#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q63961	uniprotkb:P11688	intact:EBI-7846091|ensembl:ENSMUSP00000009705|uniprotkb:Q61520|intact:UNK-5465340|intact:MINT-4116867|uniprotkb:Q8K100	intact:EBI-6477055|uniprotkb:E9QN40|ensembl:ENSMUSP00000023128	psi-mi:egln_mouse(display_long)|uniprotkb:Eng(gene name)|psi-mi:Eng(display_short)|uniprotkb:Cell surface MJ7/18 antigen(gene name synonym)|uniprotkb:Edg(gene name synonym)	psi-mi:ita5_mouse(display_long)|uniprotkb:Itga5(gene name)|psi-mi:Itga5(display_short)|uniprotkb:CD49 antigen-like family member E(gene name synonym)|uniprotkb:Fibronectin receptor subunit alpha(gene name synonym)|uniprotkb:Integrin alpha-F(gene name synonym)|uniprotkb:VLA-5(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Tian et al. (2012)	pubmed:22940691|imex:IM-18764|mint:MINT-8410211	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8043417|mint:MINT-8410219|imex:IM-18764-11	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0048745"(smooth muscle tissue development)|go:"GO:0048844"(artery morphogenesis)|go:"GO:0032967"(positive regulation of collagen biosynthetic process)|go:"GO:0034713"(type I transforming growth factor beta receptor binding)|go:"GO:0048845"(venous blood vessel morphogenesis)|go:"GO:0048870"(cell motility)|go:"GO:0050431"(transforming growth factor beta binding)|go:"GO:0051001"(negative regulation of nitric-oxide synthase activity)|go:"GO:0035912"(dorsal aorta morphogenesis)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0036122"(BMP binding)|go:"GO:0042060"(wound healing)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0055009"(atrial cardiac muscle tissue morphogenesis)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060394"(negative regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0070278"(extracellular matrix constituent secretion)|go:"GO:0070483"(detection of hypoxia)|go:"GO:0072563"(endothelial microparticle)|go:"GO:0097084"(vascular associated smooth muscle cell development)|go:"GO:1905007"(positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation)|go:"GO:1905065"(positive regulation of vascular associated smooth muscle cell differentiation)|go:"GO:0043235"(receptor complex)|go:"GO:1905222"(atrioventricular canal morphogenesis)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|interpro:IPR001507(Endoglin/CD105 antigen)|mint:Q63961|ensembl:ENSMUST00000009705(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001525"(angiogenesis)|go:"GO:0001569"(branching involved in blood vessel morphogenesis)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0001947"(heart looping)|go:"GO:0003084"(positive regulation of systemic arterial blood pressure)|go:"GO:0003148"(outflow tract septum morphogenesis)|go:"GO:0003198"(epithelial to mesenchymal transition involved in endocardial cushion formation)|go:"GO:0003203"(endocardial cushion morphogenesis)|go:"GO:0003208"(cardiac ventricle morphogenesis)|go:"GO:0003209"(cardiac atrium morphogenesis)|go:"GO:0003222"(ventricular trabecula myocardium morphogenesis)|go:"GO:0003273"(cell migration involved in endocardial cushion formation)|go:"GO:0005024"(transforming growth factor beta-activated receptor activity)|go:"GO:0005114"(type II transforming growth factor beta receptor binding)|go:"GO:0005534"(galactose binding)|ensembl:ENSMUSG00000026814(gene)|go:"GO:0005539"(glycosaminoglycan binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0007155"(cell adhesion)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007507"(heart development)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0015026"(coreceptor activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016477"(cell migration)|go:"GO:0016604"(nuclear body)|go:"GO:0017015"(regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0022009"(central nervous system vasculogenesis)|go:"GO:0022617"(extracellular matrix disassembly)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030513"(positive regulation of BMP signaling pathway)|go:"GO:0031953"(negative regulation of protein autophosphorylation)|refseq:NP_031958.2|dip:DIP-47636N|mint:MINT-8410221(identity)	ensembl:ENSMUSG00000000555(gene)|ensembl:ENSMUST00000023128(transcript)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0007044"(cell-substrate junction assembly)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007565"(female pregnancy)|go:"GO:0007613"(memory)|go:"GO:0008305"(integrin complex)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010811"(positive regulation of cell-substrate adhesion)|go:"GO:0023035"(CD40 signaling pathway)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031589"(cell-substrate adhesion)|go:"GO:0033627"(cell adhesion mediated by integrin)|go:"GO:0033631"(cell-cell adhesion mediated by integrin)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0034674"(integrin alpha5-beta1 complex)|go:"GO:0035987"(endodermal cell differentiation)|go:"GO:0045202"(synapse)|go:"GO:0045765"(regulation of angiogenesis)|go:"GO:0046872"(metal ion binding)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:1903672"(positive regulation of sprouting angiogenesis)|go:"GO:2000811"(negative regulation of anoikis)|interpro:IPR000413(Integrins alpha chain)|interpro:IPR013517(FG-GAP)|interpro:IPR013519(Integrin alpha beta-propellor)|interpro:IPR013649(Integrin alpha-2)|interpro:IPR018184|interpro:IPR028994|interpro:IPR032695|mint:P11688|reactome:R-MMU-1566948|reactome:R-MMU-1566977|reactome:R-MMU-202733|reactome:R-MMU-216083|reactome:R-MMU-445144|refseq:NP_034707.5|mint:MINT-8410222(identity)	-	comment:mint	-	figure legend:f5d|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-meec)|taxid:10090(Mus musculus)	-	2013/01/17	2014/10/16	rogid:Hbop7m12Up7X+y+EN/NSBgMe8nI10090	rogid:nPbagL1WwNP57xKnFh9YRikRAIk10090	intact-crc:13CE7A36B43BCB34|rigid:cz88Vmx7PvBf9ggNOPKTW0CC8lU	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q63961	uniprotkb:P09055	intact:EBI-7846091|ensembl:ENSMUSP00000009705|uniprotkb:Q61520|intact:UNK-5465340|intact:MINT-4116867|uniprotkb:Q8K100	intact:EBI-644224|uniprotkb:F6R105|uniprotkb:Q60993|uniprotkb:Q61126|uniprotkb:Q3TIW5|uniprotkb:Q3TWH6|uniprotkb:Q8BTU0|uniprotkb:Q8BVU1|ensembl:ENSMUSP00000087457	psi-mi:egln_mouse(display_long)|uniprotkb:Eng(gene name)|psi-mi:Eng(display_short)|uniprotkb:Cell surface MJ7/18 antigen(gene name synonym)|uniprotkb:Edg(gene name synonym)	psi-mi:itb1_mouse(display_long)|uniprotkb:Fibronectin receptor subunit beta(gene name synonym)|uniprotkb:VLA-4 subunit beta(gene name synonym)|uniprotkb:Itgb1(gene name)|psi-mi:Itgb1(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Tian et al. (2012)	pubmed:22940691|imex:IM-18764|mint:MINT-8410211	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8043429|mint:MINT-8410228|imex:IM-18764-12	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0048745"(smooth muscle tissue development)|go:"GO:0048844"(artery morphogenesis)|go:"GO:0032967"(positive regulation of collagen biosynthetic process)|go:"GO:0034713"(type I transforming growth factor beta receptor binding)|go:"GO:0048845"(venous blood vessel morphogenesis)|go:"GO:0048870"(cell motility)|go:"GO:0050431"(transforming growth factor beta binding)|go:"GO:0051001"(negative regulation of nitric-oxide synthase activity)|go:"GO:0035912"(dorsal aorta morphogenesis)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0036122"(BMP binding)|go:"GO:0042060"(wound healing)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0055009"(atrial cardiac muscle tissue morphogenesis)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060394"(negative regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0070278"(extracellular matrix constituent secretion)|go:"GO:0070483"(detection of hypoxia)|go:"GO:0072563"(endothelial microparticle)|go:"GO:0097084"(vascular associated smooth muscle cell development)|go:"GO:1905007"(positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation)|go:"GO:1905065"(positive regulation of vascular associated smooth muscle cell differentiation)|go:"GO:0043235"(receptor complex)|go:"GO:1905222"(atrioventricular canal morphogenesis)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|interpro:IPR001507(Endoglin/CD105 antigen)|mint:Q63961|ensembl:ENSMUST00000009705(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001525"(angiogenesis)|go:"GO:0001569"(branching involved in blood vessel morphogenesis)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0001947"(heart looping)|go:"GO:0003084"(positive regulation of systemic arterial blood pressure)|go:"GO:0003148"(outflow tract septum morphogenesis)|go:"GO:0003198"(epithelial to mesenchymal transition involved in endocardial cushion formation)|go:"GO:0003203"(endocardial cushion morphogenesis)|go:"GO:0003208"(cardiac ventricle morphogenesis)|go:"GO:0003209"(cardiac atrium morphogenesis)|go:"GO:0003222"(ventricular trabecula myocardium morphogenesis)|go:"GO:0003273"(cell migration involved in endocardial cushion formation)|go:"GO:0005024"(transforming growth factor beta-activated receptor activity)|go:"GO:0005114"(type II transforming growth factor beta receptor binding)|go:"GO:0005534"(galactose binding)|ensembl:ENSMUSG00000026814(gene)|go:"GO:0005539"(glycosaminoglycan binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0007155"(cell adhesion)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007507"(heart development)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0015026"(coreceptor activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016477"(cell migration)|go:"GO:0016604"(nuclear body)|go:"GO:0017015"(regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0022009"(central nervous system vasculogenesis)|go:"GO:0022617"(extracellular matrix disassembly)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030513"(positive regulation of BMP signaling pathway)|go:"GO:0031953"(negative regulation of protein autophosphorylation)|refseq:NP_031958.2|dip:DIP-47636N|mint:MINT-8410230(identity)	refseq:NP_034708.1|ensembl:ENSMUSG00000025809(gene)|ensembl:ENSMUST00000090006(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0000132"(establishment of mitotic spindle orientation)|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001708"(cell fate specification)|go:"GO:0001894"(tissue homeostasis)|go:"GO:0001968"(fibronectin binding)|go:"GO:0002020"(protease binding)|go:"GO:0002042"(cell migration involved in sprouting angiogenesis)|go:"GO:0003779"(actin binding)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005518"(collagen binding)|go:"GO:0005604"(basement membrane)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005912"(adherens junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0006909"(phagocytosis)|go:"GO:0007155"(cell adhesion)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007161"(calcium-independent cell-matrix adhesion)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0008277"(regulation of G protein-coupled receptor signaling pathway)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014704"(intercalated disc)|go:"GO:0016020"(membrane)|go:"GO:0016477"(cell migration)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008305"(integrin complex)|go:"GO:0008354"(germ cell migration)|go:"GO:0008542"(visual learning)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010710"(regulation of collagen catabolic process)|go:"GO:0010763"(positive regulation of fibroblast migration)|go:"GO:0010811"(positive regulation of cell-substrate adhesion)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0019960"(C-X3-C chemokine binding)|go:"GO:0021943"(formation of radial glial scaffolds)|go:"GO:0023035"(CD40 signaling pathway)|go:"GO:0030027"(lamellipodium)|go:"GO:0030030"(cell projection organization)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0030056"(hemidesmosome)|go:"GO:0030175"(filopodium)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031175"(neuron projection development)|go:"GO:0031345"(negative regulation of cell projection organization)|go:"GO:0031589"(cell-substrate adhesion)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031623"(receptor internalization)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032594"(protein transport within lipid bilayer)|go:"GO:0033627"(cell adhesion mediated by