#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q9Y248	uniprotkb:Q9BTE3	intact:EBI-747491|uniprotkb:Q6IAG9|uniprotkb:D3DUM5|ensembl:ENSP00000253462	intact:EBI-749378|uniprotkb:Q6IA56|uniprotkb:Q9BVT9|uniprotkb:Q9H916|uniprotkb:B3KSP7|ensembl:ENSP00000353098	psi-mi:psf2_human(display_long)|uniprotkb:GINS complex subunit 2(gene name synonym)|uniprotkb:GINS2(gene name)|psi-mi:GINS2(display_short)|uniprotkb:CGI-122(orf name)|uniprotkb:DC5(orf name)|uniprotkb:HSPC037(orf name)|uniprotkb:PSF2(gene name synonym)	psi-mi:mcmbp_human(display_long)|uniprotkb:MCMBP(gene name)|psi-mi:MCMBP(display_short)|uniprotkb:C10orf119(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Kusunoki et al. (2013)	pubmed:24299456|imex:IM-22017	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-9002813|imex:IM-22017-14	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_057179.1|dip:DIP-29332N|ensembl:ENSG00000131153(gene)|ensembl:ENST00000253462(transcript)|go:"GO:0000727"(double-strand break repair via break-induced replication)|go:"GO:0000811"(GINS complex)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006260"(DNA replication)|go:"GO:0071162"(CMG complex)|interpro:IPR007257(GINS complex, Psf2 component)|interpro:IPR021151|interpro:IPR036224|mint:Q9Y248|rcsb pdb:2E9X|rcsb pdb:2EHO|rcsb pdb:2Q9Q|rcsb pdb:6XTX|rcsb pdb:6XTY|reactome:R-HSA-176974	refseq:NP_079110.1|refseq:NP_001243307.1|refseq:NP_001243308.1|ensembl:ENSG00000197771(gene)|ensembl:ENST00000360003(transcript)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006261"(DNA-dependent DNA replication)|go:"GO:0007062"(sister chromatid cohesion)|go:"GO:0030054"(cell junction)|go:"GO:0051301"(cell division)|interpro:IPR019140|rcsb pdb:4KG9	-	-	-	figure legend:sf1b|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:7111(trini-high_5)|taxid:7111(Trichoplusia ni cell line from eggs)	-	2013/11/27	2014/10/16	rogid:OKFZLWhkmZNQxqS2tKptq61jsxs9606	rogid:8mXHWwvrQneZZArPvAEj1JZwOrg9606	intact-crc:52B2037C942F37E2|rigid:tU1RZZqtuQbzh1ye8eq20/Itdnw	false	myc tag:?-?	flag tag:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9BTE3	uniprotkb:P33992	intact:EBI-749378|uniprotkb:Q6IA56|uniprotkb:Q9BVT9|uniprotkb:Q9H916|uniprotkb:B3KSP7|ensembl:ENSP00000353098	intact:EBI-359410|ensembl:ENSP00000216122|uniprotkb:O60785|uniprotkb:Q14578|uniprotkb:Q9BTJ4|uniprotkb:Q9BWL8	psi-mi:mcmbp_human(display_long)|uniprotkb:MCMBP(gene name)|psi-mi:MCMBP(display_short)|uniprotkb:C10orf119(gene name synonym)	psi-mi:mcm5_human(display_long)|uniprotkb:MCM5(gene name)|psi-mi:MCM5(display_short)|uniprotkb:CDC46(gene name synonym)|uniprotkb:CDC46 homolog(gene name synonym)|uniprotkb:P1-CDC46(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Kusunoki et al. (2013)	pubmed:24299456|imex:IM-22017	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-9002750|imex:IM-22017-9	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_079110.1|refseq:NP_001243307.1|refseq:NP_001243308.1|ensembl:ENSG00000197771(gene)|ensembl:ENST00000360003(transcript)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006261"(DNA-dependent DNA replication)|go:"GO:0007062"(sister chromatid cohesion)|go:"GO:0030054"(cell junction)|go:"GO:0051301"(cell division)|interpro:IPR019140|rcsb pdb:4KG9	ensembl:ENSG00000100297(gene)|ensembl:ENST00000216122(transcript)|go:"GO:0000727"(double-strand break repair via break-induced replication)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006260"(DNA replication)|go:"GO:0006267"(pre-replicative complex assembly involved in nuclear cell cycle DNA replication)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0016020"(membrane)|go:"GO:0042555"(MCM complex)|go:"GO:0071162"(CMG complex)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR001208(MCM)|interpro:IPR008048(MCM protein 5)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|interpro:IPR018525|interpro:IPR027417|interpro:IPR027925|interpro:IPR031327|interpro:IPR033762|interpro:IPR041562|mint:P33992|rcsb pdb:6XTX|rcsb pdb:6XTY|reactome:R-HSA-176187|reactome:R-HSA-176974|reactome:R-HSA-68867|reactome:R-HSA-68949|refseq:NP_006730.2|reactome:R-HSA-69052|reactome:R-HSA-68962|dip:DIP-27578N	-	-	-	figure legend:sf1a|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:7111(trini-high_5)|taxid:7111(Trichoplusia ni cell line from eggs)	-	2013/11/27	2014/10/16	rogid:8mXHWwvrQneZZArPvAEj1JZwOrg9606	rogid:WjJ4lSpADQFtwT0WnumbRHl/lPw9606	intact-crc:74A48275F43A3CEB|rigid:yEvcHetw1d6HZEb70/+I2sXn+e0	false	flag tag:?-?	his tag:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q14566	uniprotkb:Q9BTE3	intact:EBI-374900|uniprotkb:Q13504|uniprotkb:Q99859|uniprotkb:B2R6H2|ensembl:ENSP00000264156	intact:EBI-749378|uniprotkb:Q6IA56|uniprotkb:Q9BVT9|uniprotkb:Q9H916|uniprotkb:B3KSP7|ensembl:ENSP00000353098	psi-mi:mcm6_human(display_long)|uniprotkb:MCM6(gene name)|psi-mi:MCM6(display_short)|uniprotkb:p105MCM(gene name synonym)	psi-mi:mcmbp_human(display_long)|uniprotkb:MCMBP(gene name)|psi-mi:MCMBP(display_short)|uniprotkb:C10orf119(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Kusunoki et al. (2013)	pubmed:24299456|imex:IM-22017	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-9002742|imex:IM-22017-8	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENST00000264156(transcript)|go:"GO:0000727"(double-strand break repair via break-induced replication)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006260"(DNA replication)|go:"GO:0006267"(pre-replicative complex assembly involved in nuclear cell cycle DNA replication)|go:"GO:0006268"(DNA unwinding involved in DNA replication)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0042555"(MCM complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0071162"(CMG complex)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1902969"(mitotic DNA replication)|ensembl:ENSG00000076003(gene)|reactome:R-HSA-68962|reactome:R-HSA-69052|interpro:IPR008049(MCM protein 6)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|interpro:IPR018525|interpro:IPR027417|interpro:IPR027925|interpro:IPR031327|interpro:IPR033762|interpro:IPR041024|interpro:IPR041562|interpro:IPR001208(MCM)|mint:Q14566|rcsb pdb:2KLQ|rcsb pdb:2LE8|rcsb pdb:6XTX|rcsb pdb:6XTY|reactome:R-HSA-176187|reactome:R-HSA-176974|reactome:R-HSA-68867|reactome:R-HSA-68949|refseq:NP_005906.2|dip:DIP-31727N	refseq:NP_079110.1|refseq:NP_001243307.1|refseq:NP_001243308.1|ensembl:ENSG00000197771(gene)|ensembl:ENST00000360003(transcript)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006261"(DNA-dependent DNA replication)|go:"GO:0007062"(sister chromatid cohesion)|go:"GO:0030054"(cell junction)|go:"GO:0051301"(cell division)|interpro:IPR019140|rcsb pdb:4KG9	-	-	-	figure legend:sf1a|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:7111(trini-high_5)|taxid:7111(Trichoplusia ni cell line from eggs)	-	2013/11/27	2014/10/16	rogid:gVpEwgfSwwxvP2T2CvCzIukthY49606	rogid:8mXHWwvrQneZZArPvAEj1JZwOrg9606	intact-crc:DF042336A6026E0D|rigid:ErrExehY0q6whP1sy1vQYpfOng4	false	-	flag tag:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9BTE3	uniprotkb:P49736	intact:EBI-749378|uniprotkb:Q6IA56|uniprotkb:Q9BVT9|uniprotkb:Q9H916|uniprotkb:B3KSP7|ensembl:ENSP00000353098	intact:EBI-374819|uniprotkb:Q14577|uniprotkb:Q15023|uniprotkb:Q8N2V1|uniprotkb:Q969W7|uniprotkb:Q96AE1|uniprotkb:Q9BRM7|ensembl:ENSP00000265056	psi-mi:mcmbp_human(display_long)|uniprotkb:MCMBP(gene name)|psi-mi:MCMBP(display_short)|uniprotkb:C10orf119(gene name synonym)	psi-mi:mcm2_human(display_long)|uniprotkb:MCM2(gene name)|psi-mi:MCM2(display_short)|uniprotkb:BM28(gene name synonym)|uniprotkb:CDCL1(gene name synonym)|uniprotkb:KIAA0030(gene name synonym)|uniprotkb:Minichromosome maintenance protein 2 homolog(gene name synonym)|uniprotkb:Nuclear protein BM28(gene name synonym)|uniprotkb:CCNL1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Kusunoki et al. (2013)	pubmed:24299456|imex:IM-22017	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-9002722|imex:IM-22017-6	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_079110.1|refseq:NP_001243307.1|refseq:NP_001243308.1|ensembl:ENSG00000197771(gene)|ensembl:ENST00000360003(transcript)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006261"(DNA-dependent DNA replication)|go:"GO:0007062"(sister chromatid cohesion)|go:"GO:0030054"(cell junction)|go:"GO:0051301"(cell division)|interpro:IPR019140|rcsb pdb:4KG9	ensembl:ENSG00000073111(gene)|ensembl:ENST00000265056(transcript)|go:"GO:0000727"(double-strand break repair via break-induced replication)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000785"(chromatin)|go:"GO:0003677"(DNA binding)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005664"(nuclear origin of replication recognition complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0006260"(DNA replication)|go:"GO:0006267"(pre-replicative complex assembly involved in nuclear cell cycle DNA replication)|go:"GO:0006268"(DNA unwinding involved in DNA replication)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0006915"(apoptotic process)|go:"GO:0019899"(enzyme binding)|go:"GO:0042393"(histone binding)|go:"GO:0042555"(MCM complex)|go:"GO:0046872"(metal ion binding)|go:"GO:0071162"(CMG complex)|go:"GO:0071353"(cellular response to interleukin-4)|go:"GO:0090102"(cochlea development)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1902975"(mitotic DNA replication initiation)|go:"GO:1905775"(negative regulation of DNA helicase activity)|interpro:IPR001208(MCM)|interpro:IPR008045(MCM protein 2)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|interpro:IPR018525|interpro:IPR027417|interpro:IPR027925|interpro:IPR031327|interpro:IPR033762|interpro:IPR041562|mint:P49736|rcsb pdb:4UUZ|rcsb pdb:5BNV|rcsb pdb:5BNX|rcsb pdb:5BO0|rcsb pdb:5C3I|rcsb pdb:5JA4|rcsb pdb:6XTX|rcsb pdb:6XTY|rcsb pdb:6YA7|rcsb