805"(actinin binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071316"(cellular response to nicotine)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071354"(cellular response to interleukin-6)|go:"GO:0071356"(cellular response to tumor necrosis factor)|interpro:IPR000488(Death)|interpro:IPR002110(Ankyrin)|interpro:IPR002909(Cell surface receptor IPT/TIG)|go:"GO:0071359"(cellular response to dsRNA)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR011029(DEATH-like)|interpro:IPR011539(Rel homology)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR020683|interpro:IPR030492|interpro:IPR030503|go:"GO:1900127"(positive regulation of hyaluronan biosynthetic process)|go:"GO:1904385"(cellular response to angiotensin)|interpro:IPR032397|interpro:IPR033926|interpro:IPR036770|interpro:IPR037059|mint:P19838|rcsb pdb:1MDI|rcsb pdb:1MDJ|rcsb pdb:1MDK|rcsb pdb:1NFI|rcsb pdb:1SVC|rcsb pdb:2DBF|rcsb pdb:2O61|rcsb pdb:3GUT|reactome:R-HSA-1169091|reactome:R-HSA-1810476|reactome:R-HSA-193692|reactome:R-HSA-202424|reactome:R-HSA-209560|reactome:R-HSA-2559582|reactome:R-HSA-2871837|go:"GO:2000630"(positive regulation of miRNA metabolic process)|interpro:IPR000451(NF-kappa-B/Rel/dorsal)|reactome:R-HSA-3134963|reactome:R-HSA-3214841|reactome:R-HSA-381340|reactome:R-HSA-445989|refseq:NP_001158884.1|refseq:NP_003989.2|refseq:NP_001306155.1|dip:DIP-106N	-	-	-	causality statement:P19838 decreases degradation at protein level of P41279|causality statement:P19838 decreases activity of P41279|causality statement:P19838 decreases binding of P41279 to Q02750|figure legend:Fig. 4a|kinetic_conditions:Temp = 20C|kinetics:"The Kd of 58 x 10E-9 molar was determined for binding of the C-terminal region of TPL-2 (residues 398-467) to p105 construct (residues 497-805). TPL-2 (residues 398-467) bound to p105 (residues 497-757) with Kd = 64 x 10E-9 molar. No binding was detected to p105 (residues 540-801)."|dataset:IBD - Inflammatory bowel disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:58.0x10^-9(molar)	2014/10/20	2014/12/23	rogid:jioNJRDtKJU8iwI+dNq4JSEHRoI9606	rogid:Kb83YHl5j5+iZl8v3ERcD8CGNH89606	intact-crc:6B37DCCE178CC387|rigid:xjbc+xuQURIod6Md2izNQnx2gmU	false	biotin tag:n-n|sufficient binding region:398-467	necessary binding region:497-539	1	2	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P41279	uniprotkb:P19838	intact:EBI-354900|uniprotkb:Q14275|uniprotkb:Q5T855|uniprotkb:Q9HC81|uniprotkb:A8K2Q5|uniprotkb:D3DRX1|ensembl:ENSP00000263056|ensembl:ENSP00000364470|ensembl:ENSP00000443610	intact:EBI-300010|ensembl:ENSP00000378297|ensembl:ENSP00000424790|uniprotkb:Q68D84|uniprotkb:Q86V43|uniprotkb:Q8N4X7|uniprotkb:Q9NZC0|uniprotkb:A8K5Y5|uniprotkb:B3KVE8	psi-mi:m3k8_human(display_long)|uniprotkb:MAP3K8(gene name)|psi-mi:MAP3K8(display_short)|uniprotkb:COT(gene name synonym)|uniprotkb:ESTF(gene name synonym)|uniprotkb:Serine/threonine-protein kinase cot(gene name synonym)|uniprotkb:Cancer Osaka thyroid oncogene(gene name synonym)|uniprotkb:Tumor progression locus 2(gene name synonym)|uniprotkb:Proto-oncogene c-Cot(gene name synonym)	psi-mi:nfkb1_human(display_long)|uniprotkb:NFKB1(gene name)|psi-mi:NFKB1(display_short)|uniprotkb:DNA-binding factor KBF1(gene name synonym)|uniprotkb:EBP-1(gene name synonym)|uniprotkb:Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Beinke et al. (2003)	imex:IM-23220|pubmed:12832462	