integrin)|go:"GO:0033631"(cell-cell adhesion mediated by integrin)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0034665"(integrin alpha1-beta1 complex)|go:"GO:0034666"(integrin alpha2-beta1 complex)|go:"GO:0034667"(integrin alpha3-beta1 complex)|reactome:R-MMU-445144|reactome:R-MMU-446343|reactome:R-MMU-8874081|reactome:R-MMU-8875513|reactome:R-MMU-9013149|reactome:R-MMU-9013404|go:"GO:0034674"(integrin alpha5-beta1 complex)|reactome:R-MMU-9013408|reactome:R-MMU-9013423|go:"GO:0034679"(integrin alpha9-beta1 complex)|go:"GO:0034680"(integrin alpha10-beta1 complex)|go:"GO:0034681"(integrin alpha11-beta1 complex)|go:"GO:0035024"(negative regulation of Rho protein signal transduction)|go:"GO:0035748"(myelin sheath abaxonal region)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042383"(sarcolemma)|go:"GO:0042470"(melanosome)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043197"(dendritic spine)|go:"GO:0043235"(receptor complex)|go:"GO:0043236"(laminin binding)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045214"(sarcomere organization)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045807"(positive regulation of endocytosis)|go:"GO:0046872"(metal ion binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048333"(mesodermal cell differentiation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048675"(axon extension)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0051393"(alpha-actinin binding)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051951"(positive regulation of glutamate uptake involved in transmission of nerve impulse)|go:"GO:0034677"(integrin alpha7-beta1 complex)|go:"GO:0055037"(recycling endosome)|go:"GO:0070830"(bicellular tight junction assembly)|go:"GO:0071404"(cellular response to low-density lipoprotein particle stimulus)|go:"GO:0071711"(basement membrane organization)|go:"GO:0090303"(positive regulation of wound healing)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097386"(glial cell projection)|go:"GO:0098639"(collagen binding involved in cell-matrix adhesion)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099699"(integral component of synaptic membrane)|go:"GO:0150003"(regulation of spontaneous synaptic transmission)|go:"GO:0150103"(reactive gliosis)|go:"GO:1901979"(regulation of inward rectifier potassium channel activity)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1990782"(protein tyrosine kinase binding)|go:"GO:2000273"(positive regulation of signaling receptor activity)|go:"GO:2000811"(negative regulation of anoikis)|interpro:IPR002369(Integrin beta subunit, N-terminal)|interpro:IPR012896(Integrin beta subunit, tail)|interpro:IPR013111(EGF, extracellular)|interpro:IPR014836(Integrin beta subunit, cytoplasmic)|interpro:IPR015812(Integrin beta subunit)|interpro:IPR016201(Plexin-like fold)|interpro:IPR027071|interpro:IPR032695|interpro:IPR033760|interpro:IPR036349|interpro:IPR036465|interpro:IPR040622|mint:P09055|rcsb pdb:5XQ0|reactome:R-MMU-1566948|reactome:R-MMU-1566977|reactome:R-MMU-198933|reactome:R-MMU-202733|reactome:R-MMU-210991|reactome:R-MMU-2129379|reactome:R-MMU-216083|reactome:R-MMU-3000157|reactome:R-MMU-3000170|reactome:R-MMU-3000178|go:"GO:0055007"(cardiac muscle cell differentiation)|dip:DIP-46247N|mint:MINT-8410232(identity)	-	comment:mint	-	figure legend:f5d|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-meec)|taxid:10090(Mus musculus)	-	2013/01/17	2014/10/16	rogid:Hbop7m12Up7X+y+EN/NSBgMe8nI10090	rogid:jlfpHCJp8eLzWN+3rdIOSG7Ijas10090	intact-crc:B67BAB334153D00C|rigid:W2FfXBCYzY2PdLNAdtqtVQNVed4	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P08648	uniprotkb:P17813	intact:EBI-1382311|uniprotkb:Q96HA5|ensembl:ENSP00000293379	intact:EBI-2834630|uniprotkb:Q5T9C0|uniprotkb:Q14248|uniprotkb:Q14926|ensembl:ENSP00000362299	psi-mi:ita5_human(display_long)|uniprotkb:ITGA5(gene name)|psi-mi:ITGA5(display_short)|uniprotkb:FNRA(gene name synonym)|uniprotkb:Fibronectin receptor subunit alpha(gene name synonym)|uniprotkb:Integrin alpha-F(gene name synonym)|uniprotkb:VLA-5(gene name synonym)|uniprotkb:CD49 antigen-like family member E(gene name synonym)	psi-mi:egln_human(display_long)|uniprotkb:ENG(gene name)|psi-mi:ENG(display_short)|uniprotkb:END(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Tian et al. (2012)	pubmed:22940691|imex:IM-18764|mint:MINT-8410211	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8043466|mint:MINT-8410638|imex:IM-18764-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002196.4|dip:DIP-40037N|ensembl:ENSG00000161638(gene)|ensembl:ENST00000293379(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001618"(virus receptor activity)|go:"GO:0001726"(ruffle)|go:"GO:0005161"(platelet-derived growth factor receptor binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0007155"(cell adhesion)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0008305"(integrin complex)|go:"GO:0009986"(cell surface)|go:"GO:0023035"(CD40 signaling pathway)|go:"GO:0030949"(positive regulation of vascular endothelial growth factor receptor signaling pathway)|go:"GO:0031589"(cell-substrate adhesion)|go:"GO:0033627"(cell adhesion mediated by integrin)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0034674"(integrin alpha5-beta1 complex)|go:"GO:0035313"(wound healing, spreading of epidermal cells)|go:"GO:0035987"(endodermal cell differentiation)|go:"GO:0043184"(vascular endothelial growth factor receptor 2 binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0071062"(alphav-beta3 integrin-vitronectin complex)|go:"GO:1903672"(positive regulation of sprouting angiogenesis)|go:"GO:2000811"(negative regulation of anoikis)|interpro:IPR000413(Integrins alpha chain)|interpro:IPR013517(FG-GAP)|interpro:IPR013519(Integrin alpha beta-propellor)|interpro:IPR013649(Integrin alpha-2)|interpro:IPR018184|interpro:IPR028994|interpro:IPR032695|mint:P08648|rcsb pdb:3VI3|rcsb pdb:3VI4|rcsb pdb:4WJK|rcsb pdb:4WK0|rcsb pdb:4WK2|rcsb pdb:4WK4|rcsb pdb:7NWL|reactome:R-HSA-1566948|reactome:R-HSA-1566977|reactome:R-HSA-202733|reactome:R-HSA-216083|reactome:R-HSA-445144|reactome:R-HSA-8941332|mint:MINT-8410640(identity)	go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0007155"(cell adhesion)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0015026"(coreceptor activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016477"(cell migration)|go:"GO:0016604"(nuclear body)|go:"GO:0017015"(regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0022009"(central nervous system vasculogenesis)|go:"GO:0022617"(extracellular matrix disassembly)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0005539"(glycosaminoglycan binding)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030513"(positive regulation of BMP signaling pathway)|go:"GO:0031953"(negative regulation of protein autophosphorylation)|go:"GO:0031960"(response to corticosteroid)|go:"GO:0032967"(positive regulation of collagen biosynthetic process)|go:"GO:0034713"(type I transforming growth factor beta receptor binding)|go:"GO:0035912"(dorsal aorta morphogenesis)|go:"GO:0042060"(wound healing)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042325"(regulation of phosphorylation)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043235"(receptor complex)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048185"(activin binding)|go:"GO:0048745"(smooth muscle tissue development)|go:"GO:0048844"(artery morphogenesis)|go:"GO:0048845"(venous blood vessel morphogenesis)|go:"GO:0048870"(cell motility)|go:"GO:0050431"(transforming growth factor beta binding)|go:"GO:0051001"(negative regulation of nitric-oxide synthase activity)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0055009"(atrial cardiac muscle tissue morphogenesis)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060348"(bone development)|go:"GO:0060394"(negative regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0070278"(extracellular matrix constituent secretion)|go:"GO:0070483"(detection of hypoxia)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0072563"(endothelial microparticle)|go:"GO:0097084"(vascular associated smooth muscle cell development)|go:"GO:1905007"(positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation)|go:"GO:1905065"(positive regulation of vascular associated smooth muscle cell differentiation)|go:"GO:1905222"(atrioventricular canal morphogenesis)|interpro:IPR001507(Endoglin/CD105 antigen)|mint:P17813|rcsb pdb:5HZV|rcsb pdb:5HZW|rcsb pdb:5I04|ensembl:ENSG00000106991(gene)|ensembl:ENST00000373203(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001525"(angiogenesis)|go:"GO:0001569"(branching involved in blood vessel morphogenesis)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0001947"(heart looping)|go:"GO:0003084"(positive regulation of systemic arterial blood pressure)|go:"GO:0003148"(outflow tract septum morphogenesis)|go:"GO:0003198"(epithelial to mesenchymal transition involved in endocardial cushion formation)|go:"GO:0003203"(endocardial cushion morphogenesis)|go:"GO:0003208"(cardiac ventricle morphogenesis)|go:"GO:0003209"(cardiac atrium morphogenesis)|go:"GO:0003222"(ventricular trabecula myocardium morphogenesis)|go:"GO:0003273"(cell migration involved in endocardial cushion formation)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005024"(transforming growth factor beta-activated receptor activity)|go:"GO:0005114"(type II transforming growth factor beta receptor binding)|go:"GO:0005534"(galactose binding)|go:"GO:0001570"(vasculogenesis)|refseq:NP_000109.1|refseq:NP_001108225.1|refseq:NP_001265067.1|dip:DIP-6246N|mint:MINT-8410641(identity)	-	-	-	comment:homomint|comment:mint|figure legend:F5A F5F F5G SF12 SF15|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9534(chlae-cos_7)|taxid:9534(Cercopithecus aethiops simian cells transformed with SV40)	-	2013/01/17	2014/10/16	rogid:Wv2ronpU6TmRP0kwlWisA2ObEbI9606	rogid:6+7wUY8XztGVcjgbUlGaRjvBIK89606	intact-crc:C07F4137F213C1EB|rigid:Jq+iC4MvGy6GcghhlpMpen1SWiE	false	green fluorescent protein tag:?-?(MINT-8410662)	ha tag:?-?(MINT-8410648)	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P17813	uniprotkb:P05556	intact:EBI-2834630|uniprotkb:Q5T9C0|uniprotkb:Q14248|uniprotkb:Q14926|ensembl:ENSP00000362299	intact:EBI-703066|intact:EBI-4289597|ensembl:ENSP00000303351|ensembl:ENSP00000379350|ensembl:ENSP00000398029|ensembl:ENSP00000404546|ensembl:ENSP00000502882|ensembl:ENSP00000503546|ensembl:ENSP00000503916|ensembl:ENSP00000504205|ensembl:ENSP00000504444|uniprotkb:Q7Z3V1|uniprotkb:Q8WUM6|uniprotkb:P78466|uniprotkb:P78467|uniprotkb:Q13089|uniprotkb:Q13090|uniprotkb:Q13091|uniprotkb:Q13212|uniprotkb:Q14622|uniprotkb:Q14647|uniprotkb:A8K6N2|uniprotkb:Q29RW2|uniprotkb:D3DRX9|uniprotkb:D3DRY3|uniprotkb:D3DRY4|uniprotkb:D3DRY5	psi-mi:egln_human(display_long)|uniprotkb:ENG(gene name)|psi-mi:ENG(display_short)|uniprotkb:END(gene name synonym)	psi-mi:itb1_human(display_long)|uniprotkb:Fibronectin receptor subunit beta(gene name synonym)|uniprotkb:VLA-4 subunit beta(gene name synonym)|uniprotkb:ITGB1(gene name)|psi-mi:ITGB1(display_short)|uniprotkb:FNRB(gene name synonym)|uniprotkb:MDF2(gene name synonym)|uniprotkb:MSK12(gene name synonym)|uniprotkb:Glycoprotein IIa(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Tian et al. (2012)	pubmed:22940691|imex:IM-18764|mint:MINT-8410211	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8043485|mint:MINT-8410698|imex:IM-18764-6	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0007155"(cell adhesion)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0015026"(coreceptor activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016477"(cell migration)|go:"GO:0016604"(nuclear body)|go:"GO:0017015"(regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0022009"(central nervous system vasculogenesis)|go:"GO:0022617"(extracellular matrix disassembly)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0005539"(glycosaminoglycan binding)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030513"(positive regulation of BMP signaling pathway)|go:"GO:0031953"(negative regulation of protein autophosphorylation)|go:"GO:0031960"(response to corticosteroid)|go:"GO:0032967"(positive regulation of collagen biosynthetic process)|go:"GO:0034713"(type I transforming growth factor