pdb:7CIZ|rcsb pdb:7CJ0|reactome:R-HSA-176187|reactome:R-HSA-176974|reactome:R-HSA-68867|reactome:R-HSA-68949|reactome:R-HSA-68962|reactome:R-HSA-69052|refseq:NP_004517.2|dip:DIP-31732N	-	-	-	figure legend:sf1a|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:7111(trini-high_5)|taxid:7111(Trichoplusia ni cell line from eggs)	-	2013/11/27	2014/10/16	rogid:8mXHWwvrQneZZArPvAEj1JZwOrg9606	rogid:Jt9ODNyJBwtwQ0pb/+X46vtHfE09606	intact-crc:7301AE643A276227|rigid:SkHLHmnadOA/hDjSQN0kc0mLDv4	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9BTE3	uniprotkb:P33993	intact:EBI-749378|uniprotkb:Q6IA56|uniprotkb:Q9BVT9|uniprotkb:Q9H916|uniprotkb:B3KSP7|ensembl:ENSP00000353098	intact:EBI-355924|uniprotkb:Q15076|uniprotkb:Q96D34|uniprotkb:Q96GL1|uniprotkb:A4D2A1|uniprotkb:A4D2A2|uniprotkb:E9PGN9|ensembl:ENSP00000307288	psi-mi:mcmbp_human(display_long)|uniprotkb:MCMBP(gene name)|psi-mi:MCMBP(display_short)|uniprotkb:C10orf119(gene name synonym)	psi-mi:mcm7_human(display_long)|uniprotkb:MCM7(gene name)|psi-mi:MCM7(display_short)|uniprotkb:CDC47(gene name synonym)|uniprotkb:MCM2(gene name synonym)|uniprotkb:CDC47 homolog(gene name synonym)|uniprotkb:P1.1-MCM3(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Kusunoki et al. (2013)	pubmed:24299456|imex:IM-22017	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8875806|imex:IM-22017-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_079110.1|refseq:NP_001243307.1|refseq:NP_001243308.1|ensembl:ENSG00000197771(gene)|ensembl:ENST00000360003(transcript)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006261"(DNA-dependent DNA replication)|go:"GO:0007062"(sister chromatid cohesion)|go:"GO:0030054"(cell junction)|go:"GO:0051301"(cell division)|interpro:IPR019140|rcsb pdb:4KG9	refseq:NP_001265524.1|refseq:NP_005907.3|refseq:NP_877577.1|ensembl:ENSG00000166508(gene)|ensembl:ENST00000303887(transcript)|go:"GO:0000727"(double-strand break repair via break-induced replication)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000785"(chromatin)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0016020"(membrane)|go:"GO:0042325"(regulation of phosphorylation)|go:"GO:0042493"|go:"GO:0042555"(MCM complex)|go:"GO:0071162"(CMG complex)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0071466"(cellular response to xenobiotic stimulus)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR001208(MCM)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006260"(DNA replication)|go:"GO:0006267"(pre-replicative complex assembly involved in nuclear cell cycle DNA replication)|go:"GO:0006268"(DNA unwinding involved in DNA replication)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0006271"(DNA strand elongation involved in DNA replication)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008283"(cell population proliferation)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR008050(MCM protein 7)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|interpro:IPR018525|interpro:IPR027417|interpro:IPR027925|interpro:IPR031327|interpro:IPR033762|interpro:IPR041562|mint:P33993|rcsb pdb:6XTX|rcsb pdb:6XTY|reactome:R-HSA-176187|reactome:R-HSA-176974|reactome:R-HSA-68867|reactome:R-HSA-68949|reactome:R-HSA-68962|reactome:R-HSA-69052|dip:DIP-27580N	-	-	-	figure legend:f1a sf1a|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:7111(trini-high_5)|taxid:7111(Trichoplusia ni cell line from eggs)	-	2013/11/27	2014/10/16	rogid:8mXHWwvrQneZZArPvAEj1JZwOrg9606	rogid:hrpCntkzdVgewNA+/iPS6b50dGY9606	intact-crc:E965765770955DE5|rigid:/bKY5xRGT9a1oR7fOgNUNO67qHU	false	flag tag:?-?	his tag:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P25205	uniprotkb:Q9BTE3	intact:EBI-355153|uniprotkb:B4DWW4|uniprotkb:Q92660|uniprotkb:Q9BTR3|uniprotkb:Q9NUE7|ensembl:ENSP00000472940	intact:EBI-749378|uniprotkb:Q6IA56|uniprotkb:Q9BVT9|uniprotkb:Q9H916|uniprotkb:B3KSP7|ensembl:ENSP00000353098	psi-mi:mcm3_human(display_long)|uniprotkb:MCM3(gene name)|psi-mi:MCM3(display_short)|uniprotkb:DNA polymerase alpha holoenzyme-associated protein P1(gene name synonym)|uniprotkb:RLF subunit beta(gene name synonym)|uniprotkb:p102(gene name synonym)|uniprotkb:P1-MCM3(gene name synonym)	psi-mi:mcmbp_human(display_long)|uniprotkb:MCMBP(gene name)|psi-mi:MCMBP(display_short)|uniprotkb:C10orf119(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Kusunoki et al. (2013)	pubmed:24299456|imex:IM-22017	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-9002734|imex:IM-22017-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002379.3|refseq:NP_001257401.1|ensembl:ENSG00000112118(gene)|ensembl:ENST00000596288(transcript)|go:"GO:0000727"(double-strand break repair via break-induced replication)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003677"(DNA binding)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005658"("alpha DNA polymerase:primase complex")|go:"GO:0005813"(centrosome)|go:"GO:0006267"(pre-replicative complex assembly involved in nuclear cell cycle DNA replication)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0006271"(DNA strand elongation involved in DNA replication)|go:"GO:0016020"(membrane)|go:"GO:0042555"(MCM complex)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0071162"(CMG complex)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1902975"(mitotic DNA replication initiation)|interpro:IPR001208(MCM)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR008046(MCM protein 3)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|interpro:IPR018525|interpro:IPR027417|interpro:IPR027925|interpro:IPR031327|interpro:IPR033762|interpro:IPR041562|mint:P25205|rcsb pdb:6XTX|rcsb pdb:6XTY|reactome:R-HSA-176187|reactome:R-HSA-176974|reactome:R-HSA-68867|reactome:R-HSA-68949|reactome:R-HSA-68962|reactome:R-HSA-69052|dip:DIP-31726N	refseq:NP_079110.1|refseq:NP_001243307.1|refseq:NP_001243308.1|ensembl:ENSG00000197771(gene)|ensembl:ENST00000360003(transcript)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006261"(DNA-dependent DNA replication)|go:"GO:0007062"(sister chromatid cohesion)|go:"GO:0030054"(cell junction)|go:"GO:0051301"(cell division)|interpro:IPR019140|rcsb pdb:4KG9	-	-	-	figure legend:sf1a|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:7111(trini-high_5)|taxid:7111(Trichoplusia ni cell line from eggs)	-	2013/11/27	2014/10/16	rogid:pKYSPG/QbSyVVJtZamU5lVjgIGo9606	rogid:8mXHWwvrQneZZArPvAEj1JZwOrg9606	intact-crc:F89CE687913043AE|rigid:ATR5kj230W1vzoYsA7iVif16d4c	false	-	flag tag:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9BTE3	uniprotkb:Q14566	intact:EBI-749378|uniprotkb:Q6IA56|uniprotkb:Q9BVT9|uniprotkb:Q9H916|uniprotkb:B3KSP7|ensembl:ENSP00000353098	intact:EBI-374900|uniprotkb:Q13504|uniprotkb:Q99859|uniprotkb:B2R6H2|ensembl:ENSP00000264156	psi-mi:mcmbp_human(display_long)|uniprotkb:MCMBP(gene name)|psi-mi:MCMBP(display_short)|uniprotkb:C10orf119(gene name synonym)	psi-mi:mcm6_human(display_long)|uniprotkb:MCM6(gene name)|psi-mi:MCM6(display_short)|uniprotkb:p105MCM(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Kusunoki et al. (2013)	pubmed:24299456|imex:IM-22017	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8875856|imex:IM-22017-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_079110.1|refseq:NP_001243307.1|refseq:NP_001243308.1|ensembl:ENSG00000197771(gene)|ensembl:ENST00000360003(transcript)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006261"(DNA-dependent DNA replication)|go:"GO:0007062"(sister chromatid cohesion)|go:"GO:0030054"(cell junction)|go:"GO:0051301"(cell division)|interpro:IPR019140|rcsb pdb:4KG9	ensembl:ENST00000264156(transcript)|go:"GO:0000727"(double-strand break repair via break-induced replication)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006260"(DNA replication)|go:"GO:0006267"(pre-replicative complex assembly involved in nuclear cell cycle DNA replication)|go:"GO:0006268"(DNA unwinding involved in DNA replication)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0042555"(MCM complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0071162"(CMG complex)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1902969"(mitotic DNA replication)|ensembl:ENSG00000076003(gene)|reactome:R-HSA-68962|reactome:R-HSA-69052|interpro:IPR008049(MCM protein 6)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|interpro:IPR018525|interpro:IPR027417|interpro:IPR027925|interpro:IPR031327|interpro:IPR033762|interpro:IPR041024|interpro:IPR041562|interpro:IPR001208(MCM)|mint:Q14566|rcsb pdb:2KLQ|rcsb pdb:2LE8|rcsb pdb:6XTX|rcsb pdb:6XTY|reactome:R-HSA-176187|reactome:R-HSA-176974|reactome:R-HSA-68867|reactome:R-HSA-68949|refseq:NP_005906.2|dip:DIP-31727N	-	-	-	figure legend:f1b sf1a|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:7111(trini-high_5)|taxid:7111(Trichoplusia ni cell line from eggs)	-	2013/11/27	2014/10/16	rogid:8mXHWwvrQneZZArPvAEj1JZwOrg9606	rogid:gVpEwgfSwwxvP2T2CvCzIukthY49606	intact-crc:62C8D5BDCAFC6BC7|rigid:ErrExehY0q6whP1sy1vQYpfOng4	false	-	myc tag:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9BTE3	uniprotkb:Q9BRT9	intact:EBI-749378|uniprotkb:Q6IA56|uniprotkb:Q9BVT9|uniprotkb:Q9H916|uniprotkb:B3KSP7|ensembl:ENSP00000353098	intact:EBI-747500|uniprotkb:Q8N648|uniprotkb:B2R8H5|uniprotkb:D3DSY0|ensembl:ENSP00000276533|ensembl:ENSP00000428754	psi-mi:mcmbp_human(display_long)|uniprotkb:MCMBP(gene name)|psi-mi:MCMBP(display_short)|uniprotkb:C10orf119(gene name synonym)	psi-mi:sld5_human(display_long)|uniprotkb:SLD5(gene name synonym)|uniprotkb:GINS complex subunit 4(gene name synonym)|uniprotkb:GINS4(gene name)|psi-mi:GINS4(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Kusunoki et al. (2013)	pubmed:24299456|imex:IM-22017	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-9002800|imex:IM-22017-13	