#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:A1Z6I7	uniprotkb:Q9VRQ2	intact:EBI-155060|ensemblmetazoa:FBpp0085368	intact:EBI-169350|ensemblmetazoa:FBpp0076819	psi-mi:a1z6i7_drome(display_long)|uniprotkb:BubR1(gene name)|psi-mi:BubR1(display_short)|uniprotkb:Bub1(gene name synonym)|uniprotkb:13(gene name synonym)|uniprotkb:31(gene name synonym)|uniprotkb:BUB1(gene name synonym)|uniprotkb:BUBR1(gene name synonym)|uniprotkb:"BcDNA:LD23835"(gene name synonym)|uniprotkb:CG 7838(gene name synonym)|uniprotkb:DmBUB1(gene name synonym)|uniprotkb:DmBubRI(gene name synonym)|uniprotkb:Dmbub1(gene name synonym)|uniprotkb:Dmel\CG7838(gene name synonym)|uniprotkb:bub1(gene name synonym)|uniprotkb:bubR1(gene name synonym)|uniprotkb:bubr1(gene name synonym)|uniprotkb:dBUB1(gene name synonym)|uniprotkb:"l(2)k03113"(gene name synonym)|uniprotkb:"l(2)k06109"(gene name synonym)|uniprotkb:"mcl(2)Z1525"(gene name synonym)|uniprotkb:CG7838(orf name)|uniprotkb:Dmel_CG7838(orf name)	psi-mi:q9vrq2_drome(display_long)|uniprotkb:mad2(gene name)|psi-mi:mad2(display_short)|uniprotkb:Dmel\CG17498(gene name synonym)|uniprotkb:MAD2(gene name synonym)|uniprotkb:Mad2(gene name synonym)|uniprotkb:Dmel_CG17498(orf name)|uniprotkb:CG17498(orf name)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Conde et al. (2013)	pubmed:23685359|imex:IM-21579	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8795568|imex:IM-21579-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_477382.1|ensemblmetazoa:FBgn0263855(gene)|ensemblmetazoa:FBtr0086032(transcript)|go:"GO:0000776"(kinetochore)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0007065"(male meiosis sister chromatid cohesion)|go:"GO:0007066"(female meiosis sister chromatid cohesion)|go:"GO:0007094"(mitotic spindle assembly checkpoint signaling)|go:"GO:0007096"(regulation of exit from mitosis)|go:"GO:0010965"(regulation of mitotic sister chromatid separation)|go:"GO:0031937"(obsolete positive regulation of chromatin silencing)|go:"GO:0051754"(meiotic sister chromatid cohesion, centromeric)|go:"GO:0070193"(synaptonemal complex organization)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013212(Mad3/BUB1 homology region 1)|interpro:IPR015661(Mitotic checkpoint serine/threonine protein kinase, Bub1)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:A1Z6I7|rcsb pdb:6JKK|rcsb pdb:6JKM|reactome:R-DME-141430|reactome:R-DME-174184|reactome:R-DME-176409|reactome:R-DME-179409|flybase:FBgn0263855	ensemblmetazoa:FBgn0035640(gene)|ensemblmetazoa:FBtr0077113(transcript)|go:"GO:0000776"(kinetochore)|go:"GO:0000922"(spindle pole)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005819"(spindle)|go:"GO:0005828"(kinetochore microtubule)|go:"GO:0007094"(mitotic spindle assembly checkpoint signaling)|go:"GO:0007346"(regulation of mitotic cell cycle)|go:"GO:0048133"(male germ-line stem cell asymmetric division)|go:"GO:0072686"(mitotic spindle)|go:"GO:0090266"(regulation of mitotic cell cycle spindle assembly checkpoint)|go:"GO:1901673"(regulation of mitotic spindle assembly)|go:"GO:1990047"(spindle matrix)|interpro:IPR003511(DNA-binding HORMA)|interpro:IPR027097|interpro:IPR036570|mint:Q9VRQ2|reactome:R-DME-141405|reactome:R-DME-141430|reactome:R-DME-174184|reactome:R-DME-176409|reactome:R-DME-179409|go:"GO:0051276"(chromosome organization)|refseq:NP_647991.1|flybase:FBgn0035640	-	-	-	figure legend:f6c|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:7227(drome-schneider_2)|taxid:7227(Drosophila melanogaster late embryo cells)	-	