#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P06684	uniprotkb:P30993	intact:EBI-6879391|ensembl:ENSMUSP00000028233|uniprotkb:A2AS36	intact:EBI-6879364|uniprotkb:Q3TZ86|ensembl:ENSMUSP00000060003|ensembl:ENSMUSP00000129972	psi-mi:co5_mouse(display_long)|uniprotkb:C5(gene name)|psi-mi:C5(display_short)|uniprotkb:Hc(gene name synonym)|uniprotkb:Hemolytic complement(gene name synonym)	psi-mi:c5ar1_mouse(display_long)|uniprotkb:C5ar1(gene name)|psi-mi:C5ar1(display_short)|uniprotkb:C5ar(gene name synonym)|uniprotkb:C5r1(gene name synonym)|uniprotkb:C5a anaphylatoxin chemotactic receptor(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Strainic et al. (2013)	pubmed:23263555|imex:IM-21132	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0974"(InnateDB)	intact:EBI-6879362|imex:IM-21132-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000026874(gene)|ensembl:ENSMUST00000028233(transcript)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0004866"(endopeptidase inhibitor activity)|go:"GO:0005579"(membrane attack complex)|go:"GO:0005615"(extracellular space)|go:"GO:0006954"(inflammatory response)|go:"GO:0006957"(complement activation, alternative pathway)|go:"GO:0006958"(complement activation, classical pathway)|go:"GO:0010575"(positive regulation of vascular endothelial growth factor production)|go:"GO:0010760"(negative regulation of macrophage chemotaxis)|go:"GO:0019835"(cytolysis)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0045766"(positive regulation of angiogenesis)|interpro:IPR000020(Anaphylatoxin/fibulin)|interpro:IPR001134(Netrin, C-terminal)|interpro:IPR001599(Alpha-2-macroglobulin)|interpro:IPR002890(Alpha-2-macroglobulin, N-terminal)|interpro:IPR008930(Terpenoid cylases/protein prenyltransferase alpha-alpha toroid)|interpro:IPR008993(TIMP-like, OB-fold)|interpro:IPR009048(Alpha-macroglobulin, receptor-binding)|interpro:IPR011625(Alpha-2-macroglobulin, N-terminal 2)|interpro:IPR011626(A-macroglobulin complement component)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR018081|interpro:IPR018933|interpro:IPR036595|interpro:IPR037562|interpro:IPR040839|interpro:IPR041425|interpro:IPR041555|rcsb pdb:4P3A|rcsb pdb:4P3B|rcsb pdb:4WB2|rcsb pdb:4WB3|reactome:R-MMU-166665|reactome:R-MMU-174577|reactome:R-MMU-375276|reactome:R-MMU-418594|reactome:R-MMU-977606|refseq:NP_034536.2	refseq:NP_001167021.1|refseq:NP_031603.2|ensembl:ENSMUSG00000049130(gene)|ensembl:ENSMUST00000050770(transcript)|ensembl:ENSMUST00000168818(transcript)|go:"GO:0001774"(microglial cell activation)|go:"GO:0001856"(complement component C5a binding)|go:"GO:0002430"(complement receptor mediated signaling pathway)|go:"GO:0004875"(complement receptor activity)|go:"GO:0004878"(complement component C5a receptor activity)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0007200"(phospholipase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0009986"(cell surface)|go:"GO:0010575"(positive regulation of vascular endothelial growth factor production)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0021534"(cell proliferation in hindbrain)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032494"(response to peptidoglycan)|go:"GO:0038178"(complement component C5a signaling pathway)|go:"GO:0042789"(mRNA transcription by RNA polymerase II)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0045177"(apical part of cell)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0048143"(astrocyte activation)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0050890"(cognition)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0090023"(positive regulation of neutrophil chemotaxis)|go:"GO:0097242"(amyloid-beta clearance)|go:"GO:0099172"(presynapse organization)|go:"GO:1902947"(regulation of tau-protein kinase activity)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR000826(Formyl/methionyl peptide receptor)|interpro:IPR001274(C5A-anaphylatoxin receptor)|interpro:IPR002234(Anaphylatoxin chemotactic receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|reactome:R-MMU-375276|reactome:R-MMU-418594|reactome:R-MMU-6798695|reactome:R-MMU-977606	-	-	-	figure legend:Fig. 4H, S7C|comment:For sorted Foxp3-CD4+ T cells, the biotin-labeled C5a associated mainly with C5aR.|agonist:CD3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/07/04	2015/01/17	rogid:DJWB7iUX1s5YipRV64JIr8Mub7s10090	rogid:Oy/9nf36QXbmOJcoPSYX1FkFVyM10090	intact-crc:6B12A94BE40D83B4|rigid:qdUkG2C0mF09y1uNSorKpxAYtbE	false	his tag:n-n|biotin tag:?-?	-	-	-	psi-mi:"MI:0866"(tag visualisation)	psi-mi:"MI:0866"(tag visualisation)