beta receptor binding)|go:"GO:0035912"(dorsal aorta morphogenesis)|go:"GO:0042060"(wound healing)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042325"(regulation of phosphorylation)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043235"(receptor complex)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048185"(activin binding)|go:"GO:0048745"(smooth muscle tissue development)|go:"GO:0048844"(artery morphogenesis)|go:"GO:0048845"(venous blood vessel morphogenesis)|go:"GO:0048870"(cell motility)|go:"GO:0050431"(transforming growth factor beta binding)|go:"GO:0051001"(negative regulation of nitric-oxide synthase activity)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0055009"(atrial cardiac muscle tissue morphogenesis)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060348"(bone development)|go:"GO:0060394"(negative regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0070278"(extracellular matrix constituent secretion)|go:"GO:0070483"(detection of hypoxia)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0072563"(endothelial microparticle)|go:"GO:0097084"(vascular associated smooth muscle cell development)|go:"GO:1905007"(positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation)|go:"GO:1905065"(positive regulation of vascular associated smooth muscle cell differentiation)|go:"GO:1905222"(atrioventricular canal morphogenesis)|interpro:IPR001507(Endoglin/CD105 antigen)|mint:P17813|rcsb pdb:5HZV|rcsb pdb:5HZW|rcsb pdb:5I04|ensembl:ENSG00000106991(gene)|ensembl:ENST00000373203(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001525"(angiogenesis)|go:"GO:0001569"(branching involved in blood vessel morphogenesis)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0001947"(heart looping)|go:"GO:0003084"(positive regulation of systemic arterial blood pressure)|go:"GO:0003148"(outflow tract septum morphogenesis)|go:"GO:0003198"(epithelial to mesenchymal transition involved in endocardial cushion formation)|go:"GO:0003203"(endocardial cushion morphogenesis)|go:"GO:0003208"(cardiac ventricle morphogenesis)|go:"GO:0003209"(cardiac atrium morphogenesis)|go:"GO:0003222"(ventricular trabecula myocardium morphogenesis)|go:"GO:0003273"(cell migration involved in endocardial cushion formation)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005024"(transforming growth factor beta-activated receptor activity)|go:"GO:0005114"(type II transforming growth factor beta receptor binding)|go:"GO:0005534"(galactose binding)|go:"GO:0001570"(vasculogenesis)|refseq:NP_000109.1|refseq:NP_001108225.1|refseq:NP_001265067.1|dip:DIP-6246N|mint:MINT-8410700(identity)	go:"GO:0001618"(virus receptor activity)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001708"(cell fate specification)|go:"GO:0001726"(ruffle)|go:"GO:0001968"(fibronectin binding)|go:"GO:0002020"(protease binding)|go:"GO:0002042"(cell migration involved in sprouting angiogenesis)|go:"GO:0003779"(actin binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006909"(phagocytosis)|go:"GO:0006968"(cellular defense response)|go:"GO:0007155"(cell adhesion)|go:"GO:0007156"(homophilic cell adhesion via plasma membrane adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007161"(calcium-independent cell-matrix adhesion)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008354"(germ cell migration)|go:"GO:0008542"(visual learning)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010008"(endosome membrane)|go:"GO:0010710"(regulation of collagen catabolic process)|go:"GO:0010763"(positive regulation of fibroblast migration)|go:"GO:0014704"(intercalated disc)|go:"GO:0015026"(coreceptor activity)|go:"GO:0016020"(membrane)|go:"GO:0016477"(cell migration)|go:"GO:0021943"(formation of radial glial scaffolds)|go:"GO:0023035"(CD40 signaling pathway)|go:"GO:0030027"(lamellipodium)|go:"GO:0030030"(cell projection organization)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031589"(cell-substrate adhesion)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031623"(receptor internalization)|go:"GO:0032154"(cleavage furrow)|go:"GO:0032587"(ruffle membrane)|go:"GO:0033627"(cell adhesion mediated by integrin)|go:"GO:0033631"(cell-cell adhesion mediated by integrin)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0034665"(integrin alpha1-beta1 complex)|go:"GO:0034666"(integrin alpha2-beta1 complex)|go:"GO:0034667"(integrin alpha3-beta1 complex)|go:"GO:0034668"(integrin alpha4-beta1 complex)|go:"GO:0034674"(integrin alpha5-beta1 complex)|go:"GO:0034677"(integrin alpha7-beta1 complex)|go:"GO:0034678"(integrin alpha8-beta1 complex)|go:"GO:0034680"(integrin alpha10-beta1 complex)|go:"GO:0034681"(integrin alpha11-beta1 complex)|go:"GO:0035024"(negative regulation of Rho protein signal transduction)|go:"GO:0035633"(maintenance of blood-brain barrier)|go:"GO:0035748"(myelin sheath abaxonal region)|go:"GO:0042383"(sarcolemma)|go:"GO:0042470"(melanosome)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043197"(dendritic spine)|go:"GO:0043235"(receptor complex)|go:"GO:0043236"(laminin binding)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045214"(sarcomere organization)|go:"GO:0045296"(cadherin binding)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0046872"(metal ion binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048333"(mesodermal cell differentiation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048675"(axon extension)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051951"(positive regulation of glutamate uptake involved in transmission of nerve impulse)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0055037"(recycling endosome)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071404"(cellular response to low-density lipoprotein particle stimulus)|go:"GO:0071711"(basement membrane organization)|go:"GO:0090303"(positive regulation of wound healing)|go:"GO:0097386"(glial cell projection)|go:"GO:0098639"(collagen binding involved in cell-matrix adhesion)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099699"(integral component of synaptic membrane)|go:"GO:0150003"(regulation of spontaneous synaptic transmission)|go:"GO:0150103"(reactive gliosis)|go:"GO:1901979"(regulation of inward rectifier potassium channel activity)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1990782"(protein tyrosine kinase binding)|go:"GO:2000273"(positive regulation of signaling receptor activity)|go:"GO:2000811"(negative regulation of anoikis)|interpro:IPR002369(Integrin beta subunit, N-terminal)|interpro:IPR012896(Integrin beta subunit, tail)|interpro:IPR013111(EGF, extracellular)|interpro:IPR014836(Integrin beta subunit, cytoplasmic)|interpro:IPR015812(Integrin beta subunit)|interpro:IPR016201(Plexin-like fold)|interpro:IPR027071|interpro:IPR032695|interpro:IPR033760|interpro:IPR036349|interpro:IPR036465|interpro:IPR040622|mint:P05556|rcsb pdb:1K11|rcsb pdb:1LHA|rcsb pdb:3G9W|rcsb pdb:3T9K|rcsb pdb:3VI3|rcsb pdb:3VI4|rcsb pdb:4DX9|rcsb pdb:4WJK|rcsb pdb:4WK0|rcsb pdb:4WK2|rcsb pdb:4WK4|rcsb pdb:7CEB|rcsb pdb:7CEC|rcsb pdb:7NWL|reactome:R-HSA-1566948|reactome:R-HSA-1566977|reactome:R-HSA-198933|ensembl:ENSG00000150093(gene)|ensembl:ENST00000302278(transcript)|ensembl:ENST00000396033(transcript)|ensembl:ENST00000417122(transcript)|ensembl:ENST00000437302(transcript)|ensembl:ENST00000677999(transcript)|ensembl:ENST00000678701(transcript)|ensembl:ENST00000678943(transcript)|ensembl:ENST00000678952(transcript)|ensembl:ENST00000678989(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0000132"(establishment of mitotic spindle orientation)|refseq:NP_002202.2|refseq:NP_391988.1|refseq:NP_596867.1|dip:DIP-312N|reactome:R-HSA-202733|reactome:R-HSA-210991|reactome:R-HSA-2129379|reactome:R-HSA-216083|reactome:R-HSA-3000157|reactome:R-HSA-3000170|reactome:R-HSA-3000178|reactome:R-HSA-416700|reactome:R-HSA-445144|reactome:R-HSA-446343|reactome:R-HSA-447041|reactome:R-HSA-5663220|reactome:R-HSA-6785807|reactome:R-HSA-75892|reactome:R-HSA-8874081|reactome:R-HSA-8875513|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013408|reactome:R-HSA-9013423|reactome:R-HSA-9609690|reactome:R-HSA-9679191|mint:MINT-8410704(identity)	-	-	-	comment:homomint|comment:mint|figure legend:F5H|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9534(chlae-cos_7)|taxid:9534(Cercopithecus aethiops simian cells transformed with SV40)	-	2013/01/17	2014/10/16	rogid:6+7wUY8XztGVcjgbUlGaRjvBIK89606	rogid:FZ+lMRS6Zq07A8Lgmf5C6vEXUgM9606	intact-crc:10EC9822D508F4EC|rigid:+ijWHtj4x/JW7wiMJu1VFID1sFI	false	ha tag:?-?(MINT-8410701)	green fluorescent protein tag:?-?(MINT-8410705)	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P17813	uniprotkb:P05556	intact:EBI-2834630|uniprotkb:Q5T9C0|uniprotkb:Q14248|uniprotkb:Q14926|ensembl:ENSP00000362299	intact:EBI-703066|intact:EBI-4289597|ensembl:ENSP00000303351|ensembl:ENSP00000379350|ensembl:ENSP00000398029|ensembl:ENSP00000404546|ensembl:ENSP00000502882|ensembl:ENSP00000503546|ensembl:ENSP00000503916|ensembl:ENSP00000504205|ensembl:ENSP00000504444|uniprotkb:Q7Z3V1|uniprotkb:Q8WUM6|uniprotkb:P78466|uniprotkb:P78467|uniprotkb:Q13089|uniprotkb:Q13090|uniprotkb:Q13091|uniprotkb:Q13212|uniprotkb:Q14622|uniprotkb:Q14647|uniprotkb:A8K6N2|uniprotkb:Q29RW2|uniprotkb:D3DRX9|uniprotkb:D3DRY3|uniprotkb:D3DRY4|uniprotkb:D3DRY5	psi-mi:egln_human(display_long)|uniprotkb:ENG(gene name)|psi-mi:ENG(display_short)|uniprotkb:END(gene name synonym)	psi-mi:itb1_human(display_long)|uniprotkb:Fibronectin receptor subunit beta(gene name synonym)|uniprotkb:VLA-4 subunit beta(gene name synonym)|uniprotkb:ITGB1(gene name)|psi-mi:ITGB1(display_short)|uniprotkb:FNRB(gene name synonym)|uniprotkb:MDF2(gene name synonym)|uniprotkb:MSK12(gene name synonym)|uniprotkb:Glycoprotein IIa(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Tian et al. (2012)	pubmed:22940691|imex:IM-18764|mint:MINT-8410211	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8043503|mint:MINT-8410725|imex:IM-18764-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0007155"(cell adhesion)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0015026"(coreceptor activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016477"(cell migration)|go:"GO:0016604"(nuclear body)|go:"GO:0017015"(regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0022009"(central nervous system vasculogenesis)|go:"GO:0022617"(extracellular matrix disassembly)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0005539"(glycosaminoglycan binding)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030513"(positive regulation of BMP signaling pathway)|go:"GO:0031953"(negative regulation of protein autophosphorylation)|go:"GO:0031960"(response to corticosteroid)|go:"GO:0032967"(positive regulation of collagen biosynthetic process)|go:"GO:0034713"(type I transforming growth factor beta receptor binding)|go:"GO:0035912"(dorsal aorta morphogenesis)|go:"GO:0042060"(wound healing)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042325"(regulation of phosphorylation)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043235"(receptor complex)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048185"(activin binding)|go:"GO:0048745"(smooth muscle tissue development)|go:"GO:0048844"(artery morphogenesis)|go:"GO:0048845"(venous blood vessel morphogenesis)|go:"GO:0048870"(cell motility)|go:"GO:0050431"(transforming growth factor beta binding)|go:"GO:0051001"(negative regulation of nitric-oxide synthase activity)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0055009"(atrial cardiac muscle tissue morphogenesis)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060348"(bone development)|go:"GO:0060394"(negative regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0070278"(extracellular matrix constituent secretion)|go:"GO:0070483"(detection of hypoxia)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0072563"(endothelial microparticle)|go:"GO:0097084"(vascular associated smooth muscle cell development)|go:"GO:1905007"(positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation)|go:"GO:1905065"(positive regulation of vascular associated smooth muscle cell differentiation)|go:"GO:1905222"(atrioventricular canal morphogenesis)|interpro:IPR001507(Endoglin/CD105 antigen)|mint:P17813|rcsb pdb:5HZV|rcsb