#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q8K4S1	uniprotkb:E9Q401	intact:EBI-6902760|ensembl:ENSMUSP00000130604|ensembl:ENSMUSP00000138360|uniprotkb:B9EHS1|uniprotkb:E9Q5G0|uniprotkb:Q3TS68|uniprotkb:Q80TC4|uniprotkb:Q8BZF3|uniprotkb:Q9JKM2	intact:EBI-643628|ensembl:ENSMUSP00000021750|uniprotkb:O70181|uniprotkb:Q62174|uniprotkb:Q62197|uniprotkb:Q9ERN6	psi-mi:plce1_mouse(display_long)|uniprotkb:Plce1(gene name)|psi-mi:Plce1(display_short)|uniprotkb:Kiaa1516(gene name synonym)|uniprotkb:Plce(gene name synonym)|uniprotkb:Phosphoinositide phospholipase C-epsilon-1(gene name synonym)|uniprotkb:Phospholipase C-epsilon-1(gene name synonym)	psi-mi:ryr2_mouse(display_long)|uniprotkb:Ryr2(gene name)|psi-mi:Ryr2(display_short)|uniprotkb:Cardiac muscle ryanodine receptor(gene name synonym)|uniprotkb:Cardiac muscle ryanodine receptor-calcium release channel(gene name synonym)|uniprotkb:Type 2 ryanodine receptor(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Zhang et al. (2013)	pubmed:23540699|imex:IM-24164	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6903715|imex:IM-24164-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011245682.1|ensembl:ENSMUSG00000024998(gene)|ensembl:ENSMUST00000169713(transcript)|ensembl:ENSMUST00000182481(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0004435"(phosphatidylinositol phospholipase C activity)|go:"GO:0004629"(phospholipase C activity)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006651"(diacylglycerol biosynthetic process)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007200"(phospholipase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0016042"(lipid catabolic process)|go:"GO:0019899"(enzyme binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032835"(glomerulus development)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0046578"(regulation of Ras protein signal transduction)|go:"GO:0046872"(metal ion binding)|go:"GO:0048015"(phosphatidylinositol-mediated signaling)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000159(Ras-association)|interpro:IPR000909(Phospholipase C, phosphatidylinositol-specific , X region)|interpro:IPR001192("Phospholipase C, phosphoinositol-specific, C-terminal (PLC)")|interpro:IPR001711(Phospholipase C, phosphatidylinositol-specific, Y domain)|interpro:IPR001895(Guanine-nucleotide dissociation stimulator CDC25)|interpro:IPR011992(EF-Hand type)|interpro:IPR015359(Phospholipase C, phosphoinositol-specific, EF-hand-like)|interpro:IPR017946|interpro:IPR023578|interpro:IPR028398|interpro:IPR029071|interpro:IPR035892|mint:Q8K4S1|reactome:R-MMU-1855204|go:"GO:0008277"(regulation of G protein-coupled receptor signaling pathway)|refseq:NP_062534.2|dip:DIP-60738N	refseq:NP_076357.2|go:"GO:0071872"(cellular response to epinephrine stimulus)|go:"GO:0072599"(establishment of protein localization to endoplasmic reticulum)|go:"GO:0086005"(ventricular cardiac muscle cell action potential)|go:"GO:0086029"(Purkinje myocyte to ventricular cardiac muscle cell signaling)|go:"GO:0097050"(type B pancreatic cell apoptotic process)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0071421"(manganese ion transmembrane transport)|go:"GO:0097159"(organic cyclic compound binding)|go:"GO:0098735"(positive regulation of the force of heart contraction)|go:"GO:0098904"(regulation of AV node cell action potential)|go:"GO:0098907"(regulation of SA node cell action potential)|go:"GO:0098910"(regulation of atrial cardiac muscle cell action potential)|go:"GO:0098911"(regulation of ventricular cardiac muscle cell action potential)|go:"GO:1901896"(positive regulation of ATPase-coupled calcium transmembrane transporter activity)|interpro:IPR000699(Intracellular calcium-release channel)|interpro:IPR001870("B302 (SPRY)-like")|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR003032(Ryanodine receptor Ryr)|interpro:IPR003877(SPla/RYanodine receptor SPRY)|interpro:IPR005821(Ion transport)|interpro:IPR009460(Ryanodine Receptor TM 4-6)|interpro:IPR011992(EF-Hand type)|go:"GO:0005886"(plasma membrane)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0010460"(positive regulation of heart rate)|go:"GO:0010881"(regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014808"(release of sequestered calcium ion into cytosol by sarcoplasmic reticulum)|go:"GO:0014850"(response to muscle activity)|go:"GO:0015278"(calcium-release channel activity)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031000"(response to caffeine)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031672"(A band)|go:"GO:0032026"(response to magnesium ion)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033017"(sarcoplasmic reticulum membrane)|go:"GO:0034220"(ion transmembrane transport)|go:"GO:0034236"(protein kinase A catalytic subunit binding)|go:"GO:0034237"(protein kinase A regulatory subunit binding)|go:"GO:0034704"(calcium channel complex)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0035994"(response to muscle stretch)|go:"GO:0042383"(sarcolemma)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043621"(protein self-association)|go:"GO:0043924"(suramin binding)|go:"GO:0048763"(calcium-induced calcium release activity)|go:"GO:0051209"(release of sequestered calcium ion into cytosol)|go:"GO:0051284"(positive regulation of sequestering of calcium ion)|go:"GO:0051480"(regulation of cytosolic calcium ion concentration)|go:"GO:0051481"(negative regulation of cytosolic calcium ion concentration)|go:"GO:0051592"(response to calcium ion)|go:"GO:0051775"(response to redox state)|go:"GO:0055117"(regulation