#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q9QUK6	uniprotkb:Q8BJQ4	intact:EBI-1534575|uniprotkb:Q9D691|uniprotkb:Q9QZF5|uniprotkb:Q9Z203|ensembl:ENSMUSP00000045770	intact:EBI-6673819|ensembl:ENSMUSP00000066239|uniprotkb:Q3U996	psi-mi:tlr4_mouse(display_long)|uniprotkb:Tlr4(gene name)|psi-mi:Tlr4(display_short)|uniprotkb:Lps(gene name synonym)	psi-mi:tcam2_mouse(display_long)|uniprotkb:Ticam2(gene name)|psi-mi:Ticam2(display_short)|uniprotkb:Tirp(gene name synonym)|uniprotkb:Tram(gene name synonym)|uniprotkb:TRIF-related adapter molecule(gene name synonym)|uniprotkb:Toll/interleukin-1 receptor domain-containing protein(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Aksoy et al. (2012)	pubmed:23023391|imex:IM-20918	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0974"(InnateDB)	intact:EBI-6673841|imex:IM-20918-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067272.1|dip:DIP-38573N|ensembl:ENSMUSG00000039005(gene)|ensembl:ENSMUST00000048096(transcript)|go:"GO:0001530"(lipopolysaccharide binding)|go:"GO:0001726"(ruffle)|go:"GO:0001774"(microglial cell activation)|go:"GO:0001875"(lipopolysaccharide immune receptor activity)|go:"GO:0001891"(phagocytic cup)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0002224"(toll-like receptor signaling pathway)|go:"GO:0002322"(B cell proliferation involved in immune response)|go:"GO:0002537"(nitric oxide production involved in inflammatory response)|go:"GO:0002730"(regulation of dendritic cell cytokine production)|go:"GO:0002755"(MyD88-dependent toll-like receptor signaling pathway)|go:"GO:0002758"(innate immune response-activating signal transduction)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006691"(leukotriene metabolic process)|go:"GO:0006909"(phagocytosis)|go:"GO:0006954"(inflammatory response)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007250"(activation of NF-kappaB-inducing kinase activity)|go:"GO:0007252"(I-kappaB phosphorylation)|go:"GO:0009617"(response to bacterium)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010572"(positive regulation of platelet activation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0014002"(astrocyte development)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0031226"(intrinsic component of plasma membrane)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032497"(detection of lipopolysaccharide)|go:"GO:0032680"(regulation of tumor necrosis factor production)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032700"(negative regulation of interleukin-17 production)|go:"GO:0032707"(negative regulation of interleukin-23 production)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032732"(positive regulation of interleukin-1 production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032736"(positive regulation of interleukin-13 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032874"(positive regulation of stress-activated MAPK cascade)|go:"GO:0034142"(toll-like receptor 4 signaling pathway)|go:"GO:0035666"(TRIF-dependent toll-like receptor signaling pathway)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042116"(macrophage activation)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0042802"(identical protein binding)|go:"GO:0043032"(positive regulation of macrophage activation)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043235"(receptor complex)|go:"GO:0043388"(positive regulation of DNA binding)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045348"(positive regulation of MHC class II biosynthetic process)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0045471"(response to ethanol)|go:"GO:0045576"(mast cell activation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046696"(lipopolysaccharide receptor complex)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050135"("NAD(P)+ nucleosidase activity")|go:"GO:0050671"(positive regulation of lymphocyte proliferation)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0050965"(detection of temperature stimulus involved in sensory perception of pain)|go:"GO:0050966"(detection of mechanical stimulus involved in sensory perception of pain)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051770"(positive regulation of nitric-oxide synthase biosynthetic process)|go:"GO:0051930"(regulation of sensory perception of pain)|go:"GO:0060729"(intestinal epithelial structure maintenance)|go:"GO:0060907"(positive regulation of macrophage cytokine production)|go:"GO:0061809"(NAD+ nucleotidase, cyclic ADP-ribose generating)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070430"(positive regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway)|go:"GO:0070434"(positive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway)|go:"GO:0070542"(response to fatty acid)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071223"(cellular response to lipoteichoic acid)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|go:"GO:0140052"(cellular response to oxidised low-density lipoprotein particle stimulus)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|go:"GO:1900227"(positive regulation of NLRP3 inflammasome complex assembly)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1903223"(positive regulation of oxidative stress-induced neuron death)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1903974"(positive regulation of cellular response to macrophage colony-stimulating factor stimulus)|go:"GO:1904466"(positive regulation of matrix metallopeptidase secretion)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:2000343"("positive regulation of chemokine (C-X-C motif) ligand 2 production")|interpro:IPR000157(Toll-Interleukin receptor)|interpro:IPR000483(Cysteine-rich flanking region, C-terminal)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR017241(Toll-like receptor)|interpro:IPR032675|interpro:IPR035897|rcsb pdb:2Z64|rcsb pdb:3VQ1|rcsb pdb:3VQ2|rcsb pdb:5IJB|rcsb pdb:5IJC|rcsb pdb:5IJD|reactome:R-MMU-140534|reactome:R-MMU-166016|reactome:R-MMU-166166|reactome:R-MMU-2562578|reactome:R-MMU-5686938|reactome:R-MMU-936964|reactome:R-MMU-937041|reactome:R-MMU-937072|reactome:R-MMU-9707616|reactome:R-MMU-975163	go:"GO:0007030"(Golgi organization)|go:"GO:0030134"(COPII-coated ER to Golgi transport vesicle)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0034144"(negative regulation of toll-like receptor 4 signaling pathway)|go:"GO:0034145"(positive regulation of toll-like receptor 4 signaling pathway)|go:"GO:0035669"(TRAM-dependent toll-like receptor 4 signaling pathway)|go:"GO:0042995"(cell projection)|go:"GO:0006954"(inflammatory response)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045087"(innate immune response)|go:"GO:0045323"(interleukin-1 receptor complex)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051607"(defense response to virus)|go:"GO:0070671"(response to interleukin-12)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071650"("negative regulation of chemokine (C-C motif) ligand 5 production")|go:"GO:0071651"("positive regulation of chemokine (C-C motif) ligand 5 production")|go:"GO:2000494"(positive regulation of interleukin-18-mediated signaling pathway)|interpro:IPR000157(Toll-Interleukin receptor)|interpro:IPR015720(TMP21 related)|interpro:IPR035897|ensembl:ENSMUSG00000056130(gene)|ensembl:ENSMUST00000070084(transcript)|go:"GO:0001817"(regulation of cytokine production)|go:"GO:0001891"(phagocytic cup)|go:"GO:0005149"(interleukin-1 receptor binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0006909"(phagocytosis)|refseq:NP_775570.1	-	-	-	figure legend:Fig. 1F|agonist:LPS|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-bmdc)|taxid:10090(Mus musculus bone marrow-derived dendritic cells)	-	2013/05/15	2014/10/16	rogid:tVbu3ZsGm01Y4tO+vmeNtUXX7rc10090	rogid:+DGj94VYlYXCAXBzS0JAJFhpaPU10090	intact-crc:ED43CC603384038B|rigid:q76LAaSqwiN2osXQZ9ZEFuFH6eA	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9QUK6	uniprotkb:P22366	