#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q9QUQ5	uniprotkb:P55284	intact:EBI-7385752|ensembl:ENSMUSP00000029311|uniprotkb:Q9QZC0|intact:MINT-144626|uniprotkb:Q62350|uniprotkb:Q9QUQ9	intact:EBI-7087433|ensembl:ENSMUSP00000034339|uniprotkb:O35542|intact:MINT-247286	psi-mi:trpc4_mouse(display_long)|uniprotkb:Trpc4(gene name)|psi-mi:Trpc4(display_short)|uniprotkb:Trrp4(gene name synonym)|uniprotkb:Receptor-activated cation channel TRP4(gene name synonym)|uniprotkb:Capacitative calcium entry channel Trp4(gene name synonym)	psi-mi:cadh5_mouse(display_long)|uniprotkb:Cdh5(gene name)|psi-mi:Cdh5(display_short)|uniprotkb:Vascular endothelial cadherin(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Graziani et al. (2010)	pubmed:19996314|imex:IM-22109	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-8871600|imex:IM-22109-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_006501359.1|ensembl:ENSMUSG00000027748(gene)|ensembl:ENSMUST00000029311(transcript)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006828"(manganese ion transport)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0009986"(cell surface)|go:"GO:0014051"(gamma-aminobutyric acid secretion)|go:"GO:0015279"(store-operated calcium channel activity)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034703"(cation channel complex)|go:"GO:0034704"(calcium channel complex)|go:"GO:0045121"(membrane raft)|go:"GO:0045296"(cadherin binding)|go:"GO:0048709"(oligodendrocyte differentiation)|go:"GO:0051480"(regulation of cytosolic calcium ion concentration)|go:"GO:0051924"(regulation of calcium ion transport)|go:"GO:0070588"(calcium ion transmembrane transport)|go:"GO:0070679"(inositol 1,4,5 trisphosphate binding)|interpro:IPR002110(Ankyrin)|interpro:IPR002153(Transient receptor potential protein)|interpro:IPR005460(Transient receptor potential channel 4)|interpro:IPR005821(Ion transport)|interpro:IPR013555(Transient receptor potential II)|interpro:IPR036770|rcsb pdb:5Z96|rcsb pdb:6JZO|rcsb pdb:7CQP|reactome:R-MMU-3295583|go:"GO:0070509"(calcium ion import)|refseq:NP_058680.1|refseq:NP_001240611.1|dip:DIP-40848N	refseq:XP_006530693.1|ensembl:ENSMUSG00000031871(gene)|ensembl:ENSMUST00000034339(transcript)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001944"(vasculature development)|go:"GO:0001955"(blood vessel maturation)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005912"(adherens junction)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0007043"(cell-cell junction assembly)|go:"GO:0007156"(homophilic cell adhesion via plasma membrane adhesion molecules)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016339"(calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0016342"(catenin complex)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030054"(cell junction)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030513"(positive regulation of BMP signaling pathway)|go:"GO:0031115"(negative regulation of microtubule polymerization)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0031965"(nuclear membrane)|go:"GO:0034332"(adherens junction organization)|go:"GO:0035307"(positive regulation of protein dephosphorylation)|go:"GO:0043114"(regulation of vascular permeability)|go:"GO:0043184"(vascular endothelial growth factor receptor 2 binding)|go:"GO:0043534"(blood vessel endothelial cell migration)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044331"(cell-cell adhesion mediated by cadherin)|go:"GO:0045296"(cadherin binding)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0070051"(fibrinogen binding)|go:"GO:0070700"(BMP receptor binding)|go:"GO:0070830"(bicellular tight junction assembly)|go:"GO:0071944"(cell periphery)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098742"(cell-cell adhesion via plasma-membrane adhesion molecules)|go:"GO:1902396"(protein localization to bicellular tight junction)|go:"GO:1903142"(positive regulation of establishment of endothelial barrier)|go:"GO:1990782"(protein tyrosine kinase binding)|go:"GO:2000114"(regulation of establishment of cell polarity)|go:"GO:2000352"(negative regulation of endothelial cell apoptotic process)|interpro:IPR000233(Cadherin cytoplasmic region)|interpro:IPR002126(Cadherin)|interpro:IPR015919(Cadherin-like)|interpro:IPR020894|interpro:IPR027397|interpro:IPR030052|interpro:IPR039808|mint:P55284|rcsb pdb:2KOH|reactome:R-MMU-418990|reactome:R-MMU-5218920|refseq:NP_033998.2	-	comment:mint|function:"Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Has also been shown to be calcium-selective (By similarity). May also be activated by intracellular calcium store depletion. TRPC4 deficient mice lack a store-operated calcium entry in endothelial cells"	comment:mint|function:Cadherins are calcium dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. This cadherin may play a important role in endothelial cell biology through control of the cohesion and organization of the intercellular junctions	figure legend:Fig. 4a|antagonist:"EGF (10 ng/ml) of unknown species acts as an antagonist in both subconfluent and confluent cultures."