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_079110.1|refseq:NP_001243307.1|refseq:NP_001243308.1|ensembl:ENSG00000197771(gene)|ensembl:ENST00000360003(transcript)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006261"(DNA-dependent DNA replication)|go:"GO:0007062"(sister chromatid cohesion)|go:"GO:0030054"(cell junction)|go:"GO:0051301"(cell division)|interpro:IPR019140|rcsb pdb:4KG9	refseq:NP_115712.1|refseq:XP_005273716.1|dip:DIP-29334N|ensembl:ENSG00000147536(gene)|ensembl:ENST00000276533(transcript)|ensembl:ENST00000518671(transcript)|go:"GO:0000727"(double-strand break repair via break-induced replication)|go:"GO:0000811"(GINS complex)|go:"GO:0001833"(inner cell mass cell proliferation)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006261"(DNA-dependent DNA replication)|go:"GO:0071162"(CMG complex)|interpro:IPR008591(GINS complex, Sld5 component)|interpro:IPR021151|interpro:IPR031633|interpro:IPR036224|interpro:IPR038749|mint:Q9BRT9|rcsb pdb:2E9X|rcsb pdb:2EHO|rcsb pdb:2Q9Q|rcsb pdb:6XTX|rcsb pdb:6XTY|reactome:R-HSA-176974	-	-	-	figure legend:sf1b|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:7111(trini-high_5)|taxid:7111(Trichoplusia ni cell line from eggs)	-	2013/11/27	2014/10/16	rogid:8mXHWwvrQneZZArPvAEj1JZwOrg9606	rogid:DL/sJVWAbcV57zkjNgnsQ5acRi09606	intact-crc:A9E10AF6A649560B|rigid:otKXuAVuKVCLgoaC2ZWR4airo9E	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9BTE3	uniprotkb:O00311	intact:EBI-749378|uniprotkb:Q6IA56|uniprotkb:Q9BVT9|uniprotkb:Q9H916|uniprotkb:B3KSP7|ensembl:ENSP00000353098	intact:EBI-374980|uniprotkb:O00558|uniprotkb:Q5T5U5|ensembl:ENSP00000234626|ensembl:ENSP00000393139|uniprotkb:D3DT31	psi-mi:mcmbp_human(display_long)|uniprotkb:MCMBP(gene name)|psi-mi:MCMBP(display_short)|uniprotkb:C10orf119(gene name synonym)	psi-mi:cdc7_human(display_long)|uniprotkb:CDC7(gene name)|psi-mi:CDC7(display_short)|uniprotkb:CDC7L1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Kusunoki et al. (2013)	pubmed:24299456|imex:IM-22017	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-9002775|imex:IM-22017-11	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_079110.1|refseq:NP_001243307.1|refseq:NP_001243308.1|ensembl:ENSG00000197771(gene)|ensembl:ENST00000360003(transcript)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006261"(DNA-dependent DNA replication)|go:"GO:0007062"(sister chromatid cohesion)|go:"GO:0030054"(cell junction)|go:"GO:0051301"(cell division)|interpro:IPR019140|rcsb pdb:4KG9	rcsb pdb:5UWR|rcsb pdb:6YA6|rcsb pdb:6YA7|rcsb pdb:6YA8|reactome:R-HSA-176187|reactome:R-HSA-68962|reactome:R-HSA-8953750|go:"GO:0010971"(positive regulation of G2/M transition of mitotic cell cycle)|go:"GO:0016301"(kinase activity)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0044770"(cell cycle phase transition)|go:"GO:0045171"(intercellular bridge)|go:"GO:0046872"(metal ion binding)|go:"GO:0051301"(cell division)|go:"GO:0072686"(mitotic spindle)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:O00311|rcsb pdb:4F99|rcsb pdb:4F9A|rcsb pdb:4F9B|rcsb pdb:4F9C|rcsb pdb:5UWQ|ensembl:ENSG00000097046(gene)|ensembl:ENST00000234626(transcript)|ensembl:ENST00000428239(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0000727"(double-strand break repair via break-induced replication)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010571"(positive regulation of nuclear cell cycle DNA replication)|refseq:NP_001127891.1|refseq:NP_001127892.1|refseq:NP_003494.1|refseq:XP_005271298.1|dip:DIP-31728N	-	-	-	figure legend:sf1b|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:7111(trini-high_5)|taxid:7111(Trichoplusia ni cell line from eggs)	-	2013/11/27	2014/10/16	rogid:8mXHWwvrQneZZArPvAEj1JZwOrg9606	rogid:p5yHRwdn0crHmH8EXAFyM5R0xwM9606	intact-crc:683912D2DE3A88AD|rigid:JYmvZNJVx8FECul8cAqLGQ6UKqk	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9BTE3	uniprotkb:Q9UQE7	intact:EBI-749378|uniprotkb:Q6IA56|uniprotkb:Q9BVT9|uniprotkb:Q9H916|uniprotkb:B3KSP7|ensembl:ENSP00000353098	intact:EBI-80718|ensembl:ENSP00000354720|uniprotkb:O60464|uniprotkb:Q5T482|uniprotkb:A8K156	psi-mi:mcmbp_human(display_long)|uniprotkb:MCMBP(gene name)|psi-mi:MCMBP(display_short)|uniprotkb:C10orf119(gene name synonym)	psi-mi:smc3_human(display_long)|uniprotkb:SMC3(gene name)|psi-mi:SMC3(display_short)|uniprotkb:BAM(gene name synonym)|uniprotkb:SMC3L1(gene name synonym)|uniprotkb:Chondroitin sulfate proteoglycan 6(gene name synonym)|uniprotkb:Chromosome-associated polypeptide(gene name synonym)|uniprotkb:Basement membrane-associated chondroitin proteoglycan(gene name synonym)|uniprotkb:BMH(gene name synonym)|uniprotkb:CSPG6(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Kusunoki et al. (2013)	pubmed:24299456|imex:IM-22017	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-9002785|imex:IM-22017-12	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_079110.1|refseq:NP_001243307.1|refseq:NP_001243308.1|ensembl:ENSG00000197771(gene)|ensembl:ENST00000360003(transcript)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006261"(DNA-dependent DNA replication)|go:"GO:0007062"(sister chromatid cohesion)|go:"GO:0030054"(cell junction)|go:"GO:0051301"(cell division)|interpro:IPR019140|rcsb pdb:4KG9	go:"GO:0090307"(mitotic spindle assembly)|go:"GO:0097431"(mitotic spindle pole)|interpro:IPR003395(RecF/RecN/SMC protein, N-terminal)|interpro:IPR010935(SMCs flexible hinge)|interpro:IPR024704|interpro:IPR027417|interpro:IPR036277|interpro:IPR041741|mint:Q9UQE7|rcsb pdb:6WG3|rcsb pdb:6WG4|rcsb pdb:6WG6|rcsb pdb:6WGE|reactome:R-HSA-1221632|reactome:R-HSA-2467813|reactome:R-HSA-2468052|reactome:R-HSA-2470946|reactome:R-HSA-2500257|reactome:R-HSA-3108214|reactome:R-HSA-9018519|go:"GO:0070840"(dynein complex binding)|ensembl:ENSG00000108055(gene)|ensembl:ENST00000361804(transcript)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0000785"(chromatin)|go:"GO:0000800"(lateral element)|go:"GO:0003682"(chromatin binding)|go:"GO:0003777"(microtubule motor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005829"(cytosol)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006281"(DNA repair)|go:"GO:0007062"(sister chromatid cohesion)|go:"GO:0008278"(cohesin complex)|go:"GO:0016363"(nuclear matrix)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0030893"(meiotic cohesin complex)|go:"GO:0034991"(nuclear meiotic cohesin complex)|go:"GO:0036033"(mediator complex binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048487"(beta-tubulin binding)|go:"GO:0051301"(cell division)|go:"GO:0051321"(meiotic cell cycle)|refseq:NP_005436.1|dip:DIP-29200N	-	-	-	figure legend:sf1b|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:7111(trini-high_5)|taxid:7111(Trichoplusia ni cell line from eggs)	-	2013/11/27	2014/10/16	rogid:8mXHWwvrQneZZArPvAEj1JZwOrg9606	rogid:pUxr+sTtttRzGlqCRz/25woNtrg9606	intact-crc:835BE6AA696DE88D|rigid:QBOj0bz3cXUXBlunR802MbhluOI	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9BTE3	uniprotkb:Q9UJA3	intact:EBI-749378|uniprotkb:Q6IA56|uniprotkb:Q9BVT9|uniprotkb:Q9H916|uniprotkb:B3KSP7|ensembl:ENSP00000353098	intact:EBI-8756095|uniprotkb:B2RBG7|uniprotkb:D3DW08|uniprotkb:E7EQU7|uniprotkb:Q495R4|uniprotkb:Q495R6|uniprotkb:Q495R7|uniprotkb:Q86US4|uniprotkb:Q969I5|ensembl:ENSP00000368174|ensembl:ENSP00000478141	psi-mi:mcmbp_human(display_long)|uniprotkb:MCMBP(gene name)|psi-mi:MCMBP(display_short)|uniprotkb:C10orf119(gene name synonym)	psi-mi:mcm8_human(display_long)|uniprotkb:MCM8(gene name)|psi-mi:MCM8(display_short)|uniprotkb:C20orf154(gene name synonym)|uniprotkb:Minichromosome maintenance 8(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Kusunoki et al. (2013)	pubmed:24299456|imex:IM-22017	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-9002761|imex:IM-22017-10	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_079110.1|refseq:NP_001243307.1|refseq:NP_001243308.1|ensembl:ENSG00000197771(gene)|ensembl:ENST00000360003(transcript)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006261"(DNA-dependent DNA replication)|go:"GO:0007062"(sister chromatid cohesion)|go:"GO:0030054"(cell junction)|go:"GO:0051301"(cell division)|interpro:IPR019140|rcsb pdb:4KG9	refseq:XP_016883594.1|refseq:NP_115874.3|refseq:NP_877954.1|refseq:NP_001268449.1|refseq:NP_001268450.1|refseq:NP_001268451.1|ensembl:ENST00000378896(transcript)|ensembl:ENST00000610722(transcript)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0003682"(chromatin binding)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|ensembl:ENSG00000125885(gene)|go:"GO:0005829"(cytosol)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007049"(cell cycle)|go:"GO:0007292"(female gamete generation)|go:"GO:0019899"(enzyme binding)|go:"GO:0032406"(MutLbeta complex binding)|go:"GO:0032407"(MutSalpha complex binding)|go:"GO:0032408"(MutSbeta complex binding)|go:"GO:0036298"(recombinational interstrand cross-link repair)|go:"GO:0042555"(MCM complex)|go:"GO:0048232"(male gamete generation)|go:"GO:0050821"(protein stabilization)|go:"GO:0071168"(protein localization to chromatin)|go:"GO:0097362"(MCM8-MCM9 complex)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR001208(MCM)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|interpro:IPR027417|interpro:IPR031327|interpro:IPR033762|interpro:IPR041562|mint:Q9UJA3|rcsb pdb:6L0O|rcsb pdb:7DP3|reactome:R-HSA-113507|reactome:R-HSA-176187|reactome:R-HSA-176974|reactome:R-HSA-68689|reactome:R-HSA-68827|reactome:R-HSA-68867|reactome:R-HSA-68949|reactome:R-HSA-68962	-	-	-	figure legend:sf1a|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:7111(trini-high_5)|taxid:7111(Trichoplusia ni cell line from eggs)	-	2013/11/27	2014/10/16	rogid:8mXHWwvrQneZZArPvAEj1JZwOrg9606	rogid:po4hzJ/+5JWxog5BnKAfHYKmE7w9606	intact-crc:683BC2D2DE3A88AD|rigid:PdDkkTf4aniHwMn64/CBAQD4CM0	false	flag tag:?-?	