intact:EBI-1534575|uniprotkb:Q9D691|uniprotkb:Q9QZF5|uniprotkb:Q9Z203|ensembl:ENSMUSP00000045770	intact:EBI-525108|uniprotkb:O35916|ensembl:ENSMUSP00000035092	psi-mi:tlr4_mouse(display_long)|uniprotkb:Tlr4(gene name)|psi-mi:Tlr4(display_short)|uniprotkb:Lps(gene name synonym)	psi-mi:myd88_mouse(display_long)|uniprotkb:Myd88(gene name)|psi-mi:Myd88(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Aksoy et al. (2012)	pubmed:23023391|imex:IM-20918	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0974"(InnateDB)	intact:EBI-6673841|imex:IM-20918-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067272.1|dip:DIP-38573N|ensembl:ENSMUSG00000039005(gene)|ensembl:ENSMUST00000048096(transcript)|go:"GO:0001530"(lipopolysaccharide binding)|go:"GO:0001726"(ruffle)|go:"GO:0001774"(microglial cell activation)|go:"GO:0001875"(lipopolysaccharide immune receptor activity)|go:"GO:0001891"(phagocytic cup)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0002224"(toll-like receptor signaling pathway)|go:"GO:0002322"(B cell proliferation involved in immune response)|go:"GO:0002537"(nitric oxide production involved in inflammatory response)|go:"GO:0002730"(regulation of dendritic cell cytokine production)|go:"GO:0002755"(MyD88-dependent toll-like receptor signaling pathway)|go:"GO:0002758"(innate immune response-activating signal transduction)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006691"(leukotriene metabolic process)|go:"GO:0006909"(phagocytosis)|go:"GO:0006954"(inflammatory response)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007250"(activation of NF-kappaB-inducing kinase activity)|go:"GO:0007252"(I-kappaB phosphorylation)|go:"GO:0009617"(response to bacterium)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010572"(positive regulation of platelet activation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0014002"(astrocyte development)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0031226"(intrinsic component of plasma membrane)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032497"(detection of lipopolysaccharide)|go:"GO:0032680"(regulation of tumor necrosis factor production)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032700"(negative regulation of interleukin-17 production)|go:"GO:0032707"(negative regulation of interleukin-23 production)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032732"(positive regulation of interleukin-1 production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032736"(positive regulation of interleukin-13 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032874"(positive regulation of stress-activated MAPK cascade)|go:"GO:0034142"(toll-like receptor 4 signaling pathway)|go:"GO:0035666"(TRIF-dependent toll-like receptor signaling pathway)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042116"(macrophage activation)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0042802"(identical protein binding)|go:"GO:0043032"(positive regulation of macrophage activation)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043235"(receptor complex)|go:"GO:0043388"(positive regulation of DNA binding)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045348"(positive regulation of MHC class II biosynthetic process)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0045471"(response to ethanol)|go:"GO:0045576"(mast cell activation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046696"(lipopolysaccharide receptor complex)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050135"("NAD(P)+ nucleosidase activity")|go:"GO:0050671"(positive regulation of lymphocyte proliferation)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0050965"(detection of temperature stimulus involved in sensory perception of pain)|go:"GO:0050966"(detection of mechanical stimulus involved in sensory perception of pain)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051770"(positive regulation of nitric-oxide synthase biosynthetic process)|go:"GO:0051930"(regulation of sensory perception of pain)|go:"GO:0060729"(intestinal epithelial structure maintenance)|go:"GO:0060907"(positive regulation of macrophage cytokine production)|go:"GO:0061809"(NAD+ nucleotidase, cyclic ADP-ribose generating)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070430"(positive regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway)|go:"GO:0070434"(positive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway)|go:"GO:0070542"(response to fatty acid)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071223"(cellular response to lipoteichoic acid)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|go:"GO:0140052"(cellular response to oxidised low-density lipoprotein particle stimulus)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|go:"GO:1900227"(positive regulation of NLRP3 inflammasome complex assembly)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1903223"(positive regulation of oxidative stress-induced neuron death)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1903974"(positive regulation of cellular response to macrophage colony-stimulating factor stimulus)|go:"GO:1904466"(positive regulation of matrix metallopeptidase secretion)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:2000343"("positive regulation of chemokine (C-X-C motif) ligand 2 production")|interpro:IPR000157(Toll-Interleukin receptor)|interpro:IPR000483(Cysteine-rich flanking region, C-terminal)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR017241(Toll-like receptor)|interpro:IPR032675|interpro:IPR035897|rcsb pdb:2Z64|rcsb pdb:3VQ1|rcsb pdb:3VQ2|rcsb pdb:5IJB|rcsb pdb:5IJC|rcsb pdb:5IJD|reactome:R-MMU-140534|reactome:R-MMU-166016|reactome:R-MMU-166166|reactome:R-MMU-2562578|reactome:R-MMU-5686938|reactome:R-MMU-936964|reactome:R-MMU-937041|reactome:R-MMU-937072|reactome:R-MMU-9707616|reactome:R-MMU-975163	refseq:NP_034981.1|dip:DIP-34957N|ensembl:ENSMUSG00000032508(gene)|ensembl:ENSMUST00000035092(transcript)|go:"GO:0002238"(response to molecule of fungal origin)|go:"GO:0002269"(leukocyte activation involved in inflammatory response)|go:"GO:0002283"(neutrophil activation involved in immune response)|go:"GO:0002755"(MyD88-dependent toll-like receptor signaling pathway)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005121"(Toll binding)|go:"GO:0005149"(interleukin-1 receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006909"(phagocytosis)|go:"GO:0006915"(apoptotic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007178"(transmembrane receptor protein serine/threonine kinase signaling pathway)|go:"GO:0007254"(JNK cascade)|go:"GO:0008063"(Toll signaling pathway)|go:"GO:0009615"(response to virus)|go:"GO:0009682"(induced systemic resistance)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016064"(immunoglobulin mediated immune response)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032481"(positive regulation of type I interferon production)|go:"GO:0032494"(response to peptidoglycan)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032675"(regulation of interleukin-6 production)|go:"GO:0032680"(regulation of tumor necrosis factor production)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032740"(positive regulation of interleukin-17 production)|go:"GO:0032747"(positive regulation of interleukin-23 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034158"(toll-like receptor 8 signaling pathway)|go:"GO:0035325"(Toll-like receptor binding)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0042802"(identical protein binding)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043621"(protein self-association)|go:"GO:0045087"(innate immune response)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050671"(positive regulation of lymphocyte proliferation)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051607"(defense response to virus)|go:"GO:0060337"(type I interferon signaling pathway)|go:"GO:0070498"(interleukin-1-mediated signaling pathway)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070935"(3'-UTR-mediated