2013/10/16	2014/10/16	rogid:oYFJqxeFO6p6FB/pk1ZKfRONMTw7227	rogid:D0FlcrqNeN8Kp5KUYPNfiRhVUSg7227	intact-crc:D950F535B7EAA8F2|rigid:B/cD2u7zYkaYfbA3/5YLlCS+R5g	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:A1Z6I7	uniprotkb:Q24044	intact:EBI-155060|ensemblmetazoa:FBpp0085368	intact:EBI-176696|ensemblmetazoa:FBpp0080391	psi-mi:a1z6i7_drome(display_long)|uniprotkb:BubR1(gene name)|psi-mi:BubR1(display_short)|uniprotkb:Bub1(gene name synonym)|uniprotkb:13(gene name synonym)|uniprotkb:31(gene name synonym)|uniprotkb:BUB1(gene name synonym)|uniprotkb:BUBR1(gene name synonym)|uniprotkb:"BcDNA:LD23835"(gene name synonym)|uniprotkb:CG 7838(gene name synonym)|uniprotkb:DmBUB1(gene name synonym)|uniprotkb:DmBubRI(gene name synonym)|uniprotkb:Dmbub1(gene name synonym)|uniprotkb:Dmel\CG7838(gene name synonym)|uniprotkb:bub1(gene name synonym)|uniprotkb:bubR1(gene name synonym)|uniprotkb:bubr1(gene name synonym)|uniprotkb:dBUB1(gene name synonym)|uniprotkb:"l(2)k03113"(gene name synonym)|uniprotkb:"l(2)k06109"(gene name synonym)|uniprotkb:"mcl(2)Z1525"(gene name synonym)|uniprotkb:CG7838(orf name)|uniprotkb:Dmel_CG7838(orf name)	psi-mi:q24044_drome(display_long)|uniprotkb:fzy-RA(gene name synonym)|uniprotkb:fzy(gene name)|psi-mi:fzy(display_short)|uniprotkb:Dmel_CG4274(orf name)|uniprotkb:"BG:DS02740.14"(gene name synonym)|uniprotkb:CDC20(gene name synonym)|uniprotkb:Cdc20(gene name synonym)|uniprotkb:Cdc20[Fzy](gene name synonym)|uniprotkb:Cdc20[fizzy](gene name synonym)|uniprotkb:Dmel\CG4274(gene name synonym)|uniprotkb:FZY(gene name synonym)|uniprotkb:Fizzy(gene name synonym)|uniprotkb:Fzy(gene name synonym)|uniprotkb:cdc20(gene name synonym)|uniprotkb:dCDC20(gene name synonym)|uniprotkb:dFZY(gene name synonym)|uniprotkb:fizzy(gene name synonym)|uniprotkb:CG4274(orf name)|uniprotkb:Cdc20FZY(gene name synonym)|uniprotkb:cdc2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Conde et al. (2013)	pubmed:23685359|imex:IM-21579	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8795568|imex:IM-21579-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_477382.1|ensemblmetazoa:FBgn0263855(gene)|ensemblmetazoa:FBtr0086032(transcript)|go:"GO:0000776"(kinetochore)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0007065"(male meiosis sister chromatid cohesion)|go:"GO:0007066"(female meiosis sister chromatid cohesion)|go:"GO:0007094"(mitotic spindle assembly checkpoint signaling)|go:"GO:0007096"(regulation of exit from mitosis)|go:"GO:0010965"(regulation of mitotic sister chromatid separation)|go:"GO:0031937"(obsolete positive regulation of chromatin silencing)|go:"GO:0051754"(meiotic sister chromatid cohesion, centromeric)|go:"GO:0070193"(synaptonemal complex organization)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013212(Mad3/BUB1 homology region 1)|interpro:IPR015661(Mitotic checkpoint serine/threonine protein kinase, Bub1)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:A1Z6I7|rcsb pdb:6JKK|rcsb pdb:6JKM|reactome:R-DME-141430|reactome:R-DME-174184|reactome:R-DME-176409|reactome:R-DME-179409|flybase:FBgn0263855	refseq:NP_477501.1|flybase:FBgn0001086|dip:DIP-60667N|ensemblmetazoa:FBgn0001086(gene)|ensemblmetazoa:FBtr0080833(transcript)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000776"(kinetochore)|go:"GO:0005680"(anaphase-promoting complex)|go:"GO:0005813"(centrosome)|go:"GO:0005819"(spindle)|go:"GO:0007144"(female meiosis I)|go:"GO:0007147"(female meiosis II)|go:"GO:0010997"(anaphase-promoting complex binding)|go:"GO:0030163"(protein