#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P33225	uniprotkb:P0A9M0	intact:EBI-557008|uniprotkb:P78227|ensemblbacteria:AAC74082|ensemblbacteria:BAA36139	intact:EBI-547203|uniprotkb:P08177|uniprotkb:Q2MBY7|uniprotkb:P78219|ensemblbacteria:AAC73542|ensemblbacteria:BAE76219	psi-mi:tora_ecoli(display_long)|uniprotkb:torA(gene name)|psi-mi:torA(display_short)|uniprotkb:b0997(locus name)|uniprotkb:JW0982(locus name)	psi-mi:lon_ecoli(display_long)|uniprotkb:lon(gene name)|psi-mi:lon(display_short)|uniprotkb:capR(gene name synonym)|uniprotkb:deg(gene name synonym)|uniprotkb:lopA(gene name synonym)|uniprotkb:muc(gene name synonym)|uniprotkb:b0439(locus name)|uniprotkb:ATP-dependent protease La(gene name synonym)|uniprotkb:JW0429(locus name)	psi-mi:"MI:0107"(surface plasmon resonance)	David et al. (2013)	pubmed:24211448|imex:IM-21713	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-8838464|imex:IM-21713-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_415517.1|refseq:WP_001062091.1|dip:DIP-11013N|mint:P33225|go:"GO:0009061"(anaerobic respiration)|ensemblbacteria:AAC74082(transcript)|go:"GO:0030151"(molybdenum ion binding)|go:"GO:0030288"(outer membrane-bounded periplasmic space)|go:"GO:0043546"(molybdopterin cofactor binding)|go:"GO:0050626"("trimethylamine-N-oxide reductase (cytochrome c) activity")|go:"GO:0019645"(anaerobic electron transport chain)|interpro:IPR006311(Twin-arginine translocation pathway signal)|interpro:IPR006655(Molybdopterin oxidoreductase, prokaryotic, conserved site)|ensemblbacteria:b0997(gene)|ensemblbacteria:BAA36139(gene)|ensemblbacteria:BAA36139(transcript)|go:"GO:0009055"(electron transfer activity)|go:"GO:0009060"(aerobic respiration)|interpro:IPR006657(Molydopterin dinucleotide-binding region)|interpro:IPR006658(Molybdopterin guanine dinucleotide-containing S/N-oxide reductase)|interpro:IPR009010(Aspartate decarboxylase-like fold)|interpro:IPR011887(Trimethylamine-N-oxide reductase TorA)|interpro:IPR041460|interpro:IPR041954|interpro:IPR006656(Molybdopterin oxidoreductase)	refseq:NP_414973.1|refseq:WP_001295325.1|ensemblbacteria:AAC73542(transcript)|ensemblbacteria:b0439(gene)|ensemblbacteria:BAE76219(gene)|ensemblbacteria:BAE76219(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0004176"(ATP-dependent peptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006508"(proteolysis)|go:"GO:0006515"(protein quality control for misfolded or incompletely synthesized proteins)|go:"GO:0008233"(peptidase activity)|go:"GO:0009408"(response to heat)|go:"GO:0010165"(response to X-ray)|go:"GO:0034605"(cellular response to heat)|go:"GO:0043565"(sequence-specific DNA binding)|interpro:IPR003111(Peptidase S16, lon N-terminal)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR004815(Peptidase S16, ATP-dependent protease La)|interpro:IPR008268(Peptidase S16, active site)|interpro:IPR008269(Peptidase S16, lon C-terminal)|interpro:IPR014721(Ribosomal protein S5 domain 2-type fold)|interpro:IPR015947(PUA-like)|interpro:IPR020568|interpro:IPR027065|interpro:IPR027417|interpro:IPR027543|rcsb pdb:1QZM|rcsb pdb:1RR9|rcsb pdb:1RRE|rcsb pdb:2ANE|rcsb pdb:3LJC|rcsb pdb:6N2I|rcsb pdb:6U5Z|mint:P0A9M0|dip:DIP-35845N	-	-	-	figure legend:f2|comment:"The first set of results suggests that Lon recognizes only the core of apoTorA. To confirm this point, a  surface plasmon resonance (SPR) experiment was carried out to follow, in real time, the interaction  between Lon and the apo or holo form of TorA. The data show an interaction between Lon and  apoTorA (Fig. 2),. Moreover, this data set shows the formation of a very stable complex between Lon  and apoTorA. The determination of the equilibrium constant level (Req) at different concentrations  allows us to estimate after three independent experiments a Kd of 1.0 ± 0.2 μM. In contrast, no  interaction was detected with holoTorA (Fig.2 inset) confirming that the protease binds the core of  TorA only in the absence of the cofactor."