of cardiac muscle contraction)|go:"GO:0060048"(cardiac muscle contraction)|go:"GO:0060401"(cytosolic calcium ion transport)|go:"GO:0060402"(calcium ion transport into cytosol)|go:"GO:0070296"(sarcoplasmic reticulum calcium ion transport)|go:"GO:0070588"(calcium ion transmembrane transport)|go:"GO:0071313"(cellular response to caffeine)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|rcsb pdb:4ETV|rcsb pdb:4KEI|rcsb pdb:4KEJ|rcsb pdb:4KEK|rcsb pdb:4L4H|interpro:IPR013333(Ryanodine receptor, N-terminal)|rcsb pdb:4L4I|rcsb pdb:4P9I|interpro:IPR013662(RyR and IP3R Homology associated)|rcsb pdb:4P9L|interpro:IPR014821(Inositol 1,4,5-trisphosphate/ryanodine receptor)|rcsb pdb:5C33|rcsb pdb:5VSN|rcsb pdb:6J6L|rcsb pdb:6MM5|rcsb pdb:6MM6|rcsb pdb:6MM7|interpro:IPR016093(MIR motif)|rcsb pdb:6MM8|interpro:IPR035761|rcsb pdb:6WOU|rcsb pdb:6WOV|reactome:R-MMU-2672351|interpro:IPR035762|reactome:R-MMU-5578775|interpro:IPR035764|interpro:IPR035910|interpro:IPR036300|interpro:IPR043136|mint:E9Q401|rcsb pdb:2MC2|rcsb pdb:3IM5|rcsb pdb:3IM6|rcsb pdb:3IM7|rcsb pdb:3QR5|ensembl:ENSMUSG00000021313(gene)|ensembl:ENSMUST00000021750(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002027"(regulation of heart rate)|go:"GO:0003143"(embryonic heart tube morphogenesis)|go:"GO:0003220"(left ventricular cardiac muscle tissue morphogenesis)|go:"GO:0003300"(cardiac muscle hypertrophy)|go:"GO:0005219"(ryanodine-sensitive calcium-release channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005513"(detection of calcium ion)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005790"(smooth endoplasmic reticulum)	-	-	-	figure legend:Fig. 3C, 3E|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-heart)|taxid:10090(Mus musculus heart [Cardiac; Cardiac tissue])	-	2013/07/26	2015/10/08	rogid:Rr4ZpeiD2udZg0JtqD/b7CRGi/Y10090	rogid:HHxj8k5HJe0bbt0o041H0inQo0w10090	intact-crc:16DF484839164FCE|rigid:lDg8R80FAh2X3QEieiokqtIdaZ0	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q8K4S1	uniprotkb:Q62101	intact:EBI-6902760|ensembl:ENSMUSP00000130604|ensembl:ENSMUSP00000138360|uniprotkb:B9EHS1|uniprotkb:E9Q5G0|uniprotkb:Q3TS68|uniprotkb:Q80TC4|uniprotkb:Q8BZF3|uniprotkb:Q9JKM2	intact:EBI-6903636|uniprotkb:E9QNA3|ensembl:ENSMUSP00000002765	psi-mi:plce1_mouse(display_long)|uniprotkb:Plce1(gene name)|psi-mi:Plce1(display_short)|uniprotkb:Kiaa1516(gene name synonym)|uniprotkb:Plce(gene name synonym)|uniprotkb:Phosphoinositide phospholipase C-epsilon-1(gene name synonym)|uniprotkb:Phospholipase C-epsilon-1(gene name synonym)	psi-mi:kpcd1_mouse(display_long)|uniprotkb:Prkd1(gene name)|psi-mi:Prkd1(display_short)|uniprotkb:Pkcm(gene name synonym)|uniprotkb:Pkd(gene name synonym)|uniprotkb:Prkcm(gene name synonym)|uniprotkb:Protein kinase C mu type(gene name synonym)|uniprotkb:Protein kinase D(gene name synonym)|uniprotkb:nPKC-D1(gene name synonym)|uniprotkb:nPKC-mu(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Zhang et al. (2013)	pubmed:23540699|imex:IM-24164	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6903715|imex:IM-24164-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011245682.1|ensembl:ENSMUSG00000024998(gene)|ensembl:ENSMUST00000169713(transcript)|ensembl:ENSMUST00000182481(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0004435"(phosphatidylinositol phospholipase C activity)|go:"GO:0004629"(phospholipase C activity)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006651"(diacylglycerol biosynthetic process)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007200"(phospholipase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0016042"(lipid catabolic process)|go:"GO:0019899"(enzyme binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032835"(glomerulus development)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0046578"(regulation of Ras protein signal transduction)|go:"GO:0046872"(metal ion binding)|go:"GO:0048015"(phosphatidylinositol-mediated signaling)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000159(Ras-association)|interpro:IPR000909(Phospholipase C, phosphatidylinositol-specific , X region)|interpro:IPR001192("Phospholipase C, phosphoinositol-specific, C-terminal (PLC)")|interpro:IPR001711(Phospholipase C, phosphatidylinositol-specific, Y domain)|interpro:IPR001895(Guanine-nucleotide dissociation stimulator CDC25)|interpro:IPR011992(EF-Hand type)|interpro:IPR015359(Phospholipase C, phosphoinositol-specific, EF-hand-like)|interpro:IPR017946|interpro:IPR023578|interpro:IPR028398|interpro:IPR029071|interpro:IPR035892|mint:Q8K4S1|reactome:R-MMU-1855204|go:"GO:0008277"(regulation of G protein-coupled receptor signaling pathway)|refseq:NP_062534.2|dip:DIP-60738N	ensembl:ENSMUSG00000002688(gene)|ensembl:ENSMUST00000002765(transcript)|go:"GO:0000421"(autophagosome membrane)|go:"GO:0001525"(angiogenesis)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004697"(protein kinase C activity)|go:"GO:0004698"(calcium-dependent protein kinase C activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005938"(cell cortex)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0007030"(Golgi organization)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007399"(nervous system development)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010837"(regulation of keratinocyte proliferation)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0016301"(kinase activity)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0030154"(cell differentiation)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032793"(positive regulation of CREB