mRNA stabilization)|go:"GO:0070944"(neutrophil-mediated killing of bacterium)|go:"GO:0070976"(TIR domain binding)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0090557"(establishment of endothelial intestinal barrier)|go:"GO:0140052"(cellular response to oxidised low-density lipoprotein particle stimulus)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|go:"GO:1900227"(positive regulation of NLRP3 inflammasome complex assembly)|go:"GO:1902622"(regulation of neutrophil migration)|go:"GO:2000338"("regulation of chemokine (C-X-C motif) ligand 1 production")|go:"GO:2000341"("regulation of chemokine (C-X-C motif) ligand 2 production")|interpro:IPR000157(Toll-Interleukin receptor)|interpro:IPR000488(Death)|interpro:IPR011029(DEATH-like)|interpro:IPR017281(Myeloid differentiation primary response protein MyD88)|interpro:IPR034249|interpro:IPR035897|mint:P22366|go:"GO:0042832"(defense response to protozoan)|reactome:R-MMU-1810476|reactome:R-MMU-209543|reactome:R-MMU-3134963|reactome:R-MMU-6811558|reactome:R-MMU-9020702|reactome:R-MMU-1257604	-	-	-	figure legend:Fig. 1F|agonist:LPS|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-bmdc)|taxid:10090(Mus musculus bone marrow-derived dendritic cells)	-	2013/05/15	2014/10/16	rogid:tVbu3ZsGm01Y4tO+vmeNtUXX7rc10090	rogid:4bHizxwWAnvXGR+Uos99jAL3iDU10090	intact-crc:ED43CC603384038B|rigid:q76LAaSqwiN2osXQZ9ZEFuFH6eA	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9QUK6	uniprotkb:O35904	intact:EBI-1534575|uniprotkb:Q9D691|uniprotkb:Q9QZF5|uniprotkb:Q9Z203|ensembl:ENSMUSP00000045770	intact:EBI-647932|uniprotkb:Q8CJ28|ensembl:ENSMUSP00000101314	psi-mi:tlr4_mouse(display_long)|uniprotkb:Tlr4(gene name)|psi-mi:Tlr4(display_short)|uniprotkb:Lps(gene name synonym)	psi-mi:pk3cd_mouse(display_long)|uniprotkb:Pik3cd(gene name)|psi-mi:Pik3cd(display_short)|uniprotkb:Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit delta(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Aksoy et al. (2012)	pubmed:23023391|imex:IM-20918	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0974"(InnateDB)	intact:EBI-6673841|imex:IM-20918-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067272.1|dip:DIP-38573N|ensembl:ENSMUSG00000039005(gene)|ensembl:ENSMUST00000048096(transcript)|go:"GO:0001530"(lipopolysaccharide binding)|go:"GO:0001726"(ruffle)|go:"GO:0001774"(microglial cell activation)|go:"GO:0001875"(lipopolysaccharide immune receptor activity)|go:"GO:0001891"(phagocytic cup)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0002224"(toll-like receptor signaling pathway)|go:"GO:0002322"(B cell proliferation involved in immune response)|go:"GO:0002537"(nitric oxide production involved in inflammatory response)|go:"GO:0002730"(regulation of dendritic cell cytokine production)|go:"GO:0002755"(MyD88-dependent toll-like receptor signaling pathway)|go:"GO:0002758"(innate immune response-activating signal transduction)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006691"(leukotriene metabolic process)|go:"GO:0006909"(phagocytosis)|go:"GO:0006954"(inflammatory response)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007250"(activation of NF-kappaB-inducing kinase activity)|go:"GO:0007252"(I-kappaB phosphorylation)|go:"GO:0009617"(response to bacterium)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010572"(positive regulation of platelet activation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0014002"(astrocyte development)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0031226"(intrinsic component of plasma membrane)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032497"(detection of lipopolysaccharide)|go:"GO:0032680"(regulation of tumor necrosis factor production)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032700"(negative regulation of interleukin-17 production)|go:"GO:0032707"(negative regulation of interleukin-23 production)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032732"(positive regulation of interleukin-1 production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032736"(positive regulation of interleukin-13 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032874"(positive regulation of stress-activated MAPK cascade)|go:"GO:0034142"(toll-like receptor 4 signaling pathway)|go:"GO:0035666"(TRIF-dependent toll-like receptor signaling pathway)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042116"(macrophage activation)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0042802"(identical protein binding)|go:"GO:0043032"(positive regulation of macrophage activation)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043235"(receptor complex)|go:"GO:0043388"(positive regulation of DNA binding)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045348"(positive regulation of MHC class II biosynthetic process)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0045471"(response to ethanol)|go:"GO:0045576"(mast cell activation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046696"(lipopolysaccharide receptor complex)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050135"("NAD(P)+ nucleosidase activity")|go:"GO:0050671"(positive regulation of lymphocyte proliferation)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0050965"(detection of temperature stimulus involved in sensory perception of pain)|go:"GO:0050966"(detection of mechanical stimulus involved in sensory perception of pain)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051770"(positive regulation of nitric-oxide synthase biosynthetic process)|go:"GO:0051930"(regulation of sensory perception of pain)|go:"GO:0060729"(intestinal epithelial structure maintenance)|go:"GO:0060907"(positive regulation of macrophage cytokine production)|go:"GO:0061809"(NAD+ nucleotidase, cyclic ADP-ribose generating)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070430"(positive regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway)|go:"GO:0070434"(positive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway)|go:"GO:0070542"(response to fatty acid)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071223"(cellular response to lipoteichoic acid)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|go:"GO:0140052"(cellular response to oxidised low-density lipoprotein particle stimulus)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|go:"GO:1900227"(positive regulation of NLRP3 inflammasome complex assembly)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1903223"(positive regulation of oxidative stress-induced neuron death)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1903974"(positive regulation of cellular response to macrophage colony-stimulating factor stimulus)|go:"GO:1904466"(positive regulation of matrix metallopeptidase secretion)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:2000343"("positive regulation of chemokine (C-X-C motif) ligand 2 production")|interpro:IPR000157(Toll-Interleukin receptor)|interpro:IPR000483(Cysteine-rich flanking region, C-terminal)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR017241(Toll-like receptor)|interpro:IPR032675|interpro:IPR035897|rcsb pdb:2Z64|rcsb pdb:3VQ1|rcsb pdb:3VQ2|rcsb pdb:5IJB|rcsb pdb:5IJC|rcsb pdb:5IJD|reactome:R-MMU-140534|reactome:R-MMU-166016|reactome:R-MMU-166166|reactome:R-MMU-2562578|reactome:R-MMU-5686938|reactome:R-MMU-936964|reactome:R-MMU-937041|reactome:R-MMU-937072|reactome:R-MMU-9707616|reactome:R-MMU-975163	refseq:NP_001157524.1|refseq:XP_006538715.1|dip:DIP-39841N|ensembl:ENSMUSG00000039936(gene)|ensembl:ENSMUST00000105689(transcript)|go:"GO:0001782"(B cell homeostasis)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0016020"(membrane)|go:"GO:0016301"(kinase activity)|go:"GO:0016303"(1-phosphatidylinositol-3-kinase activity)|go:"GO:0016310"(phosphorylation)|go:"GO:0016477"(cell migration)|go:"GO:0030154"(cell differentiation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0033031"(positive regulation of neutrophil apoptotic