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9868334|imex:IM-23220-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005195.2|refseq:NP_001231063.1|go:"GO:0031295"(T cell costimulation)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017424(Mitogen-activated protein kinase kinase kinase 8)|rcsb pdb:4Y83|rcsb pdb:4Y85|rcsb pdb:5IU2|reactome:R-HSA-389357|reactome:R-HSA-5684264|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007049"(cell cycle)|ensembl:ENSG00000107968(gene)|ensembl:ENST00000263056(transcript)|ensembl:ENST00000375321(transcript)|ensembl:ENST00000542547(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|refseq:NP_001307890.1|refseq:XP_016871196.1|refseq:XP_016871197.1|refseq:XP_016871198.1|refseq:XP_016871199.1|dip:DIP-27534N	reactome:R-HSA-5603029|reactome:R-HSA-5607764|reactome:R-HSA-5621575|reactome:R-HSA-5660668|reactome:R-HSA-5684264|reactome:R-HSA-6798695|reactome:R-HSA-844456|reactome:R-HSA-8853884|reactome:R-HSA-9020702|reactome:R-HSA-933542|reactome:R-HSA-9609690|reactome:R-HSA-9660826|reactome:R-HSA-448706|ensembl:ENSG00000109320(gene)|ensembl:ENST00000394820(transcript)|ensembl:ENST00000505458(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001223"(transcription coactivator binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010744"(positive regulation of macrophage derived foam cell differentiation)|go:"GO:0010884"(positive regulation of lipid storage)|go:"GO:0010956"(negative regulation of calcidiol 1-monooxygenase activity)|go:"GO:0010957"(negative regulation of vitamin D biosynthetic process)|go:"GO:0019899"(enzyme binding)|go:"GO:0032269"(negative regulation of cellular protein metabolic process)|go:"GO:0032375"(negative regulation of cholesterol transport)|go:"GO:0032695"(negative regulation of interleukin-12 production)|go:"GO:0033256"(I-kappaB/NF-kappaB complex)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0035580"(specific granule lumen)|go:"GO:0035994"(response to muscle stretch)|go:"GO:0042802"(identical protein binding)|go:"GO:0042805"(actinin binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071316"(cellular response to nicotine)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071354"(cellular response to interleukin-6)|go:"GO:0071356"(cellular response to tumor necrosis factor)|interpro:IPR000488(Death)|interpro:IPR002110(Ankyrin)|interpro:IPR002909(Cell surface receptor IPT/TIG)|go:"GO:0071359"(cellular response to dsRNA)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR011029(DEATH-like)|interpro:IPR011539(Rel homology)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR020683|interpro:IPR030492|interpro:IPR030503|go:"GO:1900127"(positive regulation of hyaluronan biosynthetic process)|go:"GO:1904385"(cellular response to angiotensin)|interpro:IPR032397|interpro:IPR033926|interpro:IPR036770|interpro:IPR037059|mint:P19838|rcsb pdb:1MDI|rcsb pdb:1MDJ|rcsb pdb:1MDK|rcsb pdb:1NFI|rcsb pdb:1SVC|rcsb pdb:2DBF|rcsb pdb:2O61|rcsb pdb:3GUT|reactome:R-HSA-1169091|reactome:R-HSA-1810476|reactome:R-HSA-193692|reactome:R-HSA-202424|reactome:R-HSA-209560|reactome:R-HSA-2559582|reactome:R-HSA-2871837|go:"GO:2000630"(positive regulation of miRNA metabolic process)|interpro:IPR000451(NF-kappa-B/Rel/dorsal)|reactome:R-HSA-3134963|reactome:R-HSA-3214841|reactome:R-HSA-381340|reactome:R-HSA-445989|refseq:NP_001158884.1|refseq:NP_003989.2|refseq:NP_001306155.1|dip:DIP-106N	-	-	-	figure legend:Fig. 5b|dataset:IBD - Inflammatory bowel disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/10/20	2014/10/20	rogid:jioNJRDtKJU8iwI+dNq4JSEHRoI9606	rogid:Kb83YHl5j5+iZl8v3ERcD8CGNH89606	intact-crc:FAD55016F27245CF|rigid:xjbc+xuQURIod6Md2izNQnx2gmU	false	sufficient binding region:398-467|biotin tag:n-n	ha tag:n-n|necessary binding region:497-538	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P41279	uniprotkb:P19838	intact:EBI-354900|uniprotkb:Q14275|uniprotkb:Q5T855|uniprotkb:Q9HC81|uniprotkb:A8K2Q5|uniprotkb:D3DRX1|ensembl:ENSP00000263056|ensembl:ENSP00000364470|ensembl:ENSP00000443610	intact:EBI-300010|ensembl:ENSP00000378297|ensembl:ENSP00000424790|uniprotkb:Q68D84|uniprotkb:Q86V43|uniprotkb:Q8N4X7|uniprotkb:Q9NZC0|uniprotkb:A8K5Y5|uniprotkb:B3KVE8	psi-mi:m3k8_human(display_long)|uniprotkb:MAP3K8(gene name)|psi-mi:MAP3K8(display_short)|uniprotkb:COT(gene name synonym)|uniprotkb:ESTF(gene name synonym)|uniprotkb:Serine/threonine-protein kinase cot(gene name synonym)|uniprotkb:Cancer Osaka thyroid oncogene(gene name synonym)|uniprotkb:Tumor progression locus 2(gene name synonym)|uniprotkb:Proto-oncogene c-Cot(gene name synonym)	psi-mi:nfkb1_human(display_long)|uniprotkb:NFKB1(gene name)|psi-mi:NFKB1(display_short)|uniprotkb:DNA-binding factor KBF1(gene name synonym)|uniprotkb:EBP-1(gene name synonym)|uniprotkb:Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1(gene name synonym)	psi-mi:"MI:0605"(enzymatic footprinting)	Beinke et al. (2003)	imex:IM-23220|pubmed:12832462	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-9984800|imex:IM-23220-8	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005195.2|refseq:NP_001231063.1|go:"GO:0031295"(T cell costimulation)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017424(Mitogen-activated protein kinase kinase kinase 8)|rcsb pdb:4Y83|rcsb pdb:4Y85|rcsb pdb:5IU2|reactome:R-HSA-389357|reactome:R-HSA-5684264|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007049"(cell cycle)|ensembl:ENSG00000107968(gene)|ensembl:ENST00000263056(transcript)|ensembl:ENST00000375321(transcript)|ensembl:ENST00000542547(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|refseq:NP_001307890.1|refseq:XP_016871196.1|refseq:XP_016871197.1|refseq:XP_016871198.1|refseq:XP_016871199.1|dip:DIP-27534N	reactome:R-HSA-5603029|reactome:R-HSA-5607764|reactome:R-HSA-5621575|reactome:R-HSA-5660668|reactome:R-HSA-5684264|reactome:R-HSA-6798695|reactome:R-HSA-844456|reactome:R-HSA-8853884|reactome:R-HSA-9020702|reactome:R-HSA-933542|reactome:R-HSA-9609690|reactome:R-HSA-9660826|reactome:R-HSA-448706|ensembl:ENSG00000109320(gene)|ensembl:ENST00000394820(transcript)|ensembl:ENST00000505458(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001223"(transcription coactivator binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010744"(positive regulation of macrophage derived foam cell differentiation)|go:"GO:0010884"(positive regulation of lipid storage)|go:"GO:0010956"(negative regulation of calcidiol 1-monooxygenase activity)|go:"GO:0010957"(negative regulation of vitamin D biosynthetic process)|go:"GO:0019899"(enzyme binding)|go:"GO:0032269"(negative regulation of cellular protein metabolic process)|go:"GO:0032375"(negative regulation of cholesterol transport)|go:"GO:0032695"(negative regulation of interleukin-12 production)|go:"GO:0033256"(I-kappaB/NF-kappaB complex)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0035580"(specific