transcription factor activity)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|go:"GO:0038033"(positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042802"(identical protein binding)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0045087"(innate immune response)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|go:"GO:0048193"(Golgi vesicle transport)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051279"(regulation of release of sequestered calcium ion into cytosol)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0071447"(cellular response to hydroperoxide)|go:"GO:0089700"(protein kinase D signaling)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1901727"(positive regulation of histone deacetylase activity)|go:"GO:2001028"(positive regulation of endothelial cell chemotaxis)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR015727(Protein kinase C mu-related)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020454|reactome:R-MMU-1660661|refseq:NP_032884.2	-	-	-	figure legend:Fig. 3C, 3E|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-heart)|taxid:10090(Mus musculus heart [Cardiac; Cardiac tissue])	-	2013/07/26	2015/10/08	rogid:Rr4ZpeiD2udZg0JtqD/b7CRGi/Y10090	rogid:xK0iuWlHzuSTL3EQK0HGc2YPjdI10090	intact-crc:16DF484839164FCE|rigid:lDg8R80FAh2X3QEieiokqtIdaZ0	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:E9Q9K8	uniprotkb:Q8VCC8	intact:EBI-6902745|ensembl:ENSMUSP00000093406	intact:EBI-6902706|ensembl:ENSMUSP00000118148|uniprotkb:Q8BZK9|uniprotkb:Q8R1R1	psi-mi:e9q9k8_mouse(display_long)|uniprotkb:Akap6(gene name)|psi-mi:Akap6(display_short)	psi-mi:rpgf3_mouse(display_long)|uniprotkb:Rapgef3(gene name)|psi-mi:Rapgef3(display_short)|uniprotkb:Epac(gene name synonym)|uniprotkb:Epac1(gene name synonym)|uniprotkb:Exchange factor directly activated by cAMP 1(gene name synonym)|uniprotkb:Exchange protein directly activated by cAMP 1(gene name synonym)|uniprotkb:cAMP-regulated guanine nucleotide exchange factor I(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Zhang et al. (2013)	pubmed:23540699|imex:IM-24164	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6903697|imex:IM-24164-9	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUST00000095737(transcript)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005737"(cytoplasm)|go:"GO:0005901"(caveola)|go:"GO:0007194"(negative regulation of adenylate cyclase activity)|go:"GO:0008179"(adenylate cyclase binding)|go:"GO:0010738"(regulation of protein kinase A signaling)|go:"GO:0014701"(junctional sarcoplasmic reticulum membrane)|go:"GO:0014704"(intercalated disc)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0019899"(enzyme binding)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030315"(T-tubule)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034237"(protein kinase A regulatory subunit binding)|go:"GO:0034629"|go:"GO:0034704"(calcium channel complex)|go:"GO:0042383"(sarcolemma)|go:"GO:0043495"(protein-membrane adaptor activity)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051018"(protein kinase A binding)|go:"GO:0051281"(positive regulation of release of sequestered calcium ion into cytosol)|go:"GO:0051721"(protein phosphatase 2A binding)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0060306"(regulation of membrane repolarization)|go:"GO:0060316"(positive regulation of ryanodine-sensitive calcium-release channel activity)|go:"GO:0061051"(positive regulation of cell growth involved in cardiac muscle cell development)|go:"GO:0070886"(positive regulation of calcineurin-NFAT signaling cascade)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0071872"(cellular response to epinephrine stimulus)|go:"GO:0086004"(regulation of cardiac muscle cell contraction)|go:"GO:1901381"(positive regulation of potassium ion transmembrane transport)|go:"GO:1901897"(regulation of relaxation of cardiac muscle)|go:"GO:1902261"(positive regulation of delayed rectifier potassium channel activity)|go:"GO:2000481"(positive regulation of cAMP-dependent protein kinase activity)|interpro:IPR018159|interpro:IPR002017(Spectrin repeat)|refseq:XP_006515891.1|ensembl:ENSMUSG00000061603(gene)|refseq:NP_932779.2	ensembl:ENSMUSG00000022469(gene)|ensembl:ENSMUST00000129223(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005902"(microvillus)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0010667"(negative regulation of cardiac muscle cell apoptotic process)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0019904"(protein domain specific binding)|go:"GO:1901985"(positive regulation of protein acetylation)|go:"GO:1904426"(positive regulation of GTP binding)|go:"GO:1904427"(positive regulation of calcium ion transmembrane transport)|go:"GO:1904453"("positive regulation of potassium:proton exchanging ATPase activity")|go:"GO:1990794"(basolateral part of cell)|go:"GO:1990795"(rod bipolar cell terminal bouton)|go:"GO:1990796"(photoreceptor cell terminal bouton)|go:"GO:2000249"(regulation of actin cytoskeleton reorganization)|go:"GO:2000251"(positive regulation of actin cytoskeleton reorganization)|interpro:IPR000591(Pleckstrin/ G-protein, interacting region)|interpro:IPR000595(Cyclic nucleotide-binding)|interpro:IPR000651(Guanine nucleotide exchange factor for Ras-like GTPases, N-terminal)|interpro:IPR001895(Guanine-nucleotide dissociation stimulator CDC25)|interpro:IPR008937(Ras guanine nucleotide exchange factor)|interpro:IPR014710(RmlC-like jelly roll