catabolic process)|go:"GO:0030718"(germ-line stem cell population maintenance)|go:"GO:0031145"(anaphase-promoting complex-dependent catabolic process)|go:"GO:0060547"(negative regulation of necrotic cell death)|go:"GO:0097150"(neuronal stem cell population maintenance)|go:"GO:1904668"(positive regulation of ubiquitin protein ligase activity)|go:"GO:1905786"(positive regulation of anaphase-promoting complex-dependent catabolic process)|go:"GO:1990757"(ubiquitin ligase activator activity)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR024977|interpro:IPR033010|interpro:IPR036322|mint:Q24044|reactome:R-DME-141405|reactome:R-DME-141430|reactome:R-DME-174048|reactome:R-DME-174154|reactome:R-DME-174178|reactome:R-DME-174184|reactome:R-DME-176407|reactome:R-DME-176408|reactome:R-DME-176409|reactome:R-DME-176417|reactome:R-DME-179409|reactome:R-DME-2467813|reactome:R-DME-983168	-	-	-	figure legend:f6c|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:7227(drome-schneider_2)|taxid:7227(Drosophila melanogaster late embryo cells)	-	2013/10/16	2014/10/16	rogid:oYFJqxeFO6p6FB/pk1ZKfRONMTw7227	rogid:o3IV0N/UEpFvqMOFNx4/bxLUUV87227	intact-crc:D950F535B7EAA8F2|rigid:B/cD2u7zYkaYfbA3/5YLlCS+R5g	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q24044	uniprotkb:Q9VRQ2	intact:EBI-176696|ensemblmetazoa:FBpp0080391	intact:EBI-169350|ensemblmetazoa:FBpp0076819	psi-mi:q24044_drome(display_long)|uniprotkb:fzy-RA(gene name synonym)|uniprotkb:fzy(gene name)|psi-mi:fzy(display_short)|uniprotkb:Dmel_CG4274(orf name)|uniprotkb:"BG:DS02740.14"(gene name synonym)|uniprotkb:CDC20(gene name synonym)|uniprotkb:Cdc20(gene name synonym)|uniprotkb:Cdc20[Fzy](gene name synonym)|uniprotkb:Cdc20[fizzy](gene name synonym)|uniprotkb:Dmel\CG4274(gene name synonym)|uniprotkb:FZY(gene name synonym)|uniprotkb:Fizzy(gene name synonym)|uniprotkb:Fzy(gene name synonym)|uniprotkb:cdc20(gene name synonym)|uniprotkb:dCDC20(gene name synonym)|uniprotkb:dFZY(gene name synonym)|uniprotkb:fizzy(gene name synonym)|uniprotkb:CG4274(orf name)|uniprotkb:Cdc20FZY(gene name synonym)|uniprotkb:cdc2(gene name synonym)	psi-mi:q9vrq2_drome(display_long)|uniprotkb:mad2(gene name)|psi-mi:mad2(display_short)|uniprotkb:Dmel\CG17498(gene name synonym)|uniprotkb:MAD2(gene name synonym)|uniprotkb:Mad2(gene name synonym)|uniprotkb:Dmel_CG17498(orf name)|uniprotkb:CG17498(orf name)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Conde et al. (2013)	pubmed:23685359|imex:IM-21579	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8795574|imex:IM-21579-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_477501.1|flybase:FBgn0001086|dip:DIP-60667N|ensemblmetazoa:FBgn0001086(gene)|ensemblmetazoa:FBtr0080833(transcript)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000776"(kinetochore)|go:"GO:0005680"(anaphase-promoting complex)|go:"GO:0005813"(centrosome)|go:"GO:0005819"(spindle)|go:"GO:0007144"(female meiosis I)|go:"GO:0007147"(female meiosis II)|go:"GO:0010997"(anaphase-promoting complex binding)|go:"GO:0030163"(protein catabolic process)|go:"GO:0030718"(germ-line stem cell population maintenance)|go:"GO:0031145"(anaphase-promoting complex-dependent catabolic process)|go:"GO:0060547"(negative regulation of necrotic cell death)|go:"GO:0097150"(neuronal stem cell population maintenance)|go:"GO:1904668"(positive regulation of ubiquitin protein ligase activity)|go:"GO:1905786"(positive regulation of anaphase-promoting complex-dependent catabolic process)|go:"GO:1990757"(ubiquitin ligase activator