granule lumen)|go:"GO:0035994"(response to muscle stretch)|go:"GO:0042802"(identical protein binding)|go:"GO:0042805"(actinin binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071316"(cellular response to nicotine)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071354"(cellular response to interleukin-6)|go:"GO:0071356"(cellular response to tumor necrosis factor)|interpro:IPR000488(Death)|interpro:IPR002110(Ankyrin)|interpro:IPR002909(Cell surface receptor IPT/TIG)|go:"GO:0071359"(cellular response to dsRNA)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR011029(DEATH-like)|interpro:IPR011539(Rel homology)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR020683|interpro:IPR030492|interpro:IPR030503|go:"GO:1900127"(positive regulation of hyaluronan biosynthetic process)|go:"GO:1904385"(cellular response to angiotensin)|interpro:IPR032397|interpro:IPR033926|interpro:IPR036770|interpro:IPR037059|mint:P19838|rcsb pdb:1MDI|rcsb pdb:1MDJ|rcsb pdb:1MDK|rcsb pdb:1NFI|rcsb pdb:1SVC|rcsb pdb:2DBF|rcsb pdb:2O61|rcsb pdb:3GUT|reactome:R-HSA-1169091|reactome:R-HSA-1810476|reactome:R-HSA-193692|reactome:R-HSA-202424|reactome:R-HSA-209560|reactome:R-HSA-2559582|reactome:R-HSA-2871837|go:"GO:2000630"(positive regulation of miRNA metabolic process)|interpro:IPR000451(NF-kappa-B/Rel/dorsal)|reactome:R-HSA-3134963|reactome:R-HSA-3214841|reactome:R-HSA-381340|reactome:R-HSA-445989|refseq:NP_001158884.1|refseq:NP_003989.2|refseq:NP_001306155.1|dip:DIP-106N	-	-	-	figure legend:Fig. 3b|dataset:IBD - Inflammatory bowel disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/10/20	2014/11/24	rogid:jioNJRDtKJU8iwI+dNq4JSEHRoI9606	rogid:Kb83YHl5j5+iZl8v3ERcD8CGNH89606	intact-crc:BDDE2352AC7897BF|rigid:xjbc+xuQURIod6Md2izNQnx2gmU	false	biotin tag:n-n|binding-associated region:398-467	-	-	-	psi-mi:"MI:0039"(edman degradation)	psi-mi:"MI:0039"(edman degradation)
uniprotkb:P19838	uniprotkb:P19838	intact:EBI-300010|ensembl:ENSP00000378297|ensembl:ENSP00000424790|uniprotkb:Q68D84|uniprotkb:Q86V43|uniprotkb:Q8N4X7|uniprotkb:Q9NZC0|uniprotkb:A8K5Y5|uniprotkb:B3KVE8	intact:EBI-300010|ensembl:ENSP00000378297|ensembl:ENSP00000424790|uniprotkb:Q68D84|uniprotkb:Q86V43|uniprotkb:Q8N4X7|uniprotkb:Q9NZC0|uniprotkb:A8K5Y5|uniprotkb:B3KVE8	psi-mi:nfkb1_human(display_long)|uniprotkb:NFKB1(gene name)|psi-mi:NFKB1(display_short)|uniprotkb:DNA-binding factor KBF1(gene name synonym)|uniprotkb:EBP-1(gene name synonym)|uniprotkb:Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1(gene name synonym)	psi-mi:nfkb1_human(display_long)|uniprotkb:NFKB1(gene name)|psi-mi:NFKB1(display_short)|uniprotkb:DNA-binding factor KBF1(gene name synonym)|uniprotkb:EBP-1(gene name synonym)|uniprotkb:Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1(gene name synonym)	psi-mi:"MI:0027"(cosedimentation)	Beinke et al. (2003)	imex:IM-23220|pubmed:12832462	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10049034|imex:IM-23220-9	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	reactome:R-HSA-5603029|reactome:R-HSA-5607764|reactome:R-HSA-5621575|reactome:R-HSA-5660668|reactome:R-HSA-5684264|reactome:R-HSA-6798695|reactome:R-HSA-844456|reactome:R-HSA-8853884|reactome:R-HSA-9020702|reactome:R-HSA-933542|reactome:R-HSA-9609690|reactome:R-HSA-9660826|reactome:R-HSA-448706|ensembl:ENSG00000109320(gene)|ensembl:ENST00000394820(transcript)|ensembl:ENST00000505458(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001223"(transcription