process)|go:"GO:0035005"(1-phosphatidylinositol-4-phosphate 3-kinase activity)|go:"GO:0036092"(phosphatidylinositol-3-phosphate biosynthetic process)|go:"GO:0038089"(positive regulation of cell migration by vascular endothelial growth factor signaling pathway)|go:"GO:0042113"(B cell activation)|go:"GO:0045087"(innate immune response)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0046934"(phosphatidylinositol-4,5-bisphosphate 3-kinase activity)|go:"GO:0048015"(phosphatidylinositol-mediated signaling)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0050832"(defense response to fungus)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0052742"(phosphatidylinositol kinase activity)|go:"GO:0052812"(phosphatidylinositol-3,4-bisphosphate 5-kinase activity)|go:"GO:1905278"(positive regulation of epithelial tube formation)|interpro:IPR000341(Phosphoinositide 3-kinase, ras-binding)|interpro:IPR000403(Phosphatidylinositol 3- and 4-kinase, catalytic)|interpro:IPR001263(Phosphoinositide 3-kinase accessory region PIK)|interpro:IPR002420(Phosphoinositide 3-kinase, C2)|interpro:IPR003113(Phosphatidylinositol 3-kinase, p85-binding)|interpro:IPR011009(Protein kinase-like)|interpro:IPR015433(Phosphatidylinositol Kinase)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR018936|interpro:IPR029071|interpro:IPR035892|interpro:IPR036940|interpro:IPR037703|interpro:IPR042236|rcsb pdb:2WXF|rcsb pdb:2WXG|rcsb pdb:2WXH|rcsb pdb:2WXI|rcsb pdb:2WXJ|rcsb pdb:2WXK|rcsb pdb:2WXL|rcsb pdb:2WXM|rcsb pdb:2WXN|rcsb pdb:2WXO|rcsb pdb:2WXP|rcsb pdb:2WXQ|rcsb pdb:2WXR|rcsb pdb:2X38|rcsb pdb:4AJW|rcsb pdb:4V0I|rcsb pdb:4XE0|rcsb pdb:5AE8|rcsb pdb:5AE9|rcsb pdb:5I4U|rcsb pdb:5I6U|rcsb pdb:5IS5|rcsb pdb:5L72|rcsb pdb:5NCY|rcsb pdb:5NCZ|rcsb pdb:5NGB|rcsb pdb:5O83|rcsb pdb:5T27|rcsb pdb:5T28|rcsb pdb:5T2B|rcsb pdb:5T2D|rcsb pdb:5T2G|rcsb pdb:5T2I|rcsb pdb:5T2L|rcsb pdb:5T2M|rcsb pdb:5T7F|rcsb pdb:5T8I|rcsb pdb:6DGT|rcsb pdb:6EYZ|rcsb pdb:6EZ6|rcsb pdb:6GY0|rcsb pdb:6HI9|rcsb pdb:6MUL|rcsb pdb:6MUM|reactome:R-MMU-1257604|reactome:R-MMU-1660499|reactome:R-MMU-512988|reactome:R-MMU-6811558|reactome:R-MMU-8853659|reactome:R-MMU-9027276|reactome:R-MMU-912526|reactome:R-MMU-912631|reactome:R-MMU-983695	-	-	-	figure legend:Fig. 1F|agonist:LPS|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-bmdc)|taxid:10090(Mus musculus bone marrow-derived dendritic cells)	-	2013/05/15	2014/10/16	rogid:tVbu3ZsGm01Y4tO+vmeNtUXX7rc10090	rogid:mcGmhHve+Mi2DhcQ7akqBFC0OfI10090	intact-crc:ED43CC603384038B|rigid:q76LAaSqwiN2osXQZ9ZEFuFH6eA	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:O35904	uniprotkb:Q9QUK6	intact:EBI-647932|uniprotkb:Q8CJ28|ensembl:ENSMUSP00000101314	intact:EBI-1534575|uniprotkb:Q9D691|uniprotkb:Q9QZF5|uniprotkb:Q9Z203|ensembl:ENSMUSP00000045770	psi-mi:pk3cd_mouse(display_long)|uniprotkb:Pik3cd(gene name)|psi-mi:Pik3cd(display_short)|uniprotkb:Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit delta(gene name synonym)	psi-mi:tlr4_mouse(display_long)|uniprotkb:Tlr4(gene name)|psi-mi:Tlr4(display_short)|uniprotkb:Lps(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Aksoy et al. (2012)	pubmed:23023391|imex:IM-20918	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0974"(InnateDB)	intact:EBI-6673856|imex:IM-20918-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001157524.1|refseq:XP_006538715.1|dip:DIP-39841N|ensembl:ENSMUSG00000039936(gene)|ensembl:ENSMUST00000105689(transcript)|go:"GO:0001782"(B cell homeostasis)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0016020"(membrane)|go:"GO:0016301"(kinase activity)|go:"GO:0016303"(1-phosphatidylinositol-3-kinase activity)|go:"GO:0016310"(phosphorylation)|go:"GO:0016477"(cell migration)|go:"GO:0030154"(cell differentiation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0033031"(positive regulation of neutrophil apoptotic process)|go:"GO:0035005"(1-phosphatidylinositol-4-phosphate 3-kinase activity)|go:"GO:0036092"(phosphatidylinositol-3-phosphate biosynthetic process)|go:"GO:0038089"(positive regulation of cell migration by vascular endothelial growth factor signaling pathway)|go:"GO:0042113"(B cell activation)|go:"GO:0045087"(innate immune response)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0046934"(phosphatidylinositol-4,5-bisphosphate 3-kinase activity)|go:"GO:0048015"(phosphatidylinositol-mediated signaling)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0050832"(defense response to fungus)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0052742"(phosphatidylinositol kinase activity)|go:"GO:0052812"(phosphatidylinositol-3,4-bisphosphate 5-kinase activity)|go:"GO:1905278"(positive regulation of epithelial tube formation)|interpro:IPR000341(Phosphoinositide 3-kinase, ras-binding)|interpro:IPR000403(Phosphatidylinositol 3- and 4-kinase, catalytic)|interpro:IPR001263(Phosphoinositide 3-kinase accessory region PIK)|interpro:IPR002420(Phosphoinositide 3-kinase, C2)|interpro:IPR003113(Phosphatidylinositol 3-kinase, p85-binding)|interpro:IPR011009(Protein kinase-like)|interpro:IPR015433(Phosphatidylinositol Kinase)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR018936|interpro:IPR029071|interpro:IPR035892|interpro:IPR036940|interpro:IPR037703|interpro:IPR042236|rcsb pdb:2WXF|rcsb pdb:2WXG|rcsb pdb:2WXH|rcsb pdb:2WXI|rcsb pdb:2WXJ|rcsb pdb:2WXK|rcsb pdb:2WXL|rcsb pdb:2WXM|rcsb pdb:2WXN|rcsb pdb:2WXO|rcsb pdb:2WXP|rcsb pdb:2WXQ|rcsb pdb:2WXR|rcsb pdb:2X38|rcsb pdb:4AJW|rcsb pdb:4V0I|rcsb pdb:4XE0|rcsb pdb:5AE8|rcsb pdb:5AE9|rcsb pdb:5I4U|rcsb pdb:5I6U|rcsb pdb:5IS5|rcsb pdb:5L72|rcsb pdb:5NCY|rcsb pdb:5NCZ|rcsb pdb:5NGB|rcsb pdb:5O83|rcsb pdb:5T27|rcsb pdb:5T28|rcsb pdb:5T2B|rcsb pdb:5T2D|rcsb pdb:5T2G|rcsb pdb:5T2I|rcsb pdb:5T2L|rcsb pdb:5T2M|rcsb pdb:5T7F|rcsb pdb:5T8I|rcsb pdb:6DGT|rcsb pdb:6EYZ|rcsb pdb:6EZ6|rcsb pdb:6GY0|rcsb pdb:6HI9|rcsb pdb:6MUL|rcsb pdb:6MUM|reactome:R-MMU-1257604|reactome:R-MMU-1660499|reactome:R-MMU-512988|reactome:R-MMU-6811558|reactome:R-MMU-8853659|reactome:R-MMU-9027276|reactome:R-MMU-912526|reactome:R-MMU-912631|reactome:R-MMU-983695	refseq:NP_067272.1|dip:DIP-38573N|ensembl:ENSMUSG00000039005(gene)|ensembl:ENSMUST00000048096(transcript)|go:"GO:0001530"(lipopolysaccharide binding)|go:"GO:0001726"(ruffle)|go:"GO:0001774"(microglial cell activation)|go:"GO:0001875"(lipopolysaccharide immune receptor activity)|go:"GO:0001891"(phagocytic cup)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0002224"(toll-like receptor signaling pathway)|go:"GO:0002322"(B cell proliferation involved in immune response)|go:"GO:0002537"(nitric oxide production involved in inflammatory response)|go:"GO:0002730"(regulation of dendritic cell cytokine production)|go:"GO:0002755"(MyD88-dependent toll-like receptor signaling pathway)|go:"GO:0002758"(innate immune response-activating signal transduction)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006691"(leukotriene metabolic process)|go:"GO:0006909"(phagocytosis)|go:"GO:0006954"(inflammatory response)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007250"(activation of NF-kappaB-inducing kinase activity)|go:"GO:0007252"(I-kappaB phosphorylation)|go:"GO:0009617"(response to bacterium)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010572"(positive regulation of platelet activation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0014002"(astrocyte development)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0031226"(intrinsic component of plasma membrane)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032497"(detection of lipopolysaccharide)|go:"GO:0032680"(regulation of tumor necrosis factor production)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032700"(negative regulation of interleukin-17 production)|go:"GO:0032707"(negative regulation of interleukin-23 production)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032732"(positive regulation of interleukin-1 production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032736"(positive regulation of interleukin-13 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032874"(positive