his tag:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P33991	uniprotkb:P33993	intact:EBI-374938|uniprotkb:Q8NEH1|uniprotkb:Q99658|ensembl:ENSP00000262105|ensembl:ENSP00000496964	intact:EBI-355924|uniprotkb:Q15076|uniprotkb:Q96D34|uniprotkb:Q96GL1|uniprotkb:A4D2A1|uniprotkb:A4D2A2|uniprotkb:E9PGN9|ensembl:ENSP00000307288	psi-mi:mcm4_human(display_long)|uniprotkb:MCM4(gene name)|psi-mi:MCM4(display_short)|uniprotkb:CDC21(gene name synonym)|uniprotkb:CDC21 homolog(gene name synonym)|uniprotkb:P1-CDC21(gene name synonym)	psi-mi:mcm7_human(display_long)|uniprotkb:MCM7(gene name)|psi-mi:MCM7(display_short)|uniprotkb:CDC47(gene name synonym)|uniprotkb:MCM2(gene name synonym)|uniprotkb:CDC47 homolog(gene name synonym)|uniprotkb:P1.1-MCM3(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Kusunoki et al. (2013)	pubmed:24299456|imex:IM-22017	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8875866|imex:IM-22017-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005905.2|refseq:NP_877423.1|ensembl:ENSG00000104738(gene)|ensembl:ENST00000262105(transcript)|ensembl:ENST00000649973(transcript)|go:"GO:0000727"(double-strand break repair via break-induced replication)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006260"(DNA replication)|go:"GO:0006267"(pre-replicative complex assembly involved in nuclear cell cycle DNA replication)|go:"GO:0006268"(DNA unwinding involved in DNA replication)|go:"GO:0006271"(DNA strand elongation involved in DNA replication)|go:"GO:0016020"(membrane)|go:"GO:0042555"(MCM complex)|go:"GO:0071162"(CMG complex)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1902975"(mitotic DNA replication initiation)|interpro:IPR001208(MCM)|interpro:IPR008047(MCM protein 4)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|interpro:IPR018525|interpro:IPR027417|interpro:IPR027925|interpro:IPR031327|interpro:IPR033762|interpro:IPR041562|mint:P33991|rcsb pdb:6XTX|rcsb pdb:6XTY|reactome:R-HSA-176187|reactome:R-HSA-176974|reactome:R-HSA-68867|reactome:R-HSA-68949|reactome:R-HSA-68962|reactome:R-HSA-69052|dip:DIP-31729N	refseq:NP_001265524.1|refseq:NP_005907.3|refseq:NP_877577.1|ensembl:ENSG00000166508(gene)|ensembl:ENST00000303887(transcript)|go:"GO:0000727"(double-strand break repair via break-induced replication)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000785"(chromatin)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0016020"(membrane)|go:"GO:0042325"(regulation of phosphorylation)|go:"GO:0042493"|go:"GO:0042555"(MCM complex)|go:"GO:0071162"(CMG complex)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0071466"(cellular response to xenobiotic stimulus)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR001208(MCM)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006260"(DNA replication)|go:"GO:0006267"(pre-replicative complex assembly involved in nuclear cell cycle DNA replication)|go:"GO:0006268"(DNA unwinding involved in DNA replication)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0006271"(DNA strand elongation involved in DNA replication)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008283"(cell population proliferation)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR008050(MCM protein 7)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|interpro:IPR018525|interpro:IPR027417|interpro:IPR027925|interpro:IPR031327|interpro:IPR033762|interpro:IPR041562|mint:P33993|rcsb pdb:6XTX|rcsb pdb:6XTY|reactome:R-HSA-176187|reactome:R-HSA-176974|reactome:R-HSA-68867|reactome:R-HSA-68949|reactome:R-HSA-68962|reactome:R-HSA-69052|dip:DIP-27580N	-	-	-	figure legend:f1a|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:7111(trini-high_5)|taxid:7111(Trichoplusia ni cell line from eggs)	-	2013/11/27	2014/10/16	rogid:emFkamsHmwBPzoJnPcaL4SaqAlU9606	rogid:hrpCntkzdVgewNA+/iPS6b50dGY9606	intact-crc:98815A93E4474E2A|rigid:6QPTrHhwiJq2eX3IATw+nSW6WUc	false	his tag:?-?	his tag:?-?|binding-associated region:1-329	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9BTE3	uniprotkb:Q9UQE7	intact:EBI-749378|uniprotkb:Q6IA56|uniprotkb:Q9BVT9|uniprotkb:Q9H916|uniprotkb:B3KSP7|ensembl:ENSP00000353098	intact:EBI-80718|ensembl:ENSP00000354720|uniprotkb:O60464|uniprotkb:Q5T482|uniprotkb:A8K156	psi-mi:mcmbp_human(display_long)|uniprotkb:MCMBP(gene name)|psi-mi:MCMBP(display_short)|uniprotkb:C10orf119(gene name synonym)	psi-mi:smc3_human(display_long)|uniprotkb:SMC3(gene name)|psi-mi:SMC3(display_short)|uniprotkb:BAM(gene name synonym)|uniprotkb:SMC3L1(gene name synonym)|uniprotkb:Chondroitin sulfate proteoglycan 6(gene name synonym)|uniprotkb:Chromosome-associated polypeptide(gene name synonym)|uniprotkb:Basement membrane-associated chondroitin proteoglycan(gene name synonym)|uniprotkb:BMH(gene name synonym)|uniprotkb:CSPG6(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Kusunoki et al. (2013)	pubmed:24299456|imex:IM-22017	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8875903|imex:IM-22017-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_079110.1|refseq:NP_001243307.1|refseq:NP_001243308.1|ensembl:ENSG00000197771(gene)|ensembl:ENST00000360003(transcript)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006261"(DNA-dependent DNA replication)|go:"GO:0007062"(sister chromatid cohesion)|go:"GO:0030054"(cell junction)|go:"GO:0051301"(cell division)|interpro:IPR019140|rcsb pdb:4KG9	go:"GO:0090307"(mitotic spindle assembly)|go:"GO:0097431"(mitotic spindle pole)|interpro:IPR003395(RecF/RecN/SMC protein, N-terminal)|interpro:IPR010935(SMCs flexible hinge)|interpro:IPR024704|interpro:IPR027417|interpro:IPR036277|interpro:IPR041741|mint:Q9UQE7|rcsb pdb:6WG3|rcsb pdb:6WG4|rcsb pdb:6WG6|rcsb pdb:6WGE|reactome:R-HSA-1221632|reactome:R-HSA-2467813|reactome:R-HSA-2468052|reactome:R-HSA-2470946|reactome:R-HSA-2500257|reactome:R-HSA-3108214|reactome:R-HSA-9018519|go:"GO:0070840"(dynein complex binding)|ensembl:ENSG00000108055(gene)|ensembl:ENST00000361804(transcript)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0000785"(chromatin)|go:"GO:0000800"(lateral element)|go:"GO:0003682"(chromatin binding)|go:"GO:0003777"(microtubule motor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005829"(cytosol)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006281"(DNA repair)|go:"GO:0007062"(sister chromatid cohesion)|go:"GO:0008278"(cohesin complex)|go:"GO:0016363"(nuclear matrix)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0030893"(meiotic cohesin complex)|go:"GO:0034991"(nuclear meiotic cohesin complex)|go:"GO:0036033"(mediator complex binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048487"(beta-tubulin binding)|go:"GO:0051301"(cell division)|go:"GO:0051321"(meiotic cell cycle)|refseq:NP_005436.1|dip:DIP-29200N	-	-	-	figure legend:f2|comment:"Cell lysate was prepared from unsynchronized HeLa cells in the  presence of 100 mM NaCl, and MCM-BP in Triton-soluble fraction was  immuno-precipitated with anti-MCM-BP antibody bound to protein G (Fig. 2A). With  precipitation of MCM-BP, co-precipitation of MCM3, MCM4, MCM5, MCM6 and  MCM7 was detected, and these results are consistent with those reported earlier (20). In  addition to MCM3-7, co-precipitation of SMC3 and ORC3 was newly detected. These  results are essentially consistent with those obtained by immuno-precipitation using the  co-expressed insect cell lysate. Thus it is probable that these proteins directly interact  with MCM-BP in HeLa cells."|comment:"First, immuno-precipitation was performed using HeLa  cells at early S phase (Fig. 2B). With precipitation of MCM-BP, co-precipitation of  MCM5 and MCM7 was detected. Faint bands of MCM4 and SMC3 proteins were  detected in the precipitate.  Next, immuno-precipitation was carried out using lysate of HeLa cells  synchronized at G2 phase (Fig. 2C). With precipitation of MCM-BP, co-precipitation of  MCM7 and SMC3 was detected. Faint band of MCM5 was detected."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells)	-	2013/11/27	2014/10/16	rogid:8mXHWwvrQneZZArPvAEj1JZwOrg9606	rogid:pUxr+sTtttRzGlqCRz/25woNtrg9606	intact-crc:A1DF9AD7859A7617|rigid:tS+myabJMEcedOM/gvyHIK58YUc	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9BTE3	uniprotkb:P33992	intact:EBI-749378|uniprotkb:Q6IA56|uniprotkb:Q9BVT9|uniprotkb:Q9H916|uniprotkb:B3KSP7|ensembl:ENSP00000353098	intact:EBI-359410|ensembl:ENSP00000216122|uniprotkb:O60785|uniprotkb:Q14578|uniprotkb:Q9BTJ4|uniprotkb:Q9BWL8	psi-mi:mcmbp_human(display_long)|uniprotkb:MCMBP(gene name)|psi-mi:MCMBP(display_short)|uniprotkb:C10orf119(gene name synonym)	psi-mi:mcm5_human(display_long)|uniprotkb:MCM5(gene name)|psi-mi:MCM5(display_short)|uniprotkb:CDC46(gene name synonym)|uniprotkb:CDC46 homolog(gene name synonym)|uniprotkb:P1-CDC46(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Kusunoki et al. (2013)	pubmed:24299456|imex:IM-22017	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8875903|imex:IM-22017-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_079110.1|refseq:NP_001243307.1|refseq:NP_001243308.1|ensembl:ENSG00000197771(gene)|ensembl:ENST00000360003(transcript)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006261"(DNA-dependent DNA replication)|go:"GO:0007062"(sister chromatid cohesion)|go:"GO:0030054"(cell junction)|go:"GO:0051301"(cell division)|interpro:IPR019140|rcsb pdb:4KG9	ensembl:ENSG00000100297(gene)|ensembl:ENST00000216122(transcript)|go:"GO:0000727"(double-strand break repair via break-induced replication)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006260"(DNA replication)|go:"GO:0006267"(pre-replicative complex assembly involved in nuclear cell cycle DNA replication)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0016020"(membrane)|go:"GO:0042555"(MCM complex)|go:"GO:0071162"(CMG complex)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR001208(MCM)|interpro:IPR008048(MCM protein 5)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|interpro:IPR018525|interpro:IPR027417|interpro:IPR027925|interpro:IPR031327|interpro:IPR033762|interpro:IPR041562|mint:P33992|rcsb pdb:6XTX|rcsb pdb:6XTY|reactome:R-HSA-176187|reactome:R-HSA-176974|reactome:R-HSA-68867|reactome:R-HSA-68949|refseq:NP_006730.2|reactome:R-HSA-69052|reactome:R-HSA-68962|dip:DIP-27578N	-	-	-	figure legend:f2|comment:"Cell lysate was prepared from unsynchronized HeLa cells in the  presence of 100 mM NaCl, and MCM-BP in Triton-soluble fraction was  immuno-precipitated with anti-MCM-BP antibody bound to protein G (Fig. 2A). With  precipitation of MCM-BP, co-precipitation of MCM3, MCM4, MCM5, MCM6 and  MCM7 was detected, and these results are consistent with those reported earlier (20). In  addition to MCM3-7, co-precipitation of SMC3 and ORC3 was newly detected. These  results are essentially consistent with those obtained by immuno-precipitation using the  co-expressed insect cell lysate. Thus it is probable that these proteins directly interact  with MCM-BP in HeLa cells."