pdb:5HZW|rcsb pdb:5I04|ensembl:ENSG00000106991(gene)|ensembl:ENST00000373203(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001525"(angiogenesis)|go:"GO:0001569"(branching involved in blood vessel morphogenesis)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0001947"(heart looping)|go:"GO:0003084"(positive regulation of systemic arterial blood pressure)|go:"GO:0003148"(outflow tract septum morphogenesis)|go:"GO:0003198"(epithelial to mesenchymal transition involved in endocardial cushion formation)|go:"GO:0003203"(endocardial cushion morphogenesis)|go:"GO:0003208"(cardiac ventricle morphogenesis)|go:"GO:0003209"(cardiac atrium morphogenesis)|go:"GO:0003222"(ventricular trabecula myocardium morphogenesis)|go:"GO:0003273"(cell migration involved in endocardial cushion formation)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005024"(transforming growth factor beta-activated receptor activity)|go:"GO:0005114"(type II transforming growth factor beta receptor binding)|go:"GO:0005534"(galactose binding)|go:"GO:0001570"(vasculogenesis)|refseq:NP_000109.1|refseq:NP_001108225.1|refseq:NP_001265067.1|dip:DIP-6246N|mint:MINT-8410731(identity)	go:"GO:0001618"(virus receptor activity)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001708"(cell fate specification)|go:"GO:0001726"(ruffle)|go:"GO:0001968"(fibronectin binding)|go:"GO:0002020"(protease binding)|go:"GO:0002042"(cell migration involved in sprouting angiogenesis)|go:"GO:0003779"(actin binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006909"(phagocytosis)|go:"GO:0006968"(cellular defense response)|go:"GO:0007155"(cell adhesion)|go:"GO:0007156"(homophilic cell adhesion via plasma membrane adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007161"(calcium-independent cell-matrix adhesion)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008354"(germ cell migration)|go:"GO:0008542"(visual learning)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010008"(endosome membrane)|go:"GO:0010710"(regulation of collagen catabolic process)|go:"GO:0010763"(positive regulation of fibroblast migration)|go:"GO:0014704"(intercalated disc)|go:"GO:0015026"(coreceptor activity)|go:"GO:0016020"(membrane)|go:"GO:0016477"(cell migration)|go:"GO:0021943"(formation of radial glial scaffolds)|go:"GO:0023035"(CD40 signaling pathway)|go:"GO:0030027"(lamellipodium)|go:"GO:0030030"(cell projection organization)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031589"(cell-substrate adhesion)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031623"(receptor internalization)|go:"GO:0032154"(cleavage furrow)|go:"GO:0032587"(ruffle membrane)|go:"GO:0033627"(cell adhesion mediated by integrin)|go:"GO:0033631"(cell-cell adhesion mediated by integrin)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0034665"(integrin alpha1-beta1 complex)|go:"GO:0034666"(integrin alpha2-beta1 complex)|go:"GO:0034667"(integrin alpha3-beta1 complex)|go:"GO:0034668"(integrin alpha4-beta1 complex)|go:"GO:0034674"(integrin alpha5-beta1 complex)|go:"GO:0034677"(integrin alpha7-beta1 complex)|go:"GO:0034678"(integrin alpha8-beta1 complex)|go:"GO:0034680"(integrin alpha10-beta1 complex)|go:"GO:0034681"(integrin alpha11-beta1 complex)|go:"GO:0035024"(negative regulation of Rho protein signal transduction)|go:"GO:0035633"(maintenance of blood-brain barrier)|go:"GO:0035748"(myelin sheath abaxonal region)|go:"GO:0042383"(sarcolemma)|go:"GO:0042470"(melanosome)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043197"(dendritic spine)|go:"GO:0043235"(receptor complex)|go:"GO:0043236"(laminin binding)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045214"(sarcomere organization)|go:"GO:0045296"(cadherin binding)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0046872"(metal ion binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048333"(mesodermal cell differentiation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048675"(axon extension)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051951"(positive regulation of glutamate uptake involved in transmission of nerve impulse)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0055037"(recycling endosome)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071404"(cellular response to low-density lipoprotein particle stimulus)|go:"GO:0071711"(basement membrane organization)|go:"GO:0090303"(positive regulation of wound healing)|go:"GO:0097386"(glial cell projection)|go:"GO:0098639"(collagen binding involved in cell-matrix adhesion)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099699"(integral component of synaptic membrane)|go:"GO:0150003"(regulation of spontaneous synaptic transmission)|go:"GO:0150103"(reactive gliosis)|go:"GO:1901979"(regulation of inward rectifier potassium channel activity)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1990782"(protein tyrosine kinase binding)|go:"GO:2000273"(positive regulation of signaling receptor activity)|go:"GO:2000811"(negative regulation of anoikis)|interpro:IPR002369(Integrin beta subunit, N-terminal)|interpro:IPR012896(Integrin beta subunit, tail)|interpro:IPR013111(EGF, extracellular)|interpro:IPR014836(Integrin beta subunit, cytoplasmic)|interpro:IPR015812(Integrin beta subunit)|interpro:IPR016201(Plexin-like fold)|interpro:IPR027071|interpro:IPR032695|interpro:IPR033760|interpro:IPR036349|interpro:IPR036465|interpro:IPR040622|mint:P05556|rcsb pdb:1K11|rcsb pdb:1LHA|rcsb pdb:3G9W|rcsb pdb:3T9K|rcsb pdb:3VI3|rcsb pdb:3VI4|rcsb pdb:4DX9|rcsb pdb:4WJK|rcsb pdb:4WK0|rcsb pdb:4WK2|rcsb pdb:4WK4|rcsb pdb:7CEB|rcsb pdb:7CEC|rcsb pdb:7NWL|reactome:R-HSA-1566948|reactome:R-HSA-1566977|reactome:R-HSA-198933|ensembl:ENSG00000150093(gene)|ensembl:ENST00000302278(transcript)|ensembl:ENST00000396033(transcript)|ensembl:ENST00000417122(transcript)|ensembl:ENST00000437302(transcript)|ensembl:ENST00000677999(transcript)|ensembl:ENST00000678701(transcript)|ensembl:ENST00000678943(transcript)|ensembl:ENST00000678952(transcript)|ensembl:ENST00000678989(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0000132"(establishment of mitotic spindle orientation)|refseq:NP_002202.2|refseq:NP_391988.1|refseq:NP_596867.1|dip:DIP-312N|reactome:R-HSA-202733|reactome:R-HSA-210991|reactome:R-HSA-2129379|reactome:R-HSA-216083|reactome:R-HSA-3000157|reactome:R-HSA-3000170|reactome:R-HSA-3000178|reactome:R-HSA-416700|reactome:R-HSA-445144|reactome:R-HSA-446343|reactome:R-HSA-447041|reactome:R-HSA-5663220|reactome:R-HSA-6785807|reactome:R-HSA-75892|reactome:R-HSA-8874081|reactome:R-HSA-8875513|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013408|reactome:R-HSA-9013423|reactome:R-HSA-9609690|reactome:R-HSA-9679191|mint:MINT-8410727(identity)	-	-	-	comment:homomint|comment:mint|figure legend:F5B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9534(chlae-cos_7)|taxid:9534(Cercopithecus aethiops simian cells transformed with SV40)	-	2013/01/17	2014/10/16	rogid:6+7wUY8XztGVcjgbUlGaRjvBIK89606	rogid:FZ+lMRS6Zq07A8Lgmf5C6vEXUgM9606	intact-crc:8AB68E7D6AC18200|rigid:+ijWHtj4x/JW7wiMJu1VFID1sFI	false	ha tag:?-?(MINT-8410732)	-	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P36897	uniprotkb:P08648	intact:EBI-1027557|uniprotkb:Q6IR47|uniprotkb:Q706C0|uniprotkb:Q706C1|ensembl:ENSP00000364133	intact:EBI-1382311|uniprotkb:Q96HA5|ensembl:ENSP00000293379	psi-mi:tgfr1_human(display_long)|uniprotkb:TGFBR1(gene name)|psi-mi:TGFBR1(display_short)|uniprotkb:Transforming growth factor-beta receptor type I(gene name synonym)|uniprotkb:TGF-beta type I receptor(gene name synonym)|uniprotkb:Serine/threonine-protein kinase receptor R4(gene name synonym)|uniprotkb:Activin receptor-like kinase 5(gene name synonym)|uniprotkb:ALK5(gene name synonym)|uniprotkb:SKR4(gene name synonym)|uniprotkb:Activin A receptor type II-like protein kinase of 53kD(gene name synonym)	psi-mi:ita5_human(display_long)|uniprotkb:ITGA5(gene name)|psi-mi:ITGA5(display_short)|uniprotkb:FNRA(gene name synonym)|uniprotkb:Fibronectin receptor subunit alpha(gene name synonym)|uniprotkb:Integrin alpha-F(gene name synonym)|uniprotkb:VLA-5(gene name synonym)|uniprotkb:CD49 antigen-like family member E(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Tian et al. (2012)	pubmed:22940691|imex:IM-18764|mint:MINT-8410211	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8043535|mint:MINT-8410738|imex:IM-18764-8	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001293139.1|ensembl:ENSG00000106799(gene)|ensembl:ENST00000374994(transcript)|go:"GO:0001501"(skeletal system development)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001822"(kidney development)|go:"GO:0001824"(blastocyst development)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0002088"(lens development in camera-type eye)|go:"GO:0003222"(ventricular trabecula myocardium morphogenesis)|go:"GO:0003223"(ventricular compact myocardium morphogenesis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005024"(transforming growth factor beta-activated receptor activity)|go:"GO:0005025"(transforming growth factor beta receptor activity, type I)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0005114"(type II transforming growth factor beta receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005768"(endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007399"(nervous system development)|go:"GO:0007507"(heart development)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008354"(germ cell migration)|go:"GO:0008584"(male gonad development)|go:"GO:0009791"(post-embryonic development)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0009986"(cell surface)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010717"(regulation of epithelial to mesenchymal transition)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0016020"(membrane)|go:"GO:0016361"(activin receptor activity, type I)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0030199"(collagen fibril organization)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031396"(regulation of protein ubiquitination)|go:"GO:0032331"(negative regulation of chondrocyte differentiation)|go:"GO:0032924"(activin receptor signaling pathway)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042060"(wound healing)|go:"GO:0042118"(endothelial cell activation)|go:"GO:0043062"(extracellular structure organization)|go:"GO:0043235"(receptor complex)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043542"(endothelial cell migration)|go:"GO:0045121"(membrane raft)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046332"(SMAD binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0048179"(activin receptor complex)|go:"GO:0048185"(activin binding)|go:"GO:0048538"(thymus development)|go:"GO:0048663"(neuron fate commitment)|go:"GO:0048701"(embryonic cranial skeleton morphogenesis)|go:"GO:0048705"(skeletal system morphogenesis)|go:"GO:0048762"(mesenchymal cell differentiation)|go:"GO:0048844"(artery morphogenesis)|go:"GO:0048870"(cell motility)|go:"GO:0050431"(transforming growth factor beta binding)|go:"GO:0051272"(positive regulation of cellular component movement)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0060317"(cardiac epithelial to mesenchymal transition)|go:"GO:0060389"(pathway-restricted SMAD protein phosphorylation)|go:"GO:0060391"(positive regulation of SMAD protein signal transduction)|go:"GO:0060412"(ventricular septum morphogenesis)|go:"GO:0060017"(parathyroid gland development)|go:"GO:0060978"(angiogenesis involved in coronary vascular morphogenesis)|go:"GO:0060982"(coronary artery morphogenesis)|go:"GO:0070411"(I-SMAD binding)|go:"GO:0070723"(response to cholesterol)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:1905007"(positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation)|go:"GO:1905075"(positive regulation of tight junction disassembly)|go:"GO:1905223"(epicardium morphogenesis)|go:"GO:2001235"(positive regulation of apoptotic signaling pathway)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR000333(Activin type II receptor)|interpro:IPR000472(TGF-beta receptor/activin receptor, type I/II)|interpro:IPR000719(Protein kinase, core)|go:"GO:0060021"(roof of mouth development)|interpro:IPR003605(TGF beta receptor, GS motif)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P36897|rcsb