#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q9H2X6	uniprotkb:Q9H3D4	intact:EBI-348345|ensembl:ENSP00000385571|uniprotkb:Q75MR7|uniprotkb:Q8WWI4|uniprotkb:Q9H2Y1	intact:EBI-2337775|uniprotkb:O75080|uniprotkb:O75195|uniprotkb:O75922|uniprotkb:O76078|uniprotkb:Q6VEG2|uniprotkb:Q6VEG3|uniprotkb:Q6VEG4|uniprotkb:Q6VFJ1|uniprotkb:Q6VFJ2|uniprotkb:Q6VFJ3|uniprotkb:Q6VH20|uniprotkb:Q7LDI3|uniprotkb:Q7LDI4|uniprotkb:Q7LDI5|uniprotkb:Q96KR0|uniprotkb:Q9H3D2|uniprotkb:Q9H3D3|uniprotkb:Q9H3P8|uniprotkb:Q9NPH7|uniprotkb:Q9P1B4|uniprotkb:Q9P1B5|uniprotkb:Q9P1B6|uniprotkb:Q9P1B7|uniprotkb:Q9UBV9|uniprotkb:Q9UE10|uniprotkb:Q9UP26|uniprotkb:Q9UP27|uniprotkb:Q9UP28|uniprotkb:Q9UP74|ensembl:ENSP00000264731	psi-mi:hipk2_human(display_long)|uniprotkb:HIPK2(gene name)|psi-mi:HIPK2(display_short)	psi-mi:p63_human(display_long)|uniprotkb:TP63(gene name)|psi-mi:TP63(display_short)|uniprotkb:KET(gene name synonym)|uniprotkb:P63(gene name synonym)|uniprotkb:P73H(gene name synonym)|uniprotkb:P73L(gene name synonym)|uniprotkb:TP73L(gene name synonym)|uniprotkb:Transformation-related protein 63(gene name synonym)|uniprotkb:Tumor protein p73-like(gene name synonym)|uniprotkb:p51(gene name synonym)|uniprotkb:p40(gene name synonym)|uniprotkb:Keratinocyte transcription factor KET(gene name synonym)|uniprotkb:Chronic ulcerative stomatitis protein(gene name synonym)	psi-mi:"MI:0424"(protein kinase assay)	Lazzari et al. (2011)	imex:IM-18631|pubmed:21602882	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:1262"(I2D)	intact:EBI-6481127|imex:IM-18631-5	-	-	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0030578"(PML body organization)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0042771"(intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:0043388"(positive regulation of DNA binding)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046332"(SMAD binding)|go:"GO:0046790"(virion binding)|go:"GO:0048596"(embryonic camera-type eye morphogenesis)|go:"GO:0050882"(voluntary musculoskeletal movement)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060059"(embryonic retina morphogenesis in camera-type eye)|go:"GO:0060235"(lens induction in camera-type eye)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0061072"(iris morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:0097193"(intrinsic apoptotic signaling pathway)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1901796"(regulation of signal transduction by p53 class mediator)|go:"GO:2000059"(negative regulation of ubiquitin-dependent protein catabolic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|rcsb pdb:6P5S|rcsb pdb:7NCF|reactome:R-HSA-2032785|reactome:R-HSA-3899300|reactome:R-HSA-5578768|reactome:R-HSA-6804756|reactome:R-HSA-8939243|reactome:R-HSA-9022692|mint:Q9H2X6|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006978"(DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007224"(smoothened signaling pathway)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0010842"(retina layer formation)|go:"GO:0016604"(nuclear body)|go:"GO:0016605"(PML body)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|ensembl:ENSG00000064393(gene)|ensembl:ENST00000406875(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0019048"(modulation by virus of host process)|go:"GO:0001654"(eye development)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0030511"(positive regulation of transforming growth factor beta receptor signaling pathway)|refseq:NP_001106710.1|refseq:NP_073577.3|ensembl:ENSP00000385571|ensembl:ENST00000428878|ensembl:ENSP00000413724|dip:DIP-31716N	