coactivator binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010744"(positive regulation of macrophage derived foam cell differentiation)|go:"GO:0010884"(positive regulation of lipid storage)|go:"GO:0010956"(negative regulation of calcidiol 1-monooxygenase activity)|go:"GO:0010957"(negative regulation of vitamin D biosynthetic process)|go:"GO:0019899"(enzyme binding)|go:"GO:0032269"(negative regulation of cellular protein metabolic process)|go:"GO:0032375"(negative regulation of cholesterol transport)|go:"GO:0032695"(negative regulation of interleukin-12 production)|go:"GO:0033256"(I-kappaB/NF-kappaB complex)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0035580"(specific granule lumen)|go:"GO:0035994"(response to muscle stretch)|go:"GO:0042802"(identical protein binding)|go:"GO:0042805"(actinin binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071316"(cellular response to nicotine)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071354"(cellular response to interleukin-6)|go:"GO:0071356"(cellular response to tumor necrosis factor)|interpro:IPR000488(Death)|interpro:IPR002110(Ankyrin)|interpro:IPR002909(Cell surface receptor IPT/TIG)|go:"GO:0071359"(cellular response to dsRNA)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR011029(DEATH-like)|interpro:IPR011539(Rel homology)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR020683|interpro:IPR030492|interpro:IPR030503|go:"GO:1900127"(positive regulation of hyaluronan biosynthetic process)|go:"GO:1904385"(cellular response to angiotensin)|interpro:IPR032397|interpro:IPR033926|interpro:IPR036770|interpro:IPR037059|mint:P19838|rcsb pdb:1MDI|rcsb pdb:1MDJ|rcsb pdb:1MDK|rcsb pdb:1NFI|rcsb pdb:1SVC|rcsb pdb:2DBF|rcsb pdb:2O61|rcsb pdb:3GUT|reactome:R-HSA-1169091|reactome:R-HSA-1810476|reactome:R-HSA-193692|reactome:R-HSA-202424|reactome:R-HSA-209560|reactome:R-HSA-2559582|reactome:R-HSA-2871837|go:"GO:2000630"(positive regulation of miRNA metabolic process)|interpro:IPR000451(NF-kappa-B/Rel/dorsal)|reactome:R-HSA-3134963|reactome:R-HSA-3214841|reactome:R-HSA-381340|reactome:R-HSA-445989|refseq:NP_001158884.1|refseq:NP_003989.2|refseq:NP_001306155.1|dip:DIP-106N	reactome:R-HSA-5603029|reactome:R-HSA-5607764|reactome:R-HSA-5621575|reactome:R-HSA-5660668|reactome:R-HSA-5684264|reactome:R-HSA-6798695|reactome:R-HSA-844456|reactome:R-HSA-8853884|reactome:R-HSA-9020702|reactome:R-HSA-933542|reactome:R-HSA-9609690|reactome:R-HSA-9660826|reactome:R-HSA-448706|ensembl:ENSG00000109320(gene)|ensembl:ENST00000394820(transcript)|ensembl:ENST00000505458(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001223"(transcription coactivator binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010744"(positive regulation of macrophage derived foam cell differentiation)|go:"GO:0010884"(positive regulation of lipid storage)|go:"GO:0010956"(negative regulation of calcidiol 1-monooxygenase activity)|go:"GO:0010957"(negative regulation of vitamin D biosynthetic process)|go:"GO:0019899"(enzyme binding)|go:"GO:0032269"(negative regulation of cellular protein metabolic process)|go:"GO:0032375"(negative regulation of cholesterol transport)|go:"GO:0032695"(negative regulation of interleukin-12 production)|go:"GO:0033256"(I-kappaB/NF-kappaB complex)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0035580"(specific granule