activity)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR024977|interpro:IPR033010|interpro:IPR036322|mint:Q24044|reactome:R-DME-141405|reactome:R-DME-141430|reactome:R-DME-174048|reactome:R-DME-174154|reactome:R-DME-174178|reactome:R-DME-174184|reactome:R-DME-176407|reactome:R-DME-176408|reactome:R-DME-176409|reactome:R-DME-176417|reactome:R-DME-179409|reactome:R-DME-2467813|reactome:R-DME-983168	ensemblmetazoa:FBgn0035640(gene)|ensemblmetazoa:FBtr0077113(transcript)|go:"GO:0000776"(kinetochore)|go:"GO:0000922"(spindle pole)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005819"(spindle)|go:"GO:0005828"(kinetochore microtubule)|go:"GO:0007094"(mitotic spindle assembly checkpoint signaling)|go:"GO:0007346"(regulation of mitotic cell cycle)|go:"GO:0048133"(male germ-line stem cell asymmetric division)|go:"GO:0072686"(mitotic spindle)|go:"GO:0090266"(regulation of mitotic cell cycle spindle assembly checkpoint)|go:"GO:1901673"(regulation of mitotic spindle assembly)|go:"GO:1990047"(spindle matrix)|interpro:IPR003511(DNA-binding HORMA)|interpro:IPR027097|interpro:IPR036570|mint:Q9VRQ2|reactome:R-DME-141405|reactome:R-DME-141430|reactome:R-DME-174184|reactome:R-DME-176409|reactome:R-DME-179409|go:"GO:0051276"(chromosome organization)|refseq:NP_647991.1|flybase:FBgn0035640	-	-	-	figure legend:f6c f7c|comment:"cells  overexpressing Mps1 and treated with colchicine, co-immunoprecipitated  significantly higher levels of BubR1 with  Cdc20 than non-induced control cells (Figure 7C) further  supporting a model in which Mps1-regulated phosphorylation  of BubR1 is instrumental for the formation of the Cdc20-  BubR1 complex, which in turn is required for MCC assembly  and sustained SAC function."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:7227(drome-schneider_2)|taxid:7227(Drosophila melanogaster late embryo cells)	-	2013/10/16	2014/10/16	rogid:o3IV0N/UEpFvqMOFNx4/bxLUUV87227	rogid:D0FlcrqNeN8Kp5KUYPNfiRhVUSg7227	intact-crc:76CFCCDEDD9DB88C|rigid:B/cD2u7zYkaYfbA3/5YLlCS+R5g	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q24044	uniprotkb:A1Z6I7	intact:EBI-176696|ensemblmetazoa:FBpp0080391	intact:EBI-155060|ensemblmetazoa:FBpp0085368	psi-mi:q24044_drome(display_long)|uniprotkb:fzy-RA(gene name synonym)|uniprotkb:fzy(gene name)|psi-mi:fzy(display_short)|uniprotkb:Dmel_CG4274(orf name)|uniprotkb:"BG:DS02740.14"(gene name synonym)|uniprotkb:CDC20(gene name synonym)|uniprotkb:Cdc20(gene name synonym)|uniprotkb:Cdc20[Fzy](gene name synonym)|uniprotkb:Cdc20[fizzy](gene name synonym)|uniprotkb:Dmel\CG4274(gene name synonym)|uniprotkb:FZY(gene name synonym)|uniprotkb:Fizzy(gene name synonym)|uniprotkb:Fzy(gene name synonym)|uniprotkb:cdc20(gene name synonym)|uniprotkb:dCDC20(gene name synonym)|uniprotkb:dFZY(gene name synonym)|uniprotkb:fizzy(gene name synonym)|uniprotkb:CG4274(orf name)|uniprotkb:Cdc20FZY(gene name synonym)|uniprotkb:cdc2(gene name synonym)	psi-mi:a1z6i7_drome(display_long)|uniprotkb:BubR1(gene name)|psi-mi:BubR1(display_short)|uniprotkb:Bub1(gene name synonym)|uniprotkb:13(gene name synonym)|uniprotkb:31(gene name synonym)|uniprotkb:BUB1(gene name synonym)|uniprotkb:BUBR1(gene name synonym)|uniprotkb:"BcDNA:LD23835"(gene name synonym)|uniprotkb:CG 7838(gene name synonym)|uniprotkb:DmBUB1(gene name synonym)|uniprotkb:DmBubRI(gene name synonym)|uniprotkb:Dmbub1(gene name synonym)|uniprotkb:Dmel\CG7838(gene name synonym)|uniprotkb:bub1(gene name synonym)|uniprotkb:bubR1(gene name synonym)|uniprotkb:bubr1(gene name synonym)|uniprotkb:dBUB1(gene name