#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P03132	uniprotkb:Q9NS56	intact:EBI-7387242|intact:MINT-6732280|uniprotkb:O56650	intact:EBI-1996473|uniprotkb:O43273|uniprotkb:Q6P987|uniprotkb:Q9NS55|uniprotkb:Q9UNR9|ensembl:ENSP00000353735	psi-mi:rep68_aav2s(display_long)|uniprotkb:Rep68(gene name)|psi-mi:Rep68(display_short)	psi-mi:toprs_human(display_long)|uniprotkb:TOPORS(gene name)|psi-mi:TOPORS(display_short)|uniprotkb:LUN(gene name synonym)|uniprotkb:TP53BPL(gene name synonym)|uniprotkb:SUMO1-protein E3 ligase Topors(gene name synonym)|uniprotkb:Topoisomerase I-binding RING finger protein(gene name synonym)|uniprotkb:Topoisomerase I-binding arginine/serine-rich protein(gene name synonym)|uniprotkb:Tumor suppressor p53-binding protein 3(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase Topors(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Weger et al. (2002)	pubmed:11842245|imex:IM-22531	taxid:648242(aav-2)|taxid:648242("Adeno-associated virus 2 (isolate Srivastava/1982)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-9510764|imex:IM-22531-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	mint:P03132|interpro:IPR014835(Rep protein catalytic  like)|interpro:IPR014015(Helicase, superfamily 3, DNA virus)|interpro:IPR027417|interpro:IPR001257(Non-structural protein NS1, parvovirus)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0006260"(DNA replication)|go:"GO:0039592"(suppression by virus of G2/M transition of host mitotic cell cycle)|go:"GO:0039645"(modulation by virus of host G1/S transition checkpoint)|go:"GO:0039665"(permeabilization of host organelle membrane involved in viral entry into host cell)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0099008"(viral entry via permeabilization of inner membrane)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|rcsb pdb:1S9H|rcsb pdb:1U0J|rcsb pdb:4ZO0|rcsb pdb:4ZQ9|rcsb pdb:5DCX|rcsb pdb:6XB8|rcsb pdb:7JSE|rcsb pdb:7JSF|rcsb pdb:7JSG|rcsb pdb:7JSH|rcsb pdb:7JSI|refseq:YP_680422.1	refseq:NP_001182551.1|refseq:NP_005793.2|ensembl:ENSG00000197579(gene)|ensembl:ENST00000360538(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000922"(spindle pole)|go:"GO:0000930"(gamma-tubulin complex)|go:"GO:0003677"(DNA binding)|go:"GO:0003823"(antigen binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005814"(centriole)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006513"(protein monoubiquitination)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0010842"(retina layer formation)|go:"GO:0016605"(PML body)|go:"GO:0016607"(nuclear speck)|go:"GO:0016925"(protein sumoylation)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0030496"(midbody)|go:"GO:0032391"(photoreceptor connecting cilium)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0035845"(photoreceptor cell outer segment organization)|go:"GO:0036064"(ciliary basal body)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042771"(intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0044547"(DNA topoisomerase binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046548"(retinal rod cell development)|go:"GO:0046549"(retinal cone cell development)|go:"GO:0046872"(metal ion binding)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0051457"(maintenance of protein location in nucleus)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070936"(protein K48-linked ubiquitination)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|mint:Q9NS56|reactome:R-HSA-3899300|reactome:R-HSA-4085377|reactome:R-HSA-4755510	-	function:Essential for DNA replication|comment:mint	-	figure legend:no figure|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/04/25	2014/10/16	rogid:12Ix12baqUBye/kP6FE/rjM69zY648242	rogid:8KlxsG2SOxo/Li/zMRdUsXbhNlg9606	intact-crc:7330C9942DFBD64D|rigid:SeQuGh64DeFzCc+F0A7qdH8bH60	false	sufficient binding region:172-530	sufficient binding region:854-1045	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9NS56	uniprotkb:P02340	intact:EBI-1996473|uniprotkb:O43273|uniprotkb:Q6P987|uniprotkb:Q9NS55|uniprotkb:Q9UNR9|ensembl:ENSP00000353735	intact:EBI-474016|uniprotkb:Q9QUP3|ensembl:ENSMUSP00000104298	psi-mi:toprs_human(display_long)|uniprotkb:TOPORS(gene name)|psi-mi:TOPORS(display_short)|uniprotkb:LUN(gene name synonym)|uniprotkb:TP53BPL(gene name synonym)|uniprotkb:SUMO1-protein E3 ligase Topors(gene name synonym)|uniprotkb:Topoisomerase I-binding RING finger protein(gene name synonym)|uniprotkb:Topoisomerase I-binding arginine/serine-rich protein(gene name