fold)|interpro:IPR018490|interpro:IPR019804|interpro:IPR023578|interpro:IPR029071|interpro:IPR036388|interpro:IPR036390|interpro:IPR036964|reactome:R-MMU-354192|reactome:R-MMU-381676|reactome:R-MMU-392517|reactome:R-MMU-422356|go:"GO:0030027"(lamellipodium)|go:"GO:0030175"(filopodium)|go:"GO:0030426"(growth cone)|go:"GO:0030552"(cAMP binding)|go:"GO:0030864"(cortical actin cytoskeleton)|go:"GO:0031090"(organelle membrane)|go:"GO:0031526"(brush border membrane)|go:"GO:0032486"(Rap protein signal transduction)|go:"GO:0032966"(negative regulation of collagen biosynthetic process)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034242"(negative regulation of syncytium formation by plasma membrane fusion)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0043679"(axon terminus)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045177"(apical part of cell)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045793"(positive regulation of cell size)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046827"(positive regulation of protein export from nucleus)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0060143"(positive regulation of syncytium formation by plasma membrane fusion)|go:"GO:0061028"(establishment of endothelial barrier)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071944"(cell periphery)|go:"GO:0097470"(ribbon synapse)|refseq:NP_001171281.1|refseq:NP_001171282.1|refseq:NP_659099.2	-	-	-	figure legend:Fig. 3B, 3D|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-heart)|taxid:10090(Mus musculus heart [Cardiac; Cardiac tissue])	-	2013/07/26	2015/05/15	rogid:Lgqd30LMPt/TCef2Ywd7Txbv4PY10090	rogid:/oPx4MYIucBVmp8orJpX4EIBEAc10090	intact-crc:24457D863704846E|rigid:CyAJLMfcZHVcizMcQgB3gO2If28	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:E9Q9K8	uniprotkb:Q62101	intact:EBI-6902745|ensembl:ENSMUSP00000093406	intact:EBI-6903636|uniprotkb:E9QNA3|ensembl:ENSMUSP00000002765	psi-mi:e9q9k8_mouse(display_long)|uniprotkb:Akap6(gene name)|psi-mi:Akap6(display_short)	psi-mi:kpcd1_mouse(display_long)|uniprotkb:Prkd1(gene name)|psi-mi:Prkd1(display_short)|uniprotkb:Pkcm(gene name synonym)|uniprotkb:Pkd(gene name synonym)|uniprotkb:Prkcm(gene name synonym)|uniprotkb:Protein kinase C mu type(gene name synonym)|uniprotkb:Protein kinase D(gene name synonym)|uniprotkb:nPKC-D1(gene name synonym)|uniprotkb:nPKC-mu(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Zhang et al. (2013)	pubmed:23540699|imex:IM-24164	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6903697|imex:IM-24164-9	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUST00000095737(transcript)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005737"(cytoplasm)|go:"GO:0005901"(caveola)|go:"GO:0007194"(negative regulation of adenylate cyclase activity)|go:"GO:0008179"(adenylate cyclase binding)|go:"GO:0010738"(regulation of protein kinase A signaling)|go:"GO:0014701"(junctional sarcoplasmic reticulum membrane)|go:"GO:0014704"(intercalated disc)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0019899"(enzyme binding)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030315"(T-tubule)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034237"(protein kinase A regulatory subunit binding)|go:"GO:0034629"|go:"GO:0034704"(calcium channel complex)|go:"GO:0042383"(sarcolemma)|go:"GO:0043495"(protein-membrane adaptor activity)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051018"(protein kinase A binding)|go:"GO:0051281"(positive regulation of release of sequestered calcium ion into cytosol)|go:"GO:0051721"(protein phosphatase 2A binding)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0060306"(regulation of membrane repolarization)|go:"GO:0060316"(positive regulation of ryanodine-sensitive calcium-release channel activity)|go:"GO:0061051"(positive regulation of cell growth involved in cardiac muscle cell development)|go:"GO:0070886"(positive regulation of calcineurin-NFAT signaling cascade)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0071872"(cellular response to epinephrine stimulus)|go:"GO:0086004"(regulation of cardiac muscle cell contraction)|go:"GO:1901381"(positive regulation of potassium ion transmembrane transport)|go:"GO:1901897"(regulation of relaxation of cardiac muscle)|go:"GO:1902261"(positive regulation of delayed rectifier potassium channel activity)|go:"GO:2000481"(positive regulation of cAMP-dependent protein kinase activity)|interpro:IPR018159|interpro:IPR002017(Spectrin repeat)|refseq:XP_006515891.1|ensembl:ENSMUSG00000061603(gene)|refseq:NP_932779.2	ensembl:ENSMUSG00000002688(gene)|ensembl:ENSMUST00000002765(transcript)|go:"GO:0000421"(autophagosome membrane)|go:"GO:0001525"(angiogenesis)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004697"(protein kinase C activity)|go:"GO:0004698"(calcium-dependent protein kinase C activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005938"(cell cortex)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0007030"(Golgi organization)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007399"(nervous system development)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010837"(regulation of keratinocyte proliferation)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0016301"(kinase activity)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0030154"(cell differentiation)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032793"(positive regulation of CREB transcription factor activity)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|go:"GO:0038033"(positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042802"(identical protein binding)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0045087"(innate