regulation of stress-activated MAPK cascade)|go:"GO:0034142"(toll-like receptor 4 signaling pathway)|go:"GO:0035666"(TRIF-dependent toll-like receptor signaling pathway)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042116"(macrophage activation)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0042802"(identical protein binding)|go:"GO:0043032"(positive regulation of macrophage activation)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043235"(receptor complex)|go:"GO:0043388"(positive regulation of DNA binding)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045348"(positive regulation of MHC class II biosynthetic process)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0045471"(response to ethanol)|go:"GO:0045576"(mast cell activation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046696"(lipopolysaccharide receptor complex)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050135"("NAD(P)+ nucleosidase activity")|go:"GO:0050671"(positive regulation of lymphocyte proliferation)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0050965"(detection of temperature stimulus involved in sensory perception of pain)|go:"GO:0050966"(detection of mechanical stimulus involved in sensory perception of pain)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051770"(positive regulation of nitric-oxide synthase biosynthetic process)|go:"GO:0051930"(regulation of sensory perception of pain)|go:"GO:0060729"(intestinal epithelial structure maintenance)|go:"GO:0060907"(positive regulation of macrophage cytokine production)|go:"GO:0061809"(NAD+ nucleotidase, cyclic ADP-ribose generating)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070430"(positive regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway)|go:"GO:0070434"(positive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway)|go:"GO:0070542"(response to fatty acid)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071223"(cellular response to lipoteichoic acid)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|go:"GO:0140052"(cellular response to oxidised low-density lipoprotein particle stimulus)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|go:"GO:1900227"(positive regulation of NLRP3 inflammasome complex assembly)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1903223"(positive regulation of oxidative stress-induced neuron death)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1903974"(positive regulation of cellular response to macrophage colony-stimulating factor stimulus)|go:"GO:1904466"(positive regulation of matrix metallopeptidase secretion)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:2000343"("positive regulation of chemokine (C-X-C motif) ligand 2 production")|interpro:IPR000157(Toll-Interleukin receptor)|interpro:IPR000483(Cysteine-rich flanking region, C-terminal)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR017241(Toll-like receptor)|interpro:IPR032675|interpro:IPR035897|rcsb pdb:2Z64|rcsb pdb:3VQ1|rcsb pdb:3VQ2|rcsb pdb:5IJB|rcsb pdb:5IJC|rcsb pdb:5IJD|reactome:R-MMU-140534|reactome:R-MMU-166016|reactome:R-MMU-166166|reactome:R-MMU-2562578|reactome:R-MMU-5686938|reactome:R-MMU-936964|reactome:R-MMU-937041|reactome:R-MMU-937072|reactome:R-MMU-9707616|reactome:R-MMU-975163	-	-	-	figure legend:Fig. 1G|agonist:LPS|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-bmdc)|taxid:10090(Mus musculus bone marrow-derived dendritic cells)	-	2013/05/15	2014/10/16	rogid:mcGmhHve+Mi2DhcQ7akqBFC0OfI10090	rogid:tVbu3ZsGm01Y4tO+vmeNtUXX7rc10090	intact-crc:B6F5AAA5A6D3CD7D|rigid:AYXkU7Q8EL+7L4wU2fEccGUloUY	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:O35904	uniprotkb:P22366	intact:EBI-647932|uniprotkb:Q8CJ28|ensembl:ENSMUSP00000101314	intact:EBI-525108|uniprotkb:O35916|ensembl:ENSMUSP00000035092	psi-mi:pk3cd_mouse(display_long)|uniprotkb:Pik3cd(gene name)|psi-mi:Pik3cd(display_short)|uniprotkb:Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit delta(gene name synonym)	psi-mi:myd88_mouse(display_long)|uniprotkb:Myd88(gene name)|psi-mi:Myd88(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Aksoy et al. (2012)	pubmed:23023391|imex:IM-20918	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0974"(InnateDB)	intact:EBI-6673856|imex:IM-20918-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001157524.1|refseq:XP_006538715.1|dip:DIP-39841N|ensembl:ENSMUSG00000039936(gene)|ensembl:ENSMUST00000105689(transcript)|go:"GO:0001782"(B cell homeostasis)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0016020"(membrane)|go:"GO:0016301"(kinase activity)|go:"GO:0016303"(1-phosphatidylinositol-3-kinase activity)|go:"GO:0016310"(phosphorylation)|go:"GO:0016477"(cell migration)|go:"GO:0030154"(cell differentiation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0033031"(positive regulation of neutrophil apoptotic process)|go:"GO:0035005"(1-phosphatidylinositol-4-phosphate 3-kinase activity)|go:"GO:0036092"(phosphatidylinositol-3-phosphate biosynthetic process)|go:"GO:0038089"(positive regulation of cell migration by vascular endothelial growth factor signaling pathway)|go:"GO:0042113"(B cell activation)|go:"GO:0045087"(innate immune response)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0046934"(phosphatidylinositol-4,5-bisphosphate 3-kinase activity)|go:"GO:0048015"(phosphatidylinositol-mediated signaling)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0050832"(defense response to fungus)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0052742"(phosphatidylinositol kinase activity)|go:"GO:0052812"(phosphatidylinositol-3,4-bisphosphate 5-kinase activity)|go:"GO:1905278"(positive regulation of epithelial tube formation)|interpro:IPR000341(Phosphoinositide 3-kinase, ras-binding)|interpro:IPR000403(Phosphatidylinositol 3- and 4-kinase, catalytic)|interpro:IPR001263(Phosphoinositide 3-kinase accessory region PIK)|interpro:IPR002420(Phosphoinositide 3-kinase, C2)|interpro:IPR003113(Phosphatidylinositol 3-kinase, p85-binding)|interpro:IPR011009(Protein kinase-like)|interpro:IPR015433(Phosphatidylinositol Kinase)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR018936|interpro:IPR029071|interpro:IPR035892|interpro:IPR036940|interpro:IPR037703|interpro:IPR042236|rcsb pdb:2WXF|rcsb pdb:2WXG|rcsb pdb:2WXH|rcsb pdb:2WXI|rcsb pdb:2WXJ|rcsb pdb:2WXK|rcsb pdb:2WXL|rcsb pdb:2WXM|rcsb pdb:2WXN|rcsb pdb:2WXO|rcsb pdb:2WXP|rcsb pdb:2WXQ|rcsb pdb:2WXR|rcsb pdb:2X38|rcsb pdb:4AJW|rcsb pdb:4V0I|rcsb pdb:4XE0|rcsb pdb:5AE8|rcsb pdb:5AE9|rcsb pdb:5I4U|rcsb pdb:5I6U|rcsb pdb:5IS5|rcsb pdb:5L72|rcsb pdb:5NCY|rcsb pdb:5NCZ|rcsb pdb:5NGB|rcsb pdb:5O83|rcsb pdb:5T27|rcsb pdb:5T28|rcsb pdb:5T2B|rcsb pdb:5T2D|rcsb pdb:5T2G|rcsb pdb:5T2I|rcsb pdb:5T2L|rcsb pdb:5T2M|rcsb pdb:5T7F|rcsb pdb:5T8I|rcsb pdb:6DGT|rcsb pdb:6EYZ|rcsb pdb:6EZ6|rcsb pdb:6GY0|rcsb pdb:6HI9|rcsb pdb:6MUL|rcsb pdb:6MUM|reactome:R-MMU-1257604|reactome:R-MMU-1660499|reactome:R-MMU-512988|reactome:R-MMU-6811558|reactome:R-MMU-8853659|reactome:R-MMU-9027276|reactome:R-MMU-912526|reactome:R-MMU-912631|reactome:R-MMU-983695	refseq:NP_034981.1|dip:DIP-34957N|ensembl:ENSMUSG00000032508(gene)|ensembl:ENSMUST00000035092(transcript)|go:"GO:0002238"(response to molecule of fungal origin)|go:"GO:0002269"(leukocyte activation involved in inflammatory response)|go:"GO:0002283"(neutrophil activation involved in immune response)|go:"GO:0002755"(MyD88-dependent toll-like receptor signaling pathway)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005121"(Toll binding)|go:"GO:0005149"(interleukin-1 receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006909"(phagocytosis)|go:"GO:0006915"(apoptotic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007178"(transmembrane receptor protein serine/threonine kinase signaling pathway)|go:"GO:0007254"(JNK cascade)|go:"GO:0008063"(Toll signaling pathway)|go:"GO:0009615"(response to virus)|go:"GO:0009682"(induced systemic resistance)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016064"(immunoglobulin