synonym)|uniprotkb:Tumor suppressor p53-binding protein 3(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase Topors(gene name synonym)	psi-mi:p53_mouse(display_long)|uniprotkb:Tp53(gene name)|psi-mi:Tp53(display_short)|uniprotkb:P53(gene name synonym)|uniprotkb:Trp53(gene name synonym)|uniprotkb:Tumor suppressor p53(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Weger et al. (2002)	pubmed:11842245|imex:IM-22531	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-9510815|imex:IM-22531-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001182551.1|refseq:NP_005793.2|ensembl:ENSG00000197579(gene)|ensembl:ENST00000360538(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000922"(spindle pole)|go:"GO:0000930"(gamma-tubulin complex)|go:"GO:0003677"(DNA binding)|go:"GO:0003823"(antigen binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005814"(centriole)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006513"(protein monoubiquitination)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0010842"(retina layer formation)|go:"GO:0016605"(PML body)|go:"GO:0016607"(nuclear speck)|go:"GO:0016925"(protein sumoylation)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0030496"(midbody)|go:"GO:0032391"(photoreceptor connecting cilium)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0035845"(photoreceptor cell outer segment organization)|go:"GO:0036064"(ciliary basal body)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042771"(intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0044547"(DNA topoisomerase binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046548"(retinal rod cell development)|go:"GO:0046549"(retinal cone cell development)|go:"GO:0046872"(metal ion binding)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0051457"(maintenance of protein location in nucleus)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070936"(protein K48-linked ubiquitination)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|mint:Q9NS56|reactome:R-HSA-3899300|reactome:R-HSA-4085377|reactome:R-HSA-4755510	ensembl:ENSMUSG00000059552(gene)|ensembl:ENSMUST00000108658(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001046"(core promoter sequence-specific DNA binding)|go:"GO:0001094"(TFIID-class transcription factor complex binding)|go:"GO:0001216"(DNA-binding transcription activator activity)|go:"GO:0001221"(transcription coregulator binding)|go:"GO:0072331"(signal transduction by p53 class mediator)|go:"GO:0072332"(intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:0072717"(cellular response to actinomycin D)|go:"GO:0090200"(positive regulation of release of cytochrome c from mitochondria)|go:"GO:0090343"(positive regulation of cell aging)|go:"GO:0090399"(replicative senescence)|go:"GO:0090403"(oxidative stress-induced premature senescence)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:0097252"(oligodendrocyte apoptotic process)|go:"GO:0097371"(MDM2/MDM4 family protein binding)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:1900119"(positive regulation of execution phase of apoptosis)|go:"GO:1901525"(negative regulation of mitophagy)|go:"GO:1902108"(regulation of mitochondrial membrane permeability involved in apoptotic process)|go:"GO:1902253"(regulation of intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1903205"(regulation of hydrogen peroxide-induced cell death)|go:"GO:1903799"(negative regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1903800"(positive regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1904024"(negative regulation of glucose catabolic process to lactate via pyruvate)|go:"GO:1905856"(negative regulation of pentose-phosphate shunt)|go:"GO:1990144"(intrinsic apoptotic signaling pathway in response to hypoxia)|go:"GO:1990248"(regulation of transcription from RNA polymerase II promoter in response to DNA damage)|go:"GO:1990440"(positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress)|go:"GO:1990841"(promoter-specific chromatin binding)|go:"GO:2000269"(regulation of fibroblast apoptotic process)|go:"GO:2000279"(negative regulation of DNA biosynthetic process)|go:"GO:2000378"(negative regulation of reactive oxygen species metabolic process)|go:"GO:0071494"(cellular response to UV-C)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|go:"GO:2000772"(regulation of cellular senescence)|go:"GO:2001244"(positive regulation of intrinsic apoptotic signaling pathway)|interpro:IPR002117(p53 tumor