immune response)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|go:"GO:0048193"(Golgi vesicle transport)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051279"(regulation of release of sequestered calcium ion into cytosol)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0071447"(cellular response to hydroperoxide)|go:"GO:0089700"(protein kinase D signaling)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1901727"(positive regulation of histone deacetylase activity)|go:"GO:2001028"(positive regulation of endothelial cell chemotaxis)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR015727(Protein kinase C mu-related)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020454|reactome:R-MMU-1660661|refseq:NP_032884.2	-	-	-	figure legend:Fig. 3B, 3D|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-heart)|taxid:10090(Mus musculus heart [Cardiac; Cardiac tissue])	-	2013/07/26	2015/05/15	rogid:Lgqd30LMPt/TCef2Ywd7Txbv4PY10090	rogid:xK0iuWlHzuSTL3EQK0HGc2YPjdI10090	intact-crc:24457D863704846E|rigid:CyAJLMfcZHVcizMcQgB3gO2If28	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q8VCC8	uniprotkb:E9Q9K8	intact:EBI-6902706|ensembl:ENSMUSP00000118148|uniprotkb:Q8BZK9|uniprotkb:Q8R1R1	intact:EBI-6902745|ensembl:ENSMUSP00000093406	psi-mi:rpgf3_mouse(display_long)|uniprotkb:Rapgef3(gene name)|psi-mi:Rapgef3(display_short)|uniprotkb:Epac(gene name synonym)|uniprotkb:Epac1(gene name synonym)|uniprotkb:Exchange factor directly activated by cAMP 1(gene name synonym)|uniprotkb:Exchange protein directly activated by cAMP 1(gene name synonym)|uniprotkb:cAMP-regulated guanine nucleotide exchange factor I(gene name synonym)	psi-mi:e9q9k8_mouse(display_long)|uniprotkb:Akap6(gene name)|psi-mi:Akap6(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Zhang et al. (2013)	pubmed:23540699|imex:IM-24164	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6903521|imex:IM-24164-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000022469(gene)|ensembl:ENSMUST00000129223(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005902"(microvillus)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0010667"(negative regulation of cardiac muscle cell apoptotic process)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0019904"(protein domain specific binding)|go:"GO:1901985"(positive regulation of protein acetylation)|go:"GO:1904426"(positive regulation of GTP binding)|go:"GO:1904427"(positive regulation of calcium ion transmembrane transport)|go:"GO:1904453"("positive regulation of potassium:proton exchanging ATPase activity")|go:"GO:1990794"(basolateral part of cell)|go:"GO:1990795"(rod bipolar cell terminal bouton)|go:"GO:1990796"(photoreceptor cell terminal bouton)|go:"GO:2000249"(regulation of actin cytoskeleton reorganization)|go:"GO:2000251"(positive regulation of actin cytoskeleton reorganization)|interpro:IPR000591(Pleckstrin/ G-protein, interacting region)|interpro:IPR000595(Cyclic nucleotide-binding)|interpro:IPR000651(Guanine nucleotide exchange factor for Ras-like GTPases, N-terminal)|interpro:IPR001895(Guanine-nucleotide dissociation stimulator CDC25)|interpro:IPR008937(Ras guanine nucleotide exchange factor)|interpro:IPR014710(RmlC-like jelly roll fold)|interpro:IPR018490|interpro:IPR019804|interpro:IPR023578|interpro:IPR029071|interpro:IPR036388|interpro:IPR036390|interpro:IPR036964|reactome:R-MMU-354192|reactome:R-MMU-381676|reactome:R-MMU-392517|reactome:R-MMU-422356|go:"GO:0030027"(lamellipodium)|go:"GO:0030175"(filopodium)|go:"GO:0030426"(growth cone)|go:"GO:0030552"(cAMP binding)|go:"GO:0030864"(cortical actin cytoskeleton)|go:"GO:0031090"(organelle membrane)|go:"GO:0031526"(brush border membrane)|go:"GO:0032486"(Rap protein signal transduction)|go:"GO:0032966"(negative regulation of collagen biosynthetic process)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034242"(negative regulation of syncytium formation by plasma membrane fusion)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0043679"(axon terminus)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045177"(apical part of cell)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045793"(positive regulation of cell size)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046827"(positive regulation of protein export from nucleus)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0060143"(positive regulation of syncytium formation by plasma membrane fusion)|go:"GO:0061028"(establishment of endothelial barrier)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071944"(cell periphery)|go:"GO:0097470"(ribbon synapse)|refseq:NP_001171281.1|refseq:NP_001171282.1|refseq:NP_659099.2	ensembl:ENSMUST00000095737(transcript)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005737"(cytoplasm)|go:"GO:0005901"(caveola)|go:"GO:0007194"(negative regulation of adenylate cyclase activity)|go:"GO:0008179"(adenylate cyclase binding)|go:"GO:0010738"(regulation of protein kinase A signaling)|go:"GO:0014701"(junctional sarcoplasmic reticulum membrane)|go:"GO:0014704"(intercalated disc)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0019899"(enzyme binding)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030315"(T-tubule)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034237"(protein kinase A regulatory subunit binding)|go:"GO:0034629"|go:"GO:0034704"(calcium channel complex)|go:"GO:0042383"(sarcolemma)|go:"GO:0043495"(protein-membrane adaptor activity)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051018"(protein kinase A binding)|go:"GO:0051281"(positive