synonym)|uniprotkb:"l(2)k03113"(gene name synonym)|uniprotkb:"l(2)k06109"(gene name synonym)|uniprotkb:"mcl(2)Z1525"(gene name synonym)|uniprotkb:CG7838(orf name)|uniprotkb:Dmel_CG7838(orf name)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Conde et al. (2013)	pubmed:23685359|imex:IM-21579	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8795574|imex:IM-21579-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_477501.1|flybase:FBgn0001086|dip:DIP-60667N|ensemblmetazoa:FBgn0001086(gene)|ensemblmetazoa:FBtr0080833(transcript)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000776"(kinetochore)|go:"GO:0005680"(anaphase-promoting complex)|go:"GO:0005813"(centrosome)|go:"GO:0005819"(spindle)|go:"GO:0007144"(female meiosis I)|go:"GO:0007147"(female meiosis II)|go:"GO:0010997"(anaphase-promoting complex binding)|go:"GO:0030163"(protein catabolic process)|go:"GO:0030718"(germ-line stem cell population maintenance)|go:"GO:0031145"(anaphase-promoting complex-dependent catabolic process)|go:"GO:0060547"(negative regulation of necrotic cell death)|go:"GO:0097150"(neuronal stem cell population maintenance)|go:"GO:1904668"(positive regulation of ubiquitin protein ligase activity)|go:"GO:1905786"(positive regulation of anaphase-promoting complex-dependent catabolic process)|go:"GO:1990757"(ubiquitin ligase activator activity)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR024977|interpro:IPR033010|interpro:IPR036322|mint:Q24044|reactome:R-DME-141405|reactome:R-DME-141430|reactome:R-DME-174048|reactome:R-DME-174154|reactome:R-DME-174178|reactome:R-DME-174184|reactome:R-DME-176407|reactome:R-DME-176408|reactome:R-DME-176409|reactome:R-DME-176417|reactome:R-DME-179409|reactome:R-DME-2467813|reactome:R-DME-983168	refseq:NP_477382.1|ensemblmetazoa:FBgn0263855(gene)|ensemblmetazoa:FBtr0086032(transcript)|go:"GO:0000776"(kinetochore)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0007065"(male meiosis sister chromatid cohesion)|go:"GO:0007066"(female meiosis sister chromatid cohesion)|go:"GO:0007094"(mitotic spindle assembly checkpoint signaling)|go:"GO:0007096"(regulation of exit from mitosis)|go:"GO:0010965"(regulation of mitotic sister chromatid separation)|go:"GO:0031937"(obsolete positive regulation of chromatin silencing)|go:"GO:0051754"(meiotic sister chromatid cohesion, centromeric)|go:"GO:0070193"(synaptonemal complex organization)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013212(Mad3/BUB1 homology region 1)|interpro:IPR015661(Mitotic checkpoint serine/threonine protein kinase, Bub1)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:A1Z6I7|rcsb pdb:6JKK|rcsb pdb:6JKM|reactome:R-DME-141430|reactome:R-DME-174184|reactome:R-DME-176409|reactome:R-DME-179409|flybase:FBgn0263855	-	-	-	figure legend:f6c f7c|comment:"cells  overexpressing Mps1 and treated with colchicine, co-immunoprecipitated  significantly higher levels of BubR1 with  Cdc20 than non-induced control cells (Figure 7C) further  supporting a model in which Mps1-regulated phosphorylation  of BubR1 is instrumental for the formation of the Cdc20-  BubR1 complex, which in turn is required for MCC assembly  and sustained SAC function."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:7227(drome-schneider_2)|taxid:7227(Drosophila melanogaster late embryo cells)	-	2013/10/16	2014/10/16	rogid:o3IV0N/UEpFvqMOFNx4/bxLUUV87227	rogid:oYFJqxeFO6p6FB/pk1ZKfRONMTw7227	intact-crc:76CFCCDEDD9DB88C|rigid:B/cD2u7zYkaYfbA3/5YLlCS+R5g	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)