|comment:"First, immuno-precipitation was performed using HeLa  cells at early S phase (Fig. 2B). With precipitation of MCM-BP, co-precipitation of  MCM5 and MCM7 was detected. Faint bands of MCM4 and SMC3 proteins were  detected in the precipitate.  Next, immuno-precipitation was carried out using lysate of HeLa cells  synchronized at G2 phase (Fig. 2C). With precipitation of MCM-BP, co-precipitation of  MCM7 and SMC3 was detected. Faint band of MCM5 was detected."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells)	-	2013/11/27	2014/10/16	rogid:8mXHWwvrQneZZArPvAEj1JZwOrg9606	rogid:WjJ4lSpADQFtwT0WnumbRHl/lPw9606	intact-crc:A1DF9AD7859A7617|rigid:tS+myabJMEcedOM/gvyHIK58YUc	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9BTE3	uniprotkb:Q9UBD5	intact:EBI-749378|uniprotkb:Q6IA56|uniprotkb:Q9BVT9|uniprotkb:Q9H916|uniprotkb:B3KSP7|ensembl:ENSP00000353098	intact:EBI-374916|uniprotkb:A2A2T5|uniprotkb:Q13565|uniprotkb:Q53GY6|uniprotkb:Q5T159|uniprotkb:Q6IUY7|uniprotkb:Q86TN5|uniprotkb:Q9UG44|uniprotkb:Q9UNT6|ensembl:ENSP00000376586|uniprotkb:B4E025	psi-mi:mcmbp_human(display_long)|uniprotkb:MCMBP(gene name)|psi-mi:MCMBP(display_short)|uniprotkb:C10orf119(gene name synonym)	psi-mi:orc3_human(display_long)|uniprotkb:ORC3(gene name)|psi-mi:ORC3(display_short)|uniprotkb:LATHEO(gene name synonym)|uniprotkb:Origin recognition complex subunit Latheo(gene name synonym)|uniprotkb:ORC3L(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Kusunoki et al. (2013)	pubmed:24299456|imex:IM-22017	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8875903|imex:IM-22017-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_079110.1|refseq:NP_001243307.1|refseq:NP_001243308.1|ensembl:ENSG00000197771(gene)|ensembl:ENST00000360003(transcript)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006261"(DNA-dependent DNA replication)|go:"GO:0007062"(sister chromatid cohesion)|go:"GO:0030054"(cell junction)|go:"GO:0051301"(cell division)|interpro:IPR019140|rcsb pdb:4KG9	go:"GO:0000808"(origin recognition complex)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005656"(nuclear pre-replicative complex)|go:"GO:0005664"(nuclear origin of replication recognition complex)|go:"GO:0006260"(DNA replication)|go:"GO:0006267"(pre-replicative complex assembly involved in nuclear cell cycle DNA replication)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0016604"(nuclear body)|go:"GO:0031261"(DNA replication preinitiation complex)|go:"GO:0061351"(neural precursor cell proliferation)|interpro:IPR020795|interpro:IPR040855|rcsb pdb:5UJ8|rcsb pdb:5UJM|rcsb pdb:7CTE|rcsb pdb:7CTF|go:"GO:0000785"(chromatin)|rcsb pdb:7CTG|rcsb pdb:7JPO|rcsb pdb:7JPP|rcsb pdb:7JPQ|ensembl:ENSG00000135336(gene)|ensembl:ENST00000392844(transcript)|go:"GO:0000781"(chromosome, telomeric region)|rcsb pdb:7JPS|reactome:R-HSA-113507|reactome:R-HSA-176187|rcsb pdb:7JPR|reactome:R-HSA-68616|reactome:R-HSA-68689|reactome:R-HSA-68827|reactome:R-HSA-68867|reactome:R-HSA-68949|reactome:R-HSA-68962|refseq:NP_036513.2|refseq:NP_862820.1|refseq:NP_001184188.1|dip:DIP-31735N	-	-	-	figure legend:f2|comment:"Cell lysate was prepared from unsynchronized HeLa cells in the  presence of 100 mM NaCl, and MCM-BP in Triton-soluble fraction was  immuno-precipitated with anti-MCM-BP antibody bound to protein G (Fig. 2A). With  precipitation of MCM-BP, co-precipitation of MCM3, MCM4, MCM5, MCM6 and  MCM7 was detected, and these results are consistent with those reported earlier (20). In  addition to MCM3-7, co-precipitation of SMC3 and ORC3 was newly detected. These  results are essentially consistent with those obtained by immuno-precipitation using the  co-expressed insect cell lysate. Thus it is probable that these proteins directly interact  with MCM-BP in HeLa cells."|comment:"First, immuno-precipitation was performed using HeLa  cells at early S phase (Fig. 2B). With precipitation of MCM-BP, co-precipitation of  MCM5 and MCM7 was detected. Faint bands of MCM4 and SMC3 proteins were  detected in the precipitate.  Next, immuno-precipitation was carried out using lysate of HeLa cells  synchronized at G2 phase (Fig. 2C). With precipitation of MCM-BP, co-precipitation of  MCM7 and SMC3 was detected. Faint band of MCM5 was detected."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells)	-	2013/11/27	2014/10/16	rogid:8mXHWwvrQneZZArPvAEj1JZwOrg9606	rogid:ldvEZZ/fRPP3yHQJJIhf0zxYeLM9606	intact-crc:A1DF9AD7859A7617|rigid:tS+myabJMEcedOM/gvyHIK58YUc	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9BTE3	uniprotkb:P33991	intact:EBI-749378|uniprotkb:Q6IA56|uniprotkb:Q9BVT9|uniprotkb:Q9H916|uniprotkb:B3KSP7|ensembl:ENSP00000353098	intact:EBI-374938|uniprotkb:Q8NEH1|uniprotkb:Q99658|ensembl:ENSP00000262105|ensembl:ENSP00000496964	psi-mi:mcmbp_human(display_long)|uniprotkb:MCMBP(gene name)|psi-mi:MCMBP(display_short)|uniprotkb:C10orf119(gene name synonym)	psi-mi:mcm4_human(display_long)|uniprotkb:MCM4(gene name)|psi-mi:MCM4(display_short)|uniprotkb:CDC21(gene name synonym)|uniprotkb:CDC21 homolog(gene name synonym)|uniprotkb:P1-CDC21(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Kusunoki et al. (2013)	pubmed:24299456|imex:IM-22017	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8875903|imex:IM-22017-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_079110.1|refseq:NP_001243307.1|refseq:NP_001243308.1|ensembl:ENSG00000197771(gene)|ensembl:ENST00000360003(transcript)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006261"(DNA-dependent DNA replication)|go:"GO:0007062"(sister chromatid cohesion)|go:"GO:0030054"(cell junction)|go:"GO:0051301"(cell division)|interpro:IPR019140|rcsb pdb:4KG9	refseq:NP_005905.2|refseq:NP_877423.1|ensembl:ENSG00000104738(gene)|ensembl:ENST00000262105(transcript)|ensembl:ENST00000649973(transcript)|go:"GO:0000727"(double-strand break repair via break-induced replication)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006260"(DNA replication)|go:"GO:0006267"(pre-replicative complex assembly involved in nuclear cell cycle DNA replication)|go:"GO:0006268"(DNA unwinding involved in DNA replication)|go:"GO:0006271"(DNA strand elongation involved in DNA replication)|go:"GO:0016020"(membrane)|go:"GO:0042555"(MCM complex)|go:"GO:0071162"(CMG complex)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1902975"(mitotic DNA replication initiation)|interpro:IPR001208(MCM)|interpro:IPR008047(MCM protein 4)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|interpro:IPR018525|interpro:IPR027417|interpro:IPR027925|interpro:IPR031327|interpro:IPR033762|interpro:IPR041562|mint:P33991|rcsb pdb:6XTX|rcsb pdb:6XTY|reactome:R-HSA-176187|reactome:R-HSA-176974|reactome:R-HSA-68867|reactome:R-HSA-68949|reactome:R-HSA-68962|reactome:R-HSA-69052|dip:DIP-31729N	-	-	-	figure legend:f2|comment:"Cell lysate was prepared from unsynchronized HeLa cells in the  presence of 100 mM NaCl, and MCM-BP in Triton-soluble fraction was  immuno-precipitated with anti-MCM-BP antibody bound to protein G (Fig. 2A). With  precipitation of MCM-BP, co-precipitation of MCM3, MCM4, MCM5, MCM6 and  MCM7 was detected, and these results are consistent with those reported earlier (20). In  addition to MCM3-7, co-precipitation of SMC3 and ORC3 was newly detected. These  results are essentially consistent with those obtained by immuno-precipitation using the  co-expressed insect cell lysate. Thus it is probable that these proteins directly interact  with MCM-BP in HeLa cells."|comment:"First, immuno-precipitation was performed using HeLa  cells at early S phase (Fig. 2B). With precipitation of MCM-BP, co-precipitation of  MCM5 and MCM7 was detected. Faint bands of MCM4 and SMC3 proteins were  detected in the precipitate.  Next, immuno-precipitation was carried out using lysate of HeLa cells  synchronized at G2 phase (Fig. 2C). With precipitation of MCM-BP, co-precipitation of  MCM7 and SMC3 was detected. Faint band of MCM5 was detected."