refseq:NP_001108450.1|refseq:NP_001108451.1|refseq:NP_001108452.1|refseq:NP_001108453.1|refseq:NP_001108454.1|refseq:NP_003713.3|ensembl:ENSP00000264731|ensembl:ENST00000320472|ensembl:ENSP00000317510|ensembl:ENST00000354600|ensembl:ENSP00000346614|ensembl:ENST00000392460|ensembl:ENSP00000376253|ensembl:ENST00000392461|ensembl:ENSP00000376254|ensembl:ENST00000392463|ensembl:ENSP00000376256|ensembl:ENST00000418709|ensembl:ENSP00000407144|ensembl:ENST00000437221|ensembl:ENSP00000392488|ensembl:ENST00000440651|ensembl:ENSP00000394337|ensembl:ENST00000449992|ensembl:ENSP00000387839|ensembl:ENST00000456148|ensembl:ENSP00000389485|refseq:NP_001316073.1|refseq:NP_001316074.1|refseq:NP_001316075.1|refseq:NP_001316077.1|refseq:XP_016862876.1|dip:DIP-29588N|interpro:IPR002117(p53 tumor antigen)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR010991(p53, tetramerisation)|interpro:IPR011615(p53, DNA-binding)|interpro:IPR012346(p53 and RUNT-type transcription factor, DNA-binding)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR032645|interpro:IPR036674|interpro:IPR037611|mint:Q9H3D4|rcsb pdb:1RG6|rcsb pdb:2NB1|rcsb pdb:2RMN|rcsb pdb:2Y9T|rcsb pdb:2Y9U|rcsb pdb:3QYM|rcsb pdb:3QYN|rcsb pdb:3US0|rcsb pdb:3US1|rcsb pdb:3US2|rcsb pdb:3ZY0|rcsb pdb:3ZY1|rcsb pdb:4A9Z|rcsb pdb:6FGN|rcsb pdb:6RU6|rcsb pdb:6RU7|rcsb pdb:6RU8|reactome:R-HSA-139915|reactome:R-HSA-5620971|reactome:R-HSA-5628897|reactome:R-HSA-6803204|reactome:R-HSA-6803205|reactome:R-HSA-6803207|reactome:R-HSA-6803211|reactome:R-HSA-6804759|interpro:IPR001660(Sterile alpha motif SAM)|ensembl:ENSG00000073282(gene)|ensembl:ENST00000264731(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001501"(skeletal system development)|go:"GO:0001736"(establishment of planar polarity)|go:"GO:0002039"(p53 binding)|go:"GO:0002064"(epithelial cell development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007499"(ectoderm and mesoderm interaction)|go:"GO:0007569"(cell aging)|go:"GO:0008283"(cell population proliferation)|go:"GO:0009954"(proximal/distal pattern formation)|go:"GO:0010259"(multicellular organism aging)|go:"GO:0010481"(epidermal cell division)|go:"GO:0010482"(regulation of epidermal cell division)|go:"GO:0010838"(positive regulation of keratinocyte proliferation)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0030425"(dendrite)|go:"GO:0030859"(polarized epithelial cell differentiation)|go:"GO:0031069"(hair follicle morphogenesis)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033147"(negative regulation of intracellular estrogen receptor signaling pathway)|go:"GO:0035115"(embryonic forelimb morphogenesis)|go:"GO:0035116"(embryonic hindlimb morphogenesis)|go:"GO:0036342"(post-anal tail morphogenesis)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0042771"(intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:0042802"(identical protein binding)|go:"GO:0043281"(regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043589"(skin morphogenesis)|go:"GO:0045617"(negative regulation of keratinocyte differentiation)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045747"(positive regulation of Notch signaling pathway)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048485"(sympathetic nervous system development)|go:"GO:0048807"(female genitalia morphogenesis)|go:"GO:0050699"(WW domain binding)|go:"GO:0051262"(protein tetramerization)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0060197"(cloacal septation)|go:"GO:0060513"(prostatic bud formation)|go:"GO:0060529"(squamous basal epithelial stem cell differentiation involved in prostate gland acinus development)|go:"GO:0061436"(establishment of skin barrier)|go:"GO:0097371"(MDM2/MDM4 family protein binding)|go:"GO:1902808"(positive regulation of cell cycle G1/S phase transition)|go:"GO:1904674"(positive regulation of somatic stem cell population maintenance)|go:"GO:1904888"(cranial skeletal system development)|go:"GO:2000271"(positive regulation of fibroblast apoptotic process)|go:"GO:2000381"(negative regulation of mesoderm development)|go:"GO:2000773"(negative regulation of cellular senescence)|go:"GO:2001235"(positive regulation of apoptotic signaling pathway)	-	-	-	figure legend:5a|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/01/18	2018/07/03	rogid:jCklf83jA3PA1CGAimi3q9E9CW49606	rogid:dwFwax9/monTAo8mJp1y7aGh+Cs9606	intact-crc:ABDEFBAA2939A228|rigid:Eo9zx/30ZKeQKaUZr6hprhmJzWc	false	glutathione s tranferase tag:?