#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P24863	uniprotkb:P49336	intact:EBI-395261|uniprotkb:Q9H543|ensembl:ENSP00000428982|uniprotkb:B4DPZ1	intact:EBI-394377|uniprotkb:Q5VUF3|uniprotkb:Q6ISB5|ensembl:ENSP00000370938	psi-mi:ccnc_human(display_long)|uniprotkb:CCNC(gene name)|psi-mi:CCNC(display_short)|uniprotkb:SRB11 homolog(gene name synonym)	psi-mi:cdk8_human(display_long)|uniprotkb:CDK8(gene name)|psi-mi:CDK8(display_short)|uniprotkb:Cell division protein kinase 8(gene name synonym)|uniprotkb:Mediator of RNA polymerase II transcription subunit CDK8(gene name synonym)|uniprotkb:Mediator complex subunit CDK8(gene name synonym)|uniprotkb:Protein kinase K35(gene name synonym)	psi-mi:"MI:0114"(x-ray crystallography)	Schneider et al. (2011)	imex:IM-20937|pubmed:21806996	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6868066|imex:IM-20937-1|wwpdb:3RGF	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000112237(gene)|ensembl:ENST00000520429(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0016538"(cyclin-dependent protein serine/threonine kinase regulator activity)|go:"GO:0016592"(mediator complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|interpro:IPR006671(Cyclin, N-terminal)|interpro:IPR013763(Cyclin-related)|interpro:IPR028367|interpro:IPR036915|interpro:IPR043198|mint:P24863|rcsb pdb:5XQX|rcsb pdb:5XS2|rcsb pdb:6QTG|rcsb pdb:6QTJ|rcsb pdb:6R3S|rcsb pdb:6T41|rcsb pdb:6TPA|rcsb pdb:6Y0A|reactome:R-HSA-1989781|reactome:R-HSA-2122947|reactome:R-HSA-212436|reactome:R-HSA-2173796|reactome:R-HSA-2644606|reactome:R-HSA-2894862|reactome:R-HSA-381340|rcsb pdb:3RGF|rcsb pdb:4CRL|rcsb pdb:4F6S|rcsb pdb:4F6U|rcsb pdb:4F6W|rcsb pdb:4F70|rcsb pdb:4F7J|rcsb pdb:4F7L|rcsb pdb:4F7N|rcsb pdb:4F7S|rcsb pdb:4G6L|rcsb pdb:5BNJ|rcsb pdb:5CEI|rcsb pdb:5FGK|rcsb pdb:5HBE|rcsb pdb:5HBH|rcsb pdb:5HBJ|rcsb pdb:5HNB|rcsb pdb:5HVY|rcsb pdb:5I5Z|rcsb pdb:5ICP|rcsb pdb:5IDN|rcsb pdb:5IDP|refseq:NP_005181.2|refseq:NP_001013417.1|dip:DIP-32920N	refseq:NP_001305297.1|refseq:NP_001251.1|ensembl:ENSG00000132964(gene)|ensembl:ENST00000381527(transcript)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006468"(protein phosphorylation)|rcsb pdb:5FGK|go:"GO:0008353"(RNA polymerase II CTD heptapeptide repeat kinase activity)|go:"GO:0016592"(mediator complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P49336|rcsb pdb:3RGF|rcsb pdb:4CRL|rcsb pdb:4F6S|rcsb pdb:4F6U|rcsb pdb:4F6W|rcsb pdb:4F70|rcsb pdb:4F7J|rcsb pdb:4F7L|rcsb pdb:4F7N|rcsb pdb:4F7S|rcsb pdb:4G6L|rcsb pdb:5BNJ|rcsb pdb:5CEI|rcsb pdb:5HBE|rcsb pdb:5HBH|rcsb pdb:5HBJ|rcsb pdb:5HNB|rcsb pdb:5HVY|rcsb pdb:5I5Z|rcsb pdb:5ICP|rcsb pdb:5IDN|rcsb pdb:5IDP|rcsb pdb:5XQX|rcsb pdb:5XS2|rcsb pdb:6QTG|rcsb pdb:6QTJ|rcsb pdb:6R3S|rcsb pdb:6T41|rcsb pdb:6TPA|rcsb pdb:6Y0A|reactome:R-HSA-1989781|reactome:R-HSA-2122947|reactome:R-HSA-212436|reactome:R-HSA-2173796|reactome:R-HSA-2644606|reactome:R-HSA-2894862|reactome:R-HSA-381340|dip:DIP-32595N	-	-	-	figure legend:Fig. 1, Fig. 2b, Fig. 4, Fig. 5, Fig. 6, Fig. 8, Table 1|3d-resolution:2.20A|3d-r-factors:working 18.1%, free 22.1%|3d-structure:The inhibitor sorafenib, an anti-cancer drug, is bound to the CDK8 hinge region within the catalytic cleft between the two kinase lobes. Both CDK8 and CCNC contain two additional amino acid residues from the purification/expression tag upstream of the methionine residue in the first position of the native sequence.