mediated immune response)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032481"(positive regulation of type I interferon production)|go:"GO:0032494"(response to peptidoglycan)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032675"(regulation of interleukin-6 production)|go:"GO:0032680"(regulation of tumor necrosis factor production)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032740"(positive regulation of interleukin-17 production)|go:"GO:0032747"(positive regulation of interleukin-23 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034158"(toll-like receptor 8 signaling pathway)|go:"GO:0035325"(Toll-like receptor binding)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0042802"(identical protein binding)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043621"(protein self-association)|go:"GO:0045087"(innate immune response)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050671"(positive regulation of lymphocyte proliferation)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051607"(defense response to virus)|go:"GO:0060337"(type I interferon signaling pathway)|go:"GO:0070498"(interleukin-1-mediated signaling pathway)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070935"(3'-UTR-mediated mRNA stabilization)|go:"GO:0070944"(neutrophil-mediated killing of bacterium)|go:"GO:0070976"(TIR domain binding)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0090557"(establishment of endothelial intestinal barrier)|go:"GO:0140052"(cellular response to oxidised low-density lipoprotein particle stimulus)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|go:"GO:1900227"(positive regulation of NLRP3 inflammasome complex assembly)|go:"GO:1902622"(regulation of neutrophil migration)|go:"GO:2000338"("regulation of chemokine (C-X-C motif) ligand 1 production")|go:"GO:2000341"("regulation of chemokine (C-X-C motif) ligand 2 production")|interpro:IPR000157(Toll-Interleukin receptor)|interpro:IPR000488(Death)|interpro:IPR011029(DEATH-like)|interpro:IPR017281(Myeloid differentiation primary response protein MyD88)|interpro:IPR034249|interpro:IPR035897|mint:P22366|go:"GO:0042832"(defense response to protozoan)|reactome:R-MMU-1810476|reactome:R-MMU-209543|reactome:R-MMU-3134963|reactome:R-MMU-6811558|reactome:R-MMU-9020702|reactome:R-MMU-1257604	-	-	-	figure legend:Fig. 1G|agonist:LPS|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-bmdc)|taxid:10090(Mus musculus bone marrow-derived dendritic cells)	-	2013/05/15	2014/10/16	rogid:mcGmhHve+Mi2DhcQ7akqBFC0OfI10090	rogid:4bHizxwWAnvXGR+Uos99jAL3iDU10090	intact-crc:B6F5AAA5A6D3CD7D|rigid:AYXkU7Q8EL+7L4wU2fEccGUloUY	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:O35904	uniprotkb:Q99JY1	intact:EBI-647932|uniprotkb:Q8CJ28|ensembl:ENSMUSP00000101314	intact:EBI-6559589|uniprotkb:Q91ZW0	psi-mi:pk3cd_mouse(display_long)|uniprotkb:Pik3cd(gene name)|psi-mi:Pik3cd(display_short)|uniprotkb:Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit delta(gene name synonym)	psi-mi:tirap_mouse(display_long)|uniprotkb:Tirap(gene name)|psi-mi:Tirap(display_short)|uniprotkb:Mal(gene name synonym)|uniprotkb:Adaptor protein Wyatt(gene name synonym)|uniprotkb:MyD88 adapter-like protein(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Aksoy et al. (2012)	pubmed:23023391|imex:IM-20918	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0974"(InnateDB)	intact:EBI-6673856|imex:IM-20918-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001157524.1|refseq:XP_006538715.1|dip:DIP-39841N|ensembl:ENSMUSG00000039936(gene)|ensembl:ENSMUST00000105689(transcript)|go:"GO:0001782"(B cell homeostasis)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0016020"(membrane)|go:"GO:0016301"(kinase activity)|go:"GO:0016303"(1-phosphatidylinositol-3-kinase activity)|go:"GO:0016310"(phosphorylation)|go:"GO:0016477"(cell migration)|go:"GO:0030154"(cell differentiation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0033031"(positive regulation of neutrophil apoptotic process)|go:"GO:0035005"(1-phosphatidylinositol-4-phosphate 3-kinase activity)|go:"GO:0036092"(phosphatidylinositol-3-phosphate biosynthetic process)|go:"GO:0038089"(positive regulation of cell migration by vascular endothelial growth factor signaling pathway)|go:"GO:0042113"(B cell activation)|go:"GO:0045087"(innate immune response)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0046934"(phosphatidylinositol-4,5-bisphosphate 3-kinase activity)|go:"GO:0048015"(phosphatidylinositol-mediated signaling)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0050832"(defense response to fungus)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0052742"(phosphatidylinositol kinase activity)|go:"GO:0052812"(phosphatidylinositol-3,4-bisphosphate 5-kinase activity)|go:"GO:1905278"(positive regulation of epithelial tube formation)|interpro:IPR000341(Phosphoinositide 3-kinase, ras-binding)|interpro:IPR000403(Phosphatidylinositol 3- and 4-kinase, catalytic)|interpro:IPR001263(Phosphoinositide 3-kinase accessory region PIK)|interpro:IPR002420(Phosphoinositide 3-kinase, C2)|interpro:IPR003113(Phosphatidylinositol 3-kinase, p85-binding)|interpro:IPR011009(Protein kinase-like)|interpro:IPR015433(Phosphatidylinositol Kinase)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR018936|interpro:IPR029071|interpro:IPR035892|interpro:IPR036940|interpro:IPR037703|interpro:IPR042236|rcsb pdb:2WXF|rcsb pdb:2WXG|rcsb pdb:2WXH|rcsb pdb:2WXI|rcsb pdb:2WXJ|rcsb pdb:2WXK|rcsb pdb:2WXL|rcsb pdb:2WXM|rcsb pdb:2WXN|rcsb pdb:2WXO|rcsb pdb:2WXP|rcsb pdb:2WXQ|rcsb pdb:2WXR|rcsb pdb:2X38|rcsb pdb:4AJW|rcsb pdb:4V0I|rcsb pdb:4XE0|rcsb pdb:5AE8|rcsb pdb:5AE9|rcsb pdb:5I4U|rcsb pdb:5I6U|rcsb pdb:5IS5|rcsb pdb:5L72|rcsb pdb:5NCY|rcsb pdb:5NCZ|rcsb pdb:5NGB|rcsb pdb:5O83|rcsb pdb:5T27|rcsb pdb:5T28|rcsb pdb:5T2B|rcsb pdb:5T2D|rcsb pdb:5T2G|rcsb pdb:5T2I|rcsb pdb:5T2L|rcsb pdb:5T2M|rcsb pdb:5T7F|rcsb pdb:5T8I|rcsb pdb:6DGT|rcsb pdb:6EYZ|rcsb pdb:6EZ6|rcsb pdb:6GY0|rcsb pdb:6HI9|rcsb pdb:6MUL|rcsb pdb:6MUM|reactome:R-MMU-1257604|reactome:R-MMU-1660499|reactome:R-MMU-512988|reactome:R-MMU-6811558|reactome:R-MMU-8853659|reactome:R-MMU-9027276|reactome:R-MMU-912526|reactome:R-MMU-912631|reactome:R-MMU-983695	go:"GO:0005080"(protein kinase C binding)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0007250"(activation of NF-kappaB-inducing kinase activity)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0009617"(response to bacterium)|go:"GO:0030099"(myeloid cell differentiation)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032648"(regulation of interferon-beta production)|go:"GO:0032658"(regulation of interleukin-15 production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032738"(positive regulation of interleukin-15 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0034137"(positive regulation of toll-like receptor 2 signaling pathway)|go:"GO:0034141"(positive regulation of toll-like receptor 3 signaling pathway)|go:"GO:0034145"(positive regulation of toll-like receptor 4 signaling pathway)|go:"GO:0035662"(Toll-like receptor 4 binding)|go:"GO:0035663"(Toll-like receptor 2 binding)|go:"GO:0035665"(TIRAP-dependent toll-like receptor 4 signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045087"(innate immune response)|go:"GO:0045088"(regulation of innate immune response)|go:"GO:0045089"(positive regulation of innate immune response)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070935"(3'-UTR-mediated mRNA stabilization)|go:"GO:0071221"(cellular response to bacterial lipopeptide)|go:"GO:0071223"(cellular response to lipoteichoic acid)|go:"GO:0090023"(positive regulation of neutrophil chemotaxis)|go:"GO:2000340"("positive regulation of chemokine (C-X-C motif) ligand 1 production")|go:"GO:2000343"("positive regulation of chemokine (C-X-C motif) ligand 2 production")|reactome:R-MMU-166058|mint:Q99JY1|refseq:NP_473437.2|interpro:IPR000157(Toll-Interleukin receptor)|interpro:IPR017279(Toll-interleukin 1 receptor domain-containing