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells)	-	2013/11/27	2014/10/16	rogid:8mXHWwvrQneZZArPvAEj1JZwOrg9606	rogid:emFkamsHmwBPzoJnPcaL4SaqAlU9606	intact-crc:A1DF9AD7859A7617|rigid:tS+myabJMEcedOM/gvyHIK58YUc	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9BTE3	uniprotkb:P25205	intact:EBI-749378|uniprotkb:Q6IA56|uniprotkb:Q9BVT9|uniprotkb:Q9H916|uniprotkb:B3KSP7|ensembl:ENSP00000353098	intact:EBI-355153|uniprotkb:B4DWW4|uniprotkb:Q92660|uniprotkb:Q9BTR3|uniprotkb:Q9NUE7|ensembl:ENSP00000472940	psi-mi:mcmbp_human(display_long)|uniprotkb:MCMBP(gene name)|psi-mi:MCMBP(display_short)|uniprotkb:C10orf119(gene name synonym)	psi-mi:mcm3_human(display_long)|uniprotkb:MCM3(gene name)|psi-mi:MCM3(display_short)|uniprotkb:DNA polymerase alpha holoenzyme-associated protein P1(gene name synonym)|uniprotkb:RLF subunit beta(gene name synonym)|uniprotkb:p102(gene name synonym)|uniprotkb:P1-MCM3(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Kusunoki et al. (2013)	pubmed:24299456|imex:IM-22017	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8875903|imex:IM-22017-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_079110.1|refseq:NP_001243307.1|refseq:NP_001243308.1|ensembl:ENSG00000197771(gene)|ensembl:ENST00000360003(transcript)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006261"(DNA-dependent DNA replication)|go:"GO:0007062"(sister chromatid cohesion)|go:"GO:0030054"(cell junction)|go:"GO:0051301"(cell division)|interpro:IPR019140|rcsb pdb:4KG9	refseq:NP_002379.3|refseq:NP_001257401.1|ensembl:ENSG00000112118(gene)|ensembl:ENST00000596288(transcript)|go:"GO:0000727"(double-strand break repair via break-induced replication)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003677"(DNA binding)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005658"("alpha DNA polymerase:primase complex")|go:"GO:0005813"(centrosome)|go:"GO:0006267"(pre-replicative complex assembly involved in nuclear cell cycle DNA replication)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0006271"(DNA strand elongation involved in DNA replication)|go:"GO:0016020"(membrane)|go:"GO:0042555"(MCM complex)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0071162"(CMG complex)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1902975"(mitotic DNA replication initiation)|interpro:IPR001208(MCM)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR008046(MCM protein 3)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|interpro:IPR018525|interpro:IPR027417|interpro:IPR027925|interpro:IPR031327|interpro:IPR033762|interpro:IPR041562|mint:P25205|rcsb pdb:6XTX|rcsb pdb:6XTY|reactome:R-HSA-176187|reactome:R-HSA-176974|reactome:R-HSA-68867|reactome:R-HSA-68949|reactome:R-HSA-68962|reactome:R-HSA-69052|dip:DIP-31726N	-	-	-	figure legend:f2|comment:"Cell lysate was prepared from unsynchronized HeLa cells in the  presence of 100 mM NaCl, and MCM-BP in Triton-soluble fraction was  immuno-precipitated with anti-MCM-BP antibody bound to protein G (Fig. 2A). With  precipitation of MCM-BP, co-precipitation of MCM3, MCM4, MCM5, MCM6 and  MCM7 was detected, and these results are consistent with those reported earlier (20). In  addition to MCM3-7, co-precipitation of SMC3 and ORC3 was newly detected. These  results are essentially consistent with those obtained by immuno-precipitation using the  co-expressed insect cell lysate. Thus it is probable that these proteins directly interact  with MCM-BP in HeLa cells."|comment:"First, immuno-precipitation was performed using HeLa  cells at early S phase (Fig. 2B). With precipitation of MCM-BP, co-precipitation of  MCM5 and MCM7 was detected. Faint bands of MCM4 and SMC3 proteins were  detected in the precipitate.  Next, immuno-precipitation was carried out using lysate of HeLa cells  synchronized at G2 phase (Fig. 2C). With precipitation of MCM-BP, co-precipitation of  MCM7 and SMC3 was detected. Faint band of MCM5 was detected."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells)	-	2013/11/27	2014/10/16	rogid:8mXHWwvrQneZZArPvAEj1JZwOrg9606	rogid:pKYSPG/QbSyVVJtZamU5lVjgIGo9606	intact-crc:A1DF9AD7859A7617|rigid:tS+myabJMEcedOM/gvyHIK58YUc	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9BTE3	uniprotkb:P33993	intact:EBI-749378|uniprotkb:Q6IA56|uniprotkb:Q9BVT9|uniprotkb:Q9H916|uniprotkb:B3KSP7|ensembl:ENSP00000353098	intact:EBI-355924|uniprotkb:Q15076|uniprotkb:Q96D34|uniprotkb:Q96GL1|uniprotkb:A4D2A1|uniprotkb:A4D2A2|uniprotkb:E9PGN9|ensembl:ENSP00000307288	psi-mi:mcmbp_human(display_long)|uniprotkb:MCMBP(gene name)|psi-mi:MCMBP(display_short)|uniprotkb:C10orf119(gene name synonym)	psi-mi:mcm7_human(display_long)|uniprotkb:MCM7(gene name)|psi-mi:MCM7(display_short)|uniprotkb:CDC47(gene name synonym)|uniprotkb:MCM2(gene name synonym)|uniprotkb:CDC47 homolog(gene name synonym)|uniprotkb:P1.1-MCM3(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Kusunoki et al. (2013)	pubmed:24299456|imex:IM-22017	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8875903|imex:IM-22017-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_079110.1|refseq:NP_001243307.1|refseq:NP_001243308.1|ensembl:ENSG00000197771(gene)|ensembl:ENST00000360003(transcript)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006261"(DNA-dependent DNA replication)|go:"GO:0007062"(sister chromatid cohesion)|go:"GO:0030054"(cell junction)|go:"GO:0051301"(cell division)|interpro:IPR019140|rcsb pdb:4KG9	refseq:NP_001265524.1|refseq:NP_005907.3|refseq:NP_877577.1|ensembl:ENSG00000166508(gene)|ensembl:ENST00000303887(transcript)|go:"GO:0000727"(double-strand break repair via break-induced replication)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000785"(chromatin)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0016020"(membrane)|go:"GO:0042325"(regulation of phosphorylation)|go:"GO:0042493"|go:"GO:0042555"(MCM complex)|go:"GO:0071162"(CMG complex)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0071466"(cellular response to xenobiotic stimulus)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR001208(MCM)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006260"(DNA replication)|go:"GO:0006267"(pre-replicative complex assembly involved in nuclear cell cycle DNA replication)|go:"GO:0006268"(DNA unwinding involved in DNA replication)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0006271"(DNA strand elongation involved in DNA replication)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008283"(cell population proliferation)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR008050(MCM protein 7)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|interpro:IPR018525|interpro:IPR027417|interpro:IPR027925|interpro:IPR031327|interpro:IPR033762|interpro:IPR041562|mint:P33993|rcsb pdb:6XTX|rcsb pdb:6XTY|reactome:R-HSA-176187|reactome:R-HSA-176974|reactome:R-HSA-68867|reactome:R-HSA-68949|reactome:R-HSA-68962|reactome:R-HSA-69052|dip:DIP-27580N	-	-	-	figure legend:f2|comment:"Cell lysate was prepared from unsynchronized HeLa cells in the  presence of 100 mM NaCl, and MCM-BP in Triton-soluble fraction was  immuno-precipitated with anti-MCM-BP antibody bound to protein G (Fig. 2A). With  precipitation of MCM-BP, co-precipitation of MCM3, MCM4, MCM5, MCM6 and  MCM7 was detected, and these results are consistent with those reported earlier (20). In  addition to MCM3-7, co-precipitation of SMC3 and ORC3 was newly detected. These  results are essentially consistent with those obtained by immuno-precipitation using the  co-expressed insect cell lysate. Thus it is probable that these proteins directly interact  with MCM-BP in HeLa cells."|comment:"First, immuno-precipitation was performed using HeLa  cells at early S phase (Fig. 2B). With precipitation of MCM-BP, co-precipitation of  MCM5 and MCM7 was detected. Faint bands of MCM4 and SMC3 proteins were  detected in the precipitate.  Next, immuno-precipitation was carried out using lysate of HeLa cells  synchronized at G2 phase (Fig. 2C). With precipitation of MCM-BP, co-precipitation of  MCM7 and SMC3 was detected. Faint band of MCM5 was detected."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells)	-	2013/11/27	2014/10/16	rogid:8mXHWwvrQneZZArPvAEj1JZwOrg9606	rogid:hrpCntkzdVgewNA+/iPS6b50dGY9606	intact-crc:A1DF9AD7859A7617|rigid:tS+myabJMEcedOM/gvyHIK58YUc	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9BTE3	uniprotkb:Q14566	intact:EBI-749378|uniprotkb:Q6IA56|uniprotkb:Q9BVT9|uniprotkb:Q9H916|uniprotkb:B3KSP7|ensembl:ENSP00000353098	intact:EBI-374900|uniprotkb:Q13504|uniprotkb:Q99859|uniprotkb:B2R6H2|ensembl:ENSP00000264156	psi-mi:mcmbp_human(display_long)|uniprotkb:MCMBP(gene name)|psi-mi:MCMBP(display_short)|uniprotkb:C10orf119(gene name synonym)	psi-mi:mcm6_human(display_long)|uniprotkb:MCM6(gene name)|psi-mi:MCM6(display_short)|uniprotkb:p105MCM(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Kusunoki et al. (2013)	pubmed:24299456|imex:IM-22017	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8875903|imex:IM-22017-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_079110.1|refseq:NP_001243307.1|refseq:NP_001243308.1|ensembl:ENSG00000197771(gene)|ensembl:ENST00000360003(transcript)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006261"(DNA-dependent DNA replication)|go:"GO:0007062"(sister chromatid cohesion)|go:"GO:0030054"(cell junction)|go:"GO:0051301"(cell division)|interpro:IPR019140|rcsb pdb:4KG9	ensembl:ENST00000264156(transcript)|go:"GO:0000727"(double-strand break repair via break-induced replication)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006260"(DNA replication)|go:"GO:0006267"(pre-replicative complex assembly involved in nuclear cell cycle DNA replication)|go:"GO:0006268"(DNA unwinding involved in DNA replication)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0042555"(MCM complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0071162"(CMG complex)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1902969"(mitotic DNA replication)|ensembl:ENSG00000076003(gene)|reactome:R-HSA-68962|reactome:R-HSA-69052|interpro:IPR008049(MCM protein 6)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|interpro:IPR018525|interpro:IPR027417|interpro:IPR027925|interpro:IPR031327|interpro:IPR033762|interpro:IPR041024|interpro:IPR041562|interpro:IPR001208(MCM)|mint:Q14566|rcsb pdb:2KLQ|rcsb pdb:2LE8|rcsb pdb:6XTX|rcsb pdb:6XTY|reactome:R-HSA-176187|reactome:R-HSA-176974|reactome:R-HSA-68867|reactome:R-HSA-68949|refseq:NP_005906.2|dip:DIP-31727N	-	-	-	figure legend:f2|comment:"Cell lysate was prepared from unsynchronized HeLa cells in the  presence of 100 mM NaCl, and MCM-BP in Triton-soluble fraction was  immuno-precipitated with anti-MCM-BP antibody bound to protein G (Fig. 2A). With  precipitation of MCM-BP, co-precipitation of MCM3, MCM4, MCM5, MCM6 and  MCM7 was detected, and these results are consistent with those reported earlier (20). In  addition to MCM3-7, co-precipitation of SMC3 and ORC3 was newly detected. These  results are essentially consistent with those obtained by immuno-precipitation using the  co-expressed insect cell lysate. Thus it is probable that these proteins directly interact  with MCM-BP in HeLa cells."