|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hmec-1)|taxid:9606(Human HMEC-1 immortalized  microvascular endothelial cell line)	-	2013/11/22	2014/10/16	rogid:anLoCpTwauGHInK3SS326aDsyiw10090	rogid:OU7DgfEEwHyVcX7XGNJnQQw4sTk10090	intact-crc:2C26CFD172C39117|rigid:edlRvKDsATitdRpad1RVkWisePQ	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9QUQ5	uniprotkb:P55284	intact:EBI-7385752|ensembl:ENSMUSP00000029311|uniprotkb:Q9QZC0|intact:MINT-144626|uniprotkb:Q62350|uniprotkb:Q9QUQ9	intact:EBI-7087433|ensembl:ENSMUSP00000034339|uniprotkb:O35542|intact:MINT-247286	psi-mi:trpc4_mouse(display_long)|uniprotkb:Trpc4(gene name)|psi-mi:Trpc4(display_short)|uniprotkb:Trrp4(gene name synonym)|uniprotkb:Receptor-activated cation channel TRP4(gene name synonym)|uniprotkb:Capacitative calcium entry channel Trp4(gene name synonym)	psi-mi:cadh5_mouse(display_long)|uniprotkb:Cdh5(gene name)|psi-mi:Cdh5(display_short)|uniprotkb:Vascular endothelial cadherin(gene name synonym)	psi-mi:"MI:0055"(fluorescent resonance energy transfer)	Graziani et al. (2010)	pubmed:19996314|imex:IM-22109	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:2364"(proximity)	psi-mi:"MI:1332"(bhf-ucl)	intact:EBI-8871957|imex:IM-22109-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_006501359.1|ensembl:ENSMUSG00000027748(gene)|ensembl:ENSMUST00000029311(transcript)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006828"(manganese ion transport)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0009986"(cell surface)|go:"GO:0014051"(gamma-aminobutyric acid secretion)|go:"GO:0015279"(store-operated calcium channel activity)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034703"(cation channel complex)|go:"GO:0034704"(calcium channel complex)|go:"GO:0045121"(membrane raft)|go:"GO:0045296"(cadherin binding)|go:"GO:0048709"(oligodendrocyte differentiation)|go:"GO:0051480"(regulation of cytosolic calcium ion concentration)|go:"GO:0051924"(regulation of calcium ion transport)|go:"GO:0070588"(calcium ion transmembrane transport)|go:"GO:0070679"(inositol 1,4,5 trisphosphate binding)|interpro:IPR002110(Ankyrin)|interpro:IPR002153(Transient receptor potential protein)|interpro:IPR005460(Transient receptor potential channel 4)|interpro:IPR005821(Ion transport)|interpro:IPR013555(Transient receptor potential II)|interpro:IPR036770|rcsb pdb:5Z96|rcsb pdb:6JZO|rcsb pdb:7CQP|reactome:R-MMU-3295583|go:"GO:0070509"(calcium ion import)|refseq:NP_058680.1|refseq:NP_001240611.1|dip:DIP-40848N	refseq:XP_006530693.1|ensembl:ENSMUSG00000031871(gene)|ensembl:ENSMUST00000034339(transcript)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001944"(vasculature development)|go:"GO:0001955"(blood vessel maturation)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005912"(adherens junction)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0007043"(cell-cell junction assembly)|go:"GO:0007156"(homophilic cell adhesion via plasma membrane adhesion molecules)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016339"(calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0016342"(catenin complex)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030054"(cell junction)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030513"(positive regulation of BMP signaling pathway)|go:"GO:0031115"(negative regulation of microtubule polymerization)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0031965"(nuclear membrane)|go:"GO:0034332"(adherens junction organization)|go:"GO:0035307"(positive regulation of protein dephosphorylation)|go:"GO:0043114"(regulation of vascular permeability)|go:"GO:0043184"(vascular endothelial growth factor receptor 2 binding)|go:"GO:0043534"(blood vessel endothelial cell migration)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044331"(cell-cell adhesion mediated by cadherin)|go:"GO:0045296"(cadherin binding)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0070051"(fibrinogen binding)|go:"GO:0070700"(BMP receptor binding)|go:"GO:0070830"(bicellular tight junction assembly)|go:"GO:0071944"(cell periphery)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098742"(cell-cell adhesion via plasma-membrane adhesion molecules)|go:"GO:1902396"(protein localization to bicellular tight junction)|go:"GO:1903142"(positive regulation of establishment of endothelial barrier)|go:"GO:1990782"(protein tyrosine kinase binding)|go:"GO:2000114"(regulation of establishment of cell polarity)|go:"GO:2000352"(negative regulation of endothelial cell apoptotic process)|interpro:IPR000233(Cadherin cytoplasmic region)|interpro:IPR002126(Cadherin)|interpro:IPR015919(Cadherin-like)|interpro:IPR020894|interpro:IPR027397|interpro:IPR030052|interpro:IPR039808|mint:P55284|rcsb pdb:2KOH|reactome:R-MMU-418990|reactome:R-MMU-5218920|refseq:NP_033998.2	go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)	comment:mint|function:"Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Has also been shown to be calcium-selective (By similarity). May also be activated by intracellular calcium store depletion. TRPC4 deficient mice lack a store-operated calcium entry in endothelial cells"	comment:mint|function:Cadherins are calcium dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. This cadherin may play a important role in endothelial cell biology through control of the cohesion and organization of the intercellular junctions	figure legend:Fig. 6b|dataset:Cardiac - Interactions involving cardiac related proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2013/11/22	2014/10/16	rogid:anLoCpTwauGHInK3SS326aDsyiw10090	rogid:OU7DgfEEwHyVcX7XGNJnQQw4sTk10090	intact-crc:93ECD1331659D1BF|rigid:edlRvKDsATitdRpad1RVkWisePQ	false	cyan fluorescent protein tag:n-n	enhanced yellow fluorescent protein tag:c-c	-	-	psi-mi:"MI:0867"(tag visualisation by fluorescence)	psi-mi:"MI:0867"(tag visualisation by fluorescence)