regulation of release of sequestered calcium ion into cytosol)|go:"GO:0051721"(protein phosphatase 2A binding)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0060306"(regulation of membrane repolarization)|go:"GO:0060316"(positive regulation of ryanodine-sensitive calcium-release channel activity)|go:"GO:0061051"(positive regulation of cell growth involved in cardiac muscle cell development)|go:"GO:0070886"(positive regulation of calcineurin-NFAT signaling cascade)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0071872"(cellular response to epinephrine stimulus)|go:"GO:0086004"(regulation of cardiac muscle cell contraction)|go:"GO:1901381"(positive regulation of potassium ion transmembrane transport)|go:"GO:1901897"(regulation of relaxation of cardiac muscle)|go:"GO:1902261"(positive regulation of delayed rectifier potassium channel activity)|go:"GO:2000481"(positive regulation of cAMP-dependent protein kinase activity)|interpro:IPR018159|interpro:IPR002017(Spectrin repeat)|refseq:XP_006515891.1|ensembl:ENSMUSG00000061603(gene)|refseq:NP_932779.2	-	-	-	comment:Interaction observed in PLCE1-/- cells|figure legend:Fig. 3B, 3D, Supp. Fig. 2C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-heart)|taxid:10090(Mus musculus heart [Cardiac; Cardiac tissue])	-	2013/07/26	2015/05/15	rogid:/oPx4MYIucBVmp8orJpX4EIBEAc10090	rogid:Lgqd30LMPt/TCef2Ywd7Txbv4PY10090	intact-crc:F4AD8F876D9EB2FA|rigid:ZZHGWpNAhbSIyd+Nqz9sB+sDJy0	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q8K4S1	uniprotkb:E9Q401	intact:EBI-6902760|ensembl:ENSMUSP00000130604|ensembl:ENSMUSP00000138360|uniprotkb:B9EHS1|uniprotkb:E9Q5G0|uniprotkb:Q3TS68|uniprotkb:Q80TC4|uniprotkb:Q8BZF3|uniprotkb:Q9JKM2	intact:EBI-643628|ensembl:ENSMUSP00000021750|uniprotkb:O70181|uniprotkb:Q62174|uniprotkb:Q62197|uniprotkb:Q9ERN6	psi-mi:plce1_mouse(display_long)|uniprotkb:Plce1(gene name)|psi-mi:Plce1(display_short)|uniprotkb:Kiaa1516(gene name synonym)|uniprotkb:Plce(gene name synonym)|uniprotkb:Phosphoinositide phospholipase C-epsilon-1(gene name synonym)|uniprotkb:Phospholipase C-epsilon-1(gene name synonym)	psi-mi:ryr2_mouse(display_long)|uniprotkb:Ryr2(gene name)|psi-mi:Ryr2(display_short)|uniprotkb:Cardiac muscle ryanodine receptor(gene name synonym)|uniprotkb:Cardiac muscle ryanodine receptor-calcium release channel(gene name synonym)|uniprotkb:Type 2 ryanodine receptor(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Zhang et al. (2013)	pubmed:23540699|imex:IM-24164	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6902823|imex:IM-24164-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011245682.1|ensembl:ENSMUSG00000024998(gene)|ensembl:ENSMUST00000169713(transcript)|ensembl:ENSMUST00000182481(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0004435"(phosphatidylinositol phospholipase C activity)|go:"GO:0004629"(phospholipase C activity)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006651"(diacylglycerol biosynthetic process)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007200"(phospholipase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0016042"(lipid catabolic process)|go:"GO:0019899"(enzyme binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032835"(glomerulus development)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0046578"(regulation of Ras protein signal transduction)|go:"GO:0046872"(metal ion binding)|go:"GO:0048015"(phosphatidylinositol-mediated signaling)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000159(Ras-association)|interpro:IPR000909(Phospholipase C, phosphatidylinositol-specific , X region)|interpro:IPR001192("Phospholipase C, phosphoinositol-specific, C-terminal (PLC)")|interpro:IPR001711(Phospholipase C, phosphatidylinositol-specific, Y domain)|interpro:IPR001895(Guanine-nucleotide dissociation stimulator CDC25)|interpro:IPR011992(EF-Hand type)|interpro:IPR015359(Phospholipase C, phosphoinositol-specific, EF-hand-like)|interpro:IPR017946|interpro:IPR023578|interpro:IPR028398|interpro:IPR029071|interpro:IPR035892|mint:Q8K4S1|reactome:R-MMU-1855204|go:"GO:0008277"(regulation of G protein-coupled receptor signaling pathway)|refseq:NP_062534.2|dip:DIP-60738N	refseq:NP_076357.2|go:"GO:0071872"(cellular response to epinephrine stimulus)|go:"GO:0072599"(establishment of protein localization to endoplasmic reticulum)|go:"GO:0086005"(ventricular cardiac muscle cell action potential)|go:"GO:0086029"(Purkinje myocyte to ventricular cardiac muscle cell signaling)|go:"GO:0097050"(type B pancreatic cell apoptotic process)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0071421"(manganese ion transmembrane transport)|go:"GO:0097159"(organic cyclic compound binding)|go:"GO:0098735"(positive regulation of the force of heart contraction)|go:"GO:0098904"(regulation of AV node cell action potential)|go:"GO:0098907"(regulation of SA node cell action potential)|go:"GO:0098910"(regulation of atrial cardiac muscle cell action potential)|go:"GO:0098911"(regulation of ventricular cardiac muscle cell action potential)|go:"GO:1901896"(positive regulation of ATPase-coupled calcium transmembrane transporter activity)|interpro:IPR000699(Intracellular calcium-release channel)|interpro:IPR001870("B302 (SPRY)-like")|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR003032(Ryanodine receptor Ryr)|interpro:IPR003877(SPla/RYanodine receptor SPRY)|interpro:IPR005821(Ion transport)|interpro:IPR009460(Ryanodine Receptor TM 4-6)|interpro:IPR011992(EF-Hand type)|go:"GO:0005886"(plasma membrane)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0010460"(positive