adaptor protein, Tirap)|interpro:IPR035897	-	-	-	figure legend:Fig. 1G|agonist:LPS|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-bmdc)|taxid:10090(Mus musculus bone marrow-derived dendritic cells)	-	2013/05/15	2014/10/16	rogid:mcGmhHve+Mi2DhcQ7akqBFC0OfI10090	rogid:mzJj4bh3KEi7Mzz273bcpBFP+uk10090	intact-crc:B6F5AAA5A6D3CD7D|rigid:AYXkU7Q8EL+7L4wU2fEccGUloUY	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P58753	uniprotkb:O35350	intact:EBI-528644|uniprotkb:Q8N5E5|uniprotkb:B3KW65|uniprotkb:Q56UI0|uniprotkb:Q56UH9|ensembl:ENSP00000376446|ensembl:ENSP00000376447|ensembl:ENSP00000436967	intact:EBI-6674024|ensembl:ENSMUSP00000025891|ensembl:ENSMUSP00000127498|uniprotkb:O88666	psi-mi:tirap_human(display_long)|uniprotkb:MyD88 adapter-like protein(gene name synonym)|uniprotkb:Adaptor protein Wyatt(gene name synonym)|uniprotkb:TIRAP(gene name)|psi-mi:TIRAP(display_short)|uniprotkb:MAL(gene name synonym)	psi-mi:can1_mouse(display_long)|uniprotkb:Capn1(gene name)|psi-mi:Capn1(display_short)|uniprotkb:Canp1(gene name synonym)|uniprotkb:Capa1(gene name synonym)|uniprotkb:Calcium-activated neutral proteinase 1(gene name synonym)|uniprotkb:Calpain mu-type(gene name synonym)|uniprotkb:Calpain-1 large subunit(gene name synonym)|uniprotkb:Micromolar-calpain(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Aksoy et al. (2012)	pubmed:23023391|imex:IM-20918	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0974"(InnateDB)	intact:EBI-6674023|imex:IM-20918-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001305705.1|refseq:NP_001305706.1|refseq:NP_001034750.1|refseq:NP_683708.1|refseq:XP_005271456.2|refseq:XP_011540878.1|ensembl:ENSG00000150455(gene)|ensembl:ENST00000392679(transcript)|ensembl:ENST00000392680(transcript)|ensembl:ENST00000479770(transcript)|go:"GO:0002755"(MyD88-dependent toll-like receptor signaling pathway)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007250"(activation of NF-kappaB-inducing kinase activity)|go:"GO:0030099"(myeloid cell differentiation)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032648"(regulation of interferon-beta production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032738"(positive regulation of interleukin-15 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0034137"(positive regulation of toll-like receptor 2 signaling pathway)|go:"GO:0034141"(positive regulation of toll-like receptor 3 signaling pathway)|go:"GO:0034145"(positive regulation of toll-like receptor 4 signaling pathway)|go:"GO:0035662"(Toll-like receptor 4 binding)|go:"GO:0035663"(Toll-like receptor 2 binding)|go:"GO:0035665"(TIRAP-dependent toll-like receptor 4 signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045087"(innate immune response)|go:"GO:0045088"(regulation of innate immune response)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070935"(3'-UTR-mediated mRNA stabilization)|go:"GO:0071221"(cellular response to bacterial lipopeptide)|go:"GO:0071223"(cellular response to lipoteichoic acid)|go:"GO:0090023"(positive regulation of neutrophil chemotaxis)|go:"GO:2000340"("positive regulation of chemokine (C-X-C motif) ligand 1 production")|go:"GO:2000343"("positive regulation of chemokine (C-X-C motif) ligand 2 production")|interpro:IPR000157(Toll-Interleukin receptor)|interpro:IPR017279(Toll-interleukin 1 receptor domain-containing adaptor protein, Tirap)|interpro:IPR035897|mint:P58753|rcsb pdb:2NDH|rcsb pdb:2Y92|rcsb pdb:3UB2|rcsb pdb:3UB3|rcsb pdb:3UB4|rcsb pdb:4FZ5|rcsb pdb:4LQD|rcsb pdb:5T7Q|rcsb pdb:5UZB|reactome:R-HSA-1236974|reactome:R-HSA-166058|reactome:R-HSA-5602498|reactome:R-HSA-5603041|refseq:XP_016872651.1|dip:DIP-33489N	ensembl:ENSMUSG00000024942(gene)|ensembl:ENSMUST00000025891(transcript)|ensembl:ENSMUST00000164843(transcript)|go:"GO:0004198"(calcium-dependent cysteine-type endopeptidase activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005764"(lysosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006508"(proteolysis)|reactome:R-MMU-6798695|go:"GO:1990776"(response to angiotensin)|interpro:IPR000169(Peptidase, cysteine peptidase active site)|interpro:IPR001300(Peptidase C2, calpain)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|interpro:IPR022682|interpro:IPR022683|interpro:IPR022684|interpro:IPR029643|interpro:IPR033883|interpro:IPR036213|interpro:IPR038765|mint:O35350|reactome:R-MMU-1474228|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0008233"(peptidase activity)|go:"GO:0010666"(positive regulation of cardiac muscle cell apoptotic process)|go:"GO:0016020"(membrane)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0019899"(enzyme binding)|go:"GO:0030837"(negative regulation of actin filament polymerization)|go:"GO:0032801"(receptor catabolic process)|go:"GO:0043117"(positive regulation of vascular permeability)|go:"GO:0050790"(regulation of catalytic activity)|go:"GO:0060056"(mammary gland involution)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0097264"(self proteolysis)|go:"GO:1901223"(negative regulation of NIK/NF-kappaB signaling)|go:"GO:1903238"(positive regulation of leukocyte tethering or rolling)|refseq:NP_001103974.1|refseq:NP_031626.1|dip:DIP-60303N	-	-	-	figure legend:Fig. 4C|agonist:LPS|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-macrophage)|taxid:10090(Mus musculus macrophage)	-	2013/05/15	2014/10/16	rogid:UmeekccCTOn8783GJqByIj+JIDE9606	rogid:DK0Jv04zuGhiu7j6mllot9Lklbw10090	intact-crc:0DC7F1A1B6B45067|rigid:zg/ENUdFVdXTEFtFvk5iEi/7EkU	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P07384	uniprotkb:P58753	intact:EBI-1542113|uniprotkb:Q2TTR0|uniprotkb:Q6DHV4|ensembl:ENSP00000279247|ensembl:ENSP00000431686|ensembl:ENSP00000431984|ensembl:ENSP00000434176|ensembl:ENSP00000435272	intact:EBI-528644|uniprotkb:Q8N5E5|uniprotkb:B3KW65|uniprotkb:Q56UI0|uniprotkb:Q56UH9|ensembl:ENSP00000376446|ensembl:ENSP00000376447|ensembl:ENSP00000436967	psi-mi:can1_human(display_long)|uniprotkb:CAPN1(gene name)|psi-mi:CAPN1(display_short)|uniprotkb:CANPL1(gene name synonym)|uniprotkb:Calpain-1 large subunit(gene name synonym)|uniprotkb:Calcium-activated neutral proteinase 1(gene name synonym)|uniprotkb:Calpain mu-type(gene name synonym)|uniprotkb:Micromolar-calpain(gene name synonym)|uniprotkb:Cell proliferation-inducing gene 30 protein(gene name synonym)|uniprotkb:PIG30(orf name)	psi-mi:tirap_human(display_long)|uniprotkb:MyD88 adapter-like protein(gene name synonym)|uniprotkb:Adaptor protein Wyatt(gene name synonym)|uniprotkb:TIRAP(gene name)|psi-mi:TIRAP(display_short)|uniprotkb:MAL(gene name synonym)	psi-mi:"MI:0435"(protease assay)	Aksoy et al. (2012)	pubmed:23023391|imex:IM-20918	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0194"(cleavage reaction)	psi-mi:"MI:0974"(InnateDB)	intact:EBI-6674069|imex:IM-20918-4	-	-	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_006718761.1|refseq:NP_001185797.1|refseq:NP_001185798.1|refseq:NP_005177.2|refseq:XP_011543594.1|ensembl:ENSG00000014216(gene)|ensembl:ENST00000279247(transcript)|ensembl:ENST00000524773(transcript)|ensembl:ENST00000527323(transcript)|ensembl:ENST00000533129(transcript)|ensembl:ENST00000533820(transcript)|go:"GO:0004198"(calcium-dependent cysteine-type endopeptidase activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005764"(lysosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006508"(proteolysis)|go:"GO:0008233"(peptidase activity)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016241"(regulation of macroautophagy)|go:"GO:0032801"(receptor catabolic process)|go:"GO:0050790"(regulation of catalytic activity)|go:"GO:0060056"(mammary gland involution)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097264"(self proteolysis)|go:"GO:1904813"(ficolin-1-rich granule lumen)|go:"GO:2000310"(regulation of NMDA receptor activity)|interpro:IPR000169(Peptidase, cysteine peptidase active site)|interpro:IPR001300(Peptidase C2, calpain)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|interpro:IPR022682|interpro:IPR022683|interpro:IPR022684|interpro:IPR029643|interpro:IPR033883|interpro:IPR036213|interpro:IPR038765|mint:P07384|rcsb