uniprotkb:Q8BW93	uniprotkb:P06684	intact:EBI-6879440|ensembl:ENSMUSP00000133056|ensembl:ENSMUSP00000158951|uniprotkb:B2RQI1|uniprotkb:Q3TVM8	intact:EBI-6879391|ensembl:ENSMUSP00000028233|uniprotkb:A2AS36	psi-mi:c5ar2_mouse(display_long)|uniprotkb:C5ar2(gene name)|psi-mi:C5ar2(display_short)|uniprotkb:C5l2(gene name synonym)|uniprotkb:Gpr77(gene name synonym)|uniprotkb:Complement component 5a receptor 2(gene name synonym)|uniprotkb:G-protein coupled receptor 77(gene name synonym)	psi-mi:co5_mouse(display_long)|uniprotkb:C5(gene name)|psi-mi:C5(display_short)|uniprotkb:Hc(gene name synonym)|uniprotkb:Hemolytic complement(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Strainic et al. (2013)	pubmed:23263555|imex:IM-21132	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0974"(InnateDB)	intact:EBI-6879438|imex:IM-21132-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000074361(gene)|ensembl:ENSMUST00000171425(transcript)|ensembl:ENSMUST00000238927(transcript)|go:"GO:0002430"(complement receptor mediated signaling pathway)|go:"GO:0004875"(complement receptor activity)|go:"GO:0004878"(complement component C5a receptor activity)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007200"(phospholipase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0032677"(regulation of interleukin-8 production)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0045177"(apical part of cell)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0090024"(negative regulation of neutrophil chemotaxis)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR000826(Formyl/methionyl peptide receptor)|interpro:IPR001274(C5A-anaphylatoxin receptor)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|interpro:IPR027809|reactome:R-MMU-375276|reactome:R-MMU-977606|refseq:XP_006540115.1|refseq:XP_006540116.1|refseq:XP_006540117.1|refseq:XP_006540118.1|refseq:XP_006540119.1|refseq:XP_006540112.2|refseq:NP_001139477.1|refseq:NP_795886.2	ensembl:ENSMUSG00000026874(gene)|ensembl:ENSMUST00000028233(transcript)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0004866"(endopeptidase inhibitor activity)|go:"GO:0005579"(membrane attack complex)|go:"GO:0005615"(extracellular space)|go:"GO:0006954"(inflammatory response)|go:"GO:0006957"(complement activation, alternative pathway)|go:"GO:0006958"(complement activation, classical pathway)|go:"GO:0010575"(positive regulation of vascular endothelial growth factor production)|go:"GO:0010760"(negative regulation of macrophage chemotaxis)|go:"GO:0019835"(cytolysis)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0045766"(positive regulation of angiogenesis)|interpro:IPR000020(Anaphylatoxin/fibulin)|interpro:IPR001134(Netrin, C-terminal)|interpro:IPR001599(Alpha-2-macroglobulin)|interpro:IPR002890(Alpha-2-macroglobulin, N-terminal)|interpro:IPR008930(Terpenoid cylases/protein prenyltransferase alpha-alpha toroid)|interpro:IPR008993(TIMP-like, OB-fold)|interpro:IPR009048(Alpha-macroglobulin, receptor-binding)|interpro:IPR011625(Alpha-2-macroglobulin, N-terminal 2)|interpro:IPR011626(A-macroglobulin complement component)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR018081|interpro:IPR018933|interpro:IPR036595|interpro:IPR037562|interpro:IPR040839|interpro:IPR041425|interpro:IPR041555|rcsb pdb:4P3A|rcsb pdb:4P3B|rcsb pdb:4WB2|rcsb pdb:4WB3|reactome:R-MMU-166665|reactome:R-MMU-174577|reactome:R-MMU-375276|reactome:R-MMU-418594|reactome:R-MMU-977606|refseq:NP_034536.2	-	-	-	figure legend:Fig. 4H|comment:For sorted Foxp3+ iTreg cells, the biotin-labeled C5a associated mainly with C5L2.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/07/04	2014/10/16	rogid:oF7uepPh4CJdm05g+5mL0s8qwbM10090	rogid:DJWB7iUX1s5YipRV64JIr8Mub7s10090	intact-crc:6FD5A8D8ACC92A63|rigid:J1vcIBOSZGAW9t48JPgEdSrNKjs	false	-	biotin tag:?-?|his tag:n-n	-	-	psi-mi:"MI:0866"(tag visualisation)	psi-mi:"MI:0866"(tag visualisation)