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:1.0x10^-6(molar)	2013/10/30	2014/10/16	rogid:zhHOF4D1KWgeoRZXP85Q6T8BBGI83333	rogid:p0W6XDC/CVzvsPmFzp0zYrTpr7083333	intact-crc:4F342A8AD911826B|rigid:RHOEq4tnA54tg8uCgRBrPBvP+tU	false	his tag:?-?	his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P33225	uniprotkb:P0A9M0	intact:EBI-557008|uniprotkb:P78227|ensemblbacteria:AAC74082|ensemblbacteria:BAA36139	intact:EBI-547203|uniprotkb:P08177|uniprotkb:Q2MBY7|uniprotkb:P78219|ensemblbacteria:AAC73542|ensemblbacteria:BAE76219	psi-mi:tora_ecoli(display_long)|uniprotkb:torA(gene name)|psi-mi:torA(display_short)|uniprotkb:b0997(locus name)|uniprotkb:JW0982(locus name)	psi-mi:lon_ecoli(display_long)|uniprotkb:lon(gene name)|psi-mi:lon(display_short)|uniprotkb:capR(gene name synonym)|uniprotkb:deg(gene name synonym)|uniprotkb:lopA(gene name synonym)|uniprotkb:muc(gene name synonym)|uniprotkb:b0439(locus name)|uniprotkb:ATP-dependent protease La(gene name synonym)|uniprotkb:JW0429(locus name)	psi-mi:"MI:0415"(enzymatic study)	David et al. (2013)	pubmed:24211448|imex:IM-21713	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	psi-mi:"MI:0194"(cleavage reaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-8838577|imex:IM-21713-2	-	-	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_415517.1|refseq:WP_001062091.1|dip:DIP-11013N|mint:P33225|go:"GO:0009061"(anaerobic respiration)|ensemblbacteria:AAC74082(transcript)|go:"GO:0030151"(molybdenum ion binding)|go:"GO:0030288"(outer membrane-bounded periplasmic space)|go:"GO:0043546"(molybdopterin cofactor binding)|go:"GO:0050626"("trimethylamine-N-oxide reductase (cytochrome c) activity")|go:"GO:0019645"(anaerobic electron transport chain)|interpro:IPR006311(Twin-arginine translocation pathway signal)|interpro:IPR006655(Molybdopterin oxidoreductase, prokaryotic, conserved site)|ensemblbacteria:b0997(gene)|ensemblbacteria:BAA36139(gene)|ensemblbacteria:BAA36139(transcript)|go:"GO:0009055"(electron transfer activity)|go:"GO:0009060"(aerobic respiration)|interpro:IPR006657(Molydopterin dinucleotide-binding region)|interpro:IPR006658(Molybdopterin guanine dinucleotide-containing S/N-oxide reductase)|interpro:IPR009010(Aspartate decarboxylase-like fold)|interpro:IPR011887(Trimethylamine-N-oxide reductase TorA)|interpro:IPR041460|interpro:IPR041954|interpro:IPR006656(Molybdopterin oxidoreductase)	refseq:NP_414973.1|refseq:WP_001295325.1|ensemblbacteria:AAC73542(transcript)|ensemblbacteria:b0439(gene)|ensemblbacteria:BAE76219(gene)|ensemblbacteria:BAE76219(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0004176"(ATP-dependent peptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006508"(proteolysis)|go:"GO:0006515"(protein quality control for misfolded or incompletely synthesized proteins)|go:"GO:0008233"(peptidase activity)|go:"GO:0009408"(response to heat)|go:"GO:0010165"(response to X-ray)|go:"GO:0034605"(cellular response to heat)|go:"GO:0043565"(sequence-specific DNA binding)|interpro:IPR003111(Peptidase S16, lon N-terminal)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR004815(Peptidase S16, ATP-dependent protease La)|interpro:IPR008268(Peptidase S16, active site)|interpro:IPR008269(Peptidase S16, lon C-terminal)|interpro:IPR014721(Ribosomal protein S5 domain 2-type fold)|interpro:IPR015947(PUA-like)|interpro:IPR020568|interpro:IPR027065|interpro:IPR027417|interpro:IPR027543|rcsb pdb:1QZM|rcsb pdb:1RR9|rcsb pdb:1RRE|rcsb pdb:2ANE|rcsb pdb:3LJC|rcsb pdb:6N2I|rcsb pdb:6U5Z|mint:P0A9M0|dip:DIP-35845N	-	-	-	figure legend:f4a f4c|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/10/30	2014/10/16	rogid:zhHOF4D1KWgeoRZXP85Q6T8BBGI83333	rogid:p0W6XDC/CVzvsPmFzp0zYrTpr7083333	intact-crc:9CB9639752BD2D9E|rigid:RHOEq4tnA54tg8uCgRBrPBvP+tU	false	his tag:?-?	his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)