regulation of heart rate)|go:"GO:0010881"(regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014808"(release of sequestered calcium ion into cytosol by sarcoplasmic reticulum)|go:"GO:0014850"(response to muscle activity)|go:"GO:0015278"(calcium-release channel activity)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031000"(response to caffeine)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031672"(A band)|go:"GO:0032026"(response to magnesium ion)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033017"(sarcoplasmic reticulum membrane)|go:"GO:0034220"(ion transmembrane transport)|go:"GO:0034236"(protein kinase A catalytic subunit binding)|go:"GO:0034237"(protein kinase A regulatory subunit binding)|go:"GO:0034704"(calcium channel complex)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0035994"(response to muscle stretch)|go:"GO:0042383"(sarcolemma)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043621"(protein self-association)|go:"GO:0043924"(suramin binding)|go:"GO:0048763"(calcium-induced calcium release activity)|go:"GO:0051209"(release of sequestered calcium ion into cytosol)|go:"GO:0051284"(positive regulation of sequestering of calcium ion)|go:"GO:0051480"(regulation of cytosolic calcium ion concentration)|go:"GO:0051481"(negative regulation of cytosolic calcium ion concentration)|go:"GO:0051592"(response to calcium ion)|go:"GO:0051775"(response to redox state)|go:"GO:0055117"(regulation of cardiac muscle contraction)|go:"GO:0060048"(cardiac muscle contraction)|go:"GO:0060401"(cytosolic calcium ion transport)|go:"GO:0060402"(calcium ion transport into cytosol)|go:"GO:0070296"(sarcoplasmic reticulum calcium ion transport)|go:"GO:0070588"(calcium ion transmembrane transport)|go:"GO:0071313"(cellular response to caffeine)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|rcsb pdb:4ETV|rcsb pdb:4KEI|rcsb pdb:4KEJ|rcsb pdb:4KEK|rcsb pdb:4L4H|interpro:IPR013333(Ryanodine receptor, N-terminal)|rcsb pdb:4L4I|rcsb pdb:4P9I|interpro:IPR013662(RyR and IP3R Homology associated)|rcsb pdb:4P9L|interpro:IPR014821(Inositol 1,4,5-trisphosphate/ryanodine receptor)|rcsb pdb:5C33|rcsb pdb:5VSN|rcsb pdb:6J6L|rcsb pdb:6MM5|rcsb pdb:6MM6|rcsb pdb:6MM7|interpro:IPR016093(MIR motif)|rcsb pdb:6MM8|interpro:IPR035761|rcsb pdb:6WOU|rcsb pdb:6WOV|reactome:R-MMU-2672351|interpro:IPR035762|reactome:R-MMU-5578775|interpro:IPR035764|interpro:IPR035910|interpro:IPR036300|interpro:IPR043136|mint:E9Q401|rcsb pdb:2MC2|rcsb pdb:3IM5|rcsb pdb:3IM6|rcsb pdb:3IM7|rcsb pdb:3QR5|ensembl:ENSMUSG00000021313(gene)|ensembl:ENSMUST00000021750(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002027"(regulation of heart rate)|go:"GO:0003143"(embryonic heart tube morphogenesis)|go:"GO:0003220"(left ventricular cardiac muscle tissue morphogenesis)|go:"GO:0003300"(cardiac muscle hypertrophy)|go:"GO:0005219"(ryanodine-sensitive calcium-release channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005513"(detection of calcium ion)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005790"(smooth endoplasmic reticulum)	-	-	-	comment:Interaction observed in the absence of AKAP6-/- cells|figure legend:Fig. 3B, Supp Fig. 2D|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-heart)|taxid:10090(Mus musculus heart [Cardiac; Cardiac tissue])	-	2013/07/26	2015/05/15	rogid:Rr4ZpeiD2udZg0JtqD/b7CRGi/Y10090	rogid:HHxj8k5HJe0bbt0o041H0inQo0w10090	intact-crc:CC7B68A369CD8E4F|rigid:OcvnVafYUCBRiAZyedW+Ryb/PV0	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:E9Q401	uniprotkb:E9Q9K8	intact:EBI-643628|ensembl:ENSMUSP00000021750|uniprotkb:O70181|uniprotkb:Q62174|uniprotkb:Q62197|uniprotkb:Q9ERN6	intact:EBI-6902745|ensembl:ENSMUSP00000093406	psi-mi:ryr2_mouse(display_long)|uniprotkb:Ryr2(gene name)|psi-mi:Ryr2(display_short)|uniprotkb:Cardiac muscle ryanodine receptor(gene name synonym)|uniprotkb:Cardiac muscle ryanodine receptor-calcium release channel(gene name synonym)|uniprotkb:Type 2 ryanodine receptor(gene name synonym)	psi-mi:e9q9k8_mouse(display_long)|uniprotkb:Akap6(gene name)|psi-mi:Akap6(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Zhang et al. (2013)	pubmed:23540699|imex:IM-24164	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-10822159|imex:IM-24164-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_076357.2|go:"GO:0071872"(cellular response to epinephrine stimulus)|go:"GO:0072599"(establishment of protein localization to endoplasmic reticulum)|go:"GO:0086005"(ventricular cardiac muscle cell action potential)|go:"GO:0086029"(Purkinje myocyte to ventricular cardiac muscle cell signaling)|go:"GO:0097050"(type B pancreatic cell apoptotic process)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0071421"(manganese ion transmembrane transport)|go:"GO:0097159"(organic cyclic compound binding)|go:"GO:0098735"(positive regulation of the force of heart contraction)|go:"GO:0098904"(regulation of AV node cell action potential)|go:"GO:0098907"(regulation of SA node cell action potential)|go:"GO:0098910"(regulation of atrial cardiac muscle cell action potential)|go:"GO:0098911"(regulation of ventricular cardiac muscle cell action potential)|go:"GO:1901896"(positive regulation of ATPase-coupled calcium transmembrane transporter activity)|interpro:IPR000699(Intracellular calcium-release channel)|interpro:IPR001870("B302 (SPRY)-like")|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR003032(Ryanodine receptor Ryr)|interpro:IPR003877(SPla/RYanodine receptor SPRY)|interpro:IPR005821(Ion transport)|interpro:IPR009460(Ryanodine Receptor TM 