antigen)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR010991(p53, tetramerisation)|interpro:IPR011615(p53, DNA-binding)|interpro:IPR012346(p53 and RUNT-type transcription factor, DNA-binding)|interpro:IPR013872("p53 transactivation domain (TAD)")|interpro:IPR036674|mint:P02340|rcsb pdb:1HU8|rcsb pdb:2GEQ|rcsb pdb:2IOI|rcsb pdb:2IOM|rcsb pdb:2IOO|rcsb pdb:2P52|rcsb pdb:3EXJ|rcsb pdb:3EXL|reactome:R-MMU-2559580|reactome:R-MMU-2559584|reactome:R-MMU-2559585|reactome:R-MMU-2559586|reactome:R-MMU-349425|reactome:R-MMU-5689880|reactome:R-MMU-5689896|reactome:R-MMU-5693565|reactome:R-MMU-6804754|reactome:R-MMU-6804756|reactome:R-MMU-6804757|reactome:R-MMU-6804758|reactome:R-MMU-6804759|reactome:R-MMU-6804760|reactome:R-MMU-6811555|reactome:R-MMU-69473|reactome:R-MMU-69481|reactome:R-MMU-69541|reactome:R-MMU-69895|reactome:R-MMU-8852276|reactome:R-MMU-8941855|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001756"(somitogenesis)|go:"GO:0001836"(release of cytochrome c from mitochondria)|go:"GO:0002020"(protease binding)|go:"GO:0002039"(p53 binding)|go:"GO:0002244"(hematopoietic progenitor cell differentiation)|go:"GO:0002309"(T cell proliferation involved in immune response)|go:"GO:0002326"(B cell lineage commitment)|go:"GO:0002360"(T cell lineage commitment)|go:"GO:0002687"(positive regulation of leukocyte migration)|go:"GO:0002931"(response to ischemia)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005507"(copper ion binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005657"(replication fork)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006289"(nucleotide-excision repair)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006914"(autophagy)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0006977"(DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest)|go:"GO:0006978"(DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0006983"(ER overload response)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007346"(regulation of mitotic cell cycle)|go:"GO:0007369"(gastrulation)|go:"GO:0007406"(negative regulation of neuroblast proliferation)|go:"GO:0007417"(central nervous system development)|go:"GO:0007507"(heart development)|go:"GO:0007569"(cell aging)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008104"(protein localization)|go:"GO:0008156"(negative regulation of DNA replication)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0009299"(mRNA transcription)|go:"GO:0009303"(rRNA transcription)|go:"GO:0009411"(response to UV)|go:"GO:0009651"(response to salt stress)|go:"GO:0009792"(embryo development ending in birth or egg hatching)|go:"GO:0010038"(response to metal ion)|go:"GO:0010165"(response to X-ray)|go:"GO:0010224"(response to UV-B)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010666"(positive regulation of cardiac muscle cell apoptotic process)|go:"GO:0016032"(viral process)|go:"GO:0016363"(nuclear matrix)|go:"GO:0016605"(PML body)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0021549"(cerebellum development)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030330"(DNA damage response, signal transduction by p53 class mediator)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0031000"(response to caffeine)|go:"GO:0031065"(positive regulation of histone deacetylation)|go:"GO:0031497"(chromatin assembly)|go:"GO:0031571"(mitotic G1 DNA damage checkpoint signaling)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0033552"(response to vitamin B3)|go:"GO:0034103"(regulation of tissue remodeling)|go:"GO:0034605"(cellular response to heat)|go:"GO:0034613"(cellular protein localization)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035033"(histone deacetylase regulator activity)|go:"GO:0035035"(histone acetyltransferase binding)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0035690"|go:"GO:0035794"(positive regulation of mitochondrial membrane permeability)|go:"GO:0035861"(site of double-strand break)|go:"GO:0036003"(positive regulation of transcription from RNA polymerase II promoter in response to stress)|go:"GO:0036310"(ATP-dependent DNA/DNA annealing activity)|go:"GO:0042060"(wound healing)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0042493"|go:"GO:0042771"(intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043153"(entrainment of circadian clock by photoperiod)|go:"GO:0043200"(response to amino acid)|go:"GO:0043504"(mitochondrial DNA repair)|go:"GO:0043516"(regulation of DNA damage response, signal transduction by p53 class mediator)|go:"GO:0043523"(regulation of neuron apoptotic