-?|mutation disrupting interaction rate:228-228	glutathione s tranferase tag:?-?	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:Q9H2X6	-	intact:EBI-348345|ensembl:ENSP00000385571|uniprotkb:Q75MR7|uniprotkb:Q8WWI4|uniprotkb:Q9H2Y1	-	psi-mi:hipk2_human(display_long)|uniprotkb:HIPK2(gene name)|psi-mi:HIPK2(display_short)	-	psi-mi:"MI:0424"(protein kinase assay)	Lazzari et al. (2011)	imex:IM-18631|pubmed:21602882	taxid:9606(human)|taxid:9606(Homo sapiens)	-	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:1262"(I2D)	intact:EBI-20597215|imex:IM-18631-1	-	-	psi-mi:"MI:0898"(putative self)	-	psi-mi:"MI:0898"(putative self)	-	psi-mi:"MI:0326"(protein)	-	go:"GO:0030578"(PML body organization)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0042771"(intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:0043388"(positive regulation of DNA binding)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046332"(SMAD binding)|go:"GO:0046790"(virion binding)|go:"GO:0048596"(embryonic camera-type eye morphogenesis)|go:"GO:0050882"(voluntary musculoskeletal movement)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060059"(embryonic retina morphogenesis in camera-type eye)|go:"GO:0060235"(lens induction in camera-type eye)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0061072"(iris morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:0097193"(intrinsic apoptotic signaling pathway)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1901796"(regulation of signal transduction by p53 class mediator)|go:"GO:2000059"(negative regulation of ubiquitin-dependent protein catabolic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|rcsb pdb:6P5S|rcsb pdb:7NCF|reactome:R-HSA-2032785|reactome:R-HSA-3899300|reactome:R-HSA-5578768|reactome:R-HSA-6804756|reactome:R-HSA-8939243|reactome:R-HSA-9022692|mint:Q9H2X6|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006978"(DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007224"(smoothened signaling pathway)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0010842"(retina layer formation)|go:"GO:0016604"(nuclear body)|go:"GO:0016605"(PML body)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|ensembl:ENSG00000064393(gene)|ensembl:ENST00000406875(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0019048"(modulation by virus of host process)|go:"GO:0001654"(eye development)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0030511"(positive regulation of transforming growth factor beta receptor signaling pathway)|refseq:NP_001106710.1|refseq:NP_073577.3|ensembl:ENSP00000385571|ensembl:ENST00000428878|ensembl:ENSP00000413724|dip:DIP-31716N	-	-	-	-	figure legend:5a|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/01/18	2018/07/03	rogid:jCklf83jA3PA1CGAimi3q9E9CW49606	-	-	false	glutathione s tranferase tag:?-?|mutation disrupting interaction rate:228-228	-	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	-
