#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P46597	uniprotkb:P46597	intact:EBI-6502097|uniprotkb:B2RC33|uniprotkb:Q16598|uniprotkb:Q5JQ72|uniprotkb:Q5JQ73|ensembl:ENSP00000370627	intact:EBI-6502097|uniprotkb:B2RC33|uniprotkb:Q16598|uniprotkb:Q5JQ72|uniprotkb:Q5JQ73|ensembl:ENSP00000370627	psi-mi:asmt_human(display_long)|uniprotkb:ASMT(gene name)|psi-mi:ASMT(display_short)|uniprotkb:Hydroxyindole O-methyltransferase(gene name synonym)	psi-mi:asmt_human(display_long)|uniprotkb:ASMT(gene name)|psi-mi:ASMT(display_short)|uniprotkb:Hydroxyindole O-methyltransferase(gene name synonym)	psi-mi:"MI:0114"(x-ray crystallography)	Botros et al. (2012)	imex:IM-18645|pubmed:22775292	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0486"(UniProt)	intact:EBI-6502096|pdbe:4A6D|imex:IM-18645-1|pdbe:4A6E	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001164509.1|refseq:NP_001164510.1|refseq:NP_004034.2|ensembl:ENSG00000196433(gene)|ensembl:ENST00000381229(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0006412"(translation)|go:"GO:0008171"(O-methyltransferase activity)|go:"GO:0008172"(S-methyltransferase activity)|go:"GO:0008757"(S-adenosylmethionine-dependent methyltransferase activity)|go:"GO:0017096"(acetylserotonin O-methyltransferase activity)|go:"GO:0019438"(aromatic compound biosynthetic process)|go:"GO:0030187"(melatonin biosynthetic process)|go:"GO:0032259"(methylation)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0046219"(indolalkylamine biosynthetic process)|interpro:IPR001077(O-methyltransferase, family 2)|interpro:IPR016461(O-methyltransferase, COMT, eukaryota)|interpro:IPR029063|interpro:IPR031725|interpro:IPR036388|interpro:IPR036390|rcsb pdb:4A6D|rcsb pdb:4A6E|reactome:R-HSA-209931	refseq:NP_001164509.1|refseq:NP_001164510.1|refseq:NP_004034.2|ensembl:ENSG00000196433(gene)|ensembl:ENST00000381229(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0006412"(translation)|go:"GO:0008171"(O-methyltransferase activity)|go:"GO:0008172"(S-methyltransferase activity)|go:"GO:0008757"(S-adenosylmethionine-dependent methyltransferase activity)|go:"GO:0017096"(acetylserotonin O-methyltransferase activity)|go:"GO:0019438"(aromatic compound biosynthetic process)|go:"GO:0030187"(melatonin biosynthetic process)|go:"GO:0032259"(methylation)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0046219"(indolalkylamine biosynthetic process)|interpro:IPR001077(O-methyltransferase, family 2)|interpro:IPR016461(O-methyltransferase, COMT, eukaryota)|interpro:IPR029063|interpro:IPR031725|interpro:IPR036388|interpro:IPR036390|rcsb pdb:4A6D|rcsb pdb:4A6E|reactome:R-HSA-209931	-	-	-	3d-r-factors:"R-Value: 0.177 (obs.), R-Free: 0.204 for 4A6D, R-Value: 0.165 (obs.), R-Free: 0.212 for 4A6E"|3d-resolution:2.40 A for 4A6D  2.70 A for 4A6E|figure legend:Fig 1.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/01/23	2014/10/16	rogid:JKUzJpmSJu561hLvUj0E5syKOYs9606	rogid:JKUzJpmSJu561hLvUj0E5syKOYs9606	intact-crc:D28AC1B4F838F1B4|rigid:4KJnHEM7Ca2qoYm4PkmW+EptkQI	false	-	-	2	0	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P46597	uniprotkb:P46597	intact:EBI-6502097|uniprotkb:B2RC33|uniprotkb:Q16598|uniprotkb:Q5JQ72|uniprotkb:Q5JQ73|ensembl:ENSP00000370627	intact:EBI-6502097|uniprotkb:B2RC33|uniprotkb:Q16598|uniprotkb:Q5JQ72|uniprotkb:Q5JQ73|ensembl:ENSP00000370627	psi-mi:asmt_human(display_long)|uniprotkb:ASMT(gene name)|psi-mi:ASMT(display_short)|uniprotkb:Hydroxyindole O-methyltransferase(gene name synonym)	psi-mi:asmt_human(display_long)|uniprotkb:ASMT(gene name)|psi-mi:ASMT(display_short)|uniprotkb:Hydroxyindole O-methyltransferase(gene name synonym)	psi-mi:"MI:0071"(molecular sieving)	Botros et al. (2012)	imex:IM-18645|pubmed:22775292	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-6504707|imex:IM-18645-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001164509.1|refseq:NP_001164510.1|refseq:NP_004034.2|ensembl:ENSG00000196433(gene)|ensembl:ENST00000381229(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0006412"(translation)|go:"GO:0008171"(O-methyltransferase activity)|go:"GO:0008172"(S-methyltransferase activity)|go:"GO:0008757"(S-adenosylmethionine-dependent methyltransferase activity)|go:"GO:0017096"(acetylserotonin O-methyltransferase activity)|go:"GO:0019438"(aromatic compound biosynthetic process)|go:"GO:0030187"(melatonin biosynthetic process)|go:"GO:0032259"(methylation)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0046219"(indolalkylamine