lumen)|go:"GO:0035994"(response to muscle stretch)|go:"GO:0042802"(identical protein binding)|go:"GO:0042805"(actinin binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071316"(cellular response to nicotine)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071354"(cellular response to interleukin-6)|go:"GO:0071356"(cellular response to tumor necrosis factor)|interpro:IPR000488(Death)|interpro:IPR002110(Ankyrin)|interpro:IPR002909(Cell surface receptor IPT/TIG)|go:"GO:0071359"(cellular response to dsRNA)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR011029(DEATH-like)|interpro:IPR011539(Rel homology)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR020683|interpro:IPR030492|interpro:IPR030503|go:"GO:1900127"(positive regulation of hyaluronan biosynthetic process)|go:"GO:1904385"(cellular response to angiotensin)|interpro:IPR032397|interpro:IPR033926|interpro:IPR036770|interpro:IPR037059|mint:P19838|rcsb pdb:1MDI|rcsb pdb:1MDJ|rcsb pdb:1MDK|rcsb pdb:1NFI|rcsb pdb:1SVC|rcsb pdb:2DBF|rcsb pdb:2O61|rcsb pdb:3GUT|reactome:R-HSA-1169091|reactome:R-HSA-1810476|reactome:R-HSA-193692|reactome:R-HSA-202424|reactome:R-HSA-209560|reactome:R-HSA-2559582|reactome:R-HSA-2871837|go:"GO:2000630"(positive regulation of miRNA metabolic process)|interpro:IPR000451(NF-kappa-B/Rel/dorsal)|reactome:R-HSA-3134963|reactome:R-HSA-3214841|reactome:R-HSA-381340|reactome:R-HSA-445989|refseq:NP_001158884.1|refseq:NP_003989.2|refseq:NP_001306155.1|dip:DIP-106N	-	-	-	figure legend:Fig. 4b|dataset:IBD - Inflammatory bowel disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/10/20	2014/12/23	rogid:Kb83YHl5j5+iZl8v3ERcD8CGNH89606	rogid:Kb83YHl5j5+iZl8v3ERcD8CGNH89606	intact-crc:B67CD55FCE90F0CF|rigid:9v24Vl1kg27RoteXhlM00QUPDxc	false	necessary binding region:497-539	necessary binding region:497-539	1	1	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q02750	uniprotkb:P41279	intact:EBI-492564|ensembl:ENSP00000302486	intact:EBI-354900|uniprotkb:Q14275|uniprotkb:Q5T855|uniprotkb:Q9HC81|uniprotkb:A8K2Q5|uniprotkb:D3DRX1|ensembl:ENSP00000263056|ensembl:ENSP00000364470|ensembl:ENSP00000443610	psi-mi:mp2k1_human(display_long)|uniprotkb:ERK activator kinase 1(gene name synonym)|uniprotkb:MAPK/ERK kinase 1(gene name synonym)|uniprotkb:MAP2K1(gene name)|psi-mi:MAP2K1(display_short)|uniprotkb:MEK1(gene name synonym)|uniprotkb:PRKMK1(gene name synonym)	psi-mi:m3k8_human(display_long)|uniprotkb:MAP3K8(gene name)|psi-mi:MAP3K8(display_short)|uniprotkb:COT(gene name synonym)|uniprotkb:ESTF(gene name synonym)|uniprotkb:Serine/threonine-protein kinase cot(gene name synonym)|uniprotkb:Cancer Osaka thyroid oncogene(gene name synonym)|uniprotkb:Tumor progression locus 2(gene name synonym)|uniprotkb:Proto-oncogene c-Cot(gene name synonym)	psi-mi:"MI:0096"(pull down)	Beinke et al. (2003)	imex:IM-23220|pubmed:12832462	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10049120|imex:IM-23220-10	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002746.1|refseq:XP_016877900.1|dip:DIP-201N|ensembl:ENSG00000169032(gene)|ensembl:ENST00000307102(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004712"(protein serine/threonine/tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005078"(MAP-kinase scaffold activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006935"(chemotaxis)|go:"GO:0007165"(signal transduction)|go:"GO:0007507"(heart