pdb:1B6C|rcsb pdb:1IAS|rcsb pdb:1PY5|rcsb pdb:1RW8|rcsb pdb:1TBI|rcsb pdb:1VJY|rcsb pdb:2L5S|rcsb pdb:2PJY|rcsb pdb:2WOT|rcsb pdb:2WOU|rcsb pdb:2X7O|rcsb pdb:3FAA|rcsb pdb:3GXL|rcsb pdb:3HMM|rcsb pdb:3KCF|rcsb pdb:3KFD|rcsb pdb:3TZM|rcsb pdb:4X0M|rcsb pdb:4X2F|rcsb pdb:4X2G|rcsb pdb:4X2J|rcsb pdb:4X2K|rcsb pdb:4X2N|rcsb pdb:5E8S|rcsb pdb:5E8T|rcsb pdb:5E8U|rcsb pdb:5E8W|rcsb pdb:5E8X|rcsb pdb:5E8Z|rcsb pdb:5E90|rcsb pdb:5FRI|rcsb pdb:5QIK|rcsb pdb:5QIL|rcsb pdb:5QIM|rcsb pdb:5QTZ|rcsb pdb:5QU0|rcsb pdb:5USQ|go:"GO:0060037"(pharyngeal system development)|rcsb pdb:6B8Y|rcsb pdb:6MAC|reactome:R-HSA-2173788|reactome:R-HSA-2173789|reactome:R-HSA-2173791|reactome:R-HSA-3304356|reactome:R-HSA-3645790|reactome:R-HSA-3656532|reactome:R-HSA-3656535|go:"GO:0060043"(regulation of cardiac muscle cell proliferation)|reactome:R-HSA-5689603|reactome:R-HSA-5689880|refseq:NP_001124388.1|refseq:NP_004603.1|dip:DIP-5935N|mint:MINT-8410740(identity)	refseq:NP_002196.4|dip:DIP-40037N|ensembl:ENSG00000161638(gene)|ensembl:ENST00000293379(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001618"(virus receptor activity)|go:"GO:0001726"(ruffle)|go:"GO:0005161"(platelet-derived growth factor receptor binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0007155"(cell adhesion)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0008305"(integrin complex)|go:"GO:0009986"(cell surface)|go:"GO:0023035"(CD40 signaling pathway)|go:"GO:0030949"(positive regulation of vascular endothelial growth factor receptor signaling pathway)|go:"GO:0031589"(cell-substrate adhesion)|go:"GO:0033627"(cell adhesion mediated by integrin)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0034674"(integrin alpha5-beta1 complex)|go:"GO:0035313"(wound healing, spreading of epidermal cells)|go:"GO:0035987"(endodermal cell differentiation)|go:"GO:0043184"(vascular endothelial growth factor receptor 2 binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0071062"(alphav-beta3 integrin-vitronectin complex)|go:"GO:1903672"(positive regulation of sprouting angiogenesis)|go:"GO:2000811"(negative regulation of anoikis)|interpro:IPR000413(Integrins alpha chain)|interpro:IPR013517(FG-GAP)|interpro:IPR013519(Integrin alpha beta-propellor)|interpro:IPR013649(Integrin alpha-2)|interpro:IPR018184|interpro:IPR028994|interpro:IPR032695|mint:P08648|rcsb pdb:3VI3|rcsb pdb:3VI4|rcsb pdb:4WJK|rcsb pdb:4WK0|rcsb pdb:4WK2|rcsb pdb:4WK4|rcsb pdb:7NWL|reactome:R-HSA-1566948|reactome:R-HSA-1566977|reactome:R-HSA-202733|reactome:R-HSA-216083|reactome:R-HSA-445144|reactome:R-HSA-8941332|mint:MINT-8410744(identity)	-	-	-	comment:homomint|comment:mint|figure legend:F6A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9534(chlae-cos_7)|taxid:9534(Cercopithecus aethiops simian cells transformed with SV40)	-	2013/01/17	2014/10/16	rogid:rbevTt5rBnZGnKMpGArFIM0ZVUQ9606	rogid:Wv2ronpU6TmRP0kwlWisA2ObEbI9606	intact-crc:237EA61A1F041A8B|rigid:GwQ/Ljkeode148nfL6WJRtBK7iI	false	ha tag:?-?(MINT-8410741)	green fluorescent protein tag:?-?(MINT-8410745)	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P37023	uniprotkb:P08648	intact:EBI-8043559|uniprotkb:A6NGA8|intact:UNK-5840517|ensembl:ENSP00000373574	intact:EBI-1382311|uniprotkb:Q96HA5|ensembl:ENSP00000293379	psi-mi:acvl1_human(display_long)|uniprotkb:ACVRL1(gene name)|psi-mi:ACVRL1(display_short)|uniprotkb:ACVRLK1(gene name synonym)|uniprotkb:ALK1(gene name synonym)|uniprotkb:Activin receptor-like kinase 1(gene name synonym)|uniprotkb:TGF-B superfamily receptor type I(gene name synonym)	psi-mi:ita5_human(display_long)|uniprotkb:ITGA5(gene name)|psi-mi:ITGA5(display_short)|uniprotkb:FNRA(gene name synonym)|uniprotkb:Fibronectin receptor subunit alpha(gene name synonym)|uniprotkb:Integrin alpha-F(gene name synonym)|uniprotkb:VLA-5(gene name synonym)|uniprotkb:CD49 antigen-like family member E(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Tian et al. (2012)	pubmed:22940691|imex:IM-18764|mint:MINT-8410211	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8043553|mint:MINT-8410778|imex:IM-18764-9	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_005269292.1|refseq:NP_000011.2|refseq:NP_001070869.1|dip:DIP-5938N|ensembl:ENST00000388922(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001936"(regulation of endothelial cell proliferation)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0001946"(lymphangiogenesis)|go:"GO:0001955"(blood vessel maturation)|go:"GO:0001974"(blood vessel remodeling)|go:"GO:0002043"(blood vessel endothelial cell proliferation involved in sprouting angiogenesis)|go:"GO:0003203"(endocardial cushion morphogenesis)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004675"(transmembrane receptor protein serine/threonine kinase activity)|go:"GO:0005024"(transforming growth factor beta-activated receptor activity)|go:"GO:0005025"(transforming growth factor beta receptor activity, type I)|go:"GO:0005524"(ATP binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006468"(protein phosphorylation)|ensembl:ENSG00000139567(gene)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0071773"(cellular response to BMP stimulus)|go:"GO:0098821"(BMP receptor activity)|go:"GO:2000279"(negative regulation of DNA biosynthetic process)|interpro:IPR000333(Activin type II receptor)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR003605(TGF beta receptor, GS motif)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|rcsb pdb:2LCR|rcsb pdb:3MY0|rcsb pdb:4FAO|rcsb pdb:6SF1|rcsb pdb:6SF2|rcsb pdb:6SF3|reactome:R-HSA-201451|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007507"(heart development)|go:"GO:0008015"(blood circulation)|go:"GO:0008217"(regulation of blood pressure)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009953"(dorsal/ventral pattern formation)|go:"GO:0009986"(cell surface)|go:"GO:0010596"(negative regulation of endothelial cell migration)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0016361"(activin receptor activity, type I)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030425"(dendrite)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0030513"(positive regulation of BMP signaling pathway)|go:"GO:0032332"(positive regulation of chondrocyte differentiation)|go:"GO:0035313"(wound healing, spreading of epidermal cells)|go:"GO:0035912"(dorsal aorta morphogenesis)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043235"(receptor complex)|go:"GO:0043535"(regulation of blood vessel endothelial cell migration)|go:"GO:0043537"(negative regulation of blood vessel endothelial cell migration)|go:"GO:0045602"(negative regulation of endothelial cell differentiation)|go:"GO:0045603"(positive regulation of endothelial cell differentiation)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046332"(SMAD binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0048185"(activin binding)|go:"GO:0050431"(transforming growth factor beta binding)|go:"GO:0051895"(negative regulation of focal adhesion assembly)|go:"GO:0060836"(lymphatic endothelial cell differentiation)|go:"GO:0060840"(artery development)|go:"GO:0060841"(venous blood vessel development)|go:"GO:0061154"(endothelial tube morphogenesis)|go:"GO:0061298"(retina vasculature development in camera-type eye)|go:"GO:0070724"(BMP receptor complex)|go:"GO:0071363"(cellular response to growth factor stimulus)|mint:MINT-8410780(identity)	refseq:NP_002196.4|dip:DIP-40037N|ensembl:ENSG00000161638(gene)|ensembl:ENST00000293379(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001618"(virus receptor activity)|go:"GO:0001726"(ruffle)|go:"GO:0005161"(platelet-derived growth factor receptor binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0007155"(cell adhesion)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0008305"(integrin complex)|go:"GO:0009986"(cell surface)|go:"GO:0023035"(CD40 signaling pathway)|go:"GO:0030949"(positive regulation of vascular endothelial growth factor receptor signaling pathway)|go:"GO:0031589"(cell-substrate adhesion)|go:"GO:0033627"(cell adhesion mediated by integrin)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0034674"(integrin alpha5-beta1 complex)|go:"GO:0035313"(wound healing, spreading of epidermal cells)|go:"GO:0035987"(endodermal cell differentiation)|go:"GO:0043184"(vascular endothelial growth factor receptor 2 binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0071062"(alphav-beta3 integrin-vitronectin complex)|go:"GO:1903672"(positive regulation of sprouting angiogenesis)|go:"GO:2000811"(negative regulation of anoikis)|interpro:IPR000413(Integrins alpha chain)|interpro:IPR013517(FG-GAP)|interpro:IPR013519(Integrin alpha beta-propellor)|interpro:IPR013649(Integrin alpha-2)|interpro:IPR018184|interpro:IPR028994|interpro:IPR032695|mint:P08648|rcsb pdb:3VI3|rcsb pdb:3VI4|rcsb pdb:4WJK|rcsb pdb:4WK0|rcsb pdb:4WK2|rcsb pdb:4WK4|rcsb pdb:7NWL|reactome:R-HSA-1566948|reactome:R-HSA-1566977|reactome:R-HSA-202733|reactome:R-HSA-216083|reactome:R-HSA-445144|reactome:R-HSA-8941332|mint:MINT-8410784(identity)	-	function:On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for TGF-beta. May bind activin as well|comment:mint|comment:homomint|function:"Defects in ACVRL1 are the cause of hereditary hemorrhagic telangiectasia type 2 (HHT2) [MIM:600376]; also known as Osler-Rendu-Weber syndrome 2 (ORW2). HHT2 is an autosomal dominant multisystemic vascular dysplasia, characterized by recurrent epistaxis, muco-cutaneous telangiectases, gastro-intestinal hemorrhage, and pulmonary, cerebral and hepatic arteriovenous malformations; all secondary manifestations of the underlying vascular dysplasia"	-	comment:homomint|comment:mint|figure legend:F6A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9534(chlae-cos_7)|taxid:9534(Cercopithecus aethiops simian cells transformed with SV40)	-	2013/01/17	2014/10/16	rogid:0hUxx0V41Gm7SIQyaV3F/NoWiT49606	rogid:Wv2ronpU6TmRP0kwlWisA2ObEbI9606	intact-crc:8EF2EC9EC97988BE|rigid:VjPQUP3BfgdGcojy/yRhhDJO+aY	false	ha tag:?-?(MINT-8410781)	green fluorescent protein tag:?-?(MINT-8410785)	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P17813	uniprotkb:P32121	intact:EBI-2834630|uniprotkb:Q5T9C0|uniprotkb:Q14248|uniprotkb:Q14926|ensembl:ENSP00000362299	intact:EBI-714559|uniprotkb:Q0Z8D3|uniprotkb:Q2PP19|uniprotkb:Q6ICT3|uniprotkb:Q8N7Y2|uniprotkb:Q9UEQ6|uniprotkb:B7WPL3|uniprotkb:B5B0C0|uniprotkb:D3DTK2|intact:EBI-28974065|ensembl:ENSP00000269260|uniprotkb:B4DLW0|uniprotkb:H0Y688	psi-mi:egln_human(display_long)|uniprotkb:ENG(gene name)|psi-mi:ENG(display_short)|uniprotkb:END(gene name synonym)	psi-mi:arrb2_human(display_long)|uniprotkb:Arrestin beta-2(gene name synonym)|uniprotkb:ARRB2(gene name)|psi-mi:ARRB2(display_short)|uniprotkb:ARB2(gene name synonym)|uniprotkb:ARR2(gene name synonym)|uniprotkb:Non-visual arrestin-3(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Tian et al. (2012)	pubmed:22940691|imex:IM-18764|mint:MINT-8410211	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8043658|mint:MINT-8410792|imex:IM-18764-10	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0007155"(cell adhesion)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0015026"(coreceptor activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016477"(cell migration)|go:"GO:0016604"(nuclear body)|go:"GO:0017015"(regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0022009"(central nervous system vasculogenesis)|go:"GO:0022617"(extracellular matrix disassembly)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0005539"(glycosaminoglycan binding)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030513"(positive regulation of BMP signaling pathway)|go:"GO:0031953"(negative regulation of protein autophosphorylation)|go:"GO:0031960"(response to corticosteroid)|go:"GO:0032967"(positive regulation of collagen biosynthetic process)|go:"GO:0034713"(type I transforming growth factor beta receptor binding)|go:"GO:0035912"(dorsal aorta morphogenesis)|go:"GO:0042060"(wound healing)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042325"(regulation of phosphorylation)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043235"(receptor complex)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048185"(activin binding)|go:"GO:0048745"(smooth muscle tissue development)|go:"GO:0048844"(artery