uniprotkb:Q9H3D4	uniprotkb:Q9H2X6	intact:EBI-2337775|uniprotkb:O75080|uniprotkb:O75195|uniprotkb:O75922|uniprotkb:O76078|uniprotkb:Q6VEG2|uniprotkb:Q6VEG3|uniprotkb:Q6VEG4|uniprotkb:Q6VFJ1|uniprotkb:Q6VFJ2|uniprotkb:Q6VFJ3|uniprotkb:Q6VH20|uniprotkb:Q7LDI3|uniprotkb:Q7LDI4|uniprotkb:Q7LDI5|uniprotkb:Q96KR0|uniprotkb:Q9H3D2|uniprotkb:Q9H3D3|uniprotkb:Q9H3P8|uniprotkb:Q9NPH7|uniprotkb:Q9P1B4|uniprotkb:Q9P1B5|uniprotkb:Q9P1B6|uniprotkb:Q9P1B7|uniprotkb:Q9UBV9|uniprotkb:Q9UE10|uniprotkb:Q9UP26|uniprotkb:Q9UP27|uniprotkb:Q9UP28|uniprotkb:Q9UP74|ensembl:ENSP00000264731	intact:EBI-348345|ensembl:ENSP00000385571|uniprotkb:Q75MR7|uniprotkb:Q8WWI4|uniprotkb:Q9H2Y1	psi-mi:p63_human(display_long)|uniprotkb:TP63(gene name)|psi-mi:TP63(display_short)|uniprotkb:KET(gene name synonym)|uniprotkb:P63(gene name synonym)|uniprotkb:P73H(gene name synonym)|uniprotkb:P73L(gene name synonym)|uniprotkb:TP73L(gene name synonym)|uniprotkb:Transformation-related protein 63(gene name synonym)|uniprotkb:Tumor protein p73-like(gene name synonym)|uniprotkb:p51(gene name synonym)|uniprotkb:p40(gene name synonym)|uniprotkb:Keratinocyte transcription factor KET(gene name synonym)|uniprotkb:Chronic ulcerative stomatitis protein(gene name synonym)	psi-mi:hipk2_human(display_long)|uniprotkb:HIPK2(gene name)|psi-mi:HIPK2(display_short)	psi-mi:"MI:0424"(protein kinase assay)	Lazzari et al. (2011)	imex:IM-18631|pubmed:21602882	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:1262"(I2D)	intact:EBI-20597223|imex:IM-18631-3	-	-	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001108450.1|refseq:NP_001108451.1|refseq:NP_001108452.1|refseq:NP_001108453.1|refseq:NP_001108454.1|refseq:NP_003713.3|ensembl:ENSP00000264731|ensembl:ENST00000320472|ensembl:ENSP00000317510|ensembl:ENST00000354600|ensembl:ENSP00000346614|ensembl:ENST00000392460|ensembl:ENSP00000376253|ensembl:ENST00000392461|ensembl:ENSP00000376254|ensembl:ENST00000392463|ensembl:ENSP00000376256|ensembl:ENST00000418709|ensembl:ENSP00000407144|ensembl:ENST00000437221|ensembl:ENSP00000392488|ensembl:ENST00000440651|ensembl:ENSP00000394337|ensembl:ENST00000449992|ensembl:ENSP00000387839|ensembl:ENST00000456148|ensembl:ENSP00000389485|refseq:NP_001316073.1|refseq:NP_001316074.1|refseq:NP_001316075.1|refseq:NP_001316077.1|refseq:XP_016862876.1|dip:DIP-29588N|interpro:IPR002117(p53 tumor antigen)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR010991(p53, tetramerisation)|interpro:IPR011615(p53, DNA-binding)|interpro:IPR012346(p53 and RUNT-type transcription factor, DNA-binding)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR032645|interpro:IPR036674|interpro:IPR037611|mint:Q9H3D4|rcsb pdb:1RG6|rcsb pdb:2NB1|rcsb pdb:2RMN|rcsb pdb:2Y9T|rcsb pdb:2Y9U|rcsb pdb:3QYM|rcsb pdb:3QYN|rcsb pdb:3US0|rcsb pdb:3US1|rcsb pdb:3US2|rcsb pdb:3ZY0|rcsb pdb:3ZY1|rcsb pdb:4A9Z|rcsb pdb:6FGN|rcsb pdb:6RU6|rcsb pdb:6RU7|rcsb pdb:6RU8|reactome:R-HSA-139915|reactome:R-HSA-5620971|reactome:R-HSA-5628897|reactome:R-HSA-6803204|reactome:R-HSA-6803205|reactome:R-HSA-6803207|reactome:R-HSA-6803211|reactome:R-HSA-6804759|interpro:IPR001660(Sterile alpha motif SAM)|ensembl:ENSG00000073282(gene)|ensembl:ENST00000264731(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001501"(skeletal system development)|go:"GO:0001736"(establishment of planar polarity)|go:"GO:0002039"(p53 binding)|go:"GO:0002064"(epithelial cell development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007499"(ectoderm and mesoderm interaction)|go:"GO:0007569"(cell aging)|go:"GO:0008283"(cell population proliferation)|go:"GO:0009954"(proximal/distal pattern formation)|go:"GO:0010259"(multicellular organism aging)|go:"GO:0010481"(epidermal cell division)|go:"GO:0010482"(regulation of epidermal cell division)|go:"GO:0010838"(positive regulation of keratinocyte proliferation)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0030425"(dendrite)|go:"GO:0030859"(polarized epithelial cell differentiation)|go:"GO:0031069"(hair follicle morphogenesis)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033147"(negative regulation of intracellular estrogen receptor signaling pathway)|go:"GO:0035115"(embryonic forelimb morphogenesis)|go:"GO:0035116"(embryonic hindlimb morphogenesis)|go:"GO:0036342"(post-anal tail morphogenesis)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0042771"(intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:0042802"(identical