process)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0043621"(protein self-association)|go:"GO:0045471"(response to ethanol)|go:"GO:0045787"(positive regulation of cell cycle)|go:"GO:0045861"(negative regulation of proteolysis)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045899"(positive regulation of RNA polymerase II transcription preinitiation complex assembly)|go:"GO:0045930"(negative regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048147"(negative regulation of fibroblast proliferation)|go:"GO:0048512"(circadian behavior)|go:"GO:0048539"(bone marrow development)|go:"GO:0048568"(embryonic organ development)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0051262"(protein tetramerization)|go:"GO:0051276"(chromosome organization)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0051453"(regulation of intracellular pH)|go:"GO:0051721"(protein phosphatase 2A binding)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051974"(negative regulation of telomerase activity)|go:"GO:0055093"(response to hyperoxia)|go:"GO:0060218"(hematopoietic stem cell differentiation)|go:"GO:0060333"(interferon-gamma-mediated signaling pathway)|go:"GO:0060411"(cardiac septum morphogenesis)|go:"GO:0061419"(positive regulation of transcription from RNA polymerase II promoter in response to hypoxia)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0062100"(positive regulation of programmed necrotic cell death)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070243"(regulation of thymocyte apoptotic process)|go:"GO:0070245"(positive regulation of thymocyte apoptotic process)|go:"GO:0070266"(necroptotic process)|go:"GO:0071479"(cellular response to ionizing radiation)|go:"GO:0071480"(cellular response to gamma radiation)|go:"GO:0034644"(cellular response to UV)|refseq:NP_001120705.1|refseq:NP_035770.2|refseq:XP_006533220.1|dip:DIP-369N	-	-	-	figure legend:2B and C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/04/25	2018/10/11	rogid:8KlxsG2SOxo/Li/zMRdUsXbhNlg9606	rogid:ZU1071LBVm95uqzi6RBNluw8wFo10090	intact-crc:7CB4097F12708A0A|rigid:fM7qzwNQEq6bdYUmuMdKs/lD1Zk	false	sufficient binding region:415-644|necessary binding region:911-917	sufficient binding region:75..75-390	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P03132	uniprotkb:Q9NS56	intact:EBI-7387242|intact:MINT-6732280|uniprotkb:O56650	intact:EBI-1996473|uniprotkb:O43273|uniprotkb:Q6P987|uniprotkb:Q9NS55|uniprotkb:Q9UNR9|ensembl:ENSP00000353735	psi-mi:rep68_aav2s(display_long)|uniprotkb:Rep68(gene name)|psi-mi:Rep68(display_short)	psi-mi:toprs_human(display_long)|uniprotkb:TOPORS(gene name)|psi-mi:TOPORS(display_short)|uniprotkb:LUN(gene name synonym)|uniprotkb:TP53BPL(gene name synonym)|uniprotkb:SUMO1-protein E3 ligase Topors(gene name synonym)|uniprotkb:Topoisomerase I-binding RING finger protein(gene name synonym)|uniprotkb:Topoisomerase I-binding arginine/serine-rich protein(gene name synonym)|uniprotkb:Tumor suppressor p53-binding protein 3(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase Topors(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Weger et al. (2002)	pubmed:11842245|imex:IM-22531	taxid:648242(aav-2)|taxid:648242("Adeno-associated virus 2 (isolate Srivastava/1982)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-9510789|imex:IM-22531-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	mint:P03132|interpro:IPR014835(Rep protein catalytic  like)|interpro:IPR014015(Helicase, superfamily 3, DNA virus)|interpro:IPR027417|interpro:IPR001257(Non-structural protein NS1, parvovirus)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0006260"(DNA replication)|go:"GO:0039592"(suppression by virus of G2/M transition of host mitotic cell cycle)|go:"GO:0039645"(modulation by virus of host G1/S transition checkpoint)|go:"GO:0039665"(permeabilization of host organelle membrane involved in viral entry into host cell)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0099008"(viral entry via permeabilization of inner membrane)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|rcsb pdb:1S9H|rcsb pdb:1U0J|rcsb pdb:4ZO0|rcsb pdb:4ZQ9|rcsb pdb:5DCX|rcsb pdb:6XB8|rcsb pdb:7JSE|rcsb pdb:7JSF|rcsb pdb:7JSG|rcsb pdb:7JSH|rcsb pdb:7JSI|refseq:YP_680422.1	refseq:NP_001182551.1|refseq:NP_005793.2|ensembl:ENSG00000197579(gene)|ensembl:ENST00000360538(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000922"(spindle pole)|go:"GO:0000930"(gamma-tubulin complex)|go:"GO:0003677"(DNA binding)|go:"GO:0003823"(antigen binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005814"(centriole)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006513"(protein monoubiquitination)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0010842"(retina layer formation)|go:"GO:0016605"(PML body)|go:"GO:0016607"(nuclear speck)|go:"GO:0016925"(protein sumoylation)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0030496"(midbody)|go:"GO:0032391"(photoreceptor connecting cilium)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0035845"(photoreceptor cell outer segment organization)|go:"GO:0036064"(ciliary basal body)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042771"(intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0044547"(DNA topoisomerase binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046548"(retinal rod cell development)|go:"GO:0046549"(retinal cone cell development)|go:"GO:0046872"(metal ion binding)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0051457"(maintenance of protein location in nucleus)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070936"(protein K48-linked ubiquitination)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|mint:Q9NS56|reactome:R-HSA-3899300|reactome:R-HSA-4085377|reactome:R-HSA-4755510	-	function:Essential for DNA replication|comment:mint	-	figure legend:2A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/04/25	2014/10/16	rogid:12Ix12baqUBye/kP6FE/rjM69zY648242	rogid:8KlxsG2SOxo/Li/zMRdUsXbhNlg9606	intact-crc:B0346C898967D294|rigid:SeQuGh64DeFzCc+F0A7qdH8bH60	false	necessary binding region:172-481|mutation increasing interaction:340-340	sufficient binding region:854-1045	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P03132	uniprotkb:Q9NS56	intact:EBI-7387242|intact:MINT-6732280|uniprotkb:O56650	intact:EBI-1996473|uniprotkb:O43273|uniprotkb:Q6P987|uniprotkb:Q9NS55|uniprotkb:Q9UNR9|ensembl:ENSP00000353735	psi-mi:rep68_aav2s(display_long)|uniprotkb:Rep68(gene name)|psi-mi:Rep68(display_short)	psi-mi:toprs_human(display_long)|uniprotkb:TOPORS(gene name)|psi-mi:TOPORS(display_short)|uniprotkb:LUN(gene name synonym)|uniprotkb:TP53BPL(gene name synonym)|uniprotkb:SUMO1-protein E3 ligase Topors(gene name synonym)|uniprotkb:Topoisomerase I-binding RING finger protein(gene name synonym)|uniprotkb:Topoisomerase I-binding arginine/serine-rich protein(gene name synonym)|uniprotkb:Tumor suppressor p53-binding protein 3(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase Topors(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Weger et al. (2002)	pubmed:11842245|imex:IM-22531	taxid:648242(aav-2)|taxid:648242("Adeno-associated virus 2 (isolate Srivastava/1982)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-9510801|imex:IM-22531-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	mint:P03132|interpro:IPR014835(Rep protein catalytic  like)|interpro:IPR014015(Helicase, superfamily 3, DNA virus)|interpro:IPR027417|interpro:IPR001257(Non-structural protein NS1, parvovirus)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0006260"(DNA replication)|go:"GO:0039592"(suppression by virus of G2/M transition of host mitotic cell cycle)|go:"GO:0039645"(modulation by virus of host G1/S transition checkpoint)|go:"GO:0039665"(permeabilization of host organelle membrane involved in viral entry into host cell)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0099008"(viral entry via permeabilization of inner membrane)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|rcsb pdb:1S9H|rcsb pdb:1U0J|rcsb pdb:4ZO0|rcsb pdb:4ZQ9|rcsb pdb:5DCX|rcsb pdb:6XB8|rcsb pdb:7JSE|rcsb pdb:7JSF|rcsb pdb:7JSG|rcsb pdb:7JSH|rcsb pdb:7JSI|refseq:YP_680422.1	refseq:NP_001182551.1|refseq:NP_005793.2|ensembl:ENSG00000197579(gene)|ensembl:ENST00000360538(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000922"(spindle pole)|go:"GO:0000930"(gamma-tubulin complex)|go:"GO:0003677"(DNA binding)|go:"GO:0003823"(antigen binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005814"(centriole)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006513"(protein monoubiquitination)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0010842"(retina layer formation)|go:"GO:0016605"(PML body)|go:"GO:0016607"(nuclear speck)|go:"GO:0016925"(protein sumoylation)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0030496"(midbody)|go:"GO:0032391"(photoreceptor connecting cilium)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0035845"(photoreceptor cell outer segment organization)|go:"GO:0036064"(ciliary basal