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/06/25	2014/10/16	rogid:Gu327q98H8ggQoYCb4UnR2Mcsyg9606	rogid:f+78iyCfA9osCQ82uY6reu3JKzo9606	intact-crc:A1A6BC5806D97380	false	-	sufficient binding region:1-403	1	1	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
chebi:"CHEBI:50924"	uniprotkb:P24863	intact:EBI-6868749	intact:EBI-395261|uniprotkb:Q9H543|ensembl:ENSP00000428982|uniprotkb:B4DPZ1	psi-mi:sorafenib(display_short)|psi-mi:"CHEBI:50924"(display_long)	psi-mi:ccnc_human(display_long)|uniprotkb:CCNC(gene name)|psi-mi:CCNC(display_short)|uniprotkb:SRB11 homolog(gene name synonym)	psi-mi:"MI:0114"(x-ray crystallography)	Schneider et al. (2011)	imex:IM-20937|pubmed:21806996	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6868066|imex:IM-20937-1|wwpdb:3RGF	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	ensembl:ENSG00000112237(gene)|ensembl:ENST00000520429(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0016538"(cyclin-dependent protein serine/threonine kinase regulator activity)|go:"GO:0016592"(mediator complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|interpro:IPR006671(Cyclin, N-terminal)|interpro:IPR013763(Cyclin-related)|interpro:IPR028367|interpro:IPR036915|interpro:IPR043198|mint:P24863|rcsb pdb:5XQX|rcsb pdb:5XS2|rcsb pdb:6QTG|rcsb pdb:6QTJ|rcsb pdb:6R3S|rcsb pdb:6T41|rcsb pdb:6TPA|rcsb pdb:6Y0A|reactome:R-HSA-1989781|reactome:R-HSA-2122947|reactome:R-HSA-212436|reactome:R-HSA-2173796|reactome:R-HSA-2644606|reactome:R-HSA-2894862|reactome:R-HSA-381340|rcsb pdb:3RGF|rcsb pdb:4CRL|rcsb pdb:4F6S|rcsb pdb:4F6U|rcsb pdb:4F6W|rcsb pdb:4F70|rcsb pdb:4F7J|rcsb pdb:4F7L|rcsb pdb:4F7N|rcsb pdb:4F7S|rcsb pdb:4G6L|rcsb pdb:5BNJ|rcsb pdb:5CEI|rcsb pdb:5FGK|rcsb pdb:5HBE|rcsb pdb:5HBH|rcsb pdb:5HBJ|rcsb pdb:5HNB|rcsb pdb:5HVY|rcsb pdb:5I5Z|rcsb pdb:5ICP|rcsb pdb:5IDN|rcsb pdb:5IDP|refseq:NP_005181.2|refseq:NP_001013417.1|dip:DIP-32920N	-	-	-	figure legend:Fig. 1, Fig. 2b, Fig. 4, Fig. 5, Fig. 6, Fig. 8, Table 1|3d-resolution:2.20A|3d-r-factors:working 18.1%, free 22.1%|3d-structure:The inhibitor sorafenib, an anti-cancer drug, is bound to the CDK8 hinge region within the catalytic cleft between the two kinase lobes. Both CDK8 and CCNC contain two additional amino acid residues from the purification/expression tag upstream of the methionine residue in the first position of the native sequence.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/06/25	2014/10/16	-	rogid:Gu327q98H8ggQoYCb4UnR2Mcsyg9606	intact-crc:A1A6BC5806D97380	false	-	-	1	1	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P49336	uniprotkb:P24863	intact:EBI-394377|uniprotkb:Q5VUF3|uniprotkb:Q6ISB5|ensembl:ENSP00000370938	intact:EBI-395261|uniprotkb:Q9H543|ensembl:ENSP00000428982|uniprotkb:B4DPZ1	psi-mi:cdk8_human(display_long)|uniprotkb:CDK8(gene name)|psi-mi:CDK8(display_short)|uniprotkb:Cell division protein kinase 8(gene name synonym)|uniprotkb:Mediator of RNA polymerase II