|comment:"First, immuno-precipitation was performed using HeLa  cells at early S phase (Fig. 2B). With precipitation of MCM-BP, co-precipitation of  MCM5 and MCM7 was detected. Faint bands of MCM4 and SMC3 proteins were  detected in the precipitate.  Next, immuno-precipitation was carried out using lysate of HeLa cells  synchronized at G2 phase (Fig. 2C). With precipitation of MCM-BP, co-precipitation of  MCM7 and SMC3 was detected. Faint band of MCM5 was detected."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells)	-	2013/11/27	2014/10/16	rogid:8mXHWwvrQneZZArPvAEj1JZwOrg9606	rogid:gVpEwgfSwwxvP2T2CvCzIukthY49606	intact-crc:A1DF9AD7859A7617|rigid:tS+myabJMEcedOM/gvyHIK58YUc	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9BTE3	uniprotkb:Q14566	intact:EBI-749378|uniprotkb:Q6IA56|uniprotkb:Q9BVT9|uniprotkb:Q9H916|uniprotkb:B3KSP7|ensembl:ENSP00000353098	intact:EBI-374900|uniprotkb:Q13504|uniprotkb:Q99859|uniprotkb:B2R6H2|ensembl:ENSP00000264156	psi-mi:mcmbp_human(display_long)|uniprotkb:MCMBP(gene name)|psi-mi:MCMBP(display_short)|uniprotkb:C10orf119(gene name synonym)	psi-mi:mcm6_human(display_long)|uniprotkb:MCM6(gene name)|psi-mi:MCM6(display_short)|uniprotkb:p105MCM(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Kusunoki et al. (2013)	pubmed:24299456|imex:IM-22017	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8875990|imex:IM-22017-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_079110.1|refseq:NP_001243307.1|refseq:NP_001243308.1|ensembl:ENSG00000197771(gene)|ensembl:ENST00000360003(transcript)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006261"(DNA-dependent DNA replication)|go:"GO:0007062"(sister chromatid cohesion)|go:"GO:0030054"(cell junction)|go:"GO:0051301"(cell division)|interpro:IPR019140|rcsb pdb:4KG9	ensembl:ENST00000264156(transcript)|go:"GO:0000727"(double-strand break repair via break-induced replication)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006260"(DNA replication)|go:"GO:0006267"(pre-replicative complex assembly involved in nuclear cell cycle DNA replication)|go:"GO:0006268"(DNA unwinding involved in DNA replication)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0042555"(MCM complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0071162"(CMG complex)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1902969"(mitotic DNA replication)|ensembl:ENSG00000076003(gene)|reactome:R-HSA-68962|reactome:R-HSA-69052|interpro:IPR008049(MCM protein 6)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|interpro:IPR018525|interpro:IPR027417|interpro:IPR027925|interpro:IPR031327|interpro:IPR033762|interpro:IPR041024|interpro:IPR041562|interpro:IPR001208(MCM)|mint:Q14566|rcsb pdb:2KLQ|rcsb pdb:2LE8|rcsb pdb:6XTX|rcsb pdb:6XTY|reactome:R-HSA-176187|reactome:R-HSA-176974|reactome:R-HSA-68867|reactome:R-HSA-68949|refseq:NP_005906.2|dip:DIP-31727N	-	-	-	figure legend:f5|comment:"To understand the interaction of MCM2-7 with MCM-BP at protein level,  following experiment was carried out. Flag-tagged MCM-BP was co-expressed with  MCM2-7 proteins in insect cells. Flag-tagged MCM-BP was purified using  anti-Flag-agarose beads, and co-purified MCM2-7 proteins were analyzed (Fig. 5).  Purified protein complex containing Flag-MCM-BP was separated by glycerol gradient  centrifugation. As reported earlier (20), co-recovery of MCM3-7 was observed.  Western-blot analysis where purified MCM2-7 proteins were co-electrophoresed shows  that MCM3, MCM5 and MCM7 were mainly recovered with MCM-BP and smaller  amounts of MCM4 and MCM6 were also recovered, suggesting that MCM-BP has  higher affinity for MCM3, MCM5 and MCM7. Position of sedimentation suggests that  MCM-BP mainly form dimmers by interacting with MCM3, MCM5 or MCM7. Thus  these all results suggest that MCM-BP disassembles MCM2-7 complex on the DNA by  interacting with MCM3, MCM5 and MCM7 proteins."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:7111(trini-high_5)|taxid:7111(Trichoplusia ni cell line from eggs)	-	2013/11/27	2014/10/16	rogid:8mXHWwvrQneZZArPvAEj1JZwOrg9606	rogid:gVpEwgfSwwxvP2T2CvCzIukthY49606	intact-crc:FD1C1320117C344B|rigid:Znn+ePjMWtKL734hQKWEM6KhYYU	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9BTE3	uniprotkb:P33992	intact:EBI-749378|uniprotkb:Q6IA56|uniprotkb:Q9BVT9|uniprotkb:Q9H916|uniprotkb:B3KSP7|ensembl:ENSP00000353098	intact:EBI-359410|ensembl:ENSP00000216122|uniprotkb:O60785|uniprotkb:Q14578|uniprotkb:Q9BTJ4|uniprotkb:Q9BWL8	psi-mi:mcmbp_human(display_long)|uniprotkb:MCMBP(gene name)|psi-mi:MCMBP(display_short)|uniprotkb:C10orf119(gene name synonym)	psi-mi:mcm5_human(display_long)|uniprotkb:MCM5(gene name)|psi-mi:MCM5(display_short)|uniprotkb:CDC46(gene name synonym)|uniprotkb:CDC46 homolog(gene name synonym)|uniprotkb:P1-CDC46(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Kusunoki et al. (2013)	pubmed:24299456|imex:IM-22017	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8875990|imex:IM-22017-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_079110.1|refseq:NP_001243307.1|refseq:NP_001243308.1|ensembl:ENSG00000197771(gene)|ensembl:ENST00000360003(transcript)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006261"(DNA-dependent DNA replication)|go:"GO:0007062"(sister chromatid cohesion)|go:"GO:0030054"(cell junction)|go:"GO:0051301"(cell division)|interpro:IPR019140|rcsb pdb:4KG9	ensembl:ENSG00000100297(gene)|ensembl:ENST00000216122(transcript)|go:"GO:0000727"(double-strand break repair via break-induced replication)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006260"(DNA replication)|go:"GO:0006267"(pre-replicative complex assembly involved in nuclear cell cycle DNA replication)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0016020"(membrane)|go:"GO:0042555"(MCM complex)|go:"GO:0071162"(CMG complex)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR001208(MCM)|interpro:IPR008048(MCM protein 5)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|interpro:IPR018525|interpro:IPR027417|interpro:IPR027925|interpro:IPR031327|interpro:IPR033762|interpro:IPR041562|mint:P33992|rcsb pdb:6XTX|rcsb pdb:6XTY|reactome:R-HSA-176187|reactome:R-HSA-176974|reactome:R-HSA-68867|reactome:R-HSA-68949|refseq:NP_006730.2|reactome:R-HSA-69052|reactome:R-HSA-68962|dip:DIP-27578N	-	-	-	figure legend:f5|comment:"To understand the interaction of MCM2-7 with MCM-BP at protein level,  following experiment was carried out. Flag-tagged MCM-BP was co-expressed with  MCM2-7 proteins in insect cells. Flag-tagged MCM-BP was purified using  anti-Flag-agarose beads, and co-purified MCM2-7 proteins were analyzed (Fig. 5).  Purified protein complex containing Flag-MCM-BP was separated by glycerol gradient  centrifugation. As reported earlier (20), co-recovery of MCM3-7 was observed.  Western-blot analysis where purified MCM2-7 proteins were co-electrophoresed shows  that MCM3, MCM5 and MCM7 were mainly recovered with MCM-BP and smaller  amounts of MCM4 and MCM6 were also recovered, suggesting that MCM-BP has  higher affinity for MCM3, MCM5 and MCM7. Position of sedimentation suggests that  MCM-BP mainly form dimmers by interacting with MCM3, MCM5 or MCM7. Thus  these all results suggest that MCM-BP disassembles MCM2-7 complex on the DNA by  interacting with MCM3, MCM5 and MCM7 proteins."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:7111(trini-high_5)|taxid:7111(Trichoplusia ni cell line from eggs)	-	2013/11/27	2014/10/16	rogid:8mXHWwvrQneZZArPvAEj1JZwOrg9606	rogid:WjJ4lSpADQFtwT0WnumbRHl/lPw9606	intact-crc:FD1C1320117C344B|rigid:Znn+ePjMWtKL734hQKWEM6KhYYU	false	flag tag:?-?	his tag:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9BTE3	uniprotkb:P25205	intact:EBI-749378|uniprotkb:Q6IA56|uniprotkb:Q9BVT9|uniprotkb:Q9H916|uniprotkb:B3KSP7|ensembl:ENSP00000353098	intact:EBI-355153|uniprotkb:B4DWW4|uniprotkb:Q92660|uniprotkb:Q9BTR3|uniprotkb:Q9NUE7|ensembl:ENSP00000472940	psi-mi:mcmbp_human(display_long)|uniprotkb:MCMBP(gene name)|psi-mi:MCMBP(display_short)|uniprotkb:C10orf119(gene name synonym)	psi-mi:mcm3_human(display_long)|uniprotkb:MCM3(gene name)|psi-mi:MCM3(display_short)|uniprotkb:DNA polymerase alpha holoenzyme-associated protein P1(gene name synonym)|uniprotkb:RLF subunit beta(gene name synonym)|uniprotkb:p102(gene name synonym)|uniprotkb:P1-MCM3(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Kusunoki et al. (2013)	pubmed:24299456|imex:IM-22017	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8875990|imex:IM-22017-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_079110.1|refseq:NP_001243307.1|refseq:NP_001243308.1|ensembl:ENSG00000197771(gene)|ensembl:ENST00000360003(transcript)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006261"(DNA-dependent DNA replication)|go:"GO:0007062"(sister chromatid cohesion)|go:"GO:0030054"(cell junction)|go:"GO:0051301"(cell division)|interpro:IPR019140|rcsb pdb:4KG9	refseq:NP_002379.3|refseq:NP_001257401.1|ensembl:ENSG00000112118(gene)|ensembl:ENST00000596288(transcript)|go:"GO:0000727"(double-strand break repair via break-induced replication)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003677"(DNA binding)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005658"("alpha DNA polymerase:primase complex")|go:"GO:0005813"(centrosome)|go:"GO:0006267"(pre-replicative complex assembly involved in nuclear cell cycle DNA replication)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0006271"(DNA strand elongation involved in DNA replication)|go:"GO:0016020"(membrane)|go:"GO:0042555"(MCM complex)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0071162"(CMG complex)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1902975"(mitotic DNA replication initiation)|interpro:IPR001208(MCM)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR008046(MCM protein 3)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|interpro:IPR018525|interpro:IPR027417|interpro:IPR027925|interpro:IPR031327|interpro:IPR033762|interpro:IPR041562|mint:P25205|rcsb pdb:6XTX|rcsb pdb:6XTY|reactome:R-HSA-176187|reactome:R-HSA-176974|reactome:R-HSA-68867|reactome:R-HSA-68949|reactome:R-HSA-68962|reactome:R-HSA-69052|dip:DIP-31726N	-	-	-	figure legend:f5|comment:"To understand the interaction of MCM2-7 with MCM-BP at protein level,  following experiment was carried out. Flag-tagged MCM-BP was co-expressed with  MCM2-7 proteins in insect cells. Flag-tagged MCM-BP was purified using  anti-Flag-agarose beads, and co-purified MCM2-7 proteins were analyzed (Fig. 5).  