body)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042771"(intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0044547"(DNA topoisomerase binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046548"(retinal rod cell development)|go:"GO:0046549"(retinal cone cell development)|go:"GO:0046872"(metal ion binding)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0051457"(maintenance of protein location in nucleus)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070936"(protein K48-linked ubiquitination)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|mint:Q9NS56|reactome:R-HSA-3899300|reactome:R-HSA-4085377|reactome:R-HSA-4755510	-	function:Essential for DNA replication|comment:mint	-	figure legend:2B and C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2014/04/25	2014/10/16	rogid:12Ix12baqUBye/kP6FE/rjM69zY648242	rogid:8KlxsG2SOxo/Li/zMRdUsXbhNlg9606	intact-crc:D6627ADE3B6B3F1C|rigid:SeQuGh64DeFzCc+F0A7qdH8bH60	false	sufficient binding region:1-481	necessary binding region:911-917|sufficient binding region:871-917	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q89268	uniprotkb:Q9NS56	intact:EBI-9485551|uniprotkb:O56651	intact:EBI-1996473|uniprotkb:O43273|uniprotkb:Q6P987|uniprotkb:Q9NS55|uniprotkb:Q9UNR9|ensembl:ENSP00000353735	psi-mi:rep78_aav2s(display_long)|uniprotkb:Rep78(gene name)|psi-mi:Rep78(display_short)	psi-mi:toprs_human(display_long)|uniprotkb:TOPORS(gene name)|psi-mi:TOPORS(display_short)|uniprotkb:LUN(gene name synonym)|uniprotkb:TP53BPL(gene name synonym)|uniprotkb:SUMO1-protein E3 ligase Topors(gene name synonym)|uniprotkb:Topoisomerase I-binding RING finger protein(gene name synonym)|uniprotkb:Topoisomerase I-binding arginine/serine-rich protein(gene name synonym)|uniprotkb:Tumor suppressor p53-binding protein 3(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase Topors(gene name synonym)	psi-mi:"MI:0096"(pull down)	Weger et al. (2002)	pubmed:11842245|imex:IM-22531	taxid:648242(aav-2)|taxid:648242("Adeno-associated virus 2 (isolate Srivastava/1982)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-9510865|imex:IM-22531-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR014015(Helicase, superfamily 3, DNA virus)|interpro:IPR027417|interpro:IPR001257(Non-structural protein NS1, parvovirus)|interpro:IPR014835(Rep protein catalytic  like)|rcsb pdb:5BYG|refseq:YP_680423.1|go:"GO:0005524"(ATP binding)|go:"GO:0006260"(DNA replication)|go:"GO:0039592"(suppression by virus of G2/M transition of host mitotic cell cycle)|go:"GO:0039645"(modulation by virus of host G1/S transition checkpoint)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)	refseq:NP_001182551.1|refseq:NP_005793.2|ensembl:ENSG00000197579(gene)|ensembl:ENST00000360538(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000922"(spindle pole)|go:"GO:0000930"(gamma-tubulin complex)|go:"GO:0003677"(DNA binding)|go:"GO:0003823"(antigen binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005814"(centriole)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006513"(protein monoubiquitination)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0010842"(retina layer formation)|go:"GO:0016605"(PML body)|go:"GO:0016607"(nuclear speck)|go:"GO:0016925"(protein sumoylation)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0030496"(midbody)|go:"GO:0032391"(photoreceptor connecting cilium)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0035845"(photoreceptor cell outer segment organization)|go:"GO:0036064"(ciliary basal body)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042771"(intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0044547"(DNA topoisomerase binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046548"(retinal rod cell development)|go:"GO:0046549"(retinal cone cell development)|go:"GO:0046872"(metal ion binding)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0051457"(maintenance of protein location in nucleus)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070936"(protein K48-linked ubiquitination)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|mint:Q9NS56|reactome:R-HSA-3899300|reactome:R-HSA-4085377|reactome:R-HSA-4755510	-	-	-	figure legend:1B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2014/04/25	2014/10/16	rogid:CRl4VPCCbv4a09MrPhwOddP9gG8648242	rogid:8KlxsG2SOxo/Li/zMRdUsXbhNlg9606	intact-crc:780387AA56446B63|rigid:rrbD5je4UHRlcq0HYl3mxqJQHSI	false	35s radiolabel:?-?	glutathione s tranferase tag:?-?|sufficient binding region:854-1045	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)