protein binding)|go:"GO:0043281"(regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043589"(skin morphogenesis)|go:"GO:0045617"(negative regulation of keratinocyte differentiation)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045747"(positive regulation of Notch signaling pathway)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048485"(sympathetic nervous system development)|go:"GO:0048807"(female genitalia morphogenesis)|go:"GO:0050699"(WW domain binding)|go:"GO:0051262"(protein tetramerization)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0060197"(cloacal septation)|go:"GO:0060513"(prostatic bud formation)|go:"GO:0060529"(squamous basal epithelial stem cell differentiation involved in prostate gland acinus development)|go:"GO:0061436"(establishment of skin barrier)|go:"GO:0097371"(MDM2/MDM4 family protein binding)|go:"GO:1902808"(positive regulation of cell cycle G1/S phase transition)|go:"GO:1904674"(positive regulation of somatic stem cell population maintenance)|go:"GO:1904888"(cranial skeletal system development)|go:"GO:2000271"(positive regulation of fibroblast apoptotic process)|go:"GO:2000381"(negative regulation of mesoderm development)|go:"GO:2000773"(negative regulation of cellular senescence)|go:"GO:2001235"(positive regulation of apoptotic signaling pathway)	go:"GO:0030578"(PML body organization)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0042771"(intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:0043388"(positive regulation of DNA binding)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046332"(SMAD binding)|go:"GO:0046790"(virion binding)|go:"GO:0048596"(embryonic camera-type eye morphogenesis)|go:"GO:0050882"(voluntary musculoskeletal movement)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060059"(embryonic retina morphogenesis in camera-type eye)|go:"GO:0060235"(lens induction in camera-type eye)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0061072"(iris morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:0097193"(intrinsic apoptotic signaling pathway)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1901796"(regulation of signal transduction by p53 class mediator)|go:"GO:2000059"(negative regulation of ubiquitin-dependent protein catabolic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|rcsb pdb:6P5S|rcsb pdb:7NCF|reactome:R-HSA-2032785|reactome:R-HSA-3899300|reactome:R-HSA-5578768|reactome:R-HSA-6804756|reactome:R-HSA-8939243|reactome:R-HSA-9022692|mint:Q9H2X6|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006978"(DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007224"(smoothened signaling pathway)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0010842"(retina layer formation)|go:"GO:0016604"(nuclear body)|go:"GO:0016605"(PML body)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|ensembl:ENSG00000064393(gene)|ensembl:ENST00000406875(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0019048"(modulation by virus of host process)|go:"GO:0001654"(eye development)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0030511"(positive regulation of transforming growth factor beta receptor signaling pathway)|refseq:NP_001106710.1|refseq:NP_073577.3|ensembl:ENSP00000385571|ensembl:ENST00000428878|ensembl:ENSP00000413724|dip:DIP-31716N	-	-	-	figure legend:5d|dataset:Cancer - Interactions investigated in the context of cancer|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2013/01/18	2018/07/03	rogid:dwFwax9/monTAo8mJp1y7aGh+Cs9606	rogid:jCklf83jA3PA1CGAimi3q9E9CW49606	rigid:Eo9zx/30ZKeQKaUZr6hprhmJzWc	false	glutathione s tranferase tag:?-?|mutation disrupting interaction strength:491-491	his tag:n-n|sufficient binding region:165-564	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)