morphogenesis)|go:"GO:0048845"(venous blood vessel morphogenesis)|go:"GO:0048870"(cell motility)|go:"GO:0050431"(transforming growth factor beta binding)|go:"GO:0051001"(negative regulation of nitric-oxide synthase activity)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0055009"(atrial cardiac muscle tissue morphogenesis)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060348"(bone development)|go:"GO:0060394"(negative regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0070278"(extracellular matrix constituent secretion)|go:"GO:0070483"(detection of hypoxia)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0072563"(endothelial microparticle)|go:"GO:0097084"(vascular associated smooth muscle cell development)|go:"GO:1905007"(positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation)|go:"GO:1905065"(positive regulation of vascular associated smooth muscle cell differentiation)|go:"GO:1905222"(atrioventricular canal morphogenesis)|interpro:IPR001507(Endoglin/CD105 antigen)|mint:P17813|rcsb pdb:5HZV|rcsb pdb:5HZW|rcsb pdb:5I04|ensembl:ENSG00000106991(gene)|ensembl:ENST00000373203(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001525"(angiogenesis)|go:"GO:0001569"(branching involved in blood vessel morphogenesis)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0001947"(heart looping)|go:"GO:0003084"(positive regulation of systemic arterial blood pressure)|go:"GO:0003148"(outflow tract septum morphogenesis)|go:"GO:0003198"(epithelial to mesenchymal transition involved in endocardial cushion formation)|go:"GO:0003203"(endocardial cushion morphogenesis)|go:"GO:0003208"(cardiac ventricle morphogenesis)|go:"GO:0003209"(cardiac atrium morphogenesis)|go:"GO:0003222"(ventricular trabecula myocardium morphogenesis)|go:"GO:0003273"(cell migration involved in endocardial cushion formation)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005024"(transforming growth factor beta-activated receptor activity)|go:"GO:0005114"(type II transforming growth factor beta receptor binding)|go:"GO:0005534"(galactose binding)|go:"GO:0001570"(vasculogenesis)|refseq:NP_000109.1|refseq:NP_001108225.1|refseq:NP_001265067.1|dip:DIP-6246N|mint:MINT-8410798(identity)	ensembl:ENSP00000269260|ensembl:ENST00000346341|ensembl:ENSP00000341895|ensembl:ENST00000381488|ensembl:ENSP00000370898|ensembl:ENST00000412477|ensembl:ENSP00000403701|ensembl:ENSG00000141480(gene)|ensembl:ENST00000269260(transcript)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0002031"(G protein-coupled receptor internalization)|go:"GO:0002032"(desensitization of G protein-coupled receptor signaling pathway by arrestin)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0005102"(signaling receptor binding)|interpro:IPR017864|go:"GO:0005634"(nucleus)|mint:P32121|reactome:R-HSA-2122948|reactome:R-HSA-418555|reactome:R-HSA-456926|reactome:R-HSA-5099900|reactome:R-HSA-5635838|reactome:R-HSA-5674135|reactome:R-HSA-5689880|reactome:R-HSA-6802946|reactome:R-HSA-6802948|reactome:R-HSA-6802952|reactome:R-HSA-6802955|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-9649948|reactome:R-HSA-9656223|interpro:IPR014756(Immunoglobulin E-set)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019899"(enzyme binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031623"(receptor internalization)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031691"(alpha-1A adrenergic receptor binding)|go:"GO:0031692"(alpha-1B adrenergic receptor binding)|go:"GO:0031701"(angiotensin receptor binding)|go:"GO:0031702"(type 1 angiotensin receptor binding)|go:"GO:0031748"(D1 dopamine receptor binding)|go:"GO:0031762"(follicle-stimulating hormone receptor binding)|go:"GO:0031826"(type 2A serotonin receptor binding)|go:"GO:0031859"(platelet activating factor receptor binding)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032226"(positive regulation of synaptic transmission, dopaminergic)|go:"GO:0032691"(negative regulation of interleukin-1 beta production)|go:"GO:0032695"(negative regulation of interleukin-12 production)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032967"(positive regulation of collagen biosynthetic process)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034122"(negative regulation of toll-like receptor signaling pathway)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0034392"(negative regulation of smooth muscle cell apoptotic process)|go:"GO:0042699"(follicle-stimulating hormone signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0005829"(cytosol)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043197"(dendritic spine)|go:"GO:0043422"(protein kinase B binding)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045953"(negative regulation of natural killer cell mediated cytotoxicity)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050965"(detection of temperature stimulus involved in sensory perception of pain)|go:"GO:0005886"(plasma membrane)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0051928"(positive regulation of calcium ion transport)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071889"(14-3-3 protein binding)|go:"GO:0090201"(negative regulation of release of cytochrome c from mitochondria)|go:"GO:1904037"(positive regulation of epithelial cell apoptotic process)|go:"GO:1990763"(arrestin family protein binding)|go:"GO:2000573"(positive regulation of DNA biosynthetic process)|go:"GO:2000727"(positive regulation of cardiac muscle cell differentiation)|go:"GO:0007212"(dopamine receptor signaling pathway)|interpro:IPR000698(Arrestin)|interpro:IPR011021(Arrestin-like, N-terminal)|interpro:IPR011022(Arrestin-like, C-terminal)|go:"GO:0007420"(brain development)|interpro:IPR014752(Arrestin, C-terminal)|interpro:IPR014753(Arrestin, N-terminal)|go:"GO:0007628"(adult walking behavior)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015031"(protein transport)|refseq:NP_004304.1|refseq:NP_945355.1|refseq:NP_001316993.1|refseq:NP_001244259.1|refseq:NP_001244260.1|refseq:NP_001244257.1|refseq:NP_001244258.1|dip:DIP-40089N|mint:MINT-8410794(identity)	-	-	-	comment:homomint|comment:mint|figure legend:sf19|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9534(chlae-cos_7)|taxid:9534(Cercopithecus aethiops simian cells transformed with SV40)	-	2013/01/17	2014/10/16	rogid:6+7wUY8XztGVcjgbUlGaRjvBIK89606	rogid:MY34flMH9cdhPtMLGYOQtoQyr2U9606	intact-crc:9886AFDE12C778A8|rigid:yOdFcIetGZ14cOUjG8nDItLO2tw	false	mutation disrupting interaction:650-650(MINT-8410816)|ha tag:?-?(MINT-8410799)	flag tag:?-?(MINT-8410795)	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P17813	uniprotkb:P05556	intact:EBI-2834630|uniprotkb:Q5T9C0|uniprotkb:Q14248|uniprotkb:Q14926|ensembl:ENSP00000362299	intact:EBI-703066|intact:EBI-4289597|ensembl:ENSP00000303351|ensembl:ENSP00000379350|ensembl:ENSP00000398029|ensembl:ENSP00000404546|ensembl:ENSP00000502882|ensembl:ENSP00000503546|ensembl:ENSP00000503916|ensembl:ENSP00000504205|ensembl:ENSP00000504444|uniprotkb:Q7Z3V1|uniprotkb:Q8WUM6|uniprotkb:P78466|uniprotkb:P78467|uniprotkb:Q13089|uniprotkb:Q13090|uniprotkb:Q13091|uniprotkb:Q13212|uniprotkb:Q14622|uniprotkb:Q14647|uniprotkb:A8K6N2|uniprotkb:Q29RW2|uniprotkb:D3DRX9|uniprotkb:D3DRY3|uniprotkb:D3DRY4|uniprotkb:D3DRY5	psi-mi:egln_human(display_long)|uniprotkb:ENG(gene name)|psi-mi:ENG(display_short)|uniprotkb:END(gene name synonym)	psi-mi:itb1_human(display_long)|uniprotkb:Fibronectin receptor subunit beta(gene name synonym)|uniprotkb:VLA-4 subunit beta(gene name synonym)|uniprotkb:ITGB1(gene name)|psi-mi:ITGB1(display_short)|uniprotkb:FNRB(gene name synonym)|uniprotkb:MDF2(gene name synonym)|uniprotkb:MSK12(gene name synonym)|uniprotkb:Glycoprotein IIa(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Tian et al. (2012)	pubmed:22940691|imex:IM-18764|mint:MINT-8410211	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8043688|mint:MINT-8415241|imex:IM-18764-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0007155"(cell adhesion)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0015026"(coreceptor activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016477"(cell migration)|go:"GO:0016604"(nuclear body)|go:"GO:0017015"(regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0022009"(central nervous system vasculogenesis)|go:"GO:0022617"(extracellular matrix disassembly)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0005539"(glycosaminoglycan binding)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030513"(positive regulation of BMP signaling pathway)|go:"GO:0031953"(negative regulation of protein autophosphorylation)|go:"GO:0031960"(response to corticosteroid)|go:"GO:0032967"(positive regulation of collagen biosynthetic process)|go:"GO:0034713"(type I transforming growth factor beta receptor binding)|go:"GO:0035912"(dorsal aorta morphogenesis)|go:"GO:0042060"(wound healing)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042325"(regulation of phosphorylation)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043235"(receptor complex)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048185"(activin binding)|go:"GO:0048745"(smooth muscle tissue development)|go:"GO:0048844"(artery morphogenesis)|go:"GO:0048845"(venous blood vessel morphogenesis)|go:"GO:0048870"(cell motility)|go:"GO:0050431"(transforming growth factor beta binding)|go:"GO:0051001"(negative regulation of nitric-oxide synthase activity)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0055009"(atrial cardiac muscle tissue morphogenesis)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060348"(bone development)|go:"GO:0060394"(negative regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0070278"(extracellular matrix constituent secretion)|go:"GO:0070483"(detection of hypoxia)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0072563"(endothelial microparticle)|go:"GO:0097084"(vascular associated smooth muscle cell development)|go:"GO:1905007"(positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation)|go:"GO:1905065"(positive regulation of vascular associated smooth muscle cell differentiation)|go:"GO:1905222"(atrioventricular canal morphogenesis)|interpro:IPR001507(Endoglin/CD105 antigen)|mint:P17813|rcsb pdb:5HZV|rcsb pdb:5HZW|rcsb pdb:5I04|ensembl:ENSG00000106991(gene)|ensembl:ENST00000373203(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001525"(angiogenesis)|go:"GO:0001569"(branching involved in blood vessel morphogenesis)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0001947"(heart looping)|go:"GO:0003084"(positive regulation of systemic arterial blood pressure)|go:"GO:0003148"(outflow tract septum morphogenesis)|go:"GO:0003198"(epithelial to mesenchymal transition involved in endocardial cushion formation)|go:"GO:0003203"(endocardial cushion morphogenesis)|go:"GO:0003208"(cardiac ventricle morphogenesis)|go:"GO:0003209"(cardiac atrium morphogenesis)|go:"GO:0003222"(ventricular trabecula myocardium morphogenesis)|go:"GO:0003273"(cell migration involved in endocardial cushion formation)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005024"(transforming growth factor beta-activated receptor activity)|go:"GO:0005114"(type II transforming growth factor beta receptor binding)|go:"GO:0005534"(galactose binding)|go:"GO:0001570"(vasculogenesis)|refseq:NP_000109.1|refseq:NP_001108225.1|refseq:NP_001265067.1|dip:DIP-6246N|mint:MINT-8415247(identity)	go:"GO:0001618"(virus receptor activity)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001708"(cell fate specification)|go:"GO:0001726"(ruffle)|go:"GO:0001968"(fibronectin binding)|go:"GO:0002020"(protease binding)|go:"GO:0002042"(cell migration involved in sprouting angiogenesis)|go:"GO:0003779"(actin binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006909"(phagocytosis)|go:"GO:0006968"(cellular defense response)|go:"GO:0007155"(cell adhesion)|go:"GO:0007156"(homophilic cell adhesion via plasma membrane adhesion molecules)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007161"(calcium-independent cell-matrix adhesion)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008354"(germ cell migration)|go:"GO:0008542"(visual learning)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010008"(endosome membrane)|go:"GO:0010710"(regulation of collagen catabolic