transcription subunit CDK8(gene name synonym)|uniprotkb:Mediator complex subunit CDK8(gene name synonym)|uniprotkb:Protein kinase K35(gene name synonym)	psi-mi:ccnc_human(display_long)|uniprotkb:CCNC(gene name)|psi-mi:CCNC(display_short)|uniprotkb:SRB11 homolog(gene name synonym)	psi-mi:"MI:0055"(fluorescent resonance energy transfer)	Schneider et al. (2011)	imex:IM-20937|pubmed:21806996	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-6868129|imex:IM-20937-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0583"(fluorescence donor)	psi-mi:"MI:0584"(fluorescence acceptor)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001305297.1|refseq:NP_001251.1|ensembl:ENSG00000132964(gene)|ensembl:ENST00000381527(transcript)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006468"(protein phosphorylation)|rcsb pdb:5FGK|go:"GO:0008353"(RNA polymerase II CTD heptapeptide repeat kinase activity)|go:"GO:0016592"(mediator complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P49336|rcsb pdb:3RGF|rcsb pdb:4CRL|rcsb pdb:4F6S|rcsb pdb:4F6U|rcsb pdb:4F6W|rcsb pdb:4F70|rcsb pdb:4F7J|rcsb pdb:4F7L|rcsb pdb:4F7N|rcsb pdb:4F7S|rcsb pdb:4G6L|rcsb pdb:5BNJ|rcsb pdb:5CEI|rcsb pdb:5HBE|rcsb pdb:5HBH|rcsb pdb:5HBJ|rcsb pdb:5HNB|rcsb pdb:5HVY|rcsb pdb:5I5Z|rcsb pdb:5ICP|rcsb pdb:5IDN|rcsb pdb:5IDP|rcsb pdb:5XQX|rcsb pdb:5XS2|rcsb pdb:6QTG|rcsb pdb:6QTJ|rcsb pdb:6R3S|rcsb pdb:6T41|rcsb pdb:6TPA|rcsb pdb:6Y0A|reactome:R-HSA-1989781|reactome:R-HSA-2122947|reactome:R-HSA-212436|reactome:R-HSA-2173796|reactome:R-HSA-2644606|reactome:R-HSA-2894862|reactome:R-HSA-381340|dip:DIP-32595N	ensembl:ENSG00000112237(gene)|ensembl:ENST00000520429(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0016538"(cyclin-dependent protein serine/threonine kinase regulator activity)|go:"GO:0016592"(mediator complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|interpro:IPR006671(Cyclin, N-terminal)|interpro:IPR013763(Cyclin-related)|interpro:IPR028367|interpro:IPR036915|interpro:IPR043198|mint:P24863|rcsb pdb:5XQX|rcsb pdb:5XS2|rcsb pdb:6QTG|rcsb pdb:6QTJ|rcsb pdb:6R3S|rcsb pdb:6T41|rcsb pdb:6TPA|rcsb pdb:6Y0A|reactome:R-HSA-1989781|reactome:R-HSA-2122947|reactome:R-HSA-212436|reactome:R-HSA-2173796|reactome:R-HSA-2644606|reactome:R-HSA-2894862|reactome:R-HSA-381340|rcsb pdb:3RGF|rcsb pdb:4CRL|rcsb pdb:4F6S|rcsb pdb:4F6U|rcsb pdb:4F6W|rcsb pdb:4F70|rcsb pdb:4F7J|rcsb pdb:4F7L|rcsb pdb:4F7N|rcsb pdb:4F7S|rcsb pdb:4G6L|rcsb pdb:5BNJ|rcsb pdb:5CEI|rcsb pdb:5FGK|rcsb pdb:5HBE|rcsb pdb:5HBH|rcsb pdb:5HBJ|rcsb pdb:5HNB|rcsb pdb:5HVY|rcsb pdb:5I5Z|rcsb pdb:5ICP|rcsb pdb:5IDN|rcsb pdb:5IDP|refseq:NP_005181.2|refseq:NP_001013417.1|dip:DIP-32920N	-	-	-	figure legend:Fig. 7|kinetics:Deletion of CDK8 residues 1-22 lowers the affinity to Kd = 300.71 +/-144.59 nanomolar.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:7.05x10^-9 ~0.85(molar)	2013/06/25	2014/10/16	rogid:f+78iyCfA9osCQ82uY6reu3JKzo9606	rogid:Gu327q98H8ggQoYCb4UnR2Mcsyg9606	intact-crc:59E9C138CFE9147D|rigid:j2upJguPtHaQkz9e1LS4qokdaAw	false	fluorescent dye label:?-?	fluorescent dye label:?-?	-	-	psi-mi:"MI:0867"(tag visualisation by fluorescence)	psi-mi:"MI:0867"(tag visualisation by fluorescence)