Purified protein complex containing Flag-MCM-BP was separated by glycerol gradient  centrifugation. As reported earlier (20), co-recovery of MCM3-7 was observed.  Western-blot analysis where purified MCM2-7 proteins were co-electrophoresed shows  that MCM3, MCM5 and MCM7 were mainly recovered with MCM-BP and smaller  amounts of MCM4 and MCM6 were also recovered, suggesting that MCM-BP has  higher affinity for MCM3, MCM5 and MCM7. Position of sedimentation suggests that  MCM-BP mainly form dimmers by interacting with MCM3, MCM5 or MCM7. Thus  these all results suggest that MCM-BP disassembles MCM2-7 complex on the DNA by  interacting with MCM3, MCM5 and MCM7 proteins."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:7111(trini-high_5)|taxid:7111(Trichoplusia ni cell line from eggs)	-	2013/11/27	2014/10/16	rogid:8mXHWwvrQneZZArPvAEj1JZwOrg9606	rogid:pKYSPG/QbSyVVJtZamU5lVjgIGo9606	intact-crc:FD1C1320117C344B|rigid:Znn+ePjMWtKL734hQKWEM6KhYYU	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9BTE3	uniprotkb:P33991	intact:EBI-749378|uniprotkb:Q6IA56|uniprotkb:Q9BVT9|uniprotkb:Q9H916|uniprotkb:B3KSP7|ensembl:ENSP00000353098	intact:EBI-374938|uniprotkb:Q8NEH1|uniprotkb:Q99658|ensembl:ENSP00000262105|ensembl:ENSP00000496964	psi-mi:mcmbp_human(display_long)|uniprotkb:MCMBP(gene name)|psi-mi:MCMBP(display_short)|uniprotkb:C10orf119(gene name synonym)	psi-mi:mcm4_human(display_long)|uniprotkb:MCM4(gene name)|psi-mi:MCM4(display_short)|uniprotkb:CDC21(gene name synonym)|uniprotkb:CDC21 homolog(gene name synonym)|uniprotkb:P1-CDC21(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Kusunoki et al. (2013)	pubmed:24299456|imex:IM-22017	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8875990|imex:IM-22017-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_079110.1|refseq:NP_001243307.1|refseq:NP_001243308.1|ensembl:ENSG00000197771(gene)|ensembl:ENST00000360003(transcript)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006261"(DNA-dependent DNA replication)|go:"GO:0007062"(sister chromatid cohesion)|go:"GO:0030054"(cell junction)|go:"GO:0051301"(cell division)|interpro:IPR019140|rcsb pdb:4KG9	refseq:NP_005905.2|refseq:NP_877423.1|ensembl:ENSG00000104738(gene)|ensembl:ENST00000262105(transcript)|ensembl:ENST00000649973(transcript)|go:"GO:0000727"(double-strand break repair via break-induced replication)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006260"(DNA replication)|go:"GO:0006267"(pre-replicative complex assembly involved in nuclear cell cycle DNA replication)|go:"GO:0006268"(DNA unwinding involved in DNA replication)|go:"GO:0006271"(DNA strand elongation involved in DNA replication)|go:"GO:0016020"(membrane)|go:"GO:0042555"(MCM complex)|go:"GO:0071162"(CMG complex)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1902975"(mitotic DNA replication initiation)|interpro:IPR001208(MCM)|interpro:IPR008047(MCM protein 4)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|interpro:IPR018525|interpro:IPR027417|interpro:IPR027925|interpro:IPR031327|interpro:IPR033762|interpro:IPR041562|mint:P33991|rcsb pdb:6XTX|rcsb pdb:6XTY|reactome:R-HSA-176187|reactome:R-HSA-176974|reactome:R-HSA-68867|reactome:R-HSA-68949|reactome:R-HSA-68962|reactome:R-HSA-69052|dip:DIP-31729N	-	-	-	figure legend:f5|comment:"To understand the interaction of MCM2-7 with MCM-BP at protein level,  following experiment was carried out. Flag-tagged MCM-BP was co-expressed with  MCM2-7 proteins in insect cells. Flag-tagged MCM-BP was purified using  anti-Flag-agarose beads, and co-purified MCM2-7 proteins were analyzed (Fig. 5).  Purified protein complex containing Flag-MCM-BP was separated by glycerol gradient  centrifugation. As reported earlier (20), co-recovery of MCM3-7 was observed.  Western-blot analysis where purified MCM2-7 proteins were co-electrophoresed shows  that MCM3, MCM5 and MCM7 were mainly recovered with MCM-BP and smaller  amounts of MCM4 and MCM6 were also recovered, suggesting that MCM-BP has  higher affinity for MCM3, MCM5 and MCM7. Position of sedimentation suggests that  MCM-BP mainly form dimmers by interacting with MCM3, MCM5 or MCM7. Thus  these all results suggest that MCM-BP disassembles MCM2-7 complex on the DNA by  interacting with MCM3, MCM5 and MCM7 proteins."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:7111(trini-high_5)|taxid:7111(Trichoplusia ni cell line from eggs)	-	2013/11/27	2014/10/16	rogid:8mXHWwvrQneZZArPvAEj1JZwOrg9606	rogid:emFkamsHmwBPzoJnPcaL4SaqAlU9606	intact-crc:FD1C1320117C344B|rigid:Znn+ePjMWtKL734hQKWEM6KhYYU	false	flag tag:?-?	his tag:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9BTE3	uniprotkb:P33993	intact:EBI-749378|uniprotkb:Q6IA56|uniprotkb:Q9BVT9|uniprotkb:Q9H916|uniprotkb:B3KSP7|ensembl:ENSP00000353098	intact:EBI-355924|uniprotkb:Q15076|uniprotkb:Q96D34|uniprotkb:Q96GL1|uniprotkb:A4D2A1|uniprotkb:A4D2A2|uniprotkb:E9PGN9|ensembl:ENSP00000307288	psi-mi:mcmbp_human(display_long)|uniprotkb:MCMBP(gene name)|psi-mi:MCMBP(display_short)|uniprotkb:C10orf119(gene name synonym)	psi-mi:mcm7_human(display_long)|uniprotkb:MCM7(gene name)|psi-mi:MCM7(display_short)|uniprotkb:CDC47(gene name synonym)|uniprotkb:MCM2(gene name synonym)|uniprotkb:CDC47 homolog(gene name synonym)|uniprotkb:P1.1-MCM3(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Kusunoki et al. (2013)	pubmed:24299456|imex:IM-22017	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8875990|imex:IM-22017-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_079110.1|refseq:NP_001243307.1|refseq:NP_001243308.1|ensembl:ENSG00000197771(gene)|ensembl:ENST00000360003(transcript)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006261"(DNA-dependent DNA replication)|go:"GO:0007062"(sister chromatid cohesion)|go:"GO:0030054"(cell junction)|go:"GO:0051301"(cell division)|interpro:IPR019140|rcsb pdb:4KG9	refseq:NP_001265524.1|refseq:NP_005907.3|refseq:NP_877577.1|ensembl:ENSG00000166508(gene)|ensembl:ENST00000303887(transcript)|go:"GO:0000727"(double-strand break repair via break-induced replication)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000785"(chromatin)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0016020"(membrane)|go:"GO:0042325"(regulation of phosphorylation)|go:"GO:0042493"|go:"GO:0042555"(MCM complex)|go:"GO:0071162"(CMG complex)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0071466"(cellular response to xenobiotic stimulus)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR001208(MCM)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006260"(DNA replication)|go:"GO:0006267"(pre-replicative complex assembly involved in nuclear cell cycle DNA replication)|go:"GO:0006268"(DNA unwinding involved in DNA replication)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0006271"(DNA strand elongation involved in DNA replication)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008283"(cell population proliferation)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR008050(MCM protein 7)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|interpro:IPR018525|interpro:IPR027417|interpro:IPR027925|interpro:IPR031327|interpro:IPR033762|interpro:IPR041562|mint:P33993|rcsb pdb:6XTX|rcsb pdb:6XTY|reactome:R-HSA-176187|reactome:R-HSA-176974|reactome:R-HSA-68867|reactome:R-HSA-68949|reactome:R-HSA-68962|reactome:R-HSA-69052|dip:DIP-27580N	-	-	-	figure legend:f5|comment:"To understand the interaction of MCM2-7 with MCM-BP at protein level,  following experiment was carried out. Flag-tagged MCM-BP was co-expressed with  MCM2-7 proteins in insect cells. Flag-tagged MCM-BP was purified using  anti-Flag-agarose beads, and co-purified MCM2-7 proteins were analyzed (Fig. 5).  Purified protein complex containing Flag-MCM-BP was separated by glycerol gradient  centrifugation. As reported earlier (20), co-recovery of MCM3-7 was observed.  Western-blot analysis where purified MCM2-7 proteins were co-electrophoresed shows  that MCM3, MCM5 and MCM7 were mainly recovered with MCM-BP and smaller  amounts of MCM4 and MCM6 were also recovered, suggesting that MCM-BP has  higher affinity for MCM3, MCM5 and MCM7. Position of sedimentation suggests that  MCM-BP mainly form dimmers by interacting with MCM3, MCM5 or MCM7. Thus  these all results suggest that MCM-BP disassembles MCM2-7 complex on the DNA by  interacting with MCM3, MCM5 and MCM7 proteins."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:7111(trini-high_5)|taxid:7111(Trichoplusia ni cell line from eggs)	-	2013/11/27	2014/10/16	rogid:8mXHWwvrQneZZArPvAEj1JZwOrg9606	rogid:hrpCntkzdVgewNA+/iPS6b50dGY9606	intact-crc:FD1C1320117C344B|rigid:Znn+ePjMWtKL734hQKWEM6KhYYU	false	flag tag:?-?	his tag:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)