development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0021697"(cerebellar cortex formation)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0030878"(thyroid gland development)|go:"GO:0032872"(regulation of stress-activated MAPK cascade)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048538"(thymus development)|go:"GO:0048679"(regulation of axon regeneration)|go:"GO:0048870"(cell motility)|go:"GO:0050772"(positive regulation of axonogenesis)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060020"(Bergmann glial cell differentiation)|go:"GO:0060324"(face development)|go:"GO:0060440"(trachea formation)|go:"GO:0060502"(epithelial cell proliferation involved in lung morphogenesis)|go:"GO:0060674"(placenta blood vessel development)|go:"GO:0060711"(labyrinthine layer development)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0090170"(regulation of Golgi inheritance)|go:"GO:0090398"(cellular senescence)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1903800"(positive regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:2000641"(regulation of early endosome to late endosome transport)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:Q02750|rcsb pdb:1S9J|rcsb pdb:2P55|rcsb pdb:3DV3|rcsb pdb:3DY7|rcsb pdb:3E8N|rcsb pdb:3EQB|rcsb pdb:3EQC|rcsb pdb:3EQD|rcsb pdb:3EQF|rcsb pdb:3EQG|rcsb pdb:3EQH|rcsb pdb:3EQI|rcsb pdb:3MBL|rcsb pdb:3ORN|rcsb pdb:3OS3|rcsb pdb:3PP1|rcsb pdb:3SLS|rcsb pdb:3V01|rcsb pdb:3V04|rcsb pdb:3VVH|rcsb pdb:3W8Q|rcsb pdb:3WIG|rcsb pdb:3ZLS|rcsb pdb:3ZLW|rcsb pdb:3ZLX|rcsb pdb:3ZLY|rcsb pdb:3ZM4|rcsb pdb:4AN2|rcsb pdb:4AN3|rcsb pdb:4AN9|rcsb pdb:4ANB|rcsb pdb:4ARK|rcsb pdb:4LMN|rcsb pdb:4MNE|rcsb pdb:4U7Z|rcsb pdb:4U80|rcsb pdb:4U81|rcsb pdb:5EYM|rcsb pdb:5HZE|rcsb pdb:5YT3|rcsb pdb:6NYB|rcsb pdb:6PP9|rcsb pdb:6Q0J|rcsb pdb:6Q0T|rcsb pdb:6U2G|rcsb pdb:6V2W|rcsb pdb:6X2P|rcsb pdb:6X2S|rcsb pdb:6X2X|rcsb pdb:7B3M|rcsb pdb:7B7R|rcsb pdb:7B94|rcsb pdb:7B9L|rcsb pdb:7M0T|rcsb pdb:7M0U|rcsb pdb:7M0V|rcsb pdb:7M0W|rcsb pdb:7M0X|rcsb pdb:7M0Y|rcsb pdb:7M0Z|reactome:R-HSA-110056|reactome:R-HSA-170968|reactome:R-HSA-445144|reactome:R-HSA-5210891|reactome:R-HSA-5673000|reactome:R-HSA-5674135|reactome:R-HSA-5674499|reactome:R-HSA-5684264|reactome:R-HSA-6802946|reactome:R-HSA-6802948|reactome:R-HSA-6802952|reactome:R-HSA-6802955|reactome:R-HSA-9649948|reactome:R-HSA-9652169|reactome:R-HSA-9656223|rcsb pdb:5BX0	refseq:NP_005195.2|refseq:NP_001231063.1|go:"GO:0031295"(T cell costimulation)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017424(Mitogen-activated protein kinase kinase kinase 8)|rcsb pdb:4Y83|rcsb pdb:4Y85|rcsb pdb:5IU2|reactome:R-HSA-389357|reactome:R-HSA-5684264|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007049"(cell cycle)|ensembl:ENSG00000107968(gene)|ensembl:ENST00000263056(transcript)|ensembl:ENST00000375321(transcript)|ensembl:ENST00000542547(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|refseq:NP_001307890.1|refseq:XP_016871196.1|refseq:XP_016871197.1|refseq:XP_016871198.1|refseq:XP_016871199.1|dip:DIP-27534N	-	-	-	figure legend:Fig. 9b, 9c|inhibition:P19838|dataset:IBD - Inflammatory bowel disease|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/10/20	2014/12/23	rogid:ieBLcDINn9hZFZZEIQ3Ktdf2NF89606	rogid:jioNJRDtKJU8iwI+dNq4JSEHRoI9606	intact-crc:FC8B5A075C4B8020|rigid:E29oT5iStAyNI0uMGHT2XKHWV4w	false	glutathione s tranferase tag:n-n	myc tag:n-n	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)