process)|go:"GO:0010763"(positive regulation of fibroblast migration)|go:"GO:0014704"(intercalated disc)|go:"GO:0015026"(coreceptor activity)|go:"GO:0016020"(membrane)|go:"GO:0016477"(cell migration)|go:"GO:0021943"(formation of radial glial scaffolds)|go:"GO:0023035"(CD40 signaling pathway)|go:"GO:0030027"(lamellipodium)|go:"GO:0030030"(cell projection organization)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0030175"(filopodium)|go:"GO:0030183"(B cell differentiation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031589"(cell-substrate adhesion)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031623"(receptor internalization)|go:"GO:0032154"(cleavage furrow)|go:"GO:0032587"(ruffle membrane)|go:"GO:0033627"(cell adhesion mediated by integrin)|go:"GO:0033631"(cell-cell adhesion mediated by integrin)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0034665"(integrin alpha1-beta1 complex)|go:"GO:0034666"(integrin alpha2-beta1 complex)|go:"GO:0034667"(integrin alpha3-beta1 complex)|go:"GO:0034668"(integrin alpha4-beta1 complex)|go:"GO:0034674"(integrin alpha5-beta1 complex)|go:"GO:0034677"(integrin alpha7-beta1 complex)|go:"GO:0034678"(integrin alpha8-beta1 complex)|go:"GO:0034680"(integrin alpha10-beta1 complex)|go:"GO:0034681"(integrin alpha11-beta1 complex)|go:"GO:0035024"(negative regulation of Rho protein signal transduction)|go:"GO:0035633"(maintenance of blood-brain barrier)|go:"GO:0035748"(myelin sheath abaxonal region)|go:"GO:0042383"(sarcolemma)|go:"GO:0042470"(melanosome)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043197"(dendritic spine)|go:"GO:0043235"(receptor complex)|go:"GO:0043236"(laminin binding)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045214"(sarcomere organization)|go:"GO:0045296"(cadherin binding)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0046872"(metal ion binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048333"(mesodermal cell differentiation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048675"(axon extension)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051951"(positive regulation of glutamate uptake involved in transmission of nerve impulse)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0055037"(recycling endosome)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071404"(cellular response to low-density lipoprotein particle stimulus)|go:"GO:0071711"(basement membrane organization)|go:"GO:0090303"(positive regulation of wound healing)|go:"GO:0097386"(glial cell projection)|go:"GO:0098639"(collagen binding involved in cell-matrix adhesion)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099699"(integral component of synaptic membrane)|go:"GO:0150003"(regulation of spontaneous synaptic transmission)|go:"GO:0150103"(reactive gliosis)|go:"GO:1901979"(regulation of inward rectifier potassium channel activity)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1990782"(protein tyrosine kinase binding)|go:"GO:2000273"(positive regulation of signaling receptor activity)|go:"GO:2000811"(negative regulation of anoikis)|interpro:IPR002369(Integrin beta subunit, N-terminal)|interpro:IPR012896(Integrin beta subunit, tail)|interpro:IPR013111(EGF, extracellular)|interpro:IPR014836(Integrin beta subunit, cytoplasmic)|interpro:IPR015812(Integrin beta subunit)|interpro:IPR016201(Plexin-like fold)|interpro:IPR027071|interpro:IPR032695|interpro:IPR033760|interpro:IPR036349|interpro:IPR036465|interpro:IPR040622|mint:P05556|rcsb pdb:1K11|rcsb pdb:1LHA|rcsb pdb:3G9W|rcsb pdb:3T9K|rcsb pdb:3VI3|rcsb pdb:3VI4|rcsb pdb:4DX9|rcsb pdb:4WJK|rcsb pdb:4WK0|rcsb pdb:4WK2|rcsb pdb:4WK4|rcsb pdb:7CEB|rcsb pdb:7CEC|rcsb pdb:7NWL|reactome:R-HSA-1566948|reactome:R-HSA-1566977|reactome:R-HSA-198933|ensembl:ENSG00000150093(gene)|ensembl:ENST00000302278(transcript)|ensembl:ENST00000396033(transcript)|ensembl:ENST00000417122(transcript)|ensembl:ENST00000437302(transcript)|ensembl:ENST00000677999(transcript)|ensembl:ENST00000678701(transcript)|ensembl:ENST00000678943(transcript)|ensembl:ENST00000678952(transcript)|ensembl:ENST00000678989(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0000132"(establishment of mitotic spindle orientation)|refseq:NP_002202.2|refseq:NP_391988.1|refseq:NP_596867.1|dip:DIP-312N|reactome:R-HSA-202733|reactome:R-HSA-210991|reactome:R-HSA-2129379|reactome:R-HSA-216083|reactome:R-HSA-3000157|reactome:R-HSA-3000170|reactome:R-HSA-3000178|reactome:R-HSA-416700|reactome:R-HSA-445144|reactome:R-HSA-446343|reactome:R-HSA-447041|reactome:R-HSA-5663220|reactome:R-HSA-6785807|reactome:R-HSA-75892|reactome:R-HSA-8874081|reactome:R-HSA-8875513|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013408|reactome:R-HSA-9013423|reactome:R-HSA-9609690|reactome:R-HSA-9679191|mint:MINT-8415243(identity)	-	-	-	figure legend:F5c|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9534(chlae-cos_7)|taxid:9534(Cercopithecus aethiops simian cells transformed with SV40)	-	2013/01/17	2014/10/16	rogid:6+7wUY8XztGVcjgbUlGaRjvBIK89606	rogid:FZ+lMRS6Zq07A8Lgmf5C6vEXUgM9606	intact-crc:A7EFE9C7D29F374B|rigid:+ijWHtj4x/JW7wiMJu1VFID1sFI	false	ha tag:?-?(MINT-8415248)	-	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P08648	uniprotkb:P17813	intact:EBI-1382311|uniprotkb:Q96HA5|ensembl:ENSP00000293379	intact:EBI-2834630|uniprotkb:Q5T9C0|uniprotkb:Q14248|uniprotkb:Q14926|ensembl:ENSP00000362299	psi-mi:ita5_human(display_long)|uniprotkb:ITGA5(gene name)|psi-mi:ITGA5(display_short)|uniprotkb:FNRA(gene name synonym)|uniprotkb:Fibronectin receptor subunit alpha(gene name synonym)|uniprotkb:Integrin alpha-F(gene name synonym)|uniprotkb:VLA-5(gene name synonym)|uniprotkb:CD49 antigen-like family member E(gene name synonym)	psi-mi:egln_human(display_long)|uniprotkb:ENG(gene name)|psi-mi:ENG(display_short)|uniprotkb:END(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Tian et al. (2012)	pubmed:22940691|imex:IM-18764|mint:MINT-8410211	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8043703|mint:MINT-8415254|imex:IM-18764-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002196.4|dip:DIP-40037N|ensembl:ENSG00000161638(gene)|ensembl:ENST00000293379(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001618"(virus receptor activity)|go:"GO:0001726"(ruffle)|go:"GO:0005161"(platelet-derived growth factor receptor binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0007155"(cell adhesion)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0008305"(integrin complex)|go:"GO:0009986"(cell surface)|go:"GO:0023035"(CD40 signaling pathway)|go:"GO:0030949"(positive regulation of vascular endothelial growth factor receptor signaling pathway)|go:"GO:0031589"(cell-substrate adhesion)|go:"GO:0033627"(cell adhesion mediated by integrin)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0034674"(integrin alpha5-beta1 complex)|go:"GO:0035313"(wound healing, spreading of epidermal cells)|go:"GO:0035987"(endodermal cell differentiation)|go:"GO:0043184"(vascular endothelial growth factor receptor 2 binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0071062"(alphav-beta3 integrin-vitronectin complex)|go:"GO:1903672"(positive regulation of sprouting angiogenesis)|go:"GO:2000811"(negative regulation of anoikis)|interpro:IPR000413(Integrins alpha chain)|interpro:IPR013517(FG-GAP)|interpro:IPR013519(Integrin alpha beta-propellor)|interpro:IPR013649(Integrin alpha-2)|interpro:IPR018184|interpro:IPR028994|interpro:IPR032695|mint:P08648|rcsb pdb:3VI3|rcsb pdb:3VI4|rcsb pdb:4WJK|rcsb pdb:4WK0|rcsb pdb:4WK2|rcsb pdb:4WK4|rcsb pdb:7NWL|reactome:R-HSA-1566948|reactome:R-HSA-1566977|reactome:R-HSA-202733|reactome:R-HSA-216083|reactome:R-HSA-445144|reactome:R-HSA-8941332|mint:MINT-8415260(identity)	go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0007155"(cell adhesion)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0015026"(coreceptor activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016477"(cell migration)|go:"GO:0016604"(nuclear body)|go:"GO:0017015"(regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0022009"(central nervous system vasculogenesis)|go:"GO:0022617"(extracellular matrix disassembly)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0005539"(glycosaminoglycan binding)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030513"(positive regulation of BMP signaling pathway)|go:"GO:0031953"(negative regulation of protein autophosphorylation)|go:"GO:0031960"(response to corticosteroid)|go:"GO:0032967"(positive regulation of collagen biosynthetic process)|go:"GO:0034713"(type I transforming growth factor beta receptor binding)|go:"GO:0035912"(dorsal aorta morphogenesis)|go:"GO:0042060"(wound healing)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042325"(regulation of phosphorylation)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043235"(receptor complex)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048185"(activin binding)|go:"GO:0048745"(smooth muscle tissue development)|go:"GO:0048844"(artery morphogenesis)|go:"GO:0048845"(venous blood vessel morphogenesis)|go:"GO:0048870"(cell motility)|go:"GO:0050431"(transforming growth factor beta binding)|go:"GO:0051001"(negative regulation of nitric-oxide synthase activity)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0055009"(atrial cardiac muscle tissue morphogenesis)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060348"(bone development)|go:"GO:0060394"(negative regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0070278"(extracellular matrix constituent secretion)|go:"GO:0070483"(detection of hypoxia)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0072563"(endothelial microparticle)|go:"GO:0097084"(vascular associated smooth muscle cell development)|go:"GO:1905007"(positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation)|go:"GO:1905065"(positive regulation of vascular associated smooth muscle cell differentiation)|go:"GO:1905222"(atrioventricular canal morphogenesis)|interpro:IPR001507(Endoglin/CD105 antigen)|mint:P17813|rcsb pdb:5HZV|rcsb pdb:5HZW|rcsb pdb:5I04|ensembl:ENSG00000106991(gene)|ensembl:ENST00000373203(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001525"(angiogenesis)|go:"GO:0001569"(branching involved in blood vessel morphogenesis)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0001947"(heart looping)|go:"GO:0003084"(positive regulation of systemic arterial blood pressure)|go:"GO:0003148"(outflow tract septum morphogenesis)|go:"GO:0003198"(epithelial to mesenchymal transition involved in endocardial cushion formation)|go:"GO:0003203"(endocardial cushion morphogenesis)|go:"GO:0003208"(cardiac ventricle morphogenesis)|go:"GO:0003209"(cardiac atrium morphogenesis)|go:"GO:0003222"(ventricular trabecula myocardium morphogenesis)|go:"GO:0003273"(cell migration involved in endocardial cushion formation)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005024"(transforming growth factor beta-activated receptor activity)|go:"GO:0005114"(type II transforming growth factor beta receptor binding)|go:"GO:0005534"(galactose binding)|go:"GO:0001570"(vasculogenesis)|refseq:NP_000109.1|refseq:NP_001108225.1|refseq:NP_001265067.1|dip:DIP-6246N|mint:MINT-8415256(identity)	-	-	-	figure legend:F5c|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9534(chlae-cos_7)|taxid:9534(Cercopithecus aethiops simian cells transformed with SV40)	-	2013/01/17	2014/10/16	rogid:Wv2ronpU6TmRP0kwlWisA2ObEbI9606	rogid:6+7wUY8XztGVcjgbUlGaRjvBIK89606	intact-crc:E70BBCA6B7BF2A04|rigid:Jq+iC4MvGy6GcghhlpMpen1SWiE	false	green fluorescent protein tag:?-?(MINT-8415261)	ha tag:?-?