4-6)|interpro:IPR011992(EF-Hand type)|go:"GO:0005886"(plasma membrane)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0010460"(positive regulation of heart rate)|go:"GO:0010881"(regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014808"(release of sequestered calcium ion into cytosol by sarcoplasmic reticulum)|go:"GO:0014850"(response to muscle activity)|go:"GO:0015278"(calcium-release channel activity)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031000"(response to caffeine)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031672"(A band)|go:"GO:0032026"(response to magnesium ion)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033017"(sarcoplasmic reticulum membrane)|go:"GO:0034220"(ion transmembrane transport)|go:"GO:0034236"(protein kinase A catalytic subunit binding)|go:"GO:0034237"(protein kinase A regulatory subunit binding)|go:"GO:0034704"(calcium channel complex)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0035994"(response to muscle stretch)|go:"GO:0042383"(sarcolemma)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043621"(protein self-association)|go:"GO:0043924"(suramin binding)|go:"GO:0048763"(calcium-induced calcium release activity)|go:"GO:0051209"(release of sequestered calcium ion into cytosol)|go:"GO:0051284"(positive regulation of sequestering of calcium ion)|go:"GO:0051480"(regulation of cytosolic calcium ion concentration)|go:"GO:0051481"(negative regulation of cytosolic calcium ion concentration)|go:"GO:0051592"(response to calcium ion)|go:"GO:0051775"(response to redox state)|go:"GO:0055117"(regulation of cardiac muscle contraction)|go:"GO:0060048"(cardiac muscle contraction)|go:"GO:0060401"(cytosolic calcium ion transport)|go:"GO:0060402"(calcium ion transport into cytosol)|go:"GO:0070296"(sarcoplasmic reticulum calcium ion transport)|go:"GO:0070588"(calcium ion transmembrane transport)|go:"GO:0071313"(cellular response to caffeine)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|rcsb pdb:4ETV|rcsb pdb:4KEI|rcsb pdb:4KEJ|rcsb pdb:4KEK|rcsb pdb:4L4H|interpro:IPR013333(Ryanodine receptor, N-terminal)|rcsb pdb:4L4I|rcsb pdb:4P9I|interpro:IPR013662(RyR and IP3R Homology associated)|rcsb pdb:4P9L|interpro:IPR014821(Inositol 1,4,5-trisphosphate/ryanodine receptor)|rcsb pdb:5C33|rcsb pdb:5VSN|rcsb pdb:6J6L|rcsb pdb:6MM5|rcsb pdb:6MM6|rcsb pdb:6MM7|interpro:IPR016093(MIR motif)|rcsb pdb:6MM8|interpro:IPR035761|rcsb pdb:6WOU|rcsb pdb:6WOV|reactome:R-MMU-2672351|interpro:IPR035762|reactome:R-MMU-5578775|interpro:IPR035764|interpro:IPR035910|interpro:IPR036300|interpro:IPR043136|mint:E9Q401|rcsb pdb:2MC2|rcsb pdb:3IM5|rcsb pdb:3IM6|rcsb pdb:3IM7|rcsb pdb:3QR5|ensembl:ENSMUSG00000021313(gene)|ensembl:ENSMUST00000021750(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002027"(regulation of heart rate)|go:"GO:0003143"(embryonic heart tube morphogenesis)|go:"GO:0003220"(left ventricular cardiac muscle tissue morphogenesis)|go:"GO:0003300"(cardiac muscle hypertrophy)|go:"GO:0005219"(ryanodine-sensitive calcium-release channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005513"(detection of calcium ion)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005790"(smooth endoplasmic reticulum)	ensembl:ENSMUST00000095737(transcript)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005737"(cytoplasm)|go:"GO:0005901"(caveola)|go:"GO:0007194"(negative regulation of adenylate cyclase activity)|go:"GO:0008179"(adenylate cyclase binding)|go:"GO:0010738"(regulation of protein kinase A signaling)|go:"GO:0014701"(junctional sarcoplasmic reticulum membrane)|go:"GO:0014704"(intercalated disc)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0019899"(enzyme binding)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030315"(T-tubule)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034237"(protein kinase A regulatory subunit binding)|go:"GO:0034629"|go:"GO:0034704"(calcium channel complex)|go:"GO:0042383"(sarcolemma)|go:"GO:0043495"(protein-membrane adaptor activity)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051018"(protein kinase A binding)|go:"GO:0051281"(positive regulation of release of sequestered calcium ion into cytosol)|go:"GO:0051721"(protein phosphatase 2A binding)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0060306"(regulation of membrane repolarization)|go:"GO:0060316"(positive regulation of ryanodine-sensitive calcium-release channel activity)|go:"GO:0061051"(positive regulation of cell growth involved in cardiac muscle cell development)|go:"GO:0070886"(positive regulation of calcineurin-NFAT signaling cascade)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0071872"(cellular response to epinephrine stimulus)|go:"GO:0086004"(regulation of cardiac muscle cell contraction)|go:"GO:1901381"(positive regulation of potassium ion transmembrane transport)|go:"GO:1901897"(regulation of relaxation of cardiac muscle)|go:"GO:1902261"(positive regulation of delayed rectifier potassium channel activity)|go:"GO:2000481"(positive regulation of cAMP-dependent protein kinase activity)|interpro:IPR018159|interpro:IPR002017(Spectrin repeat)|refseq:XP_006515891.1|ensembl:ENSMUSG00000061603(gene)|refseq:NP_932779.2	-	-	-	figure legend:Fig. 3C, Supp. Fig. 2D|comment:Interaction reduced in PLCE-/- mice.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-heart)|taxid:10090(Mus musculus heart [Cardiac; Cardiac tissue])	-	2013/07/26	2015/05/20	rogid:HHxj8k5HJe0bbt0o041H0inQo0w10090	rogid:Lgqd30LMPt/TCef2Ywd7Txbv4PY10090	rigid:alKkNoN0A1dDpe3oqOjG9RrTuxU	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)