pdb:1ZCM|rcsb pdb:2ARY|reactome:R-HSA-1474228|reactome:R-HSA-6798695|reactome:R-HSA-6809371|reactome:R-HSA-8862803	refseq:NP_001305705.1|refseq:NP_001305706.1|refseq:NP_001034750.1|refseq:NP_683708.1|refseq:XP_005271456.2|refseq:XP_011540878.1|ensembl:ENSG00000150455(gene)|ensembl:ENST00000392679(transcript)|ensembl:ENST00000392680(transcript)|ensembl:ENST00000479770(transcript)|go:"GO:0002755"(MyD88-dependent toll-like receptor signaling pathway)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007250"(activation of NF-kappaB-inducing kinase activity)|go:"GO:0030099"(myeloid cell differentiation)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032648"(regulation of interferon-beta production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032738"(positive regulation of interleukin-15 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0034137"(positive regulation of toll-like receptor 2 signaling pathway)|go:"GO:0034141"(positive regulation of toll-like receptor 3 signaling pathway)|go:"GO:0034145"(positive regulation of toll-like receptor 4 signaling pathway)|go:"GO:0035662"(Toll-like receptor 4 binding)|go:"GO:0035663"(Toll-like receptor 2 binding)|go:"GO:0035665"(TIRAP-dependent toll-like receptor 4 signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045087"(innate immune response)|go:"GO:0045088"(regulation of innate immune response)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070935"(3'-UTR-mediated mRNA stabilization)|go:"GO:0071221"(cellular response to bacterial lipopeptide)|go:"GO:0071223"(cellular response to lipoteichoic acid)|go:"GO:0090023"(positive regulation of neutrophil chemotaxis)|go:"GO:2000340"("positive regulation of chemokine (C-X-C motif) ligand 1 production")|go:"GO:2000343"("positive regulation of chemokine (C-X-C motif) ligand 2 production")|interpro:IPR000157(Toll-Interleukin receptor)|interpro:IPR017279(Toll-interleukin 1 receptor domain-containing adaptor protein, Tirap)|interpro:IPR035897|mint:P58753|rcsb pdb:2NDH|rcsb pdb:2Y92|rcsb pdb:3UB2|rcsb pdb:3UB3|rcsb pdb:3UB4|rcsb pdb:4FZ5|rcsb pdb:4LQD|rcsb pdb:5T7Q|rcsb pdb:5UZB|reactome:R-HSA-1236974|reactome:R-HSA-166058|reactome:R-HSA-5602498|reactome:R-HSA-5603041|refseq:XP_016872651.1|dip:DIP-33489N	-	-	-	figure legend:Fig. 4D|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/05/15	2014/10/16	rogid:hLf5vu04E7/yonXBb9VIZThbcxk9606	rogid:UmeekccCTOn8783GJqByIj+JIDE9606	intact-crc:378980CB162C2F32|rigid:dRqFVpUDWTkmmvGyYX6CobbN43g	false	-	glutathione s tranferase tag:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q07009	uniprotkb:P58753	intact:EBI-1040438|ensembl:ENSRNOP00000046509	intact:EBI-528644|uniprotkb:Q8N5E5|uniprotkb:B3KW65|uniprotkb:Q56UI0|uniprotkb:Q56UH9|ensembl:ENSP00000376446|ensembl:ENSP00000376447|ensembl:ENSP00000436967	psi-mi:can2_rat(display_long)|uniprotkb:Capn2(gene name)|psi-mi:Capn2(display_short)|uniprotkb:Calpain-2 large subunit(gene name synonym)|uniprotkb:Calcium-activated neutral proteinase 2(gene name synonym)|uniprotkb:Calpain M-type(gene name synonym)|uniprotkb:Millimolar-calpain(gene name synonym)	psi-mi:tirap_human(display_long)|uniprotkb:MyD88 adapter-like protein(gene name synonym)|uniprotkb:Adaptor protein Wyatt(gene name synonym)|uniprotkb:TIRAP(gene name)|psi-mi:TIRAP(display_short)|uniprotkb:MAL(gene name synonym)	psi-mi:"MI:0435"(protease assay)	Aksoy et al. (2012)	pubmed:23023391|imex:IM-20918	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0194"(cleavage reaction)	psi-mi:"MI:0974"(InnateDB)	intact:EBI-6674267|imex:IM-20918-5	-	-	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2268|refseq:NP_058812.1|ensembl:ENSRNOG00000034015(gene)|ensembl:ENSRNOT00000045326(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001824"(blastocyst development)|go:"GO:0004198"(calcium-dependent cysteine-type endopeptidase activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006508"(proteolysis)|go:"GO:0007520"(myoblast fusion)|go:"GO:0007565"(female pregnancy)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0008233"(peptidase activity)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010666"(positive regulation of cardiac muscle cell apoptotic process)|go:"GO:0016020"(membrane)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0019899"(enzyme binding)|go:"GO:0030425"(dendrite)|go:"GO:0031143"(pseudopodium)|go:"GO:0032675"(regulation of interleukin-6 production)|go:"GO:0035458"(cellular response to interferon-beta)|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042995"(cell projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0048266"(behavioral response to pain)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0051603"(proteolysis involved in cellular protein catabolic process)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0097038"(perinuclear endoplasmic reticulum)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1901741"(positive regulation of myoblast fusion)|go:"GO:2001247"(positive regulation of phosphatidylcholine biosynthetic process)|interpro:IPR000169(Peptidase, cysteine peptidase active site)|interpro:IPR001300(Peptidase C2, calpain)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|interpro:IPR022682|interpro:IPR022683|interpro:IPR022684|interpro:IPR029539|interpro:IPR033883|interpro:IPR036213|interpro:IPR038765|interpro:IPR042736|mint:Q07009|rcsb pdb:1DF0|rcsb pdb:1MDW|rcsb pdb:1QXP|rcsb pdb:1U5I|rcsb pdb:3BOW|rcsb pdb:3DF0|reactome:R-RNO-1474228|dip:DIP-6139N	refseq:NP_001305705.1|refseq:NP_001305706.1|refseq:NP_001034750.1|refseq:NP_683708.1|refseq:XP_005271456.2|refseq:XP_011540878.1|ensembl:ENSG00000150455(gene)|ensembl:ENST00000392679(transcript)|ensembl:ENST00000392680(transcript)|ensembl:ENST00000479770(transcript)|go:"GO:0002755"(MyD88-dependent toll-like receptor signaling pathway)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007250"(activation of NF-kappaB-inducing kinase activity)|go:"GO:0030099"(myeloid cell differentiation)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032648"(regulation of interferon-beta production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032738"(positive regulation of interleukin-15 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0034137"(positive regulation of toll-like receptor 2 signaling pathway)|go:"GO:0034141"(positive regulation of toll-like receptor 3 signaling pathway)|go:"GO:0034145"(positive regulation of toll-like receptor 4 signaling pathway)|go:"GO:0035662"(Toll-like receptor 4 binding)|go:"GO:0035663"(Toll-like receptor 2 binding)|go:"GO:0035665"(TIRAP-dependent toll-like receptor 4 signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045087"(innate immune response)|go:"GO:0045088"(regulation of innate immune response)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070935"(3'-UTR-mediated mRNA stabilization)|go:"GO:0071221"(cellular response to bacterial lipopeptide)|go:"GO:0071223"(cellular response to lipoteichoic acid)|go:"GO:0090023"(positive regulation of neutrophil chemotaxis)|go:"GO:2000340"("positive regulation of chemokine (C-X-C motif) ligand 1 production")|go:"GO:2000343"("positive regulation of chemokine (C-X-C motif) ligand 2 production")|interpro:IPR000157(Toll-Interleukin receptor)|interpro:IPR017279(Toll-interleukin 1 receptor domain-containing adaptor protein, Tirap)|interpro:IPR035897|mint:P58753|rcsb pdb:2NDH|rcsb pdb:2Y92|rcsb pdb:3UB2|rcsb pdb:3UB3|rcsb pdb:3UB4|rcsb pdb:4FZ5|rcsb pdb:4LQD|rcsb pdb:5T7Q|rcsb pdb:5UZB|reactome:R-HSA-1236974|reactome:R-HSA-166058|reactome:R-HSA-5602498|reactome:R-HSA-5603041|refseq:XP_016872651.1|dip:DIP-33489N	-	-	-	figure legend:Fig. 4D|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/05/15	2014/10/16	rogid:IAwBkfhb1+PtAZz2QDXOgLsU76I10116	rogid:UmeekccCTOn8783GJqByIj+JIDE9606	intact-crc:2D3CEBC47AD207DF|rigid:7pPiI6u1kDCxke6tdh/oHXI11UU	false	-	glutathione s tranferase tag:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)