biosynthetic process)|interpro:IPR001077(O-methyltransferase, family 2)|interpro:IPR016461(O-methyltransferase, COMT, eukaryota)|interpro:IPR029063|interpro:IPR031725|interpro:IPR036388|interpro:IPR036390|rcsb pdb:4A6D|rcsb pdb:4A6E|reactome:R-HSA-209931	refseq:NP_001164509.1|refseq:NP_001164510.1|refseq:NP_004034.2|ensembl:ENSG00000196433(gene)|ensembl:ENST00000381229(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0006412"(translation)|go:"GO:0008171"(O-methyltransferase activity)|go:"GO:0008172"(S-methyltransferase activity)|go:"GO:0008757"(S-adenosylmethionine-dependent methyltransferase activity)|go:"GO:0017096"(acetylserotonin O-methyltransferase activity)|go:"GO:0019438"(aromatic compound biosynthetic process)|go:"GO:0030187"(melatonin biosynthetic process)|go:"GO:0032259"(methylation)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0046219"(indolalkylamine biosynthetic process)|interpro:IPR001077(O-methyltransferase, family 2)|interpro:IPR016461(O-methyltransferase, COMT, eukaryota)|interpro:IPR029063|interpro:IPR031725|interpro:IPR036388|interpro:IPR036390|rcsb pdb:4A6D|rcsb pdb:4A6E|reactome:R-HSA-209931	-	-	-	figure legend:Fig 2 b|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9534(chlae-cos_7)|taxid:9534(Cercopithecus aethiops simian cells transformed with SV40)	-	2013/01/23	2014/10/16	rogid:JKUzJpmSJu561hLvUj0E5syKOYs9606	rogid:JKUzJpmSJu561hLvUj0E5syKOYs9606	intact-crc:4B6FF729F57D01E7|rigid:4KJnHEM7Ca2qoYm4PkmW+EptkQI	false	-	-	2	0	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P46597	uniprotkb:P46597	intact:EBI-6502097|uniprotkb:B2RC33|uniprotkb:Q16598|uniprotkb:Q5JQ72|uniprotkb:Q5JQ73|ensembl:ENSP00000370627	intact:EBI-6502097|uniprotkb:B2RC33|uniprotkb:Q16598|uniprotkb:Q5JQ72|uniprotkb:Q5JQ73|ensembl:ENSP00000370627	psi-mi:asmt_human(display_long)|uniprotkb:ASMT(gene name)|psi-mi:ASMT(display_short)|uniprotkb:Hydroxyindole O-methyltransferase(gene name synonym)	psi-mi:asmt_human(display_long)|uniprotkb:ASMT(gene name)|psi-mi:ASMT(display_short)|uniprotkb:Hydroxyindole O-methyltransferase(gene name synonym)	psi-mi:"MI:0071"(molecular sieving)	Botros et al. (2012)	imex:IM-18645|pubmed:22775292	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0486"(UniProt)	intact:EBI-6502134|imex:IM-18645-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001164509.1|refseq:NP_001164510.1|refseq:NP_004034.2|ensembl:ENSG00000196433(gene)|ensembl:ENST00000381229(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0006412"(translation)|go:"GO:0008171"(O-methyltransferase activity)|go:"GO:0008172"(S-methyltransferase activity)|go:"GO:0008757"(S-adenosylmethionine-dependent methyltransferase activity)|go:"GO:0017096"(acetylserotonin O-methyltransferase activity)|go:"GO:0019438"(aromatic compound biosynthetic process)|go:"GO:0030187"(melatonin biosynthetic process)|go:"GO:0032259"(methylation)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0046219"(indolalkylamine biosynthetic process)|interpro:IPR001077(O-methyltransferase, family 2)|interpro:IPR016461(O-methyltransferase, COMT, eukaryota)|interpro:IPR029063|interpro:IPR031725|interpro:IPR036388|interpro:IPR036390|rcsb pdb:4A6D|rcsb pdb:4A6E|reactome:R-HSA-209931	refseq:NP_001164509.1|refseq:NP_001164510.1|refseq:NP_004034.2|ensembl:ENSG00000196433(gene)|ensembl:ENST00000381229(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0006412"(translation)|go:"GO:0008171"(O-methyltransferase activity)|go:"GO:0008172"(S-methyltransferase activity)|go:"GO:0008757"(S-adenosylmethionine-dependent methyltransferase activity)|go:"GO:0017096"(acetylserotonin O-methyltransferase activity)|go:"GO:0019438"(aromatic compound biosynthetic process)|go:"GO:0030187"(melatonin biosynthetic process)|go:"GO:0032259"(methylation)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0046219"(indolalkylamine biosynthetic process)|interpro:IPR001077(O-methyltransferase, family 2)|interpro:IPR016461(O-methyltransferase, COMT, eukaryota)|interpro:IPR029063|interpro:IPR031725|interpro:IPR036388|interpro:IPR036390|rcsb pdb:4A6D|rcsb pdb:4A6E|reactome:R-HSA-209931	-	-	-	figure legend:Fig 2 c|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-pineal_gland)|taxid:9606(Human pineal gland)	-	2013/01/23	2014/10/16	rogid:JKUzJpmSJu561hLvUj0E5syKOYs9606	rogid:JKUzJpmSJu561hLvUj0E5syKOYs9606	intact-crc:6C9E343E5D040CF8|rigid:4KJnHEM7Ca2qoYm4PkmW+EptkQI	false	-	-	2	0	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)