(MINT-8415257)	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P17813	uniprotkb:P08648	intact:EBI-2834630|uniprotkb:Q5T9C0|uniprotkb:Q14248|uniprotkb:Q14926|ensembl:ENSP00000362299	intact:EBI-1382311|uniprotkb:Q96HA5|ensembl:ENSP00000293379	psi-mi:egln_human(display_long)|uniprotkb:ENG(gene name)|psi-mi:ENG(display_short)|uniprotkb:END(gene name synonym)	psi-mi:ita5_human(display_long)|uniprotkb:ITGA5(gene name)|psi-mi:ITGA5(display_short)|uniprotkb:FNRA(gene name synonym)|uniprotkb:Fibronectin receptor subunit alpha(gene name synonym)|uniprotkb:Integrin alpha-F(gene name synonym)|uniprotkb:VLA-5(gene name synonym)|uniprotkb:CD49 antigen-like family member E(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Tian et al. (2012)	pubmed:22940691|imex:IM-18764|mint:MINT-8410211	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8043738|mint:MINT-8415270|imex:IM-18764-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0007155"(cell adhesion)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0015026"(coreceptor activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016477"(cell migration)|go:"GO:0016604"(nuclear body)|go:"GO:0017015"(regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0022009"(central nervous system vasculogenesis)|go:"GO:0022617"(extracellular matrix disassembly)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0005539"(glycosaminoglycan binding)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030513"(positive regulation of BMP signaling pathway)|go:"GO:0031953"(negative regulation of protein autophosphorylation)|go:"GO:0031960"(response to corticosteroid)|go:"GO:0032967"(positive regulation of collagen biosynthetic process)|go:"GO:0034713"(type I transforming growth factor beta receptor binding)|go:"GO:0035912"(dorsal aorta morphogenesis)|go:"GO:0042060"(wound healing)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042325"(regulation of phosphorylation)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043235"(receptor complex)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048185"(activin binding)|go:"GO:0048745"(smooth muscle tissue development)|go:"GO:0048844"(artery morphogenesis)|go:"GO:0048845"(venous blood vessel morphogenesis)|go:"GO:0048870"(cell motility)|go:"GO:0050431"(transforming growth factor beta binding)|go:"GO:0051001"(negative regulation of nitric-oxide synthase activity)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0055009"(atrial cardiac muscle tissue morphogenesis)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060348"(bone development)|go:"GO:0060394"(negative regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0070278"(extracellular matrix constituent secretion)|go:"GO:0070483"(detection of hypoxia)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0072563"(endothelial microparticle)|go:"GO:0097084"(vascular associated smooth muscle cell development)|go:"GO:1905007"(positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation)|go:"GO:1905065"(positive regulation of vascular associated smooth muscle cell differentiation)|go:"GO:1905222"(atrioventricular canal morphogenesis)|interpro:IPR001507(Endoglin/CD105 antigen)|mint:P17813|rcsb pdb:5HZV|rcsb pdb:5HZW|rcsb pdb:5I04|ensembl:ENSG00000106991(gene)|ensembl:ENST00000373203(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001525"(angiogenesis)|go:"GO:0001569"(branching involved in blood vessel morphogenesis)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0001947"(heart looping)|go:"GO:0003084"(positive regulation of systemic arterial blood pressure)|go:"GO:0003148"(outflow tract septum morphogenesis)|go:"GO:0003198"(epithelial to mesenchymal transition involved in endocardial cushion formation)|go:"GO:0003203"(endocardial cushion morphogenesis)|go:"GO:0003208"(cardiac ventricle morphogenesis)|go:"GO:0003209"(cardiac atrium morphogenesis)|go:"GO:0003222"(ventricular trabecula myocardium morphogenesis)|go:"GO:0003273"(cell migration involved in endocardial cushion formation)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005024"(transforming growth factor beta-activated receptor activity)|go:"GO:0005114"(type II transforming growth factor beta receptor binding)|go:"GO:0005534"(galactose binding)|go:"GO:0001570"(vasculogenesis)|refseq:NP_000109.1|refseq:NP_001108225.1|refseq:NP_001265067.1|dip:DIP-6246N|mint:MINT-8415276(identity)	refseq:NP_002196.4|dip:DIP-40037N|ensembl:ENSG00000161638(gene)|ensembl:ENST00000293379(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001618"(virus receptor activity)|go:"GO:0001726"(ruffle)|go:"GO:0005161"(platelet-derived growth factor receptor binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0007155"(cell adhesion)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0008305"(integrin complex)|go:"GO:0009986"(cell surface)|go:"GO:0023035"(CD40 signaling pathway)|go:"GO:0030949"(positive regulation of vascular endothelial growth factor receptor signaling pathway)|go:"GO:0031589"(cell-substrate adhesion)|go:"GO:0033627"(cell adhesion mediated by integrin)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0034674"(integrin alpha5-beta1 complex)|go:"GO:0035313"(wound healing, spreading of epidermal cells)|go:"GO:0035987"(endodermal cell differentiation)|go:"GO:0043184"(vascular endothelial growth factor receptor 2 binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0071062"(alphav-beta3 integrin-vitronectin complex)|go:"GO:1903672"(positive regulation of sprouting angiogenesis)|go:"GO:2000811"(negative regulation of anoikis)|interpro:IPR000413(Integrins alpha chain)|interpro:IPR013517(FG-GAP)|interpro:IPR013519(Integrin alpha beta-propellor)|interpro:IPR013649(Integrin alpha-2)|interpro:IPR018184|interpro:IPR028994|interpro:IPR032695|mint:P08648|rcsb pdb:3VI3|rcsb pdb:3VI4|rcsb pdb:4WJK|rcsb pdb:4WK0|rcsb pdb:4WK2|rcsb pdb:4WK4|rcsb pdb:7NWL|reactome:R-HSA-1566948|reactome:R-HSA-1566977|reactome:R-HSA-202733|reactome:R-HSA-216083|reactome:R-HSA-445144|reactome:R-HSA-8941332|mint:MINT-8415272(identity)	-	-	-	comment:homomint|comment:mint|figure legend:F5a|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9534(chlae-cos_7)|taxid:9534(Cercopithecus aethiops simian cells transformed with SV40)	-	2013/01/17	2014/10/16	rogid:6+7wUY8XztGVcjgbUlGaRjvBIK89606	rogid:Wv2ronpU6TmRP0kwlWisA2ObEbI9606	intact-crc:0A642A07437A9CA2|rigid:Jq+iC4MvGy6GcghhlpMpen1SWiE	false	ha tag:?-?(MINT-8415277)	green fluorescent protein tag:?-?(MINT-8415273)	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P17813	uniprotkb:P08648	intact:EBI-2834630|uniprotkb:Q5T9C0|uniprotkb:Q14248|uniprotkb:Q14926|ensembl:ENSP00000362299	intact:EBI-1382311|uniprotkb:Q96HA5|ensembl:ENSP00000293379	psi-mi:egln_human(display_long)|uniprotkb:ENG(gene name)|psi-mi:ENG(display_short)|uniprotkb:END(gene name synonym)	psi-mi:ita5_human(display_long)|uniprotkb:ITGA5(gene name)|psi-mi:ITGA5(display_short)|uniprotkb:FNRA(gene name synonym)|uniprotkb:Fibronectin receptor subunit alpha(gene name synonym)|uniprotkb:Integrin alpha-F(gene name synonym)|uniprotkb:VLA-5(gene name synonym)|uniprotkb:CD49 antigen-like family member E(gene name synonym)	psi-mi:"MI:0416"(fluorescence microscopy)	Tian et al. (2012)	pubmed:22940691|imex:IM-18764|mint:MINT-8410211	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0471"(MINT)	intact:EBI-8043764|mint:MINT-8415288|imex:IM-18764-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0007155"(cell adhesion)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0015026"(coreceptor activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016477"(cell migration)|go:"GO:0016604"(nuclear body)|go:"GO:0017015"(regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0022009"(central nervous system vasculogenesis)|go:"GO:0022617"(extracellular matrix disassembly)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0005539"(glycosaminoglycan binding)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030513"(positive regulation of BMP signaling pathway)|go:"GO:0031953"(negative regulation of protein autophosphorylation)|go:"GO:0031960"(response to corticosteroid)|go:"GO:0032967"(positive regulation of collagen biosynthetic process)|go:"GO:0034713"(type I transforming growth factor beta receptor binding)|go:"GO:0035912"(dorsal aorta morphogenesis)|go:"GO:0042060"(wound healing)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042325"(regulation of phosphorylation)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043235"(receptor complex)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048185"(activin binding)|go:"GO:0048745"(smooth muscle tissue development)|go:"GO:0048844"(artery morphogenesis)|go:"GO:0048845"(venous blood vessel morphogenesis)|go:"GO:0048870"(cell motility)|go:"GO:0050431"(transforming growth factor beta binding)|go:"GO:0051001"(negative regulation of nitric-oxide synthase activity)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0055009"(atrial cardiac muscle tissue morphogenesis)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060348"(bone development)|go:"GO:0060394"(negative regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0070278"(extracellular matrix constituent secretion)|go:"GO:0070483"(detection of hypoxia)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0072563"(endothelial microparticle)|go:"GO:0097084"(vascular associated smooth muscle cell development)|go:"GO:1905007"(positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation)|go:"GO:1905065"(positive regulation of vascular associated smooth muscle cell differentiation)|go:"GO:1905222"(atrioventricular canal morphogenesis)|interpro:IPR001507(Endoglin/CD105 antigen)|mint:P17813|rcsb pdb:5HZV|rcsb pdb:5HZW|rcsb pdb:5I04|ensembl:ENSG00000106991(gene)|ensembl:ENST00000373203(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001525"(angiogenesis)|go:"GO:0001569"(branching involved in blood vessel morphogenesis)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0001947"(heart looping)|go:"GO:0003084"(positive regulation of systemic arterial blood pressure)|go:"GO:0003148"(outflow tract septum morphogenesis)|go:"GO:0003198"(epithelial to mesenchymal transition involved in endocardial cushion formation)|go:"GO:0003203"(endocardial cushion morphogenesis)|go:"GO:0003208"(cardiac ventricle morphogenesis)|go:"GO:0003209"(cardiac atrium morphogenesis)|go:"GO:0003222"(ventricular trabecula myocardium morphogenesis)|go:"GO:0003273"(cell migration involved in endocardial cushion formation)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005024"(transforming growth factor beta-activated receptor activity)|go:"GO:0005114"(type II transforming growth factor beta receptor binding)|go:"GO:0005534"(galactose binding)|go:"GO:0001570"(vasculogenesis)|refseq:NP_000109.1|refseq:NP_001108225.1|refseq:NP_001265067.1|dip:DIP-6246N|mint:MINT-8415290(identity)	refseq:NP_002196.4|dip:DIP-40037N|ensembl:ENSG00000161638(gene)|ensembl:ENST00000293379(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001618"(virus receptor activity)|go:"GO:0001726"(ruffle)|go:"GO:0005161"(platelet-derived growth factor receptor binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0007155"(cell adhesion)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0008305"(integrin complex)|go:"GO:0009986"(cell surface)|go:"GO:0023035"(CD40 signaling pathway)|go:"GO:0030949"(positive regulation of vascular endothelial growth factor receptor signaling pathway)|go:"GO:0031589"(cell-substrate adhesion)|go:"GO:0033627"(cell adhesion mediated by integrin)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0034674"(integrin alpha5-beta1 complex)|go:"GO:0035313"(wound healing, spreading of epidermal cells)|go:"GO:0035987"(endodermal cell differentiation)|go:"GO:0043184"(vascular endothelial growth factor receptor 2 binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0071062"(alphav-beta3 integrin-vitronectin complex)|go:"GO:1903672"(positive regulation of sprouting angiogenesis)|go:"GO:2000811"(negative regulation of anoikis)|interpro:IPR000413(Integrins alpha chain)|interpro:IPR013517(FG-GAP)|interpro:IPR013519(Integrin alpha beta-propellor)|interpro:IPR013649(Integrin alpha-2)|interpro:IPR018184|interpro:IPR028994|interpro:IPR032695|mint:P08648|rcsb pdb:3VI3|rcsb pdb:3VI4|rcsb pdb:4WJK|rcsb pdb:4WK0|rcsb pdb:4WK2|rcsb pdb:4WK4|rcsb pdb:7NWL|reactome:R-HSA-1566948|reactome:R-HSA-1566977|reactome:R-HSA-202733|reactome:R-HSA-216083|reactome:R-HSA-445144|reactome:R-HSA-8941332|mint:MINT-8415294(identity)	go:"GO:0005768"(endosome)	-	-	comment:homomint|comment:mint|figure legend:F7a f7b|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-meec)|taxid:10090(Mus musculus)	-	2013/01/17	2014/10/16	rogid:6+7wUY8XztGVcjgbUlGaRjvBIK89606	rogid:Wv2ronpU6TmRP0kwlWisA2ObEbI9606	intact-crc:CAB04F921C902DD0|rigid:Jq+iC4MvGy6GcghhlpMpen1SWiE	false	ha tag:?-?(MINT-8415291)	green fluorescent protein tag:?-?(MINT-8415302)	-	-	psi-mi:"MI:0422"(immunostaining)	psi-mi:"MI:0707"(anti tag immunostaining)